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Aliases for LPXN Gene

Aliases for LPXN Gene

  • Leupaxin 2 3
  • LDPL 3
  • LDLP 4

External Ids for LPXN Gene

Summaries for LPXN Gene

Entrez Gene Summary for LPXN Gene

  • The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

GeneCards Summary for LPXN Gene

LPXN (Leupaxin) is a Protein Coding gene. Diseases associated with LPXN include chronic pyelonephritis. GO annotations related to this gene include transcription cofactor activity. An important paralog of this gene is LDB3.

UniProtKB/Swiss-Prot for LPXN Gene

  • Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

Gene Wiki entry for LPXN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPXN Gene

Genomics for LPXN Gene

Genomic Location for LPXN Gene

Start:
58,526,871 bp from pter
End:
58,578,239 bp from pter
Size:
51,369 bases
Orientation:
Minus strand

Genomic View for LPXN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPXN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPXN Gene

Regulatory Elements for LPXN Gene

Proteins for LPXN Gene

  • Protein details for LPXN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60711-LPXN_HUMAN
    Recommended name:
    Leupaxin
    Protein Accession:
    O60711
    Secondary Accessions:
    • B2R8B4
    • B4DV71
    • Q53FW6
    • Q6FI07

    Protein attributes for LPXN Gene

    Size:
    386 amino acids
    Molecular mass:
    43332 Da
    Quaternary structure:
    • Interacts with PTPN22 (By similarity). Interacts with unphosphorylated ITGA4. Interacts with PTK2B/PYK2, PTPN12, AR and SRF. Interacts (via LD motif 3) with LYN and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via LD motif 3) with PTK2/FAK.

    Three dimensional structures from OCA and Proteopedia for LPXN Gene

    Alternative splice isoforms for LPXN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPXN Gene

Proteomics data for LPXN Gene at MOPED

Post-translational modifications for LPXN Gene

  • Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys106, Lys260, Lys364, and Lys382

Other Protein References for LPXN Gene

No data available for DME Specific Peptides for LPXN Gene

Domains for LPXN Gene

Protein Domains for LPXN Gene

UniProtKB/Swiss-Prot:

LPXN_HUMAN
Domain:
  • The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR:
    • O60711
  • Contains 4 LIM zinc-binding domains.:
    • O60711
Family:
  • Belongs to the paxillin family.:
    • O60711
genes like me logo Genes that share domains with LPXN: view

No data available for Gene Families for LPXN Gene

Function for LPXN Gene

Molecular function for LPXN Gene

UniProtKB/Swiss-Prot Function: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

Gene Ontology (GO) - Molecular Function for LPXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IDA 18451096
GO:0005515 protein binding IPI 17640867
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LPXN: view

miRNA for LPXN Gene

miRTarBase miRNAs that target LPXN

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LPXN Gene

Localization for LPXN Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPXN Gene

Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPXN Gene COMPARTMENTS Subcellular localization image for LPXN gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for LPXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IDA 12674328
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA 17640867
GO:0005925 focal adhesion IDA 18451096
genes like me logo Genes that share ontologies with LPXN: view

Pathways for LPXN Gene

SuperPathways for LPXN Gene

No Data Available

Gene Ontology (GO) - Biological Process for LPXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006461 protein complex assembly TAS 9565592
GO:0007155 cell adhesion IEA --
GO:0007162 negative regulation of cell adhesion IDA 20543562
genes like me logo Genes that share ontologies with LPXN: view

No data available for Pathways by source for LPXN Gene

Compounds for LPXN Gene

(4) Novoseek inferred chemical compound relationships for LPXN Gene

Compound -log(P) Hits PubMed IDs
cholesterol 67.5 65
lipid 56.6 17
tyrosine 26.9 14
glucose 0 3
genes like me logo Genes that share compounds with LPXN: view

Transcripts for LPXN Gene

Unigene Clusters for LPXN Gene

Leupaxin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPXN Gene

No ASD Table

Relevant External Links for LPXN Gene

GeneLoc Exon Structure for
LPXN
ECgene alternative splicing isoforms for
LPXN

Expression for LPXN Gene

mRNA expression in normal human tissues for LPXN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPXN Gene

This gene is overexpressed in Whole Blood (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LPXN Gene

SOURCE GeneReport for Unigene cluster for LPXN Gene Hs.125474

mRNA Expression by UniProt/SwissProt for LPXN Gene

O60711-LPXN_HUMAN
Tissue specificity: Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression.
genes like me logo Genes that share expressions with LPXN: view

Orthologs for LPXN Gene

This gene was present in the common ancestor of animals.

