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Aliases for LRIG3 Gene

Aliases for LRIG3 Gene

  • Leucine-Rich Repeats And Immunoglobulin-Like Domains 3 2 3
  • LIG3 3 4 6
  • LIG-3 3 4
  • Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 3 3
  • LIRG3 6

External Ids for LRIG3 Gene

Previous GeneCards Identifiers for LRIG3 Gene

  • GC12M057553
  • GC12M057554
  • GC12M059265
  • GC12M056314

Summaries for LRIG3 Gene

GeneCards Summary for LRIG3 Gene

LRIG3 (Leucine-Rich Repeats And Immunoglobulin-Like Domains 3) is a Protein Coding gene. Among its related pathways are Chks in Checkpoint Regulation and DNA Repair. An important paralog of this gene is LRRTM2.

UniProtKB/Swiss-Prot for LRIG3 Gene

  • May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIG3 Gene

Genomics for LRIG3 Gene

Regulatory Elements for LRIG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRIG3 Gene

Start:
58,872,149 bp from pter
End:
58,920,538 bp from pter
Size:
48,390 bases
Orientation:
Minus strand

Genomic View for LRIG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRIG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRIG3 Gene

Proteins for LRIG3 Gene

  • Protein details for LRIG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXM1-LRIG3_HUMAN
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 3
    Protein Accession:
    Q6UXM1
    Secondary Accessions:
    • Q6UXL7
    • Q8NC72

    Protein attributes for LRIG3 Gene

    Size:
    1119 amino acids
    Molecular mass:
    123434 Da
    Quaternary structure:
    • Interacts with EGFR, ERBB2 and ERBB4 (in vitro).
    SequenceCaution:
    • Sequence=BAC11295.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRIG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRIG3 Gene

Proteomics data for LRIG3 Gene at MOPED

Post-translational modifications for LRIG3 Gene

  • Glycosylation at Asn122, Asn156, Asn274, Asn442, Asn469, Asn515, Asn688, Asn729, Asn905, Asn987, Asn999, and Asn1016
  • Modification sites at PhosphoSitePlus

Other Protein References for LRIG3 Gene

No data available for DME Specific Peptides for LRIG3 Gene

Domains for LRIG3 Gene

Gene Families for LRIG3 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

Suggested Antigen Peptide Sequences for LRIG3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UXM1

UniProtKB/Swiss-Prot:

LRIG3_HUMAN :
  • Q6UXM1
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRIG3: view

Function for LRIG3 Gene

Molecular function for LRIG3 Gene

UniProtKB/Swiss-Prot Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).

Gene Ontology (GO) - Molecular Function for LRIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRIG3: view
genes like me logo Genes that share phenotypes with LRIG3: view

Animal Models for LRIG3 Gene

MGI Knock Outs for LRIG3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LRIG3 Gene

Localization for LRIG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIG3 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRIG3 Gene COMPARTMENTS Subcellular localization image for LRIG3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with LRIG3: view

Pathways for LRIG3 Gene

genes like me logo Genes that share pathways with LRIG3: view

Pathways by source for LRIG3 Gene

Interacting Proteins for LRIG3 Gene

Gene Ontology (GO) - Biological Process for LRIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032474 otolith morphogenesis IEA --
genes like me logo Genes that share ontologies with LRIG3: view

Transcripts for LRIG3 Gene

Unigene Clusters for LRIG3 Gene

Leucine-rich repeats and immunoglobulin-like domains 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRIG3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRIG3 Gene

No ASD Table

Relevant External Links for LRIG3 Gene

GeneLoc Exon Structure for
LRIG3
ECgene alternative splicing isoforms for
LRIG3

Expression for LRIG3 Gene

mRNA expression in normal human tissues for LRIG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRIG3 Gene

SOURCE GeneReport for Unigene cluster for LRIG3 Gene Hs.253736

mRNA Expression by UniProt/SwissProt for LRIG3 Gene

Q6UXM1-LRIG3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with LRIG3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LRIG3 Gene

Orthologs for LRIG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRIG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRIG3 35
  • 99.29 (n)
  • 99.46 (a)
LRIG3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRIG3 35
  • 89.19 (n)
  • 91.15 (a)
LRIG3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRIG3 35
  • 90.93 (n)
  • 94.42 (a)
LRIG3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrig3 35
  • 83.65 (n)
  • 86.12 (a)
Lrig3 16
Lrig3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRIG3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRIG3 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrig3 35
  • 83.93 (n)
  • 87.1 (a)
chicken
(Gallus gallus)
Aves LRIG3 35
  • 76.06 (n)
  • 79.05 (a)
LRIG3 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRIG3 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrig3 35
  • 69.98 (n)
  • 71.17 (a)
zebrafish
(Danio rerio)
Actinopterygii lrig3 35
  • 64.84 (n)
  • 68.13 (a)
LRIG3 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009688 35
  • 27.09 (n)
  • 9.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta lbk 35
  • 47.47 (n)
  • 38.48 (a)
lbk 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sma-10 35
  • 44.38 (n)
  • 33.56 (a)
sma-10 36
  • 29 (a)
OneToMany
Species with no ortholog for LRIG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRIG3 Gene

ENSEMBL:
Gene Tree for LRIG3 (if available)
TreeFam:
Gene Tree for LRIG3 (if available)

Paralogs for LRIG3 Gene

Paralogs for LRIG3 Gene

genes like me logo Genes that share paralogs with LRIG3: view

Variants for LRIG3 Gene

Sequence variations from dbSNP and Humsavar for LRIG3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs720052 -- 58,908,439(-) GACTT(C/T)GGTGT intron-variant
rs748822 -- 58,888,743(+) TTCAC(A/G/T)TAAGA intron-variant
rs1020031 -- 58,901,672(+) GGAGA(A/G)GGGAA intron-variant
rs1144546 -- 58,879,553(+) CTGTT(C/T)TATGT intron-variant
rs1391022 -- 58,919,831(-) CGGGC(C/T)TCAGT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRIG3 Gene

Variant ID Type Subtype PubMed ID
dgv514e1 CNV Complex 17122850
nsv733 CNV Insertion 18451855

Relevant External Links for LRIG3 Gene

HapMap Linkage Disequilibrium report
LRIG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRIG3 Gene

Disorders for LRIG3 Gene

Relevant External Links for LRIG3

Genetic Association Database (GAD)
LRIG3
Human Genome Epidemiology (HuGE) Navigator
LRIG3
genes like me logo Genes that share disorders with LRIG3: view

No data available for UniProtKB/Swiss-Prot for LRIG3 Gene

Publications for LRIG3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. (PMID: 15203213) Guo D. … Hedman H. (Genomics 2004) 3 4
  4. A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PMID: 20446891) Andersson U. … Melin B. (Acta Oncol 2010) 3 48
  5. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. (PMID: 20445134) Smith N.L. … Vasan R.S. (Circ Cardiovasc Genet 2010) 3 48

Products for LRIG3 Gene

Sources for LRIG3 Gene

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