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Aliases for LPAR6 Gene

Aliases for LPAR6 Gene

  • Lysophosphatidic Acid Receptor 6 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 5 2 3
  • Oleoyl-L-Alpha-Lysophosphatidic Acid Receptor 3 4
  • RB Intron Encoded G-Protein Coupled Receptor 3 4
  • Purinergic Receptor 5 3 4
  • P2Y Purinoceptor 5 3 4
  • LPA Receptor 6 3 4
  • P2RY5 3 4
  • LPA-6 3 4
  • P2Y5 3 4
  • Purinergic Receptor P2Y G Protein-Coupled Protein 5 3
  • G-Protein Coupled Purinergic Receptor P2Y5 3
  • ARWH1 3
  • HYPT8 3
  • LAH3 3

External Ids for LPAR6 Gene

Previous HGNC Symbols for LPAR6 Gene

  • P2RY5

Previous GeneCards Identifiers for LPAR6 Gene

  • GC13M047885
  • GC13M048963
  • GC13M029777

Summaries for LPAR6 Gene

Entrez Gene Summary for LPAR6 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

GeneCards Summary for LPAR6 Gene

LPAR6 (Lysophosphatidic Acid Receptor 6) is a Protein Coding gene. Diseases associated with LPAR6 include Hypotrichosis 8 and Woolly Hair Syndrome. Among its related pathways are Peptide ligand-binding receptors and Nucleotide-like (purinergic) receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for LPAR6 Gene

  • Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.

Gene Wiki entry for LPAR6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR6 Gene

Genomics for LPAR6 Gene

Regulatory Elements for LPAR6 Gene

Enhancers for LPAR6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LPAR6 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPAR6 Gene

48,389,567 bp from pter
48,444,704 bp from pter
55,138 bases
Minus strand

Genomic View for LPAR6 Gene

Genes around LPAR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR6 Gene

Proteins for LPAR6 Gene

  • Protein details for LPAR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysophosphatidic acid receptor 6
    Protein Accession:
    Secondary Accessions:
    • A4FTW9
    • B3KVF2
    • F2YGU4
    • O15133
    • Q3KPF5
    • Q53FA0
    • Q5VW44
    • Q7Z3S0
    • Q7Z3S6

    Protein attributes for LPAR6 Gene

    344 amino acids
    Molecular mass:
    39392 Da
    Quaternary structure:
    No Data Available
    • This is a nested gene within intron 17 of the retinoblastoma gene.
    • Sequence=L11910; Type=Frameshift; Positions=31; Evidence={ECO:0000305};

neXtProt entry for LPAR6 Gene

Proteomics data for LPAR6 Gene at MOPED

Post-translational modifications for LPAR6 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for LPAR6 Gene

No data available for DME Specific Peptides for LPAR6 Gene

Domains & Families for LPAR6 Gene

Gene Families for LPAR6 Gene

Protein Domains for LPAR6 Gene

Suggested Antigen Peptide Sequences for LPAR6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR6: view

Function for LPAR6 Gene

Molecular function for LPAR6 Gene

UniProtKB/Swiss-Prot Function:
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
genes like me logo Genes that share phenotypes with LPAR6: view

Human Phenotype Ontology for LPAR6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for LPAR6 Gene

MGI Knock Outs for LPAR6:

Animal Model Products

  • Taconic Biosciences Mouse Models for LPAR6

CRISPR Products

miRNA for LPAR6 Gene

miRTarBase miRNAs that target LPAR6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for LPAR6 Gene

Localization for LPAR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LPAR6 Gene COMPARTMENTS Subcellular localization image for LPAR6 gene
Compartment Confidence
plasma membrane 5
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for LPAR6 Gene

Pathways & Interactions for LPAR6 Gene

genes like me logo Genes that share pathways with LPAR6: view

Interacting Proteins for LPAR6 Gene

Gene Ontology (GO) - Biological Process for LPAR6 Gene


No data available for SIGNOR curated interactions for LPAR6 Gene

Drugs & Compounds for LPAR6 Gene

(4) Drugs for LPAR6 Gene - From: ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
MC-1 Investigational Pharma 0
LPA Pharma Agonist 0
Ki16425 Pharma Antagonist LPA receptor antagonist 0

(20) Additional Compounds for LPAR6 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate

(10) Tocris Compounds for LPAR6 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Endogenous agonist of LPA1 and LPA2 325465-93-8
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
2-Methylthioadenosine triphosphate tetrasodium salt P2 purinergic agonist 100020-57-3
GRI 977143 Selective LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(1) ApexBio Compounds for LPAR6 Gene

