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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LPL Gene

protein-coding   GIFtS: 73
GCID: GC08P019759

Lipoprotein Lipase


(Previous symbol: LIPD)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lipoprotein Lipase1 2
LIPD1 2 3 5
EC 3.1.1.343 8
HDLCQ112 5
EC 3.1.18

External Ids:    HGNC: 66771   Entrez Gene: 40232   Ensembl: ENSG000001754457   OMIM: 6097085   UniProtKB: P068583   

Export aliases for LPL gene to outside databases

Previous GC identifers: GC08P019672 GC08P019859 GC08P019807 GC08P019841 GC08P018336


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LPL Gene:
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a
homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated
lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less
extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. (provided by RefSeq, Jul 2008)

GeneCards Summary for LPL Gene: 
LPL (lipoprotein lipase) is a protein-coding gene. Diseases associated with LPL include lipoprotein lipase deficiency, and familial lipoprotein lipase deficiency, and among its related super-pathways are Statin Pathway and Parkinson's disease. GO annotations related to this gene include triglyceride lipase activity and receptor binding. An important paralog of this gene is LIPH.

UniProtKB/Swiss-Prot: LIPL_HUMAN, P06858
Function: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and
very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to
the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the
luminal surface of vascular endothelium (By similarity)

summary for LPL Gene:
Lipoprotein lipase (LPL), like LIPG, is a vascular lipase, however it is not synthesized in endothelial
cells. It is anchored to the capillary endothelium by proteoglycans and catalyzes the hydrolysis of
triglycerides to release free fatty acids into the circulation. LPL therefore initiates the processing of
triglyceride-rich lipoproteins such as chylomicrons and VLDL.

Gene Wiki entry for LPL (Lipoprotein lipase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LPL gene promoter:
         STAT1   Sp1   AP-1   ATF-2   Ik-2   COMP1   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPL promoter sequence
   Search SABiosciences Chromatin IP Primers for LPL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p22

LPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPL gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P019759:  view genomic region     (about GC identifiers)

Start:
19,759,228 bp from pter      End:
19,824,770 bp from pter
Size:
65,543 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LIPL_HUMAN, P06858 (See protein sequence)
Recommended Name: Lipoprotein lipase precursor  
Size: 475 amino acids; 53162 Da
Subunit: Homodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence
of lipids. Interacts with GPIHBP1
Subcellular location: Cell membrane (By similarity); Lipid-anchor, GPI-anchor (By similarity). Secreted (By
similarity). Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich
lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles
(By similarity)
Secondary accessions: B2R5T9 Q16282 Q16283 Q96FC4

Explore the universe of human proteins at neXtProt for LPL: NX_P06858

Explore proteomics data for LPL at MOPED 

Post-translational modifications:

  • UniProtKB: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06858

  • 4/25 DME Specific Peptides for LPL (P06858) (see all 25)
     SHLQKGK  RLSPDDA  VDWLSRA  KCSHERS 

    LPL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LPL Protein Expression
    REFSEQ proteins: NP_000228.1  
    ENSEMBL proteins: 
     ENSP00000428496   ENSP00000428237   ENSP00000428557   ENSP00000309757   ENSP00000431028  
    Reactome Protein details: P06858
    Human Recombinant Protein Products for LPL: 
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    Novus Biologicals LPL Protein
    Novus Biologicals LPL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for LPL
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA12573449
    GO:0005886plasma membrane IEA--
    GO:0009986cell surface IEA--
    GO:0031012extracellular matrix IEA--

    LPL for ontologies           About GeneDecksing



    LPL Antibody Products: 
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    Assay Products for LPL: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000734 Lipase
     IPR016272 Lipoprotein_lipase_LIPH
     IPR001024 LipOase_LH2
     IPR008976 Lipase_LipOase
     IPR013818 Lipase_N

    Graphical View of Domain Structure for InterPro Entry P06858

    ProtoNet protein and cluster: P06858

    4 Blocks protein domains:
    IPB000734 Lipase
    IPB001024 Lipoxygenase
    IPB002330 Lipoprotein lipase signature
    IPB008262 Lipase


