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Aliases for LPP Gene

Aliases for LPP Gene

  • LIM Domain Containing Preferred Translocation Partner In Lipoma 2 3 5
  • LIM Domain-Containing Preferred Translocation Partner In Lipoma 2 4
  • Lipoma Preferred Partner Gene 2

External Ids for LPP Gene

Previous GeneCards Identifiers for LPP Gene

  • GC03P184748
  • GC03P189132
  • GC03P189272
  • GC03P189191
  • GC03P189251
  • GC03P189413
  • GC03P187871
  • GC03P185276

Summaries for LPP Gene

Entrez Gene Summary for LPP Gene

  • This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for LPP Gene

LPP (LIM Domain Containing Preferred Translocation Partner In Lipoma) is a Protein Coding gene. Diseases associated with LPP include Leukemia, Acute Myeloid and Acute Monoblastic Leukemia. Among its related pathways are Stabilization and expansion of the E-cadherin adherens junction and Cytoskeletal Signaling. An important paralog of this gene is TRIP6.

UniProtKB/Swiss-Prot for LPP Gene

  • May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.

Gene Wiki entry for LPP Gene

Additional gene information for LPP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPP Gene

Genomics for LPP Gene

Regulatory Elements for LPP Gene

Enhancers for LPP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H188292 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +143.7 143661 6 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS SP5 ZHX2 LPP FLJ42393 LPP-AS1
GH03H187735 1.8 FANTOM5 ENCODE dbSUPER 11.8 -410.3 -410334 13 MLX DMAP1 YY1 SLC30A9 ZNF143 MEF2D SSRP1 ZNF610 GLIS1 NBN LOC100131635 ENSG00000200418 SNORA4 BCL6 LPP RFC4 SNORA81 ST6GAL1 RTP4 BCL6-AS1
GH03H188260 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +115.6 115556 15 PKNOX1 FOXA2 ATF1 ARNT SIN3A FEZF1 BRCA1 ZNF2 YY1 KLF7 LPP ENSG00000234238 FLJ42393 LPP-AS1
GH03H187748 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -401.7 -401695 3 FOXA2 ATF1 MLX ARID4B SIN3A GLI4 ZNF2 YY1 SP5 NFYC LPP BCL6 LOC105374263
GH03H188184 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +33.7 33740 3 ELF3 PKNOX1 FOXA2 MLX ARID4B FEZF1 ZSCAN9 RAD21 RARA YY1 ENSG00000234238 LPP BCL6 FLJ42393 LPP-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LPP on UCSC Golden Path with GeneCards custom track

Genomic Location for LPP Gene

Chromosome:
3
Start:
188,152,143 bp from pter
End:
188,890,671 bp from pter
Size:
738,529 bases
Orientation:
Plus strand

Genomic View for LPP Gene

Genes around LPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPP Gene

Proteins for LPP Gene

  • Protein details for LPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93052-LPP_HUMAN
    Recommended name:
    Lipoma-preferred partner
    Protein Accession:
    Q93052
    Secondary Accessions:
    • A1L4L6
    • D3DNV6
    • Q8NFX5

    Protein attributes for LPP Gene

    Size:
    612 amino acids
    Molecular mass:
    65746 Da
    Quaternary structure:
    • Interacts with VASP, with PDZ domains of SCRIB and with ACTN1/alpha-actinin.

neXtProt entry for LPP Gene

Post-translational modifications for LPP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LPP Gene

Domains & Families for LPP Gene

Gene Families for LPP Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for LPP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LPP Gene

Graphical View of Domain Structure for InterPro Entry

Q93052

UniProtKB/Swiss-Prot:

LPP_HUMAN :
  • Belongs to the zyxin/ajuba family.
Family:
  • Belongs to the zyxin/ajuba family.
genes like me logo Genes that share domains with LPP: view

Function for LPP Gene

Molecular function for LPP Gene

GENATLAS Biochemistry:
lipoma preferred fusion partner of HMGIC,LIM protein gene family,group 3
UniProtKB/Swiss-Prot Function:
May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.

