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LPXN Gene

protein-coding   GIFtS: 53
GCID: GC11M058294

Leupaxin

  See LPXN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
leupaxin1 2
LDPL2
LDLP3

External Ids:    HGNC: 140611   Entrez Gene: 94042   Ensembl: ENSG000001100317   OMIM: 6053905   UniProtKB: O607113   

Export aliases for LPXN gene to outside databases

Previous GC identifers: GC11M060688 GC11M059807 GC11M058545 GC11M058069 GC11M058052 GC11M054641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LPXN Gene:
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin
protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four
leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell
type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a
tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase
activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.(provided by
RefSeq, Jan 2009)

GeneCards Summary for LPXN Gene:
LPXN (leupaxin) is a protein-coding gene. Diseases associated with LPXN include chronic pyelonephritis, and familial hypercholesterolemia. GO annotations related to this gene include transcription cofactor activity. An important paralog of this gene is LIMS1.

UniProtKB/Swiss-Prot: LPXN_HUMAN, O60711
Function: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to
the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in
integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin
(PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts.
Negatively regulates B-cell antigen receptor (BCR) signaling

Gene Wiki entry for LPXN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LPXN gene promoter:
         FOXC1   HOXA3   c-Ets-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPXN promoter sequence
   Search Chromatin IP Primers for LPXN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LPXN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

LPXN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPXN gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M058294:  view genomic region     (about GC identifiers)

Start:
58,294,344 bp from pter      End:
58,345,693 bp from pter
Size:
51,350 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LPXN_HUMAN, O60711 (See protein sequence)
Recommended Name: Leupaxin  
Size: 386 amino acids; 43332 Da
Subunit: Interacts with PTPN22 (By similarity). Interacts with unphosphorylated ITGA4. Interacts with PTK2B/PYK2,
PTPN12, AR and SRF. Interacts (via LD motif 3) with LYN and the interaction is induced upon B-cell antigen
receptor (BCR) activation. Interacts (via LD motif 3) with PTK2/FAK
1 PDB 3D structure from and Proteopedia for LPXN:
1X3H (3D)    
Secondary accessions: B2R8B4 B4DV71 Q53FW6 Q6FI07
Alternative splicing: 2 isoforms:  O60711-1   O60711-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LPXN: NX_O60711

Explore proteomics data for LPXN at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin
    stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-721
  • Ubiquitination2 at Lys106, Lys260, Lys364, Lys382
  • Modification sites at PhosphoSitePlus

  • See LPXN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137467.1  NP_004802.1  

    ENSEMBL proteins: 
     ENSP00000437094   ENSP00000378512   ENSP00000431284   ENSP00000461855  

    LPXN Human Recombinant Protein Products:

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    Novus Biologicals LPXN Protein
    Novus Biologicals LPXN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LPXN

     
    Search eBioscience for Proteins for LPXN 

     
    antibodies-online proteins for LPXN (3 products) 

     
    antibodies-online peptides for LPXN

    LPXN Antibody Products:

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    antibodies-online antibodies for LPXN (25 products) 

    LPXN Assay Products:

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    antibodies-online kits for LPXN (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017305 Tgfb1i1/Leupaxin
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry O60711

    ProtoNet protein and cluster: O60711

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LPXN_HUMAN, O60711
    Domain: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine
    phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR
    Similarity: Belongs to the paxillin family
    Similarity: Contains 4 LIM zinc-binding domains


    Find genes that share domains with LPXN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPXN_HUMAN, O60711
    Function: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to
    the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in
    integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin
    (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts.
    Negatively regulates B-cell antigen receptor (BCR) signaling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity IDA18451096
    GO:0005515protein binding IPI17640867
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with LPXN           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LPXN

    miRNA
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    miRTarBase miRNAs that target LPXN:
    hsa-mir-9-5p (MIRT021415)

    Block miRNA regulation of human, mouse, rat LPXN using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LPXN
    SwitchGear 3'UTR luciferase reporter plasmidLPXN 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat LPXN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): LPXN (NM_004811)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPXN

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LPXN_HUMAN, O60711: Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region (By
    similarity). Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited
    to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion
    kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response
    factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine
    phosphorylation in response to bombesin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002102podosome IDA12674328
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA17640867
    GO:0005925focal adhesion IDA18451096

