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LRGUK Gene

protein-coding   GIFtS: 49
GCID: GC07P133812

Leucine-Rich Repeats And Guanylate Kinase Domain Containing

  Search for LRGUK
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine-Rich Repeats And Guanylate Kinase Domain Containing1 2
Leucine-Rich Repeat And Guanylate Kinase Domain-Containing Protein2

External Ids:    HGNC: 219641   Entrez Gene: 1363322   Ensembl: ENSG000001555307   UniProtKB: Q96M693   

Export aliases for LRGUK gene to outside databases

Previous GC identifers: GC07P133463 GC07P128113


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRGUK Gene:
LRGUK (leucine-rich repeats and guanylate kinase domain containing) is a protein-coding gene. GO annotations related to this gene include kinase activity. An important paralog of this gene is LRRC23.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRGUK gene promoter:
         HNF-3beta   E4BP4   RORalpha1   AREB6   S8   FAC1   FOXJ2 (long isoform)   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LRGUK promoter sequence
   Search Chromatin IP Primers for LRGUK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRGUK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

LRGUK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRGUK gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P133812:  view genomic region     (about GC identifiers)

Start:
133,812,052 bp from pter      End:
133,949,343 bp from pter
Size:
137,292 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 133,156,684-133,293,312     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRGUK_HUMAN, Q96M69 (See protein sequence)
Recommended Name: Leucine-rich repeat and guanylate kinase domain-containing protein  
Size: 825 amino acids; 93618 Da
Secondary accessions: Q2M3I1

Explore the universe of human proteins at neXtProt for LRGUK: NX_Q96M69

Explore proteomics data for LRGUK at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LRGUK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653249.1  
    ENSEMBL proteins: 
     ENSP00000285928  

    LRGUK Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for LRGUK

     
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    Cloud-Clone Corp. ELISAs for LRGUK
    Cloud-Clone Corp. CLIAs for LRGUK
    Search eBioscience for ELISAs for LRGUK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR008144 Guanylate_kin-like
     IPR008145 GK/Ca_channel_bsu
     IPR001611 Leu-rich_rpt
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q96M69

    ProtoNet protein and cluster: Q96M69

    1 Blocks protein domain: IPB008144 Guanylate kinase

    UniProtKB/Swiss-Prot: LRGUK_HUMAN, Q96M69
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 9 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    Find genes that share domains with LRGUK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity IEA--
         
    Find genes that share ontologies with LRGUK           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LRGUK:
     Increased cell number in G1, s 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRGUK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRGUK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRGUK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRGUK

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidLRGUK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRGUK
    Predesigned siRNA for gene silencing in human, mouse, rat LRGUK

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LRGUK

    Clone
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    GenScript: all cDNA clones in your preferred vector: LRGUK (NM_144648)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRGUK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRGUK
    Addgene plasmids for LRGUK 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRGUK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with LRGUK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRGUK
    Interactions:

        Search GeneGlobe Interaction Network for LRGUK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for LRGUK (ENSP000002859284) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPAA1ENSP000003472064STRING: ENSP00000347206
    VPS53ENSP000004014354STRING: ENSP00000401435
    FAF1ENSP000003794574STRING: ENSP00000379457
    FAF2ENSP000002619424STRING: ENSP00000261942
    IMPAD1ENSP000002626444STRING: ENSP00000262644
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRGUK



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRGUK gene: 
    NM_144648.1  

    Unigene Cluster for LRGUK:

    Leucine-rich repeats and guanylate kinase domain containing
    Hs.149774  [show with all ESTs]
    Unigene Representative Sequence: AK057348
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285928(uc003vrm.1) ENST00000473068
    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate LRGUK
    SwitchGear 3'UTR luciferase reporter plasmidLRGUK 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat LRGUK
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    OriGene ORF clones in mouse, rat for LRGUK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRGUK (NM_144648)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRGUK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRGUK
    Addgene plasmids for LRGUK 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRGUK
      QuantiTect SYBR Green Assays in human, mouse, rat LRGUK
      QuantiFast Probe-based Assays in human, mouse, rat LRGUK

    Additional mRNA sequence: 

    AK057348.1 BC038800.1 BC104897.1 BC104899.1 

    4 DOTS entries:

    DT.100810978  DT.97802635  DT.97768093  DT.97790354 

    17 AceView cDNA sequences:

    AK057348 NM_144648 BM450065 AL698215 AI453518 BC038800 AI285997 BP361407 
    CB242561 BE044261 BM979173 AA383631 CA310740 CA314021 CA944734 BG183144 
    BG185894 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRGUK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTCCAGCTG
    LRGUK Expression
    About this image


