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Aliases for LPCAT3 Gene

Aliases for LPCAT3 Gene

  • Lysophosphatidylcholine Acyltransferase 3 2 3 4 5
  • Membrane-Bound O-Acyltransferase Domain-Containing Protein 5 3 4
  • O-Acyltransferase (Membrane Bound) Domain Containing 5 2 3
  • Membrane Bound O-Acyltransferase Domain Containing 5 2 3
  • 1-Acylglycerophosphocholine O-Acyltransferase 3 4
  • O-Acyltransferase Domain-Containing Protein 5 3 4
  • 1-Acylglycerophosphoserine O-Acyltransferase 3 4
  • Lysophosphatidylserine Acyltransferase 3 4
  • Lyso-PC Acyltransferase 3 3 4
  • Lyso-PS Acyltransferase 3 4
  • LPLAT 5 3 4
  • MBOAT5 3 4
  • Lpcat 3 4
  • OACT5 3 4
  • LPSAT 3 4
  • Lysophosphatidylcholine Acyltransferase 4
  • Lysophospholipid Acyltransferase 5 3
  • Putative Protein Similar To Nessy 3
  • Lyso-PC Acyltransferase 4
  • EC 2.3.1.23 4
  • EC 2.3.1.n6 4
  • EC 2.3.1.- 4
  • Nessy 3
  • C3F 3

External Ids for LPCAT3 Gene

Previous HGNC Symbols for LPCAT3 Gene

  • OACT5
  • MBOAT5

Previous GeneCards Identifiers for LPCAT3 Gene

  • GC12M006958
  • GC12M007085

Summaries for LPCAT3 Gene

GeneCards Summary for LPCAT3 Gene

LPCAT3 (Lysophosphatidylcholine Acyltransferase 3) is a Protein Coding gene. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include transferase activity, transferring acyl groups and 1-acylglycerophosphocholine O-acyltransferase activity. An important paralog of this gene is MBOAT1.

UniProtKB/Swiss-Prot for LPCAT3 Gene

  • Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Gene Wiki entry for LPCAT3 Gene

Additional gene information for LPCAT3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPCAT3 Gene

Genomics for LPCAT3 Gene

Regulatory Elements for LPCAT3 Gene

Enhancers for LPCAT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006940 1.9 FANTOM5 ENCODE dbSUPER 15.1 +64.9 64880 25 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF384 CHD4 ENSG00000219410 ENSG00000247853 SPSB2 NCAPD2 SCARNA12 ING4 ENSG00000256967 EMG1
GH12H006344 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +671.9 671929 3 PKNOX1 ATF1 ARNT SIN3A BRCA1 TCF12 GATA2 ATF7 FOS DEK CHD4 ENSG00000219410 ZNF384 ENSG00000247853 PHB2 LTBR SCNN1A VAMP1 C1RL-AS1 ENSG00000256967
GH12H007059 1.2 Ensembl ENCODE 11.4 -42.2 -42230 2 ELF3 FOXA2 ARID4B SIN3A RAD21 YY1 ZNF143 THAP11 MXD4 CEBPB C1R C1RL C1RL-AS1 LPCAT3 PHB2 EMG1 SCARNA12 RNU6-485P GC12P007479 PIR53702
GH12H006967 1.1 ENCODE 6.3 +48.6 48621 5 FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF384 EMG1 CHD4 ENSG00000247853 NOP2 LOC100419825 LOC100420983 LOC100131676 NANOGNB RPS20P29
GH12H007016 1.4 ENCODE dbSUPER 0.7 +0.3 326 2 HDGF SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS SP3 NFYC CLSTN3 LPCAT3 PIR59434 GC12M007017
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LPCAT3 on UCSC Golden Path with GeneCards custom track

Promoters for LPCAT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048383 138 2001 HDGF SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 NFYC

Genomic Location for LPCAT3 Gene

Chromosome:
12
Start:
6,976,185 bp from pter
End:
7,018,538 bp from pter
Size:
42,354 bases
Orientation:
Minus strand

Genomic View for LPCAT3 Gene

Genes around LPCAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPCAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPCAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPCAT3 Gene