Compound Action Cas Number
Ki16425 LPA receptor antagonist 355025-24-0
genes like me logo Genes that share compounds with LPAR6: view

Transcripts for LPAR6 Gene

Unigene Clusters for LPAR6 Gene

Lysophosphatidic acid receptor 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR6 Gene

No ASD Table

Relevant External Links for LPAR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LPAR6 Gene

mRNA expression in normal human tissues for LPAR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LPAR6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LPAR6 Gene

SOURCE GeneReport for Unigene cluster for LPAR6 Gene Hs.123464

mRNA Expression by UniProt/SwissProt for LPAR6 Gene

Tissue specificity: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henles and Huxleys layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with LPAR6: view

Protein tissue co-expression partners for LPAR6 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for LPAR6 Gene

Orthologs for LPAR6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LPAR6 35
  • 88 (n)
  • 89.68 (a)
P2RY5 36
  • 89 (a)
(Canis familiaris)
Mammalia LPAR6 35
  • 91.46 (n)
  • 91.16 (a)
LPAR6 36
  • 90 (a)
(Mus musculus)
Mammalia Lpar6 35
  • 87.76 (n)
  • 93.29 (a)
Lpar6 16
Lpar6 36
  • 93 (a)
(Pan troglodytes)
Mammalia LPAR6 35
  • 100 (n)
  • 100 (a)
LPAR6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Lpar6 35
  • 87.17 (n)
  • 93.29 (a)
(Monodelphis domestica)
Mammalia LPAR6 36
  • 88 (a)
(Gallus gallus)
Aves LPAR6 35
  • 72.01 (n)
  • 79.23 (a)
-- 36
  • 18 (a)
(Anolis carolinensis)
Reptilia LPAR6 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar6 35
  • 73.31 (n)
  • 80.06 (a)
(Danio rerio)
Actinopterygii lpar6a 35
  • 62.03 (n)
  • 64.2 (a)
lpar6a 36
  • 61 (a)
lpar6b 36
  • 56 (a)
Species with no ortholog for LPAR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR6 Gene

Gene Tree for LPAR6 (if available)
Gene Tree for LPAR6 (if available)

Paralogs for LPAR6 Gene

genes like me logo Genes that share paralogs with LPAR6: view

Variants for LPAR6 Gene

Sequence variations from dbSNP and Humsavar for LPAR6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_016253 -
VAR_022636 -
VAR_044326 Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)
VAR_044327 Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)
VAR_044328 Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)

Structural Variations from Database of Genomic Variants (DGV) for LPAR6 Gene

Variant ID Type Subtype PubMed ID
esv29390 CNV Gain 19812545
esv2747378 CNV Deletion 23290073
esv1206120 CNV Deletion 17803354
esv1248194 CNV Deletion 17803354
esv2747379 CNV Deletion 23290073
esv2747380 CNV Deletion 23290073
nsv832602 CNV Loss 17160897

Variation tolerance for LPAR6 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPAR6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR6 Gene

Disorders for LPAR6 Gene

MalaCards: The human disease database

(7) MalaCards diseases for LPAR6 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypotrichosis 8
  • woolly hair, autosomal recessive 1, with or without hypotrichosis
woolly hair syndrome
  • familial woolly hair
hypotrichosis simplex
  • hhs
woolly hair, autosomal recessive
- elite association - COSMIC cancer census association via MalaCards
Search LPAR6 in MalaCards View complete list of genes associated with diseases


  • Hypotrichosis 8 (HYPT8) [MIM:278150]: A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed. {ECO:0000269 PubMed:18297070}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis. {ECO:0000269 PubMed:18297072}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for LPAR6

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LPAR6: view

No data available for Genatlas for LPAR6 Gene

Publications for LPAR6 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K. … Ogilvie A. (Biochim. Biophys. Acta 2000) 2 3 4 67
  2. Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. (PMID: 19386608) Yanagida K. … Ishii S. (J. Biol. Chem. 2009) 2 3
  3. Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in the P2RY5 gene. (PMID: 18803659) Shimomura Y. … Christiano A.M. (Exp. Dermatol. 2009) 3 23
  4. ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts. (PMID: 15582581) Ihara H. … Togari A. (Biochem. Biophys. Res. Commun. 2005) 3 23
  5. Receptors for purines and pyrimidines. (PMID: 9755289) Ralevic V. … Burnstock G. (Pharmacol. Rev. 1998) 2 3

Products for LPAR6 Gene

Sources for LPAR6 Gene