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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LPAR5 Gene

protein-coding   GIFtS: 53
GCID: GC12M006728

Lysophosphatidic Acid Receptor 5

(Previous name: G protein-coupled receptor 92)
(Previous symbols: GPR93, GPR92)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysophosphatidic Acid Receptor 51 2     G-Protein Coupled Receptor 922 3
GPR921 2 3 5     G-Protein Coupled Receptor 932 3
GPR931 2 3 5     LPA Receptor 52 3
G Protein-Coupled Receptor 921 2     LPA52 5
LPA-52 3     KPG_0102

External Ids:    HGNC: 133071   Entrez Gene: 571212   Ensembl: ENSG000001845747   OMIM: 6069265   UniProtKB: Q9H1C03   

Export aliases for LPAR5 gene to outside databases

Previous GC identifer: GC12M006599


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LPAR5 Gene:
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein
transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and
mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs.
Transcript variants of this gene have been described.(provided by RefSeq, Dec 2008)

GeneCards Summary for LPAR5 Gene: 
LPAR5 (lysophosphatidic acid receptor 5) is a protein-coding gene. Diseases associated with LPAR5 include rickets, and chronic lymphocytic leukemia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity and molecular_function. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities

Gene Wiki entry for LPAR5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LPAR5 gene promoter:
         MZF-1   HSF2   MyoD   FOXD3   ATF6   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPAR5 promoter sequence
   Search SABiosciences Chromatin IP Primers for LPAR5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPAR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

LPAR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006728:  view genomic region     (about GC identifiers)

Start:
6,728,001 bp from pter      End:
6,745,613 bp from pter
Size:
17,613 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 5  
Size: 372 amino acids; 41347 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for LPAR5: NX_Q9H1C0

Explore proteomics data for LPAR5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H1C0

  • LPAR5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LPAR5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001136433.1  NP_065133.1  

    ENSEMBL proteins: 
     ENSP00000327875   ENSP00000393098  
    Reactome Protein details: Q9H1C0
    Human Recombinant Protein Products for LPAR5: 
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    Novus Biologicals LPAR5 Proteins
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LPAR5 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    LPAR5 for ontologies           About GeneDecksing



    LPAR5 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for LPAR5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LPAR: GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid

    IUPHAR Guide to PHARMACOLOGY protein family classification: LPA5 receptor 
    Lysophospholipid (LPA) receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR002286 purinergic_P2Y_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9H1C0

    ProtoNet protein and cluster: Q9H1C0

    UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    LPAR5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPAR5_HUMAN, Q9H1C0
    Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0045028G-protein coupled purinergic nucleotide receptor activity ----
         
    LPAR5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LPAR5:
     Decreased POU5F1-GFP protein e  Decreased melanin production  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lpar5):
     behavior/neurological  integument  nervous system 

    LPAR5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lpar5tm1Jch for LPAR5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LPAR5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LPAR5

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    miRNA
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    hsa-miR-365 hsa-miR-224 hsa-miR-525-5p hsa-miR-3185 hsa-miR-520g hsa-miR-520a-5p hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidLPAR5 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LPAR5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.46
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.41
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway
    5Lysosphingolipid and LPA receptors
    Lysosphingolipid and LPA receptors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for LPAR5
        GPCRs, Class A Rhodopsin-like

    5/9        Reactome Pathways for LPAR5 (see all 9)
        GPCR downstream signaling
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)


    1         Kegg Pathway  (Kegg details for LPAR5):
        PI3K-Akt signaling pathway


    LPAR5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LPAR5

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008150biological_process ND--

    LPAR5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LPAR5

    10 HMDB Compounds for LPAR5    About this table
    CompoundSynonyms CAS #PubMed Ids
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----
    LPA(P-16:0e/0:0)1-(1Z-hexadecenyl)-sn-glycero-3-phosphate;LysoPA(dm16:0e) ----

    4 IUPHAR Ligands for LPAR5 (LPA5 receptor)    About this table 
    LigandTypeActionAffinityPubmed IDs
    LPA
    AgonistAgonist5.4 - 7.9223396314 20056548
    farnesyl diphosphate
    AgonistAgonist7.419366702
    farnesyl monophosphate
    AgonistAgonist7.3119366702
    AM966
    AntagonistAntagonist5.120649573

    Search CenterWatch for drugs/clinical trials and news about LPAR5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LPAR5 gene (2 alternative transcripts): 
    NM_001142961.1  NM_020400.5  

    Unigene Cluster for LPAR5:

    Lysophosphatidic acid receptor 5
    Hs.155538  [show with all ESTs]
    Unigene Representative Sequence: BC072394
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329858(uc001qps.2) ENST00000540335 ENST00000431922(uc009zer.2 uc010sff.1)

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate LPAR5:
    hsa-miR-365 hsa-miR-224 hsa-miR-525-5p hsa-miR-3185 hsa-miR-520g hsa-miR-520a-5p hsa-miR-874
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPAR5
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    Additional mRNA sequence: 

    AB041943.1 AJ272207.1 AK313127.1 BC033571.2 BC072394.1 

    4 DOTS entries:

    DT.431181  DT.121122091  DT.91755582  DT.100758350 

    24/139 AceView cDNA sequences (see all 139):

