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Aliases for LRIG1 Gene

Aliases for LRIG1 Gene

  • Leucine Rich Repeats And Immunoglobulin Like Domains 1 2 3 5
  • Ortholog Of Mouse Integral Membrane Glycoprotein LIG-1 2 3
  • Leucine-Rich Repeat Protein LRIG1 2 3
  • LIG-1 3 4
  • LIG1 3 4
  • Leucine-Rich Repeats And Immunoglobulin-Like Domains Protein 1 3

External Ids for LRIG1 Gene

Previous GeneCards Identifiers for LRIG1 Gene

  • GC03M065048
  • GC03M065899
  • GC03M066259
  • GC03M066362
  • GC03M066511

Summaries for LRIG1 Gene

GeneCards Summary for LRIG1 Gene

LRIG1 (Leucine Rich Repeats And Immunoglobulin Like Domains 1) is a Protein Coding gene. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and MET promotes cell motility. An important paralog of this gene is LRIG3.

UniProtKB/Swiss-Prot for LRIG1 Gene

  • Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.

Gene Wiki entry for LRIG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIG1 Gene

Genomics for LRIG1 Gene

Regulatory Elements for LRIG1 Gene

Enhancers for LRIG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G066448 1.6 Ensembl ENCODE dbSUPER 17.4 +49.6 49571 6.8 HNRNPUL1 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 SP3 SP5 NFYC LRIG1 SLC25A26 DPPA4P1
GH03G066439 1.4 Ensembl ENCODE dbSUPER 18.2 +59.1 59070 4.8 ELF3 PKNOX1 RAD21 YY1 ETS1 ZNF366 GATA2 FOS RELB EGR2 LRIG1 SLC25A26 DPPA4P1
GH03G066471 1.5 Ensembl ENCODE dbSUPER 12.3 +25.8 25773 8.2 PKNOX1 FOXA2 ZFP64 FEZF1 DMAP1 YY1 GATA2 FOS MXD4 JUNB LRIG1 DPPA4P1
GH03G066468 1.4 Ensembl ENCODE dbSUPER 12.1 +32.2 32207 2.1 TBP TBL1XR1 GATA2 CBX5 ZSCAN5C RCOR1 FOS RELB ETV6 IKZF2 LRIG1 DPPA4P1
GH03G066427 1.4 Ensembl ENCODE dbSUPER 11.4 +72.6 72568 2.6 ZFP64 SIN3A FEZF1 ZNF2 RAD21 RFX5 YY1 CBX5 GATA2 ZNF143 LRIG1 SLC25A26 DPPA4P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRIG1 on UCSC Golden Path with GeneCards custom track

Promoters for LRIG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000153962 1263 3201 ARID4B SIN3A DMAP1 SLC30A9 FOS SP3 SP5 NFYC TBX21 MIER3

Genomic Location for LRIG1 Gene

Chromosome:
3
Start:
66,378,797 bp from pter
End:
66,501,263 bp from pter
Size:
122,467 bases
Orientation:
Minus strand

Genomic View for LRIG1 Gene

Genes around LRIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRIG1 Gene

Proteins for LRIG1 Gene

  • Protein details for LRIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JA1-LRIG1_HUMAN
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 1
    Protein Accession:
    Q96JA1
    Secondary Accessions:
    • Q6IQ51
    • Q96CF9
    • Q9BYB8
    • Q9UFI4

    Protein attributes for LRIG1 Gene

    Size:
    1093 amino acids
    Molecular mass:
    119113 Da
    Quaternary structure:
    • Interacts (via extracellular LRR and Ig-like domains) with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 (via extracellular domain) (PubMed:15282549). The physiological relevance of the interaction is controversial; LRIG1 may have low affinity for EGFR, and interaction may occur only when high levels of both proteins are present (PubMed:25765764).

    Three dimensional structures from OCA and Proteopedia for LRIG1 Gene

    Alternative splice isoforms for LRIG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRIG1 Gene

Post-translational modifications for LRIG1 Gene

  • Ubiquitination at posLast=603603
  • Glycosylation at Asn74, Asn150, Asn246, Asn292, posLast=318318, posLast=623623, and posLast=684684
  • Modification sites at PhosphoSitePlus

Other Protein References for LRIG1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LRIG1 (LRIG1)
  • Cloud-Clone Corp. Antibodies for LRIG1
  • Santa Cruz Biotechnology (SCBT) Antibodies for LRIG1

No data available for DME Specific Peptides for LRIG1 Gene

Domains & Families for LRIG1 Gene

Gene Families for LRIG1 Gene

Suggested Antigen Peptide Sequences for LRIG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JA1

UniProtKB/Swiss-Prot:

LRIG1_HUMAN :
  • Contains LRR and Ig-domains that can mediate low-affinity interaction with EGFR (PubMed:25765764). The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when both the LRRs and the Ig-domains are deleted (PubMed:15282549).
Domain:
  • Contains LRR and Ig-domains that can mediate low-affinity interaction with EGFR (PubMed:25765764). The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when both the LRRs and the Ig-domains are deleted (PubMed:15282549).
genes like me logo Genes that share domains with LRIG1: view

Function for LRIG1 Gene

Molecular function for LRIG1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
UniProtKB/Swiss-Prot Induction:
By EGF.
genes like me logo Genes that share phenotypes with LRIG1: view

