LRCH2 Gene
protein-coding GIFtS: 45
GCID: GC0XM114345
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leucine-rich repeats and calponin homology (CH) domain containing...
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Aliases
for LRCH2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 21 2 | | KIAA14951 3 | | DA204F4.41 | | Leucine-Rich Repeat And Calponin Homology Domain-Containing Protein 22 |
Export aliases for LRCH2 gene to outside databasesPrevious GC identifers: GC0XM113110 GC0XM114168 GC0XM114251 GC0XM103930 |
Summaries
for LRCH2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LRCH2:
This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. Thesefamily members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain,a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species,and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternativesplicing of this gene results in multiple transcript variants. (provided by RefSeq, Sep 2011)
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Genomic Views
for LRCH2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_028405.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRCH2 gene promoter:
GR Egr-3 NF-YA NF-YB CBF-A CBF-B GR-alpha CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRCH2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRCH2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq23 Ensembl cytogenetic band: Xq23 HGNC cytogenetic band: Xq24LRCH2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM114345: view genomic region
(about GC identifiers)
Start:
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114,345,179 bp from pter |
End:
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114,468,635 bp from pter |
Size:
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123,457 bases |
Orientation:
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minus strand |
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Proteins
for LRCH2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRCH2_HUMAN, Q5VUJ6 (See
protein sequence)Recommended Name: Leucine-rich repeat and calponin homology domain-containing protein 2 Size: 765 amino acids; 84588 Da
Sequence caution: Sequence=BAA96019.1; Type=Erroneous initiation; Sequence=CAH70721.1; Type=Erroneous gene modelprediction; Sequence=CAI42077.1; Type=Erroneous gene model prediction; Sequence=CAI43033.1; Type=Erroneous gene modelprediction;
Secondary accessions: F5H2T1 Q08AD5 Q9HA88 Q9P233Alternative splicing: 2 isoforms: Q5VUJ6-1 Q5VUJ6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for LRCH2: NX_Q5VUJ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VUJ6
LRCH2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001230892.1 NP_065922.3
ENSEMBL proteins: ENSP00000325091 ENSP00000439366
Human Recombinant Protein Products:
LRCH2 Antibody Products:
Assay Products for LRCH2: |
Protein
Domains /
Families
for LRCH2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRCH2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VUJ6ProtoNet protein and cluster: Q5VUJ6 2 Blocks protein families: IPB001611 Leucine-rich repeat signature IPB001715 Calponin-like actin-binding
UniProtKB/Swiss-Prot: LRCH2_HUMAN, Q5VUJ6Similarity: Contains 1 CH (calponin-homology) domainSimilarity: Contains 9 LRR (leucine-rich) repeats |
Function
for LRCH2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRCH2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRCH2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for LRCH2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRCH2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRCH2 |
2 GenomeRNAi human phenotypes for LRCH2:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Lrch2):
LRCH2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for LRCH2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRCH2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for LRCH2 (Q5VUJ63 ENSP000003250914) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for LRCH2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRCH2
Search CenterWatch for drugs/clinical trials and news about LRCH2
|
Transcripts
for LRCH2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRCH2 gene (2 alternative transcripts): NM_001243963.1 NM_020871.3 Unigene Cluster for LRCH2: Leucine-rich repeats and calponin homology (CH) domain containing 2 Hs.65366 [show with all ESTs]Unigene Representative Sequence: BX6471932 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000317135(uc010nqe.3 uc004epz.3) ENST00000538422
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRCH2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRCH2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LRCH2 (NM_020871) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRCH2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRCH2 |
Additional cDNA sequence: AB040928.1 AK022128.1 BC042004.1 BC125223.1 BC125224.1 BX647193.1 2 DOTS entries: DT.408106 DT.121306180 24/62 AceView cDNA sequences (see all 62): AB040928 BM667709 Z40300 AI014456 AI335797 BX647193 AU121179 BX105175 BM710863 T16722 CD673145 NM_020871 AI401349 BU677917 AW470144 AI289313 BX505451 CR623574 BF036177 BC042004 D61488 AI189112 BM724234 BI914342
GeneLoc Exon Structure
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Expression
for LRCH2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRCH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCCCTACA
About this image
See LRCH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRCH2
SOURCE GeneReport for Unigene cluster: Hs.65366
SABiosciences Custom PCR Arrays for LRCH2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRCH2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRCH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRCH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRCH2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRCH2 |
Orthologs
for LRCH2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for LRCH2 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LRCH21 |
leucine-rich repeats and calponin homology (CH) domain more |
79.55(n)
82.68(a) |
|
422220 XM_420210.2 XP_420210.2 |
lizard
(Anolis carolinensis) |
Reptilia |
LRCH26 |
-- |
77(a) |
1 ↔ 1 |
GL343403.1(677303-718060) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.338372 |
Xenopus laevis transcribed sequence with moderate similarity more |
80.14(n) |
|
AW646020.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
lrch21 |
leucine-rich repeats and calponin homology (CH) domain more |
65.74(n)
71.74(a) |
|
100150488 XM_001921894.2 XP_001921929.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Lrch1 |
Leucine-rich-repeats and calponin homology domain protein |
44.13(n)
37.34(a) |
|
35041 NM_165212.1 NP_724046.1 |
ENSEMBL Gene Tree for LRCH2 (if available)
TreeFam Gene Tree for LRCH2 (if available) |
Paralogs
for LRCH2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRCH2 gene
- RSU12 LRSAM12 LRCH32 LRCH42 LRCH12
4 SIMAP similar genes for LRCH2 using alignment to 2 protein entries: LRCH2_HUMAN (see all proteins):LRCH3 LRCH1 LRCH4 RSU1
LRCH2 for paralogs About GeneDecksing
|
Genomic Variants
for LRCH2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRCH2 (114345179 - 114468635 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for LRCH2
4 CNVs: 83683 7758 96900 52912
2 Indels: 83684 29231
Locus Specific Mutation Databases (LSDB): LRCH2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRCH2 |
|
Disorders
/ Diseases
for LRCH2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for LRCH2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRCH2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with LRCH2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human leucine-rich repeat proteins: a genome-wide bio informatic categorization and functional analysis in innate immunity. (PubMed id 20616063)1 Ng A.C....Xavier R.J. (2011)
- Leucine-rich repeat (LRR) proteins: integrators of pa ttern recognition and signaling in immunity. (PubMed id 21606681)1 Ng A. and Xavier R.J. (2011)
- LRCH proteins: a novel family of cytoskeletal regulat ors. (PubMed id 20805893)1 Foussard H....Payre F. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for LRCH2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LRCH2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRCH2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing LRCH2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRCH2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for LRCH2 gene:
Search GeneIP for patents involving LRCH2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRCH2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRCH2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRCH2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRCH2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRCH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRCH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRCH2 |
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 | | | LRCH2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRCH2 |
|  |  |  | | | | Search ThermoFisher Antibodies for LRCH2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRCH2 |
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