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Aliases for LPCAT2 Gene

Aliases for LPCAT2 Gene

  • Lysophosphatidylcholine Acyltransferase 2 2 3 5
  • Acetyl-CoA:Lyso-Platelet-Activating Factor Acetyltransferase 3 4
  • 1-Alkylglycerophosphocholine O-Acetyltransferase 3 4
  • 1-Acylglycerol-3-Phosphate O-Acyltransferase 11 3 4
  • 1-Acylglycerophosphocholine O-Acyltransferase 3 4
  • Lysophosphatidic Acid Acyltransferase Alpha 3 4
  • Acetyl-CoA:Lyso-PAF Acetyltransferase 3 4
  • Lyso-PAF Acetyltransferase 3 4
  • LysoPC Acyltransferase 2 3 4
  • 1-AGP Acyltransferase 11 3 4
  • Acyltransferase Like 1 2 3
  • Acyltransferase-Like 1 3 4
  • LPC Acyltransferase 2 3 4
  • LPAAT-Alpha 3 4
  • EC 2.3.1.23 4 63
  • 1-AGPAT 11 3 4
  • LysoPAFAT 3 4
  • AGPAT11 3 4
  • LPCAT-2 3 4
  • AYTL1 3 4
  • Lyso-Platelet-Activating Factor (PAF) Acetyltransferase 3
  • Acyl-CoA:Lysophosphatidylcholine Acyltransferase 2 3
  • EC 2.3.1.51 4
  • EC 2.3.1.67 4
  • EC 2.3.1 63

External Ids for LPCAT2 Gene

Previous HGNC Symbols for LPCAT2 Gene

  • AYTL1

Previous GeneCards Identifiers for LPCAT2 Gene

  • GC16P054102
  • GC16P041430

Summaries for LPCAT2 Gene

Entrez Gene Summary for LPCAT2 Gene

  • This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]

GeneCards Summary for LPCAT2 Gene

LPCAT2 (Lysophosphatidylcholine Acyltransferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include calcium ion binding and 1-acylglycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is LPCAT1.

UniProtKB/Swiss-Prot for LPCAT2 Gene

  • Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPCAT2 Gene

Genomics for LPCAT2 Gene

Regulatory Elements for LPCAT2 Gene

Enhancers for LPCAT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LPCAT2 on UCSC Golden Path with GeneCards custom track

Promoters for LPCAT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LPCAT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPCAT2 Gene

Chromosome:
16
Start:
55,508,998 bp from pter
End:
55,586,670 bp from pter
Size:
77,673 bases
Orientation:
Plus strand

Genomic View for LPCAT2 Gene

Genes around LPCAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPCAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPCAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPCAT2 Gene

Proteins for LPCAT2 Gene

  • Protein details for LPCAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5N7-PCAT2_HUMAN
    Recommended name:
    Lysophosphatidylcholine acyltransferase 2
    Protein Accession:
    Q7L5N7
    Secondary Accessions:
    • A3KBM1
    • Q6MZJ6
    • Q9NX23

    Protein attributes for LPCAT2 Gene

    Size:
    544 amino acids
    Molecular mass:
    60208 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91199.1; Type=Frameshift; Positions=44; Evidence={ECO:0000305}; Sequence=CAE46034.1; Type=Frameshift; Positions=295; Evidence={ECO:0000305};

    Alternative splice isoforms for LPCAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPCAT2 Gene

Proteomics data for LPCAT2 Gene at MOPED

Selected DME Specific Peptides for LPCAT2 Gene

Post-translational modifications for LPCAT2 Gene

  • Ubiquitination at Lys 386 and Lys 389
  • Modification sites at PhosphoSitePlus

Other Protein References for LPCAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for LPCAT2 Gene

Suggested Antigen Peptide Sequences for LPCAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L5N7

UniProtKB/Swiss-Prot:

PCAT2_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LPCAT2: view

Function for LPCAT2 Gene

Molecular function for LPCAT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Acetyltransferase activity is increased following acute inflammatory stimulation by lipopolysaccharide (LPS). Acyltransferase activity is unchanged (By similarity).
UniProtKB/Swiss-Prot Function:
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.

