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Aliases for LPIN1 Gene

Aliases for LPIN1 Gene

  • Lipin 1 2 3 5
  • Phosphatidate Phosphatase LPIN1 3
  • EC 3.1.3.18 61
  • EC 5.4.2.7 61
  • EC 3.1.3.4 4
  • KIAA0188 4
  • Lipin-1 4
  • PAP1 3

External Ids for LPIN1 Gene

Previous GeneCards Identifiers for LPIN1 Gene

  • GC02P011915
  • GC02P011908
  • GC02P011837
  • GC02P011804
  • GC02P011864

Summaries for LPIN1 Gene

Entrez Gene Summary for LPIN1 Gene

  • This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]

GeneCards Summary for LPIN1 Gene

LPIN1 (Lipin 1) is a Protein Coding gene. Diseases associated with LPIN1 include Myoglobinuria, Acute Recurrent, Autosomal Recessive and Genetic Recurrent Myoglobinuria. Among its related pathways are mTOR signaling pathway (KEGG) and Mitotic Prophase. GO annotations related to this gene include transcription coactivator activity and RNA polymerase II transcription factor binding. An important paralog of this gene is LPIN2.

UniProtKB/Swiss-Prot for LPIN1 Gene

  • Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).

Gene Wiki entry for LPIN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPIN1 Gene

Genomics for LPIN1 Gene

Regulatory Elements for LPIN1 Gene

Enhancers for LPIN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G011784 1.3 Ensembl ENCODE dbSUPER 45.4 +107.5 107451 0.7 BCOR HDGF SOX13 CTCF KLF1 ZMYM3 ZNF48 ZNF644 RAD21 ADNP LPIN1 ENSG00000230790 LOC101929752 LOC100506405 MIR548S LOC105373430
GH02G011742 2.1 FANTOM5 Ensembl ENCODE dbSUPER 22 +69.4 69394 9.4 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D LPIN1 LOC101929752 E2F6 ENSG00000230790 GC02M011761
GH02G011696 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19 +20.5 20526 3.6 ELF3 TBP ARID4B DMAP1 RCOR1 FOS EGR2 MXD4 REST KAT8 LPIN1 LOC101929752 ENSG00000230790 NTSR2 CDK8P1 E2F6 LOC100506405
GH02G011778 1.4 Ensembl ENCODE dbSUPER 22.9 +101.4 101439 1.9 ELF3 HDAC1 RB1 CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF48 RAD21 LPIN1 ENSG00000230790 LOC101929752 LOC100506405 NTSR2 CDK8P1 MIR548S LOC105373430
GH02G011752 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +76.4 76358 2.3 PKNOX1 ATF1 WRNIP1 SIN3A FEZF1 TCF12 GATA2 ZNF207 FOS NCOA1 LPIN1 LOC101929752 ENSG00000230790 GC02M011761
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LPIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPIN1 Gene

Chromosome:
2
Start:
11,677,545 bp from pter
End:
11,827,409 bp from pter
Size:
149,865 bases
Orientation:
Plus strand

Genomic View for LPIN1 Gene

Genes around LPIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPIN1 Gene

Proteins for LPIN1 Gene

  • Protein details for LPIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14693-LPIN1_HUMAN
    Recommended name:
    Phosphatidate phosphatase LPIN1
    Protein Accession:
    Q14693
    Secondary Accessions:
    • A8MU38
    • B4DET9
    • B4DGS4
    • B4DGZ6
    • B5MC18
    • B7Z858
    • D6W506
    • E7ESE7
    • F5GY24
    • Q53T25

    Protein attributes for LPIN1 Gene

    Size:
    890 amino acids
    Molecular mass:
    98664 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C.
    Miscellaneous:
    • May represent a candidate gene for human lipodysytropy syndromes.
    SequenceCaution:
    • Sequence=BAA11505.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57200.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG57885.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG57957.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BC018071; Type=Frameshift; Positions=134; Evidence={ECO:0000305};

    Alternative splice isoforms for LPIN1 Gene

neXtProt entry for LPIN1 Gene

Selected DME Specific Peptides for LPIN1 Gene

Q14693:
  • DIDGTIT
  • SDTLGHI

Post-translational modifications for LPIN1 Gene

  • Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex (By similarity).
  • Sumoylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LPIN1 (LPIN1)

