Aliases for LPIN2 Gene
External Ids for LPIN2 Gene
Previous GeneCards Identifiers for LPIN2 Gene
Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008]
GeneCards Summary for LPIN2 Gene
LPIN2 (Lipin 2) is a Protein Coding gene. Diseases associated with LPIN2 include Majeed Syndrome and Osteomyelitis. Among its related pathways are Regulation of Glucokinase by Glucokinase Regulatory Protein and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include transcription coactivator activity and phosphatidate phosphatase activity. An important paralog of this gene is LPIN1.
UniProtKB/Swiss-Prot for LPIN2 Gene
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).