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LPAR1 Gene

protein-coding   GIFtS: 64
GCID: GC09M113635

Lysophosphatidic Acid Receptor 1

(Previous names: endothelial differentiation, lysophosphatidic acid G-protein-coupled...)
(Previous symbol: EDG2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysophosphatidic Acid Receptor 11 2     GPR262
EDG21 2 3 5     Gpcr262
LPA12 3 5     Mrec1.32
Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled
Receptor, 21 2
     edg-22
Lysophosphatidic Acid Receptor Edg-22 3     rec.1.32
LPA-12 3     Ventricular Zone Gene 12
LPA Receptor 12 3     vzg-12
VZG12 5     

External Ids:    HGNC: 31661   Entrez Gene: 19022   Ensembl: ENSG000001981217   OMIM: 6022825   UniProtKB: Q926333   

Export aliases for LPAR1 gene to outside databases

Previous GC identifers: GC09M112676 GC09M083234


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LPAR1 Gene:
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as
EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for
cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation,
smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion.
Two transcript variants encoding the same protein have been identified for this gene (provided by RefSeq, Jul
2008)

GeneCards Summary for LPAR1 Gene:
LPAR1 (lysophosphatidic acid receptor 1) is a protein-coding gene. Diseases associated with LPAR1 include neuroblastoma, and tooth disease. GO annotations related to this gene include PDZ domain binding and G-protein coupled receptor activity. An important paralog of this gene is CNR1.

UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633
Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled
to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC)
activity in a manner that is dependent on RALA activation

Gene Wiki entry for LPAR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LPAR1 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLPAR1 promoter sequence
   Search Chromatin IP Primers for LPAR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LPAR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.3   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q

LPAR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPAR1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M113635:  view genomic region     (about GC identifiers)

Start:
113,635,543 bp from pter      End:
113,800,981 bp from pter
Size:
165,439 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633 (See protein sequence)
Recommended Name: Lysophosphatidic acid receptor 1  
Size: 364 amino acids; 41109 Da
Subunit: Interacts with RALA and ADRBK1
Secondary accessions: O00656 O00722 P78351

Explore the universe of human proteins at neXtProt for LPAR1: NX_Q92633

Explore proteomics data for LPAR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn27, Asn35
  • Modification sites at PhosphoSitePlus

  • See LPAR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001392.2  NP_476500.1  

    ENSEMBL proteins: 
     ENSP00000363553   ENSP00000363552   ENSP00000351755   ENSP00000401810   ENSP00000440201  
     ENSP00000445697  
    Reactome Protein details: Q92633

    LPAR1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for LPAR1
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    Novus Biologicals LPAR1 Proteins
    Novus Biologicals LPAR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LPAR1

    LPAR1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LPAR1
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    LPAR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for LPAR1
    Cloud-Clone Corp. CLIAs for LPAR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LPAR: GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid

    IUPHAR Guide to PHARMACOLOGY protein family classification: LPA1 receptor
    Lysophospholipid (LPA) receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR004065 LPA_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR002277 LPA_rcpt_EDG2

    Graphical View of Domain Structure for InterPro Entry Q92633

    ProtoNet protein and cluster: Q92633

    2 Blocks protein domains:
    IPB002277 Lysophosphatidic acid receptor (EDG2) signature
    IPB004065 Lysophosphatidic acid receptor family signature


    UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633
    Similarity: Belongs to the G-protein coupled receptor 1 family


    LPAR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LPAR1_HUMAN, Q92633
    Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled
    to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC)
    activity in a manner that is dependent on RALA activation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0004930G-protein coupled receptor activity TAS8922387
    GO:0005515protein binding IPI19306925
    GO:0005543phospholipid binding IEA--
    GO:0030165PDZ domain binding IEA--
         
    LPAR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LPAR1:
     Increased gamma-H2AX phosphory  Synthetic lethal with paclitax 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lpar1):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  growth/size/body 
     homeostasis/metabolism  mortality/aging  nervous system  vision/eye 

    LPAR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lpar1tm1Jch for LPAR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LPAR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LPAR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LPAR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LPAR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LPAR1:
    hsa-mir-200c-3p (MIRT007343)

    Block miRNA regulation of human, mouse, rat LPAR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LPAR1 (see all 26):
    hsa-miR-3910 hsa-miR-217 hsa-miR-323-3p hsa-miR-892b hsa-miR-429 hsa-miR-4263 hsa-miR-374a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidLPAR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LPAR1
    Predesigned siRNA for gene silencing in human, mouse, rat LPAR1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LPAR1

