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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRIG1 Gene

protein-coding   GIFtS: 60
GCID: GC03M066511

Leucine-Rich Repeats And Immunoglobulin-Like Domains 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine-Rich Repeats And Immunoglobulin-Like Domains 11 2
LIG12 3 5
Leucine-Rich Repeat Protein LRIG11 2
Ortholog Of Mouse Integral Membrane Glycoprotein LIG-11 2
LIG-12 3
Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 12

External Ids:    HGNC: 173601   Entrez Gene: 260182   Ensembl: ENSG000001447497   OMIM: 6088685   UniProtKB: Q96JA13   

Export aliases for LRIG1 gene to outside databases

Previous GC identifers: GC03M065048 GC03M065899 GC03M066259 GC03M066362


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LRIG1 Gene: 
LRIG1 (leucine-rich repeats and immunoglobulin-like domains 1) is a protein-coding gene. Diseases associated with LRIG1 include malignant glioma, and psoriasis. An important paralog of this gene is GP5.

UniProtKB/Swiss-Prot: LRIG1_HUMAN, Q96JA1
Function: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism
that involves enhancement of receptor ubiquitination and accelerated intracellular degradation

summary for LRIG1 Gene:
Ligases catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or
a similar triphosphate. They belong to the E.C. 6 class, which also includes synthases and carboxylases. DNA
ligases play an integral role in DNA repair and replication: they catalyze the formation of phosphodiester
bonds, using ATP as a co-factor. These enzymes are divided into three classes: DNA ligase I, III and IV. DNA
ligase I links Okazaki fragments to form a continuous strand of DNA. DNA ligase III is involved in base
excision repair. Finally, DNA ligase IV is involved in the repair of DNA double-strand breaks by
non-homologous end joining (NHEJ).

Gene Wiki entry for LRIG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022459.15  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRIG1 gene promoter:
         HFH-3   AML1a   CUTL1   FOXI1   SRY   POU2F1   POU2F1a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRIG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRIG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRIG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14

LRIG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRIG1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M066511:  view genomic region     (about GC identifiers)

Start:
66,429,221 bp from pter      End:
66,551,687 bp from pter
Size:
122,467 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LRIG1_HUMAN, Q96JA1 (See protein sequence)
Recommended Name: Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor  
Size: 1093 amino acids; 119113 Da
Subunit: Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q6IQ51 Q96CF9 Q9BYB8 Q9UFI4
Alternative splicing: 2 isoforms:  Q96JA1-1   Q96JA1-2   

Explore the universe of human proteins at neXtProt for LRIG1: NX_Q96JA1

Explore proteomics data for LRIG1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96JA1

  • LRIG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRIG1 Protein Expression
    REFSEQ proteins: NP_056356.2  
    ENSEMBL proteins: 
     ENSP00000273261   ENSP00000373208  

    Human Recombinant Protein Products for LRIG1: 
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    OriGene Protein Over-expression Lysate for LRIG1
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    Sino Biological Recombinant Protein for LRIG1
    Sino Biological Cell Lysate for LRIG1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRIG1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    LRIG1 for ontologies           About GeneDecksing



    LRIG1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for LRIG1 

    Assay Products for LRIG1: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRIG1 
    Cloud-Clone Corp. CLIAs for LRIG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    5/9 InterPro protein domains (see all 9):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q96JA1

    ProtoNet protein and cluster: Q96JA1

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: LRIG1_HUMAN, Q96JA1
    Domain: The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only
    when these two domains are deleted
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 15 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    LRIG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRIG1_HUMAN, Q96JA1
    Function: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism
    that involves enhancement of receptor ubiquitination and accelerated intracellular degradation
    Induction: By EGF

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    LRIG1 for ontologies           About GeneDecksing


    Phenotypes:
         15/16 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lrig1) (see all 16):
     adipose tissue  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  nervous system  normal  skeleton  tumorigenesis 

    LRIG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lrig1tm1Ita for LRIG1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRIG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRIG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRIG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRIG1 

    miRNA
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    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate LRIG1 (see all 90):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-15a hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-548a-5p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidLRIG1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for LRIG1
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                         Customized lentivirus expression plasmids for stable overexpression of LRIG1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIG1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LRIG1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Tyrosine Kinases / Adaptors
    Tyrosine Kinases / Adaptors
    2Internalization of ErbB1
    Internalization of ErbB1
    3ErbB4 signaling events
    ErbB4 signaling events
    4EGFR Signaling Pathway
    EGFR Signaling Pathway
    5Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for LRIG1
        Tyrosine Kinases / Adaptors
    Protein Stability

