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LRCH4 Gene

protein-coding   GIFtS: 50
GCID: GC07M100172

Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing...


(Previous symbols: LRN, LRRN1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 41 2     PP141832
LRN1 2 3     Leucine Rich Repeat Neuronal 42
LRRN11 2 3     Leucine-Rich Repeat And Calponin Homology Domain-Containing Protein 42
Leucine-Rich Neuronal Protein2 3     Leucine-Rich Repeat Neuronal Protein 43
LRRN42 3     

External Ids:    HGNC: 66911   Entrez Gene: 40342   Ensembl: ENSG000000774547   UniProtKB: O754273   

Export aliases for LRCH4 gene to outside databases

Previous GC identifers: GC07M099782 GC07M099814 GC07M100009 GC07M094803


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LRCH4 Gene:
This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be
involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements
suggest that the encoded protein resembles a receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for LRCH4 Gene:
LRCH4 (leucine-rich repeats and calponin homology (CH) domain containing 4) is a protein-coding gene. An important paralog of this gene is LRRC2.

Gene Wiki entry for LRCH4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRCH4 gene promoter:
         Sox5   Sp1   Nkx2-5   NF-kappaB   GATA-1   PPAR-gamma1   FAC1   Pax-3   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): LRCH4 promoter sequence
   Search Chromatin IP Primers for LRCH4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRCH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

LRCH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRCH4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100172:  view genomic region     (about GC identifiers)

Start:
100,169,855 bp from pter      End:
100,183,776 bp from pter
Size:
13,922 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,531,269-99,543,409     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LRCH4_HUMAN, O75427 (See protein sequence)
Recommended Name: Leucine-rich repeat and calponin homology domain-containing protein 4  
Size: 683 amino acids; 73450 Da
Sequence caution: Sequence=AAC78793.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D2D5 Q8WV85 Q96ID0

Explore the universe of human proteins at neXtProt for LRCH4: NX_O75427

Explore proteomics data for LRCH4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LRCH4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001276863.1  NP_002310.2  

    ENSEMBL proteins: 
     ENSP00000419674   ENSP00000309689   ENSP00000419870  

    LRCH4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for LRCH4

     
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    antibodies-online proteins for LRCH4 (3 products) 

     
    antibodies-online peptides for LRCH4

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    antibodies-online antibodies for LRCH4 (24 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001715 CH-domain
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry O75427

    ProtoNet protein and cluster: O75427

    2 Blocks protein domains:
    IPB001611 Leucine-rich repeat signature
    IPB001715 Calponin-like actin-binding


    UniProtKB/Swiss-Prot: LRCH4_HUMAN, O75427
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 9 LRR (leucine-rich) repeats


    Find genes that share domains with LRCH4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with LRCH4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRCH4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRCH4

    miRNA
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    miRTarBase miRNAs that target LRCH4:
    hsa-mir-484 (MIRT042268), hsa-mir-423-5p (MIRT038138)

    Block miRNA regulation of human, mouse, rat LRCH4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRCH4 (see all 31):
    hsa-miR-485-5p hsa-miR-185* hsa-miR-503 hsa-miR-759 hsa-miR-340 hsa-miR-877* hsa-miR-511 hsa-miR-1265
    SwitchGear 3'UTR luciferase reporter plasmidLRCH4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LRCH4

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    GenScript: all cDNA clones in your preferred vector: LRCH4 (NM_002319)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016605PML body IDA16449650

    Find genes that share ontologies with LRCH4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRCH4
    Interactions:

        Search GeneGlobe Interaction Network for LRCH4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for LRCH4 (O754271, 3 ENSP000003096894) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 3, ENSP000002303214EBI-718707,EBI-724076 I2D: score=4 STRING: ENSP00000230321
    RTN4Q9NQC33, ENSP000003378384I2D: score=4 STRING: ENSP00000337838
    RBBP6Q7Z6E93, ENSP000003178724I2D: score=2 STRING: ENSP00000317872
    TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development TAS9799793

    Find genes that share ontologies with LRCH4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRCH4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRCH4 gene (2 alternative transcripts): 
    NM_001289934.1  NM_002319.4  

    Unigene Cluster for LRCH4:

    Leucine-rich repeats and calponin homology (CH) domain containing 4
    Hs.125742  [show with all ESTs]
    Unigene Representative Sequence: NM_002319
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485071(uc003uvh.3 uc010lgz.3 uc003uvi.3 uc011kjw.1)
    ENST00000485554 ENST00000467201 ENST00000310300(uc003uvj.3 uc011kjx.1)
    ENST00000476881 ENST00000497245 ENST00000490359 ENST00000498539 ENST00000487697
    ENST00000470184 ENST00000485583
    miRNA
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    Block miRNA regulation of human, mouse, rat LRCH4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRCH4 (see all 31):
    hsa-miR-485-5p hsa-miR-185* hsa-miR-503 hsa-miR-759 hsa-miR-340 hsa-miR-877* hsa-miR-511 hsa-miR-1265
    SwitchGear 3'UTR luciferase reporter plasmidLRCH4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LRCH4
    Predesigned siRNA for gene silencing in human, mouse, rat LRCH4
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    OriGene ORF clones in mouse, rat for LRCH4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRCH4 (NM_002319)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRCH4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRCH4
    Primer
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    OriGene qPCR primer pairs and template standards for LRCH4
    OriGene qSTAR qPCR primer pairs in human, mouse for LRCH4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRCH4
      QuantiTect SYBR Green Assays in human, mouse, rat LRCH4
      QuantiFast Probe-based Assays in human, mouse, rat LRCH4

