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LPA Gene

protein-coding   GIFtS: 61
GCID: GC06M160952

Lipoprotein, Lp(A)


(Previous symbol: LP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lipoprotein, Lp(A)1 2     lp(a)2
LP1 2     Apo(a)3
AK382     EC 3.4.21.-3
APOA2     Lp(a)3
Antiangiogenic AK38 Protein2     EC 3.4.218
apo(a)2     EC 3.4.21.78
apolipoprotein(a)2     

External Ids:    HGNC: 66671   Entrez Gene: 40182   Ensembl: ENSG000001986707   OMIM: 1522005   UniProtKB: P085193   

Export aliases for LPA gene to outside databases

Previous GC identifers: GC06U990074 GC06M160826 GC06M160707 GC06M160861 GC06M160844 GC06M160872 GC06M158427


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LPA Gene:
The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen
activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically
cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated
plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein
contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type
repeats and corresponds to that found in the reference genome sequence. (provided by RefSeq, Dec 2009)

GeneCards Summary for LPA Gene:
LPA (lipoprotein, Lp(a)) is a protein-coding gene. Diseases associated with LPA include peripheral vascular disease, and norum disease. GO annotations related to this gene include endopeptidase inhibitor activity and serine-type endopeptidase activity. An important paralog of this gene is PLG.

UniProtKB/Swiss-Prot: APOA_HUMAN, P08519
Function: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able
of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330

Gene Wiki entry for LPA (Lipoprotein(a)) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the LPA gene promoter:
         CREB   PPAR-gamma1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LPA promoter sequence
   Search Chromatin IP Primers for LPA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q26   Ensembl cytogenetic band:  6q26   HGNC cytogenetic band: 6q25-q26

LPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LPA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M160952:  view genomic region     (about GC identifiers)

Start:
160,952,515 bp from pter      End:
161,087,407 bp from pter
Size:
134,893 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: APOA_HUMAN, P08519 (See protein sequence)
Recommended Name: Apolipoprotein(a) precursor  
Size: 4548 amino acids; 501319 Da
Subunit: Disulfide-linked to apo-B100. Binds to fibronectin and decorin
Miscellaneous: Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called
mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis.
O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is
thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for
fibrin(ogen) binding
6 PDB 3D structures from and Proteopedia for LPA:
1I71 (3D)        1JFN (3D)        1KIV (3D)        2FEB (3D)        3KIV (3D)        4KIV (3D)    
Secondary accessions: Q5VTD7 Q9UD88

Explore the universe of human proteins at neXtProt for LPA: NX_P08519

Explore proteomics data for LPA at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated
    state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure,
    NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected1
  • Glycosylation2 at Asn61, Asn101, Asn215, Asn329, Asn443, Asn557, Asn671, Asn785, Asn899, Asn1013,
                                 Asn1127, Asn1241, Asn1355, Asn1469, Asn1583, Asn1697, Asn1811, Asn1925, Asn2039, Asn2153 (see all 39)
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LPA (P08519) (see all 36)
     KLFDYCD  CYITGWG  PHWHQRT  CRNPDGD 


    See LPA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005568.2  
    ENSEMBL proteins: 
     ENSP00000321334   ENSP00000395608  
    Reactome Protein details: P08519

    LPA Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000001 Kringle
     IPR001314 Peptidase_S1A
     IPR013806 Kringle-like
     IPR018056 Kringle_CS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P08519

    ProtoNet protein and cluster: P08519

    3 Blocks protein domains:
    IPB000001 Kringle
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: APOA_HUMAN, P08519
    Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily
    Similarity: Contains 38 kringle domains
    Similarity: Contains 1 peptidase S1 domain


    LPA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOA_HUMAN, P08519
    Function: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able
    of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330

         Genatlas biochemistry entry for LPA:
    lipoprotein,Lp(a),tightly linked (50k6) and highly homologous to PLG,susceptibility gene for IDDM8

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.72 EC 3.4.21.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IPI2531657
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA2531657
    GO:0004866endopeptidase inhibitor activity TAS8047165
    GO:0008201heparin binding NAS2531657
         
    LPA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for LPA:
     Increased Salmonella enterica   Increased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LPA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LPA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LPA

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    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    nucleus2
    peroxisome2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    endosome1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0034358plasma lipoprotein particle IDA2531657

    LPA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LPA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lipoprotein metabolism
    Lipoprotein metabolism0.59
    LDL-mediated lipid transport0.00
    Lipid digestion, mobilization, and transport0.59
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Selected targets of HNF1
    Selected targets of HNF1
    4amb2 Integrin signaling
    amb2 Integrin signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for LPA
        amb2 Integrin signaling

    1 Reactome Pathway for LPA
        LDL-mediated lipid transport



    LPA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including LPA: 
              Atherosclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for LPA (P085193 ENSP000003213344) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGBP026753, ENSP000003060994I2D: score=2 STRING: ENSP00000306099
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    FBLN5Q9UBX53, ENSP000003450084I2D: score=1 STRING: ENSP00000345008
    CANXP278243, ENSP000002474614I2D: score=2 STRING: ENSP00000247461
    APOHP027493, ENSP000002059484I2D: score=2 STRING: ENSP00000205948
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006629lipid metabolic process NAS8047165
    GO:0006869lipid transport IEA--
    GO:0006898receptor-mediated endocytosis TAS--
    GO:0008015blood circulation TAS8047165

    LPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LPA (APOA)