    2 BioSystems Pathways for LRIG1
        ErbB4 signaling events
    Internalization of ErbB1

    1 Sino Biological Pathway for LRIG1 
        EGFR Signaling Pathway



    LRIG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LRIG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for LRIG1 (Q96JA13 ENSP000002732614) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046263, ENSP000002695714I2D: score=1 STRING: ENSP00000269571
    METP085813, ENSP000003172724I2D: score=1 STRING: ENSP00000317272
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    ERBB4Q153033, ENSP000003422354I2D: score=1 STRING: ENSP00000342235
    CBLP226813, ENSP000002640334I2D: score=1 STRING: ENSP00000264033
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LRIG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for LRIG1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    L189 DNA ligase I, III and IV inhibitor [64232-83-3]

    1 Novoseek inferred chemical compound relationship for LRIG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 12.2 3 15345710 (2), 16168117 (1)

    Search CenterWatch for drugs/clinical trials and news about LRIG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRIG1 gene: 
    NM_015541.2  

    Unigene Cluster for LRIG1:

    Leucine-rich repeats and immunoglobulin-like domains 1
    Hs.518055  [show with all ESTs]
    Unigene Representative Sequence: BC071561
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273261(uc011bfu.2 uc010hnz.3 uc003dmx.3) ENST00000383703(uc010hoa.3)
    ENST00000496559(uc003dmw.3) ENST00000495037 ENST00000491821 ENST00000497721
    ENST00000498287 ENST00000475366 ENST00000495671
    miRNA
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    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate LRIG1 (see all 90):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-15a hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-548a-5p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidLRIG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRIG1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRIG1
    Clone
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    OriGene ORF clones in mouse, rat for LRIG1
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    GenScript: all cDNA clones in your preferred vector: LRIG1 (NM_015541)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRIG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIG1
    Sirion Biotech Customized lentivirus for stable overexpression of LRIG1 
                         Customized lentivirus expression plasmids for stable overexpression of LRIG1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRIG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRIG1

    Additional mRNA sequence: 

    AB050468.1 AF381545.1 AK126745.1 AK294984.1 AK314103.1 AL117666.1 AY730707.1 BC014276.2 
    BC071561.1 BC140907.1 

    22 DOTS entries:

    DT.95277669  DT.120856493  DT.100657532  DT.445915  DT.80100456  DT.75166641  DT.91640393  DT.91702182 
    DT.120856444  DT.92441117  DT.120856427  DT.120856432  DT.40131021  DT.40266393  DT.405663  DT.416947 
    DT.91742379  DT.92028647  DT.99929783  DT.99987979  DT.100761721  DT.120856464 

    24/194 AceView cDNA sequences (see all 194):

    BQ270606 AA716680 CA314737 BM994400 AI921637 AI280419 AI918941 BM971625 
    AI687886 AI884322 BE858828 AA350590 AI961225 AI858576 BM851113 AI915461 
    CA435021 AI216168 AI358990 AA642527 BC014276 AA931222 BM508156 AI051841 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for LRIG1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^
    SP1:                                                                    -           -     -     -                 -                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                              -                                             
    SP4:        -     -                                                                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for LRIG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRIG1 expression in normal human tissues (normalized intensities)      LRIG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATATTG
    LRIG1 Expression
    About this image


    LRIG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
             Septum   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Intervertebral Disc Annulus Fibrosus Cells Lumbar Intervertebral Disc
             Human Nucleus Pulposus Cells (HNPC)   
     
     Hair (Integumentary System)    fully expand to see all 4 entries
             Early Sebocytes Sebaceous Gland
             mouse/organ system/integumental system   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Retina
             Human corneal endothelial cells
             sensory organ/eye/cornea   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/atrium   

    See LRIG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRIG1

    SOURCE GeneReport for Unigene cluster: Hs.518055

    UniProtKB/Swiss-Prot: LRIG1_HUMAN, Q96JA1
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for LRIG1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LRIG1 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrig11 , 5 leucine-rich repeats and immunoglobulin-like domains more1, 5 83.67(n)1
    84.29(a)1
      6 (43.15 cM)5
    162061  NM_008377.21  NP_032403.21 
     946045295 
    chicken
    (Gallus gallus)
    Aves LRIG11 leucine-rich repeats and immunoglobulin-like domains more 72.5(n)
    72.57(a)
      427592  XM_425165.3  XP_425165.3 
    lizard
    (Anolis carolinensis)
    Reptilia LRIG16
    leucine-rich repeats and immunoglobulin-like domai...
    66(a)
    1 ↔ 1
    2(184389885-184555853)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX739790.12   -- 75.43(n)    BX739790.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrig11 leucine-rich repeats and immunoglobulin-like domains more 66.12(n)
    69.07(a)
      560325  XM_683725.5  XP_688817.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta lbk6
    CG180956
    (see all 5)
    --
    24(a)
    22(a)
    (see all 5)
    1 ↔ many
    possible ortholog
    (see all 5)
    2R(12037628-12057024)
    2L(14029262-14031539)
    worm
    (Caenorhabditis elegans)
    Secernentea sma-106
    sym-16
    Protein SYM-1
    28(a)
    21(a)
    1 ↔ many
    possible ortholog
    IV(274570-279949)
    X(14581654-14584368)


