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LRCH1 Gene

protein-coding   GIFtS: 50
GCID: GC13P047127

Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing...

(Previous name: calponin homology (CH) domain containing 1)
(Previous symbol: CHDC1)
  See LRCH1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine-Rich Repeats And Calponin Homology (CH) Domain Containing 11 2     KIAA10163 5
CHDC11 2 3     Calponin Homology (CH) Domain Containing 11
Neuronal Protein 812 3     Leucine-Rich Repeat And Calponin Homology Domain-Containing Protein 12
NP812 3     Calponin Homology Domain-Containing Protein 13

External Ids:    HGNC: 203091   Entrez Gene: 231432   Ensembl: ENSG000001361417   OMIM: 6103685   UniProtKB: Q9Y2L93   

Export aliases for LRCH1 gene to outside databases

Previous GC identifers: GC13P044925 GC13P046025 GC13P027920


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LRCH1 Gene:
This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene
may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple
transcript variants encoding different isoforms. (provided by RefSeq, Mar 2010)

GeneCards Summary for LRCH1 Gene:
LRCH1 (leucine-rich repeats and calponin homology (CH) domain containing 1) is a protein-coding gene. Diseases associated with LRCH1 include osteoarthritis. An important paralog of this gene is LRRC2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRCH1 gene promoter:
         AhR   Lmo2   IRF-1   Arnt   FOXJ2 (long isoform)   Cart-1   STAT3   ZIC2/Zic2   FOXJ2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRCH1 promoter sequence
   Search Chromatin IP Primers for LRCH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRCH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.11   Ensembl cytogenetic band:  13q14.13   HGNC cytogenetic band: 13q14.11

LRCH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRCH1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P047127:  view genomic region     (about GC identifiers)

Start:
47,127,296 bp from pter      End:
47,327,176 bp from pter
Size:
199,881 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRCH1_HUMAN, Q9Y2L9 (See protein sequence)
Recommended Name: Leucine-rich repeat and calponin homology domain-containing protein 1  
Size: 728 amino acids; 80875 Da
Sequence caution: Sequence=BAA76860.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAH70793.1; Type=Erroneous gene model prediction; Sequence=CAH73643.1; Type=Erroneous gene model
prediction; Sequence=CAI12229.1; Type=Erroneous gene model prediction;
Secondary accessions: B7ZLL5 F8W6F0 Q17R43 Q2KHR1 Q5TBU9 Q7Z5F6 Q7Z5F7
Alternative splicing: 3 isoforms:  Q9Y2L9-1   Q9Y2L9-2   Q9Y2L9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRCH1: NX_Q9Y2L9

Explore proteomics data for LRCH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LRCH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001157683.1  NP_001157685.1  NP_055931.1  

    ENSEMBL proteins: 
     ENSP00000308493   ENSP00000374448   ENSP00000374447   ENSP00000417121   ENSP00000419256  

    LRCH1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for LRCH1
    OriGene Custom MassSpec
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    Novus Biologicals LRCH1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRCH1

     
    Search eBioscience for Proteins for LRCH1 

    LRCH1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals LRCH1 Antibody
    Abcam antibodies for LRCH1
    Cloud-Clone Corp. Antibodies for LRCH1
    Search ThermoFisher Antibodies for LRCH1
    LSBio Antibodies in human, mouse, rat for LRCH1

    LRCH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LRCH1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRCH1
    Cloud-Clone Corp. CLIAs for LRCH1
    Search eBioscience for ELISAs for LRCH1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001715 CH-domain
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q9Y2L9

    ProtoNet protein and cluster: Q9Y2L9

    1 Blocks protein domain: IPB001715 Calponin-like actin-binding

    UniProtKB/Swiss-Prot: LRCH1_HUMAN, Q9Y2L9
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 9 LRR (leucine-rich) repeats


    Find genes that share domains with LRCH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRCH1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRCH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRCH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRCH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRCH1

    miRNA
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    Block miRNA regulation of human, mouse, rat LRCH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRCH1 (see all 100):
    hsa-miR-3152-3p hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p hsa-miR-192* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidLRCH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRCH1
    Predesigned siRNA for gene silencing in human, mouse, rat LRCH1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRCH1

    Clone
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    OriGene clones in human, mouse for LRCH1 (see all 17)
    OriGene ORF clones in mouse, rat for LRCH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LRCH1 (NM_015116)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRCH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRCH1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for LRCH1
    Browse ESI BIO Cell Lines and PureStem Progenitors for LRCH1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRCH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRCH1
    Interactions:

        Search GeneGlobe Interaction Network for LRCH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for LRCH1 (Q9Y2L93 ENSP000003744484) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840223, ENSP000003329734I2D: score=1 STRING: ENSP00000332973
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    UBCENSP000003448184STRING: ENSP00000344818
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRCH1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRCH1 gene (3 alternative transcripts): 
    NM_001164211.1  NM_001164213.1  NM_015116.2  

    Unigene Cluster for LRCH1:

    Leucine-rich repeats and calponin homology (CH) domain containing 1
    Hs.507971  [show with all ESTs]
    Unigene Representative Sequence: NM_001164211
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311191(uc001vbl.4) ENST00000443945(uc010acp.2) ENST00000389798(uc001vbk.3 uc001vbj.3)
    ENST00000389797 ENST00000463929 ENST00000478412
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRCH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRCH1 (see all 100):
    hsa-miR-3152-3p hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-3613-3p hsa-miR-192* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidLRCH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRCH1
    Predesigned siRNA for gene silencing in human, mouse, rat LRCH1
    Clone
    Products:
         