Orthologs for LPXN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPXN 36
  • 99.74 (n)
  • 99.23 (a)
LPXN 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPXN 36
  • 84.18 (n)
  • 84.99 (a)
LPXN 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPXN 36
  • 89.93 (n)
  • 87.97 (a)
LPXN 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpxn 36
  • 87.02 (n)
  • 85.53 (a)
Lpxn 16
Lpxn 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPXN 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPXN 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpxn 36
  • 87.11 (n)
  • 85.79 (a)
chicken
(Gallus gallus)
Aves LPXN 36
  • 62.5 (n)
  • 58.15 (a)
LPXN 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPXN 37
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LPXN 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pax 37
  • 33 (a)
OneToMany
Pax 38
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea pxl-1 37
  • 35 (a)
OneToMany
C28H8.6 38
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9134 37
  • 40 (a)
OneToMany
Species with no ortholog for LPXN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LPXN Gene

ENSEMBL:
Gene Tree for LPXN (if available)
TreeFam:
Gene Tree for LPXN (if available)

Paralogs for LPXN Gene

Selected SIMAP similar genes for LPXN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LPXN: view

Variants for LPXN Gene

Sequence variations from dbSNP and Humsavar for LPXN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs638952 -- 58,576,064(-) AATTT(G/T)GCAAA intron-variant, upstream-variant-2KB
rs954554 -- 58,547,281(+) CACTA(G/T)GAGGG intron-variant
rs956658 -- 58,547,361(+) ATAGC(C/T)AGTCA intron-variant
rs1047979 -- 58,551,146(-) GGTCT(C/G)GAGCA synonymous-codon, reference
rs1802347 -- 58,550,126(-) GGGCA(A/G)TCATG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for LPXN Gene

Variant ID Type Subtype PubMed ID
nsv820292 CNV Gain 19587683
nsv528190 CNV Loss 19592680

Relevant External Links for LPXN Gene

HapMap Linkage Disequilibrium report
LPXN

Disorders for LPXN Gene

(1) MalaCards Diseases for LPXN Gene

Search for LPXN Gene in MalaCards »

(10) Novoseek inferred disease relationships for LPXN Gene

Disease -log(P) Hits PubMed IDs
dyslipidemia 51.7 3
niddm 51.2 5
hyperlipidemia 51.1 1
cholelithiasis 39.2 1
atherosclerosis 35 4

Relevant External Links for LPXN

Genetic Association Database (GAD)
LPXN
Human Genome Epidemiology (HuGE) Navigator
LPXN
genes like me logo Genes that share disorders with LPXN: view

No data available for UniProtKB/Swiss-Prot for LPXN Gene

Publications for LPXN Gene

  1. Leupaxin is a novel LIM domain protein that forms a complex with PYK2. (PMID: 9565592) Lipsky B.P. … Staunton D.E. (J. Biol. Chem. 1998) 2 3 4 23
  2. Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. (PMID: 12674328) Gupta A. … Hruska K.A. (J. Bone Miner. Res. 2003) 3 4 23
  3. Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells. (PMID: 18451096) Kaulfuss S. … Burfeind P. (Mol. Endocrinol. 2008) 3 4 23
  4. The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. (PMID: 18497331) Sundberg-Smith L.J. … Taylor J.M. (Circ. Res. 2008) 3 4 23
  5. Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. (PMID: 17329398) Sahu S.N. … Gupta A. (Am. J. Physiol. 2007) 3 4 23

Products for LPXN Gene

Sources for LPXN Gene

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