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Aliases for LPGAT1 Gene

Aliases for LPGAT1 Gene

  • Lysophosphatidylglycerol Acyltransferase 1 2 3 5
  • Family With Sequence Similarity 34, Member A 2 3
  • FAM34A 3 4
  • EC 2.3.1.- 4
  • KIAA0205 4
  • FAM34A1 3
  • NET8 3

External Ids for LPGAT1 Gene

Previous HGNC Symbols for LPGAT1 Gene

  • FAM34A

Previous GeneCards Identifiers for LPGAT1 Gene

  • GC01M208307
  • GC01M209983
  • GC01M211916
  • GC01M182594

Summaries for LPGAT1 Gene

Entrez Gene Summary for LPGAT1 Gene

  • This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for LPGAT1 Gene

LPGAT1 (Lysophosphatidylglycerol Acyltransferase 1) is a Protein Coding gene. Diseases associated with LPGAT1 include active peptic ulcer disease. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include transferase activity, transferring acyl groups.

UniProtKB/Swiss-Prot for LPGAT1 Gene

  • Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPGAT1 Gene

Genomics for LPGAT1 Gene

Regulatory Elements for LPGAT1 Gene

Promoters for LPGAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LPGAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPGAT1 Gene

Chromosome:
1
Start:
211,743,457 bp from pter
End:
211,830,832 bp from pter
Size:
87,376 bases
Orientation:
Minus strand

Genomic View for LPGAT1 Gene

Genes around LPGAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPGAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPGAT1 Gene

Proteins for LPGAT1 Gene

  • Protein details for LPGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92604-LGAT1_HUMAN
    Recommended name:
    Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
    Protein Accession:
    Q92604
    Secondary Accessions:
    • Q53YL2

    Protein attributes for LPGAT1 Gene

    Size:
    370 amino acids
    Molecular mass:
    43089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13196.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LPGAT1 Gene

Proteomics data for LPGAT1 Gene at MOPED

Post-translational modifications for LPGAT1 Gene

  • Ubiquitination at Lys 201
  • Modification sites at PhosphoSitePlus

Other Protein References for LPGAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LPGAT1 Gene

Domains & Families for LPGAT1 Gene

Protein Domains for LPGAT1 Gene

Suggested Antigen Peptide Sequences for LPGAT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92604

UniProtKB/Swiss-Prot:

LGAT1_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LPGAT1: view

No data available for Gene Families for LPGAT1 Gene

Function for LPGAT1 Gene

Molecular function for LPGAT1 Gene

UniProtKB/Swiss-Prot Function:
Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.

Enzyme Numbers (IUBMB) for LPGAT1 Gene

Gene Ontology (GO) - Molecular Function for LPGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with LPGAT1: view
genes like me logo Genes that share phenotypes with LPGAT1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LPGAT1 Gene

Localization for LPGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPGAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPGAT1 Gene COMPARTMENTS Subcellular localization image for LPGAT1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
plasma membrane 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LPGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LPGAT1: view

Pathways & Interactions for LPGAT1 Gene

genes like me logo Genes that share pathways with LPGAT1: view

Pathways by source for LPGAT1 Gene

Gene Ontology (GO) - Biological Process for LPGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LPGAT1: view

No data available for SIGNOR curated interactions for LPGAT1 Gene

Drugs & Compounds for LPGAT1 Gene

(131) Additional Compounds for LPGAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate
genes like me logo Genes that share compounds with LPGAT1: view

Transcripts for LPGAT1 Gene

Unigene Clusters for LPGAT1 Gene

Lysophosphatidylglycerol acyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPGAT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:

Relevant External Links for LPGAT1 Gene

GeneLoc Exon Structure for
LPGAT1
ECgene alternative splicing isoforms for
LPGAT1

Expression for LPGAT1 Gene

mRNA expression in normal human tissues for LPGAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LPGAT1 Gene

This gene is overexpressed in Fetal gut (18.3), Islet of Langerhans (10.4), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LPGAT1 Gene



SOURCE GeneReport for Unigene cluster for LPGAT1 Gene Hs.744851

mRNA Expression by UniProt/SwissProt for LPGAT1 Gene

Q92604-LGAT1_HUMAN
Tissue specificity: Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon.
genes like me logo Genes that share expression patterns with LPGAT1: view

Protein tissue co-expression partners for LPGAT1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LPGAT1 Gene

Orthologs for LPGAT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LPGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPGAT1 35
  • 92.79 (n)
  • 91.08 (a)
LPGAT1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPGAT1 35
  • 93.69 (n)
  • 92.43 (a)
LPGAT1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpgat1 35
  • 89.55 (n)
  • 90 (a)
Lpgat1 16
Lpgat1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPGAT1 35
  • 99.91 (n)
  • 99.73 (a)
LPGAT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpgat1 35
  • 89.28 (n)
  • 89.19 (a)
oppossum
(Monodelphis domestica)
Mammalia LPGAT1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPGAT1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPGAT1 35
  • 79.64 (n)
  • 79.46 (a)
LPGAT1 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPGAT1 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68966 35
zebrafish
(Danio rerio)
Actinopterygii lpgat1 35
  • 66.94 (n)
  • 69.73 (a)
lpgat1 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002482 35
  • 52.14 (n)
  • 45.91 (a)
worm
(Caenorhabditis elegans)
Secernentea acl-14 35
  • 49.13 (n)
  • 39.53 (a)
acl-12 36
  • 25 (a)
OneToMany
acl-13 36
  • 23 (a)
OneToMany
acl-14 36
  • 30 (a)
OneToMany
Species with no ortholog for LPGAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LPGAT1 Gene

ENSEMBL:
Gene Tree for LPGAT1 (if available)
TreeFam:
Gene Tree for LPGAT1 (if available)

Paralogs for LPGAT1 Gene

Pseudogenes.org Pseudogenes for LPGAT1 Gene

genes like me logo Genes that share paralogs with LPGAT1: view

No data available for Paralogs for LPGAT1 Gene

Variants for LPGAT1 Gene

Sequence variations from dbSNP and Humsavar for LPGAT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3292 -- 211,825,526(+) TTATC(C/T)TAGAT intron-variant
rs14728 -- 211,745,234(-) CCTTT(C/T)TTTGT utr-variant-3-prime
rs1065607 -- 211,799,433(-) GCCTC(A/G)TTTTC intron-variant
rs1126968 -- 211,748,672(-) GGTCT(C/T)ACTCT utr-variant-3-prime
rs1042928 -- 211,746,935(-) CTTGG(C/T)ATTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LPGAT1 Gene

Variant ID Type Subtype PubMed ID
nsv826553 CNV Loss 20364138
esv2665423 CNV Deletion 23128226
esv273213 CNV Insertion 20981092
esv2722406 CNV Deletion 23290073

Variation tolerance for LPGAT1 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPGAT1 Gene

HapMap Linkage Disequilibrium report
LPGAT1
Human Gene Mutation Database (HGMD)
LPGAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPGAT1 Gene

Disorders for LPGAT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LPGAT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
active peptic ulcer disease
  • gi bleeding
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LPGAT1

Genetic Association Database (GAD)
LPGAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPGAT1
genes like me logo Genes that share disorders with LPGAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPGAT1 Gene

Publications for LPGAT1 Gene

  1. Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase. (PMID: 15485873) Yang Y. … Shi Y. (J. Biol. Chem. 2004) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3
  5. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PMID: 23464991) Scifo E. … Lalowski M. (J. Proteome Res. 2013) 3

Products for LPGAT1 Gene

Sources for LPGAT1 Gene

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