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LRFN1 Gene

protein-coding   GIFtS: 50
GCID: GC19M039798

Leucine Rich Repeat And Fibronectin Type III Domain Containing...

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat And Fibronectin Type III Domain Containing 11 2
SALM22 3 5
Synaptic Adhesion-Like Molecule 22 3
KIAA14843 5
Leucine-Rich Repeat And Fibronectin Type III Domain-Containing Protein 12

External Ids:    HGNC: 292901   Entrez Gene: 576222   Ensembl: ENSG000001280117   OMIM: 6128075   UniProtKB: Q9P2443   

Export aliases for LRFN1 gene to outside databases

Previous GC identifers: GC19M044489 GC19M036243


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRFN1 Gene:
LRFN1 (leucine rich repeat and fibronectin type III domain containing 1) is a protein-coding gene. An important paralog of this gene is LRFN3.

UniProtKB/Swiss-Prot: LRFN1_HUMAN, Q9P244
Function: Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of
excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1
and GRIN1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRFN1 gene promoter:
         GR   NF-1   GR-beta   CUTL1   Gfi-1   CREB   FAC1   deltaCREB   SEF-1 (1)   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for LRFN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRFN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

LRFN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRFN1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039798:  view genomic region     (about GC identifiers)

Start:
39,797,208 bp from pter      End:
39,805,976 bp from pter
Size:
8,769 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRFN1_HUMAN, Q9P244 (See protein sequence)
Recommended Name: Leucine-rich repeat and fibronectin type III domain-containing protein 1 precursor  
Size: 771 amino acids; 82318 Da
Subunit: Can form heteromeric complexes with LRFN2, LRFN3, LRFN4 and LRFN5 (By similarity). Forms homomeric
complexes, but not across cell junctions (By similarity). Interacts with DLG1, DLG2, DLG3 and DLG4. Interacts
with 2 AMPA receptor subunits GRIA1 and GRIA2 and NMDA receptor subunit GRIN1 (By similarity)
Secondary accessions: Q8TBS9

Explore the universe of human proteins at neXtProt for LRFN1: NX_Q9P244

Explore proteomics data for LRFN1 at MOPED

Post-translational modifications: 

  • Glycosylated (By similarity)1
  • Glycosylation2 at Asn87, Asn343
  • Modification sites at PhosphoSitePlus

  • See LRFN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065913.1  
    ENSEMBL proteins: 
     ENSP00000248668  

    LRFN1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for LRFN1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry Q9P244

    ProtoNet protein and cluster: Q9P244

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: LRFN1_HUMAN, Q9P244
    Domain: The PDZ-binding motif is required for neurite outgrowth promotion and for DLG1-, DLG3- and DLG4-binding
    (By similarity)
    Similarity: Belongs to the LRFN family
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 7 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with LRFN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRFN1_HUMAN, Q9P244
    Function: Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of
    excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1
    and GRIN1 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRFN1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRFN1
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    miRNA
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    miRTarBase miRNAs that target LRFN1:
    hsa-mir-10a-5p (MIRT047689)

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    Selected qRT-PCR Assays for microRNAs that regulate LRFN1 (see all 32):
    hsa-miR-3910 hsa-miR-300 hsa-miR-148b hsa-miR-658 hsa-miR-512-3p hsa-miR-766 hsa-miR-124 hsa-miR-375
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRFN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRFN1_HUMAN, Q9P244: Membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (By
    similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity).
    Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    plasma membrane3
    cytoskeleton2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014069postsynaptic density IEA--
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    Find genes that share ontologies with LRFN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRFN1
    Interactions:

        Search GeneGlobe Interaction Network for LRFN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for LRFN1 (Q9P2442, 3 ENSP000002486684) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RGS2P412202, 3, ENSP000002353824MINT-8268845 I2D: score=4 STRING: ENSP00000235382
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    YWHABP319463, ENSP000003001614I2D: score=1 STRING: ENSP00000300161
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    DLG4P783523I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRFN1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRFN1 gene: 
    NM_020862.1  

    Unigene Cluster for LRFN1:

    Leucine rich repeat and fibronectin type III domain containing 1
    Hs.97860  [show with all ESTs]
    Unigene Representative Sequence: NM_020862
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248668(uc002okw.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate LRFN1 (see all 32):
    hsa-miR-3910 hsa-miR-300 hsa-miR-148b hsa-miR-658 hsa-miR-512-3p hsa-miR-766 hsa-miR-124 hsa-miR-375
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LRFN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LRFN1
      QuantiTect SYBR Green Assays in human, mouse, rat LRFN1
      QuantiFast Probe-based Assays in human, mouse, rat LRFN1