    OriGene clones in human, mouse for LRCH1 (see all 17)
    OriGene ORF clones in mouse, rat for LRCH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): LRCH1 (NM_015116)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRCH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRCH1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LRCH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRCH1
      QuantiTect SYBR Green Assays in human, mouse, rat LRCH1
      QuantiFast Probe-based Assays in human, mouse, rat LRCH1

    Additional mRNA sequence: 

    AB023233.1 AK292898.1 AK309937.1 AY050631.1 AY050632.1 BC026097.1 BC112937.1 BC117472.1 
    BC143883.1 

    8 DOTS entries:

    DT.443266  DT.99984303  DT.428438  DT.95115501  DT.40291208  DT.120761698  DT.120761761  DT.97808141 

    Selected AceView cDNA sequences (see all 94):

    BF328431 BQ709919 AI094735 AW105617 BM991796 AI188546 AA579863 BQ421909 
    AA278553 AI080462 BE018226 CD514335 AA011538 AI628341 AI308154 AI038371 
    BE551517 AI245862 BE044078 AI969570 AA251355 AA443048 BU617009 BI769606 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRCH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTACCCC
    LRCH1 Expression
    About this image

    LRCH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRCH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507971
        Custom PCR Arrays for LRCH1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LRCH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRCH1
    QuantiTect SYBR Green Assays in human, mouse, rat LRCH1
    QuantiFast Probe-based Assays in human, mouse, rat LRCH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRCH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRCH1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrch11 , 5 leucine-rich repeats and calponin homology (CH) domain more1, 5 82.43(n)1
    83.75(a)1
      14 (39.39 cM)5
    3809161  NM_001033439.31  NP_001028611.21 
     747546745 
    chicken
    (Gallus gallus)
    Aves LRCH16
    leucine-rich repeats and calponin homology (CH) do...
    77(a)
    1 ↔ 1
    1(167496661-167608713)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.196252 Xenopus laevis transcribed sequence with weak similarity more 77.72(n)    BX843582.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-260b17.81 si:ch211-260b17.8 62.44(n)
    62.74(a)
      560885  XM_005167641.1  XP_005167698.1 


    ENSEMBL Gene Tree for LRCH1 (if available)
    TreeFam Gene Tree for LRCH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRCH1 gene
    LRRC22  LRCH22  LRRC182  LRSAM12  LRRC302  PIDD2  LRCH32  LRRC572  
    LRRC10B2  LRRC392  LRCH42  LRRC102  
    7 SIMAP similar genes for LRCH1 using alignment to 4 protein entries:     LRCH1_HUMAN (see all proteins):
    LRCH2    LRCH4    LRRD1    LRRC57    LRCH3    LRRC28
    CNN3

    Find genes that share paralogs with LRCH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRCH1 (see all 3962)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383504281,2
    C--27936774(+) TCCTT-/TATTTC 3 -- int10--------
    rs1490312931,2
    C--27943210(+) ATGAA-/TGTG/T
    GTGTGTGTG
    TGTGT
    3 -- int10--------
    rs595827841,2
    C--27943245(+) TGTGT-/G/GTG 
    T
    /GTGTGT
    TGTGG
    6 -- int1 cds10--------
    rs116186791,2
    H--27943246(+) tgtgtG/TGTGGG 3 -- int10--------
    rs116175281,2
    H--27943247(+) gtgtTG/TTGGGG 3 -- int10--------
    rs2011387911,2
    --27950191(+) TTGTT-/GTTTTT 3 -- int10--------
    rs669145191,2
    C--27951466(+) TCTATT/-TTTTT 3 -- int11Minor allele frequency- -:0.00NA 2
    rs106094001,2
    C--27952672(+) CTTTC-/AT/TA 
            
    ACAAC
    3 -- int11NA 2
    rs105681991,2
    C--27952673(+) TTTCATA/-CAACT 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1396028111,2
    C--27956298(+) CTGTC-/TTTTTTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for LRCH1 (47127296 - 47327176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LRCH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747365CNV Deletion23290073
    esv1496328CNV Insertion17803354
    esv988509CNV Insertion20482838
    nsv1026CNV Insertion18451855
    nsv455876CNV Gain19166990
    esv259618OTHER Complex20981092

    Human Gene Mutation Database (HGMD): LRCH1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRCH1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRCH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610368    OMIM disorders: --

    1 disease for LRCH1:    
    About MalaCards
    osteoarthritis

    1 disease from the University of Copenhagen DISEASES database for LRCH1:
    Osteoarthritis

    Find genes that share disorders with LRCH1           About GenesLikeMe

    Genetic Association Database (GAD): LRCH1
    Human Genome Epidemiology (HuGE) Navigator: LRCH1 (4 documents)

    Export disorders for LRCH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRCH1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with LRCH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system. (PubMed id 20237151)1, 4 Zintzaras E....Karachalios T. (Am. J. Epidemiol. 2010)
    3. Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility. (PubMed id 18049793)1, 4 Jiang Q....Ikegawa S. (J. Hum. Genet. 2008)
    4. Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus. (PubMed id 16891653)1, 4 Snelling S....Loughlin J. (Rheumatology (Oxford) 2007)
    5. Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling. (PubMed id 16447229)1, 4 Spector T.D....Braun A. (Arthritis Rheum. 2006)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (Mol. Cell 2012)
    9. Genetic association analysis of LRCH-1 for knee osteoarthritis. (PubMed id 22325041)1 Shin M.H....Kim T.J. (Clin. Exp. Rheumatol. 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23143 HGNC: 20309 AceView: LRCH1 Ensembl:ENSG00000136141 euGenes: HUgn23143
    ECgene: LRCH1 H-InvDB: LRCH1

    (According to HUGE)
    About This Section

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    HUGE: KIAA1016

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRCH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LRCH1 gene:
    Search GeneIP for patents involving LRCH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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