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Aliases for LPAR5 Gene

Aliases for LPAR5 Gene

  • Lysophosphatidic Acid Receptor 5 2 3
  • GPR92 3 4 6
  • GPR93 3 4 6
  • G Protein-Coupled Receptor 92 2 3
  • G-Protein Coupled Receptor 92 3 4
  • G-Protein Coupled Receptor 93 3 4
  • LPA Receptor 5 3 4
  • LPA-5 3 4
  • LPA5 3 6
  • KPG_010 3

External Ids for LPAR5 Gene

Previous HGNC Symbols for LPAR5 Gene

  • GPR93
  • GPR92

Previous GeneCards Identifiers for LPAR5 Gene

  • GC12M006599
  • GC12M006728

Summaries for LPAR5 Gene

Entrez Gene Summary for LPAR5 Gene

  • This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]

GeneCards Summary for LPAR5 Gene

LPAR5 (Lysophosphatidic Acid Receptor 5) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for LPAR5 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities

Gene Wiki entry for LPAR5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR5 Gene

Genomics for LPAR5 Gene

Regulatory Elements for LPAR5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LPAR5 Gene

Start:
6,618,835 bp from pter
End:
6,636,447 bp from pter
Size:
17,613 bases
Orientation:
Minus strand

Genomic View for LPAR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPAR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR5 Gene

Proteins for LPAR5 Gene

  • Protein details for LPAR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1C0-LPAR5_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 5
    Protein Accession:
    Q9H1C0
    Secondary Accessions:

    Protein attributes for LPAR5 Gene

    Size:
    372 amino acids
    Molecular mass:
    41347 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAR5 Gene

Proteomics data for LPAR5 Gene at MOPED

Post-translational modifications for LPAR5 Gene

  • Glycosylation at Asn4 and Asn9
  • Modification sites at PhosphoSitePlus

Other Protein References for LPAR5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LPAR5 Gene

Domains for LPAR5 Gene

Gene Families for LPAR5 Gene

HGNC:
  • LPAR :GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid
IUPHAR :

Protein Domains for LPAR5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LPAR5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1C0

UniProtKB/Swiss-Prot:

LPAR5_HUMAN :
  • Q9H1C0
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR5: view

Function for LPAR5 Gene

Molecular function for LPAR5 Gene

UniProtKB/Swiss-Prot Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities

Gene Ontology (GO) - Molecular Function for LPAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with LPAR5: view
genes like me logo Genes that share phenotypes with LPAR5: view

Animal Models for LPAR5 Gene

MGI Knock Outs for LPAR5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LPAR5 Gene

Localization for LPAR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPAR5 Gene COMPARTMENTS Subcellular localization image for LPAR5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for LPAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPAR5: view

Pathways for LPAR5 Gene

genes like me logo Genes that share pathways with LPAR5: view

Pathways by source for LPAR5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for LPAR5 Gene

Gene Ontology (GO) - Biological Process for LPAR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LPAR5: view

Compounds for LPAR5 Gene

(5) Tocris Compounds for LPAR5 Gene

Compound Action Cas Number
GRI 977143 Selective LPA2 receptor non-lipid agonist [325850-81-5]
H2L 5765834 LPA1,3,5 antagonist [420841-84-5]
H2L5186303 Potent and selective LPA2 receptor antagonist [139262-76-3]
Ki 16425 LPA1 and LPA3 receptor antagonist [355025-24-0]
TC LPA5 4 LPA5 receptor antagonist [1393814-38-4]

(10) HMDB Compounds for LPAR5 Gene

Compound Synonyms Cas Number PubMed IDs
LPA(0:0/16:0)
  • Lysophosphatidic acid(16:0)
Not Available
LPA(0:0/18:0)
  • 2-octadecanoyl-phosphatidic acid
Not Available
LPA(0:0/18:1(9Z))
  • LPA(18:1)
Not Available
LPA(0:0/18:2(9Z,12Z))
  • LPA(0:0/18:2n6)
Not Available
LPA(16:0/0:0)
  • Lysophosphatidic acid(16:0/0:0)
Not Available