    Find genes that share ontologies with LPXN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LPXN
    Interactions:

        GeneGlobe Interaction Network for LPXN

    Selected Interacting proteins for LPXN (O607111, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXA1P496392, 3MINT-67951 I2D: score=4 
    IMP3Q9NV312, 3MINT-67065 I2D: score=4 
    LIMS1P480592, 3MINT-67081 I2D: score=4 
    PHF21AQ96BD52, 3MINT-66621 I2D: score=4 
    POM121Q96HA12, 3MINT-68277 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006461protein complex assembly TAS9565592
    GO:0007155cell adhesion IEA--
    GO:0007162negative regulation of cell adhesion IDA--

    Find genes that share ontologies with LPXN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LPXN

    4 Novoseek inferred chemical compound relationships for LPXN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 67.5 127 19227901 (5), 17078215 (4), 18038584 (3), 9163044 (3) (see all 43)
    lipid 56.6 21 1954241 (3), 1910339 (2), 18326222 (1), 15058230 (1) (see all 14)
    tyrosine 26.9 20 19917054 (5), 12674328 (3), 17640867 (2), 17329398 (1) (see all 7)
    glucose 0 4 16514819 (1), 17078220 (1), 17078221 (1)



    Find genes that share compounds with LPXN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LPXN gene (2 alternative transcripts): 
    NM_001143995.1  NM_004811.2  

    Unigene Cluster for LPXN:

    Leupaxin
    Hs.125474  [show with all ESTs]
    Unigene Representative Sequence: BC034230
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530561(uc009ymp.3) ENST00000395074(uc001nmw.3) ENST00000528954(uc010rkj.2 uc010rkk.2)
    ENST00000528489 ENST00000529915
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LPXN
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      QuantiTect SYBR Green Assays in human, mouse, rat LPXN
      QuantiFast Probe-based Assays in human, mouse, rat LPXN

    Additional mRNA sequence: 

    AF062075.1 AK223165.1 AK299264.1 AK300955.1 AK301093.1 AK313306.1 BC007490.1 BC019035.2 
    BC034230.1 CR536531.1 

    15 DOTS entries:

    DT.454094  DT.100700697  DT.120700709  DT.40287002  DT.100739631  DT.100686394  DT.100793970  DT.100793967 
    DT.431429  DT.120700715  DT.120700716  DT.86853902  DT.95243959  DT.100705274  DT.92448012 

    Selected AceView cDNA sequences (see all 201):

    AA577013 BM456256 BG574658 BX090225 BU633191 AW664971 AI347580 BC019035 
    BQ004131 CB529279 BC034230 CA487518 CD367482 BU688891 AA962522 AA358539 
    BQ685319 H25474 CD366739 AA381176 AA235254 AI095214 AA447850 CR612739 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LPXN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACCACTTT
    LPXN Expression
    About this image


    LPXN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Tonsil (Hematopoietic System)
    LPXN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LPXN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125474

    UniProtKB/Swiss-Prot: LPXN_HUMAN, O60711
    Tissue specificity: Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and
    tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and
    appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in
    peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell
    lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa
    progression

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LPXN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lpxn1 , 5 leupaxin1, 5 87.02(n)1
    85.53(a)1
      19 (8.73 cM)5
    1073211  NM_134152.31  NP_598913.11 
     127986095 
    chicken
    (Gallus gallus)
    Aves LPXN1 leupaxin 62.5(n)
    58.15(a)
      423129  XM_421060.4  XP_421060.4 
    lizard
    (Anolis carolinensis)
    Reptilia LPXN6
    leupaxin
    60(a)
    1 ↔ 1
    1(91302270-91320736)
    zebrafish
    (Danio rerio)
    Actinopterygii LPXN6
    leupaxin
    45(a)
    1 ↔ 1
    8(20486624-20515106) ENSDARG00000079315
    fruit fly
    (Drosophila melanogaster)
    Insecta Pax3 cytoskeletal anchoring cytoskeletal
    anchor protein
    57(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C28H8.63 LIM domains 50(a)   III(5962097-5964317)   --


