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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRCH1 Gene

protein-coding   GIFtS: 50
GCID: GC13P047127

Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing...

(Previous name: calponin homology (CH) domain containing 1)
(Previous symbol: CHDC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 11 2     KIAA10163 5
CHDC11 2 3     Calponin Homology (CH) Domain Containing 11
Neuronal Protein 812 3     Leucine-Rich Repeat And Calponin Homology Domain-Containing Protein 12
NP812 3     Calponin Homology Domain-Containing Protein 13

External Ids:    HGNC: 203091   Entrez Gene: 231432   Ensembl: ENSG000001361417   OMIM: 6103685   UniProtKB: Q9Y2L93   

Export aliases for LRCH1 gene to outside databases

Previous GC identifers: GC13P044925 GC13P046025 GC13P027920


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LRCH1 Gene:
This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene
may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple
transcript variants encoding different isoforms. (provided by RefSeq, Mar 2010)

GeneCards Summary for LRCH1 Gene: 
LRCH1 (leucine-rich repeats and calponin homology (CH) domain containing 1) is a protein-coding gene. Diseases associated with LRCH1 include osteoarthritis, and neuronitis. An important paralog of this gene is LRRC8E.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRCH1 gene promoter:
         AhR   Lmo2   IRF-1   Arnt   FOXJ2 (long isoform)   Cart-1   STAT3   ZIC2/Zic2   FOXJ2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRCH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRCH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRCH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11   Ensembl cytogenetic band:  13q14.13   HGNC cytogenetic band: 13q14.11

LRCH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRCH1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P047127:  view genomic region     (about GC identifiers)

Start:
47,127,296 bp from pter      End:
47,327,176 bp from pter
Size:
199,881 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LRCH1_HUMAN, Q9Y2L9 (See protein sequence)
Recommended Name: Leucine-rich repeat and calponin homology domain-containing protein 1  
Size: 728 amino acids; 80875 Da
Sequence caution: Sequence=BAA76860.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAH70793.1; Type=Erroneous gene model prediction; Sequence=CAH73643.1; Type=Erroneous gene model
prediction; Sequence=CAI12229.1; Type=Erroneous gene model prediction;
Secondary accessions: B7ZLL5 F8W6F0 Q17R43 Q2KHR1 Q5TBU9 Q7Z5F6 Q7Z5F7
Alternative splicing: 3 isoforms:  Q9Y2L9-1   Q9Y2L9-2   Q9Y2L9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRCH1: NX_Q9Y2L9

Explore proteomics data for LRCH1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2L9

  • LRCH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRCH1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001157683.1  NP_001157685.1  NP_055931.1  

    ENSEMBL proteins: 
     ENSP00000308493   ENSP00000374448   ENSP00000374447   ENSP00000417121   ENSP00000419256  

    Human Recombinant Protein Products for LRCH1: 
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    OriGene Protein Over-expression Lysate for LRCH1
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    Novus Biologicals LRCH1 Lysate
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for LRCH1 


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    LSBio Antibodies in human, mouse, rat for LRCH1 

    Assay Products for LRCH1: 
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    Cloud-Clone Corp. ELISAs for LRCH1 
    Cloud-Clone Corp. CLIAs for LRCH1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001715 CH-domain
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q9Y2L9

    ProtoNet protein and cluster: Q9Y2L9

    1 Blocks protein domain: IPB001715 Calponin-like actin-binding

    UniProtKB/Swiss-Prot: LRCH1_HUMAN, Q9Y2L9
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 9 LRR (leucine-rich) repeats


    LRCH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    LRCH1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRCH1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRCH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRCH1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRCH1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRCH1
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate LRCH1 (see all 100):
    hsa-miR-3152-3p hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p hsa-miR-192* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidLRCH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LRCH1 (see all 15)
    OriGene ORF clones in mouse, rat for LRCH1
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    GenScript: all cDNA clones in your preferred vector (see all 3): LRCH1 (NM_015116)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRCH1
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                         Customized lentivirus expression plasmids for stable overexpression of LRCH1 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRCH1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRCH1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for LRCH1 (Q9Y2L93 ENSP000003744484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840223, ENSP000003329734I2D: score=1 STRING: ENSP00000332973
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRCH1

    Search CenterWatch for drugs/clinical trials and news about LRCH1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRCH1 gene (3 alternative transcripts): 
    NM_001164211.1  NM_001164213.1  NM_015116.2  

    Unigene Cluster for LRCH1:

    Leucine-rich repeats and calponin homology (CH) domain containing 1
    Hs.507971  [show with all ESTs]
    Unigene Representative Sequence: NM_001164211
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311191(uc001vbl.4) ENST00000443945(uc010acp.2) ENST00000389798(uc001vbk.3 uc001vbj.3)
    ENST00000389797 ENST00000463929 ENST00000478412
    miRNA
    Products:
         
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    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate LRCH1 (see all 100):
    hsa-miR-3152-3p hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p hsa-miR-192* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidLRCH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRCH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRCH1
    Clone
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    OriGene clones in human, mouse for LRCH1 (see all 15)
    OriGene ORF clones in mouse, rat for LRCH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LRCH1 (NM_015116)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRCH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRCH1
    Sirion Biotech Customized lentivirus for stable overexpression of LRCH1 
                         Customized lentivirus expression plasmids for stable overexpression of LRCH1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LRCH1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRCH1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRCH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRCH1

    Additional mRNA sequence: 

