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Aliases for LPCAT3 Gene

Aliases for LPCAT3 Gene

  • Lysophosphatidylcholine Acyltransferase 3 2 3 4 5
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 5 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 5 2 3
  • Membrane Bound O-Acyltransferase Domain Containing 5 2 3
  • 1-Acylglycerophosphocholine O-Acyltransferase 3 4
  • O-Acyltransferase Domain-Containing Protein 5 3 4
  • 1-Acylglycerophosphoserine O-Acyltransferase 3 4
  • Lysophosphatidylserine Acyltransferase 3 4
  • Lyso-PC Acyltransferase 3 3 4
  • Lyso-PS Acyltransferase 3 4
  • LPLAT 5 3 4
  • MBOAT5 3 4
  • Lpcat 3 4
  • OACT5 3 4
  • LPSAT 3 4
  • Lysophosphatidylcholine Acyltransferase 4
  • Putative Protein Similar To Nessy 3
  • Lyso-PC Acyltransferase 4
  • EC 2.3.1.23 4
  • EC 2.3.1.n6 4
  • EC 2.3.1.- 4
  • Nessy 3
  • C3F 3

External Ids for LPCAT3 Gene

Previous HGNC Symbols for LPCAT3 Gene

  • OACT5
  • MBOAT5

Previous GeneCards Identifiers for LPCAT3 Gene

  • GC12M006958
  • GC12M007085

Summaries for LPCAT3 Gene

GeneCards Summary for LPCAT3 Gene

LPCAT3 (Lysophosphatidylcholine Acyltransferase 3) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Acyl chain remodelling of PC. GO annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerophosphocholine O-acyltransferase activity. An important paralog of this gene is MBOAT7.

UniProtKB/Swiss-Prot for LPCAT3 Gene

  • Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Gene Wiki entry for LPCAT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPCAT3 Gene

Genomics for LPCAT3 Gene

Regulatory Elements for LPCAT3 Gene

Enhancers for LPCAT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LPCAT3 on UCSC Golden Path with GeneCards custom track

Promoters for LPCAT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LPCAT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPCAT3 Gene

Chromosome:
12
Start:
6,976,185 bp from pter
End:
7,018,538 bp from pter
Size:
42,354 bases
Orientation:
Minus strand

Genomic View for LPCAT3 Gene

Genes around LPCAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPCAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPCAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPCAT3 Gene

Proteins for LPCAT3 Gene

  • Protein details for LPCAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1A2-MBOA5_HUMAN
    Recommended name:
    Lysophospholipid acyltransferase 5
    Protein Accession:
    Q6P1A2
    Secondary Accessions:
    • B2RDH0
    • B7Z3N3
    • Q7KZS1
    • Q92980
    • Q9BW40

    Protein attributes for LPCAT3 Gene

    Size:
    487 amino acids
    Molecular mass:
    56035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB51326.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC51640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37917.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LPCAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPCAT3 Gene

Proteomics data for LPCAT3 Gene at MOPED

Post-translational modifications for LPCAT3 Gene

  • Ubiquitination at Lys 175
  • Modification sites at PhosphoSitePlus

Other Protein References for LPCAT3 Gene

No data available for DME Specific Peptides for LPCAT3 Gene

Domains & Families for LPCAT3 Gene

Gene Families for LPCAT3 Gene

Protein Domains for LPCAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P1A2

UniProtKB/Swiss-Prot:

MBOA5_HUMAN :
  • The di-lysine motif confers endoplasmic reticulum localization.
  • Belongs to the membrane-bound acyltransferase family.
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization.
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with LPCAT3: view

Function for LPCAT3 Gene

Molecular function for LPCAT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=41.29 uM for palmitoyl-CoA {ECO:0000269 PubMed:18195019}; KM=36.65 uM for stearoyl-CoA {ECO:0000269 PubMed:18195019}; KM=72.68 uM for oleoyl-CoA {ECO:0000269 PubMed:18195019}; KM=201.4 uM for linoleoyl-CoA {ECO:0000269 PubMed:18195019}; KM=71.56 uM for arachidonoyl-CoA {ECO:0000269 PubMed:18195019}; KM=72.19 uM for 1-palmitoyl-lysophosphatidylcholine {ECO:0000269 PubMed:18195019}; Vmax=1782 nmol/min/mg enzyme with palmitoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=996 nmol/min/mg enzyme with stearoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=4698 nmol/min/mg enzyme with oleoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=18148 nmol/min/mg enzyme with linoleoyl-CoA and 1- palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=6247 nmol/min/mg enzyme with arachidonoyl-CoA and 1- palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylserine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is inhibited by thimerosal.
UniProtKB/Swiss-Prot Function:
Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Enzyme Numbers (IUBMB) for LPCAT3 Gene

Gene Ontology (GO) - Molecular Function for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with LPCAT3: view

Phenotypes for LPCAT3 Gene

genes like me logo Genes that share phenotypes with LPCAT3: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LPCAT3 Gene

Localization for LPCAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPCAT3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPCAT3 Gene COMPARTMENTS Subcellular localization image for LPCAT3 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LPCAT3: view