    UniProtKB/Swiss-Prot: LIPL_HUMAN, P06858
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family
    Similarity: Contains 1 PLAT domain


    LPL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIPL_HUMAN, P06858
    Function: The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and
    very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to
    the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the
    luminal surface of vascular endothelium (By similarity)
    Catalytic activity: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate

         Genatlas biochemistry entry for LPL:
    lipoprotein lipase,50.4kDa,serine esterase with high homology to LIPC,PNLIP,expressed in adipocytes,striated
    muscle,located on the luminal surface of capillary endothelial cells,involved in plasma lipid transport

         Enzyme Numbers (IUBMB): EC 3.1.1.341 2 EC 3.1.12

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004465lipoprotein lipase activity ISS10727238
    GO:0004620phospholipase activity ISS10727238
    GO:0004806triglyceride lipase activity ISS10727238
    GO:0005102receptor binding IPI10085125
    GO:0005515protein binding IPI17997385
         
    LPL for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for LPL:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  G0/1 arrest  Increased G1 DNA content 
     Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lpl):
     adipose tissue  cardiovascular system  growth/size  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  muscle  respiratory system 

    LPL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LPL: Lpltm1Sem Lpltm1Bres

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LPL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LPL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LPL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LPL 

    miRNA
    Products:
        
    miRTarBase miRNAs that target LPL:
    hsa-mir-155 (MIRT001542), hsa-mir-138 (MIRT005491), hsa-mir-29a (MIRT005584)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LPL
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LPL (see all 9):
    hsa-miR-588 hsa-miR-27a hsa-miR-29a hsa-miR-29c hsa-miR-3672 hsa-miR-1303 hsa-miR-590-3p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidLPL 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for LPL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPL
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LPL About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Statin Pathway, Pharmacodynamics
    Statin Pathway0.73
    Statin Pathway, Pharmacodynamics0.73
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    3Lipoprotein metabolism
    Lipoprotein metabolism0.57
    Lipid digestion, mobilization, and transport0.56
    Chylomicron-mediated lipid transport0.57
    4Visual phototransduction
    Visual phototransduction0.48
    Diseases associated with visual transduction0.47
    Retinoid metabolism and transport0.48
    5Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7 BioSystems Pathways for LPL (see all 7)
        Vitamin A and carotenoid metabolism
    Adipogenesis
    Statin Pathway
    SREBP signalling
    Fatty Acid Beta Oxidation


    5/12        Reactome Pathways for LPL (see all 12)
        Diseases associated with visual transduction
    Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Metabolism
    Chylomicron-mediated lipid transport

    1 PharmGKB Pathway for LPL
        Statin Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for LPL):
        Glycerolipid metabolism
    PPAR signaling pathway
    Alzheimer's disease


    LPL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for LPL (P068582, 3 ENSP000003097574) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3832, 3MINT-63419 I2D: score=5 
    LUC7L2Q9Y3832, 3MINT-63419 I2D: score=5 
    ASCC2Q9H1I82, 3MINT-65463 I2D: score=5 
    COPS6Q7L5N12, 3MINT-63416 I2D: score=5 
    KIAA1377Q9P2H02, 3MINT-63418 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0006629lipid metabolic process ----
    GO:0006633fatty acid biosynthetic process ISS--
    GO:0006641triglyceride metabolic process ISS10727238
    GO:0006644phospholipid metabolic process ISS10727238

    LPL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LPL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for LPL available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JZL 184Monoacylglycerol lipase (MAGL) inhibitor[1101854-58-3]
    Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity [96829-58-2]
    Pristimerin Potent, reversible MAGL inhibitor [1258-84-0]
    GSK 264220AEndothelial lipase and lipoprotein lipase inhibitor[685506-42-7]

    10/1143 HMDB Compounds for LPL (see all 1143)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    1 DrugBank Compound for LPL    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tyloxapol-- 25301-02-4targetinhibitor9406449 16839786 1493594

