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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LPAR4 Gene

protein-coding   GIFtS: 54
GCID: GC0XP078004

Lysophosphatidic Acid Receptor 4

(Previous name: G protein-coupled receptor 23)
(Previous symbol: GPR23)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysophosphatidic Acid Receptor 41 2     LPA-42 3
GPR231 2 3 5     G-Protein Coupled Receptor 232 3
LPA42 3 5     LPA Receptor 42 3
P2RY92 3 5     P2Y Purinoceptor 92 3
P2Y92 3 5     P2Y5-Like Receptor2 3
G Protein-Coupled Receptor 231 2     P2Y5-LIKE2
Purinergic Receptor 92 3     

External Ids:    HGNC: 44781   Entrez Gene: 28462   Ensembl: ENSG000001471457   OMIM: 3000865   UniProtKB: Q996773   

Export aliases for LPAR4 gene to outside databases

Previous GC identifers: GC0XP077896 GC0XP071584


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LPAR4 Gene:
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y
receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The
encoded protein may play a role in monocytic differentiation. (provided by RefSeq, Feb 2009)

GeneCards Summary for LPAR4 Gene: 
LPAR4 (lysophosphatidic acid receptor 4) is a protein-coding gene. Diseases associated with LPAR4 include chronic lymphocytic leukemia, and colon cancer, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Nucleotide-like (purinergic) receptors. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity and G-protein coupled receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot: LPAR4_HUMAN, Q99677
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal
by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of
potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- >
1-alkenyl-LPA

Gene Wiki entry for LPAR4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LPAR4 gene promoter:
         RFX1   HSF1 (long)   Cdc5   AREB6   Sox9   Chx10   HSF1short   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPAR4 promoter sequence
   Search SABiosciences Chromatin IP Primers for LPAR4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPAR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21.1

LPAR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP078004:  view genomic region     (about GC identifiers)

Start:
78,003,206 bp from pter      End:
78,012,591 bp from pter
Size:
9,386 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LPAR4_HUMAN, Q99677 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 4  
Size: 370 amino acids; 41895 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2RAC7 O15132 Q502U9 Q6NSP5

Explore the universe of human proteins at neXtProt for LPAR4: NX_Q99677

Explore proteomics data for LPAR4 at MOPED 

LPAR4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

LPAR4 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001264929.1  NP_005287.1  

ENSEMBL proteins: 
 ENSP00000362398   ENSP00000408205  
Reactome Protein details: Q99677
Human Recombinant Protein Products for LPAR4: 
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Cloud-Clone Corp. Proteins for LPAR4 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane TAS9073069
GO:0016021integral to membrane ----

LPAR4 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LPAR: GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid

IUPHAR Guide to PHARMACOLOGY protein family classification: LPA4 receptor 
Lysophospholipid (LPA) receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR002188 P2Y5_purnocptor
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q99677

ProtoNet protein and cluster: Q99677

1 Blocks protein domain: IPB002188 P2Y5 purinoceptor signature

UniProtKB/Swiss-Prot: LPAR4_HUMAN, Q99677
Similarity: Belongs to the G-protein coupled receptor 1 family


LPAR4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: LPAR4_HUMAN, Q99677
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal
by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of
potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- >
1-alkenyl-LPA

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0008289lipid binding IEA--
GO:0045028G-protein coupled purinergic nucleotide receptor activity ----
     
LPAR4 for ontologies           About GeneDecksing


Phenotypes:
     11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lpar4):
 cardiovascular system  craniofacial  embryogenesis  growth/size  homeostasis/metabolism 
 immune system  integument  mortality/aging  muscle  respiratory system 
 skeleton 

LPAR4 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for LPAR4 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LPAR4 
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miRNA
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SwitchGear 3'UTR luciferase reporter plasmidLPAR4 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for LPAR4 About   (see all 7)                                                                                              See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
GPCRs, Class A Rhodopsin-like0.41
GPCR ligand binding0.71
Neuroactive ligand-receptor interaction0.37
2Nucleotide-like (purinergic) receptors
Nucleotide-like (purinergic) receptors0.75
Nucleotide GPCRs0.59
P2Y receptors0.75
3Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
4G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
5Adenylate cyclase activating pathway
LPA4-mediated signaling events0.67

