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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LPAR3 Gene

protein-coding   GIFtS: 57
GCID: GC01M085277

lysophosphatidic acid receptor 3

(Previous names: endothelial differentiation, lysophosphatidic acid G-protein-coupled...)
(Previous symbol: EDG7)
 Explore 26 diseases affiliated with
LPAR3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LPAR3    

Aliases
for LPAR3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Lysophosphatidic Acid Receptor 31 2     Lysophosphatidic Acid Receptor Edg-72 3
EDG71 2 3 5     LPA-32 3
LPA31 2 3 5     LPA Receptor 32 3
Edg-71 2     GPCR2
HOFNH301 2     Calcium-Mobilizing Lysophosphatidic Acid Receptor LP-A32
LP-A31 2     Endothelial Cell Differentiation Gene 72
RP4-678I31 2     LPA Receptor EDG72
Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor,
71 2
     

External Ids:    HGNC: 142981   Entrez Gene: 235662   Ensembl: ENSG000001715177   OMIM: 6051065   UniProtKB: Q9UBY53   

Export aliases for LPAR3 gene to outside databases

Previous GC identifers: GC01M085048 GC01M083389


Summaries
for LPAR3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LPAR3:
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This
protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium
mobilization. This receptor couples predominantly to G(q/11) alpha proteins. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the
development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins

Gene Wiki entry for LPAR3


Genomic Views
for LPAR3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LPAR3 gene promoter:
         AhR   AP-2rep   Max1   Sox5   Evi-1   C/EBPalpha   POU2F1   POU2F1a   STAT3   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LPAR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for LPAR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPAR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

LPAR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M085277:  view genomic region     (about GC identifiers)

Start:
 85,277,285 bp from pter      End:
 85,358,896 bp from pter
Size:
 81,612 bases      Orientation:
 minus strand

Proteins
for LPAR3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 3  
Size: 353 amino acids; 40128 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A0AVA3

Explore the universe of human proteins at neXtProt for LPAR3: NX_Q9UBY5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBY5

    • LPAR3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036284.1  
    ENSEMBL proteins: 
     ENSP00000395389   ENSP00000359643  
    Reactome Protein details: Q9UBY5
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    Uscn Proteins for LPAR3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10488122
    GO:0043231intracellular membrane-bounded organelle IDA--


    LPAR3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for LPAR3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LPAR3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR005385 LPA_rcpt_EDG7
     IPR004065 LPA_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9UBY5

    ProtoNet protein and cluster: Q9UBY5

    2 Blocks protein families:
    IPB004065 Lysophosphatidic acid receptor family signature
    IPB005385 EDG-7 lysophosphatidic acid receptor signature


    UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for LPAR3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
    Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the
    development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins

    miRNA
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    hsa-miR-141 hsa-miR-26a hsa-miR-200a hsa-miR-26b hsa-miR-646 hsa-miR-1297
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001619lysosphingolipid and lysophosphatidic acid receptor activity ----
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0004930G-protein coupled receptor activity TAS10488122
    GO:0005543phospholipid binding IEA--
    GO:0008289lipid binding TAS10488122


    LPAR3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for LPAR3:
     Decreased focal adhesion (FA)   Decreased melanin production  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Lpar3tm1Jch for LPAR3
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Lpar3):
     embryogenesis  homeostasis/metabolism  reproductive system 

    LPAR3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LPAR3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3G alpha (q) signalling events
    		G alpha (q) signalling events1.00
    		Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Lysosphingolipid and LPA receptors
    		Lysosphingolipid and LPA receptors1.00
    5LPA receptor mediated events
    		LPA receptor mediated events1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for LPAR3 
        LPA receptor mediated events

    5/9        Reactome Pathways for LPAR3 (see all 9)
        GPCR downstream signaling
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)


    1         Kegg Pathway  (Kegg details for LPAR3):
        Neuroactive ligand-receptor interaction


    LPAR3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LPAR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/257 Interacting proteins for LPAR3 (Q9UBY53 ENSP000003596434) via UniProtKB, MINT, STRING, and/or I2D (see all 257)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADRA2AENSP000002801554STRING: ENSP00000280155
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    CXCR5ENSP000002921744STRING: ENSP00000292174
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS10488122
    GO:0007204elevation of cytosolic calcium ion concentration TAS10488122
    GO:0007268synaptic transmission TAS10488122


