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LPAR3 Gene

protein-coding   GIFtS: 56
GCID: GC01M085277

Lysophosphatidic Acid Receptor 3

(Previous names: endothelial differentiation, lysophosphatidic acid G-protein-coupled...)
(Previous symbol: EDG7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysophosphatidic Acid Receptor 31 2     GPCR2
EDG71 2 3 5     HOFNH302
LPA32 3 5     LP-A32
Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled
Receptor, 71 2
     RP4-678I32
Lysophosphatidic Acid Receptor Edg-72 3     Calcium-Mobilizing Lysophosphatidic Acid Receptor LP-A32
LPA-32 3     Endothelial Cell Differentiation Gene 72
LPA Receptor 32 3     LPA Receptor EDG72
Edg-72     

External Ids:    HGNC: 142981   Entrez Gene: 235662   Ensembl: ENSG000001715177   OMIM: 6051065   UniProtKB: Q9UBY53   

Export aliases for LPAR3 gene to outside databases

Previous GC identifers: GC01M085048 GC01M083389


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LPAR3 Gene:
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This
protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked
calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. (provided by RefSeq, Jul
2008)

GeneCards Summary for LPAR3 Gene:
LPAR3 (lysophosphatidic acid receptor 3) is a protein-coding gene. Diseases associated with LPAR3 include neuroepithelioma, and ocular albinism. GO annotations related to this gene include lipid binding and G-protein coupled receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in
the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G
proteins

Gene Wiki entry for LPAR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the LPAR3 gene promoter:
         AhR   AP-2rep   Max1   Sox5   Evi-1   C/EBPalpha   POU2F1   POU2F1a   STAT3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPAR3 promoter sequence
   Search Chromatin IP Primers for LPAR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LPAR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

LPAR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M085277:  view genomic region     (about GC identifiers)

Start:
85,277,285 bp from pter      End:
85,358,896 bp from pter
Size:
81,612 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 3  
Size: 353 amino acids; 40128 Da
Secondary accessions: A0AVA3

Explore the universe of human proteins at neXtProt for LPAR3: NX_Q9UBY5

Explore proteomics data for LPAR3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn15, Asn172
  • Modification sites at PhosphoSitePlus

  • See LPAR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036284.1  
    ENSEMBL proteins: 
     ENSP00000395389   ENSP00000359643  
    Reactome Protein details: Q9UBY5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LPAR: GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid

    IUPHAR Guide to PHARMACOLOGY protein family classification: LPA3 receptor
    Lysophospholipid (LPA) receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004065 LPA_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR005385 LPA_rcpt_EDG7

    Graphical View of Domain Structure for InterPro Entry Q9UBY5

    ProtoNet protein and cluster: Q9UBY5

    2 Blocks protein domains:
    IPB004065 Lysophosphatidic acid receptor family signature
    IPB005385 EDG-7 lysophosphatidic acid receptor signature


    UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    LPAR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPAR3_HUMAN, Q9UBY5
    Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in
    the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G
    proteins

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0004930G-protein coupled receptor activity TAS10488122
    GO:0005543phospholipid binding IEA--
    GO:0008289lipid binding TAS10488122
    GO:0070915lysophosphatidic acid receptor activity IEA--
         
    LPAR3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LPAR3:
     Decreased focal adhesion (FA)   Decreased melanin production  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lpar3):
     embryogenesis  homeostasis/metabolism  reproductive system 

    LPAR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lpar3tm1Jch for LPAR3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LPAR3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LPAR3

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    6 qRT-PCR Assays for microRNAs that regulate LPAR3:
    hsa-miR-141 hsa-miR-26a hsa-miR-200a hsa-miR-26b hsa-miR-646 hsa-miR-1297
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LPAR3_HUMAN, Q9UBY5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10488122
    GO:0016021integral component of membrane ----
    GO:0030424axon IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    LPAR3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LPAR3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Ras signaling pathway
    Rap1 signaling pathway0.36
    5PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LPAR3
        RhoA Pathway
    eNOS Signaling
    G12-G13 in Cellular Signaling

    1 BioSystems Pathway for LPAR3
        LPA receptor mediated events

    3 Reactome Pathways for LPAR3
        G alpha (q) signalling events
    Lysosphingolipid and LPA receptors
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for LPAR3):
        Rap1 signaling pathway
    Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway


    LPAR3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including LPAR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LPAR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LPAR3 (Q9UBY53 ENSP000003596434) via UniProtKB, MINT, STRING, and/or I2D (see all 257)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADRA2AENSP000002801554STRING: ENSP00000280155
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS10488122
    GO:0007204positive regulation of cytosolic calcium ion concentration TAS10488122
    GO:0007268synaptic transmission TAS10488122

