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Aliases for LPXN Gene

Aliases for LPXN Gene

  • Leupaxin 2 3
  • LDPL 3
  • LDLP 4

External Ids for LPXN Gene

Previous GeneCards Identifiers for LPXN Gene

  • GC11M060688
  • GC11M059807
  • GC11M058069
  • GC11M058052
  • GC11M058294
  • GC11M054641

Summaries for LPXN Gene

Entrez Gene Summary for LPXN Gene

  • The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

GeneCards Summary for LPXN Gene

LPXN (Leupaxin) is a Protein Coding gene. Diseases associated with LPXN include hypercholesterolemia, familial and diabetes mellitus, noninsulin-dependent. GO annotations related to this gene include transcription cofactor activity. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for LPXN Gene

  • Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

Gene Wiki entry for LPXN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPXN Gene

Genomics for LPXN Gene

Regulatory Elements for LPXN Gene

Genomic Location for LPXN Gene

Chromosome:
11
Start:
58,526,871 bp from pter
End:
58,578,892 bp from pter
Size:
52,022 bases
Orientation:
Minus strand

Genomic View for LPXN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPXN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPXN Gene

Proteins for LPXN Gene

  • Protein details for LPXN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60711-LPXN_HUMAN
    Recommended name:
    Leupaxin
    Protein Accession:
    O60711
    Secondary Accessions:
    • B2R8B4
    • B4DV71
    • Q53FW6
    • Q6FI07

    Protein attributes for LPXN Gene

    Size:
    386 amino acids
    Molecular mass:
    43332 Da
    Quaternary structure:
    • Interacts with PTPN22 (By similarity). Interacts with unphosphorylated ITGA4. Interacts with PTK2B/PYK2, PTPN12, AR and SRF. Interacts (via LD motif 3) with LYN and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via LD motif 3) with PTK2/FAK.

    Three dimensional structures from OCA and Proteopedia for LPXN Gene

    Alternative splice isoforms for LPXN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPXN Gene

Proteomics data for LPXN Gene at MOPED

Post-translational modifications for LPXN Gene

  • Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72.
  • Ubiquitination at Lys 106, Lys 260, Lys 364, and Lys 382
  • Modification sites at PhosphoSitePlus

Other Protein References for LPXN Gene

No data available for DME Specific Peptides for LPXN Gene

Domains & Families for LPXN Gene

Protein Domains for LPXN Gene

Suggested Antigen Peptide Sequences for LPXN Gene

Graphical View of Domain Structure for InterPro Entry

O60711

UniProtKB/Swiss-Prot:

LPXN_HUMAN :
  • The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR
  • Belongs to the paxillin family.
Domain:
  • The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR
  • Contains 4 LIM zinc-binding domains.
Family:
  • Belongs to the paxillin family.
genes like me logo Genes that share domains with LPXN: view

No data available for Gene Families for LPXN Gene

Function for LPXN Gene

Molecular function for LPXN Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

Gene Ontology (GO) - Molecular Function for LPXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IDA 18451096
GO:0005515 protein binding IPI 17640867
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LPXN: view

Phenotypes for LPXN Gene

genes like me logo Genes that share phenotypes with LPXN: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPXN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LPXN Gene

Localization for LPXN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPXN Gene

Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPXN Gene COMPARTMENTS Subcellular localization image for LPXN gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for LPXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IDA 12674328
GO:0005634 nucleus IDA 18451096
GO:0005737 cytoplasm IDA 17640867
GO:0005886 plasma membrane IDA 17640867
GO:0005925 focal adhesion IDA 18451096
genes like me logo Genes that share ontologies with LPXN: view

Pathways & Interactions for LPXN Gene

SuperPathways for LPXN Gene

No Data Available

Gene Ontology (GO) - Biological Process for LPXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006461 protein complex assembly TAS 9565592
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion IDA 20543562
genes like me logo Genes that share ontologies with LPXN: view

No data available for Pathways by source and SIGNOR curated interactions for LPXN Gene

Drugs & Compounds for LPXN Gene

(2) Drugs for LPXN Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholesterol Experimental Pharma Agonist 0
tyrosine Nutra 547

(2) Additional Compounds for LPXN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glucose
LIPID
genes like me logo Genes that share compounds with LPXN: view

Transcripts for LPXN Gene

Unigene Clusters for LPXN Gene

Leupaxin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPXN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPXN Gene

