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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LPHN2 Gene

protein-coding   GIFtS: 58
GCID: GC01P081771

Latrophilin 2

(Previous name: latrophilin 1)
(Previous symbol: LPHH1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Latrophilin 21 2     CIRL22
LPHH11 2 3 5     CL22
Latrophilin 11 2     Latrophilin Homolog 2 (Cow)2
Calcium-Independent Alpha-Latrotoxin Receptor 22 3     latrophilin-22
Latrophilin Homolog 12 3     lectomedin-12
CIRL-22 3     KIAA07863
LEC12 3     Lectomedin-13

External Ids:    HGNC: 185821   Entrez Gene: 232662   Ensembl: ENSG000001171147   OMIM: 6070185   UniProtKB: O954903   

Export aliases for LPHN2 gene to outside databases

Previous GC identifers: GC01P081455 GC01P081588 GC01P081688 GC01P081877 GC01P080397


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LPHN2 Gene:
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may
function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous
proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in
two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to
the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several
transcript variants have been described, the biological validity of only one has been determined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for LPHN2 Gene: 
LPHN2 (latrophilin 2) is a protein-coding gene. Diseases associated with LPHN2 include dermatophytosis, and pituitary adenoma. GO annotations related to this gene include G-protein coupled receptor activity and latrotoxin receptor activity. An important paralog of this gene is GPR97.

UniProtKB/Swiss-Prot: LPHN2_HUMAN, O95490
Function: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in
black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor
propably implicated in the regulation of exocytosis (By similarity)

Gene Wiki entry for LPHN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LPHN2 gene promoter:
         Egr-3   Sox5   p300   FOXO3   Nkx2-5   YY1   E47   CREB   deltaCREB   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPHN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LPHN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPHN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

LPHN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPHN2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P081771:  view genomic region     (about GC identifiers)

Start:
81,771,845 bp from pter      End:
82,458,120 bp from pter
Size:
686,276 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LPHN2_HUMAN, O95490 (See protein sequence)
Recommended Name: Latrophilin-2 precursor  
Size: 1459 amino acids; 163349 Da
Subunit: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a
seven-transmembrane moiety (p85) (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAI22406.1; Type=Erroneous gene model prediction;
Secondary accessions: A5XEI2 B1ALT8 B1ALT9 B1ALU0 B1ALU2 B1ALU4 B1ALU5 B1ALU6 O94882 Q5VX76
Q9UKY5 Q9UKY6
Alternative splicing: 7 isoforms:  O95490-1   O95490-2   O95490-3   O95490-4   O95490-5   O95490-6   O95490-7   (No experimental confirmation)

Explore the universe of human proteins at neXtProt for LPHN2: NX_O95490

Explore proteomics data for LPHN2 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95490

  • LPHN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LPHN2 Protein Expression
    REFSEQ proteins: NP_036434.1  
    ENSEMBL proteins: 
     ENSP00000359756   ENSP00000359762   ENSP00000359760   ENSP00000359758   ENSP00000359763  
     ENSP00000359765   ENSP00000353006   ENSP00000359750   ENSP00000359748   ENSP00000322270  
     ENSP00000397740   ENSP00000385853   ENSP00000359752   ENSP00000378344   ENSP00000271029  
     ENSP00000337306  

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    Cloud-Clone Corp. Proteins for LPHN2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS10030676

    LPHN2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRBO: GPCR / Class B : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: LPHN2 
    Adhesion Class GPCRs

    5/10 InterPro protein domains (see all 10):
     IPR017983 GPCR_2_secretin-like_CS
     IPR000922 Lectin_gal-bd_dom
     IPR003112 Olfac-like
     IPR001879 GPCR_2_extracellular_dom
     IPR003334 GPCR_2_latrophilin_rcpt_C

    Graphical View of Domain Structure for InterPro Entry O95490

    ProtoNet protein and cluster: O95490

    5/6 Blocks protein domains (see all 6):
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB000922 D-galactoside/L-rhamnose binding SUEL lectin domain
    IPB002088 Protein prenyltransferase
    IPB003112 Olfactomedin-like


    UniProtKB/Swiss-Prot: LPHN2_HUMAN, O95490
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 1 GPS domain
    Similarity: Contains 1 olfactomedin-like domain
    Similarity: Contains 1 SUEL-type lectin domain


    LPHN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPHN2_HUMAN, O95490
    Function: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in
    black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor
    propably implicated in the regulation of exocytosis (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005515protein binding ----
    GO:0016524latrotoxin receptor activity NAS10030676
    GO:0030246carbohydrate binding IEA--
         