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4 BioSystems Pathways for LPAR4
    GPCRs, Class A Rhodopsin-like
LPA receptor mediated events
LPA4-mediated signaling events
Nucleotide GPCRs

5/9        Reactome Pathways for LPAR4 (see all 9)
    GPCR downstream signaling
P2Y receptors
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by GPCR
GPCR ligand binding


2         Kegg Pathways  (Kegg details for LPAR4):
    Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway


LPAR4 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LPAR4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/127 Interacting proteins for LPAR4 (Q996773 ENSP000003623984) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
InteractantInteraction Details
GeneCardExternal ID(s)
BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
ADRBK1ENSP000003122624STRING: ENSP00000312262
AVPR1AENSP000002991784STRING: ENSP00000299178
CYSLTR1ENSP000003624014STRING: ENSP00000362401
CYSLTR2ENSP000002820184STRING: ENSP00000282018
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway TAS9073069

LPAR4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LPAR4

10/11 HMDB Compounds for LPAR4 (see all 11)    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--
LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----

4 IUPHAR Ligands for LPAR4 (LPA4 receptor)    About this table 
LigandTypeActionAffinityPubmed IDs
LPA
AgonistAgonist7.3512724320
farnesyl monophosphate
AntagonistAntagonist5.8419366702
farnesyl diphosphate
AntagonistAntagonist5.719366702
AM966
AntagonistAntagonist5.120649573

Search CenterWatch for drugs/clinical trials and news about LPAR4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LPAR4 gene (2 alternative transcripts): 
NM_001278000.1  NM_005296.2  

Unigene Cluster for LPAR4:

Lysophosphatidic acid receptor 4
Hs.522701  [show with all ESTs]
Unigene Representative Sequence: NM_005296
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000373301(uc022bzj.1) ENST00000435339(uc010nme.3)
miRNA
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8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate LPAR4 (see all 14):
hsa-miR-4291 hsa-miR-607 hsa-miR-222* hsa-miR-631 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-3074-3p
SwitchGear 3'UTR luciferase reporter plasmidLPAR4 3' UTR sequence
Inhib. RNA
Products:
     
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LPAR4

Additional mRNA sequence: 

AK314134.1 BC069996.1 BC074722.2 BC095538.1 U90322.1 

9 DOTS entries:

DT.211100  DT.121281364  DT.303092  DT.101959737  DT.121281363  DT.121281365  DT.40229716  DT.99978295 
DT.91748079 

23 AceView cDNA sequences:

BC069996 F03833 BM697590 BU735774 F07588 AA424904 BC074722 AA424772 
BX092792 AA779879 NM_005296 AA780191 AU129897 BM973092 AU126429 U90322 
CN841728 CK130269 H20663 W06952 AU151963 CN841903 H20571 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LPAR4 expression in normal human tissues (normalized intensities)      LPAR4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCAAACTTCA
LPAR4 Expression
About this image


LPAR4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/9 selected tissues (see all 9) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 7 entries
         HyStem+TGFbeta3+GDF5-induced SK11 cells
         skeleton/pectoral girdle and thoracic body wall/sternum   
 
 Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
         HyStem+TGFbeta3+GDF5-induced SK11 cells
 
 Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
         Midgut
 
 Heart (Cardiovascular System)
         heart/ventricle   
 
 Liver (Hepatobiliary System)
         Mesothelial Cells Hepatic Mesenchyme

See LPAR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LPAR4

SOURCE GeneReport for Unigene cluster: Hs.522701

UniProtKB/Swiss-Prot: LPAR4_HUMAN, Q99677
Tissue specificity: High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate,
frontal cortex, pons, hypothalamus and hippocampus

    SABiosciences Expression via Pathway-Focused PCR Array including LPAR4: 
          G Protein Coupled Receptors 384HT in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for LPAR4
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LPAR4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LPAR4 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lpar41 , 5 lysophosphatidic acid receptor 41, 5 90.63(n)1
98.38(a)1
  X (47.39 cM)5
781341  NM_175271.41  NP_780480.21 
 1069206255 
chicken
(Gallus gallus)
Aves LPAR41 lysophosphatidic acid receptor 4 75.29(n)
84.77(a)
  422149  XM_420150.3  XP_420150.1 
lizard
(Anolis carolinensis)
Reptilia LPAR46
Uncharacterized protein
82(a)
1 ↔ 1
GL343528.1(280997-282052)
African clawed frog
(Xenopus laevis)
Amphibia Xl.252602 Xenopus laevis transcribed sequence with moderate similarity more 76.46(n)    48052236 
zebrafish
(Danio rerio)
Actinopterygii LOC7946981 lysophosphatidic acid receptor 4-like 65.69(n)
66.96(a)
  794698  XM_001334677.1  XP_001334713.1 


