Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LRCH4 Gene

Aliases for LRCH4 Gene

  • Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 4 2 3
  • Leucine-Rich Neuronal Protein 3 4
  • LRRN1 3 4
  • LRRN4 3 4
  • LRN 3 4
  • Leucine-Rich Repeat And Calponin Homology Domain-Containing Protein 4 3
  • Leucine-Rich Repeat Neuronal Protein 4 4
  • Leucine Rich Repeat Neuronal 4 3
  • PP14183 3

External Ids for LRCH4 Gene

Previous Symbols for LRCH4 Gene

  • LRN
  • LRRN1

Summaries for LRCH4 Gene

Entrez Gene Summary for LRCH4 Gene

  • This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRCH4 Gene

LRCH4 (Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is LRRC30.

Gene Wiki entry for LRCH4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRCH4 Gene

Genomics for LRCH4 Gene

Genomic Location for LRCH4 Gene

Start:
100,574,011 bp from pter
End:
100,586,183 bp from pter
Size:
12,173 bases
Orientation:
Minus strand

Genomic View for LRCH4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRCH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRCH4 Gene

Regulatory Elements for LRCH4 Gene

Proteins for LRCH4 Gene

  • Protein details for LRCH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75427-LRCH4_HUMAN
    Recommended name:
    Leucine-rich repeat and calponin homology domain-containing protein 4
    Protein Accession:
    O75427
    Secondary Accessions:
    • A4D2D5
    • Q8WV85
    • Q96ID0

    Protein attributes for LRCH4 Gene

    Size:
    683 amino acids
    Molecular mass:
    73450 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC78793.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for LRCH4 Gene

Proteomics data for LRCH4 Gene at MOPED

Post-translational modifications for LRCH4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRCH4 Gene

No data available for DME Specific Peptides for LRCH4 Gene

Domains for LRCH4 Gene

UniProtKB/Swiss-Prot:

LRCH4_HUMAN
Domain:
  • Contains 1 CH (calponin-homology) domain.:
    • O75427
Similarity:
  • Contains 9 LRR (leucine-rich) repeats.:
    • O75427
genes like me logo Genes that share domains with LRCH4: view

No data available for Gene Families for LRCH4 Gene

Function for LRCH4 Gene

Gene Ontology (GO) - Molecular Function for LRCH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LRCH4: view

miRNA for LRCH4 Gene

miRTarBase miRNAs that target LRCH4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LRCH4 Gene

Localization for LRCH4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRCH4 Gene COMPARTMENTS Subcellular localization image for LRCH4 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRCH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016605 PML body IDA 16449650
genes like me logo Genes that share ontologies with LRCH4: view

Pathways for LRCH4 Gene

SuperPathways for LRCH4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRCH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9799793
genes like me logo Genes that share ontologies with LRCH4: view

No data available for Pathways by source for LRCH4 Gene

Transcripts for LRCH4 Gene

Unigene Clusters for LRCH4 Gene

Leucine-rich repeats and calponin homology (CH) domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRCH4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a ·
SP1: - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10: -
SP11:

ExUns: 17b ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25
SP1: -
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for LRCH4 Gene

GeneLoc Exon Structure for
LRCH4
ECgene alternative splicing isoforms for
LRCH4

Expression for LRCH4 Gene

mRNA expression in normal human tissues for LRCH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRCH4 Gene

This gene is overexpressed in Whole Blood (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRCH4 Gene

SOURCE GeneReport for Unigene cluster for LRCH4 Gene Hs.125742

genes like me logo Genes that share expressions with LRCH4: view

Orthologs for LRCH4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRCH4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRCH4 36
  • 99.51 (n)
  • 99.71 (a)
LRCH4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRCH4 36
  • 86.97 (n)
  • 88.01 (a)
LRCH4 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRCH4 36
  • 87.43 (n)
  • 88.08 (a)
LRCH4 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm20605 37
  • 86 (a)
OneToMany
Lrch4 36
  • 84.85 (n)
  • 85.76 (a)
Lrch4 16
Lrch4 37
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LRCH4 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrch4 36
  • 84.16 (n)
  • 84.77 (a)
lizard
(Anolis carolinensis)
Reptilia LRCH4 37
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100535148 36
  • 57.55 (n)
  • 55.33 (a)
lrch4 37
  • 45 (a)
OneToMany
LRCH4 (2 of 2) 37
  • 46 (a)
OneToMany
Species with no ortholog for LRCH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRCH4 Gene

ENSEMBL:
Gene Tree for LRCH4 (if available)
TreeFam:
Gene Tree for LRCH4 (if available)

Paralogs for LRCH4 Gene

Selected SIMAP similar genes for LRCH4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LRCH4: view

Variants for LRCH4 Gene

Sequence variations from dbSNP and Humsavar for LRCH4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs760142 -- 100,581,292(-) AGTAT(A/G)TAAAA intron-variant
rs909151 -- 100,578,065(-) GCAGA(A/G)GCTGG intron-variant
rs909152 -- 100,577,850(-) CGGGG(A/G)CCCAG reference, synonymous-codon
rs909153 -- 100,577,811(-) TAGCA(C/G)GGCTG intron-variant
rs2686809 -- 100,580,461(+) cacac(A/G)caaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRCH4 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv7398n71 CNV Loss 21882294
nsv888779 CNV Loss 21882294
dgv7399n71 CNV Loss 21882294
dgv7400n71 CNV Loss 21882294
nsv831072 CNV Loss 17160897
nsv888789 CNV Loss 21882294
nsv5868 CNV Loss 18451855

Relevant External Links for LRCH4 Gene

HapMap Linkage Disequilibrium report
LRCH4

Disorders for LRCH4 Gene

No disorders were found for LRCH4 Gene.

No data available for UniProtKB/Swiss-Prot for LRCH4 Gene

Publications for LRCH4 Gene

  1. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PMID: 9799793) Gloeckner G. … Rosenthal A. (Genome Res. 1998) 2 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for LRCH4 Gene

Sources for LRCH4 Gene

Back to Top

Content