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Aliases for LPAR1 Gene

Aliases for LPAR1 Gene

  • Lysophosphatidic Acid Receptor 1 2 3 5
  • Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor, 2 2 3
  • Lysophosphatidic Acid Receptor Edg-2 3 4
  • LPA Receptor 1 3 4
  • LPA-1 3 4
  • EDG2 3 4
  • LPA1 3 4
  • Ventricular Zone Gene 1 3
  • Mrec1.3 3
  • Rec.1.3 3
  • Gpcr26 3
  • EDG-2 3
  • GPR26 3
  • Vzg-1 3
  • VZG1 3

External Ids for LPAR1 Gene

Previous HGNC Symbols for LPAR1 Gene

  • EDG2

Previous GeneCards Identifiers for LPAR1 Gene

  • GC09M112676
  • GC09M113635
  • GC09M083234

Summaries for LPAR1 Gene

Entrez Gene Summary for LPAR1 Gene

  • The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]

GeneCards Summary for LPAR1 Gene

LPAR1 (Lysophosphatidic Acid Receptor 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and phospholipid binding. An important paralog of this gene is LPAR3.

UniProtKB/Swiss-Prot for LPAR1 Gene

  • Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).

Gene Wiki entry for LPAR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR1 Gene

Genomics for LPAR1 Gene

Regulatory Elements for LPAR1 Gene

Promoters for LPAR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LPAR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPAR1 Gene

Chromosome:
9
Start:
110,873,261 bp from pter
End:
111,039,243 bp from pter
Size:
165,983 bases
Orientation:
Minus strand

Genomic View for LPAR1 Gene

Genes around LPAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR1 Gene

Proteins for LPAR1 Gene

  • Protein details for LPAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92633-LPAR1_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 1
    Protein Accession:
    Q92633
    Secondary Accessions:
    • B4DK36
    • O00656
    • O00722
    • P78351

    Protein attributes for LPAR1 Gene

    Size:
    364 amino acids
    Molecular mass:
    41109 Da
    Quaternary structure:
    • Interacts with RALA and ADRBK1 (PubMed:19306925). Interacts with GNAQ and GNA13. Interacts with CD14; the interaction is enhanced by exposure to bacterial lipopolysaccharide (LPS) (By similarity).

    Three dimensional structures from OCA and Proteopedia for LPAR1 Gene

    Alternative splice isoforms for LPAR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPAR1 Gene

Proteomics data for LPAR1 Gene at MOPED

Post-translational modifications for LPAR1 Gene

Other Protein References for LPAR1 Gene

Antibody Products

No data available for DME Specific Peptides for LPAR1 Gene

Domains & Families for LPAR1 Gene

Gene Families for LPAR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92633

UniProtKB/Swiss-Prot:

LPAR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR1: view

Function for LPAR1 Gene

Molecular function for LPAR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity).
genes like me logo Genes that share phenotypes with LPAR1: view

Animal Models for LPAR1 Gene

MGI Knock Outs for LPAR1:

Animal Model Products

CRISPR Products

miRNA for LPAR1 Gene

miRTarBase miRNAs that target LPAR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LPAR1 Gene

Localization for LPAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR1 Gene

Cell surface. Cell membrane; Multi-pass membrane protein. Endosome. Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment. {ECO:0000269 PubMed:19306925}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPAR1 Gene COMPARTMENTS Subcellular localization image for LPAR1 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 3
nucleus 3
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for LPAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LPAR1: view

Pathways & Interactions for LPAR1 Gene

genes like me logo Genes that share pathways with LPAR1: view

SIGNOR curated interactions for LPAR1 Gene

Activates:

Gene Ontology (GO) - Biological Process for LPAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 8922387
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS --
GO:0007202 activation of phospholipase C activity IDA 19306925
GO:0010942 positive regulation of cell death IEA --
GO:0021554 optic nerve development IEA --
genes like me logo Genes that share ontologies with LPAR1: view

Drugs & Compounds for LPAR1 Gene

(18) Drugs for LPAR1 Gene - From: IUPHAR, DGIdb, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-oleoyl-LPA Pharma Agonist 0
alkyl OMPT Pharma Agonist 0
AM966 Pharma Antagonist 0
Ki16425 Pharma Antagonist LPA receptor antagonist 0
VPC32183 Pharma Antagonist 0

(22) Additional Compounds for LPAR1 Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dioctanoy?aelglycerol?ae pyrophos?aephate
Antagonist
LPA(0:0/16:0)
  • 2-Hexadecanoyl-phosphatidic acid
  • 2-Palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • LPA(16:0)
  • Lysophosphatidic acid(0:0/16:0)
LPA(0:0/18:0)
  • 2-Octadecanoyl-phosphatidic acid
  • 2-Stearoyl-glycero-3-phosphate
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic acid(0:0/18:0)
LPA(0:0/18:1(9Z))
  • 2-(9Z-Octadecenoyl)-phosphatidic acid
  • 2-Oleoyl-glycero-3-phosphate
  • LPA(0:0/18:1)
  • LPA(0:0/18:1n9)
  • LPA(0:0/18:1w9)
LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-Octadecadienoyl)-phosphatidic acid
  • 2-Linoleoyl-glycero-3-phosphate
  • LPA(0:0/18:2)
  • LPA(0:0/18:2n6)
  • LPA(0:0/18:2w6)
genes like me logo Genes that share compounds with LPAR1: view

