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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LPAR2 Gene

protein-coding   GIFtS: 59
GCID: GC19M019734

lysophosphatidic acid receptor 2

(Previous names: endothelial differentiation, lysophosphatidic acid G-protein-coupled...)
(Previous symbol: EDG4)
 Explore 23 diseases affiliated with
LPAR2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LPAR2    

Aliases
for LPAR2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Lysophosphatidic Acid Receptor 21 2     LPA-22 3
EDG41 2 3 5     LPA Receptor 22 3
LPA21 2 3     G Protein-Coupled Receptor2
EDG-41 2     LPA Receptor EDG42
Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor,
41 2
     Lysophosphatidic Acid Receptor EDG42
Lysophosphatidic Acid Receptor Edg-42 3     

External Ids:    HGNC: 31681   Entrez Gene: 91702   Ensembl: ENSG000000645477   OMIM: 6051105   UniProtKB: Q9HBW03   

Export aliases for LPAR2 gene to outside databases

Previous GC identifers: GC19M019597 GC19M019296


Summaries
for LPAR2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LPAR2:
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This
protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular
response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been
described but its full length sequence has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to
the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta
(PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA
activation

Gene Wiki entry for LPAR2


Genomic Views
for LPAR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LPAR2 gene promoter:
         PPAR-gamma1   p53   Olf-1   SEF-1 (1)   IRF-7A   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LPAR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LPAR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPAR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p12

LPAR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019734:  view genomic region     (about GC identifiers)

Start:
 19,734,464 bp from pter      End:
 19,739,739 bp from pter
Size:
 5,276 bases      Orientation:
 minus strand

Proteins
for LPAR2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 2  
Size: 351 amino acids; 39084 Da
Subunit: Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and ADRBK1
Subcellular location: Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found
predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles
Miscellaneous: PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal
coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and
may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells
that formed a tumor
Sequence caution: Sequence=AAC27728.1; Type=Frameshift; Positions=348;
Secondary accessions: O00543 O43431

Explore the universe of human proteins at neXtProt for LPAR2: NX_Q9HBW0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HBW0

    • LPAR2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004711.2  
    ENSEMBL proteins: 
     ENSP00000465280   ENSP00000384665   ENSP00000443256   ENSP00000468132   ENSP00000466112  
     ENSP00000465206   ENSP00000466940  
    Reactome Protein details: Q9HBW0
    Human Recombinant Protein Products: 
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    Novus Biologicals LPAR2 Proteins
    Novus Biologicals LPAR2 Lysate
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    Uscn Proteins for LPAR2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9525886
    GO:0009986cell surface IDA19306925
    GO:0030139colocalizes with endocytic vesicle IDA19306925


    LPAR2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for LPAR2

    Protein Domains /
    Families
    for LPAR2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LPAR2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004066 LPA_rcpt_EDG4
     IPR004065 LPA_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9HBW0

    ProtoNet protein and cluster: Q9HBW0

    2 Blocks protein families:
    IPB004065 Lysophosphatidic acid receptor family signature
    IPB004066 EDG-4 lysophosphatidic acid receptor signature


    UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for LPAR2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0
    Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to
    the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta
    (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA
    activation

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LPAR2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate LPAR2:
    hsa-miR-299-5p hsa-miR-4324 hsa-miR-345 hsa-miR-143
    SwitchGear 3'UTR luciferase reporter plasmid: LPAR2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LPAR2 (see all 4)
    OriGene shRNA RFP: LPAR2
    OriGene siRNA: LPAR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LPAR2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LPAR2

    Clone
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    GenScript: all cDNA clones in your preferred vector: LPAR2 (NM_004720)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPAR2 

    Cell Line
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    Search LifeMap BioReagents cell lines for LPAR2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS9525886
    GO:0005515protein binding IPI16203867
    GO:0008289lipid binding TAS9525886
    GO:0030165PDZ domain binding IEA--
    GO:0030274LIM domain binding ----


    LPAR2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for LPAR2:
     Decreased POU5F1-GFP protein e 

    Animal Models:
         Mouse knock-outs for LPAR2: Lpar2tm1Jch Lpar2tm1Dgen
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lpar2):
     behavior/neurological  growth/size  immune system  mortality/aging  nervous system 
     normal  respiratory system 

    LPAR2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for LPAR2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3G alpha (q) signalling events
    		G alpha (q) signalling events1.00
    		Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Lysosphingolipid and LPA receptors
    		Lysosphingolipid and LPA receptors1.00
    5LPA receptor mediated events
    		LPA receptor mediated events1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for LPAR2
        Regulation of CFTR activity (norm and CF)

    1 BioSystems Pathway for LPAR2 
        LPA receptor mediated events

    5/9        Reactome Pathways for LPAR2 (see all 9)
        GPCR downstream signaling
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)


