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Aliases for LRCH2 Gene

Aliases for LRCH2 Gene

  • Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 2 2 3
  • DA204F4.4 3
  • KIAA1495 4

External Ids for LRCH2 Gene

Previous GeneCards Identifiers for LRCH2 Gene

  • GC0XM113110
  • GC0XM114168
  • GC0XM114251
  • GC0XM114345
  • GC0XM103930

Summaries for LRCH2 Gene

Entrez Gene Summary for LRCH2 Gene

  • This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. These family members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species, and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for LRCH2 Gene

LRCH2 (Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is LRRC30.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRCH2 Gene

Genomics for LRCH2 Gene

Regulatory Elements for LRCH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRCH2 Gene

115,110,616 bp from pter
115,234,075 bp from pter
123,460 bases
Minus strand

Genomic View for LRCH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRCH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRCH2 Gene

Proteins for LRCH2 Gene

  • Protein details for LRCH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat and calponin homology domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • F5H2T1
    • Q08AD5
    • Q9HA88
    • Q9P233

    Protein attributes for LRCH2 Gene

    765 amino acids
    Molecular mass:
    84588 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA96019.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70721.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI42077.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI43033.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRCH2 Gene


neXtProt entry for LRCH2 Gene

Proteomics data for LRCH2 Gene at MOPED

Post-translational modifications for LRCH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRCH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRCH2 Gene

Domains & Families for LRCH2 Gene

Suggested Antigen Peptide Sequences for LRCH2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CH (calponin-homology) domain.
  • Contains 9 LRR (leucine-rich) repeats.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 9 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRCH2: view

No data available for Gene Families for LRCH2 Gene

Function for LRCH2 Gene

Gene Ontology (GO) - Molecular Function for LRCH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRCH2: view

Phenotypes for LRCH2 Gene

genes like me logo Genes that share phenotypes with LRCH2: view

Animal Model Products

miRNA for LRCH2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRCH2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LRCH2 Gene

Localization for LRCH2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LRCH2 Gene

Pathways & Interactions for LRCH2 Gene

SuperPathways for LRCH2 Gene

No Data Available

Interacting Proteins for LRCH2 Gene

Gene Ontology (GO) - Biological Process for LRCH2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRCH2 Gene

Drugs & Compounds for LRCH2 Gene

No Compound Related Data Available

Transcripts for LRCH2 Gene

Unigene Clusters for LRCH2 Gene

Leucine-rich repeats and calponin homology (CH) domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRCH2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRCH2 Gene

No ASD Table

Relevant External Links for LRCH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRCH2 Gene

mRNA expression in normal human tissues for LRCH2 Gene

Protein differential expression in normal tissues from HIPED for LRCH2 Gene

This gene is overexpressed in Frontal cortex (33.5) and Adrenal (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRCH2 Gene

SOURCE GeneReport for Unigene cluster for LRCH2 Gene Hs.65366

genes like me logo Genes that share expression patterns with LRCH2: view

Protein tissue co-expression partners for LRCH2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRCH2 Gene

Orthologs for LRCH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRCH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRCH2 35
  • 94.04 (n)
  • 94.12 (a)
(Canis familiaris)
Mammalia LRCH2 35
  • 94.82 (n)
  • 96.67 (a)
LRCH2 36
  • 96 (a)
(Mus musculus)
Mammalia Lrch2 35
  • 90.56 (n)
  • 93.61 (a)
Lrch2 16
Lrch2 36
  • 92 (a)
(Pan troglodytes)
Mammalia LRCH2 35
  • 96.75 (n)
  • 96.24 (a)
LRCH2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Lrch2 35
  • 90.64 (n)
  • 93.18 (a)
(Monodelphis domestica)
Mammalia LRCH2 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia LRCH2 36
  • 68 (a)
(Gallus gallus)
Aves LRCH2 35
  • 80.3 (n)
  • 83.47 (a)
LRCH2 36
  • 81 (a)
(Anolis carolinensis)
Reptilia LRCH2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrch2 35
  • 74.11 (n)
  • 76.51 (a)
Str.4233 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33837 35
(Danio rerio)
Actinopterygii LOC101882684 35
  • 65.87 (n)
  • 70.84 (a)
lrch2 36
  • 66 (a)
Species with no ortholog for LRCH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRCH2 Gene

Gene Tree for LRCH2 (if available)
Gene Tree for LRCH2 (if available)

Paralogs for LRCH2 Gene

(4) SIMAP similar genes for LRCH2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRCH2: view

Variants for LRCH2 Gene

Sequence variations from dbSNP and Humsavar for LRCH2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1575119 -- 115,115,897(+) ttcaa(C/T)agaca intron-variant
rs1575120 -- 115,116,011(+) acata(C/T)acact intron-variant
rs2310838 -- 115,117,616(-) ttgct(C/G)ttcat intron-variant
rs2495398 -- 115,146,906(+) ATACA(C/T)ACACA intron-variant
rs2752860 -- 115,110,856(+) CACTT(C/G)TTTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LRCH2 Gene

Variant ID Type Subtype PubMed ID
esv33994 CNV Gain+Loss 17666407
nsv513764 CNV Insertion 21212237
nsv511667 CNV Gain 21212237
nsv516624 CNV Gain 19592680
nsv520351 CNV Gain 19592680
esv1448157 CNV Deletion 17803354
esv271901 CNV Insertion 20981092

Variation tolerance for LRCH2 Gene

Gene Damage Index Score: 1.23; 24.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRCH2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRCH2 Gene

Disorders for LRCH2 Gene

Relevant External Links for LRCH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LRCH2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRCH2 Gene

Publications for LRCH2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A systems-wide screen identifies substrates of the SCFI^TrCP ubiquitin ligase. (PMID: 25515538) Low T.Y. … Heck A.J. (Sci Signal 2014) 67
  4. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 67
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 67

Products for LRCH2 Gene

Sources for LRCH2 Gene

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