    Additional mRNA sequence: 

    AF459638.1 AK074833.1 AK097420.1 BC007634.1 BC018529.1 FR717257.1 HQ401361.1 

    17 DOTS entries:

    DT.446923  DT.95366153  DT.100779313  DT.100835466  DT.95344174  DT.100779311  DT.91942699  DT.121039567 
    DT.121039618  DT.100779312  DT.40132404  DT.95155267  DT.95366149  DT.95366150  DT.100684627  DT.100680477 
    DT.100779315 

    Selected AceView cDNA sequences (see all 211):

    BF797367 BI835263 CR597686 BU621579 CR605636 CA489881 BI518408 CR610208 
    AI992313 BM474575 CN478530 AI026884 BF594777 AK097420 BI766848 BU527456 
    BI910714 AK074833 AW176705 BG392369 BM680894 BI908556 BC018529 BF594782 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LRCH4 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17a ·
    SP1:              -           -                 -                                                                                         -     -               
    SP2:                          -                 -                                                                                         -     -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17b ^ 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25
    SP1:              -                                                                     
    SP2:              -                                                                     
    SP3:                                                  -     -                           
    SP4:              -                                                                     
    SP5:                                                                                    


    ECgene alternative splicing isoforms for LRCH4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRCH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCGGAGC
    LRCH4 Expression
    About this image


    LRCH4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Thymus (Hematopoietic System)
    LRCH4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRCH4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125742
        Custom PCR Arrays for LRCH4
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    QuantiFast Probe-based Assays in human, mouse, rat LRCH4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRCH4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRCH4 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrch41 , 5 leucine-rich repeats and calponin homology (CH) domain more1, 5 84.85(n)1
    85.76(a)1
      5 (76.59 cM)5
    2317981  NM_146164.21  NP_666276.11 
     1376291215 
    lizard
    (Anolis carolinensis)
    Reptilia LRCH46
    leucine-rich repeats and calponin homology (CH) do...
    38(a)
    1 ↔ 1
    GL344413.1(1007-21133)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005351481 leucine-rich repeat and calponin homology domain-containing more 57.55(n)
    55.33(a)
      100535148  XM_003199005.2  XP_003199053.2 


    ENSEMBL Gene Tree for LRCH4 (if available)
    TreeFam Gene Tree for LRCH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRCH4 gene
    LRRC22  LRCH22  LRRC182  LRSAM12  LRRC302  PIDD2  LRCH32  LRRC572  
    LRRC10B2  LRRC392  LRRC102  LRCH12  
    4 SIMAP similar genes for LRCH4 using alignment to 3 protein entries:     LRCH4_HUMAN (see all proteins):
    LRCH2    LRCH1    LRCH3    CNN3

    Find genes that share paralogs with LRCH4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRCH4 (see all 304)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154873841,2
    C--100173281(+) ATGCTC/TGGCTG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs775892801,2
    C--100173282(+) TGCTCA/GGCTGA 1 -- int10--------
    rs2007551001,2
    --100173290(+) TGAGTA/CCGGCA 1 -- int10--------
    rs1998783041,2
    C--100173292(+) AGTCCA/GGCATG 1 -- int10--------
    rs2014790021,2
    --100173452(+) ACAGGC/TGCCCC 1 -- int10--------
    rs20756681,2
    C,F,H--100173481(-) GGGGCT/CGGGGA 1 -- int121Minor allele frequency- C:0.19EA NS NA WA CSA EU 4223
    rs2013529571,2
    --100173527(+) GGCACA/GGAGCG 2 S syn10--------
    rs1999957421,2
    C--100173562(+) GCACAG/TGATGA 2 M L mis10--------
    rs1873580951,2
    C,F--100173636(+) CCTGGC/AAGTGT 1 -- int11Minor allele frequency- A:0.01EU 459
    rs2021320871,2
    C--100173650(+) CCACAC/TAGAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for LRCH4 (100169855 - 100183776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for LRCH4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    dgv7398n71CNV Loss21882294
    dgv7400n71CNV Loss21882294
    nsv888789CNV Loss21882294
    nsv888779CNV Loss21882294
    dgv7399n71CNV Loss21882294
    nsv831072CNV Loss17160897
    nsv5868CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRCH4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with LRCH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PubMed id 9799793)1, 2, 3 Gloeckner G.... Rosenthal A. (Genome Res. 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    5. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. (PubMed id 20508642)1 Krebs A.R....Tora L. (EMBO Rep. 2010)
    6. LRCH proteins: a novel family of cytoskeletal regulators. (PubMed id 20805893)1 Foussard H....Payre F. (PLoS ONE 2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    9. RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. (PubMed id 18851979)1 Chibi M....Pugh D.J. (J. Mol. Biol. 2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4034 HGNC: 6691 AceView: LRCH4 Ensembl:ENSG00000077454 euGenes: HUgn4034
    ECgene: LRCH4 H-InvDB: LRCH4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRCH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRCH4 gene:
    Search GeneIP for patents involving LRCH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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