    Additional mRNA sequence: 

    AB040917.1 BC014678.1 BC025310.1 BC040681.1 

    4 DOTS entries:

    DT.100015114  DT.95361590  DT.302801  DT.121468659 

    21 AceView cDNA sequences:

    AB040917 AW438634 BX109893 BC040681 BX444908 BC025310 AA402106 BX444907 
    BE393297 BM820430 AI734033 BQ276384 AA401995 AI821646 BF038187 BE393725 
    BE256121 BG818208 BF965547 BE393894 BC014678 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRFN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCCGAGA
    LRFN1 Expression
    About this image


    LRFN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Ovary (Reproductive System)
    LRFN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRFN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97860
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRFN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRFN1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrfn11 , 5 leucine rich repeat and fibronectin type III domain more1, 5 87.15(n)1
    96.34(a)1
      7 (16.77 cM)5
    807491  NM_001141921.11  NP_001135393.11 
     284586585 
    lizard
    (Anolis carolinensis)
    Reptilia LRFN16
    leucine rich repeat and fibronectin type III domai...
    70(a)
    1 ↔ 1
    GL343496.1(159103-160482)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrfn11 leucine rich repeat and fibronectin type III domain more 61.93(n)
    66.91(a)
      100487064  XM_002940361.2  XP_002940407.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636702 hypothetical protein MGC63670 77.65(n)   393587  BC056798.1 


    ENSEMBL Gene Tree for LRFN1 (if available)
    TreeFam Gene Tree for LRFN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRFN1 gene
    LRFN32  LRRN32  LINGO12  LRRC42  LRFN42  LINGO22  LRRC4B2  LRRN12  
    LRFN52  LRFN22  LRRC4C2  LINGO32  LRRN22  LINGO42  
    4 SIMAP similar genes for LRFN1 using alignment to 3 protein entries:     LRFN1_HUMAN (see all proteins):
    LRFN5    LRFN3    LRFN4    LRFN2

    Find genes that share paralogs with LRFN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRFN1 (see all 197)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426796211,2
    C--39797009(+) TTCACC/TCCTAT 1 -- int10--------
    rs1148568991,2
    C,F--39797018(+) ATAGTA/GGAGAC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1820337801,2
    --39797106(+) ATTCCC/TTCATC 1 -- int10--------
    rs1860108221,2
    --39797253(+) TCTAAG/TTCTCT 1 -- int10--------
    rs104205161,2
    C,F--39797287(+) AGTCTC/TCTCCG 1 -- int1 ese31Minor allele frequency- T:0.08WA 118
    rs1395387251,2
    --39797297(+) GGCCCC/TAGTTA 1 -- int10--------
    rs592346881,2
    C--39797412(+) CACAC-/AC/   
      ACACAC
    TACAC
    2 -- int1 cds11NA 2
    rs1889608981,2
    --39797501(+) GGTCCC/TGGCTC 1 -- ut310--------
    rs2519131,2
    C,F,H--39797716(+) CACTAC/TAGAGA 1 -- ut31 ese37Minor allele frequency- T:0.01NS EA NA 518
    rs1816598951,2
    --39797773(+) GGGGAA/CCCCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LRFN1 (39797208 - 39805976 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LRFN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911680CNV Loss21882294
    nsv911679CNV Loss21882294
    nsv833830CNV Loss17160897
    nsv911681CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612807    OMIM disorders: --


    Find genes that share disorders with LRFN1           About GenesLikeMe


    Export disorders for LRFN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRFN1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with LRFN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins. (PubMed id 16828986)1, 3 Morimura N....Aruga J. (Gene 2006)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    6. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (Science 2007)
    7. SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses. (PubMed id 16630835)2 Ko J.... Kim E. (Neuron 2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57622 HGNC: 29290 AceView: LRFN1 Ensembl:ENSG00000128011 euGenes: HUgn57622
    ECgene: LRFN1 H-InvDB: LRFN1

    (According to HUGE)
    About This Section

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    HUGE: KIAA1484

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LRFN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LRFN1 gene:
    Search GeneIP for patents involving LRFN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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