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Aliases for LPAL2 Gene

Aliases for LPAL2 Gene

  • Lipoprotein, Lp(A)-Like 2, Pseudogene 2 3
  • APOARGC 3 4 6
  • Apo(A)Rg-C 3 4
  • Apolipoprotein A-Related Gene C Protein 4
  • Apolipoprotein (A) Related Gene C 3
  • Lipoprotein, Lp(A)-Like 2 2
  • Apolipoprotein A-Like 2
  • Apo(A)-Like Protein 2 4
  • Lp(A)-Liker Protein 2 4
  • Apolipoprotein A-II 3
  • EC 3.4.21.7 63
  • EC 3.4.21 63
  • APOA2 3
  • APOAL 3

External Ids for LPAL2 Gene

Previous HGNC Symbols for LPAL2 Gene

  • APOAL

Previous GeneCards Identifiers for LPAL2 Gene

  • GC06U990076
  • GC06M160721
  • GC06M160783
  • GC06M160858
  • GC06M160793
  • GC06M160807
  • GC06M160887
  • GC06M158362

Summaries for LPAL2 Gene

Entrez Gene Summary for LPAL2 Gene

  • Apolipoprotein(a) is the distinguishing protein moiety of lipoprotein(a), of which elevated plasma levels are correlated with an increased risk of atherosclerosis. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Consequently, this gene is considered to be a pseudogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

GeneCards Summary for LPAL2 Gene

LPAL2 (Lipoprotein, Lp(A)-Like 2, Pseudogene) is a Pseudogene. Among its related pathways are Signaling by GPCR and Disease.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPAL2 Gene

Genomics for LPAL2 Gene

Genomic Location for LPAL2 Gene

Start:
160,453,428 bp from pter
End:
160,511,124 bp from pter
Size:
57,697 bases
Orientation:
Minus strand

Genomic View for LPAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LPAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPAL2 Gene

Proteins for LPAL2 Gene

  • Protein details for LPAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16609-LPAL2_HUMAN
    Recommended name:
    Putative apolipoprotein(a)-like protein 2
    Protein Accession:
    Q16609
    Secondary Accessions:
    • E1P5B4

    Protein attributes for LPAL2 Gene

    Size:
    132 amino acids
    Molecular mass:
    14886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LPAL2 Gene

Proteomics data for LPAL2 Gene at MOPED

Selected DME Specific Peptides for LPAL2 Gene

Post-translational modifications for LPAL2 Gene

Domains for LPAL2 Gene

Protein Domains for LPAL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LPAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16609

UniProtKB/Swiss-Prot:

LPAL2_HUMAN :
  • Q16609
Domain:
  • The signal sequence and the kringle domain are highly similar to the apolipoprotein(a) precursor protein. This protein is however much shorter and does not contain any peptidase region
  • Contains 1 kringle domain.
genes like me logo Genes that share domains with LPAL2: view

No data available for Gene Families for LPAL2 Gene

Function for LPAL2 Gene

Molecular function for LPAL2 Gene

GENATLAS Biochemistry:
lypoprotein Lp(a)-like 2

Enzyme Numbers (IUBMB) for LPAL2 Gene

Gene Ontology (GO) - Molecular Function for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with LPAL2: view

miRNA for LPAL2 Gene

miRTarBase miRNAs that target LPAL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPAL2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LPAL2 Gene

Localization for LPAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LPAL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPAL2 Gene COMPARTMENTS Subcellular localization image for LPAL2 gene
Compartment Confidence
extracellular 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with LPAL2: view

Pathways for LPAL2 Gene

genes like me logo Genes that share pathways with LPAL2: view

Pathways by source for LPAL2 Gene

Interacting Proteins for LPAL2 Gene

Selected Interacting proteins: Q16609-LPAL2_HUMAN for LPAL2 Gene via UniProtKB

Symbol External ID(s) Details
VAC14

Gene Ontology (GO) - Biological Process for LPAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LPAL2: view

Compounds for LPAL2 Gene

(1) Novoseek inferred chemical compound relationships for LPAL2 Gene

Compound -log(P) Hits PubMed IDs
lipid 12.1 3
genes like me logo Genes that share compounds with LPAL2: view

