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LPHN3 Gene

protein-coding   GIFtS: 57
GCID: GC04P062070

Latrophilin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Latrophilin 31 2     Latrophilin Homolog 3 (Cow)2
Calcium-Independent Alpha-Latrotoxin Receptor 32 3     latrophilin-32
CIRL-32 3     Lectomedin 32
LEC32 3     KIAA07683
CIRL32     Lectomedin-33

External Ids:    HGNC: 209741   Entrez Gene: 232842   Ensembl: ENSG000001504717   UniProtKB: Q9HAR23   

Export aliases for LPHN3 gene to outside databases

Previous GC identifers: GC04P062005 GC04P061896 GC04P058271


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LPHN3 Gene:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may
function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous
proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in
two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to
the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. (provided by RefSeq,
Jul 2008)

GeneCards Summary for LPHN3 Gene:
LPHN3 (latrophilin 3) is a protein-coding gene. Diseases associated with LPHN3 include sialuria, and brain ischemia. GO annotations related to this gene include carbohydrate binding and G-protein coupled receptor activity. An important paralog of this gene is GPR97.

Gene Wiki entry for LPHN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LPHN3 gene promoter:
         HOXA9   SRF   LHX3b/Lhx3b   Pbx1a   SRF (504 AA)   S8   Nkx6-1   LHX3a/Lhx3a   RSRFC4   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPHN3 promoter sequence
   Search Chromatin IP Primers for LPHN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LPHN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.1   Ensembl cytogenetic band:  4q13.1   HGNC cytogenetic band: 4q13.1

LPHN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPHN3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P062070:  view genomic region     (about GC identifiers)

Start:
62,066,976 bp from pter      End:
62,944,053 bp from pter
Size:
877,078 bases      Orientation:
plus strand

1 alternative location:
Chr4+,NW_003315916 22,525-108,079     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LPHN3_HUMAN, Q9HAR2 (See protein sequence)
Recommended Name: Latrophilin-3 precursor  
Size: 1447 amino acids; 161812 Da
Subunit: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a
seven-transmembrane moiety (p85) (By similarity)
Sequence caution: Sequence=BAA91375.1; Type=Erroneous initiation;
Secondary accessions: O94867 Q9NWK5
Alternative splicing: 3 isoforms:  Q9HAR2-1   Q9HAR2-2   Q9HAR2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LPHN3: NX_Q9HAR2

Explore proteomics data for LPHN3 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (By
    similarity)1
  • Glycosylation2 at Asn93, Ser410, Ser423, Asn464, Asn549, Asn746, Asn759, Asn804, Asn830, Asn1076
  • Modification sites at PhosphoSitePlus

  • See LPHN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056051.2  
    ENSEMBL proteins: 
     ENSP00000423388   ENSP00000422533   ENSP00000423787   ENSP00000425033   ENSP00000424120  
     ENSP00000421476   ENSP00000424030   ENSP00000421372   ENSP00000425201   ENSP00000423434  
     ENSP00000421627   ENSP00000420931   ENSP00000425884   ENSP00000424258   ENSP00000424402  
     ENSP00000439831  

    LPHN3 Human Recombinant Protein Products:

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    LPHN3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: LPHN3
    Adhesion Class GPCRs

    Selected InterPro protein domains (see all 11):
     IPR015630 GPCR_2_latrophilin3
     IPR017983 GPCR_2_secretin-like_CS
     IPR000922 Lectin_gal-bd_dom
     IPR003112 Olfac-like
     IPR001879 GPCR_2_extracellular_dom

    Graphical View of Domain Structure for InterPro Entry Q9HAR2

    ProtoNet protein and cluster: Q9HAR2

    5 Blocks protein domains:
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB000922 D-galactoside/L-rhamnose binding SUEL lectin domain
    IPB003112 Olfactomedin-like
    IPB003924 Latrophilin receptor signature


    UniProtKB/Swiss-Prot: LPHN3_HUMAN, Q9HAR2
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 GPS domain
    Similarity: Contains 1 olfactomedin-like domain
    Similarity: Contains 1 SUEL-type lectin domain


    LPHN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity NAS10994649
    GO:0005515protein binding ----
    GO:0030246carbohydrate binding IEA--
         
    LPHN3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lphn3):
     behavior/neurological  homeostasis/metabolism  nervous system 

    LPHN3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LPHN3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LPHN3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LPHN3

    miRNA
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    miRTarBase miRNAs that target LPHN3:
    hsa-mir-20a-5p (MIRT050534)

