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Aliases for LRIG1 Gene

Aliases for LRIG1 Gene

  • Leucine-Rich Repeats And Immunoglobulin-Like Domains 1 2 3
  • LIG1 3 4 6
  • Ortholog Of Mouse Integral Membrane Glycoprotein LIG-1 2 3
  • Leucine-Rich Repeat Protein LRIG1 2 3
  • LIG-1 3 4
  • Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 1 3

External Ids for LRIG1 Gene

Summaries for LRIG1 Gene

GeneCards Summary for LRIG1 Gene

LRIG1 (Leucine-Rich Repeats And Immunoglobulin-Like Domains 1) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. An important paralog of this gene is LRRTM2.

UniProtKB/Swiss-Prot for LRIG1 Gene

  • Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.

Gene Wiki entry for LRIG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIG1 Gene

Genomics for LRIG1 Gene

Genomic Location for LRIG1 Gene

Start:
66,378,797 bp from pter
End:
66,501,263 bp from pter
Size:
122,467 bases
Orientation:
Minus strand

Genomic View for LRIG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRIG1 Gene

Regulatory Elements for LRIG1 Gene

Proteins for LRIG1 Gene

  • Protein details for LRIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JA1-LRIG1_HUMAN
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 1
    Protein Accession:
    Q96JA1
    Secondary Accessions:
    • Q6IQ51
    • Q96CF9
    • Q9BYB8
    • Q9UFI4

    Protein attributes for LRIG1 Gene

    Size:
    1093 amino acids
    Molecular mass:
    119113 Da
    Quaternary structure:
    • Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.

    Alternative splice isoforms for LRIG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRIG1 Gene

Proteomics data for LRIG1 Gene at MOPED

Post-translational modifications for LRIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys603
  • Glycosylation at Asn74, Asn150, Asn246, Asn292, Asn318, Thr623, and Asn684

Other Protein References for LRIG1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LRIG1 Gene

Domains for LRIG1 Gene

Gene Families for LRIG1 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing

UniProtKB/Swiss-Prot:

LRIG1_HUMAN
Domain:
  • The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted:
    • Q96JA1
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q96JA1
  • Contains 1 LRRCT domain.:
    • Q96JA1
  • Contains 1 LRRNT domain.:
    • Q96JA1
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.:
    • Q96JA1
genes like me logo Genes that share domains with LRIG1: view

Function for LRIG1 Gene

Molecular function for LRIG1 Gene

UniProtKB/Swiss-Prot Function: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
UniProtKB/Swiss-Prot Induction: By EGF.

Gene Ontology (GO) - Molecular Function for LRIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRIG1: view
genes like me logo Genes that share phenotypes with LRIG1: view

Animal Models for LRIG1 Gene

MGI Knock Outs for LRIG1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LRIG1 Gene

Localization for LRIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIG1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRIG1 Gene COMPARTMENTS Subcellular localization image for LRIG1 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LRIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRIG1: view

Pathways for LRIG1 Gene

genes like me logo Genes that share pathways with LRIG1: view

Pathways by source for LRIG1 Gene

1 Sino Biological pathway for LRIG1 Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for LRIG1 Gene
2 Cell Signaling Technology pathways for LRIG1 Gene

Gene Ontology (GO) - Biological Process for LRIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IEA --
GO:0032474 otolith morphogenesis IEA --
GO:0060384 innervation IEA --
genes like me logo Genes that share ontologies with LRIG1: view

Compounds for LRIG1 Gene

(1) Novoseek inferred chemical compound relationships for LRIG1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 12.2 3
genes like me logo Genes that share compounds with LRIG1: view

Transcripts for LRIG1 Gene

Unigene Clusters for LRIG1 Gene

Leucine-rich repeats and immunoglobulin-like domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRIG1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^
SP1: - - - - -
SP2:
SP3: -
SP4: - -
SP5:
SP6:
SP7: -
SP8: - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - - - -
SP11:
SP12:

Relevant External Links for LRIG1 Gene

GeneLoc Exon Structure for
LRIG1
ECgene alternative splicing isoforms for
LRIG1

Expression for LRIG1 Gene

mRNA expression in normal human tissues for LRIG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRIG1 Gene