    1         Kegg Pathway  (Kegg details for LPAR2):
        Neuroactive ligand-receptor interaction


    LPAR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LPAR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/265 Interacting proteins for LPAR2 (Q9HBW01, 3 ENSP000003846654) via UniProtKB, MINT, STRING, and/or I2D (see all 265)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CFTRP135691, 3, ENSP000000030844EBI-765995,EBI-349854 I2D: score=1 STRING: ENSP00000003084
    SLC9A3R2Q155991, 3, ENSP000004080054EBI-765995,EBI-1149760 I2D: score=4 STRING: ENSP00000408005
    ARHGEF11O150853, ENSP000003571774I2D: score=1 STRING: ENSP00000357177
    ARHGEF12Q9NZN53, ENSP000003809424I2D: score=1 STRING: ENSP00000380942
    SIVA1O153043, ENSP000003292134I2D: score=1 STRING: ENSP00000329213
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS9525886
    GO:0007202activation of phospholipase C activity TAS9804623
    GO:0007204elevation of cytosolic calcium ion concentration TAS9804623
    GO:0035025positive regulation of Rho protein signal transduction IEA--


    LPAR2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LPAR2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LPAR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LPAR2

    10/13 HMDB Compounds for LPAR2 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    8 Novoseek chemical compound relationships for LPAR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysophospholipid 76.9 2 10729222 (1), 10753843 (1)
    phospholipid 51.1 3 15220934 (1), 15755723 (1), 16890224 (1)
    lysophosphatidylcholine 46.9 1 20197381 (1)
    lipid 38.5 1 15280372 (1)
    pertussis 37.6 2 9804623 (1)
    vegf 31.2 5 12668280 (3), 19001604 (1), 20197381 (1)
    calcium 1.81 15 9804623 (8), 18178086 (1)
    fatty acid 0 2 10488122 (1)

    Search CenterWatch for drugs/clinical trials and news about LPAR2 

    Transcripts
    for LPAR2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LPAR2 gene: 
    NM_004720.5  

    Unigene Cluster for LPAR2:

    Lysophosphatidic acid receptor 2
    Hs.122575  [show with all ESTs]
    Unigene Representative Sequence: AK123043
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586703 ENST00000407877(uc002nnb.4 uc002nna.4) ENST00000542587(uc002nnc.4)
    ENST00000591042 ENST00000588233 ENST00000592061 ENST00000588461 ENST00000590629
    ENST00000589311

    miRNA
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    hsa-miR-299-5p hsa-miR-4324 hsa-miR-345 hsa-miR-143
    SwitchGear 3'UTR luciferase reporter plasmid: LPAR2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF011466.1 AF197929.1 AF233092.1 AK123043.1 AK316573.1 AY322548.1 BC025695.1 

    11 DOTS entries:

    DT.411501  DT.100777864  DT.121493202  DT.101979545  DT.86857033  DT.121493024  DT.121493161  DT.95267721 
    DT.95308057  DT.95342006  DT.121493146 

    24/71 AceView cDNA sequences (see all 71):

    CR598581 BM840024 NM_004720 BM725367 AU124778 AF233092 CR623876 BX279964 
    AL552902 AU133824 BC025695 BM720743 AA470437 BX328368 AF197929 CA454658 
    AI224123 AY322548 BM841410 BI915073 BU687227 AI620928 BX441114 BI830830 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for LPAR2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h · 5i ^ 6
    SP1:              -     -                             -     -           -                                                         
    SP2:              -                                   -     -           -                                                         
    SP3:              -     -     -     -     -     -     -     -           -                                                         
    SP4:                                -     -     -     -     -           -                                                         
    SP5:                                -     -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for LPAR2

    Expression
    for LPAR2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LPAR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTACCCGGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LPAR2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    Neural TubeMesencephalic Roof PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LPAR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LPAR2

    SOURCE GeneReport for Unigene cluster: Hs.122575

    UniProtKB/Swiss-Prot: LPAR2_HUMAN, Q9HBW0
    Tissue specificity: Expressed most abundantly in testes and peripheral blood leukocytes with less expression in
    pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal
    muscle, kidney, ovary, small intestine, or colon

        SABiosciences Expression via Pathway-Focused PCR Arrays including LPAR2: 
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    Orthologs
    for LPAR2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for LPAR2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Lpar21 , 5 lysophosphatidic acid receptor 21, 5 86.59(n)1
    92.24(a)1    		   8 (33.91 cM)5
    539781  NM_020028.31  NP_064412.21 
     698225655 
    chicken
    (Gallus gallus)    		 Aves LPAR21 lysophosphatidic acid receptor 2 68.8(n)
    67.65(a)    		   426086  NM_001115081.1  NP_001108553.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LPAR26
    		 --
    		 67(a)
    		 1 ↔ 1
    		 GL343198.1(4088156-4103644)
    zebrafish
    (Danio rerio)    		 Actinopterygii 570708112   -- 74.64(n)    57070811 


    ENSEMBL Gene Tree for LPAR2 (if available)
    TreeFam Gene Tree for LPAR2 (if available) 