Domains & Families for LPIN1 Gene

Gene Families for LPIN1 Gene

HGNC:
IUPHAR :

Protein Domains for LPIN1 Gene

Suggested Antigen Peptide Sequences for LPIN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14693

UniProtKB/Swiss-Prot:

LPIN1_HUMAN :
  • Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA.
  • Belongs to the lipin family.
Domain:
  • Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA.
  • Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
Family:
  • Belongs to the lipin family.
genes like me logo Genes that share domains with LPIN1: view

Function for LPIN1 Gene

Molecular function for LPIN1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.35 mM for phosphatidate (isoform 1); KM=0.24 mM for phosphatidate (isoform 3); KM=0.11 mM for phosphatidate (isoform 4); Temperature dependence: Optimum temperature is 40 degrees Celsius. Thermolabile above 40 degrees Celsius and essentially inactive at 60 degrees Celsius.;
UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Potently inhibited by sphingolipids, in particular, the sphingoid bases sphinganine and sphingosine and ceramide-1-phosphate. Inhibited by concentrations of Mg(2+) and Mn(2+) above their optimums and by Ca(2+), Zn(2+), N-ethylmaleimide and propranolol.
UniProtKB/Swiss-Prot Function:
Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).

Enzyme Numbers (IUBMB) for LPIN1 Gene

Gene Ontology (GO) - Molecular Function for LPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003713 transcription coactivator activity IBA --
GO:0008195 phosphatidate phosphatase activity IBA,EXP --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with LPIN1: view
genes like me logo Genes that share phenotypes with LPIN1: view

Human Phenotype Ontology for LPIN1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for LPIN1 Gene

Localization for LPIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPIN1 Gene

Nucleus membrane. Cytoplasm, cytosol. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPIN1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
mitochondrion 4
cytosol 4
extracellular 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for LPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS 11138012
GO:0005635 nuclear envelope TAS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005741 mitochondrial outer membrane IBA --
genes like me logo Genes that share ontologies with LPIN1: view

Pathways & Interactions for LPIN1 Gene

genes like me logo Genes that share pathways with LPIN1: view

Gene Ontology (GO) - Biological Process for LPIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with LPIN1: view

No data available for SIGNOR curated interactions for LPIN1 Gene

Drugs & Compounds for LPIN1 Gene

(4) Drugs for LPIN1 Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rosiglitazone Approved, Investigational Pharma Full agonist, Agonist Potent PPARγ agonist, Potent and selective PPARgamma agonist; antidiabetic agent. 220
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for LPIN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LPIN1: view

Transcripts for LPIN1 Gene

Unigene Clusters for LPIN1 Gene

Lipin 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPIN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1: - - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for LPIN1 Gene

GeneLoc Exon Structure for
LPIN1
ECgene alternative splicing isoforms for
LPIN1

Expression for LPIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPIN1 Gene

This gene is overexpressed in Muscle - Skeletal (x8.7).

Protein differential expression in normal tissues from HIPED for LPIN1 Gene

This gene is overexpressed in Fetal testis (25.0), Fetal ovary (9.7), Heart (9.2), and Islet of Langerhans (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LPIN1 Gene



NURSA nuclear receptor signaling pathways regulating expression of LPIN1 Gene:

LPIN1

SOURCE GeneReport for Unigene cluster for LPIN1 Gene:

Hs.467740

mRNA Expression by UniProt/SwissProt for LPIN1 Gene:

Q14693-LPIN1_HUMAN
Tissue specificity: Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.