Transcripts for LPAL2 Gene

mRNA/cDNA for LPAL2 Gene

(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LPAL2 Gene

Lipoprotein, Lp(a)-like 2, pseudogene:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LPAL2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LPAL2 Gene

No ASD Table

Relevant External Links for LPAL2 Gene

GeneLoc Exon Structure for
LPAL2
ECgene alternative splicing isoforms for
LPAL2

Expression for LPAL2 Gene

mRNA expression in normal human tissues for LPAL2 Gene

mRNA differential expression in normal tissues according to GTEx for LPAL2 Gene

This gene is overexpressed in Liver (24.2).

Protein differential expression in normal tissues for LPAL2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for LPAL2 Gene

SOURCE GeneReport for Unigene cluster for LPAL2 Gene Hs.654503

mRNA Expression by UniProt/SwissProt for LPAL2 Gene

Q16609-LPAL2_HUMAN
Tissue specificity: Expressed in liver but not in other tissues tested.
genes like me logo Genes that share expressions with LPAL2: view

Expression partners for LPAL2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LPAL2 Gene

Orthologs for LPAL2 Gene

Evolution for LPAL2 Gene

ENSEMBL:
Gene Tree for LPAL2 (if available)
TreeFam:
Gene Tree for LPAL2 (if available)

No data available for Orthologs for LPAL2 Gene

Paralogs for LPAL2 Gene

Selected SIMAP similar genes for LPAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LPAL2: view

No data available for Paralogs for LPAL2 Gene

Variants for LPAL2 Gene

Sequence variations from dbSNP and Humsavar for LPAL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1009324 -- 160,484,383(+) TTGCC(A/G)CAAGC intron-variant
rs1112073 -- 160,469,810(+) GCCAG(A/T)GGCAA intron-variant
rs1159259 -- 160,476,288(-) CGGGC(C/T)GGTAC intron-variant
rs1355275 -- 160,476,488(-) acaca(A/C)acaca intron-variant
rs1510224 -- 160,473,846(-) gagaa(A/G)tagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LPAL2 Gene

Variant ID Type Subtype PubMed ID
dgv2024e1 CNV Complex 17122850
esv35098 CNV Gain 17911159
nsv818463 CNV Gain 17921354
dgv7013n71 CNV Gain 21882294
nsv886810 CNV Gain 21882294
essv6642 CNV CNV 17122850
nsv886813 CNV Loss 21882294
esv6519 CNV Loss 19470904
esv5050 CNV Duplication 18987735
esv2733055 CNV Deletion 23290073
esv2663488 CNV Deletion 23128226
nsv525990 CNV Loss 19592680
nsv5566 CNV Insertion 18451855
esv8214 CNV Loss 19470904
nsv349217 CNV Insertion 16902084
esv1960835 CNV Deletion 18987734

Relevant External Links for LPAL2 Gene

HapMap Linkage Disequilibrium report
LPAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LPAL2 Gene

Disorders for LPAL2 Gene

Relevant External Links for LPAL2

Genetic Association Database (GAD)
LPAL2
Human Genome Epidemiology (HuGE) Navigator
LPAL2

No disorders were found for LPAL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for LPAL2 Gene

Publications for LPAL2 Gene

  1. Loss of a splice donor site at a 'skipped exon' in a gene homologous to apolipoprotein(a) leads to an mRNA encoding a protein consisting of a single kringle domain. (PMID: 7749817) Byrne C.D. … Lawn R.M. (Arterioscler. Thromb. Vasc. Biol. 1995) 2 3 4
  2. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. (PMID: 19198611) TrAcgouAt D.A. … Samani N.J. (Nat. Genet. 2009) 3 48
  3. Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes. (PMID: 21900290) Qi Q. … Qi L. (Eur. Heart J. 2012) 3 48
  4. 5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family. (PMID: 7679504) Wade D.P. … Lawn R.M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3
  5. Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study. (PMID: 23036009) Lv X. … Qiu J. (Lipids Health Dis 2012) 3

Products for LPAL2 Gene

Sources for LPAL2 Gene

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