Phenotypes From GWAS Catalog for LPP Gene

Gene Ontology (GO) - Molecular Function for LPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15649318
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LPP: view
genes like me logo Genes that share phenotypes with LPP: view

Animal Models for LPP Gene

MGI Knock Outs for LPP:

Animal Model Products

CRISPR Products

miRNA for LPP Gene

miRTarBase miRNAs that target LPP

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LPP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPP Gene

Localization for LPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPP Gene

Nucleus. Cytoplasm. Cell junction. Cell membrane. Note=Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and KMT2A/MLL1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPP gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Focal adhesion sites (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with LPP: view

Pathways & Interactions for LPP Gene

genes like me logo Genes that share pathways with LPP: view

Pathways by source for LPP Gene

1 Cell Signaling Technology pathway for LPP Gene

Interacting Proteins for LPP Gene

SIGNOR curated interactions for LPP Gene

Is activated by:

Gene Ontology (GO) - Biological Process for LPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LPP: view

Drugs & Compounds for LPP Gene

(5) Drugs for LPP Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma 2226
Anti-Infective Agents Pharma 22631
Anti-Infective Agents, Local Pharma 1960
Central Nervous System Depressants Pharma 13909

(1) Additional Compounds for LPP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LPP: view

Transcripts for LPP Gene

Unigene Clusters for LPP Gene

LIM domain containing preferred translocation partner in lipoma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LPP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LPP Gene

No ASD Table

Relevant External Links for LPP Gene

GeneLoc Exon Structure for
LPP
ECgene alternative splicing isoforms for
LPP

Expression for LPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPP Gene

This gene is overexpressed in Artery - Tibial (x6.6) and Esophagus - Muscularis (x4.9).

Protein differential expression in normal tissues from HIPED for LPP Gene

This gene is overexpressed in Uterus (15.0), Urinary Bladder (11.7), Prostate (8.2), Rectum (7.0), and Cardia (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LPP Gene



Protein tissue co-expression partners for LPP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LPP Gene:

LPP

SOURCE GeneReport for Unigene cluster for LPP Gene:

Hs.720220

mRNA Expression by UniProt/SwissProt for LPP Gene:

Q93052-LPP_HUMAN
Tissue specificity: Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.

Evidence on tissue expression from TISSUES for LPP Gene

  • Intestine(4.6)
  • Liver(4.3)
  • Nervous system(4.1)
  • Skin(3.1)
  • Lung(2.5)
  • Heart(2.2)
  • Muscle(2.2)
  • Blood(2.1)
  • Gall bladder(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LPP Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Organs:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with LPP: view

Primer Products

Orthologs for LPP Gene

This gene was present in the common ancestor of animals.

Orthologs for LPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPP 33 34
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia LPP 33 34
  • 89.54 (n)
dog
(Canis familiaris)
Mammalia LPP 33 34
  • 88.94 (n)
mouse
(Mus musculus)
Mammalia Lpp 16 34 33
  • 85.73 (n)
rat
(Rattus norvegicus)
Mammalia Lpp 33
  • 84.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LPP 34
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPP 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPP 34 33
  • 74.23 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPP 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpp 33
  • 74.82 (n)
zebrafish
(Danio rerio)
Actinopterygii lpp 34 33
  • 68.91 (n)
OneToOne
zgc56152 33
fruit fly
(Drosophila melanogaster)
Insecta Zyx102EF 35
  • 62 (a)
Zyx 34
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zyx-1 35
  • 52 (a)
Species where no ortholog for LPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LPP Gene

ENSEMBL:
Gene Tree for LPP (if available)
TreeFam:
Gene Tree for LPP (if available)

Paralogs for LPP Gene

Paralogs for LPP Gene

genes like me logo Genes that share paralogs with LPP: view

Variants for LPP Gene

Sequence variations from dbSNP and Humsavar for LPP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000001947 -- 188,719,241(+) ATTTC(A/G)TACCA intron-variant
rs1000003709 -- 188,277,979(+) CCATG(A/G)TTTAG intron-variant
rs1000011864 -- 188,741,007(+) TGGAG(C/G)AGAAA intron-variant
rs1000016848 -- 188,391,271(+) AGTAC(C/T)TCTGG intron-variant
rs1000018903 -- 188,569,239(+) CTTTA(C/T)ATGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LPP Gene

