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Aliases for LRIG2 Gene

Aliases for LRIG2 Gene

  • Leucine-Rich Repeats And Immunoglobulin-Like Domains 2 2 3
  • LIG-2 3 4
  • LIG2 3 4
  • KIAA0806 4
  • UFS2 3

External Ids for LRIG2 Gene

Previous GeneCards Identifiers for LRIG2 Gene

  • GC01P112715
  • GC01P112914
  • GC01P113327
  • GC01P113417
  • GC01P113615
  • GC01P111474

Summaries for LRIG2 Gene

Entrez Gene Summary for LRIG2 Gene

  • This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

GeneCards Summary for LRIG2 Gene

LRIG2 (Leucine-Rich Repeats And Immunoglobulin-Like Domains 2) is a Protein Coding gene. Diseases associated with LRIG2 include lrig2-related urofacial syndrome and urofacial syndrome 2. An important paralog of this gene is LRRTM2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIG2 Gene

Genomics for LRIG2 Gene

Regulatory Elements for LRIG2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRIG2 Gene

113,073,170 bp from pter
113,132,260 bp from pter
59,091 bases
Plus strand

Genomic View for LRIG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for LRIG2 Gene

Proteins for LRIG2 Gene

  • Protein details for LRIG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 2
    Protein Accession:
    Secondary Accessions:
    • Q9NSN2

    Protein attributes for LRIG2 Gene

    1065 amino acids
    Molecular mass:
    118965 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34526.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for LRIG2 Gene

Proteomics data for LRIG2 Gene at MOPED

Post-translational modifications for LRIG2 Gene

  • Glycosylation at Asn 91, Asn 121, Asn 173, Asn 189, Asn 274, Asn 441, Asn 468, Asn 514, Asn 571, Asn 589, Asn 687, and Asn 728
  • Modification sites at PhosphoSitePlus

Other Protein References for LRIG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRIG2 Gene

Domains & Families for LRIG2 Gene

Gene Families for LRIG2 Gene

Suggested Antigen Peptide Sequences for LRIG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 15 LRR (leucine-rich) repeats.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRIG2: view

Function for LRIG2 Gene

Gene Ontology (GO) - Molecular Function for LRIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRIG2: view
genes like me logo Genes that share phenotypes with LRIG2: view

Animal Models for LRIG2 Gene

MGI Knock Outs for LRIG2:

Animal Model Products

miRNA for LRIG2 Gene

miRTarBase miRNAs that target LRIG2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LRIG2 Gene

Localization for LRIG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIG2 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

Jensen Localization Image for LRIG2 Gene COMPARTMENTS Subcellular localization image for LRIG2 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for LRIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRIG2: view

Pathways & Interactions for LRIG2 Gene

SuperPathways for LRIG2 Gene

No Data Available

Interacting Proteins for LRIG2 Gene

Gene Ontology (GO) - Biological Process for LRIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IEA --
GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway IEA --
GO:0060384 innervation IEA --
genes like me logo Genes that share ontologies with LRIG2: view

No data available for Pathways by source and SIGNOR curated interactions for LRIG2 Gene

Drugs & Compounds for LRIG2 Gene

No Compound Related Data Available

Transcripts for LRIG2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRIG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRIG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - -
SP2: - -
SP3: - - -
SP5: -

ExUns: 20a · 20b

Relevant External Links for LRIG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRIG2 Gene

mRNA expression in normal human tissues for LRIG2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRIG2 Gene

SOURCE GeneReport for Unigene cluster for LRIG2 Gene Hs.448972

mRNA Expression by UniProt/SwissProt for LRIG2 Gene

Tissue specificity: Detected in all tissues analyzed.
genes like me logo Genes that share expression patterns with LRIG2: view

Protein tissue co-expression partners for LRIG2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for LRIG2 Gene

Orthologs for LRIG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRIG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRIG2 35
  • 90.92 (n)
  • 91.83 (a)
LRIG2 36
  • 92 (a)
(Canis familiaris)
Mammalia LRIG2 35
  • 90.52 (n)
  • 92.02 (a)
LRIG2 36
  • 91 (a)
(Mus musculus)
Mammalia Lrig2 35
  • 87.95 (n)
  • 89.85 (a)
Lrig2 16
Lrig2 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Lrig2 35
  • 87.38 (n)
  • 89.85 (a)
(Monodelphis domestica)
Mammalia LRIG2 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia LRIG2 36
  • 86 (a)
(Pan troglodytes)
Mammalia LRIG2 36
  • 99 (a)
(Gallus gallus)
Aves LRIG2 35
  • 76.82 (n)
  • 81.57 (a)
LRIG2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia LRIG2 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrig2 35
  • 72.07 (n)
  • 73.64 (a)
(Danio rerio)
Actinopterygii lrig2 35
  • 64.69 (n)
  • 68.09 (a)
lrig2 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta lbk 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea sma-10 36
  • 28 (a)
Species with no ortholog for LRIG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRIG2 Gene

Gene Tree for LRIG2 (if available)
Gene Tree for LRIG2 (if available)

Paralogs for LRIG2 Gene

Paralogs for LRIG2 Gene

(4) SIMAP similar genes for LRIG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRIG2: view

Variants for LRIG2 Gene

Sequence variations from dbSNP and Humsavar for LRIG2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs749956 -- 113,125,215(-) GATAC(A/C)CTTCT downstream-variant-500B
rs946215 -- 113,084,072(+) gattt(C/G)tttgg intron-variant
rs1216767 -- 113,080,360(+) ATTCT(A/C)ATTTG intron-variant
rs1216768 -- 113,081,102(+) tccca(A/G)agtgc intron-variant
rs1216769 -- 113,081,887(+) CTCAT(C/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRIG2 Gene

Variant ID Type Subtype PubMed ID
esv24626 CNV Loss 19812545
nsv508537 CNV Loss 20534489
nsv437002 CNV Loss 16327808
nsv435694 CNV Deletion 17901297

Variation tolerance for LRIG2 Gene

Residual Variation Intolerance Score: 36.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRIG2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRIG2 Gene

Disorders for LRIG2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for LRIG2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lrig2-related urofacial syndrome
  • urofacial syndrome 2
urofacial syndrome 2
  • ufs2
urofacial syndrome 1
  • urofacial syndrome
  • unspecified lagophthalmos
neurogenic bladder
  • neurogenic bladder nos
- elite association
Search LRIG2 in MalaCards View complete list of genes associated with diseases


  • Urofacial syndrome 2 (UFS2) [MIM:615112]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. {ECO:0000269 PubMed:23313374}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LRIG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LRIG2: view

No data available for Genatlas for LRIG2 Gene

Publications for LRIG2 Gene

  1. Characterization and tissue-specific expression of human LRIG2. (PMID: 15145052) Holmlund C. … Hedman H. (Gene 2004) 23 67
  2. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. (PMID: 15203213) Guo D. … Hedman H. (Genomics 2004) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Soluble LRIG2 ectodomain is released from glioblastoma cells and promotes the proliferation and inhibits the apoptosis of glioblastoma cells in vitro and in vivo in a similar manner to the full-length LRIG2. (PMID: 25353163) Xiao Q. … Guo D. (PLoS ONE 2014) 67
  5. LRIG and cancer prognosis. (PMID: 25180912) Lindquist D. … Hedman H. (Acta Oncol 2014) 67

Products for LRIG2 Gene

Sources for LRIG2 Gene

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