    AB023233.1 AK292898.1 AK309937.1 AY050631.1 AY050632.1 BC026097.1 BC112937.1 BC117472.1 
    BC143883.1 

    8 DOTS entries:

    DT.443266  DT.99984303  DT.428438  DT.95115501  DT.40291208  DT.120761698  DT.120761761  DT.97808141 

    24/94 AceView cDNA sequences (see all 94):

    AI245862 BQ709919 BE018226 AA278553 AI038371 BE044078 BQ421909 AI094735 
    AA251355 AI188546 AI080462 AA011538 AI308154 CD514335 AW105617 BE551517 
    AI969570 AI628341 AA579863 BF328431 BM991796 BM981950 CB999464 NM_015116 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRCH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTACCCC
    LRCH1 Expression
    About this image


    See LRCH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRCH1

    SOURCE GeneReport for Unigene cluster: Hs.507971
        SABiosciences Custom PCR Arrays for LRCH1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LRCH1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRCH1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRCH1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRCH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRCH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LRCH1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrch11 , 5 leucine-rich repeats and calponin homology (CH) domain more1, 5 85.19(n)1
    87.63(a)1
      14 (39.39 cM)5
    3809161  NM_001033439.31  NP_001028611.21 
     747546745 
    chicken
    (Gallus gallus)
    Aves LRCH11 leucine-rich repeats and calponin homology (CH) domain more 76.84(n)
    77.75(a)
      418855  XM_417050.3  XP_417050.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.196252 Xenopus laevis transcribed sequence with weak similarity more 77.72(n)    BX843582.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-260b17.81 si:ch211-260b17.8 64.05(n)
    67.06(a)
      560885  XM_684284.4  XP_689376.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lrch6
    Leucine-rich-repeats and calponin homology domain ...
    21(a)
    1 → many
    2L(17367509-17384147)


    ENSEMBL Gene Tree for LRCH1 (if available)
    TreeFam Gene Tree for LRCH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LRCH1 gene
    LRRC8E2  LRCH22  RSU12  LRRC182  LRSAM12  LRRC8A2  ENSG000002719492  PIDD2  
    LRCH32  LRRC8D2  LRRC572  LRRC282  LRRC8B2  LRRC8C2  LRCH42  
    7 SIMAP similar genes for LRCH1 using alignment to 4 protein entries:     LRCH1_HUMAN (see all proteins):
    LRCH2    LRCH4    LRRD1    LRRC57    LRCH3    LRRC28
    CNN3

    LRCH1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3962 SNPs in LRCH1 are shown (see all 3962)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0511334
    ----see VAR_0511332 S P mis40--------
    rs1383504281,2
    C--27936774(+) TCCTT-/TATTTC 3 -- int10--------
    rs1490312931,2
    C--27943210(+) ATGAA-/TGTG/T
    GTGTGTGTG
    TGTGT
    3 -- int10--------
    rs595827841,2
    C--27943245(+) TGTGT-/G/GTG 
    T
    /GTGTGT
    TGTGG
    6 -- int1 cds10--------
    rs116186791,2
    H--27943246(+) tgtgtG/TGTGGG 3 -- int10--------
    rs116175281,2
    H--27943247(+) gtgtTG/TTGGGG 3 -- int10--------
    rs2011387911,2
    --27950191(+) TTGTT-/GTTTTT 3 -- int10--------
    rs669145191,2
    C--27951466(+) TCTATT/-TTTTT 3 -- int11Minor allele frequency- -:0.00NA 2
    rs106094001,2
    C--27952672(+) CTTTC-/AT/TA 
            
    ACAAC
    3 -- int11NA 2
    rs105681991,2
    C--27952673(+) TTTCATA/-CAACT 3 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for LRCH1 (47127296 - 47327176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LRCH1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747365CNV Deletion23290073
    esv1496328CNV Insertion17803354
    esv988509CNV Insertion20482838
    nsv1026CNV Insertion18451855
    nsv455876CNV Gain19166990
    esv259618OTHER Complex20981092


    Human Gene Mutation Database (HGMD): LRCH1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LRCH1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRCH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610368    OMIM disorders: --

    2 diseases for LRCH1:    About MalaCards
    osteoarthritis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for LRCH1:
    Osteoarthritis

    LRCH1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LRCH1
    Human Genome Epidemiology (HuGE) Navigator: LRCH1 (4 documents)

    Export disorders for LRCH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRCH1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with LRCH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Field synopsis and synthesis of genetic association s tudies in osteoarthritis: the CUMAGAS-OSTEO information system. (PubMed id 20237151)1, 4 Zintzaras E....Karachalios T. (2010)
    3. Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility. (PubMed id 18049793)1, 4 Jiang Q....Ikegawa S. (2008)
    4. Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus. (PubMed id 16891653)1, 4 Snelling S....Loughlin J. (2007)
    5. Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling. (PubMed id 16447229)1, 4 Spector T.D....Braun A. (2006)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
    8. Genetic association analysis of LRCH-1 for knee osteoa rthritis. (PubMed id 22325041)1 Shin M.H....Kim T.J. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. LRCH proteins: a novel family of cytoskeletal regulat ors. (PubMed id 20805893)1 Foussard H....Payre F. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23143 HGNC: 20309 AceView: LRCH1 Ensembl:ENSG00000136141 euGenes: HUgn23143
    ECgene: LRCH1 H-InvDB: LRCH1

    (According to HUGE)
    About This Section
    HUGE: KIAA1016

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRCH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LRCH1 gene:
    Search GeneIP for patents involving LRCH1

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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