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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LPXN Gene

protein-coding GIFtS: 51
GCID: GC11M058294

leupaxin

Explore 35 diseases affiliated with
LPXN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leupaxin¹
LDPL¹ ²
LDLP³

External Ids:	HGNC: 14061¹	Entrez Gene: 9404²	Ensembl: ENSG00000110031⁷	OMIM: 605390⁵	UniProtKB: O60711³

Export aliases for LPXN gene to outside databases

Previous GC identifers: GC11M060688 GC11M059807 GC11M058545 GC11M058069 GC11M058052 GC11M054641

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LPXN:

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein

family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich

LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by

associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid

cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results

in multiple transcript variants encoding distinct isoforms.(provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: LPXN_HUMAN, O60711

Function: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the

regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell

adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role

as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen

receptor (BCR) signaling

Gene Wiki entry for LPXN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LPXN gene promoter:
FOXC1 HOXA3 c-Ets-1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LPXN promoter sequence

Search SABiosciences Chromatin IP Primers for LPXN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPXN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1 Ensembl cytogenetic band: 11q12.1 HGNC chromosome: 11

LPXN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPXN gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M058294: view genomic region (about GC identifiers)

Start:	58,294,344 bp from pter	End:	58,345,693 bp from pter
Size:	51,350 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LPXN_HUMAN, O60711 (See protein sequence)

Recommended Name: Leupaxin

Size: 386 amino acids; 43332 Da

Subunit: Interacts with PTPN22 (By similarity). Interacts with unphosphorylated ITGA4. Interacts with PTK2B/PYK2,

PTPN12, AR and SRF. Interacts (via LD motif 3) with LYN and the interaction is induced upon B-cell antigen receptor

(BCR) activation. Interacts (via LD motif 3) with PTK2/FAK

Subcellular location: Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region (By similarity).

Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell

membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity

(PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent

gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin

1 PDB 3D structure from and Proteopedia for LPXN:

1X3H (3D)

Secondary accessions: B2R8B4 B4DV71 Q53FW6 Q6FI07

Alternative splicing: 2 isoforms: O60711-1 O60711-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LPXN: NX_O60711

Post-translational modifications:

Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin

stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60711

LPXN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001137467.1 NP_004802.1

ENSEMBL proteins:

ENSP00000437094 ENSP00000378512 ENSP00000431284 ENSP00000461855

Human Recombinant Protein Products for LPXN:

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	Novus Biologicals LPXN Protein Novus Biologicals LPXN Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LPXN

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002102	podosome	IDA	12674328
GO:0005634	nucleus	IDA	18451096
GO:0005737	cytoplasm	IDA	18451096
GO:0005886	plasma membrane	IDA	17640867
GO:0005925	focal adhesion	IDA	--

LPXN for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for LPXN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LPXN for domains About GeneDecksing

2 InterPro domains/families:

IPR017305 Leupaxin

IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry O60711

ProtoNet protein and cluster: O60711

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LPXN_HUMAN, O60711

Domain: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine

phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR

Similarity: Belongs to the paxillin family

Similarity: Contains 4 LIM zinc-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LPXN_HUMAN, O60711

Function: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the

regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell

adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role

as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen

receptor (BCR) signaling

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003712	transcription cofactor activity	IDA	18451096
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IEA	--

LPXN for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LPXN

miRNA Products:		OriGene 3'-UTR Clone (see all 2): LPXN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LPXN
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		SwitchGear 3'UTR luciferase reporter plasmid: LPXN 3' UTR sequence

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LPXN (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LPXN (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPXN

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LPXN

5/21 Interacting proteins for LPXN (O60711^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HOXA1	P49639²^,³	MINT-67951 I2D: score=4
IMP3	Q9NV31²^,³	MINT-67065 I2D: score=4
LIMS1	P48059²^,³	MINT-67081 I2D: score=4
PHF21A	Q96BD5²^,³	MINT-66621 I2D: score=4
POM121	Q96HA1²^,³	MINT-68277 I2D: score=4

