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Aliases for LPAL2 Gene

Aliases for LPAL2 Gene

  • Lipoprotein, Lp(A)-Like 2, Pseudogene 2 3 5
  • Apo(A)Rg-C 3 4
  • APOARGC 3 4
  • Apolipoprotein A-Related Gene C Protein 4
  • Apolipoprotein (A) Related Gene C 3
  • Lipoprotein, Lp(A)-Like 2 2
  • Apolipoprotein A-Like 2
  • Apo(A)-Like Protein 2 4
  • Lp(A)-Liker Protein 2 4
  • Apolipoprotein A-II 3
  • EC 63
  • EC 3.4.21 63
  • APOA2 3
  • APOAL 3

External Ids for LPAL2 Gene

Previous HGNC Symbols for LPAL2 Gene


Previous GeneCards Identifiers for LPAL2 Gene

  • GC06U990076
  • GC06M160721
  • GC06M160783
  • GC06M160858
  • GC06M160793
  • GC06M160807
  • GC06M160887
  • GC06M158362

Summaries for LPAL2 Gene

Entrez Gene Summary for LPAL2 Gene

  • Apolipoprotein(a) is the distinguishing protein moiety of lipoprotein(a), of which elevated plasma levels are correlated with an increased risk of atherosclerosis. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Consequently, this gene is considered to be a pseudogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

GeneCards Summary for LPAL2 Gene

LPAL2 (Lipoprotein, Lp(A)-Like 2, Pseudogene) is a Pseudogene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAL2 Gene

Genomics for LPAL2 Gene

Regulatory Elements for LPAL2 Gene

Enhancers for LPAL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LPAL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPAL2 Gene

160,453,428 bp from pter
160,511,124 bp from pter
57,697 bases
Minus strand

Genomic View for LPAL2 Gene

Genes around LPAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAL2 Gene

Proteins for LPAL2 Gene

  • Protein details for LPAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative apolipoprotein(a)-like protein 2
    Protein Accession:
    Secondary Accessions:
    • E1P5B4

    Protein attributes for LPAL2 Gene

    132 amino acids
    Molecular mass:
    14886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAL2 Gene

Proteomics data for LPAL2 Gene at MOPED

Selected DME Specific Peptides for LPAL2 Gene

Post-translational modifications for LPAL2 Gene

Domains & Families for LPAL2 Gene

Protein Domains for LPAL2 Gene


Suggested Antigen Peptide Sequences for LPAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The signal sequence and the kringle domain are highly similar to the apolipoprotein(a) precursor protein. This protein is however much shorter and does not contain any peptidase region.
  • The signal sequence and the kringle domain are highly similar to the apolipoprotein(a) precursor protein. This protein is however much shorter and does not contain any peptidase region.
  • Contains 1 kringle domain.
genes like me logo Genes that share domains with LPAL2: view

No data available for Gene Families for LPAL2 Gene

Function for LPAL2 Gene

Molecular function for LPAL2 Gene

GENATLAS Biochemistry:
lypoprotein Lp(a)-like 2

Enzyme Numbers (IUBMB) for LPAL2 Gene

genes like me logo Genes that share phenotypes with LPAL2: view

miRNA for LPAL2 Gene

miRTarBase miRNAs that target LPAL2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LPAL2 Gene

Localization for LPAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAL2 Gene


Gene Ontology (GO) - Cellular Components for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LPAL2: view

No data available for Subcellular locations from COMPARTMENTS for LPAL2 Gene

Pathways & Interactions for LPAL2 Gene

SuperPathways for LPAL2 Gene

No Data Available

Interacting Proteins for LPAL2 Gene

Selected Interacting proteins: Q16609-LPAL2_HUMAN for LPAL2 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for LPAL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LPAL2 Gene

Drugs & Compounds for LPAL2 Gene

(1) Additional Compounds for LPAL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LPAL2: view

Transcripts for LPAL2 Gene

mRNA/cDNA for LPAL2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LPAL2 Gene

Lipoprotein, Lp(a)-like 2, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPAL2 Gene

No ASD Table

Relevant External Links for LPAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LPAL2 Gene

mRNA expression in normal human tissues for LPAL2 Gene

mRNA differential expression in normal tissues according to GTEx for LPAL2 Gene

This gene is overexpressed in Liver (x24.2).

Protein differential expression in normal tissues from HIPED for LPAL2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LPAL2 Gene

SOURCE GeneReport for Unigene cluster for LPAL2 Gene Hs.654503

mRNA Expression by UniProt/SwissProt for LPAL2 Gene

Tissue specificity: Expressed in liver but not in other tissues tested.
genes like me logo Genes that share expression patterns with LPAL2: view

Protein tissue co-expression partners for LPAL2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LPAL2 Gene

Orthologs for LPAL2 Gene

Evolution for LPAL2 Gene

Gene Tree for LPAL2 (if available)
Gene Tree for LPAL2 (if available)

No data available for Orthologs for LPAL2 Gene

Paralogs for LPAL2 Gene

(14) SIMAP similar genes for LPAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LPAL2: view

No data available for Paralogs for LPAL2 Gene

Variants for LPAL2 Gene

Sequence variations from dbSNP and Humsavar for LPAL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_051100 -
rs1112073 -- 160,469,810(+) GCCAG(A/T)GGCAA intron-variant
rs1159259 -- 160,476,288(-) CGGGC(C/T)GGTAC intron-variant
rs1510224 -- 160,473,846(-) gagaa(A/G)tagat intron-variant
rs6902316 -- 160,472,135(+) atcac(A/G/T)ttaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPAL2 Gene

Variant ID Type Subtype PubMed ID
dgv2024e1 CNV Complex 17122850
esv35098 CNV Gain 17911159
nsv818463 CNV Gain 17921354
dgv7013n71 CNV Gain 21882294
nsv886810 CNV Gain 21882294
essv6642 CNV CNV 17122850
nsv886813 CNV Loss 21882294
esv6519 CNV Loss 19470904
esv5050 CNV Duplication 18987735
esv2733055 CNV Deletion 23290073
esv2663488 CNV Deletion 23128226
nsv525990 CNV Loss 19592680
nsv5566 CNV Insertion 18451855
esv8214 CNV Loss 19470904
nsv349217 CNV Insertion 16902084
esv1960835 CNV Deletion 18987734

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for LPAL2 Gene

Disorders for LPAL2 Gene

Relevant External Links for LPAL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LPAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPAL2 Gene

Publications for LPAL2 Gene

  1. Loss of a splice donor site at a 'skipped exon' in a gene homologous to apolipoprotein(a) leads to an mRNA encoding a protein consisting of a single kringle domain. (PMID: 7749817) Byrne C.D. … Lawn R.M. (Arterioscler. Thromb. Vasc. Biol. 1995) 2 3 4 67
  2. 5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family. (PMID: 7679504) Wade D.P. … Lawn R.M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3
  3. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. (PMID: 24262325) Dichgans M. … . (Stroke 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes. (PMID: 21900290) Qi Q. … Qi L. (Eur. Heart J. 2012) 3

Products for LPAL2 Gene

Sources for LPAL2 Gene