Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LPAR5 Gene

protein-coding   GIFtS: 52
GCID: GC12M006728

Lysophosphatidic Acid Receptor 5

(Previous name: G protein-coupled receptor 92)
(Previous symbols: GPR93, GPR92)
  Search for LPAR5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Lysophosphatidic Acid Receptor 51 2     G-Protein Coupled Receptor 922 3
GPR921 2 3 5     G-Protein Coupled Receptor 932 3
GPR931 2 3 5     LPA Receptor 52 3
G Protein-Coupled Receptor 921 2     LPA52 5
LPA-52 3     KPG_0102

External Ids:    HGNC: 133071   Entrez Gene: 571212   Ensembl: ENSG000001845747   OMIM: 6069265   UniProtKB: Q9H1C03   

Export aliases for LPAR5 gene to outside databases

Previous GC identifer: GC12M006599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LPAR5 Gene:
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein
transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and
mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs.
Transcript variants of this gene have been described.(provided by RefSeq, Dec 2008)

GeneCards Summary for LPAR5 Gene:
LPAR5 (lysophosphatidic acid receptor 5) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities

Gene Wiki entry for LPAR5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the LPAR5 gene promoter:
         MZF-1   HSF2   MyoD   FOXD3   ATF6   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPAR5 promoter sequence
   Search Chromatin IP Primers for LPAR5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LPAR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

LPAR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006728:  view genomic region     (about GC identifiers)

Start:
6,728,001 bp from pter      End:
6,745,613 bp from pter
Size:
17,613 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 5  
Size: 372 amino acids; 41347 Da

Explore the universe of human proteins at neXtProt for LPAR5: NX_Q9H1C0

Explore proteomics data for LPAR5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4, Asn9
  • Modification sites at PhosphoSitePlus

  • See LPAR5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136433.1  NP_065133.1  

    ENSEMBL proteins: 
     ENSP00000327875   ENSP00000393098  
    Reactome Protein details: Q9H1C0

    LPAR5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LPAR5
    GenScript Custom Purified and Recombinant Proteins Services for LPAR5
    Novus Biologicals LPAR5 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LPAR5

     
    Search eBioscience for Proteins for LPAR5 

    LPAR5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LPAR5
    Browse R&D Systems for Antibodies
    OriGene Antibodies for LPAR5
    OriGene Custom Antibody Services for LPAR5
    Novus Biologicals LPAR5 Antibodies
    Search for Antibodies for LPAR5 at Abcam
    Cloud-Clone Corp. Antibodies for LPAR5
    ThermoFisher Antibodies for LPAR5
    LSBio Antibodies in human, mouse, rat for LPAR5

    LPAR5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LPAR5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LPAR5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LPAR5
    Cloud-Clone Corp. CLIAs for LPAR5
    Search eBioscience for ELISAs for LPAR5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    LPAR: GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid

    IUPHAR Guide to PHARMACOLOGY protein family classification: LPA5 receptor
    Lysophospholipid (LPA) receptors

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9H1C0

    ProtoNet protein and cluster: Q9H1C0

    UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with LPAR5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPAR5_HUMAN, Q9H1C0
    Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004930G-protein coupled receptor activity IEA--
         
    Find genes that share ontologies with LPAR5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for LPAR5:
     Decreased POU5F1-GFP protein e  Decreased melanin production  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lpar5):
     behavior/neurological  integument  nervous system 

    Find genes that share phenotypes with LPAR5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lpar5tm1Jch for LPAR5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LPAR5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LPAR5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LPAR5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LPAR5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat LPAR5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate LPAR5:
    hsa-miR-365 hsa-miR-224 hsa-miR-525-5p hsa-miR-3185 hsa-miR-520g hsa-miR-520a-5p hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidLPAR5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LPAR5
    Predesigned siRNA for gene silencing in human, mouse, rat LPAR5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LPAR5

    Clone
    Products:
         
    OriGene clones in human, mouse for LPAR5 (see all 12)
    OriGene ORF clones in mouse, rat for LPAR5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LPAR5 (NM_020400)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPAR5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPAR5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LPAR5
    Browse ESI BIO Cell Lines and PureStem Progenitors for LPAR5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LPAR5_HUMAN, Q9H1C0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LPAR5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LPAR5 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Ras signaling pathway
    Rap1 signaling pathway0.36
    5PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway


    Find genes that share SuperPaths with LPAR5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for LPAR5
        GPCRs, Class A Rhodopsin-like

    3 Reactome Pathways for LPAR5
        G alpha (q) signalling events
    Lysosphingolipid and LPA receptors
    G alpha (i) signalling events


    2 Kegg Pathways  (Kegg details for LPAR5):
        Rap1 signaling pathway
    PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including LPAR5: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LPAR5

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008150biological_process ND--

