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Aliases for LRIG3 Gene

Aliases for LRIG3 Gene

  • Leucine-Rich Repeats And Immunoglobulin Like Domains 3 2 3
  • Leucine-Rich Repeats And Immunoglobulin-Like Domains 3 2 3 5
  • LIG-3 3 4
  • LIG3 3 4

External Ids for LRIG3 Gene

Previous GeneCards Identifiers for LRIG3 Gene

  • GC12M057553
  • GC12M057554
  • GC12M059265
  • GC12M056314

Summaries for LRIG3 Gene

GeneCards Summary for LRIG3 Gene

LRIG3 (Leucine-Rich Repeats And Immunoglobulin Like Domains 3) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is LRRTM2.

UniProtKB/Swiss-Prot for LRIG3 Gene

  • May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIG3 Gene

Genomics for LRIG3 Gene

Regulatory Elements for LRIG3 Gene

Genomic Location for LRIG3 Gene

Chromosome:
12
Start:
58,872,149 bp from pter
End:
58,920,538 bp from pter
Size:
48,390 bases
Orientation:
Minus strand

Genomic View for LRIG3 Gene

Genes around LRIG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRIG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRIG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRIG3 Gene

Proteins for LRIG3 Gene

  • Protein details for LRIG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXM1-LRIG3_HUMAN
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 3
    Protein Accession:
    Q6UXM1
    Secondary Accessions:
    • Q6UXL7
    • Q8NC72

    Protein attributes for LRIG3 Gene

    Size:
    1119 amino acids
    Molecular mass:
    123434 Da
    Quaternary structure:
    • Interacts with EGFR, ERBB2 and ERBB4 (in vitro).
    SequenceCaution:
    • Sequence=BAC11295.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRIG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRIG3 Gene

Proteomics data for LRIG3 Gene at MOPED

Post-translational modifications for LRIG3 Gene

  • Glycosylation at Asn 122, Asn 156, Asn 274, Asn 442, Asn 469, Asn 515, Asn 688, Asn 729, Asn 905, Asn 987, Asn 999, and Asn 1016
  • Modification sites at PhosphoSitePlus

Other Protein References for LRIG3 Gene

Antibody Products

No data available for DME Specific Peptides for LRIG3 Gene

Domains & Families for LRIG3 Gene

Gene Families for LRIG3 Gene

Suggested Antigen Peptide Sequences for LRIG3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UXM1

UniProtKB/Swiss-Prot:

LRIG3_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 15 LRR (leucine-rich) repeats.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRIG3: view

Function for LRIG3 Gene

Molecular function for LRIG3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).
genes like me logo Genes that share phenotypes with LRIG3: view

Animal Models for LRIG3 Gene

MGI Knock Outs for LRIG3:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRIG3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRIG3 Gene

Localization for LRIG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIG3 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRIG3 Gene COMPARTMENTS Subcellular localization image for LRIG3 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LRIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRIG3: view

Pathways & Interactions for LRIG3 Gene

genes like me logo Genes that share pathways with LRIG3: view

Interacting Proteins for LRIG3 Gene

SIGNOR curated interactions for LRIG3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LRIG3 Gene

None

Drugs & Compounds for LRIG3 Gene

No Compound Related Data Available

Transcripts for LRIG3 Gene

Unigene Clusters for LRIG3 Gene

Leucine-rich repeats and immunoglobulin-like domains 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRIG3 Gene

No ASD Table

Relevant External Links for LRIG3 Gene

GeneLoc Exon Structure for
LRIG3
ECgene alternative splicing isoforms for
LRIG3

Expression for LRIG3 Gene

mRNA expression in normal human tissues for LRIG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRIG3 Gene

This gene is overexpressed in Platelet (53.8) and Heart (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRIG3 Gene



SOURCE GeneReport for Unigene cluster for LRIG3 Gene Hs.253736

mRNA Expression by UniProt/SwissProt for LRIG3 Gene

Q6UXM1-LRIG3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with LRIG3: view

Protein tissue co-expression partners for LRIG3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LRIG3 Gene

Orthologs for LRIG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRIG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRIG3 36
  • 99 (a)
OneToOne
LRIG3 35
  • 99.29 (n)
  • 99.46 (a)
cow
(Bos Taurus)
Mammalia LRIG3 35
  • 89.19 (n)
  • 91.15 (a)
LRIG3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRIG3 36
  • 94 (a)
OneToOne
LRIG3 35
  • 90.93 (n)
  • 94.42 (a)
mouse
(Mus musculus)
Mammalia Lrig3 16
Lrig3 36
  • 86 (a)
OneToOne
Lrig3 35
  • 83.65 (n)
  • 86.12 (a)
oppossum
(Monodelphis domestica)
Mammalia LRIG3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRIG3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrig3 35
  • 83.93 (n)
  • 87.1 (a)
chicken
(Gallus gallus)
Aves LRIG3 35
  • 76.06 (n)
  • 79.05 (a)
LRIG3 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRIG3 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrig3 35
  • 69.98 (n)
  • 71.17 (a)
zebrafish
(Danio rerio)
Actinopterygii LRIG3 36
  • 60 (a)
OneToOne
lrig3 35
  • 64.84 (n)
  • 68.13 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009688 35
  • 27.09 (n)
  • 9.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta lbk 36
  • 26 (a)
OneToMany
lbk 35
  • 47.47 (n)
  • 38.48 (a)
worm
(Caenorhabditis elegans)
Secernentea sma-10 35
  • 44.38 (n)
  • 33.56 (a)
sma-10 36
  • 29 (a)
OneToMany
Species with no ortholog for LRIG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRIG3 Gene

ENSEMBL:
Gene Tree for LRIG3 (if available)
TreeFam:
Gene Tree for LRIG3 (if available)

Paralogs for LRIG3 Gene

genes like me logo Genes that share paralogs with LRIG3: view

Variants for LRIG3 Gene

Sequence variations from dbSNP and Humsavar for LRIG3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2167030 -- 58,901,891(-) CTGAC(C/T)GCCCT intron-variant
rs2118085 -- 58,907,277(+) GCATT(C/T)TGAAG intron-variant
rs2291799 -- 58,913,665(-) ATTTT(A/G)GTATC intron-variant
rs2291800 -- 58,913,518(-) CAGTG(G/T)AAATC intron-variant
rs2293660 -- 58,878,591(+) CCCCT(C/G)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRIG3 Gene

Variant ID Type Subtype PubMed ID
dgv514e1 CNV Complex 17122850
nsv733 CNV Insertion 18451855

Variation tolerance for LRIG3 Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRIG3 Gene

HapMap Linkage Disequilibrium report
LRIG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRIG3 Gene

Disorders for LRIG3 Gene

Relevant External Links for LRIG3

Genetic Association Database (GAD)
LRIG3
Human Genome Epidemiology (HuGE) Navigator
LRIG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRIG3

No disorders were found for LRIG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRIG3 Gene

Publications for LRIG3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Expression and significance of LRIG3 in human cervical squamous cell carcinoma. (PMID: 26390694) Guo L. … Zhang R. (Eur. J. Gynaecol. Oncol. 2015) 3
  4. Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome. (PMID: 24998916) LindstrAPm A.K. … Hellberg D. (Eur J Histochem 2014) 3
  5. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 3

Products for LRIG3 Gene

Sources for LRIG3 Gene

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