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LRIG3 Gene

protein-coding   GIFtS: 49
GCID: GC12M059265

Leucine-Rich Repeats And Immunoglobulin-Like Domains 3

  Search for LRIG3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine-Rich Repeats And Immunoglobulin-Like Domains 31 2
LIG32 3 5
LIG-32 3
Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 32
LIRG35

External Ids:    HGNC: 309911   Entrez Gene: 1212272   Ensembl: ENSG000001392637   OMIM: 6088705   UniProtKB: Q6UXM13   

Export aliases for LRIG3 gene to outside databases

Previous GC identifers: GC12M057553 GC12M057554 GC12M056314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRIG3 Gene:
LRIG3 (leucine-rich repeats and immunoglobulin-like domains 3) is a protein-coding gene. An important paralog of this gene is GP5.

UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within
the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by
restricting the expression of NTN1 (By similarity)

summary for LRIG3 Gene:
Ligases catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or
a similar triphosphate. They belong to the E.C. 6 class, which also includes synthases and carboxylases. DNA
ligases play an integral role in DNA repair and replication: they catalyze the formation of phosphodiester
bonds, using ATP as a co-factor. These enzymes are divided into three classes: DNA ligase I, III and IV. DNA
ligase I links Okazaki fragments to form a continuous strand of DNA. DNA ligase III is involved in base
excision repair. Finally, DNA ligase IV is involved in the repair of DNA double-strand breaks by
non-homologous end joining (NHEJ).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRIG3 gene promoter:
         MEF-2A   FOXD3   aMEF-2   Nkx2-5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRIG3 promoter sequence
   Search Chromatin IP Primers for LRIG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRIG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q13.2

LRIG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRIG3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M059265:  view genomic region     (about GC identifiers)

Start:
59,265,931 bp from pter      End:
59,314,303 bp from pter
Size:
48,373 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1 (See protein sequence)
Recommended Name: Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor  
Size: 1119 amino acids; 123434 Da
Subunit: Interacts with EGFR, ERBB2 and ERBB4 (in vitro) (By similarity)
Sequence caution: Sequence=BAC11295.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6UXL7 Q8NC72
Alternative splicing: 2 isoforms:  Q6UXM1-1   Q6UXM1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRIG3: NX_Q6UXM1

Explore proteomics data for LRIG3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn122, Asn156, Asn274, Asn442, Asn469, Asn515, Asn688, Asn729, Asn905, Asn987,
                                 Asn999, Asn1016
  • Modification sites at PhosphoSitePlus

  • See LRIG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129523.1  NP_700356.2  

    ENSEMBL proteins: 
     ENSP00000368436   ENSP00000326759   ENSP00000413143   ENSP00000449169   ENSP00000449109  

    LRIG3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for LRIG3
    OriGene Custom MassSpec
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    Novus Biologicals LRIG3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRIG3

     
    Search eBioscience for Proteins for LRIG3 

    LRIG3 Antibody Products:

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    Novus Biologicals LRIG3 Antibodies
    Search for Antibodies for LRIG3 at Abcam
    Cloud-Clone Corp. Antibodies for LRIG3
    Search ThermoFisher Antibodies for LRIG3
    Search LSBio for Antibodies for LRIG3

    LRIG3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for LRIG3
    Cloud-Clone Corp. CLIAs for LRIG3
    Search eBioscience for ELISAs for LRIG3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 10):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q6UXM1

    ProtoNet protein and cluster: Q6UXM1

    4 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 15 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with LRIG3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRIG3_HUMAN, Q6UXM1
    Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within
    the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by
    restricting the expression of NTN1 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRIG3           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Lrig3):
     behavior/neurological  craniofacial  hearing/vestibular/ear  mortality/aging  no phenotypic analysis 
     skeleton  vision/eye 

    Find genes that share phenotypes with LRIG3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LRIG3: Lrig3tm1.1Good Lrig3tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRIG3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRIG3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRIG3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRIG3

    miRNA
    Products:
        
    miRTarBase miRNAs that target LRIG3:
    hsa-mir-374b-5p (MIRT016034), hsa-let-7f-5p (MIRT051405), hsa-mir-99a-5p (MIRT048604), hsa-mir-27b-3p (MIRT046227), hsa-mir-19b-3p (MIRT031125), hsa-mir-18a-5p (MIRT050669), hsa-mir-93-3p (MIRT038852)

