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Aliases for LRIG2 Gene

Aliases for LRIG2 Gene

  • Leucine-Rich Repeats And Immunoglobulin Like Domains 2 2 3
  • Leucine-Rich Repeats And Immunoglobulin-Like Domains 2 3 5
  • LIG-2 3 4
  • LIG2 3 4
  • KIAA0806 4
  • UFS2 3

External Ids for LRIG2 Gene

Previous GeneCards Identifiers for LRIG2 Gene

  • GC01P112715
  • GC01P112914
  • GC01P113327
  • GC01P113417
  • GC01P113615
  • GC01P111474

Summaries for LRIG2 Gene

Entrez Gene Summary for LRIG2 Gene

  • This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

GeneCards Summary for LRIG2 Gene

LRIG2 (Leucine-Rich Repeats And Immunoglobulin Like Domains 2) is a Protein Coding gene. Diseases associated with LRIG2 include Urofacial Syndrome 2 and Urofacial Syndrome 1. An important paralog of this gene is LRRTM2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIG2 Gene

Genomics for LRIG2 Gene

Regulatory Elements for LRIG2 Gene

Enhancers for LRIG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRIG2 on UCSC Golden Path with GeneCards custom track

Promoters for LRIG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRIG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRIG2 Gene

Chromosome:
1
Start:
113,073,170 bp from pter
End:
113,132,260 bp from pter
Size:
59,091 bases
Orientation:
Plus strand

Genomic View for LRIG2 Gene

Genes around LRIG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRIG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRIG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRIG2 Gene

Proteins for LRIG2 Gene

  • Protein details for LRIG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94898-LRIG2_HUMAN
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 2
    Protein Accession:
    O94898
    Secondary Accessions:
    • Q9NSN2

    Protein attributes for LRIG2 Gene

    Size:
    1065 amino acids
    Molecular mass:
    118965 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34526.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for LRIG2 Gene

Proteomics data for LRIG2 Gene at MOPED

Post-translational modifications for LRIG2 Gene

  • Glycosylation at Asn 91, Asn 121, Asn 173, Asn 189, Asn 274, Asn 441, Asn 468, Asn 514, Asn 571, Asn 589, Asn 687, and Asn 728
  • Modification sites at PhosphoSitePlus

Other Protein References for LRIG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRIG2 Gene

Domains & Families for LRIG2 Gene

Gene Families for LRIG2 Gene

Suggested Antigen Peptide Sequences for LRIG2 Gene

Graphical View of Domain Structure for InterPro Entry

O94898

UniProtKB/Swiss-Prot:

LRIG2_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 15 LRR (leucine-rich) repeats.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRIG2: view

Function for LRIG2 Gene

genes like me logo Genes that share phenotypes with LRIG2: view

Human Phenotype Ontology for LRIG2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LRIG2 Gene

MGI Knock Outs for LRIG2:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRIG2

miRNA for LRIG2 Gene

miRTarBase miRNAs that target LRIG2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for LRIG2 Gene

Localization for LRIG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIG2 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRIG2 Gene COMPARTMENTS Subcellular localization image for LRIG2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for LRIG2 Gene

Pathways & Interactions for LRIG2 Gene

SuperPathways for LRIG2 Gene

No Data Available

Interacting Proteins for LRIG2 Gene

Gene Ontology (GO) - Biological Process for LRIG2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRIG2 Gene

Drugs & Compounds for LRIG2 Gene

No Compound Related Data Available

Transcripts for LRIG2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LRIG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4:
SP5: -

ExUns: 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for LRIG2 Gene

GeneLoc Exon Structure for
LRIG2
ECgene alternative splicing isoforms for
LRIG2

Expression for LRIG2 Gene

mRNA expression in normal human tissues for LRIG2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRIG2 Gene



SOURCE GeneReport for Unigene cluster for LRIG2 Gene Hs.448972

mRNA Expression by UniProt/SwissProt for LRIG2 Gene

O94898-LRIG2_HUMAN
Tissue specificity: Detected in all tissues analyzed.
genes like me logo Genes that share expression patterns with LRIG2: view