    LPAR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LPAR3

    10 HMDB Compounds for LPAR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----
    LPA(P-16:0e/0:0)1-(1Z-hexadecenyl)-sn-glycero-3-phosphate;LysoPA(dm16:0e) ----

    Selected IUPHAR Ligands for LPAR3 (LPA3 receptor) (see all 12)    About this table
    LigandTypeActionAffinityPubmed IDs
    alpha-fluoromethylenephosphonate
    AgonistAgonist9.315857137
    2-oleoyl-LPA
    AgonistAgonist810922489
    alkyl OMPT
    AgonistAgonist7.2116892372
    OMPT
    AgonistAgonist7.1712554733
    dodecylphosphate
    AntagonistAntagonist7.0512695531
    dioctanoy?aelglycerol?ae pyrophos?aephate
    AntagonistAntagonist5.5 - 714500756 11562440
    farnesyl diphosphate
    AntagonistAntagonist6.8119366702
    VPC32183
    AntagonistAntagonist6.7615125924
    LPA
    AgonistAgonist6.6910488122
    VPC12249
    AntagonistAntagonist6.3711723223

    Selected Novoseek inferred chemical compound relationships for LPAR3 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysophospholipid 66.1 1 10818447 (1)
    lipid 51.3 24 16093494 (2), 15993425 (2), 18491052 (2), 16246064 (2) (see all 15)
    sphingosine 45.2 1 18058948 (1)
    tyrosine 44.6 14 12548551 (3), 9398658 (1), 14567755 (1), 18558100 (1) (see all 10)
    cyclic amp 41.2 7 18224335 (1), 18606183 (1), 18155068 (1)
    carbachol 35.1 2 12414665 (1), 12743035 (1)
    calcium 28.4 19 10727522 (3), 16228299 (3), 9790898 (1), 18606183 (1) (see all 8)
    phospholipid 18.3 3 15220934 (1), 17452637 (1), 18952848 (1)
    vegf 12.4 5 12668280 (3), 17549306 (1)
    isoproterenol 11.7 1 11358333 (1)



    LPAR3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LPAR3 gene: 
    NM_012152.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440886(uc001dkl.2) ENST00000491034 ENST00000370611(uc009wcj.1)

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      QuantiFast Probe-based Assays in human, mouse, rat LPAR3

    Selected AceView cDNA sequences (see all 33):

    AI223077 BX283404 AY322547 BM999782 BU633960 AI288165 AW274018 AF186380 
    AK091731 AA446859 AW172356 CF121369 AF127138 AI567144 CD103667 BQ775090 
    AI432375 CD557613 NM_012152 BG215668 CB147705 CB140352 BG207736 BG209342 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LPAR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LPAR3 Expression
    About this image


    LPAR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Rib
    LPAR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LPAR3 Protein Expression

    UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
    Tissue specificity: Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in
    lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus,
    small intestine, colon, or peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including LPAR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LPAR3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lpar31 , 5 lysophosphatidic acid receptor 31, 5 84.8(n)1
    91.5(a)1
      3 (71.03 cM)5
    650861  NM_022983.41  NP_075359.11 
     1462209615 
    chicken
    (Gallus gallus)
    Aves LPAR31 lysophosphatidic acid receptor 3 76.16(n)
    82.91(a)
      771215  NM_001113710.1  NP_001107182.1 
    lizard
    (Anolis carolinensis)
    Reptilia LPAR36
    lysophosphatidic acid receptor 3
    82(a)
    1 ↔ 1
    GL343194.1(9940873-9964140)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420028092   -- 72.78(n)    142002809 
    zebrafish
    (Danio rerio)
    Actinopterygii lpar2a1 lysophosphatidic acid receptor 2a 56.32(n)
    49.14(a)
      445184  NM_001003578.2  NP_001003578.1 


    ENSEMBL Gene Tree for LPAR3 (if available)
    TreeFam Gene Tree for LPAR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LPAR3 gene
    CNR12  GPR122  LPAR22  S1PR12  CNR22  S1PR32  S1PR22  LPAR12  
    MC1R2  MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  
    S1PR52  
    10 SIMAP similar genes for LPAR3 using alignment to 1 protein entry:     LPAR3_HUMAN:
    LPAR1    EDG2    LPAR2    EDG1    S1PR1    S1PR3
    S1PR2    S1PR4    S1PR5    GPR3