    LPAR3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LPAR3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LPAR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for LPAR3

    10 HMDB Compounds for LPAR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----
    LPA(P-16:0e/0:0)1-(1Z-hexadecenyl)-sn-glycero-3-phosphate;LysoPA(dm16:0e) ----
    10/18 Novoseek chemical compound relationships for LPAR3 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysophospholipid 66.1 1 10818447 (1)
    lipid 51.3 24 16093494 (2), 15993425 (2), 18491052 (2), 16246064 (2) (see all 15)
    sphingosine 45.2 1 18058948 (1)
    tyrosine 44.6 14 12548551 (3), 9398658 (1), 14567755 (1), 18558100 (1) (see all 10)
    cyclic amp 41.2 7 18224335 (1), 18606183 (1), 18155068 (1)
    carbachol 35.1 2 12414665 (1), 12743035 (1)
    calcium 28.4 19 10727522 (3), 16228299 (3), 9790898 (1), 18606183 (1) (see all 8)
    phospholipid 18.3 3 15220934 (1), 17452637 (1), 18952848 (1)
    vegf 12.4 5 12668280 (3), 17549306 (1)
    isoproterenol 11.7 1 11358333 (1)

    Search CenterWatch for drugs/clinical trials and news about LPAR3 

    Transcripts
    for LPAR3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LPAR3 gene: 
    NM_012152.2  

    Unigene Cluster for LPAR3:

    Lysophosphatidic acid receptor 3
    Hs.674915  [show with all ESTs]
    Unigene Representative Sequence: NM_012152
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440886(uc001dkl.2) ENST00000491034 ENST00000370611(uc009wcj.1)


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    Additional cDNA sequence: 

    AF127138.1 AF186380.1 AF236117.1 AK308283.1 AY322547.1 BC126268.1 BC126270.1 BC144021.1 

    4 DOTS entries:

    DT.91754582  DT.91816580  DT.91798222  DT.91926752 

    24/33 AceView cDNA sequences (see all 33):

    BU633960 AY322547 AF186380 BM999782 AI223077 AW274018 AI288165 BX283404 
    CB140352 CD557613 AI432375 BQ775090 AF127138 BG215668 CD103667 CB147705 
    AW172356 AI567144 AA446859 AK091731 CF121369 NM_012152 BG209342 BG207736 

    GeneLoc Exon Structure


    Expression
    for LPAR3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LPAR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LPAR3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneThoracic RibBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LPAR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LPAR3

    SOURCE GeneReport for Unigene cluster: Hs.674915

    UniProtKB/Swiss-Prot: LPAR3_HUMAN, Q9UBY5
    Tissue specificity: Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung
    and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small
    intestine, colon, or peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including LPAR3: 
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    In Situ
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    Orthologs
    for LPAR3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LPAR3 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LPAR31 lysophosphatidic acid receptor 3 76.29(n)
    83.14(a)    		   771215  NM_001113710.1  NP_001107182.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LPAR36
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343194.1(9944176-9964140)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1420028092   -- 72.78(n)    142002809 


    ENSEMBL Gene Tree for LPAR3 (if available)
    TreeFam Gene Tree for LPAR3 (if available) 

    Paralogs
    for LPAR3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LPAR3 gene
    CNR12  GPR122  ENSG000002675342  LPAR22  S1PR12  CNR22  S1PR32  LPAR12  
    MC1R2  MC3R2  MC5R2  GPR32  MC2R2  MC4R2  S1PR42  GPR62  
    S1PR52  
    10 SIMAP similar genes for LPAR3 using alignment to 1 protein entry:     LPAR3_HUMAN:
    LPAR1    EDG2    LPAR2    EDG1    S1PR1    S1PR3
    S1PR2    S1PR4    S1PR5    GPR3

