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Aliases for LPO Gene

Aliases for LPO Gene

  • Lactoperoxidase 2 3
  • Salivary Peroxidase 3 4
  • SPO 3 4
  • EC 1.11.1.7 4
  • EC 1.11.1 63
  • SAPX 4

External Ids for LPO Gene

Previous GeneCards Identifiers for LPO Gene

  • GC17P056060
  • GC17P058797
  • GC17P056658
  • GC17P056790
  • GC17P053670
  • GC17P056315
  • GC17P051676

Summaries for LPO Gene

Entrez Gene Summary for LPO Gene

  • This gene encodes an oxidoreductase secreted from salivary, mammary, and other mucosal glands that functions as a natural antibacterial agent. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for LPO Gene

LPO (Lactoperoxidase) is a Protein Coding gene. Diseases associated with LPO include dental caries and atrophic glossitis. Among its related pathways are Salivary secretion. GO annotations related to this gene include heme binding and thiocyanate peroxidase activity. An important paralog of this gene is MPO.

UniProtKB/Swiss-Prot for LPO Gene

  • Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.

Gene Wiki entry for LPO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPO Gene

Genomics for LPO Gene

Regulatory Elements for LPO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LPO Gene

Chromosome:
17
Start:
58,218,548 bp from pter
End:
58,268,536 bp from pter
Size:
49,989 bases
Orientation:
Plus strand

Genomic View for LPO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPO Gene

Proteins for LPO Gene

  • Protein details for LPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22079-PERL_HUMAN
    Recommended name:
    Lactoperoxidase
    Protein Accession:
    P22079
    Secondary Accessions:
    • A5JUY4
    • E7EMJ3
    • Q13408
    • Q3KNQ2

    Protein attributes for LPO Gene

    Size:
    712 amino acids
    Molecular mass:
    80288 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per heterodimer.;
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPO Gene

Proteomics data for LPO Gene at MOPED

Selected DME Specific Peptides for LPO Gene

Post-translational modifications for LPO Gene

  • Glycosylation at Asn 106, Asn 212, Asn 322, and Asn 358
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for LPO Gene

Protein Domains for LPO Gene

Suggested Antigen Peptide Sequences for LPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22079

UniProtKB/Swiss-Prot:

PERL_HUMAN :
  • Belongs to the peroxidase family. XPO subfamily.
Family:
  • Belongs to the peroxidase family. XPO subfamily.
genes like me logo Genes that share domains with LPO: view

No data available for Gene Families for LPO Gene

Function for LPO Gene

Molecular function for LPO Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O
UniProtKB/Swiss-Prot Function:
Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.

Enzyme Numbers (IUBMB) for LPO Gene

Gene Ontology (GO) - Molecular Function for LPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity --
GO:0020037 heme binding IEA --
GO:0036393 thiocyanate peroxidase activity IDA 12626341
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LPO: view

Phenotypes for LPO Gene

genes like me logo Genes that share phenotypes with LPO: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPO

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LPO Gene

Localization for LPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPO Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPO Gene COMPARTMENTS Subcellular localization image for LPO gene
Compartment Confidence
extracellular 5
plasma membrane 5
chloroplast 2
cytoskeleton 1
cytosol 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 24248522
GO:0005737 cytoplasm IEA --
GO:0016323 basolateral plasma membrane IDA 19059195
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with LPO: view

Pathways & Interactions for LPO Gene

SuperPathways for LPO Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with LPO: view

Pathways by source for LPO Gene

1 KEGG pathway for LPO Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for LPO Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000262290%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000257430%0d%0a9606.ENSP00000327251%0d%0a9606.ENSP00000337459%0d%0a
Selected Interacting proteins: ENSP00000262290 for LPO Gene via STRING

Gene Ontology (GO) - Biological Process for LPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0006979 response to oxidative stress NAS 8964511
GO:0018969 thiocyanate metabolic process IDA 12626341
GO:0042742 defense response to bacterium IDA 12626341
GO:0042744 hydrogen peroxide catabolic process IEA --
genes like me logo Genes that share ontologies with LPO: view

No data available for SIGNOR curated interactions for LPO Gene

Drugs & Compounds for LPO Gene

(34) Drugs for LPO Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Phenylalanine Approved Nutra 0
Dapsone Approved, Investigational Pharma 61
Daunorubicin Approved Pharma 244
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1525
Epinephrine Approved Pharma 768

(52) Additional Compounds for LPO Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Hypothiocyanite
  • Cyanosulfoxylate
  • Hypothiocyanite
  • N,6-Didehydro-3,6-dihydro-3-methyl-Adenosine
  • OSCN-Hypothiocyanite ion
63296-34-4
2-Phenylacetamide
  • (alpha-)2-Phenylacetamide
  • 2-Phenyl-Acetamide
  • alpha-Phenylacetamide
  • alpha-Toluamide
  • alpha-Toluimidic acid
103-81-1
methanol
  • Alcool methylique
  • Alcool metilico
  • Carbinol
  • CH3OH
  • Colonial spirit
67-56-1
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with LPO: view

Transcripts for LPO Gene

Unigene Clusters for LPO Gene

Lactoperoxidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPO Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for LPO Gene

GeneLoc Exon Structure for
LPO
ECgene alternative splicing isoforms for
LPO

Expression for LPO Gene

mRNA expression in normal human tissues for LPO Gene

mRNA differential expression in normal tissues according to GTEx for LPO Gene

This gene is overexpressed in Minor Salivary Gland (x42.0).