    10/121 Novoseek inferred chemical compound relationships for LPL gene (see all 121)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 84.5 682 10727238 (6), 8908157 (4), 1466662 (3), 1401083 (3) (see all 99)
    cholesterol 84.2 415 1501422 (5), 9193431 (4), 10785873 (4), 8857920 (4) (see all 99)
    triacylglycerol 79 148 10403579 (4), 18751379 (4), 2375781 (3), 11971937 (3) (see all 71)
    cholesterol ester 76.5 55 8645351 (4), 9627145 (3), 12919138 (2), 11284423 (2) (see all 33)
    hind iii 76.4 81 16364275 (3), 18590804 (3), 1466662 (2), 15189363 (2) (see all 47)
    fatty acid 74.1 215 20410100 (3), 16307734 (3), 1894793 (2), 8166251 (2) (see all 99)
    heparin 71.2 378 7811745 (7), 12960955 (7), 15527497 (7), 8810923 (6) (see all 99)
    asp 250 70.5 6 8973094 (1), 1619366 (1), 7706936 (1)
    glycerol 3-phosphate 64.7 41 8928727 (1), 9062891 (1), 17406767 (1), 1411264 (1) (see all 26)
    glucose 63.5 211 9414485 (5), 16555944 (5), 9519750 (4), 9239412 (3) (see all 99)

    Search CenterWatch for drugs/clinical trials and news about LPL / LIPL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for LPL gene: 
    NM_000237.2  

    Unigene Cluster for LPL:

    Lipoprotein lipase
    Hs.180878  [show with all ESTs]
    Unigene Representative Sequence: NM_000237
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520959 ENST00000524029 ENST00000522701 ENST00000311322(uc003wzk.4)
    ENST00000519773 ENST00000521994 ENST00000523696

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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LPL (see all 9):
    hsa-miR-588 hsa-miR-27a hsa-miR-29a hsa-miR-29c hsa-miR-3672 hsa-miR-1303 hsa-miR-590-3p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidLPL 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): LPL (NM_000478)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPL
    Sirion Biotech Customized lentivirus for stable overexpression of LPL 
                         Customized lentivirus expression plasmids for stable overexpression of LPL 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LPL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LPL

    Additional mRNA sequence: 

    AK092286.1 AK222464.1 AK290290.1 AK297164.1 AK312311.1 BC011353.1 BT006726.1 CR457054.1 
    M15856.1 M26380.1 S78266.1 X14390.1 X54516.1 

    17 DOTS entries:

    DT.119216  DT.101963630  DT.100807358  DT.120638148  DT.99974904  DT.120638161  DT.95073909  DT.120638185 
    DT.100687418  DT.100824351  DT.120638144  DT.120638147  DT.120638154  DT.120638156  DT.120638198  DT.92440268 
    DT.95073943 

    24/338 AceView cDNA sequences (see all 338):

    AU122490 BE503647 AU100389 BP348081 BU730747 AI358352 F02348 AA349006 
    AU130815 BX433168 AU122755 CK299341 AW009950 AU102372 BE465407 BF476659 
    BI490006 AI096515 CR605471 H27789 AW300544 N92579 BM707766 CA406476 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LPL    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
    SP1:                                -                                                                           
    SP2:        -                       -                                                                           
    SP3:                          -     -     -     -     -     -     -     -                                       
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for LPL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LPL expression in normal human tissues (normalized intensities)      LPL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGATGTG
    LPL Expression
    About this image


    LPL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/27 selected tissues (see all 27) fully expand
     
     Brain (Nervous System)    fully expand to see all 26 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Human Hippocampal Astrocytes   
             Trigeminal Ganglion   
     
     Adipose (Muscoskeletal System)    fully expand to see all 13 entries
             Visceral White Adipocytes Visceral White Adipose
             HyStem+BMP4-induced E15 cells
             Adipocyte   
     
     Limb (Muscoskeletal System)    fully expand to see all 9 entries
             Bone Marrow Stromal Cells Pelvic Girdle
             Autopod
             limb/hindlimb   
     
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Atrioventricular Node
             heart/atrium   
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
             HyStem+BMP4-induced E15 cells
             skeleton/cranium   

