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Aliases for LPAR4 Gene

Aliases for LPAR4 Gene

  • Lysophosphatidic Acid Receptor 4 2 3 5
  • G Protein-Coupled Receptor 23 2 3
  • G-Protein Coupled Receptor 23 3 4
  • Purinergic Receptor 9 3 4
  • P2Y Purinoceptor 9 3 4
  • P2Y5-Like Receptor 3 4
  • LPA Receptor 4 3 4
  • GPR23 3 4
  • LPA-4 3 4
  • P2RY9 3 4
  • LPA4 3 4
  • P2Y9 3 4
  • P2Y5-LIKE 3

External Ids for LPAR4 Gene

Previous HGNC Symbols for LPAR4 Gene

  • GPR23

Previous GeneCards Identifiers for LPAR4 Gene

  • GC0XP077896
  • GC0XP078004
  • GC0XP071584

Summaries for LPAR4 Gene

Entrez Gene Summary for LPAR4 Gene

  • This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]

GeneCards Summary for LPAR4 Gene

LPAR4 (Lysophosphatidic Acid Receptor 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Pathways in cancer. GO annotations related to this gene include G-protein coupled receptor activity and lipid binding. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for LPAR4 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.

Gene Wiki entry for LPAR4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR4 Gene

Genomics for LPAR4 Gene

Regulatory Elements for LPAR4 Gene

Enhancers for LPAR4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LPAR4 on UCSC Golden Path with GeneCards custom track

Promoters for LPAR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LPAR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPAR4 Gene

Chromosome:
X
Start:
78,747,709 bp from pter
End:
78,757,754 bp from pter
Size:
10,046 bases
Orientation:
Plus strand

Genomic View for LPAR4 Gene

Genes around LPAR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR4 Gene

Proteins for LPAR4 Gene

  • Protein details for LPAR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99677-LPAR4_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 4
    Protein Accession:
    Q99677
    Secondary Accessions:
    • B2RAC7
    • O15132
    • Q502U9
    • Q6NSP5

    Protein attributes for LPAR4 Gene

    Size:
    370 amino acids
    Molecular mass:
    41895 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAR4 Gene

Proteomics data for LPAR4 Gene at MOPED

Post-translational modifications for LPAR4 Gene

  • Glycosylation at Asn 15, Asn 24, Asn 28, and Asn 183
  • Modification sites at PhosphoSitePlus

Other Protein References for LPAR4 Gene

No data available for DME Specific Peptides for LPAR4 Gene

Domains & Families for LPAR4 Gene

Gene Families for LPAR4 Gene

Protein Domains for LPAR4 Gene

Suggested Antigen Peptide Sequences for LPAR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99677

UniProtKB/Swiss-Prot:

LPAR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR4: view

Function for LPAR4 Gene

Molecular function for LPAR4 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.

Gene Ontology (GO) - Molecular Function for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0070915 lysophosphatidic acid receptor activity IEA --
genes like me logo Genes that share ontologies with LPAR4: view
genes like me logo Genes that share phenotypes with LPAR4: view

Animal Models for LPAR4 Gene

MGI Knock Outs for LPAR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for LPAR4

CRISPR Products

miRNA for LPAR4 Gene

miRTarBase miRNAs that target LPAR4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPAR4 Gene

Localization for LPAR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPAR4 Gene COMPARTMENTS Subcellular localization image for LPAR4 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for LPAR4 Gene

Pathways & Interactions for LPAR4 Gene

genes like me logo Genes that share pathways with LPAR4: view

Interacting Proteins for LPAR4 Gene

Selected Interacting proteins: Q99677-LPAR4_HUMAN for LPAR4 Gene via I2D

Symbol External ID(s) Details
BCL6

Gene Ontology (GO) - Biological Process for LPAR4 Gene

None

No data available for SIGNOR curated interactions for LPAR4 Gene

Drugs & Compounds for LPAR4 Gene

(8) Drugs for LPAR4 Gene - From: ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Antagonist 0
MC-1 Investigational Pharma 0
AM966 Pharma Antagonist 0
farnesyl monophosphate Pharma Antagonist 0
LPA Pharma Agonist 0