Animal Models for LRIG1 Gene

MGI Knock Outs for LRIG1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LRIG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRIG1 Gene

Localization for LRIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIG1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRIG1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LRIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRIG1: view

Pathways & Interactions for LRIG1 Gene

genes like me logo Genes that share pathways with LRIG1: view

Pathways by source for LRIG1 Gene

SIGNOR curated interactions for LRIG1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LRIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IEA --
GO:0022405 hair cycle process IEA --
GO:0032474 otolith morphogenesis IEA --
GO:0060384 innervation IEA --
genes like me logo Genes that share ontologies with LRIG1: view

Drugs & Compounds for LRIG1 Gene

(1) Drugs for LRIG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LRIG1: view

Transcripts for LRIG1 Gene

Unigene Clusters for LRIG1 Gene

Leucine-rich repeats and immunoglobulin-like domains 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LRIG1

Alternative Splicing Database (ASD) splice patterns (SP) for LRIG1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^
SP1: - - - - -
SP2:
SP3: -
SP4: - -
SP5:
SP6:
SP7: -
SP8: - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - - - -
SP11:
SP12:

Relevant External Links for LRIG1 Gene

GeneLoc Exon Structure for
LRIG1
ECgene alternative splicing isoforms for
LRIG1

Expression for LRIG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRIG1 Gene

Protein differential expression in normal tissues from HIPED for LRIG1 Gene

This gene is overexpressed in Blymphocyte (56.0) and Plasma (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRIG1 Gene



NURSA nuclear receptor signaling pathways regulating expression of LRIG1 Gene:

LRIG1

SOURCE GeneReport for Unigene cluster for LRIG1 Gene:

Hs.518055

mRNA Expression by UniProt/SwissProt for LRIG1 Gene:

Q96JA1-LRIG1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for LRIG1 Gene

  • Nervous system(4.4)
  • Skin(2.5)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with LRIG1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRIG1 Gene

Orthologs for LRIG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRIG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRIG1 35 34
  • 99.22 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRIG1 34 35
  • 85.69 (n)
cow
(Bos Taurus)
Mammalia LRIG1 35 34
  • 84.28 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrig1 16 35 34
  • 83.44 (n)
rat
(Rattus norvegicus)
Mammalia Lrig1 34
  • 83.07 (n)
oppossum
(Monodelphis domestica)
Mammalia LRIG1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRIG1 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRIG1 35 34
  • 72.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRIG1 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrig1 34
  • 68.43 (n)
zebrafish
(Danio rerio)
Actinopterygii lrig1 35 34
  • 63.2 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lbk 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sma-10 35
  • 30 (a)
OneToMany
Species where no ortholog for LRIG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRIG1 Gene

ENSEMBL:
Gene Tree for LRIG1 (if available)
TreeFam:
Gene Tree for LRIG1 (if available)

Paralogs for LRIG1 Gene

(6) SIMAP similar genes for LRIG1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRIG1: view

Variants for LRIG1 Gene

Sequence variations from dbSNP and Humsavar for LRIG1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000019978 -- 66,378,571(+) AAGGC(A/G)GGATG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000053341 -- 66,436,151(+) CTTGC(A/C)TGGCA intron-variant
rs1000068972 -- 66,444,641(+) CCATC(C/G)CAGAC intron-variant
rs1000071140 -- 66,481,123(+) CTGAG(G/T)TCCCT intron-variant
rs1000083929 -- 66,435,893(+) CTGGG(A/G)GAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRIG1 Gene

Variant ID Type Subtype PubMed ID
dgv8362n54 CNV loss 21841781
dgv8363n54 CNV gain 21841781
esv23340 CNV loss 19812545
esv2658504 CNV deletion 23128226
esv2725369 CNV deletion 23290073
esv2725370 CNV deletion 23290073
esv3596438 CNV loss 21293372
nsv1074599 CNV deletion 25765185
nsv237304 CNV deletion 16902084
nsv478032 CNV novel sequence insertion 20440878
nsv516847 CNV loss 19592680
nsv590546 CNV gain 21841781
nsv590550 CNV loss 21841781
nsv590553 CNV gain+loss 21841781

Variation tolerance for LRIG1 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.94; 94.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRIG1 Gene

Human Gene Mutation Database (HGMD)
LRIG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRIG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRIG1 Gene

Disorders for LRIG1 Gene

Relevant External Links for LRIG1

Genetic Association Database (GAD)
LRIG1
Human Genome Epidemiology (HuGE) Navigator
LRIG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRIG1

No disorders were found for LRIG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRIG1 Gene

Publications for LRIG1 Gene

  1. Cloning, characterization, and expression of human LIG1. (PMID: 11414704) Nilsson J. … Hedman H. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 22 64
  2. Is LRIG1 a tumour suppressor gene at chromosome 3p14.3? (PMID: 12234026) Hedman H. … Henriksson R. (Acta Oncol 2002) 2 3 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PMID: 21076409) Sotoodehnia N. … Arking D.E. (Nat. Genet. 2010) 3 46 64
  5. Increased copy number at 3p14 in breast cancer. (PMID: 16168117) Ljuslinder I. … Henriksson R. (Breast Cancer Res. 2005) 3 22 64

Products for LRIG1 Gene

  • Addgene plasmids for LRIG1

Sources for LRIG1 Gene

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