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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRIG3 Gene

protein-coding   GIFtS: 46
GCID: GC12M059265

Leucine-Rich Repeats And Immunoglobulin-Like Domains 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine-Rich Repeats And Immunoglobulin-Like Domains 31 2
LIG32 3 5
LIG-32 3
Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 32
LIRG35

External Ids:    HGNC: 309911   Entrez Gene: 1212272   Ensembl: ENSG000001392637   OMIM: 6088705   UniProtKB: Q6UXM13   

Export aliases for LRIG3 gene to outside databases

Previous GC identifers: GC12M057553 GC12M057554 GC12M056314


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LRIG3 Gene: 
LRIG3 (leucine-rich repeats and immunoglobulin-like domains 3) is a protein-coding gene. Diseases associated with LRIG3 include ependymoma, and synovitis. An important paralog of this gene is NYX.

UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within
the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by
restricting the expression of NTN1 (By similarity)

summary for LRIG3 Gene:
Ligases catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or
a similar triphosphate. They belong to the E.C. 6 class, which also includes synthases and carboxylases. DNA
ligases play an integral role in DNA repair and replication: they catalyze the formation of phosphodiester
bonds, using ATP as a co-factor. These enzymes are divided into three classes: DNA ligase I, III and IV. DNA
ligase I links Okazaki fragments to form a continuous strand of DNA. DNA ligase III is involved in base
excision repair. Finally, DNA ligase IV is involved in the repair of DNA double-strand breaks by
non-homologous end joining (NHEJ).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRIG3 gene promoter:
         MEF-2A   FOXD3   aMEF-2   Nkx2-5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRIG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRIG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRIG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q13.2

LRIG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRIG3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M059265:  view genomic region     (about GC identifiers)

Start:
59,265,931 bp from pter      End:
59,314,303 bp from pter
Size:
48,373 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1 (See protein sequence)
Recommended Name: Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor  
Size: 1119 amino acids; 123434 Da
Subunit: Interacts with EGFR, ERBB2 and ERBB4 (in vitro) (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle
membrane; Single-pass type I membrane protein (By similarity). Note=Detected in cytoplasmic vesicles when
coexpressed with ERBB4 (By similarity)
Sequence caution: Sequence=BAC11295.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6UXL7 Q8NC72
Alternative splicing: 2 isoforms:  Q6UXM1-1   Q6UXM1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRIG3: NX_Q6UXM1

Explore proteomics data for LRIG3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UXM1

  • LRIG3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRIG3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129523.1  NP_700356.2  

    ENSEMBL proteins: 
     ENSP00000368436   ENSP00000326759   ENSP00000413143   ENSP00000449169   ENSP00000449109  

    Human Recombinant Protein Products for LRIG3: 
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    Novus Biologicals LRIG3 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRIG3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0030659cytoplasmic vesicle membrane IEA--

    LRIG3 for ontologies           About GeneDecksing



    LRIG3 Antibody Products: 
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    Assay Products for LRIG3: 
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    Cloud-Clone Corp. ELISAs for LRIG3 
    Cloud-Clone Corp. CLIAs for LRIG3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    5/10 InterPro protein domains (see all 10):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q6UXM1

    ProtoNet protein and cluster: Q6UXM1

    4 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 15 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    LRIG3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRIG3_HUMAN, Q6UXM1
    Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within
    the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by
    restricting the expression of NTN1 (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    LRIG3 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Lrig3):
     behavior/neurological  craniofacial  hearing/vestibular/ear  no phenotypic analysis 

    LRIG3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LRIG3: Lrig3tm1.1Good Lrig3tm1Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRIG3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRIG3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRIG3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRIG3 

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LRIG3 (see all 16):
    hsa-miR-3163 hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7g hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmidLRIG3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of LRIG3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIG3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRIG3

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--

    LRIG3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for LRIG3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    L189 DNA ligase I, III and IV inhibitor [64232-83-3]

    Search CenterWatch for drugs/clinical trials and news about LRIG3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRIG3 gene (2 alternative transcripts): 
    NM_001136051.2  NM_153377.4  

    Unigene Cluster for LRIG3:

    Leucine-rich repeats and immunoglobulin-like domains 3
    Hs.253736  [show with all ESTs]
    Unigene Representative Sequence: AB795248
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379141(uc009zqh.3) ENST00000320743(uc001sqr.3 uc010ssh.2)
    ENST00000433272 ENST00000550825 ENST00000552646 ENST00000547329 ENST00000550304
    ENST00000552267 ENST00000548968
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRIG3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate LRIG3 (see all 16):
    hsa-miR-3163 hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7g hsa-miR-196a
    SwitchGear 3'UTR luciferase reporter plasmidLRIG3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRIG3
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRIG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIG3
    Sirion Biotech Customized lentivirus for stable overexpression of LRIG3 
                         Customized lentivirus expression plasmids for stable overexpression of LRIG3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LRIG3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRIG3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRIG3

    Additional mRNA sequence: 

    AB795247.1 AB795248.1 AK074921.1 AK130083.1 AK292857.1 AL833710.1 AY358288.1 AY358295.1 
    AY505340.1 BC012380.1 BC126169.1 BC126171.1 BC143960.1 

    8 DOTS entries:

    DT.101974026  DT.111907  DT.121210818  DT.121210807  DT.121210809  DT.121210822  DT.95266429  DT.86847794 

    24/80 AceView cDNA sequences (see all 80):