    LPHN2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lphn2):
     behavior/neurological  mortality/aging 

    LPHN2 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidLPHN2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LPHN2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GPCRs, Other
    GPCRs, Other
    2GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like


    2 BioSystems Pathways for LPHN2
        GPCRs, Other
    GPCRs, Class B Secretin-like


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LPHN2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for LPHN2 (O954902, 3 ENSP000003222704) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHANK1Q9Y5662, 3, ENSP000002934414MINT-72956 I2D: score=3 STRING: ENSP00000293441
    SHANK2Q9UPX83, ENSP000003451934I2D: score=1 STRING: ENSP00000345193
    BECN1Q144573I2D: score=1 
    HDAC1ENSP000003626494STRING: ENSP00000362649
    NCK1ENSP000002889864STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway NAS10030676
    GO:0007218neuropeptide signaling pathway IEA--

    LPHN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LPHN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LPHN2

    1 HMDB Compound for LPHN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 Novoseek inferred chemical compound relationships for LPHN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-latrotoxin 81.6 1 9830014 (1)
    abscisic acid 57.7 2 9286105 (1), 18476867 (1)
    dexamethasone 14 2 15695450 (1)

    Search CenterWatch for drugs/clinical trials and news about LPHN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LPHN2 gene: 
    NM_012302.2  

    Unigene Clusters for LPHN2:

    Latrophilin 2
    Hs.24212  [show with all ESTs], Hs.649282  [show with all ESTs]
    Unigene Representative Sequences: NM_012302, BC031321
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000473719 ENST00000370721 ENST00000370727(uc009wce.1) ENST00000370725
    ENST00000370723 ENST00000370728 ENST00000370730 ENST00000492666 ENST00000469377(uc001dis.3)
    ENST00000359929(uc001dit.4) ENST00000370715 ENST00000370713 ENST00000319517
    ENST00000449420 ENST00000468283 ENST00000402328 ENST00000464775 ENST00000472424

    miRNA
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    8/88 QIAGEN miScript miRNA Assays for microRNAs that regulate LPHN2 (see all 88):
    hsa-miR-140-5p hsa-miR-300 hsa-miR-15a hsa-miR-1245 hsa-miR-374a hsa-miR-629* hsa-miR-298 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidLPHN2 3' UTR sequence
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    Additional mRNA sequence: BC031321.1 

    17 DOTS entries:

    DT.100789911  DT.95340465  DT.92432445  DT.453883  DT.100789916  DT.100716367  DT.97842650  DT.91893928 
    DT.95144303  DT.100789908  DT.100789915  DT.40129296  DT.121456452  DT.121456499  DT.95268989  DT.121456519 
    DT.99928470 

    24/174 AceView cDNA sequences (see all 174):

    CR596199 AU133359 AI889699 Z40660 CA390097 BQ022963 AA401286 BP335760 
    BP337650 AF104939 BM920769 AA227775 NM_012302 AI640464 AB018329 AA652670 
    AA236634 AU133021 AW469277 AW078864 BM969115 AA903264 AL541796 CB119915 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for LPHN2 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^
    SP1:                          -                                                           -                                                                     
    SP2:                          -                                                           -                                                                     
    SP3:                    -     -                                                           -                                                                     
    SP4:                          -                                                           -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28 ^ 29a · 29b · 29c · 29d
    SP1:  -                       -     -     -                 -                                 
    SP2:  -                       -     -     -     -     -     -     -                           
    SP3:  -                       -     -     -     -     -     -     -                           
    SP4:  -                 -     -     -     -     -     -     -     -                           
    SP5:  -                       -           -     -     -     -     -                           


    ECgene alternative splicing isoforms for LPHN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LPHN2 expression in normal human tissues (normalized intensities)      LPHN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTGAGAG
    LPHN2 Expression
    About this image


    LPHN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Intestine (Gastrointestinal Tract)
             SMALL INTESTINE   
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Endothelium (Cardiovascular System)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See LPHN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LPHN2

    SOURCE GeneReport for Unigene clusters: Hs.24212 Hs.649282

    UniProtKB/Swiss-Prot: LPHN2_HUMAN, O95490
    Tissue specificity: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell
    lines, apparently elevated in some lines and absent or markedly reduced in others

