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Aliases for LPAL2 Gene

Aliases for LPAL2 Gene

  • Lipoprotein(A) Like 2, Pseudogene 2 3 5
  • Lipoprotein, Lp(A)-Like 2, Pseudogene 2 3
  • Apo(A)Rg-C 3 4
  • APOARGC 3 4
  • Apolipoprotein A-Related Gene C Protein 4
  • Apolipoprotein (A) Related Gene C 3
  • Lipoprotein, Lp(A)-Like 2 2
  • Apolipoprotein A-Like 2
  • Apo(A)-Like Protein 2 4
  • Lp(A)-Liker Protein 2 4
  • Apolipoprotein A-II 3
  • EC 3.4.21.7 61
  • EC 3.4.21 61
  • APOA2 3
  • APOAL 3

External Ids for LPAL2 Gene

Previous HGNC Symbols for LPAL2 Gene

  • APOAL

Previous GeneCards Identifiers for LPAL2 Gene

  • GC06U990076
  • GC06M160721
  • GC06M160783
  • GC06M160858
  • GC06M160793
  • GC06M160807
  • GC06M160887
  • GC06M158362

Summaries for LPAL2 Gene

Entrez Gene Summary for LPAL2 Gene

  • Apolipoprotein(a) is the distinguishing protein moiety of lipoprotein(a), of which elevated plasma levels are correlated with an increased risk of atherosclerosis. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Consequently, this gene is considered to be a pseudogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

GeneCards Summary for LPAL2 Gene

LPAL2 (Lipoprotein(A) Like 2, Pseudogene) is a Pseudogene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAL2 Gene

Genomics for LPAL2 Gene

Regulatory Elements for LPAL2 Gene

Enhancers for LPAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F160519 1.1 Ensembl ENCODE 6.7 -9.1 -9096 2.0 ATF1 ZNF48 ZNF2 YY1 ELK1 ZNF143 SP3 YY2 REST KAT8 LPAL2 LPA
GH06F160160 1 ENCODE 5.2 +350.6 350551 0.2 ELF3 CTCF LEF1 CEBPG RAD21 RARA GATAD2A TFE3 NFIA RNF2 LPAL2 ENSG00000216516 SLC22A1
GH06F160460 0.8 Ensembl ENCODE 4.4 +49.3 49324 3.6 SOX13 ZNF175 EBF1 ZNF316 EED ETV6 CREM MAFK SOX5 CBFB SLC22A3 LPAL2 PIR50129
GH06F160534 0.9 Ensembl ENCODE 0.3 -23.2 -23201 0.6 ELF3 ARID4B ZNF48 DNMT3B ZNF2 RAD21 GATA2 SCRT2 ZNF143 MIXL1 SLC22A3 LPAL2 LPA
GH06F160456 0.2 ENCODE 0.2 +54.4 54431 0.0 ZBTB8A ZNF623 ZNF101 SLC22A3 SNORA29 TCP1 PIR50129 LPAL2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LPAL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LPAL2 Gene

Chromosome:
6
Start:
160,453,428 bp from pter
End:
160,511,124 bp from pter
Size:
57,697 bases
Orientation:
Minus strand

Genomic View for LPAL2 Gene

Genes around LPAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAL2 Gene

Proteins for LPAL2 Gene

  • Protein details for LPAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16609-LPAL2_HUMAN
    Recommended name:
    Putative apolipoprotein(a)-like protein 2
    Protein Accession:
    Q16609
    Secondary Accessions:
    • E1P5B4

    Protein attributes for LPAL2 Gene

    Size:
    132 amino acids
    Molecular mass:
    14886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAL2 Gene

Selected DME Specific Peptides for LPAL2 Gene

Q16609:
  • VRWEYCNL
  • PWCYTTDP
  • NYCRNPD
  • GQSYRGT
  • WSSMTPHQH

Post-translational modifications for LPAL2 Gene

Domains & Families for LPAL2 Gene

Protein Domains for LPAL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LPAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16609

UniProtKB/Swiss-Prot:

LPAL2_HUMAN :
  • The signal sequence and the kringle domain are highly similar to the apolipoprotein(a) precursor protein. This protein is however much shorter and does not contain any peptidase region.
Domain:
  • The signal sequence and the kringle domain are highly similar to the apolipoprotein(a) precursor protein. This protein is however much shorter and does not contain any peptidase region.
  • Contains 1 kringle domain.
genes like me logo Genes that share domains with LPAL2: view

No data available for Gene Families for LPAL2 Gene

Function for LPAL2 Gene

Molecular function for LPAL2 Gene

GENATLAS Biochemistry:
lypoprotein Lp(a)-like 2

Enzyme Numbers (IUBMB) for LPAL2 Gene

Gene Ontology (GO) - Molecular Function for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LPAL2: view
genes like me logo Genes that share phenotypes with LPAL2: view

