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Aliases for LPAR4 Gene

Aliases for LPAR4 Gene

  • Lysophosphatidic Acid Receptor 4 2 3
  • GPR23 3 4 6
  • P2RY9 3 4 6
  • LPA4 3 4 6
  • P2Y9 3 4 6
  • G Protein-Coupled Receptor 23 2 3
  • G-Protein Coupled Receptor 23 3 4
  • Purinergic Receptor 9 3 4
  • P2Y Purinoceptor 9 3 4
  • P2Y5-Like Receptor 3 4
  • LPA Receptor 4 3 4
  • LPA-4 3 4
  • P2Y5-LIKE 3

External Ids for LPAR4 Gene

Previous Symbols for LPAR4 Gene

  • GPR23

Summaries for LPAR4 Gene

Entrez Gene Summary for LPAR4 Gene

  • This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]

GeneCards Summary for LPAR4 Gene

LPAR4 (Lysophosphatidic Acid Receptor 4) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and lipid binding. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for LPAR4 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.

Gene Wiki entry for LPAR4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR4 Gene

Genomics for LPAR4 Gene

Genomic Location for LPAR4 Gene

Start:
78,747,709 bp from pter
End:
78,758,714 bp from pter
Size:
11,006 bases
Orientation:
Plus strand

Genomic View for LPAR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR4 Gene

Regulatory Elements for LPAR4 Gene

Proteins for LPAR4 Gene

  • Protein details for LPAR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99677-LPAR4_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 4
    Protein Accession:
    Q99677
    Secondary Accessions:
    • B2RAC7
    • O15132
    • Q502U9
    • Q6NSP5

    Protein attributes for LPAR4 Gene

    Size:
    370 amino acids
    Molecular mass:
    41895 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAR4 Gene

Proteomics data for LPAR4 Gene at MOPED

Post-translational modifications for LPAR4 Gene

  • Glycosylation at Asn15, Asn24, Asn28, and Asn183

Other Protein References for LPAR4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LPAR4 Gene

Domains for LPAR4 Gene

Gene Families for LPAR4 Gene

HGNC:
  • LPAR :GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid
IUPHAR :

Protein Domains for LPAR4 Gene

UniProtKB/Swiss-Prot:

LPAR4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q99677
genes like me logo Genes that share domains with LPAR4: view

Function for LPAR4 Gene

Molecular function for LPAR4 Gene

UniProtKB/Swiss-Prot Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.

Gene Ontology (GO) - Molecular Function for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with LPAR4: view
genes like me logo Genes that share phenotypes with LPAR4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LPAR4 Gene

Localization for LPAR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPAR4 Gene COMPARTMENTS Subcellular localization image for LPAR4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9073069
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with LPAR4: view

Pathways for LPAR4 Gene

genes like me logo Genes that share pathways with LPAR4: view

Interacting Proteins for LPAR4 Gene

Selected Interacting proteins: Q99677-LPAR4_HUMAN for LPAR4 Gene via I2D

Symbol External ID(s) Details
BCL6

Gene Ontology (GO) - Biological Process for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with LPAR4: view

Compounds for LPAR4 Gene

(11) HMDB Compounds for LPAR4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
LPA(0:0/16:0)
  • Lysophosphatidic acid(16:0)
Not Available
LPA(0:0/18:0)
  • 2-octadecanoyl-phosphatidic acid
Not Available
LPA(0:0/18:1(9Z))
  • LPA(18:1)
Not Available
LPA(0:0/18:2(9Z,12Z))
  • LPA(0:0/18:2n6)
Not Available

(4) IUPHAR Ligand for LPAR4 Gene

Ligand Type Action Affinity Pubmed IDs
farnesyl diphosphate Antagonist Antagonist 6.81
farnesyl monophosphate Antagonist Antagonist 6.3
AM966 Antagonist Antagonist 5.7
LPA Agonist Agonist 5.6
genes like me logo Genes that share compounds with LPAR4: view

Transcripts for LPAR4 Gene

Unigene Clusters for LPAR4 Gene

Lysophosphatidic acid receptor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR4 Gene

No ASD Table

Relevant External Links for LPAR4 Gene

GeneLoc Exon Structure for
LPAR4
ECgene alternative splicing isoforms for
LPAR4

Expression for LPAR4 Gene

mRNA expression in normal human tissues for LPAR4 Gene

mRNA differential expression in normal tissues according to GTEx for LPAR4 Gene

This gene is overexpressed in Ovary (4.8).

SOURCE GeneReport for Unigene cluster for LPAR4 Gene Hs.522701

mRNA Expression by UniProt/SwissProt for LPAR4 Gene

Q99677-LPAR4_HUMAN
Tissue specificity: High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.
genes like me logo Genes that share expressions with LPAR4: view

Orthologs for LPAR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPAR4 36
  • 99.82 (n)
  • 99.73 (a)
LPAR4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPAR4 36
  • 92.79 (n)
  • 97.3 (a)
LPAR4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPAR4 36
  • 93.6 (n)
  • 97.3 (a)
LPAR4 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpar4 36
  • 90.63 (n)
  • 98.38 (a)
Lpar4 16
Lpar4 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPAR4 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpar4 36
  • 90.36 (n)
  • 98.38 (a)
chicken
(Gallus gallus)
Aves LPAR4 36
  • 75.29 (n)
  • 84.77 (a)
LPAR4 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPAR4 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25260 36
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar4 36
  • 74.26 (n)
  • 79.83 (a)
Str.9558 36
zebrafish
(Danio rerio)
Actinopterygii LOC794698 36
  • 65.69 (n)
  • 66.96 (a)
zgc:172079 37
  • 30 (a)
ManyToMany
Species with no ortholog for LPAR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR4 Gene

ENSEMBL:
Gene Tree for LPAR4 (if available)
TreeFam:
Gene Tree for LPAR4 (if available)

Paralogs for LPAR4 Gene

genes like me logo Genes that share paralogs with LPAR4: view

Variants for LPAR4 Gene

Sequence variations from dbSNP and Humsavar for LPAR4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1140040 -- 78,756,240(+) GTGGC(C/T)AGTGG utr-variant-3-prime
rs1140041 -- 78,756,405(+) TTTTG(A/G)ACTGT downstream-variant-500B, utr-variant-3-prime
rs1140042 -- 78,756,912(+) AATAC(A/T)AAAAA utr-variant-3-prime
rs1140043 -- 78,756,931(+) ATAAA(C/G)CAAAA utr-variant-3-prime
rs1140044 -- 78,756,933(+) AAAGC(A/C)AAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LPAR4 Gene

Variant ID Type Subtype PubMed ID
dgv517n21 CNV Gain 19592680

Relevant External Links for LPAR4 Gene

HapMap Linkage Disequilibrium report
LPAR4
Locus Specific Mutation Databases (LSDB)
LPAR4

Disorders for LPAR4 Gene

No disorders were found for LPAR4 Gene.

No data available for UniProtKB/Swiss-Prot for LPAR4 Gene

Publications for LPAR4 Gene

  1. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. (PMID: 9223435) Janssens R. … Communi D. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  2. Cloning and chromosomal mapping of four putative novel human G- protein-coupled receptor genes. (PMID: 9073069) O'Dowd B.F. … George S.R. (Gene 1997) 3 4
  3. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. (PMID: 12724320) Noguchi K. … Shimizu T. (J. Biol. Chem. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for LPAR4 Gene

Sources for LPAR4 Gene

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