    Block miRNA regulation of human, mouse, rat LPHN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LPHN3 (see all 29):
    hsa-miR-30c hsa-miR-142-5p hsa-miR-323-3p hsa-miR-3146 hsa-miR-449c* hsa-miR-331-3p hsa-miR-30d hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidLPHN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LPHN3
    Predesigned siRNA for gene silencing in human, mouse, rat LPHN3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LPHN3

    Clone
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    OriGene clones in human, mouse for LPHN3 (see all 16)
    OriGene ORF clones in mouse, rat for LPHN3
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    GenScript: all cDNA clones in your preferred vector: LPHN3 (NM_015236)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPHN3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LPHN3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LPHN3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPHN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LPHN3_HUMAN, Q9HAR2: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    lysosome1
    nucleus1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS10994649

    LPHN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LPHN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GPCRs, Other
    GPCRs, Other
    2GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like


    2 BioSystems Pathways for LPHN3
        GPCRs, Other
    GPCRs, Class B Secretin-like


        Pathway & Disease-focused RT2 Profiler PCR Array including LPHN3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LPHN3

    2 Interacting proteins for LPHN3 (Q9HAR23) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319463I2D: score=1 
    ZNF24P170283I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway NAS10994649
    GO:0007218neuropeptide signaling pathway IEA--

    LPHN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LPHN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LPHN3 gene: 
    NM_015236.4  

    Unigene Clusters for LPHN3:

    Latrophilin 3
    Hs.28391  [show with all ESTs], Hs.570770  [show with all ESTs]
    Unigene Representative Sequences: AK094703, NM_015236
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000512091(uc010ihg.1 uc003hcq.4) ENST00000509779 ENST00000514591(uc010ihh.3 uc003hct.3)
    ENST00000509896 ENST00000511324 ENST00000506700 ENST00000507164 ENST00000508693
    ENST00000507625 ENST00000514157 ENST00000504896 ENST00000508946 ENST00000506720
    ENST00000506746 ENST00000514996(uc003hcs.1) ENST00000509089 ENST00000502815
    ENST00000508078
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LPHN3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LPHN3 (see all 29):
    hsa-miR-30c hsa-miR-142-5p hsa-miR-323-3p hsa-miR-3146 hsa-miR-449c* hsa-miR-331-3p hsa-miR-30d hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidLPHN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LPHN3
    Predesigned siRNA for gene silencing in human, mouse, rat LPHN3
    Clone
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    OriGene clones in human, mouse for LPHN3 (see all 16)
    OriGene ORF clones in mouse, rat for LPHN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LPHN3 (NM_015236)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPHN3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LPHN3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LPHN3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LPHN3
      QuantiTect SYBR Green Assays in human, mouse, rat LPHN3
      QuantiFast Probe-based Assays in human, mouse, rat LPHN3

    Additional mRNA sequence: 

    AB018311.1 AK000781.1 AK294689.1 AK299651.1 AK309793.1 

    9 DOTS entries:

    DT.100748080  DT.117654  DT.97779660  DT.117652  DT.121239694  DT.405655  DT.446829  DT.91990660 
    DT.99993089 

    Selected AceView cDNA sequences (see all 110):

    AI266046 BF438632 AA127360 Z39855 AA236896 AB018311 F02089 AK000781 
    AA548609 AI126183 AW263287 W92581 BM673830 AI018592 Z43013 Z43790 
    AL119108 BM723489 H86115 BQ771508 BG219251 AV723351 BE645460 H85977 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LPHN3 expression in normal human tissues (normalized intensities)      LPHN3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTACAAAC
    LPHN3 Expression
    About this image


    LPHN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
    LPHN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LPHN3 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.28391 Hs.570770
        Pathway & Disease-focused RT2 Profiler PCR Array including LPHN3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPHN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LPHN3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lphn31 , 5 latrophilin 31, 5 89.97(n)1
    97.18(a)1
      5 (42.62 cM)5
    3193871  NM_198702.21  NP_941991.11 
     810201385 
    chicken
    (Gallus gallus)
    Aves LPHN31 latrophilin 3 82.77(n)
    92.46(a)
      422616  XM_004941142.1  XP_004941199.1 
    lizard
    (Anolis carolinensis)
    Reptilia LPHN36
    latrophilin 3
    96(a)
    1 ↔ 1
    4(139029033-139165763)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004980691 latrophilin-3-like 76.18(n)
    83.91(a)
      100498069  XM_004911437.1  XP_004911494.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj36g072 Transcribed sequence with moderate similarity to protein more 71.33(n)    BI981892.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lat-16
    Protein LAT-1, isoform b (lat-1) mRNA, complete cd...
    29(a)
    1 → many
    II(8896841-8908653) WBGene00002251