(4) IUPHAR Ligand for LPAR5 Gene

Ligand Type Action Affinity Pubmed IDs
farnesyl diphosphate Antagonist Antagonist 6.81
farnesyl monophosphate Antagonist Antagonist 6.3
AM966 Antagonist Antagonist 5.7
LPA Agonist Agonist 5.6
genes like me logo Genes that share compounds with LPAR5: view

Transcripts for LPAR5 Gene

Unigene Clusters for LPAR5 Gene

Lysophosphatidic acid receptor 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPAR5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR5 Gene

No ASD Table

Relevant External Links for LPAR5 Gene

GeneLoc Exon Structure for
LPAR5
ECgene alternative splicing isoforms for
LPAR5

Expression for LPAR5 Gene

mRNA expression in normal human tissues for LPAR5 Gene

mRNA differential expression in normal tissues according to GTEx for LPAR5 Gene

This gene is overexpressed in Esophagus - Mucosa (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LPAR5 Gene

SOURCE GeneReport for Unigene cluster for LPAR5 Gene Hs.155538

mRNA Expression by UniProt/SwissProt for LPAR5 Gene

Q9H1C0-LPAR5_HUMAN
Tissue specificity: Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus
genes like me logo Genes that share expressions with LPAR5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LPAR5 Gene

Orthologs for LPAR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPAR5 35
  • 98.75 (n)
  • 99.19 (a)
LPAR5 36
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPAR5 35
  • 83.65 (n)
  • 79.73 (a)
LPAR5 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPAR5 35
  • 86.26 (n)
  • 81.59 (a)
LPAR5 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpar5 35
  • 80.78 (n)
  • 81.42 (a)
Lpar5 16
Lpar5 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPAR5 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpar5 35
  • 81.24 (n)
  • 80.33 (a)
chicken
(Gallus gallus)
Aves LPAR5 35
  • 57.56 (n)
  • 53.49 (a)
LPAR5 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPAR5 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar5 35
  • 56.55 (n)
  • 51.16 (a)
zebrafish
(Danio rerio)
Actinopterygii lpar5a 36
  • 33 (a)
ManyToMany
Species with no ortholog for LPAR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR5 Gene

ENSEMBL:
Gene Tree for LPAR5 (if available)
TreeFam:
Gene Tree for LPAR5 (if available)

Paralogs for LPAR5 Gene

Selected SIMAP similar genes for LPAR5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LPAR5: view

Variants for LPAR5 Gene

Sequence variations from dbSNP and Humsavar for LPAR5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11612 -- 6,618,999(+) TCCAC(A/G)AGGTC utr-variant-3-prime
rs1057069 -- 6,619,140(-) acaca(G/T)tacat utr-variant-3-prime
rs1922454 -- 6,633,394(+) GCCGG(C/T)TCCTT upstream-variant-2KB, intron-variant
rs2141879 -- 6,637,457(+) AAAAT(A/T)TAAAA upstream-variant-2KB
rs2141880 -- 6,637,474(+) CAGGC(G/T)TAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LPAR5 Gene

Variant ID Type Subtype PubMed ID
nsv509452 CNV Insertion 20534489
nsv832322 CNV Loss 17160897

Relevant External Links for LPAR5 Gene

HapMap Linkage Disequilibrium report
LPAR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR5 Gene

Disorders for LPAR5 Gene

Relevant External Links for LPAR5

Genetic Association Database (GAD)
LPAR5
genes like me logo Genes that share disorders with LPAR5: view

No data available for UniProtKB/Swiss-Prot for LPAR5 Gene

Publications for LPAR5 Gene

  1. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. (PMID: 11062477) White K.E. … Strom T.M. (Nat. Genet. 2000) 2 3 4
  2. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee D.K. … O'Dowd B.F. (Gene 2001) 2 3 4
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. (PMID: 16651401) Kotarsky K. … Olde B. (J. Pharmacol. Exp. Ther. 2006) 2 3

Products for LPAR5 Gene

Sources for LPAR5 Gene

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