Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LPA Gene

protein-coding GIFtS: 62
GCID: GC06M160952

lipoprotein, Lp(a)

(Previous symbol: LP)

Explore 104 diseases affiliated with
LPA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lipoprotein, Lp(A)¹ ²		Lp(A)¹
LP¹ ²		Apo(A)¹
AK38²		EC 3.4.21.-³
APOA²		Lp(A)¹
Antiangiogenic AK38 Protein²		EC 3.4.21⁸
Apo(A)¹		EC 3.4.21.7⁸
Apolipoprotein(A)¹

External Ids:	HGNC: 6667¹	Entrez Gene: 4018²	Ensembl: ENSG00000198670⁷	OMIM: 152200⁵	UniProtKB: P08519³

Export aliases for LPA gene to outside databases

Previous GC identifers: GC06U990074 GC06M160826 GC06M160707 GC06M160861 GC06M160844 GC06M160872 GC06M158427

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LPA:

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator

I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting

in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein

are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type

domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in

the reference genome sequence. (provided by RefSeq, Dec 2009)

UniProtKB/Swiss-Prot: APOA_HUMAN, P08519

Function: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of

autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330

Gene Wiki entry for LPA (Lipoprotein(a))

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LPA gene promoter:
CREB PPAR-gamma1 ATF-2 deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LPA promoter sequence

Search SABiosciences Chromatin IP Primers for LPA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q26 Ensembl cytogenetic band: 6q26 HGNC cytogenetic band: 6q25-q26

LPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPA gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M160952: view genomic region (about GC identifiers)

Start:	160,952,515 bp from pter	End:	161,087,407 bp from pter
Size:	134,893 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APOA_HUMAN, P08519 (See protein sequence)

Recommended Name: Apolipoprotein(a) precursor

Size: 4548 amino acids; 501319 Da

Subunit: Disulfide-linked to apo-B100. Binds to fibronectin and decorin

Miscellaneous: Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a).

Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may

limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the

atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding

6 PDB 3D structures from and Proteopedia for LPA:

1I71 (3D)

1JFN (3D)

1KIV (3D)

2FEB (3D)

3KIV (3D)

4KIV (3D)

Secondary accessions: Q5VTD7 Q9UD88

Explore the universe of human proteins at neXtProt for LPA: NX_P08519

Post-translational modifications:

N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated

state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure,

NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08519

4/36 DME Specific Peptides for LPA (P08519) (see all 36)

KLFDYCD

CYITGWG

PHWHQRT

CRNPDGD

LPA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005568.2

ENSEMBL proteins:

ENSP00000321334 ENSP00000395608

Reactome Protein details: P08519
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for LPA
	GenScript Custom Purified and Recombinant Proteins Services for LPA
	Novus Biologicals LPA Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0034358	plasma lipoprotein particle	IDA	2531657

LPA for ontologies About GeneDecksing

LPA Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LPA
	Browse R&D Systems for Antibodies
	OriGene Antibodies: LPA OriGene Custom Antibody Services for LPA
	GenScript Superior Antibodies for LPA
	Novus Biologicals LPA Antibodies
	Abcam antibodies for LPA
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for LPA

Assay Products for LPA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LPA
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LPA for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR001314 Peptidase_S1A

IPR018056 Kringle_CS

IPR001254 Peptidase_S1

IPR018114 Peptidase_S1_AS

IPR000001 Kringle

Graphical View of Domain Structure for InterPro Entry P08519

ProtoNet protein and cluster: P08519

3 Blocks protein families:

IPB000001 Kringle

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: APOA_HUMAN, P08519

Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily

Similarity: Contains 38 kringle domains

Similarity: Contains 1 peptidase S1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APOA_HUMAN, P08519

Function: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of

autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330

Genatlas biochemistry entry for LPA:

lipoprotein,Lp(a),tightly linked (50k6) and highly homologous to PLG,susceptibility gene for IDDM8

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.7² EC 3.4.21.-¹

miRNA Products:		OriGene 3'-UTR Clone: LPA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LPA
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LPA
		SwitchGear 3'UTR luciferase reporter plasmid: LPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LPA OriGene shRNA RFP: LPA OriGene siRNA: LPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LPA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LPA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LPA OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LPA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): LPA (NM_001401)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPA
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LPA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LPA
		Search LifeMap BioReagents cell lines for LPA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPA

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001968	fibronectin binding	IPI	2531657
GO:0004252	serine-type endopeptidase activity	IDA	2531657
GO:0004866	endopeptidase inhibitor activity	TAS	8047165
GO:0008201	heparin binding	NAS	2531657
GO:0034185	apolipoprotein binding	IPI	9269765

LPA for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for LPA:

Increased Salmonella enterica

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lipoprotein metabolism

Lipoprotein metabolism

1.00

Lipid digestion, mobilization, and transport

0.56

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Selected targets of HNF1

Selected targets of HNF1

1.00

amb2 Integrin signaling

amb2 Integrin signaling

1.00

LDL-mediated lipid transport

LDL-mediated lipid transport

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for LPA

Selected targets of HNF1

1 BioSystems Pathway for LPA

amb2 Integrin signaling

5 Reactome Pathways for LPA

	Lipid digestion, mobilization, and transport
	Metabolism
	Lipoprotein metabolism
	LDL-mediated lipid transport
	Metabolism of lipids and lipoproteins

LPA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LPA

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/17 Interacting proteins for LPA (P08519³ ENSP00000321334⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FGB	P02675³, ENSP00000306099⁴	I2D: score=2 STRING: ENSP00000306099
FN1	P02751³, ENSP00000346839⁴	I2D: score=2 STRING: ENSP00000346839
FBLN5	Q9UBX5³, ENSP00000345008⁴	I2D: score=1 STRING: ENSP00000345008
CANX	P27824³, ENSP00000247461⁴	I2D: score=2 STRING: ENSP00000247461
APOH	P02749³, ENSP00000205948⁴	I2D: score=2 STRING: ENSP00000205948

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0006629	lipid metabolic process	TAS	--
GO:0006869	lipid transport	IEA	--
GO:0006898	receptor-mediated endocytosis	TAS	--
GO:0008015	blood circulation	TAS	8047165

LPA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LPA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LPA

1 DrugBank Compound for LPA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Aminocaproic Acid	6-aminohexanoic acid (see all 7)	60-32-2	target	other	17139284 17016423 15287725

10/68 Novoseek chemical compound relationships for LPA gene (see all 68) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cholesterol	83.8	281	1531990 (3), 16092061 (3), 16375584 (3), 8461626 (2) (see all 99)
lipid	75.3	123	9029226 (4), 9542772 (2), 12380908 (2), 11165958 (2) (see all 99)
fibrinogen	59	41	17669712 (3), 16125536 (3), 10102473 (2), 9169895 (2) (see all 28)
cholesterol ester	54.1	3	12679198 (1), 18187430 (1), 17211855 (1)
homocysteine	48.1	25	14977830 (3), 16125536 (3), 16103723 (1), 12297895 (1) (see all 16)
fenofibrate	48	3	12017210 (1), 1588829 (1)
mspi	47.4	2	1968792 (1)
epsilon aminocaproic acid	46.1	8	8845377 (2), 1838924 (2), 9837867 (1)
lovastatin	45.3	5	8026027 (1), 7654731 (1), 7981178 (1), 10532693 (1)
gemfibrozil	31.6	1	9006811 (1)

Search CenterWatch for drugs/clinical trials and news about LPA / APOA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LPA gene:

NM_005577.2

Unigene Cluster for LPA:

Lipoprotein, Lp(a)

Hs.520120 [show with all ESTs]

Unigene Representative Sequence: X06290

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000316300 ENST00000484276 ENST00000447678(uc003qtl.3)

miRNA Products:		OriGene 3'-UTR Clone: LPA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LPA
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LPA
		SwitchGear 3'UTR luciferase reporter plasmid: LPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LPA OriGene shRNA RFP: LPA OriGene siRNA: LPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LPA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LPA OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LPA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): LPA (NM_001401)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LPA
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LPA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LPA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat LPA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LPA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LPA

Additional cDNA sequence:

AY039748.1 X06290.1

5 DOTS entries:

DT.95162934 DT.91880191 DT.92414811 DT.453211 DT.95162941

4 AceView cDNA sequences:

CD620865 AY039748 NM_005577 X06290

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

LPA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Embryoid bodies (Two-step protocol fo...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LPA

SOURCE GeneReport for Unigene cluster: Hs.520120

SABiosciences Expression via Pathway-Focused PCR Array including LPA:

Atherosclerosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LPA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat LPA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LPA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LPA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LPA gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NWX6_CHICK⁶	Uncharacterized protein	48(a)	1 → many	3(47263284-47284746)
lizard (Anolis carolinensis)	Reptilia	--	--	49(a)	1 → many	1(211782122-211817166)
zebrafish (Danio rerio)	Actinopterygii	plg⁶	plasminogen	47(a)	1 → many	20(42720219-42734615)
honey bee (Apis mellifera)	Insecta	--	--	9(a)	possible ortholog	GroupUn.841(30640-42833)

ENSEMBL Gene Tree for LPA (if available)
TreeFam Gene Tree for LPA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LPA gene

KREMEN1² KREMEN2² PLAT² PLG² HGFAC² PLAU² HABP2² MST1²

F12² MST1L² HGF²

18/54 SIMAP similar genes for LPA using alignment to 2 protein entries: APOA_HUMAN (see all proteins) (see all similar genes):

APOA LPAL2 PLG MGC52282 DKFZp586F0824 ELANE

PROC1 CELA3B PROC PRSS38 AZU1 CELA2A

CELA3A CTRB1 ELA3A PRSS27 PRTN3 TRY6

LPA for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for LPA
PGOHUM00000250193 PGOHUM00000250194 PGOHUM00000250195 PGOHUM00000243843

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: APOA_HUMAN, P08519

Polymorphism: The reference genome sequence encodes a variant that contains 16 Kringle domains and that lack residues

533 to 3040. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele

represented here contains 38 copies of the kringle-type repeats

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142828189^1,2		--	160952125(+)	`TAAAAA/TAGGAT`	1	--	ds500¹		0	--	--	--	--
rs192843668^1,2		--	160952137(+)	`AGTTCA/GTGTCC`	1	--	ds500¹		0	--	--	--	--
rs41266385^1,2	C,F,	--	160952333(-)	`ATTTCT/GTTTAG`	1	--	ds500¹		3		NS NA	212
rs41266383^1,2	C,	--	160952490(-)	`TTCAAA/CATTTT`	1	--	ds500¹		4		NS WA	210
rs184861410^1,2		--	160952499(+)	`AAGACC/TAAAAC`	1	--	ds500¹		0	--	--	--	--
rs190149733^1,2		--	160952508(+)	`ACCAAA/GATTAA`	1	--	ds500¹		0	--	--	--	--
rs41266381^1,2	C,	--	160952621(-)	`ATTTTT/GGGTAT`	1	--	ut3¹		2		NS	92
rs73012273^1,2		--	160952667(+)	`GTCTTC/GGTTTG`	1	--	ut3¹		0	--	--	--	--
rs112038494^1,2	F	--	160952754(+)	`TCTCCC/TGTCCA`	1	--	ut3¹		1		CSA	4
rs186413938^1,2	C,	--	160952780(+)	`TCATTC/TCCTCA`	2	E G	mis¹		1		EU	1323

HapMap Linkage Disequilibrium report for LPA (160952515 - 161087407 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for LPA
15/17 CNVs (see all 17): 36470 4514 8530 99781 36472 0604 69640 94142 6521 9552 31306 36469 7542 3648 81677
1 Indel: 43715
Human Gene Mutation Database (HGMD): LPA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LPA

DNA2.0 Custom Variant and Variant Library Synthesis for LPA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LPA for disorders           About GeneDecksing

OMIM gene information: 152200    OMIM disorders: --

20/104 diseases for LPA (see all 104):    About MalaCards

lpa deficiency, congenital hyperlipoproteinemia type iii atherosclerosis lipoprotein lipase deficiency

retinol binding protein hyperlipoproteinemia aortic valve stenosis myocardial infarction

growth hormone deficiency abdominal aortic aneurysm peripheral vascular disease acute myocardial infarction

nonalcoholic steatohepatitis type 2 diabetes mellitus aortic aneurysm coronary stenosis

hdl deficiency coronary heart disease diabetes mellitus alagille syndrome

11 diseases from the University of Copenhagen DISEASES database for LPA:

Atherosclerosis Tangier disease Coronary heart disease Diabetes mellitus

Myocardial infarction Familial hyperlipidemia Norum disease Hypertension

Cerebrovascular accident Kidney failure Nephrotic syndrome

10/71 Novoseek disease relationships for LPA gene (see all 71) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerosis	72.6	59	15631881 (3), 19230958 (2), 12679978 (2), 10984073 (2) (see all 43)
dyslipoproteinemia	71.1	2	10155712 (1), 8503411 (1)
hyperlipoproteinemia type iii	69.7	3	15369733 (1), 12929622 (1), 1730728 (1)
coronary heart disease	65.6	21	10817252 (2), 8989507 (1), 12891257 (1), 16297766 (1) (see all 15)
hypertriglyceridemia	64.4	5	11740190 (1), 1531990 (1), 9179544 (1)
endogenous hypertriglyceridemia	62.4	3	12575193 (1), 17680536 (1), 12600077 (1)
hypercholesterolemia	57.6	6	7826229 (1), 7981178 (1), 12842838 (1), 9179544 (1) (see all 5)
hyperlipidemia	57.5	1	1731853 (1)
cardiovascular diseases	56.7	15	7857388 (1), 9693262 (1), 10751199 (1), 1345006 (1) (see all 15)
coronary artery disease	53.5	16	1531990 (2), 9915664 (1), 1684707 (1), 1527895 (1) (see all 14)

Genatlas disease: LPA

coronary atherosclerosis,premature,with high Lpa

Genetic Association Database (GAD): LPA
Human Genome Epidemiology (HuGE) Navigator: LPA (128 documents)

Export disorders for LPA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LPA gene, integrated from 9 sources (see all 647):
(articles sorted by number of sources associating them with LPA)

Utopia: connect your pdf to the dynamic
world of online information

cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. (PubMed id 3670400)^{1, 2, 3} McLean J.W.... Lawn R.M. (1987)
Lp(a) and apoE polymorphisms in young South African Indians with myocardial infarction. (PubMed id 15258620)^{1, 4, 9} Ranjith N....Naidoo D.P. (2004)
Apolipoprotein(a) gene polymorphisms (TTTTA)n and G/A-914 affect Lp(a) levels in ischemic heart disease patients from Serbia. (PubMed id 16053196)^{1, 4} Dincic D....Alavantic D. (2005)
Association of polymorphisms of the apolipoprotein(a) gene with lipoprotein(a) levels and myocardial infarction. (PubMed id 12578871)^{1, 4} Holmer S.R....Schunkert H. (2003)
APO(a) variants and lipoprotein(a) in men with or without myocardial infarction. (PubMed id 12127051)^{1, 4} Chimienti G....Pepe G. (2002)
Apolipoprotein molecular variation in Moroccan Berbers: pentanucleotide (TTTTA)n repeat in the LPA gene and APOE-C1-C2 gene cluster. (PubMed id 12220441)^{1, 4} Harich N....Moral P. (2002)
Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers. (PubMed id 12359323)^{1, 4} Compton D....Hardy J. (2002)
Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease. (PubMed id 12082592)^{1, 4} Zee R.Y....Lindpainter K. (2002)
Genetic effect of two APOA repeat polymorphisms (kringle 4 and pentanucleotide repeats) on plasma Lp(a) levels in American Samoans. (PubMed id 11332648)^{1, 4} DePrince K....Kamboh M.I. (2001)
Genetic evaluation of lipoprotein(a) in intracranial aneurysm disease. (PubMed id 11440434)^{1, 4} Roberts G.A....Collins P.B. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4018	HGNC: 6667	AceView: LPA	Ensembl:ENSG00000198670	euGenes: HUgn4018
ECgene: LPA	H-InvDB: LPA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LPA	Pharmacogenomics, SNPs, Pathways
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA

Intellectual Property for LPA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LPA gene:
Search GeneIP for patents involving LPA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LPA
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for LPA		OriGene shRNA RFP for LPA
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LPA		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LPA
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for LPA		OriGene 3'-UTR Clone for LPA
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LPA		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LPA
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for LPA		OriGene Custom Protein Services for LPA
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LPA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LPA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LPA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LPA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LPA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LPA

	GenScript Custom Purified and Recombinant Proteins Services for LPA		GenScript cDNA clones with any tag delivered in your preferred vector for LPA
	GenScript Custom Assay Services for LPA		GenScript Superior Antibodies for LPA
	GenScript Custom overexpressing Cell Line Services for LPA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in LPA promoter
	Search Chromatin IP Primers for LPA
	RT² qPCR Primer Assay in human, mouse / rat LPA
	GNC Network for LPA
	SABiosciences PCR Arrays including human, mouse, rat LPA

