External Ids for LPL Gene
Previous HGNC Symbols for LPL Gene
Previous GeneCards Identifiers for LPL Gene
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
GeneCards Summary for LPL Gene
LPL (Lipoprotein Lipase) is a Protein Coding gene. Diseases associated with LPL include lipoprotein lipase deficiency and familial lipoprotein lipase deficiency. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include receptor binding and triglyceride lipase activity. An important paralog of this gene is PNLIPRP1.
UniProtKB/Swiss-Prot for LPL Gene
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).
Lipoprotein lipase (LPL), like LIPG, is a vascular lipase, however it is not synthesized in endothelial cells. It is anchored to the capillary endothelium by proteoglycans and catalyzes the hydrolysis of triglycerides to release free fatty acids into the circulation. LPL therefore initiates the processing of triglyceride-rich lipoproteins such as chylomicrons and VLDL.