    LRGUK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Testis (Reproductive System)
    LRGUK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRGUK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149774
        Custom PCR Arrays for LRGUK
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRGUK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for LRGUK gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrguk1 , 5 leucine-rich repeats and guanylate kinase domain containing1, 5 78.12(n)1
    73.72(a)1
      6 (14.75 cM)5
    743541  NM_028886.11  NP_083162.11 
     340294485 
    chicken
    (Gallus gallus)
    Aves LRGUK1 leucine-rich repeats and guanylate kinase domain containing 64.02(n)
    58.08(a)
      416699  XM_414995.4  XP_414995.3 
    lizard
    (Anolis carolinensis)
    Reptilia LRGUK6
    leucine-rich repeats and guanylate kinase domain c...
    48(a)
    1 ↔ 1
    5(3360839-3460148)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrguk1 leucine-rich repeats and guanylate kinase domain containing 60.65(n)
    56.67(a)
      100492151  XM_002931868.2  XP_002931914.2 
    zebrafish
    (Danio rerio)
    Actinopterygii lrguk1 leucine-rich repeats and guanylate kinase domain containing 54.49(n)
    49.36(a)
      559670  XM_005164710.1  XP_005164767.1 
    worm
    (Caenorhabditis elegans)
    Secernentea magu-36
    Protein MAGU-3 (magu-3) mRNA, complete cds
    13(a)
    1 → many
    I(3901432-3905200) WBGene00016841
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NUD1(YOR373W)4 Component of the spindle pole body outer plaque, required more   --   15(1036834-1039389) 854555  NP_015018.1 


    ENSEMBL Gene Tree for LRGUK (if available)
    TreeFam Gene Tree for LRGUK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRGUK gene
    LRRC232  GUK12  

    Find genes that share paralogs with LRGUK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRGUK (see all 2708)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425465081,2
    --133154703(+) GCTCAA/GTGTTC 1 -- us2k10--------
    rs1509641351,2
    --133154928(+) TAGAAA/TCTTTC 1 -- us2k10--------
    rs1831598011,2
    --133154931(+) AATCTG/TTCACA 1 -- us2k10--------
    rs4079281,2
    C,F,A,H--133155067(-) TTTCAA/GTAACT 1 -- us2k116Minor allele frequency- G:0.05NS EA NA WA CSA 794
    rs1121829141,2
    C,F--133155106(+) GCGGGC/TGGATC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1880448571,2
    C--133155126(+) GGAGAG/TCGAGA 1 -- us2k10--------
    rs3777337721,2
    C--133155147(+) TAACAC/TGTGAA 1 -- us2k10--------
    rs3757399561,2
    C--133155197(+) GTGGTA/GCGGGC 1 -- us2k10--------
    rs3706806171,2
    C--133155224(+) TACTCA/GGAGGC 1 -- us2k10--------
    rs3688911,2
    C--133155296(-) tggagG/Tgcagt 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LRGUK (133812052 - 133949343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LRGUK (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735177CNV Deletion23290073
    esv2677377CNV Deletion23128226
    esv2735178CNV Deletion23290073
    esv2735179CNV Deletion23290073
    esv267899CNV Insertion20981092
    nsv507421CNV Insertion20534489
    nsv5957CNV Loss18451855
    nsv508483CNV Loss20534489
    nsv521054CNV Loss19592680
    nsv889216CNV Gain21882294

    Human Gene Mutation Database (HGMD): LRGUK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRGUK
    DNA2.0 Custom Variant and Variant Library Synthesis for LRGUK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with LRGUK           About GenesLikeMe

    Genetic Association Database (GAD): LRGUK
    Human Genome Epidemiology (HuGE) Navigator: LRGUK (2 documents)

    Export disorders for LRGUK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRGUK gene integrated from 10 sources:
    (articles sorted by number of sources associating them with LRGUK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. (PubMed id 18498660)1, 4 Laramie J.M....Myers R.H. (BMC Med. Genet. 2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    6. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)4 O'Donnell C.J....Demissie S. (BMC Med. Genet. 2007)
    7. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    8. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 136332 HGNC: 21964 AceView: FLJ32786 Ensembl:ENSG00000155530 euGenes: HUgn136332
    ECgene: LRGUK H-InvDB: LRGUK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRGUK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRGUK gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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