Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LRFN1 Gene

Aliases for LRFN1 Gene

  • Leucine Rich Repeat And Fibronectin Type III Domain Containing 1 2 3
  • SALM2 3 4 6
  • Synaptic Adhesion-Like Molecule 2 3 4
  • KIAA1484 4 6
  • Leucine-Rich Repeat And Fibronectin Type III Domain-Containing Protein 1 3
  • CTC-246B18.8 3

External Ids for LRFN1 Gene

Summaries for LRFN1 Gene

GeneCards Summary for LRFN1 Gene

LRFN1 (Leucine Rich Repeat And Fibronectin Type III Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is LINGO1.

UniProtKB/Swiss-Prot for LRFN1 Gene

  • Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRFN1 Gene

Genomics for LRFN1 Gene

Genomic Location for LRFN1 Gene

39,306,568 bp from pter
39,316,116 bp from pter
9,549 bases
Minus strand

Genomic View for LRFN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRFN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRFN1 Gene

Regulatory Elements for LRFN1 Gene

Proteins for LRFN1 Gene

  • Protein details for LRFN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat and fibronectin type III domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8TBS9

    Protein attributes for LRFN1 Gene

    771 amino acids
    Molecular mass:
    82318 Da
    Quaternary structure:
    • Can form heteromeric complexes with LRFN2, LRFN3, LRFN4 and LRFN5 (By similarity). Forms homomeric complexes, but not across cell junctions (By similarity). Interacts with DLG1, DLG2, DLG3 and DLG4. Interacts with 2 AMPA receptor subunits GRIA1 and GRIA2 and NMDA receptor subunit GRIN1 (By similarity).

neXtProt entry for LRFN1 Gene

Proteomics data for LRFN1 Gene at MOPED

Post-translational modifications for LRFN1 Gene

Other Protein References for LRFN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRFN1 Gene

Domains for LRFN1 Gene

Gene Families for LRFN1 Gene

  • ISET :Immunoglobulin superfamily / I-set domain containing
  • FN3 :Fibronectin type III domain containing


  • The PDZ-binding motif is required for neurite outgrowth promotion and for DLG1-, DLG3- and DLG4-binding.:
    • Q9P244
  • Contains 1 fibronectin type-III domain.:
    • Q9P244
  • Contains 1 Ig-like (immunoglobulin-like) domain.:
    • Q9P244
  • Contains 1 LRRCT domain.:
    • Q9P244
  • Contains 1 LRRNT domain.:
    • Q9P244
  • Belongs to the LRFN family.:
    • Q9P244
  • Contains 7 LRR (leucine-rich) repeats.:
    • Q9P244
genes like me logo Genes that share domains with LRFN1: view

Function for LRFN1 Gene

Molecular function for LRFN1 Gene

UniProtKB/Swiss-Prot Function: Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity).

Gene Ontology (GO) - Molecular Function for LRFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRFN1: view

miRNA for LRFN1 Gene

miRTarBase miRNAs that target LRFN1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LRFN1 Gene

Localization for LRFN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRFN1 Gene

Membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for LRFN1 Gene COMPARTMENTS Subcellular localization image for LRFN1 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LRFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with LRFN1: view

Pathways for LRFN1 Gene

SuperPathways for LRFN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRFN1 Gene


No data available for Pathways by source for LRFN1 Gene

Transcripts for LRFN1 Gene

mRNA/cDNA for LRFN1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRFN1 Gene

Leucine rich repeat and fibronectin type III domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRFN1 Gene

No ASD Table

Relevant External Links for LRFN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRFN1 Gene

mRNA expression in normal human tissues for LRFN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRFN1 Gene

This gene is overexpressed in Whole Blood (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRFN1 Gene

SOURCE GeneReport for Unigene cluster for LRFN1 Gene Hs.97860

genes like me logo Genes that share expressions with LRFN1: view

Orthologs for LRFN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRFN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRFN1 36
  • 99.65 (n)
  • 99.74 (a)
LRFN1 37
  • 100 (a)
(Bos Taurus)
Mammalia LRFN1 36
  • 89.6 (n)
  • 95.71 (a)
LRFN1 37
  • 96 (a)
(Canis familiaris)
Mammalia LRFN1 36
  • 90.81 (n)
  • 96.36 (a)
LRFN1 37
  • 97 (a)
(Mus musculus)
Mammalia Lrfn1 36
  • 87.15 (n)
  • 96.34 (a)
Lrfn1 16
Lrfn1 37
  • 96 (a)
(Monodelphis domestica)
Mammalia LRFN1 37
  • 82 (a)
(Rattus norvegicus)
Mammalia Lrfn1 36
  • 86.97 (n)
  • 96.34 (a)
(Anolis carolinensis)
Reptilia LRFN1 37
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrfn1 36
  • 61.93 (n)
  • 66.91 (a)
(Danio rerio)
Actinopterygii mb21d2b 36
  • 67.23 (n)
  • 64.22 (a)
mb21d2b 37
  • 56 (a)
zgc63670 36
Species with no ortholog for LRFN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRFN1 Gene

Gene Tree for LRFN1 (if available)
Gene Tree for LRFN1 (if available)

Paralogs for LRFN1 Gene

Selected SIMAP similar genes for LRFN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LRFN1: view

Variants for LRFN1 Gene

Sequence variations from dbSNP and Humsavar for LRFN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs30476 -- 39,307,245(-) GCGAG(A/G)GGCCC utr-variant-3-prime
rs30477 -- 39,309,427(-) gccca(A/G)gctag intron-variant
rs30478 -- 39,310,045(-) ggaag(A/G)cagag intron-variant
rs30479 -- 39,312,308(-) GAGCC(C/T)CAGCT intron-variant
rs30480 -- 39,316,573(-) GTTTT(C/T)CTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRFN1 Gene

Variant ID Type Subtype PubMed ID
nsv833830 CNV Loss 17160897
nsv911679 CNV Loss 21882294
nsv911680 CNV Loss 21882294
nsv911681 CNV Loss 21882294

Relevant External Links for LRFN1 Gene

HapMap Linkage Disequilibrium report

Disorders for LRFN1 Gene

No disorders were found for LRFN1 Gene.

No data available for UniProtKB/Swiss-Prot for LRFN1 Gene

Publications for LRFN1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins. (PMID: 16828986) Morimura N. … Aruga J. (Gene 2006) 2 3
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for LRFN1 Gene

Sources for LRFN1 Gene

Back to Top