Protein tissue co-expression partners for LRIG2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for LRIG2 Gene

Orthologs for LRIG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRIG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRIG2 35
  • 90.92 (n)
  • 91.83 (a)
LRIG2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRIG2 35
  • 90.52 (n)
  • 92.02 (a)
LRIG2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrig2 35
  • 87.95 (n)
  • 89.85 (a)
Lrig2 16
Lrig2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrig2 35
  • 87.38 (n)
  • 89.85 (a)
oppossum
(Monodelphis domestica)
Mammalia LRIG2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRIG2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRIG2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRIG2 35
  • 76.82 (n)
  • 81.57 (a)
LRIG2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRIG2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrig2 35
  • 72.07 (n)
  • 73.64 (a)
zebrafish
(Danio rerio)
Actinopterygii lrig2 35
  • 64.69 (n)
  • 68.09 (a)
lrig2 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lbk 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sma-10 36
  • 28 (a)
OneToMany
Species with no ortholog for LRIG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRIG2 Gene

ENSEMBL:
Gene Tree for LRIG2 (if available)
TreeFam:
Gene Tree for LRIG2 (if available)

Paralogs for LRIG2 Gene

(4) SIMAP similar genes for LRIG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRIG2: view

Variants for LRIG2 Gene

Sequence variations from dbSNP and Humsavar for LRIG2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs749956 -- 113,125,215(-) GATAC(A/C)CTTCT downstream-variant-500B
rs946215 -- 113,084,072(+) gattt(C/G)tttgg intron-variant
rs1216767 -- 113,080,360(+) ATTCT(A/C)ATTTG intron-variant
rs1216768 -- 113,081,102(+) tccca(A/G)agtgc intron-variant
rs1216769 -- 113,081,887(+) CTCAT(C/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRIG2 Gene

Variant ID Type Subtype PubMed ID
esv24626 CNV Loss 19812545
nsv508537 CNV Loss 20534489
nsv437002 CNV Loss 16327808
nsv435694 CNV Deletion 17901297

Variation tolerance for LRIG2 Gene

Residual Variation Intolerance Score: 36.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRIG2 Gene

Human Gene Mutation Database (HGMD)
LRIG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRIG2 Gene

Disorders for LRIG2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for LRIG2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
urofacial syndrome 2
  • ufs2
urofacial syndrome 1
  • urofacial syndrome
lrig2-related urofacial syndrome
  • urofacial syndrome 2
lagophthalmos
neurogenic bladder
  • neurogenic dysfunction of the urinary bladder
- elite association - COSMIC cancer census association via MalaCards
Search LRIG2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LRIG2_HUMAN
  • Urofacial syndrome 2 (UFS2) [MIM:615112]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. {ECO:0000269 PubMed:23313374}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LRIG2

Genetic Association Database (GAD)
LRIG2
Human Genome Epidemiology (HuGE) Navigator
LRIG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRIG2
genes like me logo Genes that share disorders with LRIG2: view

No data available for Genatlas for LRIG2 Gene

Publications for LRIG2 Gene

  1. Characterization and tissue-specific expression of human LRIG2. (PMID: 15145052) Holmlund C. … Hedman H. (Gene 2004) 3 4 23 67
  2. The LRIG gene family has three vertebrate paralogs widely expressed in human and mouse tissues and a homolog in Ascidiacea. (PMID: 15203213) Guo D. … Hedman H. (Genomics 2004) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. LRIG2 expression and prognosis in non-small cell lung cancer. (PMID: 25013483) Wang G. … Song H. (Oncol Lett 2014) 3
  5. LRIG and cancer prognosis. (PMID: 25180912) Lindquist D. … Hedman H. (Acta Oncol 2014) 3

Products for LRIG2 Gene

Sources for LRIG2 Gene

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