Search Tocris compounds for LPA

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	LPA antibodies
	LPA proteins

	Antibodies for LPA
	See all of Abcam's Antibodies, Kits and Proteins for LPA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for LPA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LPA

	SwitchGear 3'UTR luciferase reporter plasmids for LPA
	SwitchGear Promoter luciferase reporter plasmids for LPA

ThermoFisher Antibodies for LPA

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LPA

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LPA gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

LPA Gene

lipoprotein, Lp(a)

Aliases
for LPA gene

Summaries
for LPA gene

Genomic Views
for LPA gene

Proteins
for LPA gene

Protein Domains /
Families
for LPA gene

Function
for LPA gene

Pathways & Interactions
for LPA gene

Drugs & Compounds
for LPA gene

Transcripts
for LPA gene

Expression
for LPA gene

Orthologs
for LPA gene

Paralogs
for LPA gene

Genomic Variants
for LPA gene

Disorders / Diseases
for LPA gene

Publications
for LPA gene

External Searches for LPA gene

Genome Databases showing LPA gene

Other Databases showing LPA gene

Specialized Databases showing LPA gene

Intellectual Property
for LPA gene

Products
for LPA gene

View Random Gene

Microalbuminuria
Dementia
AMYLOIDOSIS SECONDARY
Peripheral Vascular Diseases
essential hypertension
Acute myocardial infarction
Hyperlipidemia
Myocardial Ischemia
Liver diseases
Atherosclerosis
ENDOGENOUS HYPERTRIGLYCERIDEMIA
Hypercholesterolemia
Nephrotic Syndrome
Coronary Stenosis
Amyloidosis
Diabetes Mellitus Insulin-Dependent
Coronary Atherosclerosis
Lipid Disorders
Dyslipidemia
RENAL DISEASE
Cerebral Infarction
Inflammation
Diabetic Nephropathies
Proteinuria
Hyperhomocysteinemia
Hyperglycemia
Hyperlipoproteinemia Type III
Renal Failure
Rheumatoid Arthritis
Tumors
Cardiovascular Diseases
Thrombosis
Necrosis
SMOKING HABIT
Coronary Heart Disease
Cirrhosis
BREAST CARCINOMA
HYPERTENSION ARTERIAL
Glioma
atherosclerotic plaque
Liver Fibrosis
INFARCT
retinopathy
Hypothyroidism
Acromegaly
Alzheimers Disease
Diabetes Mellitus
Hyperlipoproteinemia
VENOUS OCCLUSION
Calcification
Myocardial Infarction
Uremia
dyslipoproteinemia
Alagille Syndrome
Coronary Artery Disease
Alcohol withdrawal
Heart Diseases
Insulin Resistance
Bleeding
Dementia Vascular
Hypertriglyceridemia
OBESITY
restenosis
STROKE
Vascular Diseases
DYSFUNCTION THYROID
chronic liver disease
Glomerulonephritis
NIDDM
Hypercholesterolemia Familial
Renal Failure Chronic

Advanced Search

Export list of displayed genes

LPA Gene

lipoprotein, Lp(a)

Aliasesfor LPA gene

Summariesfor LPA gene

Genomic Viewsfor LPA gene

Proteinsfor LPA gene

Protein Domains /Familiesfor LPA gene

Functionfor LPA gene

Pathways & Interactionsfor LPA gene

Drugs & Compoundsfor LPA gene

Transcriptsfor LPA gene

Expression for LPA gene

Orthologsfor LPA gene

Paralogsfor LPA gene

Genomic Variantsfor LPA gene

Disorders / Diseasesfor LPA gene

Publicationsfor LPA gene

External Searches for LPA gene

Genome Databases showing LPA gene

Other Databases showing LPA gene

Specialized Databases showing LPA gene

Intellectual Propertyfor LPA gene

Productsfor LPA gene

View Random Gene

Aliases
for LPA gene

Summaries
for LPA gene

Genomic Views
for LPA gene

Proteins
for LPA gene

Protein Domains /
Families
for LPA gene

Function
for LPA gene

Pathways & Interactions
for LPA gene

Drugs & Compounds
for LPA gene

Transcripts
for LPA gene

Expression
for LPA gene

Orthologs
for LPA gene

Paralogs
for LPA gene

Genomic Variants
for LPA gene

Disorders / Diseases
for LPA gene

Publications
for LPA gene

Intellectual Property
for LPA gene

Products
for LPA gene