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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LRGUK Gene

protein-coding GIFtS: 46
GCID: GC07P133812

leucine-rich repeats and guanylate kinase domain containing

Search for LRGUK
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leucine-Rich Repeats And Guanylate Kinase Domain Containing¹ ²
FLJ32786¹
Leucine-Rich Repeat And Guanylate Kinase Domain-Containing Protein²

External Ids:	HGNC: 21964¹	Entrez Gene: 136332²	Ensembl: ENSG00000155530⁷	UniProtKB: Q96M69³

Export aliases for LRGUK gene to outside databases

Previous GC identifers: GC07P133463 GC07P128113

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LRGUK gene promoter:
HNF-3beta E4BP4 RORalpha1 AREB6 S8 FAC1 FOXJ2 (long isoform) FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LRGUK promoter sequence

Search SABiosciences Chromatin IP Primers for LRGUK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRGUK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33

LRGUK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRGUK gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P133812: view genomic region (about GC identifiers)

Start:	133,812,052 bp from pter	End:	133,949,343 bp from pter
Size:	137,292 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 133,156,684-133,293,312

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LRGUK_HUMAN, Q96M69 (See protein sequence)

Recommended Name: Leucine-rich repeat and guanylate kinase domain-containing protein

Size: 825 amino acids; 93618 Da

Secondary accessions: Q2M3I1

Explore the universe of human proteins at neXtProt for LRGUK: NX_Q96M69

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96M69

LRGUK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653249.1

ENSEMBL proteins:

ENSP00000285928

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LRGUK for domains About GeneDecksing

4 InterPro domains/families:

IPR008144 Guanylate_kin

IPR008145 Guanylate_kin/L-typ_Ca_channel

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

Graphical View of Domain Structure for InterPro Entry Q96M69

ProtoNet protein and cluster: Q96M69

1 Blocks protein family: IPB008144 Guanylate kinase

UniProtKB/Swiss-Prot: LRGUK_HUMAN, Q96M69

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 9 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005524	ATP binding	IEA	--
GO:0016301	kinase activity	IEA	--

LRGUK for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for LRGUK:

Increased cell number in G1, s

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LRGUK

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LRGUK
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for LRGUK gene:

NM_144648.1

Unigene Cluster for LRGUK:

Leucine-rich repeats and guanylate kinase domain containing

Hs.149774 [show with all ESTs]

Unigene Representative Sequence: AK057348

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000285928(uc003vrm.1) ENST00000473068

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Additional cDNA sequence:

AK057348.1 BC038800.1 BC104897.1 BC104899.1

4 DOTS entries:

DT.100810978 DT.97802635 DT.97768093 DT.97790354

17 AceView cDNA sequences:

AK057348 NM_144648 AL698215 BM450065 AI453518 AI285997 BP361407 BC038800

CB242561 AA383631 BE044261 BM979173 CA314021 CA310740 BG183144 CA944734

BG185894

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LRGUK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTCCAGCTG

About this image

LRGUK expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Intermediate Mesoderm

Intermediate Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See LRGUK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRGUK

SOURCE GeneReport for Unigene cluster: Hs.149774

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LRGUK gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LRGUK¹	leucine-rich repeats and guanylate kinase domain containing	63.82(n) 57.93(a)		416699 XM_414995.3 XP_414995.3
lizard (Anolis carolinensis)	Reptilia	LRGUK⁶	--	61(a)	1 ↔ 1	5(3377421-3434745)
zebrafish (Danio rerio)	Actinopterygii	lrguk¹	leucine-rich repeats and guanylate kinase domain containing	54.4(n) 49.36(a)		559670 NM_001123247.1 NP_001116719.1
honey bee (Apis mellifera)	Insecta	-- --	--	8(a) 14(a)	possible ortholog 1 ↔ 1	GroupUn.824(122-1706) GroupUn.30(129586-133386)
worm (Caenorhabditis elegans)	Secernentea	T05H4.3⁶	Protein T05H4.3	5(a)	1 ↔ 1	V(6442320-6447539)

ENSEMBL Gene Tree for LRGUK (if available)
TreeFam Gene Tree for LRGUK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LRGUK gene