    AY505340 AY358288 BI491023 CK430050 BC012380 BP355301 NM_153377 AK130083 
    BU742267 AY358295 BQ448139 AL833710 CA503064 C16335 AW104416 AW268159 
    AW151861 AK074921 BQ448166 BU787561 AI809872 BX485770 AW517174 AW151968 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRIG3 expression in normal human tissues (normalized intensities)      LRIG3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATTTTAT
    LRIG3 Expression
    About this image


    LRIG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Primitive streak-like cells ( Generation of endoderm cells and pancreatic progenitor...
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H7 (WA07)
     
     Lung (Respiratory System)
             trachea   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End

    See LRIG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRIG3

    SOURCE GeneReport for Unigene cluster: Hs.253736

    UniProtKB/Swiss-Prot: LRIG3_HUMAN, Q6UXM1
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for LRIG3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LRIG3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrig31 , 5 leucine-rich repeats and immunoglobulin-like domains more1, 5 83.74(n)1
    86.12(a)1
      10 (73.66 cM)5
    3203981  NM_177152.51  NP_796126.41 
     1259662195 
    chicken
    (Gallus gallus)
    Aves LRIG31 leucine-rich repeats and immunoglobulin-like domains more 76.06(n)
    79.05(a)
      417813  NM_001199555.1  NP_001186484.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRIG36
    leucine-rich repeats and immunoglobulin-like domai...
    75(a)
    1 ↔ 1
    5(52537213-52620791)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ617624.12   -- 78.94(n)    BJ617624.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrig31 leucine-rich repeats and immunoglobulin-like domains more 64.77(n)
    67.93(a)
      564554  NM_001110347.1  NP_001103817.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lbk1 lambik 47.12(n)
    37.56(a)
      36788  NM_137247.3  NP_611091.2 
    worm
    (Caenorhabditis elegans)
    Secernentea sma-101 Protein SMA-10 44.32(n)
    33.38(a)
      176849  NM_067495.4  NP_499896.1 


    ENSEMBL Gene Tree for LRIG3 (if available)
    TreeFam Gene Tree for LRIG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LRIG3 gene
    NYX2  GP52  CPN22  LRRTM42  LRRC152  CHAD2  LRIG22  LRRTM32  
    IGFALS2  CHADL2  LRIG12  LRRTM22  RTN4R2  LRRC702  RTN4RL12  LRRTM12  
    RTN4RL22  LRG12  
    18/36 SIMAP similar genes for LRIG3 using alignment to 4 protein entries:     LRIG3_HUMAN (see all proteins) (see all similar genes):
    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1    LRIG2    LRIG1    SLIT3    LRRC57
    LRRC40    PXDN    IGFALS    ISLR2    LRRC15    PXDNL
    BGN    LGR4    LGR6    SLIT1    VASN    LINGO4

    LRIG3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1134 SNPs in LRIG3 are shown (see all 1134)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470484251,2
    --59265456(+) ACCTGA/GAACAG 2 -- int10--------
    rs1382474141,2
    --59265465(+) AGTGCA/CTGAAA 2 -- int10--------
    rs1413551151,2
    --59265495(+) ATTTTA/CGCTAT 2 -- int10--------
    rs1503664441,2
    C--59265544(+) GGGACA/GGCAAA 2 -- int10--------
    rs1867189201,2
    --59265587(+) GACCAC/TGTAAA 2 -- int10--------
    rs1174983181,2
    F--59265680(+) CTTTTT/CTTGTT 2 -- int11Minor allele frequency- C:0.04EA 120
    rs1926229531,2
    --59265691(+) CGTAGA/GTTTAG 2 -- int10--------
    rs800703531,2
    --59265707(+) ATGTAA/CCTTAA 2 -- int10--------
    rs1832980051,2
    --59265809(+) ACGGTC/TATTTT 2 -- int10--------
    rs111727871,2
    C,F--59266250(+) TATCCT/CTTTAA 2 -- ut31 ese35Minor allele frequency- C:0.03NA EA 382

    HapMap Linkage Disequilibrium report for LRIG3 (59265931 - 59314303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LRIG3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv733CNV Insertion18451855
    dgv514e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608870    OMIM disorders: --

    6 diseases for LRIG3:    About MalaCards
    ependymoma    synovitis    pituitary adenoma    psoriasis
    adenoma    glioblastoma


    LRIG3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LRIG3
    Human Genome Epidemiology (HuGE) Navigator: LRIG3 (5 documents)

    Export disorders for LRIG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRIG3 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with LRIG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PubMed id 20446891)1, 4 Andersson U....Melin B. (2010)
    3. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospecti ve meta-analysis from the cohorts for heart and aging research in genomic epide miology (CHARGE) consortium. (PubMed id 20445134)1, 4 Smith N.L....Vasan R.S. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. (PubMed id 15203213)1, 2 Guo D.... Hedman H. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Effect of silencing LRIG3 gene on the proliferation an d apoptosis of bladder cancer T24 cells. (PubMed id 21505989)1 Yuan X....Ye Z. (2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    9. Inhibition of LRIG3 gene expression via RNA interference modulates the proliferation, cell cycle, cell apoptosis, adhesion and invasion of glioblastoma cell (GL15). (PubMed id 19200647)1 Cai M....Guo D. (2009)
    10. Effect of RNAi-mediated LRIG3 gene silencing on proli feration of glioma GL15 cells and expression of PCNA and Ki-67. (PubMed id 19448407)1 Cai M.J....Lei T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 121227 HGNC: 30991 AceView: LRIG3 Ensembl:ENSG00000139263 euGenes: HUgn121227
    ECgene: LRIG3 H-InvDB: LRIG3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRIG3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LRIG3 gene:
    Search GeneIP for patents involving LRIG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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