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Aliases for LPA Gene

Aliases for LPA Gene

  • Lipoprotein(A) 2 3
  • Lipoprotein, Lp(A) 2 3 5
  • Apo(A) 3 4
  • Lp(A) 3 4
  • Antiangiogenic AK38 Protein 3
  • Apolipoprotein(A) 2
  • EC 3.4.21.7 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • AK38 3
  • APOA 3
  • LP 3

External Ids for LPA Gene

Previous HGNC Symbols for LPA Gene

  • LP

Previous GeneCards Identifiers for LPA Gene

  • GC06U990074
  • GC06M160826
  • GC06M160707
  • GC06M160861
  • GC06M160844
  • GC06M160872
  • GC06M160952
  • GC06M158427

Summaries for LPA Gene

Entrez Gene Summary for LPA Gene

  • The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

GeneCards Summary for LPA Gene

LPA (Lipoprotein(A)) is a Protein Coding gene. Diseases associated with LPA include Pontocerebellar Hypoplasia Type 2D and Atherosclerosis. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include serine-type endopeptidase activity and endopeptidase inhibitor activity. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot for LPA Gene

  • Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.

Gene Wiki entry for LPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LPA Gene

Genomics for LPA Gene

Regulatory Elements for LPA Gene

Enhancers for LPA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LPA on UCSC Golden Path with GeneCards custom track

Genomic Location for LPA Gene

Chromosome:
6
Start:
160,531,483 bp from pter
End:
160,666,375 bp from pter
Size:
134,893 bases
Orientation:
Minus strand

Genomic View for LPA Gene

Genes around LPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LPA Gene

Proteins for LPA Gene

  • Protein details for LPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08519-APOA_HUMAN
    Recommended name:
    Apolipoprotein(a)
    Protein Accession:
    P08519
    Secondary Accessions:
    • Q5VTD7
    • Q9UD88

    Protein attributes for LPA Gene

    Size:
    4548 amino acids
    Molecular mass:
    501319 Da
    Quaternary structure:
    • Disulfide-linked to apo-B100. Binds to fibronectin and decorin.
    Miscellaneous:
    • Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.

    Three dimensional structures from OCA and Proteopedia for LPA Gene

neXtProt entry for LPA Gene

Proteomics data for LPA Gene at MOPED

Post-translational modifications for LPA Gene

  • N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.
  • Glycosylation at Asn 61, Asn 101, Asn 215, Asn 329, Asn 443, Asn 557, Asn 671, Asn 785, Asn 899, Asn 1013, Asn 1127, Asn 1241, Asn 1355, Asn 1469, Asn 1583, Asn 1697, Asn 1811, Asn 1925, Asn 2039, Asn 2153, Asn 2267, Asn 2381, Asn 2495, Asn 2609, Asn 2723, Asn 2837, Asn 2951, Asn 3065, Asn 3179, Asn 3293, Asn 3407, Asn 3521, Asn 3635, Asn 3749, Asn 3855, Asn 3889, Asn 3969, Asn 4083, and Asn 4197
  • Modification sites at PhosphoSitePlus

Other Protein References for LPA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for LPA Gene

Graphical View of Domain Structure for InterPro Entry

P08519

UniProtKB/Swiss-Prot:

APOA_HUMAN :
  • Contains 38 kringle domains.
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
Domain:
  • Contains 38 kringle domains.
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
genes like me logo Genes that share domains with LPA: view

No data available for Gene Families for LPA Gene

Function for LPA Gene

Molecular function for LPA Gene

GENATLAS Biochemistry:
lipoprotein,Lp(a),tightly linked (50k6) and highly homologous to PLG,susceptibility gene for IDDM8
UniProtKB/Swiss-Prot Function:
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.

Enzyme Numbers (IUBMB) for LPA Gene

Gene Ontology (GO) - Molecular Function for LPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 8047165
genes like me logo Genes that share ontologies with LPA: view
genes like me logo Genes that share phenotypes with LPA: view

Human Phenotype Ontology for LPA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LPA Gene

Localization for LPA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LPA Gene COMPARTMENTS Subcellular localization image for LPA gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LPA Gene

Pathways & Interactions for LPA Gene

genes like me logo Genes that share pathways with LPA: view

Gene Ontology (GO) - Biological Process for LPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006869 lipid transport IEA --
GO:0008015 blood circulation TAS 8047165
GO:0042157 lipoprotein metabolic process TAS --
genes like me logo Genes that share ontologies with LPA: view

No data available for SIGNOR curated interactions for LPA Gene

Drugs & Compounds for LPA Gene

(54) Drugs for LPA Gene - From: DrugBank, PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist 854,854
Aminocaproic Acid Approved, Investigational Pharma Target, other 26
Folic Acid Approved Nutra 4079
Nicotinamide Experimental Nutra 850,854
Folate Nutra 4079

(29) Additional Compounds for LPA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LPA: view

Transcripts for LPA Gene

mRNA/cDNA for LPA Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LPA Gene

Lipoprotein, Lp(a):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LPA Gene

No ASD Table

Relevant External Links for LPA Gene

GeneLoc Exon Structure for
LPA
ECgene alternative splicing isoforms for
LPA

Expression for LPA Gene

mRNA expression in normal human tissues for LPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LPA Gene

This gene is overexpressed in Liver (x47.1).