Enzyme Numbers (IUBMB) for LPCAT2 Gene

Gene Ontology (GO) - Molecular Function for LPCAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity IEA,TAS --
GO:0005509 calcium ion binding IEA --
GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with LPCAT2: view
genes like me logo Genes that share phenotypes with LPCAT2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LPCAT2 Gene

Localization for LPCAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPCAT2 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Lipid droplet.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPCAT2 Gene COMPARTMENTS Subcellular localization image for LPCAT2 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 4
cytosol 2
mitochondrion 2
plasma membrane 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for LPCAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005795 Golgi stack IEA,ISS --
GO:0005811 lipid particle IDA 21498505
genes like me logo Genes that share ontologies with LPCAT2: view

Pathways & Interactions for LPCAT2 Gene

genes like me logo Genes that share pathways with LPCAT2: view

UniProtKB/Swiss-Prot Q7L5N7-PCAT2_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Interacting Proteins for LPCAT2 Gene

Gene Ontology (GO) - Biological Process for LPCAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0061024 membrane organization IEA,ISS --
genes like me logo Genes that share ontologies with LPCAT2: view

No data available for SIGNOR curated interactions for LPCAT2 Gene

Drugs & Compounds for LPCAT2 Gene

(1) Drugs for LPCAT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(51) Additional Compounds for LPCAT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
genes like me logo Genes that share compounds with LPCAT2: view

Transcripts for LPCAT2 Gene

Unigene Clusters for LPCAT2 Gene

Lysophosphatidylcholine acyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPCAT2 Gene

No ASD Table

Relevant External Links for LPCAT2 Gene

GeneLoc Exon Structure for
LPCAT2
ECgene alternative splicing isoforms for
LPCAT2

Expression for LPCAT2 Gene

mRNA expression in normal human tissues for LPCAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPCAT2 Gene

This gene is overexpressed in Whole Blood (x7.5) and Thyroid (x4.6).

Protein differential expression in normal tissues from HIPED for LPCAT2 Gene

This gene is overexpressed in Breast (43.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LPCAT2 Gene



SOURCE GeneReport for Unigene cluster for LPCAT2 Gene Hs.460857

genes like me logo Genes that share expression patterns with LPCAT2: view

Protein tissue co-expression partners for LPCAT2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LPCAT2 Gene

Orthologs for LPCAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LPCAT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPCAT2 35
  • 89.22 (n)
  • 88.97 (a)
LPCAT2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPCAT2 35
  • 90.2 (n)
  • 90.44 (a)
LPCAT2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpcat2 35
  • 84.62 (n)
  • 88.42 (a)
Lpcat2 16
Lpcat2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPCAT2 35
  • 99.2 (n)
  • 98.71 (a)
LPCAT2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpcat2 35
  • 83.39 (n)
  • 89.15 (a)
oppossum
(Monodelphis domestica)
Mammalia LPCAT2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPCAT2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPCAT2 35
  • 69.58 (n)
  • 66.6 (a)
LPCAT2 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPCAT2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpcat2 35
  • 65.64 (n)
  • 65.77 (a)
zebrafish
(Danio rerio)
Actinopterygii lpcat2 35
  • 62.27 (n)
  • 61.43 (a)
lpcat2 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000596 35
  • 47.09 (n)
  • 39.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32699 36
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G45670 35
  • 44.78 (n)
  • 30.56 (a)
rice
(Oryza sativa)
Liliopsida Os06g0712300 35
  • 44.28 (n)
  • 30.33 (a)
Species with no ortholog for LPCAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPCAT2 Gene

ENSEMBL:
Gene Tree for LPCAT2 (if available)
TreeFam:
Gene Tree for LPCAT2 (if available)

Paralogs for LPCAT2 Gene

Paralogs for LPCAT2 Gene

(3) SIMAP similar genes for LPCAT2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for LPCAT2 Gene

genes like me logo Genes that share paralogs with LPCAT2: view

Variants for LPCAT2 Gene

Sequence variations from dbSNP and Humsavar for LPCAT2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs837550 - 55,528,554(+) TCTAT(A/G)GTATC upstream-variant-2KB, reference, missense
rs3996858 -- 55,561,370(+) TTTTT(-/T/TT/TTT)GCAGA intron-variant
rs4238780 -- 55,539,409(+) GCCGC(A/G)TCGAC intron-variant
rs168822 -- 55,569,556(+) TGTTC(C/T)TCACT intron-variant
rs183154 -- 55,575,346(+) CATTT(A/G)CTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPCAT2 Gene

Variant ID Type Subtype PubMed ID
nsv521337 CNV Loss 19592680

Variation tolerance for LPCAT2 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LPCAT2 Gene

Disorders for LPCAT2 Gene

Relevant External Links for LPCAT2

Genetic Association Database (GAD)
LPCAT2
Human Genome Epidemiology (HuGE) Navigator
LPCAT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPCAT2

No disorders were found for LPCAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPCAT2 Gene

Publications for LPCAT2 Gene

  1. Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers. (PMID: 20363836) Agarwal A.K. … Garg A. (J. Lipid Res. 2010) 2 3 4 67
  2. A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:lyso-PAF acetyltransferase. (PMID: 17182612) Shindou H. … Shimizu T. (J. Biol. Chem. 2007) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes. (PMID: 25411967) Williams K.A. … Crawford N.P. (PLoS Genet. 2014) 3

Products for LPCAT2 Gene

Sources for LPCAT2 Gene

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