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LPAR6 Gene

protein-coding   GIFtS: 61
GCID: GC13M048963

Lysophosphatidic Acid Receptor 6

(Previous names: purinergic receptor P2Y, G-protein coupled, 5)
(Previous symbol: P2RY5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Lysophosphatidic Acid Receptor 61 2     LPA Receptor 62 3
P2RY51 2 3 5     P2Y Purinoceptor 52 3
P2Y52 3 5     RB Intron Encoded G-Protein Coupled Receptor2 3
Purinergic Receptor P2Y, G-Protein Coupled, 51 2     ARWH12 5
Oleoyl-L-Alpha-Lysophosphatidic Acid Receptor2 3     LAH32 5
Purinergic Receptor 52 3     G-Protein Coupled Purinergic Receptor P2Y52
LPA-62 3     Purinergic Receptor P2Y G Protein-Coupled Protein 52

External Ids:    HGNC: 155201   Entrez Gene: 101612   Ensembl: ENSG000001396797   OMIM: 6092395   UniProtKB: P436573   
ORGUL members:         

Export aliases for LPAR6 gene to outside databases

Previous GC identifers: GC13M047885 GC13M029777


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LPAR6 Gene:
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially
activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma
susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Jun 2009)

GeneCards Summary for LPAR6 Gene:
LPAR6 (lysophosphatidic acid receptor 6) is a protein-coding gene. Diseases associated with LPAR6 include hypotrichosis 8, and woolly hair, autosomal recessive. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: LPAR6_HUMAN, P43657
Function: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor
activation. Important for the maintenance of hair growth and texture

summary for LPAR6 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for LPAR6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Search for regulatory transcription factor binding sites for LPAR6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPAR6 promoter sequence
   Search Chromatin IP Primers for LPAR6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LPAR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14

LPAR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M048963:  view genomic region     (about GC identifiers)

Start:
48,963,707 bp from pter      End:
49,018,840 bp from pter
Size:
55,134 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LPAR6_HUMAN, P43657 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 6  
Size: 344 amino acids; 39392 Da
Developmental stage: Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the
monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the
induction of differentiation along the granulocytic pathway
Miscellaneous: This is a nested gene within intron 17 of the retinoblastoma gene
Sequence caution: Sequence=L11910; Type=Frameshift; Positions=31;
Secondary accessions: A4FTW9 B3KVF2 F2YGU4 O15133 Q3KPF5 Q53FA0 Q5VW44 Q7Z3S0 Q7Z3S6

Explore the universe of human proteins at neXtProt for LPAR6: NX_P43657

Explore proteomics data for LPAR6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus

  • See LPAR6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001155969.1  NP_001155970.1  NP_005758.2  

    ENSEMBL proteins: 
     ENSP00000367691   ENSP00000344353  
    Reactome Protein details: P43657

    LPAR6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for LPAR6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LPAR: GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid

    IUPHAR Guide to PHARMACOLOGY protein family classification: LPA6 receptor
    Lysophospholipid (LPA) receptors

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P43657

    ProtoNet protein and cluster: P43657

    2 Blocks protein domains:
    IPB002188 P2Y5 purinoceptor signature
    IPB002286 P2 purinoceptor signature


    UniProtKB/Swiss-Prot: LPAR6_HUMAN, P43657
    Similarity: Belongs to the G-protein coupled receptor 1 family


    LPAR6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPAR6_HUMAN, P43657
    Function: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor
    activation. Important for the maintenance of hair growth and texture

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    LPAR6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LPAR6:
     Decreased Wnt reporter activit  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Lpar6 (no phenotypes)

    LPAR6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lpar6tm1(KOMP)Vlcg for LPAR6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LPAR6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LPAR6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LPAR6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LPAR6

    miRNA
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    Block miRNA regulation of human, mouse, rat LPAR6 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate LPAR6:
    hsa-miR-155 hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidLPAR6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LPAR6
    Predesigned siRNA for gene silencing in human, mouse, rat LPAR6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): LPAR6 (NM_005767)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPAR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPAR6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LPAR6_HUMAN, P43657: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    LPAR6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LPAR6 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    P2Y receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for LPAR6
        GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs

    2 Reactome Pathways for LPAR6
        P2Y receptors
    G alpha (q) signalling events


    2 Kegg Pathways  (Kegg details for LPAR6):
        Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway


    LPAR6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LPAR6: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LPAR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LPAR6 (ENSP000003443534) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIDEBENSP000003377314STRING: ENSP00000337731
    F2RENSP000003213264STRING: ENSP00000321326
    GPR132ENSP000003288184STRING: ENSP00000328818
    GPR65ENSP000002675494STRING: ENSP00000267549
    GPRC6AENSP000003094934STRING: ENSP00000309493
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    LPAR6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for LPAR6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    Selected HMDB Compounds for LPAR6 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----

    1 IUPHAR Ligand for LPAR6 (LPA6 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    LPA
    AgonistAgonist619386608 18297070



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LPAR6 gene (3 alternative transcripts): 
    NM_001162497.1  NM_001162498.1  NM_005767.5  

    Unigene Cluster for LPAR6:

    Lysophosphatidic acid receptor 6
    Hs.123464  [show with all ESTs]
    Unigene Representative Sequence: NM_005767
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464486 ENST00000481832 ENST00000462781 ENST00000470937 ENST00000378434(uc001vcf.3)
    ENST00000345941(uc001vce.3) ENST00000482024 ENST00000465365(uc001vcc.1)

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate LPAR6:
    hsa-miR-155 hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidLPAR6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): LPAR6 (NM_005767)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPAR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPAR6
    Primer
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    OriGene qPCR primer pairs and template standards for LPAR6
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LPAR6
      QuantiTect SYBR Green Assays in human, mouse, rat LPAR6
      QuantiFast Probe-based Assays in human, mouse, rat LPAR6

    Additional mRNA sequence: 

    AF000546.1 AK122856.1 AK123059.1 AK223389.1 BC040850.1 BC045651.1 BC054346.1 BC070295.1 
    BC106756.2 BX537392.1 BX537438.1 BX537445.1 BX647109.1 HQ995530.1 JF810890.1 

    13 DOTS entries:

    DT.448049  DT.101983571  DT.95145780  DT.95150078  DT.91955771  DT.120781599  DT.120781643  DT.120781901 
    DT.95150079  DT.120781678  DT.120781905  DT.92416256  DT.92456735 

    Selected AceView cDNA sequences (see all 139):

    AA194811 BP381270 AV715405 AI051863 BX537392 CD722586 BC045651 AK122856 
    BE217944 CR597194 BX956559 BX647109 BC070295 BC040850 BQ006077 BQ950264 
    AI148328 NM_005767 AL709780 AI523026 AV711699 BU752648 AA194998 BC054346 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LPAR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTATTT
    LPAR6 Expression
    About this image


    LPAR6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Esophagus (Gastrointestinal Tract)
     
     Placenta (Extraembryonic Tissues)
    LPAR6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LPAR6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123464

    UniProtKB/Swiss-Prot: LPAR6_HUMAN, P43657
    Tissue specificity: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's
    and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at
    protein level). Expressed at low levels in peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LPAR6: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LPAR6
    OriGene qSTAR qPCR primer pairs in human, mouse for LPAR6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LPAR6
    QuantiTect SYBR Green Assays in human, mouse, rat LPAR6
    QuantiFast Probe-based Assays in human, mouse, rat LPAR6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LPAR6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lpar61 , 5 lysophosphatidic acid receptor 61, 5 87.76(n)1
    93.29(a)1
      14 (38.75 cM)5
    671681  NM_175116.41  NP_780325.11 
     732378955 
    chicken
    (Gallus gallus)
    Aves LPAR61 lysophosphatidic acid receptor 6 72.01(n)
    79.23(a)
      396118  NM_205199.2  NP_990530.2 
    lizard
    (Anolis carolinensis)
    Reptilia LPAR66
    lysophosphatidic acid receptor 6
    75(a)
    1 ↔ 1
    1(136895442-136896416)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lpar61 lysophosphatidic acid receptor 6 73.31(n)
    80.06(a)
      100144921  XM_002935103.2  XP_002935149.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lpar6a1 lysophosphatidic acid receptor 6a 62.03(n)
    64.2(a)
      571773  NM_001080055.2  NP_001073524.1 


    ENSEMBL Gene Tree for LPAR6 (if available)
    TreeFam Gene Tree for LPAR6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LPAR6 gene
    OXGR12  P2RY42  GPR172  P2RY12  P2RY62  GPR1742  LPAR52  CYSLTR12  
    GPR1832  LPAR42  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    Selected SIMAP similar genes for LPAR6 using alignment to 1 protein entry:     LPAR6_HUMAN(see all similar genes):
    LPAR4    CYSLTR1    KPG_010    LPAR5    CCR5    AGTR1
    AGTR2    CCR4    F2R    GPR174    P2RY10    CCR2
    CXCR1    CXCR2    GPR17    IL8RB    P2RY2    P2RY4

