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Aliases for LPAR5 Gene

Aliases for LPAR5 Gene

  • Lysophosphatidic Acid Receptor 5 2 3 5
  • G Protein-Coupled Receptor 92 2 3
  • G-Protein Coupled Receptor 93 3 4
  • LPA Receptor 5 3 4
  • GPR92 3 4
  • GPR93 3 4
  • LPA-5 3 4
  • G-Protein Coupled Receptor 92 4
  • KPG_010 3
  • LPA5 3

External Ids for LPAR5 Gene

Previous HGNC Symbols for LPAR5 Gene

  • GPR93
  • GPR92

Previous GeneCards Identifiers for LPAR5 Gene

  • GC12M006599
  • GC12M006728

Summaries for LPAR5 Gene

Entrez Gene Summary for LPAR5 Gene

  • This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]

GeneCards Summary for LPAR5 Gene

LPAR5 (Lysophosphatidic Acid Receptor 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is LPAR6.

UniProtKB/Swiss-Prot for LPAR5 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Gene Wiki entry for LPAR5 Gene

Additional gene information for LPAR5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR5 Gene

Genomics for LPAR5 Gene

Regulatory Elements for LPAR5 Gene

Enhancers for LPAR5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006637 1.4 Ensembl ENCODE dbSUPER 23.3 -2.6 -2596 2.1 HDGF PKNOX1 ATF1 ARNT TCF12 GATA2 FOS ATF7 NCOA1 SMARCB1 LPAR5 ZNF384 ACRBP
GH12H006630 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.2 +3.8 3794 4.1 PKNOX1 ZBTB21 NFIB IRF3 BACH1 EBF1 ZNF121 POLR2A ZBTB48 EED LPAR5 TAPBPL MRPL51 LAG3 VAMP1 LOC105369631
GH12H006602 1.7 FANTOM5 ENCODE dbSUPER 12.8 +30.7 30720 7.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF384 ENSG00000219410 ENSG00000247853 CHD4 NOP2 ING4 NCAPD2 SPSB2 EMG1 SCARNA12
GH12H006788 1.5 FANTOM5 ENCODE dbSUPER 12.8 -154.6 -154630 5 ELF3 HDGF FOXA2 MLX ARID4B RAD21 THRB RARA YY1 SLC30A9 CD4 LPAR5 GPR162 P3H3 PTPN6 ING4 PTMS MLF2 GNB3 PIANP
GH12H006331 1.8 FANTOM5 ENCODE dbSUPER 9.5 +298.3 298309 12.7 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ENSG00000219410 ZNF384 ENSG00000247853 NCAPD2 CHD4 ING4 SPSB2 VAMP1 TAPBPL LTBR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LPAR5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LPAR5 Gene

Genomic Locations for LPAR5 Gene
chr12:6,618,835-6,636,447
(GRCh38/hg38)
Size:
17,613 bases
Orientation:
Minus strand
chr12:6,728,001-6,745,613
(GRCh37/hg19)

Genomic View for LPAR5 Gene

Genes around LPAR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR5 Gene

Proteins for LPAR5 Gene

  • Protein details for LPAR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1C0-LPAR5_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 5
    Protein Accession:
    Q9H1C0

    Protein attributes for LPAR5 Gene

    Size:
    372 amino acids
    Molecular mass:
    41347 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAR5 Gene

Post-translational modifications for LPAR5 Gene

  • Glycosylation at Asn4 and Asn9
  • Modification sites at PhosphoSitePlus

Other Protein References for LPAR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LPAR5 Gene

Domains & Families for LPAR5 Gene

Gene Families for LPAR5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for LPAR5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1C0

UniProtKB/Swiss-Prot:

LPAR5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR5: view

Function for LPAR5 Gene

Molecular function for LPAR5 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Phenotypes From GWAS Catalog for LPAR5 Gene

Gene Ontology (GO) - Molecular Function for LPAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with LPAR5: view
genes like me logo Genes that share phenotypes with LPAR5: view

Animal Models for LPAR5 Gene

MGI Knock Outs for LPAR5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LPAR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LPAR5 Gene

Localization for LPAR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPAR5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for LPAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPAR5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LPAR5 Gene

Pathways & Interactions for LPAR5 Gene

genes like me logo Genes that share pathways with LPAR5: view

Gene Ontology (GO) - Biological Process for LPAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LPAR5: view

No data available for SIGNOR curated interactions for LPAR5 Gene

Drugs & Compounds for LPAR5 Gene

(11) Drugs for LPAR5 Gene - From: ApexBio, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Antagonist 0
AM966 Pharma Antagonist LPA1 antagonist, oral active, high affinity, selective, 0
farnesyl monophosphate Pharma Antagonist 0
LPA Pharma Agonist 0
1-Oleoyl lysophosphatidic acid sodium salt Pharma Activates LPA receptor 0