Variant ID Type Subtype PubMed ID
dgv1436e212 CNV loss 25503493
dgv1437e212 CNV loss 25503493
dgv2655n106 CNV deletion 24896259
dgv5006n100 CNV loss 25217958
dgv8778n54 CNV loss 21841781
dgv900e199 CNV deletion 23128226
dgv964e214 CNV gain 21293372
esv1535519 CNV insertion 17803354
esv1727014 CNV deletion 17803354
esv2313176 CNV deletion 18987734
esv2471009 CNV deletion 19546169
esv2506913 CNV deletion 19546169
esv2541501 CNV deletion 19546169
esv2664419 CNV deletion 23128226
esv2669680 CNV deletion 23128226
esv2726356 CNV deletion 23290073
esv2726357 CNV deletion 23290073
esv2751987 CNV gain 17911159
esv2762370 CNV loss 21179565
esv2763328 CNV loss 21179565
esv2763329 CNV gain 21179565
esv33400 CNV gain 17666407
esv34193 CNV loss 18971310
esv3563060 CNV deletion 23714750
esv3569171 CNV loss 25503493
esv3599026 CNV loss 21293372
esv3599028 CNV gain 21293372
esv3599029 CNV gain 21293372
esv3599030 CNV loss 21293372
esv3599032 CNV loss 21293372
esv3599033 CNV loss 21293372
esv3599037 CNV loss 21293372
esv3599039 CNV loss 21293372
esv7339 CNV loss 19470904
nsv1003486 CNV gain 25217958
nsv1010485 CNV loss 25217958
nsv1073271 CNV deletion 25765185
nsv1074648 CNV deletion 25765185
nsv1123722 CNV deletion 24896259
nsv1128010 CNV deletion 24896259
nsv1128011 CNV deletion 24896259
nsv1131747 CNV deletion 24896259
nsv1136791 CNV deletion 24896259
nsv1136792 CNV deletion 24896259
nsv1153167 CNV deletion 26484159
nsv1161013 CNV duplication 26073780
nsv236225 CNV deletion 16902084
nsv4161 CNV insertion 18451855
nsv4162 CNV insertion 18451855
nsv461046 CNV loss 19166990
nsv461047 CNV loss 19166990
nsv513100 CNV loss 21212237
nsv592757 CNV loss 21841781
nsv592758 CNV loss 21841781
nsv592759 CNV loss 21841781
nsv592760 CNV loss 21841781
nsv819096 CNV loss 19587683
nsv822370 CNV loss 20364138
nsv955538 CNV deletion 24416366
nsv955601 CNV deletion 24416366

Variation tolerance for LPP Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.86; 87.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPP Gene

Human Gene Mutation Database (HGMD)
LPP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPP Gene

Disorders for LPP Gene

MalaCards: The human disease database

(18) MalaCards diseases for LPP Gene - From: HGMD, OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
acute monoblastic leukemia
  • acute monocytic leukemia
prostate carcinoma in situ
  • carcinoma in situ of prostate
lipomatosis, multiple
  • lipoma
esophageal atresia/tracheoesophageal fistula
  • esophageal atresia and/or tracheoesophageal fistula
- elite association - COSMIC cancer census association via MalaCards
Search LPP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LPP_HUMAN
  • Note=A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.
  • Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with KMT2A/MLL1 is associated with acute monoblastic leukemia.
  • Note=A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.
  • Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.

Relevant External Links for LPP

Genetic Association Database (GAD)
LPP
Human Genome Epidemiology (HuGE) Navigator
LPP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPP
genes like me logo Genes that share disorders with LPP: view

No data available for Genatlas for LPP Gene

Publications for LPP Gene

  1. The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein. (PMID: 12441356) Petit MM … Van de Ven WJ (The Journal of biological chemistry 2003) 3 4 22 60
  2. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. (PMID: 10637295) Petit MM … Friederich E (Molecular biology of the cell 2000) 3 4 22 60
  3. Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. (PMID: 9772904) Petit MM … Van de Ven WJ (Cancer genetics and cytogenetics 1998) 3 4 22 60
  4. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. (PMID: 8812423) Petit MM … Van de Ven WJ (Genomics 1996) 2 3 4 60
  5. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (PMID: 22075330) Granada M … O'Connor GT (The Journal of allergy and clinical immunology 2012) 3 45 60

Products for LPP Gene

Sources for LPP Gene

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