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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LPAR1 Gene

protein-coding GIFtS: 62
GCID: GC09M113635

lysophosphatidic acid receptor 1

(Previous names: endothelial differentiation, lysophosphatidic acid G-protein-coupled...)
(Previous symbol: EDG2)

Explore 39 diseases affiliated with
LPAR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysophosphatidic Acid Receptor 1¹ ²		Rec.1.3¹
EDG2¹ ² ³ ⁵		Vzg-1¹
LPA1¹ ² ³ ⁵		Lysophosphatidic Acid Receptor Edg-2² ³
GPR26¹ ²		LPA-1² ³
Gpcr26¹ ²		LPA Receptor 1² ³
Mrec1.3¹ ²		VZG1² ⁵
Edg-2¹		Ventricular Zone Gene 1²
Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor, 2¹ ²

External Ids:	HGNC: 3166¹	Entrez Gene: 1902²	Ensembl: ENSG00000198121⁷	OMIM: 602282⁵	UniProtKB: Q92633³

Export aliases for LPAR1 gene to outside databases

Previous GC identifers: GC09M112676 GC09M083234

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LPAR1:

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG

receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell

signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth

muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two

transcript variants encoding the same protein have been identified for this gene (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633

Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to

the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in

a manner that is dependent on RALA activation

Gene Wiki entry for LPAR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LPAR1 gene promoter:
PPAR-gamma1 AP-1 ATF-2 PPAR-gamma2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LPAR1 promoter sequence

Search SABiosciences Chromatin IP Primers for LPAR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPAR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3 Ensembl cytogenetic band: 9q31.3 HGNC cytogenetic band: 9q

LPAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M113635: view genomic region (about GC identifiers)

Start:	113,635,543 bp from pter	End:	113,800,981 bp from pter
Size:	165,439 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633 (See protein sequence)

Recommended Name: Lysophosphatidic acid receptor 1

Size: 364 amino acids; 41109 Da

Subunit: Interacts with RALA and ADRBK1

Subcellular location: Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found

predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles

Secondary accessions: O00656 O00722 P78351

Explore the universe of human proteins at neXtProt for LPAR1: NX_Q92633

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92633

LPAR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001392.2 NP_476500.1

ENSEMBL proteins:

ENSP00000363553 ENSP00000363552 ENSP00000351755 ENSP00000401810 ENSP00000440201

ENSP00000445697

Reactome Protein details: Q92633
Human Recombinant Protein Products for LPAR1:

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	Uscn Proteins for LPAR1

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9070858
GO:0009986	cell surface	IDA	19306925
GO:0016021	integral to membrane	--	--

LPAR1 for ontologies About GeneDecksing

LPAR1 Antibody Products:

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	Uscn ELISAs and CLIAs for LPAR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LPAR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR004065 LPA_rcpt

IPR000276 GPCR_Rhodpsn

IPR002277 LPA_rcpt_EDG2

Graphical View of Domain Structure for InterPro Entry Q92633

ProtoNet protein and cluster: Q92633

2 Blocks protein families:

IPB002277 Lysophosphatidic acid receptor (EDG2) signature

IPB004065 Lysophosphatidic acid receptor family signature

UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LPAR1_HUMAN, Q92633

Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to

the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in

a manner that is dependent on RALA activation

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001619	lysosphingolipid and lysophosphatidic acid receptor activity	--	--
GO:0001965	G-protein alpha-subunit binding	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	8922387
GO:0005515	protein binding	IPI	19306925
GO:0005543	phospholipid binding	IEA	--

LPAR1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for LPAR1:

Increased gamma-H2AX phosphory

Synthetic lethal with paclitax

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lpar1):

adipose tissue	behavior/neurological	cardiovascular system	craniofacial	growth/size
homeostasis/metabolism	mortality/aging	nervous system	vision/eye

