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Aliases for LPCAT4 Gene

Aliases for LPCAT4 Gene

  • Lysophosphatidylcholine Acyltransferase 4 2 3 4 5
  • Lysophosphatidylethanolamine Acyltransferase 2 2 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 7 (Lysophosphatidic Acid Acyltransferase, Eta) 2 3
  • 1-Alkenylglycerophosphoethanolamine O-Acyltransferase 3 4
  • 1-Alkylglycerophosphocholine O-Acetyltransferase 3 4
  • 1-Acylglycerophosphocholine O-Acyltransferase 3 4
  • 1-Acylglycerophosphoserine O-Acyltransferase 3 4
  • 1-AGP Acyltransferase 7 3 4
  • Acyltransferase Like 3 2 3
  • Acyltransferase-Like 3 3 4
  • Plasmalogen Synthase 3 4
  • EC 2.3.1.23 4 63
  • 1-AGPAT 7 3 4
  • AGPAT7 3 4
  • LPEAT2 3 4
  • AYTL3 3 4
  • Acyl-CoA:Lysophosphatidylethanolamine Acyltransferase 2 3
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 7 4
  • PLSC Domain Containing Protein 3
  • EC 2.3.1.121 4
  • EC 2.3.1.n6 4
  • EC 2.3.1.67 4
  • EC 2.3.1.n7 4
  • LPAAT-Eta 3
  • EC 2.3.1 63

External Ids for LPCAT4 Gene

Previous HGNC Symbols for LPCAT4 Gene

  • AYTL3
  • AGPAT7

Previous GeneCards Identifiers for LPCAT4 Gene

  • GC15M032440
  • GC15M034651
  • GC15M011516

Summaries for LPCAT4 Gene

Entrez Gene Summary for LPCAT4 Gene

  • Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]

GeneCards Summary for LPCAT4 Gene

LPCAT4 (Lysophosphatidylcholine Acyltransferase 4) is a Protein Coding gene. Diseases associated with LPCAT4 include endometriosis of ovary. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include calcium ion binding and 1-acylglycerophosphocholine O-acyltransferase activity. An important paralog of this gene is LPCAT1.

UniProtKB/Swiss-Prot for LPCAT4 Gene

  • Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPCAT4 Gene

Genomics for LPCAT4 Gene

Regulatory Elements for LPCAT4 Gene

Promoters for LPCAT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LPCAT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPCAT4 Gene

Chromosome:
15
Start:
34,358,618 bp from pter
End:
34,367,278 bp from pter
Size:
8,661 bases
Orientation:
Minus strand

Genomic View for LPCAT4 Gene

Genes around LPCAT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPCAT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPCAT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPCAT4 Gene

Proteins for LPCAT4 Gene

  • Protein details for LPCAT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q643R3-LPCT4_HUMAN
    Recommended name:
    Lysophospholipid acyltransferase LPCAT4
    Protein Accession:
    Q643R3
    Secondary Accessions:
    • A8K2K8
    • O43412
    • Q7Z4P4
    • Q8IUL7
    • Q8TB38

    Protein attributes for LPCAT4 Gene

    Size:
    524 amino acids
    Molecular mass:
    57219 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC19156.1; Type=Frameshift; Positions=328; Evidence={ECO:0000305}; Sequence=AAC19156.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAN33178.1; Type=Frameshift; Positions=198; Evidence={ECO:0000305}; Sequence=AAP97722.1; Type=Frameshift; Positions=188, 198; Evidence={ECO:0000305};

neXtProt entry for LPCAT4 Gene

Proteomics data for LPCAT4 Gene at MOPED

Selected DME Specific Peptides for LPCAT4 Gene

Post-translational modifications for LPCAT4 Gene

Other Protein References for LPCAT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LPCAT4 Gene

Gene Families for LPCAT4 Gene

Protein Domains for LPCAT4 Gene

Suggested Antigen Peptide Sequences for LPCAT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q643R3

UniProtKB/Swiss-Prot:

LPCT4_HUMAN :
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LPCAT4: view

Function for LPCAT4 Gene

Molecular function for LPCAT4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=80 uM for lysophosphatidylethanolamine {ECO:0000269 PubMed:18458083}; KM=20 uM for oleoyl-CoA {ECO:0000269 PubMed:18458083}; Vmax=270 pmol/min/mg enzyme with lysophosphatidylethanolamine and oleoyl-CoA as substrates {ECO:0000269 PubMed:18458083};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylserine.
UniProtKB/Swiss-Prot Function:
Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors.