    ENSEMBL Gene Tree for LPXN (if available)
    TreeFam Gene Tree for LPXN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LPXN gene
    LIMS12  PDLIM72  LIMS3L2  FHL32  FHL52  LDB32  FHL12  ENSG000002572072  
    LIMS32  TGFB1I12  PDLIM52  PXN2  FHL22  LIMS22  
    8 SIMAP similar genes for LPXN using alignment to 3 protein entries:     LPXN_HUMAN (see all proteins):
    PXN    TGFB1I1    LHx4    CRIP1    LHX4    LMO1
    LMO3    LIMS1

    Find genes that share paralogs with LPXN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LPXN (see all 950)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889586491,2
    --58293894(+) GCTGAA/GGCAGG 2 -- ds50010--------
    rs1392630501,2
    --58293939(+) TCAGCC/TGAGAT 2 -- ds50010--------
    rs57921051,2
    C--58293994(+) CTCAG-/AAAAAA 2 -- ds50012Minor allele frequency- A:0.00NA CSA 4
    rs1133796761,2
    C,F--58294280(+) TTGTAC/AATAGT 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1848183131,2
    --58294302(+) AACACA/GGGAAG 2 -- ds50010--------
    rs1893281901,2
    --58294560(+) GAGAAA/GATATG 2 -- ut310--------
    rs747733231,2
    C--58294591(+) TGAAAA/GTGGAG 2 -- ut312Minor allele frequency- G:0.06WA 120
    rs1808731131,2
    --58294659(+) GGGACA/GAGATA 2 -- ut310--------
    rs1857558271,2
    --58294675(+) ACCTAA/GATCTA 2 -- ut310--------
    rs1893482941,2
    C--58294801(+) ATTTGC/TTCATC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LPXN (58294344 - 58345693 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LPXN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528190CNV Loss19592680
    nsv820292CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605390    OMIM disorders: --

    2 diseases for LPXN:    
    About MalaCards
    chronic pyelonephritis    familial hypercholesterolemia


    Find genes that share disorders with LPXN           About GenesLikeMe

    10 Novoseek inferred disease relationships for LPXN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dyslipidemia 51.7 4 19227901 (1), 19663192 (1), 15559223 (1)
    niddm 51.2 6 10358865 (5)
    hyperlipidemia 51.1 1 15164512 (1)
    cholelithiasis 39.2 1 15807442 (1)
    atherosclerosis 35 4 18590113 (1), 9460596 (1), 18957124 (1), 10358865 (1)
    hypercholesterolemia 33.5 1 15807442 (1)
    hypertriglyceridemia 19 1 14669600 (1)
    hyperinsulinemia 13.9 2 12856565 (2)
    essential hypertension 7.75 1 10515029 (1)
    influenza 0 1 8091752 (1)

    Genetic Association Database (GAD): LPXN
    Human Genome Epidemiology (HuGE) Navigator: LPXN (3 documents)

    Export disorders for LPXN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LPXN gene, integrated from 10 sources (see all 108):
    (articles sorted by number of sources associating them with LPXN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Leupaxin is a novel LIM domain protein that forms a complex with PYK2. (PubMed id 9565592)1, 2, 3, 9 Lipsky B.P.... Staunton D.E. (J. Biol. Chem. 1998)
    2. Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. (PubMed id 17329398)1, 2, 9 Sahu S.N.... Gupta A. (Am. J. Physiol. 2007)
    3. Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. (PubMed id 12674328)1, 2, 9 Gupta A.... Hruska K.A. (J. Bone Miner. Res. 2003)
    4. Leupaxin negatively regulates B cell receptor signaling. (PubMed id 17640867)1, 2, 9 Chew V. and Lam K.P. (J. Biol. Chem. 2007)
    5. Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells. (PubMed id 18451096)1, 2, 9 Kaulfuss S.... Burfeind P. (Mol. Endocrinol. 2008)
    6. The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. (PubMed id 18497331)1, 2, 9 Sundberg-Smith L.J....Taylor J.M. (Circ. Res. 2008)
    7. Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading. (PubMed id 20543562)1, 2 Chen P.W. and Kroog G.S. (Cell Adh. Migr. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    10. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9404 HGNC: 14061 AceView: LPXN Ensembl:ENSG00000110031 euGenes: HUgn9404
    ECgene: LPXN H-InvDB: LPXN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LPXN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LPXN gene:
    Search GeneIP for patents involving LPXN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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