    Block miRNA regulation of human, mouse, rat LRIG3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRIG3 (see all 16):
    hsa-miR-3163 hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7g hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmidLRIG3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRIG3
    Predesigned siRNA for gene silencing in human, mouse, rat LRIG3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRIG3

    Clone
    Products:
         
    OriGene clones in human, mouse for LRIG3 (see all 13)
    OriGene ORF clones in mouse, rat for LRIG3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LRIG3 (NM_001136051)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRIG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIG3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LRIG3
    Browse ESI BIO Cell Lines and PureStem Progenitors for LRIG3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIG3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRIG3_HUMAN, Q6UXM1: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle
    membrane; Single-pass type I membrane protein (By similarity). Note=Detected in cytoplasmic vesicles when
    coexpressed with ERBB4 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytosol1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    Find genes that share ontologies with LRIG3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LRIG3
        DNA Repair Mechanisms
    Nucleotide Excision Repair Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRIG3
    Interactions:

        Search GeneGlobe Interaction Network for LRIG3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for LRIG3 (ENSP000003267594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYD88ENSP000003796254STRING: ENSP00000379625
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--

    Find genes that share ontologies with LRIG3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for LRIG3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    L189 DNA ligase I, III and IV inhibitor [64232-83-3]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRIG3 gene (2 alternative transcripts): 
    NM_001136051.2  NM_153377.4  

    Unigene Cluster for LRIG3:

    Leucine-rich repeats and immunoglobulin-like domains 3
    Hs.253736  [show with all ESTs]
    Unigene Representative Sequence: AB795248
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379141(uc009zqh.3) ENST00000320743(uc001sqr.3 uc010ssh.2)
    ENST00000433272 ENST00000550825 ENST00000552646 ENST00000547329 ENST00000550304
    ENST00000552267 ENST00000548968
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRIG3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRIG3 (see all 16):
    hsa-miR-3163 hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7g hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmidLRIG3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRIG3
    Predesigned siRNA for gene silencing in human, mouse, rat LRIG3
    Clone
    Products:
         
    OriGene clones in human, mouse for LRIG3 (see all 13)
    OriGene ORF clones in mouse, rat for LRIG3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LRIG3 (NM_001136051)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRIG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIG3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LRIG3
    OriGene qSTAR qPCR primer pairs in human, mouse for LRIG3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRIG3
      QuantiTect SYBR Green Assays in human, mouse, rat LRIG3
      QuantiFast Probe-based Assays in human, mouse, rat LRIG3

    Additional mRNA sequence: 

    AB795247.1 AB795248.1 AK074921.1 AK130083.1 AK292857.1 AL833710.1 AY358288.1 AY358295.1 
    AY505340.1 BC012380.1 BC126169.1 BC126171.1 BC143960.1 

    8 DOTS entries:

    DT.101974026  DT.111907  DT.121210818  DT.121210807  DT.121210809  DT.121210822  DT.95266429  DT.86847794 

    Selected AceView cDNA sequences (see all 80):

    AI480372 BC012380 AW151861 AL833710 AK074921 AI809872 C16335 AI683005 
    AW268159 NM_153377 BX485770 AW263340 BQ448139 BQ448166 BU742267 AW517174 
    AW151968 CK430050 AW104416 AY358288 CA503064 BU787561 BQ446887 AY358295 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRIG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATTTTAT
    LRIG3 Expression
    About this image


    LRIG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Primitive streak-like cells
     
     NULL (Uncategorized)
             Mesoderm-like cells
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    LRIG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRIG3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.253736

    UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
    Tissue specificity: Widely expressed

