Aliases for LPAR1 Gene
External Ids for LPAR1 Gene
Previous HGNC Symbols for LPAR1 Gene
Previous GeneCards Identifiers for LPAR1 Gene
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]
GeneCards Summary for LPAR1 Gene
LPAR1 (Lysophosphatidic Acid Receptor 1) is a Protein Coding gene. Diseases associated with LPAR1 include neuroblastoma. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is LPAR3.
UniProtKB/Swiss-Prot for LPAR1 Gene
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.