Enzyme Numbers (IUBMB) for LPCAT4 Gene

Gene Ontology (GO) - Molecular Function for LPCAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with LPCAT4: view
genes like me logo Genes that share phenotypes with LPCAT4: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LPCAT4 Gene

Localization for LPCAT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPCAT4 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPCAT4 Gene COMPARTMENTS Subcellular localization image for LPCAT4 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for LPCAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LPCAT4: view

Pathways & Interactions for LPCAT4 Gene

genes like me logo Genes that share pathways with LPCAT4: view

UniProtKB/Swiss-Prot Q643R3-LPCT4_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Interacting Proteins for LPCAT4 Gene

Gene Ontology (GO) - Biological Process for LPCAT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with LPCAT4: view

No data available for SIGNOR curated interactions for LPCAT4 Gene

Drugs & Compounds for LPCAT4 Gene

(1) Drugs for LPCAT4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(41) Additional Compounds for LPCAT4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with LPCAT4: view

Transcripts for LPCAT4 Gene

Unigene Clusters for LPCAT4 Gene

Lysophosphatidylcholine acyltransferase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPCAT4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7: -

Relevant External Links for LPCAT4 Gene

GeneLoc Exon Structure for
LPCAT4
ECgene alternative splicing isoforms for
LPCAT4

Expression for LPCAT4 Gene

mRNA expression in normal human tissues for LPCAT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LPCAT4 Gene

This gene is overexpressed in Breast (56.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LPCAT4 Gene



SOURCE GeneReport for Unigene cluster for LPCAT4 Gene Hs.352614

mRNA Expression by UniProt/SwissProt for LPCAT4 Gene

Q643R3-LPCT4_HUMAN
Tissue specificity: Widely expressed with predominant level in brain.
genes like me logo Genes that share expression patterns with LPCAT4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for LPCAT4 Gene

Orthologs for LPCAT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LPCAT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPCAT4 35
  • 99.36 (n)
  • 99.62 (a)
LPCAT4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPCAT4 36
  • 92 (a)
OneToOne
LPCAT4 35
  • 91.04 (n)
  • 93.81 (a)
dog
(Canis familiaris)
Mammalia LPCAT4 35
  • 88.61 (n)
  • 91.67 (a)
LPCAT4 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpcat4 16
Lpcat4 36
  • 93 (a)
OneToOne
Lpcat4 35
  • 88.8 (n)
  • 93.32 (a)
oppossum
(Monodelphis domestica)
Mammalia LPCAT4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPCAT4 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpcat4 35
  • 88.44 (n)
  • 93.1 (a)
lizard
(Anolis carolinensis)
Reptilia LPCAT4 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpcat4 35
  • 57.29 (n)
  • 53.27 (a)
Str.20517 35
zebrafish
(Danio rerio)
Actinopterygii lpcat4 35
  • 51.52 (n)
  • 43.6 (a)
lpcat4 36
  • 40 (a)
OneToMany
LPCAT4 (2 of 2) 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32699 36
  • 29 (a)
OneToMany
Species with no ortholog for LPCAT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPCAT4 Gene

ENSEMBL:
Gene Tree for LPCAT4 (if available)
TreeFam:
Gene Tree for LPCAT4 (if available)

Paralogs for LPCAT4 Gene

Paralogs for LPCAT4 Gene

(3) SIMAP similar genes for LPCAT4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LPCAT4: view

Variants for LPCAT4 Gene

Sequence variations from dbSNP and Humsavar for LPCAT4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs347897 -- 34,368,215(+) CGCCA(C/T)TGGCT upstream-variant-2KB
rs1390425 -- 34,366,218(+) TCTTA(G/T)AGTAC intron-variant
rs2270612 -- 34,367,348(+) CAGCC(G/T)CTCGG upstream-variant-2KB
rs2270613 -- 34,367,349(+) AGCCG(C/G)TCGGG upstream-variant-2KB
rs2279686 -- 34,362,517(+) CGCCC(C/T)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPCAT4 Gene

Variant ID Type Subtype PubMed ID
esv33337 CNV Gain+Loss 17666407
dgv730e1 CNV Complex 17122850
dgv731e1 CNV Complex 17122850
nsv428303 CNV Gain 18775914
nsv471682 CNV Gain+Loss 15918152
nsv469547 CNV Loss 16826518
dgv732e1 CNV Complex 17122850
nsv482995 CNV Loss 15286789
nsv509567 CNV Insertion 20534489
nsv1485 CNV Loss 18451855
nsv517751 CNV Gain+Loss 19592680
nsv471236 CNV Loss 18288195
nsv820052 CNV Loss 19587683

Variation tolerance for LPCAT4 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPCAT4 Gene

HapMap Linkage Disequilibrium report
LPCAT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPCAT4 Gene

Disorders for LPCAT4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LPCAT4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endometriosis of ovary
  • ovarian endometriosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LPCAT4

Genetic Association Database (GAD)
LPCAT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPCAT4
genes like me logo Genes that share disorders with LPCAT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPCAT4 Gene

Publications for LPCAT4 Gene

  1. Molecular identification of a novel mammalian brain isoform of acyl- CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. (PMID: 18458083) Cao J. … Gimeno R.E. (J. Biol. Chem. 2008) 2 3 4 67
  2. Cloning and characterization a novel human 1-acyl-sn-glycerol-3- phosphate acyltransferase gene AGPAT7. (PMID: 16243729) Ye G.-M. … Yu L. (DNA Seq. 2005) 2 3
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for LPCAT4 Gene

Sources for LPCAT4 Gene

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