Animal Model Products

miRNA for LPAL2 Gene

miRTarBase miRNAs that target LPAL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LPAL2 Gene

Localization for LPAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAL2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LPAL2: view

No data available for Subcellular locations from COMPARTMENTS for LPAL2 Gene

Pathways & Interactions for LPAL2 Gene

SuperPathways for LPAL2 Gene

No Data Available

Interacting Proteins for LPAL2 Gene

Selected Interacting proteins: Q16609-LPAL2_HUMAN for LPAL2 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LPAL2: view

No data available for Pathways by source and SIGNOR curated interactions for LPAL2 Gene

Drugs & Compounds for LPAL2 Gene

(1) Additional Compounds for LPAL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LPAL2: view

Transcripts for LPAL2 Gene

mRNA/cDNA for LPAL2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LPAL2 Gene

Lipoprotein, Lp(a)-like 2, pseudogene:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPAL2 Gene

No ASD Table

Relevant External Links for LPAL2 Gene

GeneLoc Exon Structure for
LPAL2
ECgene alternative splicing isoforms for
LPAL2

Expression for LPAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LPAL2 Gene

mRNA differential expression in normal tissues according to GTEx for LPAL2 Gene

This gene is overexpressed in Liver (x24.2).

Protein differential expression in normal tissues from HIPED for LPAL2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LPAL2 Gene



Protein tissue co-expression partners for LPAL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LPAL2 Gene:

LPAL2

SOURCE GeneReport for Unigene cluster for LPAL2 Gene:

Hs.654503

mRNA Expression by UniProt/SwissProt for LPAL2 Gene:

Q16609-LPAL2_HUMAN
Tissue specificity: Expressed in liver but not in other tissues tested.
genes like me logo Genes that share expression patterns with LPAL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LPAL2 Gene

Orthologs for LPAL2 Gene

Evolution for LPAL2 Gene

ENSEMBL:
Gene Tree for LPAL2 (if available)
TreeFam:
Gene Tree for LPAL2 (if available)

No data available for Orthologs for LPAL2 Gene

Paralogs for LPAL2 Gene

(14) SIMAP similar genes for LPAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LPAL2: view

No data available for Paralogs for LPAL2 Gene

Variants for LPAL2 Gene

Sequence variations from dbSNP and Humsavar for LPAL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1009324 -- 160,484,383(+) TTGCC(A/G)CAAGC intron-variant
rs10223445 -- 160,466,264(+) ggatc(A/G)gGACC downstream-variant-500B
rs10562461 -- 160,509,059(+) CATCT(-/AC)ACACA intron-variant
rs10581539 -- 160,509,059(+) CATCT(-/ACAC)ACACA intron-variant
rs10636061 -- 160,467,924(+) TTTTT(-/TTT)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPAL2 Gene

Variant ID Type Subtype PubMed ID
esv1960835 CNV deletion 18987734
esv2663488 CNV deletion 23128226
esv2733055 CNV deletion 23290073
esv2759484 CNV gain+loss 17122850
esv35098 CNV gain 17911159
esv3611436 CNV gain 21293372
esv3611437 CNV loss 21293372
esv3611438 CNV gain 21293372
esv5050 OTHER sequence alteration 18987735
esv6519 CNV loss 19470904
esv8214 CNV loss 19470904
nsv1026543 CNV gain 25217958
nsv349217 CNV insertion 16902084
nsv525990 CNV loss 19592680
nsv5566 CNV insertion 18451855
nsv818463 CNV gain 17921354
nsv965781 CNV duplication 23825009
nsv969463 CNV duplication 23825009
nsv970183 CNV duplication 23825009
nsv970184 CNV duplication 23825009
nsv970185 CNV duplication 23825009
nsv970186 CNV duplication 23825009

Relevant External Links for LPAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LPAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for LPAL2 Gene

Disorders for LPAL2 Gene

Relevant External Links for LPAL2

Genetic Association Database (GAD)
LPAL2
Human Genome Epidemiology (HuGE) Navigator
LPAL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPAL2

No disorders were found for LPAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LPAL2 Gene

Publications for LPAL2 Gene

  1. Loss of a splice donor site at a 'skipped exon' in a gene homologous to apolipoprotein(a) leads to an mRNA encoding a protein consisting of a single kringle domain. (PMID: 7749817) Byrne C.D. … Lawn R.M. (Arterioscler. Thromb. Vasc. Biol. 1995) 2 3 4 64
  2. Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes. (PMID: 21900290) Qi Q. … Qi L. (Eur. Heart J. 2012) 3 46 64
  3. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. (PMID: 19198611) TrAcgouAt D.A. … Samani N.J. (Nat. Genet. 2009) 3 46 64
  4. 5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family. (PMID: 7679504) Wade D.P. … Lawn R.M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 64
  5. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. (PMID: 24262325) Dichgans M. … . (Stroke 2014) 3 64

Products for LPAL2 Gene

Sources for LPAL2 Gene

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