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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRIG3 Gene

protein-coding   GIFtS: 48
GCID: GC12M059265

leucine-rich repeats and immunoglobulin-like domains 3
 Explore 7 diseases affiliated with
LRIG3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LRIG3    

Aliases
for LRIG3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Leucine-Rich Repeats And Immunoglobulin-Like Domains 31 2     KIAA30161
LIG32 3 5     Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 32
LIG-32 3     LIRG35
FLJ904401     

External Ids:    HGNC: 309911   Entrez Gene: 1212272   Ensembl: ENSG000001392637   OMIM: 6088705   UniProtKB: Q6UXM13   

Export aliases for LRIG3 gene to outside databases

Previous GC identifers: GC12M057553 GC12M057554 GC12M056314


Summaries
for LRIG3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the
otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by
restricting the expression of NTN1 (By similarity)

summary for LRIG3:
Ligases catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or
a similar triphosphate. They belong to the E.C. 6 class, which also includes synthases and carboxylases. DNA
ligases play an integral role in DNA repair and replication: they catalyze the formation of phosphodiester
bonds, using ATP as a co-factor. These enzymes are divided into three classes: DNA ligase I, III and IV. DNA
ligase I links Okazaki fragments to form a continuous strand of DNA. DNA ligase III is involved in base
excision repair. Finally, DNA ligase IV is involved in the repair of DNA double-strand breaks by
non-homologous end joining (NHEJ).




Genomic Views
for LRIG3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRIG3 gene promoter:
         MEF-2A   FOXD3   aMEF-2   Nkx2-5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LRIG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRIG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRIG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q13.2

LRIG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRIG3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M059265:  view genomic region     (about GC identifiers)

Start:
 59,265,931 bp from pter      End:
 59,314,303 bp from pter
Size:
 48,373 bases      Orientation:
 minus strand

Proteins
for LRIG3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1 (See protein sequence)
Recommended Name: Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor  
Size: 1119 amino acids; 123434 Da
Subunit: Interacts with EGFR, ERBB2 and ERBB4 (in vitro) (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle membrane;
Single-pass type I membrane protein (By similarity). Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4
(By similarity)
Sequence caution: Sequence=BAC11295.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6UXL7 Q8NC72
Alternative splicing: 2 isoforms:  Q6UXM1-1   Q6UXM1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRIG3: NX_Q6UXM1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UXM1

    • LRIG3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129523.1  NP_700356.2  

    ENSEMBL proteins: 
     ENSP00000368436   ENSP00000326759   ENSP00000413143   ENSP00000449169   ENSP00000449109  

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    Novus Biologicals LRIG3 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LRIG3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--


    LRIG3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for LRIG3

    Protein Domains /
    Families
    for LRIG3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LRIG3 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR003598 Ig_sub2
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q6UXM1

    ProtoNet protein and cluster: Q6UXM1

    4 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 15 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Function
    for LRIG3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
    Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the
    otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by
    restricting the expression of NTN1 (By similarity)

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRIG3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LRIG3 (see all 16):
    hsa-miR-3163 hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7g hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmid: LRIG3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRIG3 (see all 4)
    OriGene shRNA RFP: LRIG3
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for LRIG3

    In Situ Assay
    Products:       
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    Animal Models:
         Mouse knock-outs for LRIG3: Lrig3tm1.1Good Lrig3tm1Lex
         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Lrig3):
     behavior/neurological  craniofacial  hearing/vestibular/ear  no phenotypic analysis 

    LRIG3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LRIG3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRIG3

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--


    LRIG3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LRIG3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for LRIG3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    L189 DNA ligase I, III and IV inhibitor [64232-83-3]
    Search CenterWatch for drugs/clinical trials and news about LRIG3 

    Transcripts
    for LRIG3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LRIG3 gene (2 alternative transcripts): 
    NM_001136051.2  NM_153377.4  

    Unigene Cluster for LRIG3:

    Leucine-rich repeats and immunoglobulin-like domains 3
    Hs.744190  [show with all ESTs]
    Unigene Representative Sequence: NM_153377
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379141(uc009zqh.3) ENST00000320743(uc001sqr.3 uc010ssh.2)
    ENST00000433272 ENST00000550825 ENST00000552646 ENST00000547329 ENST00000550304
    ENST00000552267 ENST00000548968

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRIG3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LRIG3 (see all 16):
    hsa-miR-3163 hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7g hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmid: LRIG3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRIG3 (see all 4)
    OriGene shRNA RFP: LRIG3
    OriGene siRNA: LRIG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRIG3
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): LRIG3 (NM_001136051)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIG3 
    Primer
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    Additional cDNA sequence: 

    AK074921.1 AK130083.1 AK292857.1 AL833710.1 AY358288.1 AY358295.1 AY505340.1 BC012380.1 
    BC126169.1 BC126171.1 BC143960.1 

    8 DOTS entries:

    DT.101974026  DT.111907  DT.121210818  DT.121210807  DT.121210809  DT.121210822  DT.95266429  DT.86847794 

    24/80 AceView cDNA sequences (see all 80):

    AY505340 BQ448166 AW151968 AW517174 AL833710 AI809872 BI491023 BQ448139 
    BU742267 C16335 AW268159 AI683005 CA503064 AW151861 AW104416 AY358288 
    BX485770 AK074921 NM_153377 BQ446887 AI480372 BU787561 AK130083 BP355301 