Protein differential expression in normal tissues from HIPED for LPO Gene

This gene is overexpressed in Salivary gland (36.7), Saliva (20.3), and Skin (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LPO Gene



SOURCE GeneReport for Unigene cluster for LPO Gene Hs.234742

mRNA Expression by UniProt/SwissProt for LPO Gene

P22079-PERL_HUMAN
Tissue specificity: Mammary gland; milk and salivary gland. Found in bronchial submucosal glands.
genes like me logo Genes that share expression patterns with LPO: view

Protein tissue co-expression partners for LPO Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LPO Gene

Orthologs for LPO Gene

This gene was present in the common ancestor of animals.

Orthologs for LPO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPO 35
  • 85.91 (n)
  • 83.01 (a)
LPO 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPO 35
  • 86.14 (n)
  • 84.97 (a)
LPO 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpo 35
  • 81.24 (n)
  • 79.69 (a)
Lpo 16
Lpo 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPO 35
  • 99.69 (n)
  • 99.69 (a)
LPO 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpo 35
  • 81.57 (n)
  • 79.75 (a)
oppossum
(Monodelphis domestica)
Mammalia LPO 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPO 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mpx 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10211 37
  • 36 (a)
CG5873 37
  • 31 (a)
CG6879 37
  • 34 (a)
CG6969 37
  • 31 (a)
CG8913 37
  • 25 (a)
Pxd 37
  • 32 (a)
pxt 37
  • 29 (a)
CG5873 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C46A5.4 37
  • 33 (a)
F09F3.5 37
  • 30 (a)
K10B4.1 37
  • 33 (a)
R08F11.7 37
  • 31 (a)
ZK430.8 37
  • 35 (a)
R08F11.7 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
Species with no ortholog for LPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LPO Gene

ENSEMBL:
Gene Tree for LPO (if available)
TreeFam:
Gene Tree for LPO (if available)

Paralogs for LPO Gene

Paralogs for LPO Gene

(6) SIMAP similar genes for LPO Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LPO: view

Variants for LPO Gene

Sequence variations from dbSNP and Humsavar for LPO Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2240262 -- 58,241,749(-) AATTT(A/G)TATCT intron-variant
rs2240263 -- 58,239,916(-) GAGAA(A/G)TTCAG intron-variant
rs2301869 -- 58,255,147(-) GAAGA(A/T)ATGAA intron-variant
rs2301870 - 58,254,966(-) CTGCA(C/T)GAAGG missense, reference, nc-transcript-variant, intron-variant
rs3744104 -- 58,267,907(-) GCCCA(A/G)AATGG reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for LPO Gene

Variant ID Type Subtype PubMed ID
nsv517229 CNV Gain+Loss 19592680
nsv509663 CNV Insertion 20534489

Variation tolerance for LPO Gene

Residual Variation Intolerance Score: 21.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.45; 77.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPO Gene

HapMap Linkage Disequilibrium report
LPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPO Gene

Disorders for LPO Gene

MalaCards: The human disease database

(5) MalaCards diseases for LPO Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
dental caries
  • dental caries pit and fissure
atrophic glossitis
  • atrophy of tongue papillae
common cold
  • acute viral rhinopharyngitis
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
asthma
  • asthma, protection against
- elite association
Search LPO in MalaCards View complete list of genes associated with diseases

Relevant External Links for LPO

Genetic Association Database (GAD)
LPO
Human Genome Epidemiology (HuGE) Navigator
LPO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPO
genes like me logo Genes that share disorders with LPO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPO Gene

Publications for LPO Gene

  1. Molecular cloning of cDNAs encoding bovine and human lactoperoxidase. (PMID: 2222811) Dull T.J. … Seilhamer J.J. (DNA Cell Biol. 1990) 2 23 67
  2. Catalytic scavenging of peroxynitrite by lactoperoxidase in the absence and presence of bicarbonate. (PMID: 19929249) Gebicka L. … Gebicki J.L. (Free Radic. Res. 2010) 23 67
  3. Purification of lactoferrin using hydroxyapatite. (PMID: 20308020) Ng P.K. … Yoshitake T. (J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2010) 23 67
  4. Regulation of sodium/iodide symporter and lactoperoxidase expression in four human breast cancer cell lines. (PMID: 19794300) Sponziello M. … Russo D. (J. Endocrinol. Invest. 2010) 23 67
  5. Sequential adsorption of bovine mucin and lactoperoxidase to various substrates studied with quartz crystal microbalance with dissipation. (PMID: 20184356) Halthur T.J. … Feiler A. (Langmuir 2010) 23 67

Products for LPO Gene

Sources for LPO Gene

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