ENSEMBL Gene Tree for LPAR4 (if available)
TreeFam Gene Tree for LPAR4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for LPAR4 gene
P2RY42  CYSLTR12  CYSLTR22  P2RY22  PTAFR2  OXGR12  P2RY112  P2RY12  
GPR172  P2RY62  GPR1742  LPAR62  LPAR52  GPR1832  P2RY102  SUCNR12  
18/46 SIMAP similar genes for LPAR4 using alignment to 1 protein entry:     LPAR4_HUMAN(see all similar genes):
LPAR6    P2RY5    P2RY10    CCR4    KPG_010    LPAR5
GPR17    P2RY8    CYSLTR2    F2RL1    GPR35    KPG_007
KPG_011    AGTR1    CXCR1    P2RY4    AGTR2    CCR8

LPAR4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/187 SNPs in LPAR4 are shown (see all 187)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1887094901,2
--77973061(+) GCATTA/GAGTTG 2 -- us2k10--------
rs734938521,2
C,F--77973106(+) CTTACC/TCTTAT 2 -- us2k11Minor allele frequency- T:0.50WA 2
rs1499533541,2
C--77973146(+) CCTACC/TCTCAC 2 -- us2k10--------
rs1500077141,2
C--77973238(+) ATCAT-/CCAACCAA 2 -- us2k10--------
rs59027721,2
C--77973367(+) TTTTT-/T/TT  
        
CAAAA
2 -- us2k1 trp30--------
rs1815521061,2
--77973481(+) TGCACC/TGAGTA 2 -- us2k10--------
rs39234241,2
C,F--77973580(-) TCCCCC/TCTCTG 2 -- us2k1 trp33Minor allele frequency- T:0.33NA WA 6
rs1446885861,2
C--77973652(+) TTAGAC/GCCAGT 2 -- us2k10--------
rs1858852551,2
--77973831(+) GAGGAA/TCCTCC 2 -- us2k10--------
rs1904845791,2
--77973967(+) AGAAGC/GCTTGC 2 -- us2k10--------

HapMap Linkage Disequilibrium report for LPAR4 (78003206 - 78012591 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for LPAR4:    About this table     
Variant IDTypeSubtypePubMed ID
dgv517n21CNV Gain19592680


Locus Specific Mutation Databases (LSDB): LPAR4
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 300086    OMIM disorders: --

3 diseases for LPAR4:    About MalaCards
chronic lymphocytic leukemia    colon cancer    leukemia


LPAR4 for disorders           About GeneDecksing


Export disorders for LPAR4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for LPAR4 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with LPAR4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. (PubMed id 9223435)1, 2, 9 Janssens R.... Communi D. (1997)
  2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
  3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. (PubMed id 12724320)1, 2 Noguchi K.... Shimizu T. (2003)
  6. Cloning and chromosomal mapping of four putative novel human G- protein-coupled receptor genes. (PubMed id 9073069)1, 2 O'Dowd B.F.... George S.R. (1997)
  7. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
  8. LPA induces osteoblast differentiation through interp lay of two receptors: LPA1 and LPA4. (PubMed id 20069565)1 Liu Y.B....Billiard J. (2010)
  9. Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells. (PubMed id 20890765)1 Tsujino M....Tsujiuchi T. (2010)
  10. Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelia l growth factor expression. (PubMed id 19860625)1 Kumar S.A....Gibson S.B. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
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NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 2846 HGNC: 4478 AceView: GPR23 Ensembl:ENSG00000147145 euGenes: HUgn2846
ECgene: LPAR4 Kegg: 2846 H-InvDB: LPAR4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for LPAR4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for LPAR4 gene:
Search GeneIP for patents involving LPAR4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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