        Custom PCR Arrays for LRIG3
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    QuantiTect SYBR Green Assays in human, mouse, rat LRIG3
    QuantiFast Probe-based Assays in human, mouse, rat LRIG3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LRIG3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrig31 , 5 leucine-rich repeats and immunoglobulin-like domains more1, 5 83.65(n)1
    86.12(a)1
      10 (73.66 cM)5
    3203981  NM_177152.51  NP_796126.41 
     1259662195 
    chicken
    (Gallus gallus)
    Aves LRIG31 leucine-rich repeats and immunoglobulin-like domains more 76.06(n)
    79.05(a)
      417813  NM_001199555.1  NP_001186484.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRIG36
    leucine-rich repeats and immunoglobulin-like domai...
    75(a)
    1 ↔ 1
    5(52537213-52620791)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ617624.12   -- 78.94(n)    BJ617624.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrig31 leucine-rich repeats and immunoglobulin-like domains more 64.84(n)
    68.13(a)
      564554  NM_001110347.1  NP_001103817.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lbk1 lambik 47.47(n)
    38.48(a)
      36788  NM_137247.3  NP_611091.2 
    worm
    (Caenorhabditis elegans)
    Secernentea sma-101 sma-10 44.38(n)
    33.56(a)
      176849  NM_067495.5  NP_499896.1 


    ENSEMBL Gene Tree for LRIG3 (if available)
    TreeFam Gene Tree for LRIG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRIG3 gene
    GP52  CPN22  LRRTM42  CHAD2  LRRC152  LRIG22  LRRTM32  IGFALS2  
    CHADL2  LRIG12  LRRTM22  LRRTM12  LRG12  
    Selected SIMAP similar genes for LRIG3 using alignment to 4 protein entries:     LRIG3_HUMAN (see all proteins) (see all similar genes):
    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1    LRIG2    LRIG1    SLIT3    LRRC57
    LRRC40    PXDN    IGFALS    ISLR2    LRRC15    PXDNL
    BGN    LGR4    LGR6    SLIT1    VASN    LINGO4

    Find genes that share paralogs with LRIG3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRIG3 (see all 1134)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470484251,2
    --59265456(+) ACCTGA/GAACAG 2 -- int10--------
    rs1382474141,2
    --59265465(+) AGTGCA/CTGAAA 2 -- int10--------
    rs1413551151,2
    --59265495(+) ATTTTA/CGCTAT 2 -- int10--------
    rs1503664441,2
    C--59265544(+) GGGACA/GGCAAA 2 -- int10--------
    rs1867189201,2
    --59265587(+) GACCAC/TGTAAA 2 -- int10--------
    rs1174983181,2
    F--59265680(+) CTTTTT/CTTGTT 2 -- int11Minor allele frequency- C:0.04EA 120
    rs1926229531,2
    --59265691(+) CGTAGA/GTTTAG 2 -- int10--------
    rs800703531,2
    --59265707(+) ATGTAA/CCTTAA 2 -- int10--------
    rs1832980051,2
    --59265809(+) ACGGTC/TATTTT 2 -- int10--------
    rs111727871,2
    C,F--59266250(+) TATCCT/CTTTAA 2 -- ut31 ese35Minor allele frequency- C:0.03NA EA 382

    HapMap Linkage Disequilibrium report for LRIG3 (59265931 - 59314303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LRIG3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv733CNV Insertion18451855
    dgv514e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRIG3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608870    OMIM disorders: --


    Find genes that share disorders with LRIG3           About GenesLikeMe

    Genetic Association Database (GAD): LRIG3
    Human Genome Epidemiology (HuGE) Navigator: LRIG3 (5 documents)

    Export disorders for LRIG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRIG3 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with LRIG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PubMed id 20446891)1, 4 Andersson U....Melin B. (Acta Oncol 2010)
    3. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PubMed id 20445134)1, 4 Smith N.L....Vasan R.S. (Circ Cardiovasc Genet 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. (PubMed id 15203213)1, 2 Guo D.... Hedman H. (Genomics 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3). (PubMed id 23723069)1 Rafidi H....Sweeney C. (J. Biol. Chem. 2013)
    8. Expression of LRIG1 and LRIG3 correlates with human papillomavirus status and patient survival in cervical adenocarcinoma. (PubMed id 23165628)1 Muller S....Andersson S. (Int. J. Oncol. 2013)
    9. Effect of silencing LRIG3 gene on the proliferation and apoptosis of bladder cancer T24 cells. (PubMed id 21505989)1 Yuan X....Ye Z. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121227 HGNC: 30991 AceView: LRIG3 Ensembl:ENSG00000139263 euGenes: HUgn121227
    ECgene: LRIG3 H-InvDB: LRIG3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRIG3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LRIG3 gene:
    Search GeneIP for patents involving LRIG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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