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006461	protein complex assembly	TAS	9565592
GO:0007155	cell adhesion	IEA	--
GO:0007162	negative regulation of cell adhesion	IDA	--

LPXN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LPXN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LPXN
4 Novoseek chemical compound relationships for LPXN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cholesterol	67.5	127	19227901 (5), 17078215 (4), 18038584 (3), 9163044 (3) (see all 43)
lipid	56.6	21	1954241 (3), 1910339 (2), 18326222 (1), 15058230 (1) (see all 14)
tyrosine	26.9	20	19917054 (5), 12674328 (3), 17640867 (2), 17329398 (1) (see all 7)
glucose	0	4	16514819 (1), 17078220 (1), 17078221 (1)

Search CenterWatch for drugs/clinical trials and news about LPXN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LPXN gene (2 alternative transcripts):

NM_001143995.1 NM_004811.2

Unigene Cluster for LPXN:

Leupaxin

Hs.125474 [show with all ESTs]

Unigene Representative Sequence: BC034230

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000530561(uc009ymp.3) ENST00000395074(uc001nmw.3) ENST00000528954(uc010rkj.2 uc010rkk.2)

ENST00000528489 ENST00000529915

miRNA Products:		OriGene 3'-UTR Clone (see all 2): LPXN Browse OriGene MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LPXN

Additional cDNA sequence:

AF062075.1 AK223165.1 AK299264.1 AK300955.1 AK301093.1 AK313306.1 BC007490.1 BC019035.2

BC034230.1 CR536531.1

15 DOTS entries:

DT.454094 DT.100700697 DT.120700709 DT.40287002 DT.100739631 DT.100686394 DT.100793970 DT.100793967

DT.431429 DT.120700715 DT.120700716 DT.86853902 DT.95243959 DT.100705274 DT.92448012

24/201 AceView cDNA sequences (see all 201):

AW664971 CA432399 CD366739 CD365101 CR591836 C01310 BG574658 AA381176

BC034230 CR612739 AA447850 CB147059 CD364666 BQ685319 BE669719 BF062592

CD367482 AW513997 CB529279 AA577013 AA358539 AI095214 BQ004131 AA235254

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LPXN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATACCACTTT

About this image

LPXN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LPXN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LPXN

SOURCE GeneReport for Unigene cluster: Hs.125474

UniProtKB/Swiss-Prot: LPXN_HUMAN, O60711

Tissue specificity: Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues

of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in

the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood

lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in

prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression

SABiosciences Custom PCR Arrays for LPXN

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LPXN gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LPXN¹	leupaxin	63.27(n) 58.95(a)		423129 XM_421060.3 XP_421060.3
lizard (Anolis carolinensis)	Reptilia	LPXN⁶	--	62(a)	1 ↔ 1	1(91308920-91318753)
zebrafish (Danio rerio)	Actinopterygii	si:rp71-15d4.1¹	si:rp71-15d4.1	55.37(n) 54.1(a)		560743 XM_684147.5 XP_689239.4
fruit fly (Drosophila melanogaster)	Insecta	Pax³	cytoskeletal anchoring cytoskeletal anchor protein	57(a)		--
worm (Caenorhabditis elegans)	Secernentea	C28H8.6³	LIM domains	50(a)		III(5962097-5964317) --

ENSEMBL Gene Tree for LPXN (if available)
TreeFam Gene Tree for LPXN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LPXN gene