No ASD Table

Relevant External Links for LPXN Gene

GeneLoc Exon Structure for
LPXN
ECgene alternative splicing isoforms for
LPXN

Expression for LPXN Gene

mRNA expression in normal human tissues for LPXN Gene

mRNA differential expression in normal tissues according to GTEx for LPXN Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for LPXN Gene

This gene is overexpressed in Serum (11.9), NK cells (10.9), Peripheral blood mononuclear cells (10.0), Lymph node (9.4), and CD8 Tcells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LPXN Gene



SOURCE GeneReport for Unigene cluster for LPXN Gene Hs.125474

mRNA Expression by UniProt/SwissProt for LPXN Gene

O60711-LPXN_HUMAN
Tissue specificity: Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression.
genes like me logo Genes that share expression patterns with LPXN: view

Protein tissue co-expression partners for LPXN Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for LPXN Gene

This gene was present in the common ancestor of animals.

Orthologs for LPXN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPXN 35
  • 84.18 (n)
  • 84.99 (a)
LPXN 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPXN 35
  • 89.93 (n)
  • 87.97 (a)
LPXN 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpxn 35
  • 87.02 (n)
  • 85.53 (a)
Lpxn 16
Lpxn 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPXN 35
  • 99.74 (n)
  • 99.23 (a)
LPXN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpxn 35
  • 87.11 (n)
  • 85.79 (a)
oppossum
(Monodelphis domestica)
Mammalia LPXN 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPXN 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPXN 35
  • 62.5 (n)
  • 58.15 (a)
LPXN 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPXN 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LPXN 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pax 37
  • 57 (a)
Pax 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C28H8.6 37
  • 50 (a)
pxl-1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9134 36
  • 40 (a)
OneToMany
Species with no ortholog for LPXN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LPXN Gene

ENSEMBL:
Gene Tree for LPXN (if available)
TreeFam:
Gene Tree for LPXN (if available)

Paralogs for LPXN Gene

(8) SIMAP similar genes for LPXN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LPXN: view

Variants for LPXN Gene

Sequence variations from dbSNP and Humsavar for LPXN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs638952 -- 58,576,064(-) AATTT(G/T)GCAAA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs954554 -- 58,547,281(+) CACTA(G/T)GAGGG intron-variant
rs956658 -- 58,547,361(+) ATAGC(C/T)AGTCA intron-variant
rs1047979 -- 58,551,146(-) GGTCT(C/G)GAGCA synonymous-codon, reference
rs1802347 -- 58,550,126(-) GGGCA(A/G)TCATG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for LPXN Gene

Variant ID Type Subtype PubMed ID
nsv820292 CNV Gain 19587683
nsv528190 CNV Loss 19592680

Variation tolerance for LPXN Gene

Residual Variation Intolerance Score: 71.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPXN Gene

HapMap Linkage Disequilibrium report
LPXN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPXN Gene

Disorders for LPXN Gene

MalaCards: The human disease database

(3) MalaCards diseases for LPXN Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
hypercholesterolemia, familial
  • hypercholesterolemia, familial, modifier of
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
hypertension, essential
  • hypertension, essential 3
- elite association
Search LPXN in MalaCards View complete list of genes associated with diseases

Relevant External Links for LPXN

Genetic Association Database (GAD)
LPXN
Human Genome Epidemiology (HuGE) Navigator
LPXN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPXN
genes like me logo Genes that share disorders with LPXN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPXN Gene

Publications for LPXN Gene

  1. Leupaxin is a novel LIM domain protein that forms a complex with PYK2. (PMID: 9565592) Lipsky B.P. … Staunton D.E. (J. Biol. Chem. 1998) 2 23 67
  2. LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin. (PMID: 19917054) Tanaka T. … Miyasaka M. (Cancer Sci. 2010) 23 67
  3. Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitro. (PMID: 18814281) Eskandarpour M. … Hansson J. (Int. J. Cancer 2009) 23 67
  4. Pilot workload during approaches: comparison of simulated standard and noise-abatement profiles. (PMID: 19378906) Elmenhorst E.M. … Basner M. (Aviat Space Environ Med 2009) 23 67
  5. Leupaxin acts as a mediator in prostate carcinoma progression through deregulation of p120catenin expression. (PMID: 19701244) Kaulfuss S. … Burfeind P. (Oncogene 2009) 23 67

Products for LPXN Gene

Sources for LPXN Gene

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