Evidence on tissue expression from TISSUES for LPIN1 Gene

  • Nervous system(4.9)
  • Bone marrow(4.1)
  • Muscle(2.8)
  • Liver(2.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for LPIN1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • nervous
  • skeletal muscle
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • heart
  • heart valve
Abdomen:
  • kidney
General:
  • blood
  • peripheral nerve
  • peripheral nervous system
  • white blood cell
genes like me logo Genes that share expression patterns with LPIN1: view

Primer Products

No data available for Protein tissue co-expression partners for LPIN1 Gene

Orthologs for LPIN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LPIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPIN1 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia LPIN1 34 35
  • 86.64 (n)
cow
(Bos Taurus)
Mammalia LPIN1 34 35
  • 85.45 (n)
rat
(Rattus norvegicus)
Mammalia Lpin1 34
  • 84.04 (n)
mouse
(Mus musculus)
Mammalia Lpin1 34 16 35
  • 83.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LPIN1 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPIN1 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPIN1 34 35
  • 71.63 (n)
lizard
(Anolis carolinensis)
Reptilia LPIN1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpin1 34
  • 68.96 (n)
zebrafish
(Danio rerio)
Actinopterygii lpin1 34 35
  • 64.93 (n)
LPIN1 (2 of 2) 35
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8709 36
  • 40 (a)
Lpin 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H37A05.1 36
  • 43 (a)
lpin-1 35
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAH1 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
Species where no ortholog for LPIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LPIN1 Gene

ENSEMBL:
Gene Tree for LPIN1 (if available)
TreeFam:
Gene Tree for LPIN1 (if available)

Paralogs for LPIN1 Gene

Paralogs for LPIN1 Gene

genes like me logo Genes that share paralogs with LPIN1: view

Variants for LPIN1 Gene

Sequence variations from dbSNP and Humsavar for LPIN1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035874 A colorectal cancer sample
rs119480071 Pathogenic 11,773,666(+) CTGAG(G/T)AAAAC reference, stop-gained
rs119480072 Pathogenic 11,783,834(+) ATAAA(C/T)GAAGC reference, stop-gained
rs119480073 Pathogenic 11,819,590(+) GAAAC(A/C/T)GACCA reference, synonymous-codon, stop-gained
rs730880306 Pathogenic 11,785,078(+) AAAGG(C/T)ACCGC downstream-variant-500B, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for LPIN1 Gene

Variant ID Type Subtype PubMed ID
dgv6692n54 CNV loss 21841781
esv2668678 CNV deletion 23128226
esv26740 CNV loss 19812545
esv2719677 CNV deletion 23290073
esv2719678 CNV deletion 23290073
esv3305113 CNV mobile element insertion 20981092
esv3426353 CNV insertion 20981092
esv3589821 CNV loss 21293372
nsv1134831 CNV deletion 24896259
nsv2608 CNV insertion 18451855
nsv469449 CNV loss 19166990
nsv512767 CNV insertion 21212237
nsv527025 CNV loss 19592680
nsv528398 CNV gain 19592680
nsv580972 CNV loss 21841781
nsv833403 CNV gain 17160897
nsv961382 CNV duplication 23825009

Variation tolerance for LPIN1 Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.95; 89.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPIN1 Gene

Human Gene Mutation Database (HGMD)
LPIN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPIN1 Gene

Disorders for LPIN1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for LPIN1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search LPIN1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LPIN1_HUMAN
  • Myoglobinuria, acute recurrent, autosomal recessive (ARARM) [MIM:268200]: Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness and followed by excretion of myoglobin in the urine. Renal failure may occasionally occur. {ECO:0000269 PubMed:18817903}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LPIN1

Genetic Association Database (GAD)
LPIN1
Human Genome Epidemiology (HuGE) Navigator
LPIN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPIN1
genes like me logo Genes that share disorders with LPIN1: view

No data available for Genatlas for LPIN1 Gene

Publications for LPIN1 Gene

  1. The associations of LPIN1 gene expression in adipose tissue with metabolic phenotypes in the Chinese population. (PMID: 19543209) Chang Y.C. … Chuang L.M. (Obesity (Silver Spring) 2010) 3 22 46 64
  2. Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes of the metabolic syndrome in humans. (PMID: 17940119) Wiedmann S. … Baessler A. (Diabetes 2008) 3 22 46 64
  3. Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men. (PMID: 18437145) Ong K.L. … Cheung B.M. (Am. J. Hypertens. 2008) 3 22 46 64
  4. Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations. (PMID: 18591397) Fawcett K.A. … Barroso I. (Diabetes 2008) 3 22 46 64
  5. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. (PMID: 11138012) PActerfy M. … Reue K. (Nat. Genet. 2001) 2 3 22 64

Products for LPIN1 Gene

Sources for LPIN1 Gene

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