(15) Additional Compounds for LPAR4 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate

(5) Tocris Compounds for LPAR4 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Endogenous agonist of LPA1 and LPA2 325465-93-8
GRI 977143 Selective LPA2 receptor non-lipid agonist 325850-81-5
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(1) ApexBio Compounds for LPAR4 Gene

Compound Action Cas Number
Ki16425 LPA receptor antagonist 355025-24-0
genes like me logo Genes that share compounds with LPAR4: view

Transcripts for LPAR4 Gene

Unigene Clusters for LPAR4 Gene

Lysophosphatidic acid receptor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR4 Gene

No ASD Table

Relevant External Links for LPAR4 Gene

GeneLoc Exon Structure for
LPAR4
ECgene alternative splicing isoforms for
LPAR4

Expression for LPAR4 Gene

mRNA expression in normal human tissues for LPAR4 Gene

mRNA differential expression in normal tissues according to GTEx for LPAR4 Gene

This gene is overexpressed in Ovary (x4.8).

SOURCE GeneReport for Unigene cluster for LPAR4 Gene Hs.522701

mRNA Expression by UniProt/SwissProt for LPAR4 Gene

Q99677-LPAR4_HUMAN
Tissue specificity: High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.
genes like me logo Genes that share expression patterns with LPAR4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for LPAR4 Gene

Orthologs for LPAR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LPAR4 35
  • 92.79 (n)
  • 97.3 (a)
LPAR4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPAR4 35
  • 93.6 (n)
  • 97.3 (a)
LPAR4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpar4 35
  • 90.63 (n)
  • 98.38 (a)
Lpar4 16
Lpar4 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LPAR4 35
  • 99.82 (n)
  • 99.73 (a)
LPAR4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpar4 35
  • 90.36 (n)
  • 98.38 (a)
oppossum
(Monodelphis domestica)
Mammalia LPAR4 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPAR4 35
  • 75.29 (n)
  • 84.77 (a)
LPAR4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPAR4 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar4 35
  • 74.26 (n)
  • 79.83 (a)
Str.9558 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25260 35
zebrafish
(Danio rerio)
Actinopterygii LOC794698 35
  • 65.69 (n)
  • 66.96 (a)
zgc:172079 36
  • 30 (a)
ManyToMany
Species with no ortholog for LPAR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR4 Gene

ENSEMBL:
Gene Tree for LPAR4 (if available)
TreeFam:
Gene Tree for LPAR4 (if available)

Paralogs for LPAR4 Gene

genes like me logo Genes that share paralogs with LPAR4: view

Variants for LPAR4 Gene

Sequence variations from dbSNP and Humsavar for LPAR4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747746220 -- 78,755,971(+) TAGAA(C/T)CCACC reference, missense
rs747778922 -- 78,756,718(+) AAACA(A/G)GAAAG downstream-variant-500B, utr-variant-3-prime
rs747844858 -- 78,757,660(+) CAGGA(A/G)CAGTG utr-variant-3-prime
rs747969278 -- 78,754,884(+) AGAAG(A/T)TTCAT reference, missense
rs748031289 -- 78,747,194(+) TAAGT(A/G)AGTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LPAR4 Gene

Variant ID Type Subtype PubMed ID
dgv517n21 CNV Gain 19592680

Variation tolerance for LPAR4 Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPAR4 Gene

HapMap Linkage Disequilibrium report
LPAR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR4 Gene

Disorders for LPAR4 Gene

Relevant External Links for LPAR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPAR4

No disorders were found for LPAR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPAR4 Gene

Publications for LPAR4 Gene

  1. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. (PMID: 9223435) Janssens R. … Communi D. (Biochem. Biophys. Res. Commun. 1997) 3 4 23 67
  2. Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells. (PMID: 25849892) Ishii S. … Tsujiuchi T. (Biochem. Biophys. Res. Commun. 2015) 3
  3. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. (PMID: 24602016) Kihara Y. … Chun J. (Br. J. Pharmacol. 2014) 3
  4. Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells. (PMID: 23467751) Matayoshi S. … Kato S. (Int. J. Oncol. 2013) 3
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for LPAR4 Gene

Sources for LPAR4 Gene

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