Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LPCAT1 Gene

Aliases for LPCAT1 Gene

  • Lysophosphatidylcholine Acyltransferase 1 2 3
  • Acetyl-CoA:Lyso-Platelet-Activating Factor Acetyltransferase 3 4
  • 1-Alkylglycerophosphocholine O-Acetyltransferase 3 4
  • 1-Acylglycerophosphocholine O-Acyltransferase 3 4
  • Phosphonoformate Immuno-Associated Protein 3 3 4
  • Acetyl-CoA:Lyso-PAF Acetyltransferase 3 4
  • Lyso-PAF Acetyltransferase 3 4
  • LysoPC Acyltransferase 1 3 4
  • Acyltransferase Like 2 2 3
  • Acyltransferase-Like 2 3 4
  • LPC Acyltransferase 1 3 4
  • LysoPAFAT 3 4
  • LPCAT-1 3 4
  • PFAAP3 3 4
  • AYTL2 3 4
  • Acyl-CoA:Lysophosphatidylcholine Acyltransferase 1 3
  • Regulated By Phosphonoformate 3
  • EC 2.3.1.23 4
  • EC 2.3.1.67 4
  • LPCAT 3

External Ids for LPCAT1 Gene

Previous HGNC Symbols for LPCAT1 Gene

  • AYTL2

Previous GeneCards Identifiers for LPCAT1 Gene

  • GC05M001516

Summaries for LPCAT1 Gene

Entrez Gene Summary for LPCAT1 Gene

  • Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006 [PubMed 16704971]).[supplied by OMIM, May 2008]

GeneCards Summary for LPCAT1 Gene

LPCAT1 (Lysophosphatidylcholine Acyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include calcium ion binding and 1-acylglycerophosphocholine O-acyltransferase activity. An important paralog of this gene is LPCAT4.

UniProtKB/Swiss-Prot for LPCAT1 Gene

  • Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPCAT1 Gene

Genomics for LPCAT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LPCAT1 Gene

Chromosome:
5
Start:
1,456,480 bp from pter
End:
1,525,730 bp from pter
Size:
69,251 bases
Orientation:
Minus strand

Genomic View for LPCAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPCAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPCAT1 Gene

Proteins for LPCAT1 Gene

  • Protein details for LPCAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NF37-PCAT1_HUMAN
    Recommended name:
    Lysophosphatidylcholine acyltransferase 1
    Protein Accession:
    Q8NF37
    Secondary Accessions:
    • Q1HAQ1
    • Q7Z4G6
    • Q8N3U7
    • Q8WUL8
    • Q9GZW6

    Protein attributes for LPCAT1 Gene

    Size:
    534 amino acids
    Molecular mass:
    59151 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14061.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14065.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for LPCAT1 Gene

Proteomics data for LPCAT1 Gene at MOPED

Post-translational modifications for LPCAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LPCAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for LPCAT1

No data available for DME Specific Peptides for LPCAT1 Gene

Domains & Families for LPCAT1 Gene

Protein Domains for LPCAT1 Gene

Suggested Antigen Peptide Sequences for LPCAT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NF37

UniProtKB/Swiss-Prot:

PCAT1_HUMAN :
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Domain:
  • The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
genes like me logo Genes that share domains with LPCAT1: view

Function for LPCAT1 Gene

Molecular function for LPCAT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Not activated by inflammatory stimulation. Inhibited by Cu(2+) and Fe(2+). Activity is not affected by Co(2+), Mg(2+) or Mn(2+) (By similarity).
UniProtKB/Swiss-Prot Function:
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology.

Enzyme Numbers (IUBMB) for LPCAT1 Gene

Gene Ontology (GO) - Molecular Function for LPCAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0016746 transferase activity, transferring acyl groups --
GO:0047159 1-alkenylglycerophosphocholine O-acyltransferase activity IEA --
GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity ISS --
GO:0047191 1-alkylglycerophosphocholine O-acyltransferase activity IEA --
genes like me logo Genes that share ontologies with LPCAT1: view
genes like me logo Genes that share phenotypes with LPCAT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPCAT1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for LPCAT1 Gene

Localization for LPCAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPCAT1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Lipid droplet. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPCAT1 Gene COMPARTMENTS Subcellular localization image for LPCAT1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 4
cytosol 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LPCAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus ISS --
GO:0005811 lipid particle IDA 21498505
genes like me logo Genes that share ontologies with LPCAT1: view

Pathways & Interactions for LPCAT1 Gene

genes like me logo Genes that share pathways with LPCAT1: view

UniProtKB/Swiss-Prot Q8NF37-PCAT1_HUMAN

  • Pathway: Lipid metabolism; phospholipid metabolism.

