Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LPAR1 Gene

Aliases for LPAR1 Gene

  • Lysophosphatidic Acid Receptor 1 2 3
  • EDG2 3 4 6
  • LPA1 3 4 6
  • Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor, 2 2 3
  • Lysophosphatidic Acid Receptor Edg-2 3 4
  • LPA Receptor 1 3 4
  • LPA-1 3 4
  • VZG1 3 6
  • Ventricular Zone Gene 1 3
  • Mrec1.3 3
  • Rec.1.3 3
  • Gpcr26 3
  • GPR26 3
  • Edg-2 3
  • Vzg-1 3

External Ids for LPAR1 Gene

Previous HGNC Symbols for LPAR1 Gene

  • EDG2

Previous GeneCards Identifiers for LPAR1 Gene

  • GC09M112676
  • GC09M113635
  • GC09M083234

Summaries for LPAR1 Gene

Entrez Gene Summary for LPAR1 Gene

  • The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]

GeneCards Summary for LPAR1 Gene

LPAR1 (Lysophosphatidic Acid Receptor 1) is a Protein Coding gene. Diseases associated with LPAR1 include neuroblastoma. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and PDZ domain binding. An important paralog of this gene is LPAR3.

UniProtKB/Swiss-Prot for LPAR1 Gene

  • Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.

Gene Wiki entry for LPAR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAR1 Gene

Genomics for LPAR1 Gene

Regulatory Elements for LPAR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LPAR1 Gene

Start:
110,873,262 bp from pter
End:
111,039,243 bp from pter
Size:
165,982 bases
Orientation:
Minus strand

Genomic View for LPAR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAR1 Gene

Proteins for LPAR1 Gene

  • Protein details for LPAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92633-LPAR1_HUMAN
    Recommended name:
    Lysophosphatidic acid receptor 1
    Protein Accession:
    Q92633
    Secondary Accessions:
    • B4DK36
    • O00656
    • O00722
    • P78351

    Protein attributes for LPAR1 Gene

    Size:
    364 amino acids
    Molecular mass:
    41109 Da
    Quaternary structure:
    • Interacts with RALA and ADRBK1.

    Alternative splice isoforms for LPAR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LPAR1 Gene

Proteomics data for LPAR1 Gene at MOPED

Post-translational modifications for LPAR1 Gene

  • Glycosylation at Asn27 and Asn35
  • Modification sites at PhosphoSitePlus

Other Protein References for LPAR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LPAR1 Gene

Domains for LPAR1 Gene

Gene Families for LPAR1 Gene

HGNC:
  • LPAR :GPCR / Class A : Lysophospholipid receptors : Lysophosphatidic acid
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q92633

UniProtKB/Swiss-Prot:

LPAR1_HUMAN :
  • Q92633
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with LPAR1: view

Function for LPAR1 Gene

Molecular function for LPAR1 Gene

UniProtKB/Swiss-Prot Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.

Gene Ontology (GO) - Molecular Function for LPAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0004930 G-protein coupled receptor activity TAS 8922387
GO:0005515 protein binding IPI 19306925
GO:0005543 phospholipid binding IEA --
GO:0030165 PDZ domain binding IEA --
genes like me logo Genes that share ontologies with LPAR1: view
genes like me logo Genes that share phenotypes with LPAR1: view

Animal Models for LPAR1 Gene

MGI Knock Outs for LPAR1:

Animal Model Products

CRISPR Products

miRNA for LPAR1 Gene

miRTarBase miRNAs that target LPAR1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPAR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LPAR1 Gene

Localization for LPAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAR1 Gene

Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPAR1 Gene COMPARTMENTS Subcellular localization image for LPAR1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for LPAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9070858
GO:0009986 cell surface IDA 19306925
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with LPAR1: view

Pathways for LPAR1 Gene

genes like me logo Genes that share pathways with LPAR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LPAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8922387
GO:0007202 activation of phospholipase C activity TAS 9804623
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 9804623
GO:0010942 positive regulation of cell death --
genes like me logo Genes that share ontologies with LPAR1: view

Compounds for LPAR1 Gene

(5) Tocris Compounds for LPAR1 Gene

Compound Action Cas Number
GRI 977143 Selective LPA2 receptor non-lipid agonist [325850-81-5]
H2L 5765834 LPA1,3,5 antagonist [420841-84-5]
H2L5186303 Potent and selective LPA2 receptor antagonist [139262-76-3]
Ki 16425 LPA1 and LPA3 receptor antagonist [355025-24-0]
TC LPA5 4 LPA5 receptor antagonist [1393814-38-4]

(10) HMDB Compounds for LPAR1 Gene

Compound Synonyms Cas Number PubMed IDs
LPA(0:0/16:0)
  • Lysophosphatidic acid(16:0)
Not Available
LPA(0:0/18:0)
  • 2-octadecanoyl-phosphatidic acid
Not Available
LPA(0:0/18:1(9Z))
  • LPA(18:1)
Not Available
LPA(0:0/18:2(9Z,12Z))
  • LPA(0:0/18:2n6)
Not Available
LPA(16:0/0:0)
  • Lysophosphatidic acid(16:0/0:0)
Not Available