    Clone
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    OriGene ORF clones in mouse, rat for LPAR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LPAR1 (NM_001401)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPAR1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPAR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LPAR1_HUMAN, Q92633: Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found
    predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9070858
    GO:0009986cell surface IDA19306925
    GO:0016021integral component of membrane ----

    LPAR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LPAR1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    5Ras signaling pathway
    Rap1 signaling pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LPAR1
        RhoA Pathway
    eNOS Signaling
    G12-G13 in Cellular Signaling
    Signaling in Gap Junctions

    3 BioSystems Pathways for LPAR1
        Myometrial Relaxation and Contraction Pathways
    LPA receptor mediated events
    Small Ligand GPCRs

    3 Reactome Pathways for LPAR1
        G alpha (q) signalling events
    Lysosphingolipid and LPA receptors
    G alpha (i) signalling events


    4 Kegg Pathways  (Kegg details for LPAR1):
        Rap1 signaling pathway
    Neuroactive ligand-receptor interaction
    PI3K-Akt signaling pathway
    Gap junction


    LPAR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LPAR1: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LPAR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LPAR1 (Q926333 ENSP000003517554) via UniProtKB, MINT, STRING, and/or I2D (see all 269)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGEF11O150853, ENSP000003571774I2D: score=1 STRING: ENSP00000357177
    ARHGEF12Q9NZN53, ENSP000003809424I2D: score=1 STRING: ENSP00000380942
    GNAI3P087543, ENSP000003588674I2D: score=1 STRING: ENSP00000358867
    SLC9A3R2Q155993, ENSP000004080054I2D: score=1 STRING: ENSP00000408005
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS8922387
    GO:0007202activation of phospholipase C activity TAS9804623
    GO:0007204positive regulation of cytosolic calcium ion concentration TAS9804623
    GO:0010942positive regulation of cell death ----

    LPAR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LPAR1

    10 HMDB Compounds for LPAR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    LPA(0:0/16:0)Lysophosphatidic acid(16:0) (see all 6)----
    LPA(0:0/18:0)2-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(0:0/18:1(9Z))LPA(18:1) (see all 10)----
    LPA(0:0/18:2(9Z,12Z))LPA(0:0/18:2n6) (see all 10)----
    LPA(16:0/0:0)Lysophosphatidic acid(16:0/0:0) (see all 14)----
    LPA(18:0/0:0)1-octadecanoyl-phosphatidic acid (see all 6)----
    LPA(18:0e/0:0)[(2R)-2-hydroxy-3-octadecoxy-propyl] dihydrogen phosphate;1-Octadecyl-sn-glycero-3-phosphate (see all 2)----
    LPA(18:1(9Z)/0:0)1-oleoyl-glycero-3-phosphate (see all 26)----
    LPA(18:2(9Z,12Z)/0:0)LPA(18:2w6/0:0) (see all 10)----
    LPA(P-16:0e/0:0)1-(1Z-hexadecenyl)-sn-glycero-3-phosphate;LysoPA(dm16:0e) ----

    7 IUPHAR Ligands for LPAR1 (LPA1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    AM966
    AntagonistAntagonist7.820649573
    VPC32183
    AntagonistAntagonist6.9615125924
    VPC12249
    AntagonistAntagonist6.8611723223
    2-oleoyl-LPA
    AgonistAgonist6.710922489
    Ki16425
    AntagonistAntagonist6.614500756
    alkyl OMPT
    AgonistAgonist6.116892372
    dioctanoy?aelglycerol?ae pyrophos?aephate
    AntagonistAntagonist5.1811562440

    Selected Novoseek inferred chemical compound relationships for LPAR1 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysophospholipid 84.2 2 9931453 (1), 11604399 (1)
    diacylglycerol pyrophosphate 75.6 1 15618220 (1)
    lysophosphatidylcholine 59 2 16627485 (1)
    phospholipid 56 3 11604399 (1), 15220934 (1), 15755723 (1)
    pertussis 50.7 2 9804623 (1)
    lipid 45.4 5 11723085 (1), 17156449 (1), 19081821 (1), 16210650 (1) (see all 5)
    vegf 24.6 2 20197381 (2)
    calcium 1.98 13 9804623 (8)
    arginine 0 2 15755723 (1), 18316373 (1)
    cisplatin 0 2 10632375 (2)



    LPAR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LPAR1 gene (2 alternative transcripts): 
    NM_001401.3  NM_057159.2  

    Unigene Cluster for LPAR1:

    Lysophosphatidic acid receptor 1
    Hs.126667  [show with all ESTs]
    Unigene Representative Sequence: BC036034
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374431(uc004bfb.3 uc004bfc.3 uc011lwn.2 uc010mub.3)
    ENST00000374430(uc004bfa.3 uc011lwm.2) ENST00000358883 ENST00000441240
    ENST00000538760 ENST00000541779(uc011lwo.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat LPAR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LPAR1 (see all 26):
    hsa-miR-3910 hsa-miR-217 hsa-miR-323-3p hsa-miR-892b hsa-miR-429 hsa-miR-4263 hsa-miR-374a hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidLPAR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LPAR1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LPAR1 (NM_001401)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPAR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LPAR1
    Primer
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    OriGene qPCR primer pairs and template standards for LPAR1
    OriGene qSTAR qPCR primer pairs in human, mouse for LPAR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LPAR1
      QuantiTect SYBR Green Assays in human, mouse, rat LPAR1
      QuantiFast Probe-based Assays in human, mouse, rat LPAR1

    Additional mRNA sequence: 

    AK022808.1 AK290287.1 AK296374.1 AK298590.1 AK299279.1 AY322546.1 BC030615.2 BC036034.1 
    BC073167.1 U78192.1 U80811.1 Y09479.1 

    11 DOTS entries:

    DT.97769991  DT.91735433  DT.91757548  DT.92026247  DT.121173151  DT.121173152  DT.121173154  DT.95135082 
    DT.121173114  DT.121173164  DT.91672717 

    Selected AceView cDNA sequences (see all 151):

    AI080501 F06566 NM_001401 AI161252 NM_057159 BQ898218 BQ028223 AI678309 
    AU120057 BQ446451 BQ019924 BE140638 AY322546 AI674417 AI168217 AK022808 
    AI272801 CA397755 CB241026 CB216093 BC036034 AA150119 CB132447 BU838473 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LPAR1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12
    SP1:                                                  -     -     -     -                                                   
    SP2:                                            -     -     -     -     -                       -                           
    SP3:                                                  -     -     -     -                       -                           
    SP4:                                                                                            -                           
    SP5:        -     -     -     -     -     -     -     -     -     -     -                       -                           


    ECgene alternative splicing isoforms for LPAR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    LPAR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGCAGTT
    LPAR1 Expression
    About this image


    LPAR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Neural Tube (Nervous System)
             Telencephalon
    LPAR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LPAR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126667

    UniProtKB/Swiss-Prot: LPAR1_HUMAN, Q92633
    Tissue specificity: Expressed in many adult organs, including brain, heart, colon, small intestine, placenta,
    prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung,
    thymus, or peripheral blood leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LPAR1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lpar11 , 5 lysophosphatidic acid receptor 11, 5 90.48(n)1
    97.25(a)1
      4 (32.20 cM)5
    147451  NM_172989.11  NP_766577.11 
     584352555 
    chicken
    (Gallus gallus)
    Aves LPAR11 lysophosphatidic acid receptor 1 83.76(n)
    95.77(a)
      427339  NM_001115082.1  NP_001108554.1 
    lizard
    (Anolis carolinensis)
    Reptilia LPAR16
    lysophosphatidic acid receptor 1
    92(a)
    1 ↔ 1
    GL343463.1(493973-556078)
    African clawed frog
    (Xenopus laevis)
    Amphibia edg2-A2 lysophosphatidic acid G-protein-coupled receptor 2 80.56(n)    AJ249844.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lpar11 lysophosphatidic acid receptor 1 76.49(n)
    89.31(a)
      368461  NM_001004502.2  NP_001004502.2 


    ENSEMBL Gene Tree for LPAR1 (if available)
    TreeFam Gene Tree for LPAR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LPAR1 gene
    CNR12  GPR122  LPAR22  S1PR12  CNR22  S1PR32  S1PR22  MC1R2  
    MC3R2  MC5R2  MC2R2  GPR32  MC4R2  S1PR42  GPR62  LPAR32  
    S1PR52  
    16 SIMAP similar genes for LPAR1 using alignment to 5 protein entries:     LPAR1_HUMAN (see all proteins):
    EDG2    LPAR2    LPAR3    EDG1    S1PR1    HTR5A
    S1PR3    S1PR2    MC4R    S1PR5    MC5R    MC3R
    S1PR4    CNR1    CHRM2    GPR3