    ENSEMBL Gene Tree for LPHN3 (if available)
    TreeFam Gene Tree for LPHN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LPHN3 gene
    GPR972  CD972  ELTD12  LPHN22  LPHN12  GPR1142  EMR12  EMR22  
    GPR1332  GPR1122  GPR1442  EMR32  GPR562  GPR1262  GPR642  
    14 SIMAP similar genes for LPHN3 using alignment to 16 protein entries:     LPHN3_HUMAN (see all proteins):
    LPHH1    LPHN1    LPHN2    ELTD1    EMR4P    FLJ00015
    FLJ00046    BAI3    MYOC    OLFM1    OLFM2    EMR3
    FLJ00237    OLFM3

    LPHN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LPHN3 (see all 10951)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100137931,2
    C,H--58649949(+) ATTTTG/TTTTTT 1 -- int10--------
    rs1901166191,2
    --62360898(+) AGGTTA/GTCTGG 1 -- us2k10--------
    rs1817150831,2
    --62360928(+) AACTAC/TCATGC 1 -- us2k10--------
    rs1388572031,2
    C--62360995(+) AAGACG/TTTGGT 1 -- us2k10--------
    rs1872948221,2
    --62361044(+) CAGTAA/GACAAT 1 -- us2k10--------
    rs749188571,2
    C--62361132(+) AAGACA/CAAAAA 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1908959021,2
    --62361135(+) ACAAAA/GAAAAG 1 -- us2k10--------
    rs76725491,2
    C,F--62361138(+) AAAAAG/Aagaaa 1 -- us2k1 trp31Minor allele frequency- A:0.50WA 2
    rs1458130081,2
    C--62361190(+) GGAGG-/AGGA  
            
    AGGAA
    1 -- us2k10--------
    rs787715701,2
    C,F--62361217(+) GGGAAG/AGGAAG 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for LPHN3 (62066976 - 62316976 bp, first 250kb of LPHN3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LPHN3 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727704CNV Deletion23290073
    esv2671240CNV Deletion23128226
    nsv821451CNV Deletion20802225
    esv1721979CNV Deletion17803354
    esv273414CNV Insertion20981092
    esv268798CNV Insertion20981092
    esv268599CNV Insertion20981092
    esv270718CNV Insertion20981092
    nsv507170CNV Insertion20534489
    nsv829949CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    8 diseases for LPHN3:    About MalaCards
    sialuria    brain ischemia    attention deficit hyperactivity disorder    narcolepsy
    ischemia    atherosclerosis    schizophrenia    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for LPHN3:
    Sialuria     Attention deficit hyperactivity disorder

    LPHN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LPHN3
    Human Genome Epidemiology (HuGE) Navigator: LPHN3 (7 documents)

    Export disorders for LPHN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LPHN3 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with LPHN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Screening of human LPHN3 for variants with a potential impact on ADHD susceptibility. (PubMed id 21184580)1, 2 DomenAc S....Muenke M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
    2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)1, 4 McClay J.L....van den Oord E.J. (Neuropsychopharmacology 2011)
    3. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. (PubMed id 20522523)1, 4 KasperaviciAte D....Sisodiya S.M. (Brain 2010)
    4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. (PubMed id 20157310)1, 4 Arcos-Burgos M....Muenke M. (Mol. Psychiatry 2010)
    7. Genome-wide association study of biochemical traits in Korcula Island, Croatia. (PubMed id 19260141)1, 4 Zemunik T....Rudan I. (Croat. Med. J. 2009)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. A family of heptahelical receptors with adhesion-like domains: a marriage between two super families. (PubMed id 10994649)1, 3 Hayflick J.S. (J. Recept. Signal Transduct. Res. 2000)
    10. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23284 HGNC: 20974 AceView: LPHN3 Ensembl:ENSG00000150471 euGenes: HUgn23284
    ECgene: LPHN3 H-InvDB: LPHN3

    (According to HUGE)
    About This Section

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    HUGE: KIAA0768

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LPHN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LPHN3 gene:
    Search GeneIP for patents involving LPHN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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