(10) Additional Compounds for LPAR5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate

(5) Tocris Compounds for LPAR5 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Endogenous agonist of LPA1 and LPA2 325465-93-8
GRI 977143 Selective LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(6) ApexBio Compounds for LPAR5 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Activates LPA receptor 325465-93-8
H2L 5765834 420841-84-5
H2L5186303 139262-76-3
Ki16198 LPA antagonist 355025-13-7
Ki16425 LPA receptor antagonist 355025-24-0
TC LPA5 4 1393814-38-4
genes like me logo Genes that share compounds with LPAR5: view

Drug Products

Transcripts for LPAR5 Gene

Unigene Clusters for LPAR5 Gene

Lysophosphatidic acid receptor 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LPAR5

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR5 Gene

No ASD Table

Relevant External Links for LPAR5 Gene

GeneLoc Exon Structure for
LPAR5
ECgene alternative splicing isoforms for
LPAR5

Expression for LPAR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPAR5 Gene

mRNA differential expression in normal tissues according to GTEx for LPAR5 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.6).

Protein differential expression in normal tissues from HIPED for LPAR5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (52.2) and Blymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LPAR5 Gene



Protein tissue co-expression partners for LPAR5 Gene

NURSA nuclear receptor signaling pathways regulating expression of LPAR5 Gene:

LPAR5

SOURCE GeneReport for Unigene cluster for LPAR5 Gene:

Hs.155538

mRNA Expression by UniProt/SwissProt for LPAR5 Gene:

Q9H1C0-LPAR5_HUMAN
Tissue specificity: Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.

Evidence on tissue expression from TISSUES for LPAR5 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with LPAR5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR5 Gene

Orthologs for LPAR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPAR5 33 34
  • 98.75 (n)
dog
(Canis familiaris)
Mammalia LPAR5 33 34
  • 86.26 (n)
cow
(Bos Taurus)
Mammalia LPAR5 33 34
  • 83.65 (n)
rat
(Rattus norvegicus)
Mammalia Lpar5 33
  • 81.24 (n)
mouse
(Mus musculus)
Mammalia Lpar5 33 16 34
  • 80.78 (n)
oppossum
(Monodelphis domestica)
Mammalia LPAR5 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPAR5 33 34
  • 57.56 (n)
lizard
(Anolis carolinensis)
Reptilia LPAR5 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar5 33
  • 56.55 (n)
zebrafish
(Danio rerio)
Actinopterygii lpar5a 34
  • 33 (a)
ManyToMany
Species where no ortholog for LPAR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR5 Gene

ENSEMBL:
Gene Tree for LPAR5 (if available)
TreeFam:
Gene Tree for LPAR5 (if available)

Paralogs for LPAR5 Gene

Paralogs for LPAR5 Gene

(15) SIMAP similar genes for LPAR5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LPAR5: view

Variants for LPAR5 Gene

Sequence variations from dbSNP and Humsavar for LPAR5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000091978 -- 6,622,764(+) AAAAA(A/T)ATTAA intron-variant
rs1000112868 -- 6,635,084(+) TCTGT(C/G)TCAAA intron-variant
rs1000220212 -- 6,628,606(+) CAGGC(A/G)CTCAC intron-variant
rs1000323201 -- 6,626,422(+) GTTTT(C/T)CTTGT intron-variant
rs1000340413 -- 6,632,361(+) TCCCC(A/G)TCCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LPAR5 Gene

Variant ID Type Subtype PubMed ID
nsv832322 CNV loss 17160897
nsv557256 CNV loss 21841781
nsv509452 CNV insertion 20534489

Variation tolerance for LPAR5 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPAR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPAR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR5 Gene

Disorders for LPAR5 Gene

Relevant External Links for LPAR5

Genetic Association Database (GAD)
LPAR5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPAR5

No disorders were found for LPAR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPAR5 Gene

Publications for LPAR5 Gene

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4 60
  2. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. (PMID: 11062477) ADHR Consortium (Nature genetics 2000) 2 3 4 60
  3. Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. (PMID: 16651401) Kotarsky K … Olde B (The Journal of pharmacology and experimental therapeutics 2006) 2 3 60
  4. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. (PMID: 16774927) Lee CW … Chun J (The Journal of biological chemistry 2006) 2 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for LPAR5 Gene

  • Addgene plasmids for LPAR5

Sources for LPAR5 Gene

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