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Aliases for LRG1 Gene

Aliases for LRG1 Gene

  • Leucine Rich Alpha-2-Glycoprotein 1 2 3 5
  • Leucine Rich Alpha 2 Glycoprotein 2 3
  • LRG 3 4
  • Leucine-Rich Alpha-2-Glycoprotein 3
  • 1300008B03Rik 3
  • 2310031E04Rik 3
  • HMFT1766 3

External Ids for LRG1 Gene

Previous GeneCards Identifiers for LRG1 Gene

  • GC00U914351
  • GC19M004488
  • GC19M004489
  • GC19M004298

Summaries for LRG1 Gene

Entrez Gene Summary for LRG1 Gene

  • The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LRG1 Gene

LRG1 (Leucine Rich Alpha-2-Glycoprotein 1) is a Protein Coding gene. Diseases associated with LRG1 include Appendicitis and Dependent Personality Disorder. Among its related pathways are Immune System. GO annotations related to this gene include transforming growth factor beta receptor binding. An important paralog of this gene is CPN2.

Gene Wiki entry for LRG1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRG1 Gene

Genomics for LRG1 Gene

Regulatory Elements for LRG1 Gene

Enhancers for LRG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F004539 1.2 FANTOM5 ENCODE 9.4 0.0 -10 2.8 HDGF ATF1 MLX SIN3A ARID4B DMAP1 YY1 SP5 GTF2B NFYC SH3GL1 ENSG00000267255 PLIN5 LRG1 KDM4B TICAM1 SEMA6B ZBTB7A CCDC94 GC19P004547
GH19F005176 0.9 Ensembl ENCODE 5.7 -636.5 -636521 1.8 BCOR ZNF146 ZMYM3 JUNB CEBPB CEBPG GTF3C2 ZNF121 ZNF512 IKZF1 DPP9-AS1 ENSG00000267030 ENSG00000267769 SH3GL1 ENSG00000267571 VMAC SNRPEP4 SAFB PLIN3 ENSG00000267255
GH19F004152 1.3 Ensembl ENCODE 5.5 +386.6 386636 2.6 ATF1 PKNOX1 YY1 ZNF121 GATA2 FOS SP5 NFYC PPARG ZNF623 LRG1 MYDGF CREB3L3 GC19M004146
GH19F004142 0.5 Ensembl ENCODE 4.7 +393.9 393901 8.0 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 CACTIN ANKRD24 SIRT6 MAP2K2 FZR1 ENSG00000267030 FSD1 TMIGD2 ENSG00000267769 ENSG00000269318
GH19F004981 0.5 Ensembl 4.4 -440.9 -440927 0.4 GLIS1 EBF1 ZIC2 LRG1 GC19M004987 PIR49056
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRG1 on UCSC Golden Path with GeneCards custom track

Promoters for LRG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001815453 374 601 HDGF ATF1 MLX SIN3A ARID4B DMAP1 YY1 SP5 GTF2B NFYC

Genomic Location for LRG1 Gene

Chromosome:
19
Start:
4,536,409 bp from pter
End:
4,540,474 bp from pter
Size:
4,066 bases
Orientation:
Minus strand

Genomic View for LRG1 Gene

Genes around LRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRG1 Gene

Proteins for LRG1 Gene

  • Protein details for LRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02750-A2GL_HUMAN
    Recommended name:
    Leucine-rich alpha-2-glycoprotein
    Protein Accession:
    P02750
    Secondary Accessions:
    • Q8N4F5
    • Q96QZ4

    Protein attributes for LRG1 Gene

    Size:
    347 amino acids
    Molecular mass:
    38178 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRG1 Gene

Post-translational modifications for LRG1 Gene

  • Glycosylation at Thr 37, Asn 79, Asn 186, Asn 269, and Asn 325
  • Modification sites at PhosphoSitePlus

Other Protein References for LRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRG1 Gene

Domains & Families for LRG1 Gene

Graphical View of Domain Structure for InterPro Entry

P02750

UniProtKB/Swiss-Prot:

A2GL_HUMAN :
  • Contains 1 LRRCT domain.
  • Contains 8 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRG1: view

No data available for Gene Families for LRG1 Gene

Function for LRG1 Gene

Gene Ontology (GO) - Molecular Function for LRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005160 transforming growth factor beta receptor binding IEA --
genes like me logo Genes that share ontologies with LRG1: view

Phenotypes for LRG1 Gene

genes like me logo Genes that share phenotypes with LRG1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRG1 Gene

Localization for LRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRG1 Gene COMPARTMENTS Subcellular localization image for LRG1 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
golgi apparatus 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 12223515
GO:0005615 extracellular space IEA,IDA 16502470
GO:0016020 membrane NAS 3856868
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LRG1: view