Drug Products

Transcripts for LPAR1 Gene

Unigene Clusters for LPAR1 Gene

Lysophosphatidic acid receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - - - - - - - -
SP6: - - - - - - -
SP7:
SP8: - - - - - - - - - -
SP9: - -

Relevant External Links for LPAR1 Gene

GeneLoc Exon Structure for
LPAR1
ECgene alternative splicing isoforms for
LPAR1

Expression for LPAR1 Gene

mRNA expression in normal human tissues for LPAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPAR1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.1), Brain - Putamen (basal ganglia) (x4.1), and Brain - Amygdala (x4.0).

Protein differential expression in normal tissues from HIPED for LPAR1 Gene

This gene is overexpressed in Testis (9.1), Skin (8.7), Frontal cortex (8.1), Spinal cord (7.3), and Urinary Bladder (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LPAR1 Gene



SOURCE GeneReport for Unigene cluster for LPAR1 Gene Hs.126667

mRNA Expression by UniProt/SwissProt for LPAR1 Gene

Q92633-LPAR1_HUMAN
Tissue specificity: Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes (PubMed:9070858). Detected in lung fibroblasts from bronchoalveolar fluid from patients with idiopathic pulmonary fibrosis (PubMed:18066075). Detected in bone marrow-derived mesenchymal stem cells (PubMed:19733258).
genes like me logo Genes that share expression patterns with LPAR1: view

Protein tissue co-expression partners for LPAR1 Gene

Primer Products

In Situ Assay Products

Orthologs for LPAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPAR1 35
  • 100 (n)
  • 100 (a)
LPAR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPAR1 36
  • 98 (a)
OneToOne
LPAR1 35
  • 91.67 (n)
  • 96.7 (a)
dog
(Canis familiaris)
Mammalia LPAR1 35
  • 94.05 (n)
  • 97.25 (a)
LPAR1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpar1 16
Lpar1 36
  • 97 (a)
OneToOne
Lpar1 35
  • 90.48 (n)
  • 97.25 (a)
oppossum
(Monodelphis domestica)
Mammalia LPAR1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPAR1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpar1 35
  • 89.56 (n)
  • 97.25 (a)
chicken
(Gallus gallus)
Aves LPAR1 36
  • 93 (a)
OneToOne
LPAR1 35
  • 83.76 (n)
  • 95.77 (a)
lizard
(Anolis carolinensis)
Reptilia LPAR1 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia edg2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar1 35
  • 77.66 (n)
  • 91.48 (a)
zebrafish
(Danio rerio)
Actinopterygii lpar1 36
  • 89 (a)
OneToOne
lpar1 35
  • 76.49 (n)
  • 89.31 (a)
Species with no ortholog for LPAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR1 Gene

ENSEMBL:
Gene Tree for LPAR1 (if available)
TreeFam:
Gene Tree for LPAR1 (if available)

Paralogs for LPAR1 Gene

Paralogs for LPAR1 Gene

(16) SIMAP similar genes for LPAR1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LPAR1: view

Variants for LPAR1 Gene

Sequence variations from dbSNP and Humsavar for LPAR1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs11542862 - 110,941,984(-) TGTCA(A/C/G)CCGCC reference, missense
rs15991 -- 110,874,099(-) GAAAT(A/G)TCATC utr-variant-3-prime
rs494605 -- 110,882,650(-) ATTAT(A/G)TATCT intron-variant
rs496475 -- 110,875,956(-) CATCA(A/C)TGTCT intron-variant
rs521339 -- 110,884,886(-) GAGAC(A/G)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPAR1 Gene

Variant ID Type Subtype PubMed ID
nsv527204 CNV Loss 19592680
esv2667259 CNV Deletion 23128226
nsv527998 CNV Gain 19592680
nsv526335 CNV Gain 19592680
esv2738930 CNV Deletion 23290073
nsv831689 CNV Gain 17160897
esv33480 CNV Gain+Loss 17666407

Variation tolerance for LPAR1 Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPAR1 Gene

HapMap Linkage Disequilibrium report
LPAR1
Human Gene Mutation Database (HGMD)
LPAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR1 Gene

Disorders for LPAR1 Gene

Relevant External Links for LPAR1

Genetic Association Database (GAD)
LPAR1
Human Genome Epidemiology (HuGE) Navigator
LPAR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPAR1

No disorders were found for LPAR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPAR1 Gene

Publications for LPAR1 Gene

  1. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. (PMID: 9070858) An S. … Goetzl E.J. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23 67
  2. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. (PMID: 8922387) Hecht J.H. … Chun J. (J. Cell Biol. 1996) 2 3 23
  3. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PMID: 19306925) Aziziyeh A.I. … Bhattacharya M. (Cell. Signal. 2009) 3 23
  4. Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections. (PMID: 18625619) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 23
  5. Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia. (PMID: 19025891) Zeng Y. … Wu X.X. (Prostate 2009) 3 23

Products for LPAR1 Gene

Sources for LPAR1 Gene

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