Proteins for LPCAT3 Gene

  • Protein details for LPCAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1A2-MBOA5_HUMAN
    Recommended name:
    Lysophospholipid acyltransferase 5
    Protein Accession:
    Q6P1A2
    Secondary Accessions:
    • B2RDH0
    • B7Z3N3
    • Q7KZS1
    • Q92980
    • Q9BW40

    Protein attributes for LPCAT3 Gene

    Size:
    487 amino acids
    Molecular mass:
    56035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB51326.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC51640.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37917.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LPCAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPCAT3 Gene

Post-translational modifications for LPCAT3 Gene

  • Ubiquitination at posLast=175175
  • Modification sites at PhosphoSitePlus

Other Protein References for LPCAT3 Gene

No data available for DME Specific Peptides for LPCAT3 Gene

Domains & Families for LPCAT3 Gene

Gene Families for LPCAT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for LPCAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P1A2

UniProtKB/Swiss-Prot:

MBOA5_HUMAN :
  • The di-lysine motif confers endoplasmic reticulum localization.
  • Belongs to the membrane-bound acyltransferase family.
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization.
Family:
  • Belongs to the membrane-bound acyltransferase family.
genes like me logo Genes that share domains with LPCAT3: view

Function for LPCAT3 Gene

Molecular function for LPCAT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=41.29 uM for palmitoyl-CoA {ECO:0000269 PubMed:18195019}; KM=36.65 uM for stearoyl-CoA {ECO:0000269 PubMed:18195019}; KM=72.68 uM for oleoyl-CoA {ECO:0000269 PubMed:18195019}; KM=201.4 uM for linoleoyl-CoA {ECO:0000269 PubMed:18195019}; KM=71.56 uM for arachidonoyl-CoA {ECO:0000269 PubMed:18195019}; KM=72.19 uM for 1-palmitoyl-lysophosphatidylcholine {ECO:0000269 PubMed:18195019}; Vmax=1782 nmol/min/mg enzyme with palmitoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=996 nmol/min/mg enzyme with stearoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=4698 nmol/min/mg enzyme with oleoyl-CoA and 1-palmitoyl- lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=18148 nmol/min/mg enzyme with linoleoyl-CoA and 1- palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019}; Vmax=6247 nmol/min/mg enzyme with arachidonoyl-CoA and 1- palmitoyl-lysophosphatidylcholine as substrates {ECO:0000269 PubMed:18195019};
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylserine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is inhibited by thimerosal.
UniProtKB/Swiss-Prot Function:
Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.

Enzyme Numbers (IUBMB) for LPCAT3 Gene

Phenotypes From GWAS Catalog for LPCAT3 Gene

Gene Ontology (GO) - Molecular Function for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity TAS --
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity IMP 22511767
genes like me logo Genes that share ontologies with LPCAT3: view
genes like me logo Genes that share phenotypes with LPCAT3: view

Animal Models for LPCAT3 Gene

MGI Knock Outs for LPCAT3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LPCAT3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPCAT3 Gene

Localization for LPCAT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPCAT3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPCAT3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPCAT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LPCAT3 Gene

Pathways & Interactions for LPCAT3 Gene

genes like me logo Genes that share pathways with LPCAT3: view

Pathways by source for LPCAT3 Gene

UniProtKB/Swiss-Prot Q6P1A2-MBOA5_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Gene Ontology (GO) - Biological Process for LPCAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0036150 phosphatidylserine acyl-chain remodeling TAS --
GO:0036151 phosphatidylcholine acyl-chain remodeling TAS --
genes like me logo Genes that share ontologies with LPCAT3: view

No data available for SIGNOR curated interactions for LPCAT3 Gene

Drugs & Compounds for LPCAT3 Gene

(3) Drugs for LPCAT3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0
Coenzyme A Nutra 0

(70) Additional Compounds for LPCAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with LPCAT3: view

Transcripts for LPCAT3 Gene

Unigene Clusters for LPCAT3 Gene

Lysophosphatidylcholine acyltransferase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LPCAT3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LPCAT3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 14a · 14b ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for LPCAT3 Gene

GeneLoc Exon Structure for
LPCAT3
ECgene alternative splicing isoforms for
LPCAT3