    See LPL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LPL

    SOURCE GeneReport for Unigene cluster: Hs.180878
        SABiosciences Expression via Pathway-Focused PCR Arrays including LPL (see all 12): 
              Fatty Acid Metabolism in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Alzheimer's Disease in human mouse rat
              Hepatotoxicity in human mouse rat
              Adipogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LPL gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lpl1 , 5 lipoprotein lipase1, 5 88.05(n)1
    93.04(a)1
      8 (33.88 cM)5
    169561  NM_008509.21  NP_032535.21 
     688804915 
    chicken
    (Gallus gallus)
    Aves LPL1 lipoprotein lipase 74.04(n)
    76.55(a)
      396219  NM_205282.1  NP_990613.1 
    lizard
    (Anolis carolinensis)
    Reptilia LPL6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    2(75017732-75035688)
    zebrafish
    (Danio rerio)
    Actinopterygii lpl2 lipoprotein lipase 78.06(n)   30354  BC064296.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19863 lipoprotein lipase 36(a)
    (best of 3)
      9A3   --


    ENSEMBL Gene Tree for LPL (if available)
    TreeFam Gene Tree for LPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LPL gene
    LIPH2  LIPC2  LIPG2  PNLIPRP32  PNLIPRP22  PNLIP2  LIPI2  PLA1A2  
    PNLIPRP12  
    5 SIMAP similar genes for LPL using alignment to 7 protein entries:     LIPL_HUMAN (see all proteins):
    LIPG    LIPC    PNLIPRP1    PNLIP    PNLIPRP2

    LPL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/934 SNPs in LPL are shown (see all 934)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0579144
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0579142 N S mis40--------
    VAR_0579344
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0579342 Y H mis40--------
    VAR_0579404
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0579402 S R mis40--------
    VAR_0579204
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0579202 D H mis40--------
    VAR_0579224
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0579222 E G mis40--------
    VAR_0042254
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0042252 G E mis40--------
    VAR_0042224
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0042222 A T mis40--------
    VAR_0042374
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0042372 S G mis40--------
    VAR_0579334
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0579332 L V mis40--------
    VAR_0042424
    Lipoprotein lipase deficiency (LPL deficiency)4--see VAR_0042422 A T mis40--------

    HapMap Linkage Disequilibrium report for LPL (19759228 - 19824770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LPL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv890632CNV Loss21882294
    esv32767CNV Loss17666407
    nsv890625CNV Gain21882294
    nsv515694CNV Gain19592680
    nsv522185CNV Gain19592680


    Human Gene Mutation Database (HGMD): LPL
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LPL
    DNA2.0 Custom Variant and Variant Library Synthesis for LPL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609708   
    OMIM disorders: 238600  144250  
    UniProtKB/Swiss-Prot: LIPL_HUMAN, P06858
  • Lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]: Recessive disorder usually manifesting in
    childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis,
    eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 20/139 diseases for LPL (see all 139):    About MalaCards
    lipoprotein lipase deficiency    familial lipoprotein lipase deficiency    familial combined hyperlipoproteinemia    coronary heart disease
    lipase deficiency combined    hyperlipoproteinemia type v    hepatic lipase deficiency    lipid metabolism disorder
    biotinidase deficiency    hyperlipoproteinemia type iii    familial combined hyperlipidemia    boutonneuse fever
    focal glomerulosclerosis    ischemic heart disease    metabolic syndrome x    cetp deficiency
    hypertriglyceridemia    hypoalphalipoproteinemias    familial hypertriglyceridemia    aortic atherosclerosis

    11 diseases from the University of Copenhagen DISEASES database for LPL:
    Familial hyperlipidemia     Atherosclerosis     Diabetes mellitus     Familial hypertriglyceridemia
    Coronary heart disease     Pancreatitis     Hyperinsulinism     Hypertension
    Hyperglycemia     Kidney disease     Ischemic heart disease

