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LPAR4 Gene

protein-coding   GIFtS: 52
GCID: GC0XP078004

Lysophosphatidic Acid Receptor 4

(Previous name: G protein-coupled receptor 23)
(Previous symbol: GPR23)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysophosphatidic Acid Receptor 41 2     LPA-42 3
GPR231 2 3 5     G-Protein Coupled Receptor 232 3
LPA42 3 5     LPA Receptor 42 3
P2RY92 3 5     P2Y Purinoceptor 92 3
P2Y92 3 5     P2Y5-Like Receptor2 3
G Protein-Coupled Receptor 231 2     P2Y5-LIKE2
Purinergic Receptor 92 3     

External Ids:    HGNC: 44781   Entrez Gene: 28462   Ensembl: ENSG000001471457   OMIM: 3000865   UniProtKB: Q996773   

Export aliases for LPAR4 gene to outside databases

Previous GC identifers: GC0XP077896 GC0XP071584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LPAR4 Gene:
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y
receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The
encoded protein may play a role in monocytic differentiation. (provided by RefSeq, Feb 2009)

GeneCards Summary for LPAR4 Gene:
LPAR4 (lysophosphatidic acid receptor 4) is a protein-coding gene. GO annotations related to this gene include lipid binding and G-protein coupled receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: LPAR4_HUMAN, Q99677
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal
by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of
potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- >
1-alkenyl-LPA

Gene Wiki entry for LPAR4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LPAR4 gene promoter:
         RFX1   HSF1 (long)   Cdc5   AREB6   Sox9   Chx10   HSF1short   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPAR4 promoter sequence
   Search Chromatin IP Primers for LPAR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LPAR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21.1

LPAR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP078004:  view genomic region     (about GC identifiers)

Start:
78,003,206 bp from pter      End:
78,012,591 bp from pter
Size:
9,386 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LPAR4_HUMAN, Q99677 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 4  
Size: 370 amino acids; 41895 Da
Secondary accessions: B2RAC7 O15132 Q502U9 Q6NSP5

Explore the universe of human proteins at neXtProt for LPAR4: NX_Q99677

Explore proteomics data for LPAR4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn15, Asn24, Asn28, Asn183

  • See LPAR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001264929.1  NP_005287.1  

    ENSEMBL proteins: 
     ENSP00000408205   ENSP00000476460  
    Reactome Protein details: Q99677

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LPAR: GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid

    IUPHAR Guide to PHARMACOLOGY protein family classification: LPA4 receptor
    Lysophospholipid (LPA) receptors

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q99677

    ProtoNet protein and cluster: Q99677

    1 Blocks protein domain: IPB002188 P2Y5 purinoceptor signature

    UniProtKB/Swiss-Prot: LPAR4_HUMAN, Q99677
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with LPAR4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPAR4_HUMAN, Q99677
    Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal
    by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of
    potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- >
    1-alkenyl-LPA

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0008289lipid binding IEA--
         
    Find genes that share ontologies with LPAR4           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lpar4):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  respiratory system 
     skeleton 

    Find genes that share phenotypes with LPAR4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LPAR4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LPAR4_HUMAN, Q99677: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9073069
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with LPAR4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LPAR4 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    P2Y receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Adenylate cyclase inhibitory pathway
    LPA4-mediated signaling events0.53


    Find genes that share SuperPaths with LPAR4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for LPAR4
        GPCRs, Class A Rhodopsin-like
    LPA receptor mediated events
    LPA4-mediated signaling events
    Nucleotide GPCRs

    2 Reactome Pathways for LPAR4
        P2Y receptors
    G alpha (q) signalling events


    3 Kegg Pathways  (Kegg details for LPAR4):
        Rap1 signaling pathway
    Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including LPAR4: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LPAR4

    1 Interacting protein for LPAR4 (Q996773) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL6P411823I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9073069

    Find genes that share ontologies with LPAR4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for LPAR4

    Selected HMDB Compounds for LPAR4 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----

    4 IUPHAR Ligands for LPAR4 (LPA4 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    LPA
    AgonistAgonist7.3512724320
    farnesyl monophosphate
    AntagonistAntagonist5.8419366702
    farnesyl diphosphate
    AntagonistAntagonist5.719366702
    AM966
    AntagonistAntagonist5.120649573



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LPAR4 gene (2 alternative transcripts): 
    NM_001278000.1  NM_005296.2  

    Unigene Cluster for LPAR4:

    Lysophosphatidic acid receptor 4
    Hs.522701  [show with all ESTs]
    Unigene Representative Sequence: NM_005296
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000610214 ENST00000435339(uc010nme.3) ENST00000514744 ENST00000607964

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    Additional mRNA sequence: 

    AK314134.1 BC069996.1 BC074722.2 BC095538.1 U90322.1 

    9 DOTS entries:

    DT.211100  DT.121281364  DT.303092  DT.101959737  DT.121281363  DT.121281365  DT.40229716  DT.99978295 
    DT.91748079 

    23 AceView cDNA sequences:

    F03833 BU735774 BC069996 BM697590 F07588 AA424904 BC074722 AA424772 
    AU129897 NM_005296 BX092792 BM973092 U90322 AU126429 AA780191 AA779879 
    CN841728 CK130269 AU151963 W06952 H20663 CN841903 H20571 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LPAR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAACTTCA
    LPAR4 Expression
    About this image


