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Aliases for LPIN3 Gene

Aliases for LPIN3 Gene

  • Lipin 3 2 3
  • Lipin-3 3 4
  • LIPN3L 3 4
  • Lipin 3-Like 2
  • Lipin-3-Like 4
  • EC 3.1.3.4 4
  • SMP2 3

External Ids for LPIN3 Gene

Previous HGNC Symbols for LPIN3 Gene

  • LIPN3L

Previous GeneCards Identifiers for LPIN3 Gene

  • GC20U990061
  • GC20M039662
  • GC20P040612
  • GC20P040659
  • GC20P039402
  • GC20P039969
  • GC20P036707

Summaries for LPIN3 Gene

Entrez Gene Summary for LPIN3 Gene

  • The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for LPIN3 Gene

LPIN3 (Lipin 3) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Metabolism. GO annotations related to this gene include transcription coactivator activity and phosphatidate phosphatase activity. An important paralog of this gene is LPIN1.

UniProtKB/Swiss-Prot for LPIN3 Gene

  • Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPIN3 Gene

Genomics for LPIN3 Gene

Regulatory Elements for LPIN3 Gene

Genomic Location for LPIN3 Gene

Chromosome:
20
Start:
41,340,780 bp from pter
End:
41,360,585 bp from pter
Size:
19,806 bases
Orientation:
Plus strand

Genomic View for LPIN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPIN3 Gene

Proteins for LPIN3 Gene

  • Protein details for LPIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQK8-LPIN3_HUMAN
    Recommended name:
    Phosphatidate phosphatase LPIN3
    Protein Accession:
    Q9BQK8
    Secondary Accessions:
    • B2RTT5
    • Q5TDB9
    • Q9NPY8
    • Q9UJE5

    Protein attributes for LPIN3 Gene

    Size:
    851 amino acids
    Molecular mass:
    93614 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LPIN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPIN3 Gene

Proteomics data for LPIN3 Gene at MOPED

Post-translational modifications for LPIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LPIN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LPIN3 Gene

Domains & Families for LPIN3 Gene

Gene Families for LPIN3 Gene

HGNC:
IUPHAR :

Protein Domains for LPIN3 Gene

Suggested Antigen Peptide Sequences for LPIN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQK8

UniProtKB/Swiss-Prot:

LPIN3_HUMAN :
  • Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
  • Belongs to the lipin family.
Domain:
  • Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
  • Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.
Family:
  • Belongs to the lipin family.
genes like me logo Genes that share domains with LPIN3: view

Function for LPIN3 Gene

Molecular function for LPIN3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-ethylmaleimide.
UniProtKB/Swiss-Prot Function:
Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity).

Enzyme Numbers (IUBMB) for LPIN3 Gene

Gene Ontology (GO) - Molecular Function for LPIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IBA --
GO:0008195 phosphatidate phosphatase activity IBA --
genes like me logo Genes that share ontologies with LPIN3: view

Phenotypes for LPIN3 Gene

GenomeRNAi human phenotypes for LPIN3:
genes like me logo Genes that share phenotypes with LPIN3: view

Animal Model Products

miRNA for LPIN3 Gene

miRTarBase miRNAs that target LPIN3

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for LPIN3 Gene

Localization for LPIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPIN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPIN3 Gene COMPARTMENTS Subcellular localization image for LPIN3 gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LPIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with LPIN3: view

Pathways & Interactions for LPIN3 Gene

genes like me logo Genes that share pathways with LPIN3: view

Pathways by source for LPIN3 Gene

1 BioSystems pathway for LPIN3 Gene
14 Reactome pathways for LPIN3 Gene

Gene Ontology (GO) - Biological Process for LPIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0006644 phospholipid metabolic process TAS --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0009062 fatty acid catabolic process IBA --
genes like me logo Genes that share ontologies with LPIN3: view

No data available for SIGNOR curated interactions for LPIN3 Gene

Drugs & Compounds for LPIN3 Gene

(2) Additional Compounds for LPIN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with LPIN3: view

