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Aliases for LRIG3 Gene

Aliases for LRIG3 Gene

  • Leucine Rich Repeats And Immunoglobulin Like Domains 3 2 3 5
  • LIG-3 3 4
  • LIG3 3 4
  • Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 3 3

External Ids for LRIG3 Gene

Previous GeneCards Identifiers for LRIG3 Gene

  • GC12M057553
  • GC12M057554
  • GC12M059265
  • GC12M056314

Summaries for LRIG3 Gene

GeneCards Summary for LRIG3 Gene

LRIG3 (Leucine Rich Repeats And Immunoglobulin Like Domains 3) is a Protein Coding gene. An important paralog of this gene is LRIG2.

UniProtKB/Swiss-Prot for LRIG3 Gene

  • May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIG3 Gene

Genomics for LRIG3 Gene

Regulatory Elements for LRIG3 Gene

Enhancers for LRIG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F058949 0.7 ENCODE 17.8 -30.1 -30085 1.7 SCRT1 YY2 SCRT2 ZIC2 LRIG3 GC12P058951 ENSG00000257443
GH12F058887 0.5 ENCODE 17.1 +32.3 32255 1.5 ZNF316 SCRT2 FOXP2 RAD21 MAFK LRIG3 LOC101927653
GH12F058527 1.7 FANTOM5 Ensembl ENCODE 15 +390.6 390618 3.9 MLX FEZF1 ZNF2 RAD21 ZNF366 FOS ZNF263 ZNF680 OVOL3 TSHZ1 LRIG3 CTDSP2 LOC100506869 GC12M058472
GH12F058906 0.7 FANTOM5 ENCODE 8.1 +13.0 12994 1.2 PRDM10 ZBTB33 LRIG3 LOC101927653
GH12F058913 0.9 FANTOM5 Ensembl ENCODE 7.1 +1.6 1632 9.9 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 NFYC LRIG3 ENSG00000257443 LOC101927653
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRIG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRIG3 Gene

Chromosome:
12
Start:
58,872,149 bp from pter
End:
58,920,538 bp from pter
Size:
48,390 bases
Orientation:
Minus strand

Genomic View for LRIG3 Gene

Genes around LRIG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRIG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRIG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRIG3 Gene

Proteins for LRIG3 Gene

  • Protein details for LRIG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXM1-LRIG3_HUMAN
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 3
    Protein Accession:
    Q6UXM1
    Secondary Accessions:
    • Q6UXL7
    • Q8NC72

    Protein attributes for LRIG3 Gene

    Size:
    1119 amino acids
    Molecular mass:
    123434 Da
    Quaternary structure:
    • Interacts with EGFR, ERBB2 and ERBB4 (in vitro).
    SequenceCaution:
    • Sequence=BAC11295.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRIG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRIG3 Gene

Post-translational modifications for LRIG3 Gene

  • Glycosylation at Asn 122, Asn 156, Asn 274, Asn 442, Asn 469, Asn 515, Asn 688, Asn 729, Asn 905, Asn 987, Asn 999, and Asn 1016
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRIG3 Gene

Domains & Families for LRIG3 Gene

Gene Families for LRIG3 Gene

Suggested Antigen Peptide Sequences for LRIG3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UXM1

UniProtKB/Swiss-Prot:

LRIG3_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 15 LRR (leucine-rich) repeats.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRIG3: view

Function for LRIG3 Gene

Molecular function for LRIG3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).
genes like me logo Genes that share phenotypes with LRIG3: view

Animal Models for LRIG3 Gene

MGI Knock Outs for LRIG3:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRIG3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRIG3 Gene

Localization for LRIG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIG3 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRIG3 Gene COMPARTMENTS Subcellular localization image for LRIG3 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LRIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with LRIG3: view

Pathways & Interactions for LRIG3 Gene

SuperPathways for LRIG3 Gene

No Data Available

SIGNOR curated interactions for LRIG3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LRIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0032474 otolith morphogenesis IEA --
genes like me logo Genes that share ontologies with LRIG3: view

No data available for Pathways by source for LRIG3 Gene

Transcripts for LRIG3 Gene

Unigene Clusters for LRIG3 Gene

Leucine-rich repeats and immunoglobulin-like domains 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRIG3 Gene

No ASD Table

Relevant External Links for LRIG3 Gene

GeneLoc Exon Structure for
LRIG3
ECgene alternative splicing isoforms for
LRIG3

Expression for LRIG3 Gene

mRNA expression in normal human tissues for LRIG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRIG3 Gene

This gene is overexpressed in Platelet (53.8) and Heart (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRIG3 Gene



Protein tissue co-expression partners for LRIG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRIG3 Gene:

LRIG3

SOURCE GeneReport for Unigene cluster for LRIG3 Gene:

Hs.253736

mRNA Expression by UniProt/SwissProt for LRIG3 Gene:

Q6UXM1-LRIG3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with LRIG3: view

Primer Products

No data available for mRNA differential expression in normal tissues for LRIG3 Gene

Orthologs for LRIG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRIG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRIG3 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia LRIG3 34 35
  • 90.93 (n)
cow
(Bos Taurus)
Mammalia LRIG3 34 35
  • 89.19 (n)
rat
(Rattus norvegicus)
Mammalia Lrig3 34
  • 83.93 (n)
mouse
(Mus musculus)
Mammalia Lrig3 34 16 35
  • 83.65 (n)
oppossum
(Monodelphis domestica)
Mammalia LRIG3 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRIG3 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRIG3 34 35
  • 76.06 (n)
lizard
(Anolis carolinensis)
Reptilia LRIG3 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrig3 34
  • 69.98 (n)
zebrafish
(Danio rerio)
Actinopterygii lrig3 34
  • 64.84 (n)
LRIG3 35
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lbk 34 35
  • 47.47 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009688 34
  • 27.09 (n)
worm
(Caenorhabditis elegans)
Secernentea sma-10 34 35
  • 44.38 (n)
Species where no ortholog for LRIG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRIG3 Gene

ENSEMBL:
Gene Tree for LRIG3 (if available)
TreeFam:
Gene Tree for LRIG3 (if available)

Paralogs for LRIG3 Gene

Variants for LRIG3 Gene

Sequence variations from dbSNP and Humsavar for LRIG3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1020031 -- 58,901,672(+) GGAGA(A/G)GGGAA intron-variant
rs10506358 -- 58,907,789(-) TGTGC(A/G)TTAGA intron-variant
rs10506359 -- 58,881,938(-) CATAG(G/T)TTTTT intron-variant
rs10506360 -- 58,873,657(-) ACCCG(C/T)AGTCG intron-variant
rs10597177 -- 58,897,437(+) AACAC(-/AT)GTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRIG3 Gene

Variant ID Type Subtype PubMed ID
esv2759902 CNV gain 17122850
nsv733 CNV insertion 18451855

Variation tolerance for LRIG3 Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRIG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRIG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRIG3 Gene

Disorders for LRIG3 Gene

Relevant External Links for LRIG3

Genetic Association Database (GAD)
LRIG3
Human Genome Epidemiology (HuGE) Navigator
LRIG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRIG3

No disorders were found for LRIG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRIG3 Gene

Publications for LRIG3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PMID: 20446891) Andersson U. … Melin B. (Acta Oncol 2010) 3 46 64
  3. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 20445134) Smith N.L. … Vasan R.S. (Circ Cardiovasc Genet 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. (PMID: 15203213) Guo D. … Hedman H. (Genomics 2004) 3 4 64

Products for LRIG3 Gene

Sources for LRIG3 Gene

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