Pathways & Interactions for LPCAT3 Gene

genes like me logo Genes that share pathways with LPCAT3: view

Pathways by source for LPCAT3 Gene

UniProtKB/Swiss-Prot Q6P1A2-MBOA5_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Interacting Proteins for LPCAT3 Gene

Gene Ontology (GO) - Biological Process for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
GO:0036152 phosphatidylethanolamine acyl-chain remodeling TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046474 glycerophospholipid biosynthetic process TAS --
GO:0097006 regulation of plasma lipoprotein particle levels IEA --
genes like me logo Genes that share ontologies with LPCAT3: view

No data available for SIGNOR curated interactions for LPCAT3 Gene

Drugs & Compounds for LPCAT3 Gene

(2) Drugs for LPCAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(71) Additional Compounds for LPCAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with LPCAT3: view

Transcripts for LPCAT3 Gene

Unigene Clusters for LPCAT3 Gene

Lysophosphatidylcholine acyltransferase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPCAT3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 14a · 14b ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for LPCAT3 Gene

GeneLoc Exon Structure for
LPCAT3
ECgene alternative splicing isoforms for
LPCAT3

Expression for LPCAT3 Gene

mRNA expression in normal human tissues for LPCAT3 Gene

Protein differential expression in normal tissues from HIPED for LPCAT3 Gene

This gene is overexpressed in Nasal epithelium (34.6) and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LPCAT3 Gene



SOURCE GeneReport for Unigene cluster for LPCAT3 Gene Hs.655248

mRNA Expression by UniProt/SwissProt for LPCAT3 Gene

Q6P1A2-MBOA5_HUMAN
Tissue specificity: Highly expressed in liver, pancreas and adipose tissue. Very low expression in skeletal muscle and heart. Detected in neutrophils.
genes like me logo Genes that share expression patterns with LPCAT3: view

Protein tissue co-expression partners for LPCAT3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LPCAT3 Gene

Orthologs for LPCAT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LPCAT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPCAT3 35
  • 87.29 (n)
  • 87.63 (a)
LPCAT3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPCAT3 35
  • 91.84 (n)
  • 92.59 (a)
LPCAT3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpcat3 35
  • 87.75 (n)
  • 87.27 (a)
Lpcat3 16
Lpcat3 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPCAT3 35
  • 99.79 (n)
  • 99.79 (a)
LPCAT3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpcat3 35
  • 87.95 (n)
  • 87.06 (a)
oppossum
(Monodelphis domestica)
Mammalia LPCAT3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPCAT3 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPCAT3 35
  • 72.15 (n)
  • 72.08 (a)
LPCAT3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPCAT3 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpcat3 35
  • 68.2 (n)
  • 70.09 (a)
zebrafish
(Danio rerio)
Actinopterygii lpcat3 35
  • 63.11 (n)
  • 64.27 (a)
lpcat3 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012258 35
  • 49.43 (n)
  • 38.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta nes 35
  • 50.23 (n)
  • 38.43 (a)
nes 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mboa-6 35
  • 45.85 (n)
  • 34.28 (a)
mboa-6 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9665 36
  • 38 (a)
OneToOne
Species with no ortholog for LPCAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LPCAT3 Gene

ENSEMBL:
Gene Tree for LPCAT3 (if available)
TreeFam:
Gene Tree for LPCAT3 (if available)

Paralogs for LPCAT3 Gene

Paralogs for LPCAT3 Gene

Pseudogenes.org Pseudogenes for LPCAT3 Gene

genes like me logo Genes that share paralogs with LPCAT3: view

Variants for LPCAT3 Gene

Sequence variations from dbSNP and Humsavar for LPCAT3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_050027 -
VAR_050028 -
rs7306673 -- 7,013,092(+) ATTCC(A/G)GTCAG intron-variant
rs16928105 -- 7,006,891(+) GAAAC(C/T)TCGAG intron-variant
rs16933015 -- 6,979,967(+) TTGAT(G/T)CTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPCAT3 Gene

Variant ID Type Subtype PubMed ID
nsv509453 CNV Insertion 20534489
nsv513352 CNV Insertion 21212237
esv1188372 CNV Insertion 17803354
esv2579054 CNV Insertion 19546169
nsv513353 CNV Insertion 21212237

Variation tolerance for LPCAT3 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.28; 90.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPCAT3 Gene

HapMap Linkage Disequilibrium report
LPCAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPCAT3 Gene

Disorders for LPCAT3 Gene

Relevant External Links for LPCAT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPCAT3

No disorders were found for LPCAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPCAT3 Gene

Publications for LPCAT3 Gene

  1. Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. (PMID: 18195019) Zhao Y. … Cao G. (J. Biol. Chem. 2008) 2 3 4 67
  2. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari M.A. … Gibbs R.A. (Genome Res. 1997) 2 3
  3. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. (PMID: 8723724) Ansari-Lari M.A. … Gibbs R.A. (Genome Res. 1996) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for LPCAT3 Gene

Sources for LPCAT3 Gene

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