Pathways & Interactions for LRG1 Gene

SuperPathways for LRG1 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with LRG1: view

Pathways by source for LRG1 Gene

2 Reactome pathways for LRG1 Gene

Gene Ontology (GO) - Biological Process for LRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0008150 biological_process ND --
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0045766 positive regulation of angiogenesis IEA --
GO:0050873 brown fat cell differentiation IEA --
genes like me logo Genes that share ontologies with LRG1: view

No data available for SIGNOR curated interactions for LRG1 Gene

Transcripts for LRG1 Gene

mRNA/cDNA for LRG1 Gene

Unigene Clusters for LRG1 Gene

Leucine-rich alpha-2-glycoprotein 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRG1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e
SP1: - -
SP2: -
SP3: - -

Relevant External Links for LRG1 Gene

GeneLoc Exon Structure for
LRG1
ECgene alternative splicing isoforms for
LRG1

Expression for LRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRG1 Gene

This gene is overexpressed in Liver (x35.3) and Whole Blood (x11.8).

Protein differential expression in normal tissues from HIPED for LRG1 Gene

This gene is overexpressed in Urine (19.2), Synovial fluid (11.4), Serum (6.7), and Plasma (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRG1 Gene



Protein tissue co-expression partners for LRG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRG1 Gene:

LRG1

SOURCE GeneReport for Unigene cluster for LRG1 Gene:

Hs.655559

mRNA Expression by UniProt/SwissProt for LRG1 Gene:

P02750-A2GL_HUMAN
Tissue specificity: Plasma.
genes like me logo Genes that share expression patterns with LRG1: view

Primer Products

Orthologs for LRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRG1 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia LRG1 34 35
  • 78.96 (n)
cow
(Bos Taurus)
Mammalia LRG1 34 35
  • 76.88 (n)
mouse
(Mus musculus)
Mammalia Lrg1 34 16 35
  • 69.35 (n)
rat
(Rattus norvegicus)
Mammalia Lrg1 34
  • 67.65 (n)
oppossum
(Monodelphis domestica)
Mammalia LRG1 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858066 34
  • 52.45 (n)
LRG1 35
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRG1 35
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrg1 34
  • 44.09 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-90m5.4 34
  • 45.69 (n)
LRG1 35
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16974 35
  • 8 (a)
OneToMany
Species where no ortholog for LRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRG1 Gene

ENSEMBL:
Gene Tree for LRG1 (if available)
TreeFam:
Gene Tree for LRG1 (if available)

Paralogs for LRG1 Gene

(2) SIMAP similar genes for LRG1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for LRG1 Gene

genes like me logo Genes that share paralogs with LRG1: view

Variants for LRG1 Gene

Sequence variations from dbSNP and Humsavar for LRG1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401592 -- 4,539,806(+) TTCTG(C/T)AGGGG intron-variant
rs10404783 -- 4,537,001(+) ACACC(C/T)GGGCA downstream-variant-500B, upstream-variant-2KB
rs10406111 -- 4,537,266(+) AGCTA(A/C)GTGGG utr-variant-3-prime
rs10412220 -- 4,538,714(+) GAGGC(A/G)CCCTG reference, synonymous-codon
rs10419830 -- 4,539,167(+) CTGTT(C/G)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRG1 Gene

Variant ID Type Subtype PubMed ID
nsv428361 CNV loss 18775914
nsv578444 CNV gain 21841781
nsv833720 CNV loss 17160897

Variation tolerance for LRG1 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.47; 77.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRG1 Gene

Disorders for LRG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
appendicitis
  • acute appendicitis
dependent personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search LRG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LRG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRG1
genes like me logo Genes that share disorders with LRG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRG1 Gene

Publications for LRG1 Gene

  1. Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation. (PMID: 12223515) O'Donnell L.C. … Avalos B.R. (J. Leukoc. Biol. 2002) 2 3 4 64
  2. Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. (PMID: 3856868) Takahashi N. … Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4 64
  3. Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1. (PMID: 19851871) Codina R. … Jemmerson R. (Apoptosis 2010) 3 22 64
  4. Specific isoforms of leucine-rich alpha2-glycoprotein detected in the proliferative endometrium of women undergoing assisted reproduction are associated with spontaneous pregnancy. (PMID: 17583700) Gillott D.J. … Grudzinskas J.G. (Fertil. Steril. 2008) 3 22 64
  5. Expression of TGF-betas and TGF-beta type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus. (PMID: 17194537) Li X. … Arai H. (Neurosci. Lett. 2007) 3 22 64

Products for LRG1 Gene

Sources for LRG1 Gene

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