Transcripts for LPIN3 Gene

mRNA/cDNA for LPIN3 Gene

(15) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LPIN3 Gene

Lipin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPIN3 Gene

No ASD Table

Relevant External Links for LPIN3 Gene

GeneLoc Exon Structure for
LPIN3
ECgene alternative splicing isoforms for
LPIN3

Expression for LPIN3 Gene

mRNA expression in normal human tissues for LPIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LPIN3 Gene

This gene is overexpressed in Serum (51.0) and Bone (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LPIN3 Gene



SOURCE GeneReport for Unigene cluster for LPIN3 Gene Hs.25897

mRNA Expression by UniProt/SwissProt for LPIN3 Gene

Q9BQK8-LPIN3_HUMAN
Tissue specificity: Significant expression in intestine and other regions of the gastrointestinal tract.
genes like me logo Genes that share expression patterns with LPIN3: view

Protein tissue co-expression partners for LPIN3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LPIN3 Gene

Orthologs for LPIN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LPIN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPIN3 35
  • 85.42 (n)
  • 83.02 (a)
LPIN3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPIN3 35
  • 86.21 (n)
  • 83.47 (a)
LPIN3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpin3 35
  • 82.6 (n)
  • 81.26 (a)
Lpin3 16
Lpin3 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPIN3 35
  • 99.02 (n)
  • 98.59 (a)
LPIN3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpin3 35
  • 83.08 (n)
  • 82.6 (a)
oppossum
(Monodelphis domestica)
Mammalia LPIN3 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPIN3 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPIN3 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc:123305 36
  • 44 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Lpin 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lpin-1 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAH1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
Species with no ortholog for LPIN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LPIN3 Gene

ENSEMBL:
Gene Tree for LPIN3 (if available)
TreeFam:
Gene Tree for LPIN3 (if available)

Paralogs for LPIN3 Gene

Paralogs for LPIN3 Gene

(3) SIMAP similar genes for LPIN3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LPIN3: view

Variants for LPIN3 Gene

Sequence variations from dbSNP and Humsavar for LPIN3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2072969 -- 41,357,900(-) CAGTA(C/T)AGGAA synonymous-codon, reference, nc-transcript-variant, missense, intron-variant, downstream-variant-500B
rs4810312 -- 41,340,067(+) AAATG(C/G)ACCTT upstream-variant-2KB
rs4812494 -- 41,339,311(+) ATTTA(A/C)TTTGG upstream-variant-2KB
rs4812495 -- 41,341,554(+) TCCCT(C/G)TGCTA intron-variant
rs4812496 -- 41,341,904(+) CCCAG(C/G)AGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPIN3 Gene

Variant ID Type Subtype PubMed ID
nsv833984 CNV Loss 17160897
nsv3381 CNV Loss 18451855
dgv245n21 CNV Loss 19592680
esv2722419 CNV Deletion 23290073
esv2722420 CNV Deletion 23290073

Variation tolerance for LPIN3 Gene

Residual Variation Intolerance Score: 97.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.27; 94.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPIN3 Gene

HapMap Linkage Disequilibrium report
LPIN3
Human Gene Mutation Database (HGMD)
LPIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPIN3 Gene

Disorders for LPIN3 Gene

Relevant External Links for LPIN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPIN3
genes like me logo Genes that share disorders with LPIN3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPIN3 Gene

Publications for LPIN3 Gene

  1. The lipin family: mutations and metabolism. (PMID: 19369868) Reue K. (Curr. Opin. Lipidol. 2009) 23 67
  2. A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. (PMID: 19717560) Donkor J. … Reue K. (J. Biol. Chem. 2009) 23 67
  3. Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells. (PMID: 19753306) Liu G.H. … Gerace L. (PLoS ONE 2009) 23 67
  4. The lipin protein family: dual roles in lipid biosynthesis and gene expression. (PMID: 18023282) Reue K. … Zhang P. (FEBS Lett. 2008) 23 67
  5. Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism. (PMID: 18791037) Reue K. … Brindley D.N. (J. Lipid Res. 2008) 23 67

Products for LPIN3 Gene

Sources for LPIN3 Gene

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