LPAR1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Lpar1^tm1Jch for LPAR1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LPAR1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): LPAR1 Browse MicroRNA Expression Plasmids
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		hsa-miR-3910 hsa-miR-217 hsa-miR-323-3p hsa-miR-892b hsa-miR-429 hsa-miR-4263 hsa-miR-374a hsa-miR-138-2*

		SwitchGear 3'UTR luciferase reporter plasmid: LPAR1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			G alpha (i) signalling events	0.44
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Lysosphingolipid and LPA receptors

Lysosphingolipid and LPA receptors

1.00

LPA receptor mediated events

LPA receptor mediated events

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 BioSystems Pathways for LPAR1

	Myometrial Relaxation and Contraction Pathways
	LPA receptor mediated events
	Small Ligand GPCRs

5/9 Reactome Pathways for LPAR1 (see all 9)

	GPCR downstream signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)

2 Kegg Pathways (Kegg details for LPAR1):

	Neuroactive ligand-receptor interaction
	Gap junction

LPAR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LPAR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/269 Interacting proteins for LPAR1 (Q92633³ ENSP00000351755⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 269)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGEF11	O15085³, ENSP00000357177⁴	I2D: score=1 STRING: ENSP00000357177
ARHGEF12	Q9NZN5³, ENSP00000380942⁴	I2D: score=1 STRING: ENSP00000380942
GNAI3	P08754³, ENSP00000358867⁴	I2D: score=1 STRING: ENSP00000358867
SLC9A3R2	Q15599³, ENSP00000408005⁴	I2D: score=1 STRING: ENSP00000408005
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8922387
GO:0007202	activation of phospholipase C activity	TAS	9804623
GO:0007204	elevation of cytosolic calcium ion concentration	TAS	9804623
GO:0010942	positive regulation of cell death	--	--

LPAR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LPAR1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LPAR1

10 HMDB Compounds for LPAR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
LPA(0:0/16:0)	Lysophosphatidic acid(16:0) (see all 6)	--	--
LPA(0:0/18:0)	2-octadecanoyl-phosphatidic acid (see all 6)	--	--
LPA(0:0/18:1(9Z))	LPA(18:1) (see all 10)	--	--
LPA(0:0/18:2(9Z,12Z))	LPA(0:0/18:2n6) (see all 10)	--	--
LPA(16:0/0:0)	Lysophosphatidic acid(16:0/0:0) (see all 14)	--	--
LPA(18:0/0:0)	1-octadecanoyl-phosphatidic acid (see all 6)	--	--
LPA(18:0e/0:0)	[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)	--	--
LPA(18:1(9Z)/0:0)	1-oleoyl-glycero-3-phosphate (see all 26)	--	--
LPA(18:2(9Z,12Z)/0:0)	LPA(18:2w6/0:0) (see all 10)	--	--
LPA(P-16:0e/0:0)	1-(1Z-hexadecenyl)-sn-glycero-3-phosphate;LysoPA(dm16:0e)	--	--

10/11 Novoseek chemical compound relationships for LPAR1 gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lysophospholipid	84.2	2	9931453 (1), 11604399 (1)
diacylglycerol pyrophosphate	75.6	1	15618220 (1)
lysophosphatidylcholine	59	2	16627485 (1)
phospholipid	56	3	11604399 (1), 15220934 (1), 15755723 (1)
pertussis	50.7	2	9804623 (1)
lipid	45.4	5	11723085 (1), 17156449 (1), 19081821 (1), 16210650 (1) (see all 5)
vegf	24.6	2	20197381 (2)
calcium	1.98	13	9804623 (8)
arginine	0	2	15755723 (1), 18316373 (1)
cisplatin	0	2	10632375 (2)

Search CenterWatch for drugs/clinical trials and news about LPAR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LPAR1 gene (2 alternative transcripts):

NM_001401.3 NM_057159.2

Unigene Cluster for LPAR1:

Lysophosphatidic acid receptor 1

Hs.126667 [show with all ESTs]

Unigene Representative Sequence: BC036034

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374431(uc004bfb.3 uc004bfc.3 uc011lwn.2 uc010mub.3)