    Find genes that share ontologies with LPAR5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LPAR5

    10 HMDB Compounds for LPAR5    About this table
    CompoundSynonyms CAS #PubMed Ids
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----
    LPA(P-16:0e/0:0)1-(1Z-hexadecenyl)-sn-glycero-3-phosphate;LysoPA(dm16:0e) ----

    4 IUPHAR Ligands for LPAR5 (LPA5 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    LPA
    AgonistAgonist5.4 - 7.9223396314 20056548
    farnesyl diphosphate
    AgonistAgonist7.419366702
    farnesyl monophosphate
    AgonistAgonist7.3119366702
    AM966
    AntagonistAntagonist5.120649573



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LPAR5 gene (2 alternative transcripts): 
    NM_001142961.1  NM_020400.5  

    Unigene Cluster for LPAR5:

    Lysophosphatidic acid receptor 5
    Hs.155538  [show with all ESTs]
    Unigene Representative Sequence: BC072394
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329858(uc001qps.2) ENST00000540335 ENST00000431922(uc009zer.2 uc010sff.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LPAR5 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate LPAR5:
    hsa-miR-365 hsa-miR-224 hsa-miR-525-5p hsa-miR-3185 hsa-miR-520g hsa-miR-520a-5p hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidLPAR5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LPAR5
    Predesigned siRNA for gene silencing in human, mouse, rat LPAR5
    Clone
    Products:
         
    OriGene clones in human, mouse for LPAR5 (see all 12)
    OriGene ORF clones in mouse, rat for LPAR5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LPAR5 (NM_020400)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPAR5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPAR5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LPAR5
    OriGene qSTAR qPCR primer pairs in human, mouse for LPAR5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LPAR5
      QuantiTect SYBR Green Assays in human, mouse, rat LPAR5
      QuantiFast Probe-based Assays in human, mouse, rat LPAR5

    Additional mRNA sequence: 

    AB041943.1 AJ272207.1 AK313127.1 BC033571.2 BC072394.1 

    4 DOTS entries:

    DT.431181  DT.121122091  DT.91755582  DT.100758350 

    Selected AceView cDNA sequences (see all 139):

    BI830145 BI828365 BI829306 BI825892 AA769338 BI828527 BI520136 BI520382 
    AF085884 BI520377 BC072394 AI024421 AJ272207 BI826973 BI829508 BM553134 
    BC033010 BI832341 BM553910 BI829134 BI828510 BM560468 BI829361 BI830306 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LPAR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAACTTCT
    LPAR5 Expression
    About this image

    LPAR5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LPAR5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.155538

    UniProtKB/Swiss-Prot: LPAR5_HUMAN, Q9H1C0
    Tissue specificity: Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus

        Pathway & Disease-focused RT2 Profiler PCR Array including LPAR5: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LPAR5
    OriGene qSTAR qPCR primer pairs in human, mouse for LPAR5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LPAR5
    QuantiTect SYBR Green Assays in human, mouse, rat LPAR5
    QuantiFast Probe-based Assays in human, mouse, rat LPAR5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for LPAR5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lpar51 , 5 lysophosphatidic acid receptor 51, 5 80.78(n)1
    81.42(a)1
      6 (59.21 cM)5
    3818101  NM_001163268.11  NP_001156740.11 
     1250679205 
    chicken
    (Gallus gallus)
    Aves LPAR51 lysophosphatidic acid receptor 5 57.56(n)
    53.49(a)
      418279  XM_416504.4  XP_416504.2 
    lizard
    (Anolis carolinensis)
    Reptilia LPAR56
    lysophosphatidic acid receptor 5
    53(a)
    1 ↔ 1
    GL343381.1(799511-800878)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lpar51 lysophosphatidic acid receptor 5 56.55(n)
    51.16(a)
      100216171  XM_002941916.2  XP_002941962.2 
    zebrafish
    (Danio rerio)
    Actinopterygii lpar5a6
    lysophosphatidic acid receptor 5a
    33(a)
    many ↔ many
    2(48396762-48398332) ENSDARG00000010384


    ENSEMBL Gene Tree for LPAR5 (if available)
    TreeFam Gene Tree for LPAR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LPAR5 gene
    OXGR12  P2RY42  GPR172  P2RY12  P2RY62  GPR1742  LPAR62  CYSLTR12  
    GPR1832  LPAR42  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    15 SIMAP similar genes for LPAR5 using alignment to 1 protein entry:     LPAR5_HUMAN:
    KPG_010    LPAR6    LPAR4    CXCR2    IL8RB    CXCR1
    GPR17    GPR55    SSTR4    GPR68    CYSLTR2    GPR183
    KPG_011    KPG_007    NPBWR1