    GeneLoc Exon Structure


    Expression
    for LRIG3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRIG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTATTTTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LRIG3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Primitive streak-like cells (Generation of endode...)
    Definitive endoderm-like cells (Generation of mesend...)
    Mesendoderm-like cells (Generation of mesend...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Mesoderm-like cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LRIG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRIG3

    SOURCE GeneReport for Unigene cluster: Hs.744190

    UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:     
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    Orthologs
    for LRIG3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LRIG3 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LRIG31 leucine-rich repeats and immunoglobulin-like domains more 76.06(n)
    79.05(a)    		   417813  NM_001199555.1  NP_001186484.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LRIG36
    		 --
    		 77(a)
    		 1 ↔ 1
    		 5(52596886-52617647)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ617624.12   -- 78.94(n)    BJ617624.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii lrig31 leucine-rich repeats and immunoglobulin-like domains more 64.77(n)
    67.93(a)    		   564554  NM_001110347.1  NP_001103817.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta lbk1 lambik 47.12(n)
    37.56(a)    		   36788  NM_137247.3  NP_611091.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea sma-101 Protein SMA-10 44.32(n)
    33.38(a)    		   176849  NM_067495.4  NP_499896.1 


    ENSEMBL Gene Tree for LRIG3 (if available)
    TreeFam Gene Tree for LRIG3 (if available) 

    Paralogs
    for LRIG3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LRIG3 gene
    FLRT12  GP52  CPN22  LRRTM42  CHAD2  FLRT32  LRRC152  LRIG22  
    LRRTM32  IGFALS2  CHADL2  LRIG12  LRRTM22  FLRT22  VASN2  LRRTM12  
    18/35 SIMAP similar genes for LRIG3 using alignment to 4 protein entries:     LRIG3_HUMAN (see all proteins) (see all similar genes):
    LRIG2    LRIG1    SLIT3    LRRC57    LRRC40    PXDN
    IGFALS    ISLR2    LRRC15    PXDNL    BGN    LGR6
    SLIT1    VASN    LINGO4    SCRIB    LGR4    LINGO2

    LRIG3 for paralogs           About GeneDecksing



    Genomic Variants
    for LRIG3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/927 NCBI SNPs in LRIG3 are shown (see all 927)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1470484251,2
    		--59265456(+) ACCTGA/GAACAG 2 -- int10--------
    rs1382474141,2
    		--59265465(+) AGTGCA/CTGAAA 2 -- int10--------
    rs1413551151,2
    		--59265495(+) ATTTTA/CGCTAT 2 -- int10--------
    rs1503664441,2
    		--59265544(+) GGGACA/GGCAAA 2 -- int10--------
    rs1867189201,2
    		--59265587(+) GACCAC/TGTAAA 2 -- int10--------
    rs1174983181,2
    		F,--59265680(+) CTTTTT/CTTGTT 2 -- int11Minor allele frequency- C:0.04EA 120
    rs1926229531,2
    		--59265691(+) CGTAGA/GTTTAG 2 -- int10--------
    rs800703531,2
    		--59265707(+) ATGTAA/CCTTAA 2 -- int10--------
    rs1832980051,2
    		--59265809(+) ACGGTC/TATTTT 2 -- int10--------
    rs111727871,2
    		C,F,--59266250(+) TATCCT/CTTTAA 2 -- ut31 ese35Minor allele frequency- C:0.03NA EA 382

    HapMap Linkage Disequilibrium report for LRIG3 (59265931 - 59314303 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for LRIG3
         2 CNVs: 35103 3892

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRIG3
    DNA2.0 Custom Variant and Variant Library Synthesis for LRIG3

    Disorders / Diseases
    for LRIG3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LRIG3 for disorders           About GeneDecksing

    OMIM gene information: 608870    OMIM disorders: --

    7 diseases for LRIG3:    About MalaCards
    pituitary adenoma    ependymoma    synovitis    adenoma
    pharyngitis    psoriasis    glioblastoma

    Human Genome Epidemiology (HuGE) Navigator: LRIG3 (5 documents)

    Export disorders for LRIG3 gene to outside databases

    Publications
    for LRIG3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRIG3 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with LRIG3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. (PubMed id 15203213)1, 2 Guo D.... Hedman H. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PubMed id 20446891)1 Andersson U....Melin B. (2010)
    6. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospecti ve meta-analysis from the cohorts for heart and aging research in genomic epide miology (CHARGE) consortium. (PubMed id 20445134)1 Smith N.L....Vasan R.S. (2010)
    7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    8. Inhibition of LRIG3 gene expression via RNA interference modulates the proliferation, cell cycle, cell apoptosis, adhesion and invasion of glioblastoma cell (GL15). (PubMed id 19200647)1 Cai M....Guo D. (2009)
    9. Effect of RNAi-mediated LRIG3 gene silencing on proli feration of glioma GL15 cells and expression of PCNA and Ki-67. (PubMed id 19448407)1 Cai M.J....Lei T. (2009)
    10. Expression of leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins in human ependymoma relates to tumor location, WHO grade, and patient age. (PubMed id 19216216)1 Yi W....Henriksson R. (2009)

    External Searches for LRIG3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing LRIG3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 121227 HGNC: 30991 AceView: LRIG3 Ensembl:ENSG00000139263 euGenes: HUgn121227
    ECgene: LRIG3 H-InvDB: LRIG3

    Other Databases showing LRIG3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA3016

    Specialized Databases showing LRIG3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRIG3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LRIG3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LRIG3 gene:
    Search GeneIP for patents involving LRIG3

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