ENST00000374430(uc004bfa.3 uc011lwm.2) ENST00000358883 ENST00000441240

ENST00000538760 ENST00000541779(uc011lwo.2)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LPAR1

Additional cDNA sequence:

AK022808.1 AK290287.1 AK296374.1 AK298590.1 AK299279.1 AY322546.1 BC030615.2 BC036034.1

BC073167.1 U78192.1 U80811.1 Y09479.1

11 DOTS entries:

DT.97769991 DT.91735433 DT.91757548 DT.92026247 DT.121173151 DT.121173152 DT.121173154 DT.95135082

DT.121173114 DT.121173164 DT.91672717

24/151 AceView cDNA sequences (see all 151):

AY322546 F06566 BX114078 AI086284 BQ898218 BE464013 NM_001401 NM_057159

AA150119 AI161252 BC073167 BQ446451 BX952663 BQ019924 BQ183686 BE140638

CB241026 AI272801 AW953091 BC036034 AU120057 AI168217 BU838473 AI674417

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for LPAR1 (see all 9) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	^	12
SP1:																	-		-		-		-
SP2:															-		-		-		-		-								-
SP3:																	-		-		-		-								-
SP4:																															-
SP5:			-		-		-		-		-		-		-		-		-		-		-								-

ECgene alternative splicing isoforms for LPAR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LPAR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGGCAGTT

About this image

LPAR1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LPAR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LPAR1

SOURCE GeneReport for Unigene cluster: Hs.126667

UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633

Tissue specificity: Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate,

ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or

peripheral blood leukocytes

SABiosciences Expression via Pathway-Focused PCR Arrays including LPAR1:

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Gap Junctions in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LPAR1 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LPAR1¹	lysophosphatidic acid receptor 1	83.76(n) 95.77(a)		427339 NM_001115082.1 NP_001108554.1
lizard (Anolis carolinensis)	Reptilia	LPAR1⁶	--	91(a)	1 ↔ 1	GL343463.1(521085-556078)
African clawed frog (Xenopus laevis)	Amphibia	edg2-A²	lysophosphatidic acid G-protein-coupled receptor 2	80.56(n)		AJ249844.1
zebrafish (Danio rerio)	Actinopterygii	lpar1¹	lysophosphatidic acid receptor 1	76.49(n) 89.31(a)		368461 NM_001004502.2 NP_001004502.2

ENSEMBL Gene Tree for LPAR1 (if available)
TreeFam Gene Tree for LPAR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for LPAR1 gene

CNR1² GPR12² ENSG00000267534² LPAR2² S1PR1² CNR2² S1PR3² MC1R²

MC3R² MC5R² GPR3² MC2R² MC4R² S1PR4² GPR6² LPAR3²

S1PR5²

15 SIMAP similar genes for LPAR1 using alignment to 5 protein entries: LPAR1_HUMAN (see all proteins):

EDG2 LPAR2 LPAR3 EDG1 S1PR1 HTR5A

S1PR3 S1PR2 MC4R S1PR5 MC5R MC3R

S1PR4 CHRM2 GPR3

LPAR1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6833^1,2	C,F,O,A,H	--	113635691(-)	`TGCACG/ATACTT`	2	--	int¹ ese³		27		MN NA NS EA WA CSA	2862
rs145053597^1,2		--	113635715(+)	`TAATCA/GGGTCC`	2	--	int¹		0	--	--	--	--
rs16915497^1,2	C,F	--	113635778(+)	`TAACCG/ATGCAC`	2	--	int¹ ese³		4		NA EA	262
rs138907664^1,2		--	113635819(+)	`CTCCCA/GGACTT`	2	--	int¹		0	--	--	--	--
rs141693533^1,2		--	113635889(+)	`TGGTTA/GCTTGT`	2	--	int¹		0	--	--	--	--
rs144559100^1,2		--	113635901(+)	`ACAGCA/GAACTG`	2	--	int¹		0	--	--	--	--
rs1043128^1,2	C,F,A,H	--	113635929(-)	`TGTTGT/CCCAGG`	2	--	int¹		17		NS EA NA	2036
rs79950608^1,2	F	--	113635972(+)	`CCTATC/TGGGGT`	2	--	int¹		1		NA	120
rs117541680^1,2	F	--	113635987(+)	`CCTGGC/TGAATA`	2	--	int¹		1		EA	120
rs148051295^1,2		--	113636020(+)	`ACACAC/TTCAAC`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LPAR1 (113635543 - 113800981 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LPAR1
1 CNV: 7716
Human Gene Mutation Database (HGMD): LPAR1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LPAR1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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LPAR1 for disorders           About GeneDecksing