    LPAR6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LPAR6 (see all 550)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0443284
    Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)4--see VAR_0443282 E K mis40--------
    VAR_0443264
    Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)4--see VAR_0443262 D V mis40--------
    VAR_0443274
    Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)4--see VAR_0443272 I F mis40--------
    rs1397774811,2
    --29927782(+) TAAGTA/GCACCT 3 -- ds50010--------
    rs1159542531,2
    F--29927886(+) GCATAT/GATCAT 3 -- ds50011Minor allele frequency- G:0.03WA 118
    rs41515471,2
    C,H--29927925(+) AATCAA/GAATAG 3 -- ds50016Minor allele frequency- G:0.00NS EA NA 584
    rs41515491,2
    H--29928039(+) AACAAT/CGTTAA 3 -- ds50015Minor allele frequency- C:0.00NS EA 578
    rs1117199731,2
    F--29928072(+) ACTACG/ATTTTT 3 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs41515501,2
    C,F,H--29928365(+) AGGAAC/GAAATC 3 -- ut316Minor allele frequency- G:0.02NS EA WA 702
    rs41515511,2
    C,F,H--29928499(+) TGGAGG/TTGGAA 3 -- ut3120Minor allele frequency- T:0.04NS NA EA 1758

    HapMap Linkage Disequilibrium report for LPAR6 (48963707 - 49018840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LPAR6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747380CNV Deletion23290073
    esv2747379CNV Deletion23290073
    esv1206120CNV Deletion17803354
    esv1248194CNV Deletion17803354
    esv2747378CNV Deletion23290073
    nsv832602CNV Loss17160897
    esv29390CNV Gain19812545

    Human Gene Mutation Database (HGMD): LPAR6
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing LPAR6:
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing LPAR6
    DNA2.0 Custom Variant and Variant Library Synthesis for LPAR6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609239   
    OMIM disorders: 278150  
    UniProtKB/Swiss-Prot: LPAR6_HUMAN, P43657
  • Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150]: A hair shaft
    disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some
    populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair
    shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit
    features of hypotrichosis. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Hypotrichosis 8 (HYPT8) [MIM:278150]: A condition characterized by the presence of less than the normal
    amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the
    trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard,
    pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular
    papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis,
    monilethrix-like hairs showing elliptical nodes have been observed. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 15 diseases for LPAR6:    
    About MalaCards
    hypotrichosis 8    woolly hair, autosomal recessive    woolly hair, autosomal recessive 1, with or without hypotrichosis    woolly hair, autosomal dominant
    autosomal recessive hypotrichosis    hypotrichosis simplex    hypotrichosis 11    hypotrichosis
    retinoblastoma    epididymitis    chronic lymphocytic leukemia    multiple myeloma
    myeloma    leukemia    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for LPAR6:
    Hypotrichosis

    LPAR6 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: LPAR6 (1 document)

    Export disorders for LPAR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LPAR6 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with LPAR6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PubMed id 11004484)1, 2, 3 Adrian K.... Ogilvie A. (Biochim. Biophys. Acta 2000)
    2. Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. (PubMed id 19386608)1, 3 Yanagida K....Ishii S. (J. Biol. Chem. 2009)
    3. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. (PubMed id 18297070)1, 2 Pasternack S.M.... Betz R.C. (Nat. Genet. 2008)
    4. Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. (PubMed id 18297072)1, 2 Shimomura Y....Christiano A.M. (Nat. Genet. 2008)
    5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Receptors for purines and pyrimidines. (PubMed id 9755289)1, 3 Ralevic V. and Burnstock G. (Pharmacol. Rev. 1998)
    9. Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene. (PubMed id 8889552)1, 2 Herzog H.... Shine J. (Genome Res. 1996)
    10. Complete genomic sequence of the human retinoblastoma susceptibility gene. (PubMed id 7902321)1, 2 Toguchida J.... Dryja T.P. (Genomics 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10161 HGNC: 15520 AceView: P2RY5 Ensembl:ENSG00000139679 euGenes: HUgn10161
    ECgene: LPAR6 Kegg: 10161 H-InvDB: LPAR6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LPAR6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LPAR6 gene:
    Search GeneIP for patents involving LPAR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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