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Aliases for LPAR5 Gene

Aliases for LPAR5 Gene

  • Lysophosphatidic Acid Receptor 5 2 3 5
  • G Protein-Coupled Receptor 92 2 3
  • G-Protein Coupled Receptor 92 3 4
  • G-Protein Coupled Receptor 93 3 4
  • LPA Receptor 5 3 4
  • GPR92 3 4
  • GPR93 3 4
  • LPA-5 3 4
  • KPG_010 3
  • LPA5 3

External Ids for LPAR5 Gene

Previous HGNC Symbols for LPAR5 Gene

  • GPR93
  • GPR92

Previous GeneCards Identifiers for LPAR5 Gene

  • GC12M006599
  • GC12M006728

Summaries for LPAR5 Gene

Entrez Gene Summary for LPAR5 Gene

  • This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]

GeneCards Summary for LPAR5 Gene

LPAR5 (Lysophosphatidic Acid Receptor 5) is a Protein Coding gene. Among its related pathways are Pathways in cancer and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is LPAR6.

UniProtKB/Swiss-Prot for LPAR5 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Gene Wiki entry for LPAR5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR5 Gene

Genomics for LPAR5 Gene

Regulatory Elements for LPAR5 Gene

Enhancers for LPAR5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around LPAR5 on UCSC Golden Path with GeneCards custom track

Promoters for LPAR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LPAR5 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPAR5 Gene

Chromosome:
12
Start:
6,618,835 bp from pter
End:
6,636,447 bp from pter
Size:
17,613 bases
Orientation:
Minus strand

Genomic View for LPAR5 Gene

Genes around LPAR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR5 Gene

Proteins for LPAR5 Gene

  • Protein details for LPAR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1C0-LPAR5_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 5
    Protein Accession:
    Q9H1C0

    Protein attributes for LPAR5 Gene

    Size:
    372 amino acids
    Molecular mass:
    41347 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAR5 Gene

Post-translational modifications for LPAR5 Gene

  • Glycosylation at Asn 4 and Asn 9
  • Modification sites at PhosphoSitePlus

Other Protein References for LPAR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LPAR5 Gene

Domains & Families for LPAR5 Gene

Gene Families for LPAR5 Gene

Protein Domains for LPAR5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H1C0

UniProtKB/Swiss-Prot:

LPAR5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR5: view

Function for LPAR5 Gene

Molecular function for LPAR5 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Gene Ontology (GO) - Molecular Function for LPAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with LPAR5: view
genes like me logo Genes that share phenotypes with LPAR5: view

Animal Models for LPAR5 Gene

MGI Knock Outs for LPAR5:

Animal Model Products

  • Taconic Biosciences Mouse Models for LPAR5

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LPAR5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LPAR5 Gene

Localization for LPAR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPAR5 Gene COMPARTMENTS Subcellular localization image for LPAR5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for LPAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPAR5: view

Pathways & Interactions for LPAR5 Gene

genes like me logo Genes that share pathways with LPAR5: view

Gene Ontology (GO) - Biological Process for LPAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LPAR5: view

No data available for SIGNOR curated interactions for LPAR5 Gene

Drugs & Compounds for LPAR5 Gene

(11) Drugs for LPAR5 Gene - From: ApexBio, DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Antagonist 0
H2L 5765834 Pharma LPA1,3,5 antagonist 0
H2L5186303 Pharma Potent and selective LPA2 receptor antagonist 0
Ki16425 Pharma Antagonist LPA receptor antagonist, LPA1 and LPA3 receptor antagonist 0
TC LPA5 4 Pharma LPA5 receptor antagonist 0

(10) Additional Compounds for LPAR5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate

(4) Tocris Compounds for LPAR5 Gene

Compound Action Cas Number
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
Ki 16425 LPA1 and LPA3 receptor antagonist 355025-24-0
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(6) ApexBio Compounds for LPAR5 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Activates LPA receptor 325465-93-8
H2L 5765834 420841-84-5
H2L5186303 139262-76-3
Ki16198 LPA antagonist 355025-13-7
Ki16425 LPA receptor antagonist 355025-24-0
TC LPA5 4 1393814-38-4
genes like me logo Genes that share compounds with LPAR5: view