Expression for LPCAT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPCAT3 Gene

Protein differential expression in normal tissues from HIPED for LPCAT3 Gene

This gene is overexpressed in Nasal epithelium (34.6) and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LPCAT3 Gene



Protein tissue co-expression partners for LPCAT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LPCAT3 Gene:

LPCAT3

SOURCE GeneReport for Unigene cluster for LPCAT3 Gene:

Hs.655248

mRNA Expression by UniProt/SwissProt for LPCAT3 Gene:

Q6P1A2-MBOA5_HUMAN
Tissue specificity: Highly expressed in liver, pancreas and adipose tissue. Very low expression in skeletal muscle and heart. Detected in neutrophils.

Evidence on tissue expression from TISSUES for LPCAT3 Gene

  • Blood(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with LPCAT3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPCAT3 Gene

Orthologs for LPCAT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LPCAT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPCAT3 33 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia LPCAT3 33 34
  • 91.84 (n)
rat
(Rattus norvegicus)
Mammalia Lpcat3 33
  • 87.95 (n)
mouse
(Mus musculus)
Mammalia Lpcat3 33 16 34
  • 87.75 (n)
cow
(Bos Taurus)
Mammalia LPCAT3 33 34
  • 87.29 (n)
oppossum
(Monodelphis domestica)
Mammalia LPCAT3 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPCAT3 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPCAT3 33 34
  • 72.15 (n)
lizard
(Anolis carolinensis)
Reptilia LPCAT3 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpcat3 33
  • 68.2 (n)
zebrafish
(Danio rerio)
Actinopterygii lpcat3 33 34
  • 63.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta nes 33 34
  • 50.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012258 33
  • 49.43 (n)
worm
(Caenorhabditis elegans)
Secernentea mboa-6 33 34
  • 45.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALE1 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9665 34
  • 38 (a)
OneToOne
Species where no ortholog for LPCAT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LPCAT3 Gene

ENSEMBL:
Gene Tree for LPCAT3 (if available)
TreeFam:
Gene Tree for LPCAT3 (if available)

Paralogs for LPCAT3 Gene

Paralogs for LPCAT3 Gene

Pseudogenes.org Pseudogenes for LPCAT3 Gene

genes like me logo Genes that share paralogs with LPCAT3: view

Variants for LPCAT3 Gene

Sequence variations from dbSNP and Humsavar for LPCAT3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000224637 -- 6,982,231(+) ATGGG(A/G/T)TTTCA intron-variant
rs1000241626 -- 6,989,889(+) TAAAT(A/T)TGGCT intron-variant
rs1000343388 -- 7,015,093(+) CGATG(C/G)ATCTT intron-variant
rs1000388112 -- 6,996,876(+) ATGTA(A/G)TAAAG intron-variant
rs1000501528 -- 6,988,333(+) CCTGG(A/G)AGCAA intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for LPCAT3 Gene

Variant ID Type Subtype PubMed ID
esv1188372 CNV insertion 17803354
esv2579054 CNV insertion 19546169
esv3628412 CNV loss 21293372
nsv1035811 CNV gain 25217958
nsv1039509 CNV gain 25217958
nsv1047373 CNV gain 25217958
nsv480390 CNV novel sequence insertion 20440878
nsv509453 CNV insertion 20534489
nsv513352 CNV insertion 21212237
nsv513353 CNV insertion 21212237

Variation tolerance for LPCAT3 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.28; 90.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPCAT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPCAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPCAT3 Gene

Disorders for LPCAT3 Gene

Relevant External Links for LPCAT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPCAT3

No disorders were found for LPCAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPCAT3 Gene

Publications for LPCAT3 Gene

  1. Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. (PMID: 18195019) Zhao Y … Cao G (The Journal of biological chemistry 2008) 2 3 4 60
  2. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PMID: 9074930) Ansari-Lari MA … Gibbs RA (Genome research 1997) 2 3 4 60
  3. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. (PMID: 18772128) Gijón MA … Voelker DR (The Journal of biological chemistry 2008) 3 4 60
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for LPCAT3 Gene

Sources for LPCAT3 Gene

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