    LPL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for LPL gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endogenous hypertriglyceridemia 93.3 95 7811743 (3), 10481930 (2), 1619366 (2), 1907278 (2) (see all 64)
    hypertriglyceridemia 91.4 312 10560236 (5), 8675619 (4), 10619999 (3), 17919884 (3) (see all 99)
    hypertriglyceridemias familial 83.1 26 7609317 (3), 15534935 (1), 9209790 (1), 9629518 (1) (see all 16)
    hyperlipidemia familial combined 81.3 23 8551675 (1), 16822320 (1), 1619366 (1), 8049185 (1) (see all 13)
    dyslipidemia 76.4 53 16741292 (3), 19639021 (2), 8790727 (2), 15262189 (2) (see all 33)
    hyperlipidemia 74.9 63 14660566 (2), 16606335 (2), 9382958 (2), 1968704 (2) (see all 39)
    atherosclerosis 72.7 152 15639492 (4), 10484615 (4), 15545743 (3), 8692976 (3) (see all 75)
    hyperlipoproteinemia 72.3 15 8682644 (2), 14669227 (2), 1943724 (2), 11194013 (1) (see all 9)
    hyperlipoproteinemia type iii 71.4 16 19233944 (2), 1430218 (2), 2259550 (1), 7583546 (1) (see all 9)
    lipoprotein disorder 70.9 4 15719845 (1), 1417963 (1), 9185775 (1), 11122693 (1)

    Genatlas disease: LPL
    human blood pressure QTL at or near the lipoprotein lipase gene,accounting for 52-73% of variation in systolic bp
    in the data set (Taiwanese population)

    GeneTests: LPL
    GeneReviews: LPL
    Genetic Association Database (GAD): LPL
    Human Genome Epidemiology (HuGE) Navigator: LPL (355 documents)

    Export disorders for LPL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LPL gene, integrated from 9 sources (see all 2153):
    (articles sorted by number of sources associating them with LPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human lipoprotein lipase (LPL) promoter: evidence of two cis-regulatory regions, LP-alpha and LP-beta, of importance for the differentiation-linked induction of the LPL gene during adipogenesis. (PubMed id 1406652)1, 2, 9 Enerbaeck S.... Bjursell G. (1992)
    2. Genetic association study of selected candidate genes (ApoB, LPL, Leptin) and telomere length in obese and hypertensive individuals. (PubMed id 19772655)1, 4, 9 Das B....Seshadri M. (2009)
    3. Lipoprotein Lipase Mutation S447X Associated With Pancreatic Calcification and Steatorrhea in Hyperlipidemic Pancreatitis. (PubMed id 19034041)1, 4, 9 Chang Y.T....Wong J.M. (2008)
    4. Apolipoprotein E and lipoprotein lipase gene polymorphisms interaction on the atherogenic combined expression of hypertriglyceridemia and hyperapobetalipoproteinemia phenotypes. (PubMed id 17848837)1, 4, 9 Perron P....Gaudet D. (2007)
    5. Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults. (PubMed id 17157861)1, 4, 9 Nettleton J.A....Folsom A.R. (2007)
    6. Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotype. (PubMed id 17032721)1, 4, 9 Goodarzi M.O....Rotter J.I. (2007)
    7. Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein epsilon, lipoprotein lipase and cholesteryl ester transfer protein. Genetique de la Nephropathie Diabetique Study Group. Donnees Epidemiologiques sur le Syndrome d'Insulino-Resistance Study Group. (PubMed id 11096142)1, 4, 9 Hadjadj S....Marre M. (2000)
    8. Associations for lipoprotein lipase and peroxisome pr oliferator-activated receptor-gamma gene and coronary artery disease in an Indi an population. (PubMed id 20430250)1, 4, 9 AshokKumar M....Emmanuel C. (2010)
    9. Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos. (PubMed id 20410100)1, 4, 9 Voruganti V.S....Comuzzie A.G. (2010)
    10. Diagnostic value of post-heparin lipase testing in detecting common genetic variants in the LPL and LIPC genes. (PubMed id 19367320)1, 4, 9 van Hoek M....Sijbrands E.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4023 HGNC: 6677 AceView: LPL Ensembl:ENSG00000175445 euGenes: HUgn4023
    ECgene: LPL Kegg: 4023 H-InvDB: LPL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LPL Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/LPL
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LPL
    Wikipedia http://en.wikipedia.org/wiki/Lipoprotein_lipase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LPL gene:
    Search GeneIP for patents involving LPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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