    Paralogs
    for LPAR2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LPAR2 gene
    CNR12  GPR122  ENSG000002675342  S1PR12  CNR22  S1PR32  LPAR12  MC1R2  
    MC3R2  MC5R2  GPR32  MC2R2  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    12 SIMAP similar genes for LPAR2 using alignment to 6 protein entries:     LPAR2_HUMAN (see all proteins):
    LPAR1    EDG2    MC5R    LPAR3    EDG1    S1PR1
    S1PR3    S1PR4    S1PR5    GPR3    S1PR2    GPR12

    LPAR2 for paralogs           About GeneDecksing



    Genomic Variants
    for LPAR2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/118 NCBI SNPs in LPAR2 are shown (see all 118)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs48089741,2
    		C,F,A,--19733964(+) TAGCCG/AAGTGT 1 -- ds50016Minor allele frequency- A:0.12NA WA EA 364
    rs72475941,2
    		C,F,--19733967(+) CCGAGT/CGTAGT 1 -- ds50015Minor allele frequency- C:0.17NA EA 246
    rs1462657621,2
    		--19734050(+) GCAGTA/GACCTG 1 -- ds50010--------
    rs1394450551,2
    		--19734052(+) AGTAAC/GCTGAG 1 -- ds50010--------
    rs72471651,2
    		C,F,--19734164(+) TGGACG/ATGGTG 1 -- ds50015Minor allele frequency- A:0.29NA EA 246
    rs1124484311,2
    		--19734175(+) GCACGC/TGCCTG 1 -- ds50012Minor allele frequency- T:0.17CSA WA 120
    rs1440787511,2
    		--19734379(+) TACCAG/TGTTGA 1 -- ds50010--------
    rs1460059211,2
    		--19734519(+) TCCCCA/GTGGAC 1 -- ut310--------
    rs1854709301,2
    		--19734521(+) CCCGTA/GGACTG 1 -- ut310--------
    rs801699801,2
    		C,F,--19734537(+) ATTCTA/GTCGGG 1 -- ut311Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for LPAR2 (19734464 - 19739739 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LPAR2: --

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    Disorders / Diseases
    for LPAR2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LPAR2 for disorders           About GeneDecksing

    OMIM gene information: 605110    OMIM disorders: --

    20/23 diseases for LPAR2 (see all 23):    About MalaCards
    secretory diarrhea    malignant pleural mesothelioma    chronic lymphocytic leukemia    lymphocytic leukemia
    diarrhea    colon cancer    ovarian cancer    gastric cancer
    colorectal cancer    endometrial cancer    cholera    colon carcinoma
    pertussis    ovarian carcinoma    carcinoma    thyroid cancer
    lung carcinoma    breast carcinoma    thyroiditis    leukemia

    8 Novoseek disease relationships for LPAR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 50.8 17 19001604 (3), 18461672 (2), 10818454 (1), 11775454 (1) (see all 7)
    cancer 32.2 18 16353194 (4), 12668280 (2), 19025891 (1), 9525886 (1) (see all 10)
    colon cancer 22.1 8 15728708 (3), 15837931 (2), 12670925 (1), 16904289 (1)
    tumors 18.8 14 19001604 (5), 16353194 (2), 19025891 (1), 18178086 (1) (see all 6)
    metastasis 12.9 2 19081821 (1), 19116446 (1)
    breast cancer 0 3 10493533 (1), 15535846 (1), 19609003 (1)
    gastric cancer 0 3 16353194 (2), 15530853 (1)
    colorectal cancer 0 6 15220934 (3), 15837931 (1)


    Export disorders for LPAR2 gene to outside databases

    Publications
    for LPAR2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LPAR2 gene, integrated from 9 sources (see all 101):
    (articles sorted by number of sources associating them with LPAR2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. (PubMed id 9525886)1, 2, 3, 9 An S.... Goetzl E.J. (1998)
    2. Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. (PubMed id 9804623)1, 3, 9 An S....Goetzl E.J. (1998)
    3. MAGI-3 regulates LPA-induced activation of Erk and RhoA. (PubMed id 16904289)1, 2, 9 Zhang H....Yun C.C. (2007)
    4. NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. (PubMed id 15143197)1, 2, 9 Oh Y.-S.... Suh P.-G. (2004)
    5. Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. (PubMed id 10729222)1, 2, 9 Contos J.J.A. and Chun J. (2000)
    6. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PubMed id 19306925)1, 2, 9 Aziziyeh A.I....Bhattacharya M. (2009)
    7. Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. (PubMed id 10922489)1, 2, 9 Bandoh K.... Inoue K. (2000)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Lysophosphatidic acid receptors. (PubMed id 11093753)1, 2 Contos J.J.A.... Chun J. (2000)

    External Searches for LPAR2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LPAR2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9170 HGNC: 3168 AceView: EDG4 Ensembl:ENSG00000064547 euGenes: HUgn9170
    ECgene: LPAR2 Kegg: 9170 H-InvDB: LPAR2

    Other Databases showing LPAR2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LPAR2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LPAR2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LPAR2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LPAR2 gene:
    Search GeneIP for patents involving LPAR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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