(7) IUPHAR Ligand for LPAR1 Gene

Ligand Type Action Affinity Pubmed IDs
2-oleoyl-LPA Agonist Agonist 8
alkyl OMPT Agonist Agonist 7.21
dioctanoy?aelglycerol?ae pyrophos?aephate Antagonist Antagonist 7
VPC32183 Antagonist Antagonist 6.76
VPC12249 Agonist Agonist 6.5
AM966 Antagonist Antagonist 5.7
Ki16425 Antagonist Antagonist 5.25

(11) Novoseek inferred chemical compound relationships for LPAR1 Gene

Compound -log(P) Hits PubMed IDs
lysophospholipid 84.2 2
diacylglycerol pyrophosphate 75.6 1
lysophosphatidylcholine 59 1
phospholipid 56 3
pertussis 50.7 1
genes like me logo Genes that share compounds with LPAR1: view

Transcripts for LPAR1 Gene

Unigene Clusters for LPAR1 Gene

Lysophosphatidic acid receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPAR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPAR1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - - - - - - - -
SP6: - - - - - - -
SP7:
SP8: - - - - - - - - - -
SP9: - -

Relevant External Links for LPAR1 Gene

GeneLoc Exon Structure for
LPAR1
ECgene alternative splicing isoforms for
LPAR1

Expression for LPAR1 Gene

mRNA expression in normal human tissues for LPAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPAR1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.1), Brain - Putamen (basal ganglia) (4.1), and Brain - Amygdala (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LPAR1 Gene

SOURCE GeneReport for Unigene cluster for LPAR1 Gene Hs.126667

mRNA Expression by UniProt/SwissProt for LPAR1 Gene

Q92633-LPAR1_HUMAN
Tissue specificity: Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes
genes like me logo Genes that share expressions with LPAR1: view

In Situ Assay Products

Orthologs for LPAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LPAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPAR1 35
  • 100 (n)
  • 100 (a)
LPAR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPAR1 35
  • 91.67 (n)
  • 96.7 (a)
LPAR1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPAR1 35
  • 94.05 (n)
  • 97.25 (a)
LPAR1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lpar1 35
  • 90.48 (n)
  • 97.25 (a)
Lpar1 16
Lpar1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPAR1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LPAR1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lpar1 35
  • 89.56 (n)
  • 97.25 (a)
chicken
(Gallus gallus)
Aves LPAR1 35
  • 83.76 (n)
  • 95.77 (a)
LPAR1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPAR1 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia edg2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lpar1 35
  • 77.66 (n)
  • 91.48 (a)
zebrafish
(Danio rerio)
Actinopterygii lpar1 35
  • 76.49 (n)
  • 89.31 (a)
lpar1 36
  • 89 (a)
OneToOne
Species with no ortholog for LPAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LPAR1 Gene

ENSEMBL:
Gene Tree for LPAR1 (if available)
TreeFam:
Gene Tree for LPAR1 (if available)

Paralogs for LPAR1 Gene

Selected SIMAP similar genes for LPAR1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LPAR1: view

Variants for LPAR1 Gene

Sequence variations from dbSNP and Humsavar for LPAR1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6833 -- 110,873,411(-) TGCAC(A/G)TACTT intron-variant, utr-variant-3-prime
rs13094 -- 110,874,073(+) CCTTT(G/T)CATGA utr-variant-3-prime
rs15991 -- 110,874,099(-) GAAAT(A/G)TCATC utr-variant-3-prime
rs488428 -- 110,886,172(-) tgctc(A/C/T)ggctg intron-variant
rs490058 -- 110,876,650(-) CAAGA(C/T)ATAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPAR1 Gene

Variant ID Type Subtype PubMed ID
nsv527204 CNV Loss 19592680
esv2667259 CNV Deletion 23128226
nsv527998 CNV Gain 19592680
nsv526335 CNV Gain 19592680
esv2738930 CNV Deletion 23290073
nsv831689 CNV Gain 17160897
esv33480 CNV Gain+Loss 17666407

Relevant External Links for LPAR1 Gene

HapMap Linkage Disequilibrium report
LPAR1
Human Gene Mutation Database (HGMD)
LPAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAR1 Gene

Disorders for LPAR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for LPAR1 Gene including...

Search for LPAR1 Gene in MalaCards »

(10) Novoseek inferred disease relationships for LPAR1 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 45.2 6
metastasis 30.2 8
cancer 28.5 13
breast carcinoma 26.3 1
osteosarcoma 17.7 1

Relevant External Links for LPAR1

Genetic Association Database (GAD)
LPAR1
Human Genome Epidemiology (HuGE) Navigator
LPAR1
genes like me logo Genes that share disorders with LPAR1: view

No data available for UniProtKB/Swiss-Prot for LPAR1 Gene

Publications for LPAR1 Gene

  1. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. (PMID: 9070858) An S. … Goetzl E.J. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. (PMID: 8922387) Hecht J.H. … Chun J. (J. Cell Biol. 1996) 2 3 23
  3. Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections. (PMID: 18625619) Dieguez-Gonzalez R. … Gonzalez A. (Ann. Rheum. Dis. 2009) 3 23 48
  4. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PMID: 19306925) Aziziyeh A.I. … Bhattacharya M. (Cell. Signal. 2009) 3 4 23
  5. Lysophosphatidic acid receptors. (PMID: 11093753) Contos J.J.A. … Chun J. (Mol. Pharmacol. 2000) 3 4

Products for LPAR1 Gene

Sources for LPAR1 Gene

Back to Top

Content