    LPAR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LPAR1 (see all 3281)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826896811,2
    --83400721(+) ATAGAG/TATGTA 2 -- us2k10--------
    rs68331,2
    C,F,O,A,H--113635691(-) TGCACG/ATACTT 2 -- int1 ese327Minor allele frequency- A:0.43MN NA NS EA WA CSA 2862
    rs1450535971,2
    --113635715(+) TAATCA/GGGTCC 2 -- int10--------
    rs169154971,2
    C,F--113635778(+) TAACCG/ATGCAC 2 -- int1 ese34Minor allele frequency- A:0.02NA EA 262
    rs1389076641,2
    --113635819(+) CTCCCA/GGACTT 2 -- int10--------
    rs1416935331,2
    --113635889(+) TGGTTA/GCTTGT 2 -- int10--------
    rs1445591001,2
    --113635901(+) ACAGCA/GAACTG 2 -- int10--------
    rs10431281,2
    C,F,A,H--113635929(-) TGTTGT/CCCAGG 2 -- int117Minor allele frequency- C:0.13NS EA NA 2036
    rs799506081,2
    F--113635972(+) CCTATC/TGGGGT 2 -- int11Minor allele frequency- T:0.04NA 120
    rs1175416801,2
    C,F--113635987(+) CCTGGC/TGAATA 2 -- int11Minor allele frequency- T:0.07EA 120

    HapMap Linkage Disequilibrium report for LPAR1 (113635543 - 113800981 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LPAR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667259CNV Deletion23128226
    esv2738930CNV Deletion23290073
    nsv527204CNV Loss19592680
    nsv831689CNV Gain17160897
    nsv526335CNV Gain19592680
    nsv527998CNV Gain19592680
    esv33480CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): LPAR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LPAR1
    DNA2.0 Custom Variant and Variant Library Synthesis for LPAR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602282    OMIM disorders: --

    Selected diseases for LPAR1 (see all 35):    
    About MalaCards
    neuroblastoma    tooth disease    charcot-marie-tooth disease    diphtheria
    malignant pleural mesothelioma    keratoconus    osteosarcoma    endotheliitis
    ovarian cancer    pertussis    pulmonary function    thyroid cancer
    glioblastoma multiforme    osteoarthritis    astrocytoma    chronic lymphocytic leukemia
    type 1 diabetes    prostate cancer    thyroiditis    prostatitis


    LPAR1 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for LPAR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 45.2 6 18461672 (2), 19001604 (1), 19116446 (1), 11353786 (1) (see all 5)
    metastasis 30.2 9 18089805 (4), 11291053 (1), 10632375 (1), 19415462 (1) (see all 5)
    cancer 28.5 16 19025891 (2), 15220934 (2), 14744855 (2), 9525886 (1) (see all 10)
    breast carcinoma 26.3 1 18089805 (1)
    osteosarcoma 17.7 1 10961347 (1)
    tumors 11 8 19001604 (2), 18089805 (2), 19025891 (1), 11353786 (1) (see all 6)
    breast cancer 9.21 4 10493533 (1), 18089805 (1), 16109476 (1), 19609003 (1)
    colon cancer 5.64 2 15728708 (1), 12670925 (1)
    gastric cancer 4.08 3 15530853 (1), 16353194 (1), 18701480 (1)
    prostate cancer 0 4 16809448 (2), 19025891 (1), 17531530 (1)

    Genetic Association Database (GAD): LPAR1
    Human Genome Epidemiology (HuGE) Navigator: LPAR1 (7 documents)

    Export disorders for LPAR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LPAR1 gene, integrated from 10 sources (see all 155):
    (articles sorted by number of sources associating them with LPAR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. (PubMed id 9070858)1, 2, 3, 9 An S.... Goetzl E.J. (Biochem. Biophys. Res. Commun. 1997)
    2. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. (PubMed id 8922387)1, 3, 9 Hecht J.H....Chun J. (J. Cell Biol. 1996)
    3. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PubMed id 19306925)1, 2, 9 Aziziyeh A.I.... Bhattacharya M. (Cell. Signal. 2009)
    4. Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections. (PubMed id 18625619)1, 4, 9 Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
    5. Sequence variants in three loci influence monocyte counts and erythrocyte volume. (PubMed id 19853236)1, 4 Ferreira M.A....Boomsma D.I. (Am. J. Hum. Genet. 2009)
    6. A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese. (PubMed id 18325907)1, 4 Mototani H....Ikegawa S. (Hum. Mol. Genet. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Lysophosphatidic acid receptors. (PubMed id 11093753)1, 2 Contos J.J.A.... Chun J. (Mol. Pharmacol. 2000)
    9. Lysophosphatidic acid: G-protein signalling and cellular responses. (PubMed id 9069262)1, 2 Moolenaar W.H.... Zondag G.C.M. (Curr. Opin. Cell Biol. 1997)
    10. Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells. (PubMed id 16716145)1, 9 Waters C.M....Pyne N.J. (Biochem. J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1902 HGNC: 3166 AceView: EDG2 Ensembl:ENSG00000198121 euGenes: HUgn1902
    ECgene: LPAR1 Kegg: 1902 H-InvDB: LPAR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LPAR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LPAR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LPAR1 gene:
    Search GeneIP for patents involving LPAR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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