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Aliases for LPIN3 Gene

Aliases for LPIN3 Gene

  • Lipin 3 2 3 5
  • LIPN3L 3 4
  • Phosphatidate Phosphatase LPIN3 3
  • Lipin 3-Like 2
  • Lipin-3-Like 4
  • EC 3.1.3.4 4
  • Lipin-3 4
  • SMP2 3

External Ids for LPIN3 Gene

Previous HGNC Symbols for LPIN3 Gene

  • LIPN3L

Previous GeneCards Identifiers for LPIN3 Gene

  • GC20U990061
  • GC20M039662
  • GC20P040612
  • GC20P040659
  • GC20P039402
  • GC20P039969
  • GC20P036707

Summaries for LPIN3 Gene

Entrez Gene Summary for LPIN3 Gene

  • The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for LPIN3 Gene

LPIN3 (Lipin 3) is a Protein Coding gene. Among its related pathways are Metabolism and Mitotic Prophase. GO annotations related to this gene include transcription coactivator activity and phosphatidate phosphatase activity. An important paralog of this gene is LPIN2.

UniProtKB/Swiss-Prot for LPIN3 Gene

  • Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPIN3 Gene

Genomics for LPIN3 Gene

Regulatory Elements for LPIN3 Gene

Enhancers for LPIN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F041145 1.7 FANTOM5 Ensembl ENCODE 26.7 -187.8 -187817 15.5 PKNOX1 ATF1 SIN3A ARID4B YBX1 GATA2 FOS SP5 JUNB REST LPIN3 EMILIN3 ZHX3 PLCG1 CHD6 PLCG1-AS1 MIR6871
GH20F041692 1.4 Ensembl ENCODE 25.8 +352.8 352825 2.8 PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A YBX1 DMAP1 YY1 LPIN3 TOP1 GC20M041699 RNU6-1018P
GH20F041231 1.5 FANTOM5 Ensembl ENCODE 24 -107.5 -107493 3.9 ARID4B ZNF48 RAD21 YY1 SCRT2 RCOR1 FOS MIXL1 EGR2 SMARCC1 LPIN3 ZHX3 PIR61683 RN7SL615P GC20M041291
GH20F041136 1.4 FANTOM5 ENCODE 23.3 -200.9 -200854 7.5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF207 KLF13 SP3 LPIN3 PLCG1 CHD6 PLCG1-AS1 MIR6871
GH20F041308 1.3 FANTOM5 Ensembl ENCODE 20.3 -31.6 -31573 3.0 PKNOX1 TAL1 YBX1 NCOR1 PRDM10 TRIM24 CREM ZBTB20 HLF BHLHE40 LPIN3 EMILIN3 PLCG1 PLCG1-AS1 ZHX3 RN7SL615P GC20M041291
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LPIN3 on UCSC Golden Path with GeneCards custom track

Promoters for LPIN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000401167 20 1601 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 DEK SP3

Genomic Location for LPIN3 Gene

Chromosome:
20
Start:
41,340,780 bp from pter
End:
41,360,585 bp from pter
Size:
19,806 bases
Orientation:
Plus strand

Genomic View for LPIN3 Gene

Genes around LPIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPIN3 Gene

Proteins for LPIN3 Gene

  • Protein details for LPIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQK8-LPIN3_HUMAN
    Recommended name:
    Phosphatidate phosphatase LPIN3
    Protein Accession:
    Q9BQK8
    Secondary Accessions:
    • B2RTT5
    • Q5TDB9
    • Q9NPY8
    • Q9UJE5

    Protein attributes for LPIN3 Gene

    Size:
    851 amino acids
    Molecular mass:
    93614 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LPIN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPIN3 Gene

Post-translational modifications for LPIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LPIN3 Gene

Domains & Families for LPIN3 Gene

Gene Families for LPIN3 Gene

HGNC:
IUPHAR :

Protein Domains for LPIN3 Gene

Suggested Antigen Peptide Sequences for LPIN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQK8

UniProtKB/Swiss-Prot:

LPIN3_HUMAN :
  • Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
  • Belongs to the lipin family.
Domain:
  • Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
  • Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.
Family:
  • Belongs to the lipin family.
genes like me logo Genes that share domains with LPIN3: view

Function for LPIN3 Gene

Molecular function for LPIN3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide.
UniProtKB/Swiss-Prot Function:
Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity).