    Find genes that share paralogs with LPAR5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LPAR5 (see all 387)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1383926771,2
    --6727547(+) TTAGCC/TGGGTG 2 -- ds50010--------
    rs1906227261,2
    --6727603(+) GGAGAA/GTCCTA 2 -- ds50010--------
    rs1424645291,2
    --6727677(+) CAGTGC/TGAGAC 2 -- ds50010--------
    rs1835389891,2
    --6727727(+) AGGTGC/GCCCAT 2 -- ds50010--------
    rs1864690101,2
    --6727728(+) GGTGGC/TCCATT 2 -- ds50010--------
    rs110642891,2
    C,F,H--6727749(+) CCAGCG/ATGCTG 2 -- ds500119Minor allele frequency- A:0.24NS EA NA WA CSA 2056
    rs1463381511,2
    --6727791(+) TCACTA/CTTAAC 2 -- ds50010--------
    rs1483027501,2
    --6727797(+) TTAACC/TTCCCC 2 -- ds50010--------
    rs732648561,2
    C,F--6727896(+) CCACCC/TCCCAG 2 -- ds50013Minor allele frequency- T:0.19WA 122
    rs1415606161,2
    --6727935(+) CTGATA/GTGCCC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for LPAR5 (6728001 - 6745613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LPAR5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509452CNV Insertion20534489
    nsv832322CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LPAR5
    DNA2.0 Custom Variant and Variant Library Synthesis for LPAR5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606926    OMIM disorders: --


    Find genes that share disorders with LPAR5           About GenesLikeMe

    Genetic Association Database (GAD): LPAR5

    Export disorders for LPAR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LPAR5 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with LPAR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)1, 2, 3 Lee D.K.... O'Dowd B.F. (Gene 2001)
    2. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. (PubMed id 11062477)1, 2, 3 White K.E.... Strom T.M. (Nat. Genet. 2000)
    3. Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. (PubMed id 16651401)1, 3 Kotarsky K....Olde B. (J. Pharmacol. Exp. Ther. 2006)
    4. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. (PubMed id 16774927)1, 3 Lee C.W....Chun J. (J. Biol. Chem. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    7. LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1I^ release. (PubMed id 21464938)1 Lundequist A. and Boyce J.A. (PLoS ONE 2011)
    8. Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells. (PubMed id 21832242)1 Yoo B.K....Yun C.C. (Am. J. Physiol., Cell Physiol. 2011)
    9. LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4. (PubMed id 20069565)1 Liu Y.B....Billiard J. (J. Cell. Biochem. 2010)
    10. Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression. (PubMed id 19860625)1 Kumar S.A....Gibson S.B. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57121 HGNC: 13307 AceView: GPR92andACRBP Ensembl:ENSG00000184574 euGenes: HUgn57121
    ECgene: LPAR5 Kegg: 57121 H-InvDB: LPAR5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LPAR5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LPAR5 gene:
    Search GeneIP for patents involving LPAR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of LPAR5
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for LPAR5 (LPAR5/LPA5/GPR92)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LPAR5   OriGene RNAi products in human, mouse, rat for LPAR5  
     OriGene qPCR primer pairs and template standards for LPAR5   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LPAR5  
     OriGene qSTAR qPCR primer pairs in human, mouse for LPAR5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LPAR5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LPAR5   OriGene Custom Protein Services for LPAR5  

     
     
     Block miRNA regulation of human, mouse, rat LPAR5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LPAR5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LPAR5 Predesigned siRNA for gene silencing in human, mouse, rat LPAR5
     QuantiFast Probe-based Assays in human, mouse, rat LPAR5 QuantiTect SYBR Green Assays in human, mouse, rat LPAR5
     PCR Arrays including human, mouse, rat LPAR5 Search Chromatin IP Primers for LPAR5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LPAR5  Search GeneGlobe Interaction Network for LPAR5
     Regulatory tfbs in LPAR5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LPAR5 GenScript cDNA clones with any tag delivered in your preferred vector for LPAR5
     GenScript Custom Assay Services for LPAR5 GenScript Custom overexpressing Cell Line Services for LPAR5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for LPAR5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LPAR5 antibodies
     LPAR5 proteins
     Search for Antibodies for LPAR5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for LPAR5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LPAR5
     Antibodies for LPAR5
     ELISAs for LPAR5
     CLIAs for LPAR5



     Browse ESI BIO Cell Lines and PureStem Progenitors for LPAR5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR5
     SwitchGear 3'UTR luciferase reporter plasmids for LPAR5
     SwitchGear Promoter luciferase reporter plasmids for LPAR5
     ThermoFisher Antibodies for LPAR5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPAR5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LPAR5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LPAR5
     LSBio Antibodies in human, mouse, rat for LPAR5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for LPAR5
      Search eBioscience for proteins for LPAR5
      Search eBioscience for elisas for LPAR5
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LPAR5 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4