SOURCE GeneReport for Unigene cluster for LRIG1 Gene Hs.518055

mRNA Expression by UniProt/SwissProt for LRIG1 Gene

Q96JA1-LRIG1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with LRIG1: view

Orthologs for LRIG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRIG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRIG1 36
  • 99.22 (n)
  • 99.22 (a)
LRIG1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRIG1 36
  • 84.28 (n)
  • 84.4 (a)
LRIG1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRIG1 36
  • 85.69 (n)
  • 85.66 (a)
LRIG1 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrig1 36
  • 83.44 (n)
  • 84.03 (a)
Lrig1 16
Lrig1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRIG1 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRIG1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrig1 36
  • 83.07 (n)
  • 83.32 (a)
chicken
(Gallus gallus)
Aves LRIG1 36
  • 72.57 (n)
  • 71.98 (a)
LRIG1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRIG1 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrig1 36
  • 68.43 (n)
  • 70.09 (a)
zebrafish
(Danio rerio)
Actinopterygii lrig1 36
  • 63.2 (n)
  • 63.76 (a)
lrig1 37
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lbk 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sma-10 37
  • 30 (a)
OneToMany
Species with no ortholog for LRIG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRIG1 Gene

ENSEMBL:
Gene Tree for LRIG1 (if available)
TreeFam:
Gene Tree for LRIG1 (if available)

Paralogs for LRIG1 Gene

Paralogs for LRIG1 Gene

Selected SIMAP similar genes for LRIG1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRIG1: view

Variants for LRIG1 Gene

Sequence variations from dbSNP and Humsavar for LRIG1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs332365 -- 66,387,916(+) catgg(G/T)gaaac intron-variant
rs332366 -- 66,387,836(+) ctcac(A/G)cctat intron-variant
rs332367 -- 66,387,532(+) aggaa(A/G)agtca intron-variant
rs332368 -- 66,387,097(+) gaagc(C/T)ctagc intron-variant
rs332369 -- 66,385,534(+) tgcaa(C/T)gtcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRIG1 Gene

Variant ID Type Subtype PubMed ID
nsv516847 CNV Loss 19592680
esv2725369 CNV Deletion 23290073
esv2725370 CNV Deletion 23290073
nsv237304 CNV Loss 16902084
esv2658504 CNV Deletion 23128226
esv23340 CNV Loss 19812545

Relevant External Links for LRIG1 Gene

HapMap Linkage Disequilibrium report
LRIG1

Disorders for LRIG1 Gene

(2) Novoseek inferred disease relationships for LRIG1 Gene

Disease -log(P) Hits PubMed IDs
cancer 10.6 2
tumors 3.56 3

Relevant External Links for LRIG1

Genetic Association Database (GAD)
LRIG1
Human Genome Epidemiology (HuGE) Navigator
LRIG1
genes like me logo Genes that share disorders with LRIG1: view

No data available for UniProtKB/Swiss-Prot for LRIG1 Gene

Publications for LRIG1 Gene

  1. Cloning, characterization, and expression of human LIG1. (PMID: 11414704) Nilsson J. … Hedman H. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Is LRIG1 a tumour suppressor gene at chromosome 3p14.3? (PMID: 12234026) Hedman H. … Henriksson R. (Acta Oncol 2002) 2 3 23
  3. LRIG1 protein in human cells and tissues. (PMID: 12684867) Nilsson J. … Hedman H. (Cell Tissue Res. 2003) 3 23
  4. LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT--PCR and immunohistochemical analysis. (PMID: 14520461) Thomasson M. … Henriksson R. (Br. J. Cancer 2003) 3 23
  5. Increased copy number at 3p14 in breast cancer. (PMID: 16168117) Ljuslinder I. … Henriksson R. (Breast Cancer Res. 2005) 3 23

Products for LRIG1 Gene

  • Addgene plasmids for LRIG1
  • antibodies-online proteins for LRIG1
  • antibodies-online antibodies for LRIG1
  • antibodies-online kits for LRIG1

Sources for LRIG1 Gene

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