Aliases for LPAR2 Gene
External Ids for LPAR2 Gene
Previous HGNC Symbols for LPAR2 Gene
Previous GeneCards Identifiers for LPAR2 Gene
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for LPAR2 Gene
LPAR2 (Lysophosphatidic Acid Receptor 2) is a Protein Coding gene. Diseases associated with LPAR2 include Ovarian Cancer, Somatic. Among its related pathways are Regulation of CFTR activity (norm and CF) and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is LPAR1.
UniProtKB/Swiss-Prot for LPAR2 Gene
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.