ABLIM3² LIMS1² LIMS3L² FHL5² LDB3² ABLIM2² PDLIM5² ENSG00000257207²

LIMS2² FHL2² ABLIM1² PDLIM7² EPB49² FHL3² FHL1² TGFB1I1²

LIMS3² PXN²

10 SIMAP similar genes for LPXN using alignment to 3 protein entries: LPXN_HUMAN (see all proteins):

PXN TGFB1I1 LHx4 LDB3 CRIP1 LHX4

LHX6 LMO1 LMO3 LIMS1

LPXN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188958649^1,2		--	58293894(+)	`GCTGAA/GGCAGG`	2	--	ds500¹		0	--	--	--	--
rs139263050^1,2		--	58293939(+)	`TCAGCC/TGAGAT`	2	--	ds500¹		0	--	--	--	--
rs5792105^1,2	C	--	58293994(+)	`CTCAG-/AAAAAA`	2	--	ds500¹		2		NA CSA	4
rs113379676^1,2	C	--	58294280(+)	`TTGTAC/AATAGT`	2	--	ds500¹		1		NA	2
rs184818313^1,2		--	58294302(+)	`AACACA/GGGAAG`	2	--	ds500¹		0	--	--	--	--
rs189328190^1,2		--	58294560(+)	`GAGAAA/GATATG`	2	--	ut3¹		0	--	--	--	--
rs74773323^1,2	C	--	58294591(+)	`TGAAAA/GTGGAG`	2	--	ut3¹		2		WA	120
rs180873113^1,2		--	58294659(+)	`GGGACA/GAGATA`	2	--	ut3¹		0	--	--	--	--
rs185755827^1,2		--	58294675(+)	`ACCTAA/GATCTA`	2	--	ut3¹		0	--	--	--	--
rs189348294^1,2		--	58294801(+)	`ATTTGC/TTCATC`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LPXN (58294344 - 58345693 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LPXN
1 Indel: 58528

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LPXN

DNA2.0 Custom Variant and Variant Library Synthesis for LPXN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LPXN for disorders           About GeneDecksing

OMIM gene information: 605390    OMIM disorders: --

20/35 diseases for LPXN (see all 35):    About MalaCards

mast-cell leukemia type 2 diabetes mellitus ischemic heart disease cholelithiasis

pyelonephritis systemic lupus erythematosus chronic pyelonephritis lupus erythematosus

hypercholesterolemia coronary heart disease diabetes mellitus familial hypercholesterolemia

psoriatic arthritis hypertriglyceridemia acute myeloid leukemia myeloid leukemia

insulin resistance hyperlipidemia myocardial infarction rheumatoid arthritis

10 Novoseek disease relationships for LPXN gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dyslipidemia	51.7	4	19227901 (1), 19663192 (1), 15559223 (1)
niddm	51.2	6	10358865 (5)
hyperlipidemia	51.1	1	15164512 (1)
cholelithiasis	39.2	1	15807442 (1)
atherosclerosis	35	4	18590113 (1), 9460596 (1), 18957124 (1), 10358865 (1)
hypercholesterolemia	33.5	1	15807442 (1)
hypertriglyceridemia	19	1	14669600 (1)
hyperinsulinemia	13.9	2	12856565 (2)
essential hypertension	7.75	1	10515029 (1)
influenza	0	1	8091752 (1)

Human Genome Epidemiology (HuGE) Navigator: LPXN (3 documents)

Export disorders for LPXN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LPXN gene, integrated from 9 sources (see all 103):
(articles sorted by number of sources associating them with LPXN)

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Leupaxin is a novel LIM domain protein that forms a complex with PYK2. (PubMed id 9565592)^{1, 2, 3, 9} Lipsky B.P.... Staunton D.E. (1998)
Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. (PubMed id 17329398)^{1, 2, 9} Sahu S.N....Gupta A. (2007)
Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. (PubMed id 12674328)^{1, 2, 9} Gupta A....Hruska K.A. (2003)
Leupaxin negatively regulates B cell receptor signaling. (PubMed id 17640867)^{1, 2, 9} Chew V. and Lam K.P. (2007)
Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells. (PubMed id 18451096)^{1, 2, 9} Kaulfuss S....Burfeind P. (2008)
The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. (PubMed id 18497331)^{1, 2, 9} Sundberg-Smith L.J....Taylor J.M. (2008)
Leupaxin is similar to paxillin in focal adhesion tar geting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading. (PubMed id 20543562)^{1, 2} Chen P.W. and Kroog G.S. (2010)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9404	HGNC: 14061	AceView: LPXN	Ensembl:ENSG00000110031	euGenes: HUgn9404
ECgene: LPXN	H-InvDB: LPXN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LPXN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LPXN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LPXN gene:
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