LRRC48² PPP1R7² DNAAF1² PPP1R42² LRRC9² LRRC23² LRRC49²

LRGUK for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112182914^1,2	C,	--	133155106(+)	`GCGGGC/TGGATC`	1	--	us2k¹		1		WA	2
rs368891^1,2	C,	--	133155296(-)	`tggagG/Tgcagt`	1	--	us2k¹		0	--	--	--	--
rs78368905^1,2	C,	--	133155597(+)	`CAGTTT/GTAACG`	1	--	us2k¹		2		CSA WA	120
rs111717441^1,2		--	133155630(+)	`TAATCG/CTCAAT`	1	--	us2k¹		1		CSA	2
rs73454621^1,2	C,F,	--	133156027(+)	`TAGCTT/GTTCAG`	1	--	us2k¹		3		WA CSA	122
rs78230216^1,2		--	133157440(+)	`CTCCAG/AGAAAA`	1	--	int¹		1		NA	2
rs73454622^1,2	C,F,	--	133157703(+)	`TCTACA/GATATC`	1	--	int¹		3		WA CSA	122
rs73454623^1,2	C,F,	--	133157754(+)	`ATTATG/CGTCCT`	1	--	int¹		5		WA CSA	125
rs113162853^1,2		--	133158020(+)	`GGACTG/ACAGGT`	1	--	int¹		1		CSA	1
rs112730643^1,2		--	133158089(+)	`GTTAGC/TCAGGA`	1	--	int¹		2		CSA	3

HapMap Linkage Disequilibrium report for LRGUK (133812052 - 133949343 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for LRGUK
2 CNVs: 36620 3704

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LRGUK for disorders About MalaCards

LRGUK for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: LRGUK (2 documents)

Export disorders for LRGUK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LRGUK gene integrated from 9 sources:
(articles sorted by number of sources associating them with LRGUK)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. (PubMed id 18498660)¹ Laramie J.M....Myers R.H. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 136332	HGNC: 21964	AceView: FLJ32786	Ensembl:ENSG00000155530	euGenes: HUgn136332
ECgene: LRGUK	H-InvDB: LRGUK

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LRGUK	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LRGUK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LRGUK gene:
Search GeneIP for patents involving LRGUK

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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Browse ProSpec Recombinant Proteins

LRGUK Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for LRGUK

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRGUK

	SwitchGear 3'UTR luciferase reporter plasmids for LRGUK
	SwitchGear Promoter luciferase reporter plasmids for LRGUK

ThermoFisher Antibodies for LRGUK

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRGUK

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LRGUK gene at Home site.

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LRGUK Gene

leucine-rich repeats and guanylate kinase domain containing

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Export list of displayed genes

LRGUK Gene

leucine-rich repeats and guanylate kinase domain containing

Aliasesfor LRGUK gene

Summariesfor LRGUK gene

Genomic Viewsfor LRGUK gene

Proteinsfor LRGUK gene

Protein Domains /Familiesfor LRGUK gene

Functionfor LRGUK gene

Pathways & Interactionsfor LRGUK gene

Drugs & Compoundsfor LRGUK gene

Transcriptsfor LRGUK gene

Expression for LRGUK gene

Orthologsfor LRGUK gene

Paralogsfor LRGUK gene

Genomic Variantsfor LRGUK gene

Disorders / Diseasesfor LRGUK gene

Publicationsfor LRGUK gene

External Searches for LRGUK gene

Genome Databases showing LRGUK gene

Other Databases showing LRGUK gene

Specialized Databases showing LRGUK gene

Intellectual Propertyfor LRGUK gene

Productsfor LRGUK gene

View Random Gene

Aliases
for LRGUK gene

Summaries
for LRGUK gene

Genomic Views
for LRGUK gene

Proteins
for LRGUK gene

Protein Domains /
Families
for LRGUK gene

Function
for LRGUK gene

Pathways & Interactions
for LRGUK gene

Drugs & Compounds
for LRGUK gene

Transcripts
for LRGUK gene

Expression
for LRGUK gene

Orthologs
for LRGUK gene

Paralogs
for LRGUK gene

Genomic Variants
for LRGUK gene

Disorders / Diseases
for LRGUK gene

Publications
for LRGUK gene

Intellectual Property
for LRGUK gene

Products
for LRGUK gene