        SABiosciences Expression via Pathway-Focused PCR Array including LPHN2: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LPHN2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lphn21 , 5 latrophilin 21, 5 87.41(n)1
    95.79(a)1
      3 (74.10 cM)5
    996331  NM_001081298.11  NP_001074767.11 
     1488155865 
    chicken
    (Gallus gallus)
    Aves LPHN21 latrophilin 2 85.97(n)
    94.08(a)
      424545  NM_001190477.1  NP_001177406.1 
    lizard
    (Anolis carolinensis)
    Reptilia LPHN26
    latrophilin 2
    91(a)
    1 ↔ 1
    GL343194.1(7459226-7671974)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167782 Xenopus laevis transcribed sequence with strong similarity more 85.15(n)    BQ734821.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb72a082 wufb72a08 78.23(n)   322731  BG985744.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cirl6
    Cirl
    15(a)
    1 → many
    2R(4502227-4512708)
    worm
    (Caenorhabditis elegans)
    Secernentea lat-11 Protein LAT-1 44.51(n)
    31.94(a)
      174419  NM_182149.3  NP_871949.1 


    ENSEMBL Gene Tree for LPHN2 (if available)
    TreeFam Gene Tree for LPHN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LPHN2 gene
    GPR972  CD972  ELTD12  LPHN12  GPR1142  EMR12  EMR22  LPHN32  
    GPR1332  GPR1122  GPR1442  GPR562  EMR32  GPR1262  GPR642  
    13 SIMAP similar genes for LPHN2 using alignment to 5 protein entries:     LPHN2_HUMAN (see all proteins):
    LPHH1    LPHN1    LPHN3    EMR4P    ELTD1    OLFM1
    FLJ00015    MYOC    FLJ00046    FLJ00237    OLFM2    OLFM3
    EMR3

    LPHN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3780 SNPs in LPHN2 are shown (see all 3780)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113386951,2
    C,F--82265574(+) GCAAT-/AAAAAA 1 -- us2k1 trp33Minor allele frequency- A:0.33NA CSA 6
    rs361171741,2
    --82271416(+) TGGTTA/TAAAAA 1 -- int10--------
    rs3731936801,2
    C--82271416(+) GTGGT-/AAAAAA 1 -- int10--------
    rs57756321,2
    C--82276104(-) TGGTA-/ACCAGT 1 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs1871352621,2
    --82283812(+) AAGATC/TTGAAA 1 -- us2k10--------
    rs38114681,2
    C,F,A,H--82283896(-) CAAAAA/CAGGAG 1 -- us2k1 trp314Minor allele frequency- C:0.22EA NS NA WA CSA 2198
    rs1923143571,2
    C--82284094(+) TTACTA/GAGCTC 1 -- us2k10--------
    rs757995821,2
    C--82284189(+) AATGG-/G/TYCCCA 1 -- us2k10--------
    rs38410691,2
    C--82284190(-) CTGGGC/-ACCAT 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs745297931,2
    --82284190(+) ATGGTC/G/TCCCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LPHN2 (81771845 - 82021845 bp, first 250kb of LPHN2)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LPHN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659412CNV Deletion23128226
    esv271483CNV Insertion20981092
    esv272877CNV Insertion20981092
    nsv437226CNV Loss16327808
    nsv437590CNV Loss16327808

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607018    OMIM disorders: --

    5 diseases for LPHN2:    About MalaCards
    dermatophytosis    pituitary adenoma    adenoma    breast cancer
    neuronitis


    LPHN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LPHN2

    Export disorders for LPHN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LPHN2 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with LPHN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. (PubMed id 10760572)1, 2, 3 White G.R.M.... Heighway J. (2000)
    2. Isolation and characterisation of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. (PubMed id 10030676)1, 2, 9 White G.R.M.... Heighway J. (1998)
    3. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)1, 4 Benjamin E.J....Vasan R.S. (2007)
    4. Discovery of tissue-specific exons using comprehensive human exon microarrays. (PubMed id 17456239)1, 2 Clark T.A....Blume J.E. (2007)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
    7. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (2013)
    8. A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. (PubMed id 22832960)1 Service S.K....Freimer N.B. (2012)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23266 HGNC: 18582 AceView: LPHN2 Ensembl:ENSG00000117114 euGenes: HUgn23266
    ECgene: LPHN2 H-InvDB: LPHN2

    (According to HUGE)
    About This Section
    HUGE: KIAA0786

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LPHN2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LPHN2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LPHN2 gene:
    Search GeneIP for patents involving LPHN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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