Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LPGAT1 Gene

Aliases for LPGAT1 Gene

  • Lysophosphatidylglycerol Acyltransferase 1 2 3 5
  • Family With Sequence Similarity 34, Member A 2 3
  • FAM34A 3 4
  • Acyl-CoA:Lysophosphatidylglycerol Acyltransferase 1 3
  • EC 2.3.1.- 4
  • KIAA0205 4
  • FAM34A1 3
  • NET8 3

External Ids for LPGAT1 Gene

Previous HGNC Symbols for LPGAT1 Gene

  • FAM34A

Previous GeneCards Identifiers for LPGAT1 Gene

  • GC01M208307
  • GC01M209983
  • GC01M211916
  • GC01M182594

Summaries for LPGAT1 Gene

Entrez Gene Summary for LPGAT1 Gene

  • This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for LPGAT1 Gene

LPGAT1 (Lysophosphatidylglycerol Acyltransferase 1) is a Protein Coding gene. Diseases associated with LPGAT1 include Cardiomyopathy, Dilated, 1D and Active Peptic Ulcer Disease. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include transferase activity, transferring acyl groups.

UniProtKB/Swiss-Prot for LPGAT1 Gene

  • Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.

Additional gene information for LPGAT1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPGAT1 Gene

Genomics for LPGAT1 Gene

Regulatory Elements for LPGAT1 Gene

Enhancers for LPGAT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H211914 1.5 Ensembl ENCODE dbSUPER 20.4 -87.4 -87449 6 PKNOX1 FOXA2 ZFP64 ARID4B YY1 TCF12 FOS ATF7 MCM3 NFIL3 LPGAT1 LOC102723727 SNORA16B TRAF5 ENSG00000212187 ENSG00000229832 INTS7 ENSG00000233626 PIR53279
GH01H211907 1.2 ENCODE dbSUPER 22.3 -79.6 -79607 5 FOXA2 FEZF1 YY1 FOS ATF7 RUNX3 JUNB REST SMARCB1 MAFF LPGAT1 LOC102723727 LOC91548 NEK2 ENSG00000212187 ENSG00000233626 PIR53279
GH01H211901 1 ENCODE dbSUPER 21.9 -72.7 -72742 3 PKNOX1 TAF1 MAX RAD21 YY1 CBX5 ZSCAN5C HNF4G TRIM24 STAT1 LPGAT1 LOC102723727 NEK2 LOC91548 ENSG00000233626 PIR53279
GH01H211783 0.9 ENCODE 20.9 +46.8 46790 1 ELF3 FOXA2 MLX ZFP64 ARID4B RAD21 RARA CREM MIXL1 THAP11 LPGAT1 LOC102723727 RN7SL344P PIR57135
GH01H211927 1.6 Ensembl ENCODE dbSUPER 11.5 -98.6 -98626 3 HDGF FOXA2 ARNT ARID4B FEZF1 DMAP1 YY1 ZNF766 FOS SP5 LOC102723727 RCOR3 LPGAT1 LOC91548 NEK2 SNX25P1 ENSG00000212187 RPL21P28 INTS7 ENSG00000233626
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LPGAT1 on UCSC Golden Path with GeneCards custom track

Promoters for LPGAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019622 532 2201 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 TCF12 ZNF143 ATF7 RUNX3

Genomic Location for LPGAT1 Gene

Chromosome:
1
Start:
211,743,457 bp from pter
End:
211,830,832 bp from pter
Size:
87,376 bases
Orientation:
Minus strand

Genomic View for LPGAT1 Gene

Genes around LPGAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPGAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPGAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPGAT1 Gene

Proteins for LPGAT1 Gene

  • Protein details for LPGAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92604-LGAT1_HUMAN
    Recommended name:
    Acyl-CoA:lysophosphatidylglycerol acyltransferase 1
    Protein Accession:
    Q92604
    Secondary Accessions:
    • Q53YL2

    Protein attributes for LPGAT1 Gene

    Size:
    370 amino acids
    Molecular mass:
    43089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13196.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LPGAT1 Gene

Post-translational modifications for LPGAT1 Gene

  • Ubiquitination at posLast=201201
  • Modification sites at PhosphoSitePlus

Other Protein References for LPGAT1 Gene

No data available for DME Specific Peptides for LPGAT1 Gene

Domains & Families for LPGAT1 Gene

Gene Families for LPGAT1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LPGAT1 Gene

Suggested Antigen Peptide Sequences for LPGAT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92604

UniProtKB/Swiss-Prot:

LGAT1_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LPGAT1: view

Function for LPGAT1 Gene

Molecular function for LPGAT1 Gene

UniProtKB/Swiss-Prot Function:
Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.