Interacting Proteins for LPCAT1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283415%0d%0a9606.ENSP00000215885%0d%0a9606.ENSP00000219345%0d%0a9606.ENSP00000229266%0d%0a9606.ENSP00000240617%0d%0a9606.ENSP00000243501%0d%0a
Selected Interacting proteins: ENSP00000283415 Q8NF37-PCAT1_HUMAN for LPCAT1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for LPCAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0008654 phospholipid biosynthetic process ISS --
GO:0019432 triglyceride biosynthetic process TAS --
genes like me logo Genes that share ontologies with LPCAT1: view

No data available for SIGNOR curated interactions for LPCAT1 Gene

Drugs & Compounds for LPCAT1 Gene

(3) Drugs for LPCAT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
Calcium Nutra 0
Coenzyme A Nutra 0

(81) Additional Compounds for LPCAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with LPCAT1: view

Transcripts for LPCAT1 Gene

Unigene Clusters for LPCAT1 Gene

Lysophosphatidylcholine acyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPCAT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPCAT1 Gene

No ASD Table

Relevant External Links for LPCAT1 Gene

GeneLoc Exon Structure for
LPCAT1
ECgene alternative splicing isoforms for
LPCAT1

Expression for LPCAT1 Gene

mRNA expression in normal human tissues for LPCAT1 Gene

mRNA differential expression in normal tissues according to GTEx for LPCAT1 Gene

This gene is overexpressed in Whole Blood (x6.2) and Lung (x5.2).

Protein differential expression in normal tissues from HIPED for LPCAT1 Gene

This gene is overexpressed in Fetal Brain (9.8), Lung (8.6), NK cells (8.1), Peripheral blood mononuclear cells (7.2), and Bone (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LPCAT1 Gene



SOURCE GeneReport for Unigene cluster for LPCAT1 Gene Hs.368853

genes like me logo Genes that share expression patterns with LPCAT1: view

Protein tissue co-expression partners for LPCAT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LPCAT1 Gene

Orthologs for LPCAT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LPCAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPCAT1 35
  • 82.93 (n)
  • 84.8 (a)
LPCAT1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPCAT1 35
  • 82.13 (n)
  • 83.51 (a)
LPCAT1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpcat1 35
  • 82.83 (n)
  • 88.39 (a)
Lpcat1 16
Lpcat1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPCAT1 35
  • 99.19 (n)
  • 98.87 (a)
LPCAT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpcat1 35
  • 82.96 (n)
  • 88.39 (a)
oppossum
(Monodelphis domestica)
Mammalia LPCAT1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPCAT1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPCAT1 35
  • 69.88 (n)
  • 73.82 (a)
LPCAT1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPCAT1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpcat1 35
  • 69.08 (n)
  • 72.84 (a)
Str.3303 35
zebrafish
(Danio rerio)
Actinopterygii lpcat1 35
  • 66.87 (n)
  • 67.01 (a)
CABZ01078889.1 36
  • 50 (a)
OneToMany
lpcat1 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32699 35
  • 49.75 (n)
  • 39.14 (a)
CG32699 36
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7337 35
Species with no ortholog for LPCAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPCAT1 Gene

ENSEMBL:
Gene Tree for LPCAT1 (if available)
TreeFam:
Gene Tree for LPCAT1 (if available)

Paralogs for LPCAT1 Gene

Paralogs for LPCAT1 Gene

(3) SIMAP similar genes for LPCAT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LPCAT1: view

Variants for LPCAT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for LPCAT1 Gene

Variant ID Type Subtype PubMed ID
nsv880418 CNV Loss 21882294
nsv830187 CNV Loss 17160897
nsv881664 CNV Loss 21882294
nsv880402 CNV Loss 21882294
nsv461910 CNV Loss 19166990
nsv881100 CNV Loss 21882294
nsv881381 CNV Loss 21882294
nsv880939 CNV Loss 21882294
esv2462178 CNV Deletion 19546169
esv3186 CNV Deletion 18987735
dgv5918n71 CNV Loss 21882294
dgv5919n71 CNV Loss 21882294
esv2729492 CNV Deletion 23290073
nsv880392 CNV Loss 21882294
nsv881211 CNV Loss 21882294
esv2729493 CNV Deletion 23290073
esv2387011 CNV Deletion 18987734
esv2729494 CNV Deletion 23290073
nsv329642 CNV Loss 16902084
esv2729495 CNV Deletion 23290073
dgv5920n71 CNV Loss 21882294
nsv880498 CNV Gain 21882294
esv994195 CNV Insertion 20482838
nsv880305 CNV Loss 21882294
esv27188 CNV Loss 19812545

Variation tolerance for LPCAT1 Gene

Residual Variation Intolerance Score: 26.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPCAT1 Gene

HapMap Linkage Disequilibrium report
LPCAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for LPCAT1 Gene

Disorders for LPCAT1 Gene

Relevant External Links for LPCAT1

Genetic Association Database (GAD)
LPCAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPCAT1
genes like me logo Genes that share disorders with LPCAT1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPCAT1 Gene

Publications for LPCAT1 Gene

  1. Cloning and characterization of mouse lung-type acyl- CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production. (PMID: 16704971) Nakanishi H. … Shimizu T. (J. Biol. Chem. 2006) 2 67
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for LPCAT1 Gene

Sources for LPCAT1 Gene

Back to Top

Content