Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LPAR4 Gene

Aliases for LPAR4 Gene

  • Lysophosphatidic Acid Receptor 4 2 3 5
  • G-Protein Coupled Receptor 23 3 4
  • Purinergic Receptor 9 3 4
  • P2Y Purinoceptor 9 3 4
  • P2Y5-Like Receptor 3 4
  • LPA Receptor 4 3 4
  • GPR23 3 4
  • LPA-4 3 4
  • P2RY9 3 4
  • LPA4 3 4
  • P2Y9 3 4
  • G Protein-Coupled Receptor 23 2
  • P2Y5-LIKE 3

External Ids for LPAR4 Gene

Previous HGNC Symbols for LPAR4 Gene

  • GPR23

Previous GeneCards Identifiers for LPAR4 Gene

  • GC0XP077896
  • GC0XP078004
  • GC0XP071584

Summaries for LPAR4 Gene

Entrez Gene Summary for LPAR4 Gene

  • This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]

GeneCards Summary for LPAR4 Gene

LPAR4 (Lysophosphatidic Acid Receptor 4) is a Protein Coding gene. Diseases associated with LPAR4 include Differentiated Thyroid Carcinoma. Among its related pathways are Nucleotide-like (purinergic) receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and lipid binding. An important paralog of this gene is LPAR6.

UniProtKB/Swiss-Prot for LPAR4 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.

Gene Wiki entry for LPAR4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR4 Gene

Genomics for LPAR4 Gene

Regulatory Elements for LPAR4 Gene

Enhancers for LPAR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG078768 0.7 ENCODE 17.5 +21.9 21886 2.5 CTCF ZNF654 L3MBTL2 BHLHE40 DMAP1 ZEB2 REST MNT RAD21 RAD51 LPAR4 ITM2A TAF9B GC0XP078764 MIR4328
GH0XG079142 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +403.0 403008 15.5 TBP MXI1 TBL1XR1 MAX YBX1 ZBTB40 RELA ARID3A EGR1 POLR2A ITM2A P2RY10 GPR174 RTL3 LPAR4 GC0XM079072
GH0XG079106 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.1 +360.7 360706 3.8 TBP ZNF146 RELA ARID3A RELB IKZF2 CREM ZNF280D MTA2 NR2F1 ITM2A GPR174 P2RY10 LPAR4 GC0XM079072
GH0XG079159 1.2 Ensembl ENCODE dbSUPER 4 +416.5 416544 9.0 PKNOX1 ZNF146 WRNIP1 ARID3A CBX5 IKZF2 CREM MTA2 CBFB BHLHE40 ITM2A RTL3 LPAR4 GPR174 GC0XM079072
GH0XG078706 0.2 ENCODE 12.3 -41.4 -41411 0.2 LPAR4 PPATP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LPAR4 on UCSC Golden Path with GeneCards custom track

Promoters for LPAR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247361 192 999 HLF

Genomic Location for LPAR4 Gene

Chromosome:
X
Start:
78,747,709 bp from pter
End:
78,757,754 bp from pter
Size:
10,046 bases
Orientation:
Plus strand

Genomic View for LPAR4 Gene

Genes around LPAR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR4 Gene

Proteins for LPAR4 Gene

  • Protein details for LPAR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99677-LPAR4_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 4
    Protein Accession:
    Q99677
    Secondary Accessions:
    • B2RAC7
    • O15132
    • Q502U9
    • Q6NSP5

    Protein attributes for LPAR4 Gene

    Size:
    370 amino acids
    Molecular mass:
    41895 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAR4 Gene

Post-translational modifications for LPAR4 Gene

  • Glycosylation at Asn15, posLast=2424, posLast=2828, and Asn183
  • Modification sites at PhosphoSitePlus

Other Protein References for LPAR4 Gene

No data available for DME Specific Peptides for LPAR4 Gene

Domains & Families for LPAR4 Gene

Gene Families for LPAR4 Gene

Protein Domains for LPAR4 Gene

Suggested Antigen Peptide Sequences for LPAR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99677

UniProtKB/Swiss-Prot:

LPAR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR4: view

Function for LPAR4 Gene

Molecular function for LPAR4 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.

Gene Ontology (GO) - Molecular Function for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008289 lipid binding IEA --
GO:0035727 lysophosphatidic acid binding IEA --
GO:0070915 lysophosphatidic acid receptor activity IBA --
genes like me logo Genes that share ontologies with LPAR4: view
genes like me logo Genes that share phenotypes with LPAR4: view

Animal Models for LPAR4 Gene

MGI Knock Outs for LPAR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for LPAR4

CRISPR Products

miRNA for LPAR4 Gene

miRTarBase miRNAs that target LPAR4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LPAR4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPAR4 Gene

Localization for LPAR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LPAR4 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LPAR4: view

Pathways & Interactions for LPAR4 Gene

genes like me logo Genes that share pathways with LPAR4: view

Interacting Proteins for LPAR4 Gene

Selected Interacting proteins: Q99677-LPAR4_HUMAN for LPAR4 Gene via IID

Symbol External ID(s) Details
BAG3
BCL6

Gene Ontology (GO) - Biological Process for LPAR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0035025 positive regulation of Rho protein signal transduction IBA --
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA --
genes like me logo Genes that share ontologies with LPAR4: view

