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LRIF1 Gene

protein-coding   GIFtS: 46
GCID: GC01M111491

Ligand Dependent Nuclear Receptor Interacting Factor 1

(Previous name: chromosome 1 open reading frame 103)
(Previous symbol: C1orf103)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ligand Dependent Nuclear Receptor Interacting Factor 11 2     Receptor-Interacting Factor 12 3
C1orf1031 2 3     Chromosome 1 Open Reading Frame 1031
RIF12 3 5     Ligand-Dependent Nuclear Receptor-Interacting Factor 12
Receptor Interacting Factor 11 2     

External Ids:    HGNC: 302991   Entrez Gene: 557912   Ensembl: ENSG000001219317   OMIM: 6153545   UniProtKB: Q5T3J33   

Export aliases for LRIF1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRIF1 Gene:
LRIF1 (ligand dependent nuclear receptor interacting factor 1) is a protein-coding gene. GO annotations related to this gene include retinoic acid receptor binding.

UniProtKB/Swiss-Prot: LRIF1_HUMAN, Q5T3J3
Function: Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This
repression may occur through direct recruitment of histone deacetylases

Gene Wiki entry for LRIF1 (C1orf103) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for LRIF1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for LRIF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRIF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

LRIF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRIF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M111491:  view genomic region     (about GC identifiers)

Start:
111,489,807 bp from pter      End:
111,506,701 bp from pter
Size:
16,895 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LRIF1_HUMAN, Q5T3J3 (See protein sequence)
Recommended Name: Ligand-dependent nuclear receptor-interacting factor 1  
Size: 769 amino acids; 84568 Da
Subunit: Interacts with RARA
Sequence caution: Sequence=AAH08115.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAO43631.1; Type=Frameshift; Positions=23; Sequence=BAA92097.1; Type=Frameshift; Positions=667;
Secondary accessions: Q86XS4 Q8N3B6 Q96HT4 Q9NUM5 Q9NV32
Alternative splicing: 2 isoforms:  Q5T3J3-1   Q5T3J3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRIF1: NX_Q5T3J3

Explore proteomics data for LRIF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11, Lys134, Lys252, Lys259, Lys279, Lys290, Lys418, Lys427, Lys470, Lys543,
                                 Lys578
  • Modification sites at PhosphoSitePlus

  • See LRIF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006946.1  NP_060842.3  

    ENSEMBL proteins: 
     ENSP00000358778   ENSP00000435259   ENSP00000432290  

    LRIF1 Human Recombinant Protein Products:

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    Novus Biologicals LRIF1 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for LRIF1 (3 products) 

     
    antibodies-online peptides for LRIF1

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    antibodies-online antibodies for LRIF1 (21 products) 

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    antibodies-online kits for LRIF1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026191 LRIF1

    Graphical View of Domain Structure for InterPro Entry Q5T3J3

    ProtoNet protein and cluster: Q5T3J3

    UniProtKB/Swiss-Prot: LRIF1_HUMAN, Q5T3J3
    Similarity: Belongs to the LRIF1 family


    Find genes that share domains with LRIF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRIF1_HUMAN, Q5T3J3
    Function: Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This
    repression may occur through direct recruitment of histone deacetylases

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383276
    GO:0042974retinoic acid receptor binding IEA--
         
    Find genes that share ontologies with LRIF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LRIF1:
     Decreased p24 protein expressi 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LRIF1

    miRNA
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    miRTarBase miRNAs that target LRIF1:
    hsa-mir-155-5p (MIRT020641)

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    3 qRT-PCR Assays for microRNAs that regulate LRIF1:
    hsa-miR-513b hsa-miR-1264 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidLRIF1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRIF1_HUMAN, Q5T3J3: Nucleus matrix

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0015629actin cytoskeleton IDA--
    GO:0016363nuclear matrix IEA--

    Find genes that share ontologies with LRIF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for LRIF1
        Transcriptional Regulatory Network in Embryonic Stem Cell


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRIF1
    Interactions:

        Search GeneGlobe Interaction Network for LRIF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LRIF1 (Q5T3J31, 2, 3 ENSP000003587784) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-64292 MINT-8270915 I2D: score=4 
    SMN2Q166372, 3MINT-64292 MINT-8270915 I2D: score=4 
    CETN3O151822, 3, ENSP000002831224MINT-64362 I2D: score=4 STRING: ENSP00000283122
    TK1P041832, 3MINT-63376 MINT-8273037 I2D: score=4 
    CHD3Q128732, 3, ENSP000003697164MINT-3980693 I2D: score=3 STRING: ENSP00000369716
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with LRIF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRIF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRIF1 gene (2 alternative transcripts): 
    NM_001006945.1  NM_018372.3  

    Unigene Cluster for LRIF1:

    Ligand dependent nuclear receptor interacting factor 1
    Hs.25245  [show with all ESTs]
    Unigene Representative Sequence: NM_018372
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369763(uc001eaa.3 uc001eab.3) ENST00000494675(uc001dzz.3)
    ENST00000485275
    miRNA
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    Block miRNA regulation of human, mouse, rat LRIF1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LRIF1:
    hsa-miR-513b hsa-miR-1264 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidLRIF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LRIF1
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRIF1
      QuantiTect SYBR Green Assays in human, mouse, rat LRIF1
      QuantiFast Probe-based Assays in human, mouse, rat LRIF1

    Additional mRNA sequence: 

    AK001826.1 AK002131.1 AL834466.1 AY190122.1 BC008115.1 

    6 DOTS entries:

    DT.100772197  DT.92037122  DT.75184142  DT.97858791  DT.121382863  DT.95226655 

    Selected AceView cDNA sequences (see all 144):

    AA335643 C04995 BM469792 CR615710 CK902368 AL834466 BU181964 CB988725 
    AA142902 AK001826 BM769098 BC008115 BU192014 BQ787820 CF264904 BG282629 
    AU185993 AU138736 BM989305 AI123216 BU172051 BX089321 BQ787643 AI682290 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LRIF1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for LRIF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRIF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LRIF1 Expression
    About this image

    LRIF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRIF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25245

    UniProtKB/Swiss-Prot: LRIF1_HUMAN, Q5T3J3
    Tissue specificity: Widely expressed, with the highest expression levels in heart, liver and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRIF1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrif11 , 5 RIKEN cDNA 4933421E11 gene5
    ligand dependent nuclear receptor interacting factor more1
    82.93(n)1
    70.78(a)1
      3 (46.52 cM)5
    3210001  NM_001039488.11  NP_001034577.11 
     1066849875 
    chicken
    (Gallus gallus)
    Aves LRIF11 ligand dependent nuclear receptor interacting factor more 58.04(n)
    42.94(a)
      421150  XM_419232.4  XP_419232.3 
    lizard
    (Anolis carolinensis)
    Reptilia LRIF16
    ligand dependent nuclear receptor interacting fact...
    29(a)
    1 ↔ 1
    4(132988966-132998834)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004921921 ligand-dependent nuclear receptor-interacting factor more 52.28(n)
    41.55(a)
      100492192  XM_002941189.2  XP_002941235.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LRIF1 (1 of 2)6
    LRIF1 (2 of 2)6
    ligand dependent nuclear receptor interacting fact...
    ligand dependent nuclear receptor interacting fact...
    18(a)
    18(a)
    many → 1
    many → 1
    8(23106947-23115640) ENSDARG00000069696
    8(23352727-23360943) ENSDARG00000090130


    ENSEMBL Gene Tree for LRIF1 (if available)
    TreeFam Gene Tree for LRIF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRIF1 (see all 472)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1430085791,2
    Cuntested1111492551(+) GAATCA/GAAACC 4 F syn10--------
    rs1892460211,2
    C--111489317(+) TCTGTC/TGCCCA 2 -- ds50010--------
    rs1807234041,2
    --111489318(+) CTGTCA/GCCCAG 2 -- ds50010--------
    rs17126911,2
    C--111489439(+) GTGCCG/CGACTA 2 -- ds50019Minor allele frequency- C:0.00NA WA CSA 16
    rs1427255381,2
    --111489450(+) ATTTTC/TGTATT 2 -- ds50010--------
    rs1842030651,2
    --111489494(+) GGCTTA/GTCTCA 2 -- ds50010--------
    rs1884884201,2
    --111489512(+) GACCTC/TAGGTG 2 -- ds50010--------
    rs1812676691,2
    --111489522(+) GATCCA/GCCCGC 2 -- ds50010--------
    rs1449916411,2
    --111489575(+) CACCCA/GGCCTG 2 -- ds50010--------
    rs1388516751,2
    --111489611(+) CTCCTC/TCTCCT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for LRIF1 (111489807 - 111506701 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LRIF1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRIF1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRIF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615354    OMIM disorders: --


    Find genes that share disorders with LRIF1           About GenesLikeMe


    Export disorders for LRIF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRIF1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with LRIF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix. (PubMed id 17455211)1, 2, 3 Li H.J.... Mendelsohn M. (J. Cell. Biochem. 2007)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway. (PubMed id 23542155)1 Nozawa R.S....Obuse C. (amp 2013)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55791 HGNC: 30299 AceView: RIF1 Ensembl:ENSG00000121931 euGenes: HUgn55791
    ECgene: LRIF1 H-InvDB: LRIF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRIF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRIF1 gene:
    Search GeneIP for patents involving LRIF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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