OMIM gene information: 602282    OMIM disorders: --

20/39 diseases for LPAR1 (see all 39):    About MalaCards

charcot-marie-tooth disease neuroblastoma malignant pleural mesothelioma tooth disease

systemic lupus erythematosus lupus erythematosus chronic lymphocytic leukemia lymphocytic leukemia

diphtheria rheumatoid arthritis colon cancer ovarian cancer

gastric cancer breast carcinoma osteosarcoma prostate cancer

breast cancer colon carcinoma pertussis carcinoma

10 Novoseek disease relationships for LPAR1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer	45.2	6	18461672 (2), 19001604 (1), 19116446 (1), 11353786 (1) (see all 5)
metastasis	30.2	9	18089805 (4), 11291053 (1), 10632375 (1), 19415462 (1) (see all 5)
cancer	28.5	16	19025891 (2), 15220934 (2), 14744855 (2), 9525886 (1) (see all 10)
breast carcinoma	26.3	1	18089805 (1)
osteosarcoma	17.7	1	10961347 (1)
tumors	11	8	19001604 (2), 18089805 (2), 19025891 (1), 11353786 (1) (see all 6)
breast cancer	9.21	4	10493533 (1), 18089805 (1), 16109476 (1), 19609003 (1)
colon cancer	5.64	2	15728708 (1), 12670925 (1)
gastric cancer	4.08	3	15530853 (1), 16353194 (1), 18701480 (1)
prostate cancer	0	4	16809448 (2), 19025891 (1), 17531530 (1)

Human Genome Epidemiology (HuGE) Navigator: LPAR1 (7 documents)

Export disorders for LPAR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LPAR1 gene, integrated from 9 sources (see all 144):
(articles sorted by number of sources associating them with LPAR1)

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world of online information

Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. (PubMed id 9070858)^{1, 2, 3, 9} An S....Goetzl E.J. (1997)
Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. (PubMed id 8922387)^{1, 3, 9} Hecht J.H....Chun J. (1996)
Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PubMed id 19306925)^{1, 2, 9} Aziziyeh A.I....Bhattacharya M. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Lysophosphatidic acid receptors. (PubMed id 11093753)^{1, 2} Contos J.J.A.... Chun J. (2000)
Lysophosphatidic acid: G-protein signalling and cellular responses. (PubMed id 9069262)^{1, 2} Moolenaar W.H.... Zondag G.C.M. (1997)
Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells. (PubMed id 16716145)^{1, 9} Waters C.M....Pyne N.J. (2006)
Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2. (PubMed id 18089805)^{1, 9} Horak C.E....Steeg P.S. (2007)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. (PubMed id 9804623)^{1, 9} An S....Goetzl E.J. (1998)
Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2. (PubMed id 18754873)^{1, 9} Yamada T....Sone S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1902	HGNC: 3166	AceView: EDG2	Ensembl:ENSG00000198121	euGenes: HUgn1902
ECgene: LPAR1	Kegg: 1902	H-InvDB: LPAR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LPAR1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LPAR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LPAR1 gene:
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GeneCards and IP:
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lysophosphatidic acid receptor 1

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LPAR1 Gene

lysophosphatidic acid receptor 1

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