Enzyme Numbers (IUBMB) for LPGAT1 Gene

Phenotypes From GWAS Catalog for LPGAT1 Gene

Gene Ontology (GO) - Molecular Function for LPGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with LPGAT1: view
genes like me logo Genes that share phenotypes with LPGAT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LPGAT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LPGAT1 Gene

Localization for LPGAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPGAT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPGAT1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LPGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPGAT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LPGAT1 Gene

Pathways & Interactions for LPGAT1 Gene

genes like me logo Genes that share pathways with LPGAT1: view

Pathways by source for LPGAT1 Gene

Gene Ontology (GO) - Biological Process for LPGAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0036148 phosphatidylglycerol acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with LPGAT1: view

No data available for SIGNOR curated interactions for LPGAT1 Gene

Drugs & Compounds for LPGAT1 Gene

(131) Additional Compounds for LPGAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate
genes like me logo Genes that share compounds with LPGAT1: view

Transcripts for LPGAT1 Gene

Unigene Clusters for LPGAT1 Gene

Lysophosphatidylglycerol acyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LPGAT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LPGAT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:

Relevant External Links for LPGAT1 Gene

GeneLoc Exon Structure for
LPGAT1
ECgene alternative splicing isoforms for
LPGAT1

Expression for LPGAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPGAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LPGAT1 Gene

This gene is overexpressed in Fetal gut (18.3), Islet of Langerhans (10.4), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LPGAT1 Gene



Protein tissue co-expression partners for LPGAT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LPGAT1 Gene:

LPGAT1

SOURCE GeneReport for Unigene cluster for LPGAT1 Gene:

Hs.744851

mRNA Expression by UniProt/SwissProt for LPGAT1 Gene:

Q92604-LGAT1_HUMAN
Tissue specificity: Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon.

Evidence on tissue expression from TISSUES for LPGAT1 Gene

  • Liver(4.3)
  • Bone marrow(4.2)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with LPGAT1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPGAT1 Gene

Orthologs for LPGAT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LPGAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPGAT1 33 34
  • 99.91 (n)
dog
(Canis familiaris)
Mammalia LPGAT1 33 34
  • 93.69 (n)
cow
(Bos Taurus)
Mammalia LPGAT1 33 34
  • 92.79 (n)
mouse
(Mus musculus)
Mammalia Lpgat1 33 16 34
  • 89.55 (n)
rat
(Rattus norvegicus)
Mammalia Lpgat1 33
  • 89.28 (n)
oppossum
(Monodelphis domestica)
Mammalia LPGAT1 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPGAT1 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPGAT1 33 34
  • 79.64 (n)
lizard
(Anolis carolinensis)
Reptilia LPGAT1 34
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68966 33
zebrafish
(Danio rerio)
Actinopterygii lpgat1 33 34
  • 66.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002482 33
  • 52.14 (n)
worm
(Caenorhabditis elegans)
Secernentea acl-14 33 34
  • 49.13 (n)
acl-12 34
  • 25 (a)
OneToMany
acl-13 34
  • 23 (a)
OneToMany
Species where no ortholog for LPGAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LPGAT1 Gene

ENSEMBL:
Gene Tree for LPGAT1 (if available)
TreeFam:
Gene Tree for LPGAT1 (if available)

Paralogs for LPGAT1 Gene

Pseudogenes.org Pseudogenes for LPGAT1 Gene

genes like me logo Genes that share paralogs with LPGAT1: view

No data available for Paralogs for LPGAT1 Gene

Variants for LPGAT1 Gene

Sequence variations from dbSNP and Humsavar for LPGAT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000018648 -- 211,753,312(+) TCCTC(A/G)AACTT intron-variant
rs1000033851 -- 211,776,005(+) AATAA(A/C)TGCCT intron-variant
rs1000054673 -- 211,804,156(+) TAGCC(C/T)CAACC intron-variant
rs1000100030 -- 211,813,675(+) GAGAA(C/T)ATTTT intron-variant
rs1000128492 -- 211,759,668(+) TCCTA(C/T)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPGAT1 Gene

Variant ID Type Subtype PubMed ID
esv2665423 CNV deletion 23128226
esv2722406 CNV deletion 23290073
esv3418118 CNV insertion 20981092
esv3440536 CNV insertion 20981092
esv3546055 CNV deletion 23714750
esv3588735 CNV gain 21293372
esv3588737 CNV loss 21293372
esv3588738 CNV loss 21293372
nsv1068853 CNV deletion 25765185
nsv1137844 CNV deletion 24896259
nsv826553 CNV loss 20364138

Variation tolerance for LPGAT1 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPGAT1 Gene

Human Gene Mutation Database (HGMD)
LPGAT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPGAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPGAT1 Gene

Disorders for LPGAT1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LPGAT1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1d
  • left ventricular noncompaction 6
active peptic ulcer disease
  • gi bleeding
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LPGAT1

Genetic Association Database (GAD)
LPGAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPGAT1
genes like me logo Genes that share disorders with LPGAT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPGAT1 Gene

Publications for LPGAT1 Gene

  1. Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase. (PMID: 15485873) Yang Y … Shi Y (The Journal of biological chemistry 2004) 2 3 4 22 60
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for LPGAT1 Gene

Sources for LPGAT1 Gene

Content
Loading form....