Enzyme Numbers (IUBMB) for LPIN3 Gene

Gene Ontology (GO) - Molecular Function for LPIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IBA --
GO:0008195 phosphatidate phosphatase activity EXP,IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with LPIN3: view

Phenotypes for LPIN3 Gene

genes like me logo Genes that share phenotypes with LPIN3: view

Animal Models for LPIN3 Gene

MGI Knock Outs for LPIN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for LPIN3

miRNA for LPIN3 Gene

miRTarBase miRNAs that target LPIN3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPIN3 Gene

Localization for LPIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPIN3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPIN3 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
cytosol 3

Gene Ontology (GO) - Cellular Components for LPIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with LPIN3: view

Pathways & Interactions for LPIN3 Gene

genes like me logo Genes that share pathways with LPIN3: view

Gene Ontology (GO) - Biological Process for LPIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0009062 fatty acid catabolic process IBA --
genes like me logo Genes that share ontologies with LPIN3: view

No data available for SIGNOR curated interactions for LPIN3 Gene

Drugs & Compounds for LPIN3 Gene

(2) Drugs for LPIN3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with LPIN3: view

Transcripts for LPIN3 Gene

mRNA/cDNA for LPIN3 Gene

(16) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LPIN3 Gene

Lipin 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPIN3 Gene

No ASD Table

Relevant External Links for LPIN3 Gene

GeneLoc Exon Structure for
LPIN3
ECgene alternative splicing isoforms for
LPIN3

Expression for LPIN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LPIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LPIN3 Gene

This gene is overexpressed in Serum (51.0) and Bone (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LPIN3 Gene



Protein tissue co-expression partners for LPIN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of LPIN3 Gene:

LPIN3

SOURCE GeneReport for Unigene cluster for LPIN3 Gene:

Hs.25897

mRNA Expression by UniProt/SwissProt for LPIN3 Gene:

Q9BQK8-LPIN3_HUMAN
Tissue specificity: Significant expression in intestine and other regions of the gastrointestinal tract.
genes like me logo Genes that share expression patterns with LPIN3: view

Primer Products

No data available for mRNA differential expression in normal tissues for LPIN3 Gene

Orthologs for LPIN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LPIN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPIN3 34 35
  • 99.02 (n)
dog
(Canis familiaris)
Mammalia LPIN3 34 35
  • 86.21 (n)
cow
(Bos Taurus)
Mammalia LPIN3 34 35
  • 85.42 (n)
rat
(Rattus norvegicus)
Mammalia Lpin3 34
  • 83.08 (n)
mouse
(Mus musculus)
Mammalia Lpin3 34 16 35
  • 82.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LPIN3 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPIN3 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPIN3 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:123305 35
  • 44 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Lpin 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lpin-1 35
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAH1 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
Species where no ortholog for LPIN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LPIN3 Gene

ENSEMBL:
Gene Tree for LPIN3 (if available)
TreeFam:
Gene Tree for LPIN3 (if available)

Paralogs for LPIN3 Gene

Paralogs for LPIN3 Gene

(3) SIMAP similar genes for LPIN3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LPIN3: view

Variants for LPIN3 Gene

Sequence variations from dbSNP and Humsavar for LPIN3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10427471 -- 41,354,585(+) AACAA(C/T)GTAAG intron-variant
rs111408954 -- 41,341,720(+) GCTCA(C/T)GCCTG intron-variant
rs111519678 -- 41,357,175(+) TCGAC(A/G)GCACC nc-transcript-variant, reference, missense
rs111524209 -- 41,348,439(+) CTCTG(C/T)TGGGG intron-variant
rs111595653 -- 41,345,431(+) ACAGG(A/G)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPIN3 Gene

Variant ID Type Subtype PubMed ID
dgv245n21 CNV loss 19592680
esv2722419 CNV deletion 23290073
esv2722420 CNV deletion 23290073
nsv1064246 CNV loss 25217958
nsv3381 CNV deletion 18451855
nsv833984 CNV loss 17160897
nsv954039 CNV deletion 24416366

Variation tolerance for LPIN3 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.27; 94.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPIN3 Gene

Human Gene Mutation Database (HGMD)
LPIN3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPIN3 Gene

Disorders for LPIN3 Gene

Relevant External Links for LPIN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPIN3

No disorders were found for LPIN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPIN3 Gene

Publications for LPIN3 Gene

  1. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. (PMID: 11138012) PActerfy M. … Reue K. (Nat. Genet. 2001) 2 3 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for LPIN3 Gene

Sources for LPIN3 Gene

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