Protein differential expression in normal tissues from HIPED for LPA Gene

This gene is overexpressed in Synovial fluid (24.4) and Serum (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LPA Gene



SOURCE GeneReport for Unigene cluster for LPA Gene Hs.520120

genes like me logo Genes that share expression patterns with LPA: view

Protein tissue co-expression partners for LPA Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LPA Gene

Orthologs for LPA Gene

This gene was present in the common ancestor of animals.

Orthologs for LPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPA 35
  • 97.27 (n)
  • 95.1 (a)
LPA 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 42 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii plg 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13744 37
  • 33 (a)
Tequila 36
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea svh-1 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4525 36
  • 18 (a)
ManyToMany
Species with no ortholog for LPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for LPA Gene

ENSEMBL:
Gene Tree for LPA (if available)
TreeFam:
Gene Tree for LPA (if available)

Paralogs for LPA Gene

Paralogs for LPA Gene

Pseudogenes.org Pseudogenes for LPA Gene

genes like me logo Genes that share paralogs with LPA: view

Variants for LPA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for LPA Gene

APOA_HUMAN-P08519
The reference genome sequence encodes a variant that contains 16 Kringle domains and that lack residues 533 to 3040. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 38 copies of the kringle-type repeats.

Sequence variations from dbSNP and Humsavar for LPA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_006633 -
rs41259144 - 160,601,075(+) GATTT(A/C/T)GGCAG reference, missense
rs7765803 - 160,586,506(+) GAGGA(C/G)AGTTG reference, missense
rs7765781 - 160,586,464(+) AGGAA(C/G)CTCTG reference, missense
rs41272110 - 160,585,140(-) GAGGC(A/C)CACTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LPA Gene

Variant ID Type Subtype PubMed ID
dgv2024e1 CNV Complex 17122850
esv35098 CNV Gain 17911159
nsv818463 CNV Gain 17921354
dgv7013n71 CNV Gain 21882294
essv6642 CNV CNV 17122850
esv6519 CNV Loss 19470904
esv5050 CNV Duplication 18987735
esv2733055 CNV Deletion 23290073
nsv525990 CNV Loss 19592680
dgv2025e1 CNV Complex 17122850
nsv428155 CNV Gain 18775914
nsv886814 CNV Gain 21882294
nsv830852 CNV Loss 17160897
nsv5567 CNV Loss 18451855
esv2663797 CNV Deletion 23128226
esv2750777 CNV Loss 17666407
nsv290 CNV Insertion 15895083
nsv5568 CNV Insertion 18451855
nsv823905 CNV Gain 20364138
nsv509160 CNV Insertion 20534489
nsv515029 CNV Complex 21397061
nsv471501 CNV Duplication 19718026
esv28656 CNV Gain+Loss 19812545
nsv7986 CNV Gain 18304495
dgv127n17 CNV Loss 16327808
esv33502 CNV Loss 17666407
esv2530911 CNV Deletion 19546169
nsv5569 CNV Insertion 18451855
nsv348956 CNV Loss 16902084
nsv5570 CNV Insertion 18451855
esv2733056 CNV Deletion 23290073

Variation tolerance for LPA Gene

Residual Variation Intolerance Score: 99.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.42; 94.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LPA Gene

Human Gene Mutation Database (HGMD)
LPA

Disorders for LPA Gene

MalaCards: The human disease database

(34) MalaCards diseases for LPA Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pontocerebellar hypoplasia type 2d
  • progressive cerebello-cerebral atrophy
atherosclerosis
  • arteriosclerosis
lipoprotein lipase deficiency
  • lipoprotein lipase
familial hyperlipidemia
  • familial hyperlipoproteinemia
aortic atherosclerosis
  • atherosclerosis of aorta
- elite association - COSMIC cancer census association via MalaCards
Search LPA in MalaCards View complete list of genes associated with diseases

Genatlas disease for LPA Gene

coronary atherosclerosis,premature,with high Lpa

Relevant External Links for LPA

Genetic Association Database (GAD)
LPA
Human Genome Epidemiology (HuGE) Navigator
LPA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LPA
genes like me logo Genes that share disorders with LPA: view

No data available for UniProtKB/Swiss-Prot for LPA Gene

Publications for LPA Gene

  1. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. (PMID: 3670400) McLean J.W. … Lawn R.M. (Nature 1987) 2 3 4 67
  2. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. (PMID: 19880117) Arai K. … Tsimikas S. (Atherosclerosis 2010) 3 23
  3. Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation. (PMID: 19636317) BrandstAotter A. … Kronenberg F. (Int J Obes (Lond) 2009) 3 23
  4. Lp(a) and apoE polymorphisms in young South African Indians with myocardial infarction. (PMID: 15258620) Ranjith N. … Naidoo D.P. (Cardiovasc J S Afr 2004) 3 23
  5. Type of diabetes and waist-hip ratio are important determinants of serum lipoprotein (a) levels in diabetic patients. (PMID: 11947970) Nawawi H.M. … Khalid B.A. (Diabetes Res. Clin. Pract. 2002) 3 23

Products for LPA Gene

Sources for LPA Gene

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