Transcripts for LPAR5 Gene

Unigene Clusters for LPAR5 Gene

Lysophosphatidic acid receptor 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LPAR5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR5 Gene

No ASD Table

Relevant External Links for LPAR5 Gene

GeneLoc Exon Structure for
LPAR5
ECgene alternative splicing isoforms for
LPAR5

Expression for LPAR5 Gene

mRNA expression in normal human tissues for LPAR5 Gene

mRNA differential expression in normal tissues according to GTEx for LPAR5 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.6).

Protein differential expression in normal tissues from HIPED for LPAR5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (52.2) and Blymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LPAR5 Gene



Protein tissue co-expression partners for LPAR5 Gene

NURSA nuclear receptor signaling pathways regulating expression of LPAR5 Gene:

LPAR5

SOURCE GeneReport for Unigene cluster for LPAR5 Gene:

Hs.155538

mRNA Expression by UniProt/SwissProt for LPAR5 Gene:

Q9H1C0-LPAR5_HUMAN
Tissue specificity: Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.
genes like me logo Genes that share expression patterns with LPAR5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LPAR5 Gene

Orthologs for LPAR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPAR5 34
  • 83.65 (n)
  • 79.73 (a)
LPAR5 35
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPAR5 34
  • 86.26 (n)
  • 81.59 (a)
LPAR5 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpar5 34
  • 80.78 (n)
  • 81.42 (a)
Lpar5 16
Lpar5 35
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPAR5 34
  • 98.75 (n)
  • 99.19 (a)
LPAR5 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpar5 34
  • 81.24 (n)
  • 80.33 (a)
oppossum
(Monodelphis domestica)
Mammalia LPAR5 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPAR5 34
  • 57.56 (n)
  • 53.49 (a)
LPAR5 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPAR5 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar5 34
  • 56.55 (n)
  • 51.16 (a)
zebrafish
(Danio rerio)
Actinopterygii lpar5a 35
  • 33 (a)
ManyToMany
Species where no ortholog for LPAR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR5 Gene

ENSEMBL:
Gene Tree for LPAR5 (if available)
TreeFam:
Gene Tree for LPAR5 (if available)

Paralogs for LPAR5 Gene

(15) SIMAP similar genes for LPAR5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LPAR5: view

Variants for LPAR5 Gene

Sequence variations from dbSNP and Humsavar for LPAR5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1922454 -- 6,633,394(+) GCCGG(C/T)TCCTT intron-variant, upstream-variant-2KB
rs7315856 -- 6,624,330(+) aacaa(A/C)aaaga intron-variant
rs2141879 -- 6,637,457(+) AAAAT(A/T)TAAAA upstream-variant-2KB
rs2141880 -- 6,637,474(+) CAGGC(A/G/T)TAGTG upstream-variant-2KB
rs11438544 -- 6,635,086(+) AAAAA(-/A)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPAR5 Gene

Variant ID Type Subtype PubMed ID
nsv509452 CNV insertion 20534489
nsv557256 CNV loss 21841781
nsv832322 CNV loss 17160897

Variation tolerance for LPAR5 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPAR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPAR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR5 Gene

Disorders for LPAR5 Gene

Relevant External Links for LPAR5

Genetic Association Database (GAD)
LPAR5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPAR5

No disorders were found for LPAR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPAR5 Gene

Publications for LPAR5 Gene

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee D.K. … O'Dowd B.F. (Gene 2001) 2 3 4 65
  2. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. (PMID: 11062477) White K.E. … Strom T.M. (Nat. Genet. 2000) 2 3 4 65
  3. Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. (PMID: 16651401) Kotarsky K. … Olde B. (J. Pharmacol. Exp. Ther. 2006) 2 3 65
  4. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. (PMID: 16774927) Lee C.W. … Chun J. (J. Biol. Chem. 2006) 2 3 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for LPAR5 Gene

Sources for LPAR5 Gene

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