LRIF1 Gene
protein-coding GIFtS: 45
GCID: GC01M111491
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ligand dependent nuclear receptor interacting factor 1(Previous name: chromosome 1 open reading frame 103 )
(Previous symbol: C1orf103)
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Aliases
for LRIF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ligand Dependent Nuclear Receptor Interacting Factor 11 2 | | Chromosome 1 Open Reading Frame 1031 | | C1orf1031 2 3 | | RP11-96K19.12 | | RIF11 2 3 | | Ligand-Dependent Nuclear Receptor-Interacting Factor 12 | | Receptor-Interacting Factor 12 3 | | Receptor Interacting Factor 12 | | FLJ112691 | | |
Export aliases for LRIF1 gene to outside databases |
Summaries
for LRIF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LRIF1_HUMAN, Q5T3J3Function: Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This repressionmay occur through direct recruitment of histone deacetylases
Gene Wiki entry for LRIF1 (C1orf103)
|
Genomic Views
for LRIF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for LRIF1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRIF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRIF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3LRIF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M111491: view genomic region
(about GC identifiers)
Start:
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111,489,807 bp from pter |
End:
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111,506,701 bp from pter |
Size:
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16,895 bases |
Orientation:
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minus strand |
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Proteins
for LRIF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRIF1_HUMAN, Q5T3J3 (See
protein sequence)Recommended Name: Ligand-dependent nuclear receptor-interacting factor 1 Size: 769 amino acids; 84568 Da
Subunit: Interacts with RARA
Subcellular location: Nucleus matrix
Sequence caution: Sequence=AAH08115.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAO43631.1; Type=Frameshift; Positions=23; Sequence=BAA92097.1; Type=Frameshift; Positions=667;
Secondary accessions: Q86XS4 Q8N3B6 Q96HT4 Q9NUM5 Q9NV32Alternative splicing: 2 isoforms: Q5T3J3-1 Q5T3J3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for LRIF1: NX_Q5T3J3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T3J3
LRIF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001006946.1 NP_060842.3
ENSEMBL proteins: ENSP00000358778 ENSP00000435259 ENSP00000432290
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
LRIF1 for ontologies About GeneDecksing
LRIF1 Antibody Products:
Assay Products for LRIF1: |
Protein
Domains /
Families
for LRIF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRIF1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T3J3ProtoNet protein and cluster: Q5T3J3 UniProtKB/Swiss-Prot: LRIF1_HUMAN, Q5T3J3Similarity: Belongs to the LRIF1 family |
Function
for LRIF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LRIF1_HUMAN, Q5T3J3Function: Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This repressionmay occur through direct recruitment of histone deacetylases
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRIF1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRIF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for LRIF1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRIF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIF1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
LRIF1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for LRIF1:
|
Pathways & Interactions
for LRIF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRIF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/182 Interacting proteins for LRIF1 (Q5T3J31, 2, 3 ENSP000003587784) via UniProtKB, MINT, STRING, and/or I2D (see all 182)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
LRIF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for LRIF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRIF1
Search CenterWatch for drugs/clinical trials and news about LRIF1
|
Transcripts
for LRIF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRIF1 gene (2 alternative transcripts): NM_001006945.1 NM_018372.3 Unigene Cluster for LRIF1: Ligand dependent nuclear receptor interacting factor 1 Hs.25245 [show with all ESTs]Unigene Representative Sequence: NM_0183723 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369763(uc001eaa.3 uc001eab.3) ENST00000494675(uc001dzz.3)
ENST00000485275
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRIF1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRIF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for LRIF1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRIF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIF1 |
Additional cDNA sequence: AK001826.1 AK002131.1 AL834466.1 AY190122.1 BC008115.1 6 DOTS entries: DT.100772197 DT.92037122 DT.75184142 DT.97858791 DT.121382863 DT.95226655 24/144 AceView cDNA sequences (see all 144): BU172051 BM989305 AU138736 AK001826 AW957450 BQ787643 BX089321 BU181964 CB988725 CR620638 CK902368 BM456124 BQ787820 AI682290 CR615710 BG282629 AW451750 AI123216 BU192014 AU185993 C04995 BM769098 AA142902 AL834466
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for LRIF1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 |
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| SP1: | | | | | - | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for LRIF1
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Expression
for LRIF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRIF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LRIF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRIF1
SOURCE GeneReport for Unigene cluster: Hs.25245
UniProtKB/Swiss-Prot: LRIF1_HUMAN, Q5T3J3Tissue specificity: Widely expressed, with the highest expression levels in heart, liver and placenta
SABiosciences Custom PCR Arrays for LRIF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRIF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRIF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRIF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRIF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIF1 |
Orthologs
for LRIF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for LRIF1 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for LRIF1 (if available)
TreeFam Gene Tree for LRIF1 (if available) |
Paralogs
for LRIF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for LRIF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRIF1 (111489807 - 111506701 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LRIF1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRIF1 |
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Disorders
/ Diseases
for LRIF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LRIF1 for disorders About GeneDecksing
1  disease for LRIF1: About MalaCardshuntington's disease
Export disorders for LRIF1 gene to outside databases
|
Publications
for LRIF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRIF1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with LRIF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix. (PubMed id 17455211)1, 2, 3 Li H.J....Mendelsohn M. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for LRIF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing LRIF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRIF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LRIF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRIF1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for LRIF1 gene:
Search GeneIP for patents involving LRIF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRIF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LRIF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRIF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRIF1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LRIF1 | | OriGene 3'-UTR Clone for LRIF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRIF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRIF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LRIF1 | | OriGene Custom Protein Services for LRIF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRIF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRIF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRIF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRIF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRIF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRIF1 |
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| | | | Search Tocris compounds for LRIF1 |
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 | | | LRIF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIF1 |
|  |  |  | | | | ThermoFisher Antibodies for LRIF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIF1 |
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