    ENSEMBL Gene Tree for LRIG1 (if available)
    TreeFam Gene Tree for LRIG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LRIG1 gene
    GP52  CPN22  LRRC152  LRRTM32  IGFALS2  LRRTM22  RTN4R2  LRRTM12  
    LRG12  NYX2  LRIG32  LRRTM42  CHAD2  LRIG22  CHADL2  RTN4RL12  
    LRRC702  RTN4RL22  
    6 SIMAP similar genes for LRIG1 using alignment to 2 protein entries:     LRIG1_HUMAN (see all proteins):
    LRIG3(NM_001136051)-ROS1    DCN    LRIG3(NM_153377)-ROS1    LRIG3    LRIG2    PTPRS

    LRIG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3027 SNPs in LRIG1 are shown (see all 3027)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496745101,2
    --66429885(+) CAATCA/GAATGA 1 -- ut310--------
    rs1456106781,2
    C--66429901(+) AGAAGA/GCCACA 1 -- ut310--------
    rs775703221,2
    C,F--66430010(+) CAGACG/AGACAG 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs340227901,2
    C,F--66430129(+) CAGGGG/CCATCC 1 -- ut312Minor allele frequency- C:0.19NA WA 124
    rs622432441,2
    F--66430174(+) GCGCAG/TGTGGA 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs1453100251,2
    C--66430186(+) TCCCAA/CCGCAC 1 -- ut310--------
    rs762804081,2
    C,F--66430215(+) GAAGTG/ACAATA 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs792035521,2
    C--66430236(+) GCCTTC/G/TCATCC 2 -- ut312CSA NA 121
    rs1853495491,2
    --66430250(+) CCACCC/GCGCAC 1 -- ut310--------
    rs38321891,2
    C--66430335(-) AGGGGG/-TGGGG 1 -- ut313Minor allele frequency- -:0.16MN EA NA 1254

    HapMap Linkage Disequilibrium report for LRIG1 (66429221 - 66551687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LRIG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2725370CNV Deletion23290073
    esv2725369CNV Deletion23290073
    esv2658504CNV Deletion23128226
    nsv516847CNV Loss19592680
    esv23340CNV Loss19812545
    nsv237304CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608868    OMIM disorders: --

    10 diseases for LRIG1:    About MalaCards
    malignant glioma    psoriasis    renal cell carcinoma    cervical cancer
    cervicitis    squamous cell carcinoma    colorectal cancer    prostate cancer
    prostatitis    breast cancer


    LRIG1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for LRIG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 10.6 2 12234026 (1), 16847455 (1)
    tumors 3.56 4 11414704 (1), 15345710 (1), 15871317 (1)

    Genetic Association Database (GAD): LRIG1
    Human Genome Epidemiology (HuGE) Navigator: LRIG1 (1 document)

    Export disorders for LRIG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRIG1 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with LRIG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, characterization, and expression of human LIG1. (PubMed id 11414704)1, 2, 3, 9 Nilsson J.... Hedman H. (2001)
    2. Is LRIG1 a tumour suppressor gene at chromosome 3p14.3? (PubMed id 12234026)1, 3, 9 Hedman H....Henriksson R. (2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Common variants in 22 loci are associated with QRS du ration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (2010)
    5. LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation. (PubMed id 15282549)1, 2 Gur G....Yarden Y. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Increased copy number at 3p14 in breast cancer. (PubMed id 16168117)1, 9 Ljuslinder I....Henriksson R. (2005)
    8. LRIG1 protein in human cells and tissues. (PubMed id 12684867)1, 9 Nilsson J....Hedman H. (2003)
    9. The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases. (PubMed id 15345710)1, 9 Laederich M.B.... Sweeney C. (2004)
    10. LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT--PCR and immunohistochemical analysis. (PubMed id 14520461)1, 9 Thomasson M....Henriksson R. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26018 HGNC: 17360 AceView: LRIG1 Ensembl:ENSG00000144749 euGenes: HUgn26018
    ECgene: LRIG1 H-InvDB: LRIG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRIG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LRIG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LRIG1 gene:
    Search GeneIP for patents involving LRIG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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