    LPAR3 for paralogs           About GeneDecksing



    Genomic Variants
    for LPAR3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1374 NCBI SNPs in LPAR3 are shown (see all 1374)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs111614621,2
    		C,F,A,H,--85278665(+) TGTGGG/ACTGGC 1 -- ds5001 ese325Minor allele frequency- A:0.22NS EA NA WA CSA 2355
    rs97290141,2
    		C,A--85278843(+) ATATAC/G/TACACA 1 -- ds5001 ese32NA 4
    rs97289941,2
    		C--85278845(+) ATAGAC/G/TACACA 1 -- ds5001 ese31NA 4
    rs106106381,2
    		C--85278845(+) acacaCA/-tgcat 1 -- ds50011Minor allele frequency- -:0.50NA 2
    rs106944161,2
    		C,--85278952(+) ACTTTTAAG/-  
                TAAGT     		1 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs562509141,2
    		C--85278958(+) AAGTAAGTA/-  
                TTTTT     		1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1164258901,2
    		C,F,--85279050(+) GCTACT/CGGCCA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs97290181,2
    		C,F,A,H,--85279077(+) AAAAAT/CACCAT 1 -- ds500124Minor allele frequency- C:0.19NS EA NA WA CSA 2345
    rs1838712481,2
    		--85279238(+) CGAAAC/TGGTGC 1 -- ut310--------
    rs2020752371,2
    		--85279286(+) TGAGC-/AGTTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LPAR3 (85277285 - 85358896 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LPAR3: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for LPAR3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LPAR3 for disorders           About GeneDecksing

    OMIM gene information: 605106    OMIM disorders: --

    20/26 diseases for LPAR3 (see all 26):    About MalaCards
    ocular albinism    albinism    chronic lymphocytic leukemia    lymphocytic leukemia
    neuroepithelioma    squamous cell carcinoma    rheumatoid arthritis    ovarian cancer
    prostate cancer    obesity    pertussis    ovarian carcinoma
    colon cancer    arthritis    gastric cancer    colorectal cancer
    leukemia    osteosarcoma    astrocytoma    lung cancer

    10 Novoseek disease relationships for LPAR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 37.4 16 19001604 (3), 16018784 (3), 11775454 (1), 12759391 (1)
    cancer 4.23 12 12668280 (2), 20015310 (1), 15220934 (1), 17549306 (1) (see all 9)
    carcinoma squamous cell 0 2 12414665 (1), 12743035 (1)
    necrosis 0 1 16228299 (1)
    inflammation 0 1 18810336 (1)
    adenocarcinoma 0 1 16018784 (1)
    metastasis 0 1 18582227 (1)
    tumors 0 16 19001604 (4), 18582227 (2), 16228299 (1), 17981673 (1) (see all 6)
    prostate cancer 0 4 11832770 (3)
    obesity 0 1 15544445 (1)

    Human Genome Epidemiology (HuGE) Navigator: LPAR3 (1 document)

    Export disorders for LPAR3 gene to outside databases

    Publications
    for LPAR3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LPAR3 gene, integrated from 9 sources (see all 173):
    (articles sorted by number of sources associating them with LPAR3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human G-protein- coupled receptor, EDG7, for lysophosphatidic acid. (PubMed id 10488122)1, 2, 3, 9 Bandoh K.... Inoue K. (1999)
    2. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. (PubMed id 10727522)1, 2, 9 Im D.-S.... Lynch K.R. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Lysophosphatidic acid receptors. (PubMed id 11093753)1, 2 Contos J.J.A.... Chun J. (2000)
    5. Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid. (PubMed id 10891327)1, 9 Fitzgerald L.R.... Tsui P. (2000)
    6. Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. (PubMed id 19001604)1, 9 Yu S....Mills G.B. (2008)
    7. Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer. (PubMed id 12668280)1, 9 Fujita T....Nakano H. (2003)
    8. Modulation of myocardial contractility by lysophosphatidic acid (LPA). (PubMed id 12623301)1, 9 Cremers B....Bohm M. (2003)
    9. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    10. Lysophosphatidic acid receptor 2/3-mediated IL-8-depen dent angiogenesis in cervical cancer cells. (PubMed id 21964883)1 Chen R.J....Lin M.C. (2012)

    External Searches for LPAR3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing LPAR3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23566 HGNC: 14298 AceView: EDG7 Ensembl:ENSG00000171517 euGenes: HUgn23566
    ECgene: LPAR3 Kegg: 23566 H-InvDB: LPAR3

    Other Databases showing LPAR3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LPAR3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LPAR3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LPAR3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LPAR3 gene:
    Search GeneIP for patents involving LPAR3

    GeneCards and IP:
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