No data available for SIGNOR curated interactions for LPAR4 Gene

Drugs & Compounds for LPAR4 Gene

(13) Drugs for LPAR4 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
farnesyl diphosphate Experimental Pharma Antagonist 0
MC-1 Investigational Pharma 0
H2L 5765834 Pharma LPA1,3,5 antagonist 0
H2L5186303 Pharma Potent and selective LPA2 receptor antagonist 0
Ki16425 Pharma Antagonist LPA receptor antagonist, LPA1 and LPA3 receptor antagonist 0

(10) Additional Compounds for LPAR4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
LPA(16:0/0:0)
  • 1-Hexadecanoyl-phosphatidic acid
  • 1-Palmitoyl lysophosphatidate
  • 1-Palmitoyl lysophosphatidic acid
  • 1-Palmitoyl-glycero-3-phosphate
  • 1-Palmitoylglycerol 3-phosphate

(4) Tocris Compounds for LPAR4 Gene

Compound Action Cas Number
H2L 5765834 LPA1,3,5 antagonist 420841-84-5
H2L5186303 Potent and selective LPA2 receptor antagonist 139262-76-3
Ki 16425 LPA1 and LPA3 receptor antagonist 355025-24-0
TC LPA5 4 LPA5 receptor antagonist 1393814-38-4

(6) ApexBio Compounds for LPAR4 Gene

Compound Action Cas Number
1-Oleoyl lysophosphatidic acid sodium salt Activates LPA receptor 325465-93-8
H2L 5765834 420841-84-5
H2L5186303 139262-76-3
Ki16198 LPA antagonist 355025-13-7
Ki16425 LPA receptor antagonist 355025-24-0
TC LPA5 4 1393814-38-4
genes like me logo Genes that share compounds with LPAR4: view

Drug Products

Transcripts for LPAR4 Gene

Unigene Clusters for LPAR4 Gene

Lysophosphatidic acid receptor 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LPAR4

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR4 Gene

No ASD Table

Relevant External Links for LPAR4 Gene

GeneLoc Exon Structure for
LPAR4
ECgene alternative splicing isoforms for
LPAR4

Expression for LPAR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LPAR4 Gene

mRNA differential expression in normal tissues according to GTEx for LPAR4 Gene

This gene is overexpressed in Ovary (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of LPAR4 Gene:

LPAR4

SOURCE GeneReport for Unigene cluster for LPAR4 Gene:

Hs.522701

mRNA Expression by UniProt/SwissProt for LPAR4 Gene:

Q99677-LPAR4_HUMAN
Tissue specificity: High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.

Evidence on tissue expression from TISSUES for LPAR4 Gene

  • Nervous system(4.1)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with LPAR4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LPAR4 Gene

Orthologs for LPAR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPAR4 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia LPAR4 34 35
  • 93.6 (n)
cow
(Bos Taurus)
Mammalia LPAR4 34 35
  • 92.79 (n)
mouse
(Mus musculus)
Mammalia Lpar4 34 16 35
  • 90.63 (n)
rat
(Rattus norvegicus)
Mammalia Lpar4 34
  • 90.36 (n)
oppossum
(Monodelphis domestica)
Mammalia LPAR4 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves LPAR4 34 35
  • 75.29 (n)
lizard
(Anolis carolinensis)
Reptilia LPAR4 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar4 34
  • 74.26 (n)
Str.9558 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25260 34
zebrafish
(Danio rerio)
Actinopterygii LOC794698 34
  • 65.69 (n)
zgc:172079 35
  • 30 (a)
ManyToMany
Species where no ortholog for LPAR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR4 Gene

ENSEMBL:
Gene Tree for LPAR4 (if available)
TreeFam:
Gene Tree for LPAR4 (if available)

Paralogs for LPAR4 Gene

Variants for LPAR4 Gene

Sequence variations from dbSNP and Humsavar for LPAR4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000323382 -- 78,750,440(+) AATTC(C/T)AAATG intron-variant
rs1000479881 -- 78,758,735(+) TTGAT(C/G)AATTA downstream-variant-500B
rs1001056642 -- 78,752,902(+) CCCCA(A/T)ATATG intron-variant
rs1001505631 -- 78,752,013(+) AAAAG(-/A)AAAAA intron-variant
rs1001658216 -- 78,746,055(+) CACTT(C/T)TTCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LPAR4 Gene

Variant ID Type Subtype PubMed ID
dgv517n21 CNV gain 19592680

Variation tolerance for LPAR4 Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPAR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPAR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR4 Gene

Disorders for LPAR4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LPAR4 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search LPAR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LPAR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPAR4
genes like me logo Genes that share disorders with LPAR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LPAR4 Gene

Publications for LPAR4 Gene

  1. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. (PMID: 9223435) Janssens R. … Communi D. (Biochem. Biophys. Res. Commun. 1997) 3 4 22 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. (PMID: 12724320) Noguchi K. … Shimizu T. (J. Biol. Chem. 2003) 3 4 64

Products for LPAR4 Gene

  • Addgene plasmids for LPAR4

Sources for LPAR4 Gene

Content
Loading form....