    LPAR4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Chondrocyte-like cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Chondrocyte-like cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
    LPAR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LPAR4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522701

    UniProtKB/Swiss-Prot: LPAR4_HUMAN, Q99677
    Tissue specificity: High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate,
    frontal cortex, pons, hypothalamus and hippocampus

        Pathway & Disease-focused RT2 Profiler PCR Array including LPAR4: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LPAR4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lpar41 , 5 lysophosphatidic acid receptor 41, 5 90.63(n)1
    98.38(a)1
      X (47.39 cM)5
    781341  NM_175271.41  NP_780480.21 
     1069206255 
    chicken
    (Gallus gallus)
    Aves LPAR41 lysophosphatidic acid receptor 4 75.29(n)
    84.77(a)
      422149  NM_001278049.1  NP_001264978.1 
    lizard
    (Anolis carolinensis)
    Reptilia LPAR46
    lysophosphatidic acid receptor 4
    82(a)
    1 ↔ 1
    GL343528.1(280997-282052)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252602 Xenopus laevis transcribed sequence with moderate similarity more 76.46(n)    48052236 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7946981 lysophosphatidic acid receptor 4-like 65.69(n)
    66.96(a)
      794698  XM_001334677.2  XP_001334713.1 


    ENSEMBL Gene Tree for LPAR4 (if available)
    TreeFam Gene Tree for LPAR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LPAR4 gene
    OXGR12  P2RY42  GPR172  P2RY12  P2RY62  GPR1742  LPAR62  LPAR52  
    CYSLTR12  GPR1832  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    Selected SIMAP similar genes for LPAR4 using alignment to 2 protein entries:     LPAR4_HUMAN (see all proteins) (see all similar genes):
    LPAR6    P2RY10    CCR4    KPG_010    LPAR5    GPR17
    P2RY8    CYSLTR2    F2RL1    GPR35    KPG_007    KPG_011
    AGTR1    CXCR1    P2RY4    AGTR2    CCR8    GPR174

    Find genes that share paralogs with LPAR4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LPAR4 (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    rs1887094901,2
    --77973061(+) GCATTA/GAGTTG 2 -- us2k10--------
    rs734938521,2
    C,F--77973106(+) CTTACC/TCTTAT 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1499533541,2
    C--77973146(+) CCTACC/TCTCAC 2 -- us2k10--------
    rs1500077141,2
    C--77973238(+) ATCAT-/CCAACCAA 2 -- us2k10--------
    rs59027721,2
    C--77973367(+) TTTTT-/T/TT  
            
    CAAAA
    2 -- us2k1 trp30--------
    rs1815521061,2
    --77973481(+) TGCACC/TGAGTA 2 -- us2k10--------
    rs39234241,2
    C,F--77973580(-) TCCCCC/TCTCTG 2 -- us2k1 trp33Minor allele frequency- T:0.33NA WA 6
    rs1446885861,2
    C--77973652(+) TTAGAC/GCCAGT 2 -- us2k10--------
    rs1858852551,2
    --77973831(+) GAGGAA/TCCTCC 2 -- us2k10--------
    rs1904845791,2
    --77973967(+) AGAAGC/GCTTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for LPAR4 (78003206 - 78012591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LPAR4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv517n21CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): LPAR4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LPAR4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300086    OMIM disorders: --


    Find genes that share disorders with LPAR4           About GenesLikeMe


    Export disorders for LPAR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LPAR4 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with LPAR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human heptahelical receptor closely related to the P2Y5 receptor. (PubMed id 9223435)1, 2, 9 Janssens R.... Communi D. (Biochem. Biophys. Res. Commun. 1997)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. (PubMed id 12724320)1, 2 Noguchi K.... Shimizu T. (J. Biol. Chem. 2003)
    6. Cloning and chromosomal mapping of four putative novel human G- protein-coupled receptor genes. (PubMed id 9073069)1, 2 O'Dowd B.F.... George S.R. (Gene 1997)
    7. Lysophosphatidic acid receptor 4 signaling potentially modulates malignant behavior in human head and neck squamous cell carcinoma cells. (PubMed id 23467751)1 Matayoshi S....Kato S. (Int. J. Oncol. 2013)
    8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    9. LPA induces osteoblast differentiation through interplay of two receptors: LPA1 and LPA4. (PubMed id 20069565)1 Liu Y.B....Billiard J. (J. Cell. Biochem. 2010)
    10. Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells. (PubMed id 20890765)1 Tsujino M....Tsujiuchi T. (Virchows Arch. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2846 HGNC: 4478 AceView: GPR23 Ensembl:ENSG00000147145 euGenes: HUgn2846
    ECgene: LPAR4 Kegg: 2846 H-InvDB: LPAR4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LPAR4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LPAR4 gene:
    Search GeneIP for patents involving LPAR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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