    BI826973 BM553134 NM_020400 BI520382 BI829508 BI829361 BI830966 AF085884 
    BI828365 AJ272207 BI829134 AI024421 BC072394 BI520377 NM_032489 BI829306 
    AA769338 BI830306 BM553910 BI825892 BI828527 BI520181 BI520136 BC033010 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LPAR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAACTTCT
    LPAR5 Expression
    About this image


    See LPAR5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LPAR5

    SOURCE GeneReport for Unigene cluster: Hs.155538

    UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
    Tissue specificity: Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus

        SABiosciences Expression via Pathway-Focused PCR Array including LPAR5: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LPAR5 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lpar51 , 5 lysophosphatidic acid receptor 51, 5 80.78(n)1
    81.42(a)1
      6 (59.21 cM)5
    3818101  NM_001163269.11  NP_001156741.11 
     1250679205 
    chicken
    (Gallus gallus)
    Aves LPAR51 lysophosphatidic acid receptor 5 57.84(n)
    54.17(a)
      418279  XM_416504.3  XP_416504.2 
    lizard
    (Anolis carolinensis)
    Reptilia LPAR56
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343381.1(799511-800878)
    zebrafish
    (Danio rerio)
    Actinopterygii lpar5a6
    CR848737.26
    Uncharacterized protein
    31(a)
    29(a)
    possible ortholog
    possible ortholog
    2(48396762-48398332)
    7(27571674-27572612)


    ENSEMBL Gene Tree for LPAR5 (if available)
    TreeFam Gene Tree for LPAR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LPAR5 gene
    P2RY42  CYSLTR12  LPAR42  CYSLTR22  P2RY22  PTAFR2  OXGR12  P2RY112  
    P2RY12  GPR172  P2RY62  GPR1742  LPAR62  GPR1832  P2RY102  SUCNR12  
    16 SIMAP similar genes for LPAR5 using alignment to 1 protein entry:     LPAR5_HUMAN:
    KPG_010    LPAR6    P2RY5    LPAR4    CXCR2    IL8RB
    CXCR1    GPR17    GPR55    SSTR4    GPR68    CYSLTR2
    GPR183    KPG_011    KPG_007    NPBWR1

    LPAR5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/387 SNPs in LPAR5 are shown (see all 387)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383926771,2
    --6727547(+) TTAGCC/TGGGTG 2 -- ds50010--------
    rs1906227261,2
    --6727603(+) GGAGAA/GTCCTA 2 -- ds50010--------
    rs1424645291,2
    --6727677(+) CAGTGC/TGAGAC 2 -- ds50010--------
    rs1835389891,2
    --6727727(+) AGGTGC/GCCCAT 2 -- ds50010--------
    rs1864690101,2
    --6727728(+) GGTGGC/TCCATT 2 -- ds50010--------
    rs110642891,2
    C,F,H--6727749(+) CCAGCG/ATGCTG 2 -- ds500119Minor allele frequency- A:0.24NS EA NA WA CSA 2056
    rs1463381511,2
    --6727791(+) TCACTA/CTTAAC 2 -- ds50010--------
    rs1483027501,2
    --6727797(+) TTAACC/TTCCCC 2 -- ds50010--------
    rs732648561,2
    C,F--6727896(+) CCACCC/TCCCAG 2 -- ds50013Minor allele frequency- T:0.19WA 122
    rs1415606161,2
    --6727935(+) CTGATA/GTGCCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for LPAR5 (6728001 - 6745613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LPAR5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509452CNV Insertion20534489
    nsv832322CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606926    OMIM disorders: --

    3 diseases for LPAR5:    About MalaCards
    rickets    chronic lymphocytic leukemia    leukemia


    LPAR5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LPAR5

    Export disorders for LPAR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LPAR5 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with LPAR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)1, 2, 3 Lee D.K....O'Dowd B.F. (2001)
    2. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. (PubMed id 11062477)1, 2, 3 White K.E.... Strom T.M. (2000)
    3. Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. (PubMed id 16651401)1, 3 Kotarsky K....Olde B. (2006)
    4. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. (PubMed id 16774927)1, 3 Lee C.W....Chun J. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (2002)
    7. LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1I^ release. (PubMed id 21464938)1 Lundequist A. and Boyce J.A. (2011)
    8. Lysophosphatidic acid 5 receptor induces activation o f Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intesti nal epithelial cells. (PubMed id 21832242)1 Yoo B.K....Yun C.C. (2011)
    9. LPA induces osteoblast differentiation through interp lay of two receptors: LPA1 and LPA4. (PubMed id 20069565)1 Liu Y.B....Billiard J. (2010)
    10. Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelia l growth factor expression. (PubMed id 19860625)1 Kumar S.A....Gibson S.B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57121 HGNC: 13307 AceView: GPR92andACRBP Ensembl:ENSG00000184574 euGenes: HUgn57121
    ECgene: LPAR5 Kegg: 57121 H-InvDB: LPAR5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LPAR5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LPAR5 gene:
    Search GeneIP for patents involving LPAR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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