    LPAR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LPAR3 (see all 1604)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111614621,2
    C,F,A,H--85278665(+) TGTGGG/ACTGGC 1 -- ds5001 ese325Minor allele frequency- A:0.22NS EA NA WA CSA 2355
    rs675818251,2
    C--85278838(+) ATATA-/AGAGAGAGAG
    AGAG
    /ATATATAT
    TATAG
    1 -- ds50010--------
    rs2019049571,2
    C--85278841(+) ATATAG/TAGACA 1 -- ds50010--------
    rs596918461,2
    C--85278842(+) ATATA-/TATA/TA
    TATATATATA
    GACAC
    2 -- ds5001 cds11NA 2
    rs97290141,2
    C,A--85278843(+) ATATAC/G/TACACA 1 -- ds5001 ese32NA 4
    rs3726637841,2
    C--85278844(+) TATAG-/ACACACA 1 -- ds50010--------
    rs97289941,2
    C--85278845(+) ATAGAC/G/TACACA 1 -- ds5001 ese31NA 4
    rs106106381,2
    C--85278867(+) acacaCA/-tgcat 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs106944161,2
    C--85278952(+) ACTTTTAAG/-  
            
    TAAGT
    1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs718466471,2
    C--85278953(+) CTTTT-/TAAG  
            
    AAGTA
    1 -- ds50010--------

    HapMap Linkage Disequilibrium report for LPAR3 (85277285 - 85358896 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LPAR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830448CNV Loss17160897
    nsv470724CNV Gain18288195
    nsv462383CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LPAR3
    DNA2.0 Custom Variant and Variant Library Synthesis for LPAR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605106    OMIM disorders: --

    Selected diseases for LPAR3 (see all 27):    
    About MalaCards
    neuroepithelioma    ocular albinism    albinism    dental caries
    endotheliitis    ovarian cancer    pertussis    obesity
    osteosarcoma    astrocytoma    type 1 diabetes    cervical cancer
    chronic lymphocytic leukemia    prostate cancer    cervicitis    prostatitis
    cerebritis    rheumatoid arthritis    arthritis    sarcoma


    LPAR3 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for LPAR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 37.4 16 19001604 (3), 16018784 (3), 11775454 (1), 12759391 (1)
    cancer 4.23 12 12668280 (2), 20015310 (1), 15220934 (1), 17549306 (1) (see all 9)
    carcinoma squamous cell 0 2 12414665 (1), 12743035 (1)
    necrosis 0 1 16228299 (1)
    inflammation 0 1 18810336 (1)
    adenocarcinoma 0 1 16018784 (1)
    metastasis 0 1 18582227 (1)
    tumors 0 16 19001604 (4), 18582227 (2), 16228299 (1), 17981673 (1) (see all 6)
    prostate cancer 0 4 11832770 (3)
    obesity 0 1 15544445 (1)

    Genetic Association Database (GAD): LPAR3
    Human Genome Epidemiology (HuGE) Navigator: LPAR3 (1 document)

    Export disorders for LPAR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LPAR3 gene, integrated from 10 sources (see all 181):
    (articles sorted by number of sources associating them with LPAR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human G-protein- coupled receptor, EDG7, for lysophosphatidic acid. (PubMed id 10488122)1, 2, 3, 9 Bandoh K.... Inoue K. (J. Biol. Chem. 1999)
    2. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. (PubMed id 10727522)1, 2, 9 Im D.-S.... Lynch K.R. (Mol. Pharmacol. 2000)
    3. Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. (PubMed id 18840781)1, 4 Grant S.F....Hakonarson H. (Diabetes 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Lysophosphatidic acid receptors. (PubMed id 11093753)1, 2 Contos J.J.A.... Chun J. (Mol. Pharmacol. 2000)
    6. Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid. (PubMed id 10891327)1, 9 Fitzgerald L.R.... Tsui P. (Biochem. Biophys. Res. Commun. 2000)
    7. Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. (PubMed id 19001604)1, 9 Yu S....Mills G.B. (J. Natl. Cancer Inst. 2008)
    8. Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. (PubMed id 12668280)1, 9 Fujita T....Nakano H. (Cancer Lett. 2003)
    9. Modulation of myocardial contractility by lysophosphatidic acid (LPA). (PubMed id 12623301)1, 9 Cremers B....BAPhm M. (J. Mol. Cell. Cardiol. 2003)
    10. Enhancement of invasion of hepatocellular carcinoma cells through lysophosphatidic acid receptor. (PubMed id 23569130)1 Lou L....Ding G. (J. Int. Med. Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23566 HGNC: 14298 AceView: EDG7 Ensembl:ENSG00000171517 euGenes: HUgn23566
    ECgene: LPAR3 Kegg: 23566 H-InvDB: LPAR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LPAR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LPAR3 gene:
    Search GeneIP for patents involving LPAR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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