    1 DrugBank Compound for LPA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aminocaproic Acid6-aminohexanoic acid (see all 7)60-32-2targetother17139284 17016423 15287725

    Selected Novoseek inferred chemical compound relationships for LPA gene (see all 68)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 83.8 281 1531990 (3), 16092061 (3), 16375584 (3), 8461626 (2) (see all 99)
    lipid 75.3 123 9029226 (4), 9542772 (2), 12380908 (2), 11165958 (2) (see all 99)
    fibrinogen 59 41 17669712 (3), 16125536 (3), 10102473 (2), 9169895 (2) (see all 28)
    cholesterol ester 54.1 3 12679198 (1), 18187430 (1), 17211855 (1)
    homocysteine 48.1 25 14977830 (3), 16125536 (3), 16103723 (1), 12297895 (1) (see all 16)
    fenofibrate 48 3 12017210 (1), 1588829 (1)
    mspi 47.4 2 1968792 (1)
    epsilon aminocaproic acid 46.1 8 8845377 (2), 1838924 (2), 9837867 (1)
    lovastatin 45.3 5 8026027 (1), 7654731 (1), 7981178 (1), 10532693 (1)
    gemfibrozil 31.6 1 9006811 (1)



    LPA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LPA gene: 
    NM_005577.2  

    Unigene Cluster for LPA:

    Lipoprotein, Lp(a)
    Hs.520120  [show with all ESTs]
    Unigene Representative Sequence: X06290
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316300 ENST00000447678(uc003qtl.3)

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      QuantiFast Probe-based Assays in human, mouse, rat LPA

    Additional mRNA sequence: 

    AY039748.1 X06290.1 

    5 DOTS entries:

    DT.95162934  DT.91880191  DT.92414811  DT.453211  DT.95162941 

    4 AceView cDNA sequences:

    CD620865 AY039748 X06290 NM_005577 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LPA expression in normal human tissues (normalized intensities)      LPA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LPA Expression
    About this image


    LPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
     
     Kidney (Urinary System)
    LPA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LPA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520120
        Pathway & Disease-focused RT2 Profiler PCR Array including LPA: 
              Atherosclerosis in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LPA gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    Uncharacterized protein
    54(a)
    1 → many
    2(442980962-443045164)
    chicken
    (Gallus gallus)
    Aves --
    --
    Uncharacterized protein
    50(a)
    42(a)
    many ↔ many
    many ↔ many
    3(44679918-44701209)
    3(44653482-44676962)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    51(a)
    1 → many
    1(211778053-211817166)
    zebrafish
    (Danio rerio)
    Actinopterygii plg6
    plasminogen
    47(a)
    1 → many
    20(42720219-42734615) ENSDARG00000023111
    fruit fly
    (Drosophila melanogaster)
    Insecta CG137443 serine-type endopeptidase 33(a)   45A1   --
    worm
    (Caenorhabditis elegans)
    Secernentea svh-16
    Protein SVH-1 (svh-1) mRNA, complete cds
    15(a)
    1 → many
    IV(8206614-8213723) WBGene00006620


    ENSEMBL Gene Tree for LPA (if available)
    TreeFam Gene Tree for LPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LPA gene
    PLG2  PLAT2  HGFAC2  HABP22  PLAU2  MST12  F122  HGF2  
    Selected SIMAP similar genes for LPA using alignment to 2 protein entries:     APOA_HUMAN (see all proteins) (see all similar genes):
    APOA    LPAL2    PLG    MGC52282    DKFZp586F0824    ELANE
    PROC1    CELA3B    PROC    PRSS38    AZU1    CELA2A
    CELA3A    CTRB1    ELA3A    PRSS27    PRTN3    CTRB2

    LPA for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for LPA
    PGOHUM00000250193 PGOHUM00000250194 PGOHUM00000250195 PGOHUM00000243843


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    APOA_HUMAN, P08519: The reference genome sequence encodes a variant that contains 16 Kringle domains and that lack
    residues 533 to 3040. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type
    domains. The allele represented here contains 38 copies of the kringle-type repeats


    Selected SNPs for LPA (see all 3061)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428281891,2
    C--160952125(+) TAAAAA/TAGGAT 1 -- ds50010--------
    rs1928436681,2
    --160952137(+) AGTTCA/GTGTCC 1 -- ds50010--------
    rs412663851,2
    C,F--160952333(-) ATTTCT/GTTTAG 1 -- ds50013Minor allele frequency- G:0.03NS NA 212
    rs412663831,2
    C,F--160952490(-) TTCAAA/CATTTT 1 -- ds50014Minor allele frequency- C:0.08NS WA 210
    rs1848614101,2
    --160952499(+) AAGACC/TAAAAC 1 -- ds50010--------
    rs1901497331,2
    --160952508(+) ACCAAA/GATTAA 1 -- ds50010--------
    rs412663811,2
    C,F--160952621(-) ATTTTT/GGGTAT 1 -- ut312Minor allele frequency- G:0.01NS 92
    rs730122731,2
    --160952667(+) GTCTTC/GGTTTG 1 -- ut310--------
    rs1120384941,2
    F--160952754(+) TCTCCC/TGTCCA 1 -- ut311Minor allele frequency- T:0.50CSA 4
    rs1864139381,2
    C--160952780(+) TCATTC/TCCTCA 2 E G mis11Minor allele frequency- T:0.00EU 1323

    HapMap Linkage Disequilibrium report for LPA (160952515 - 161087407 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LPA (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2530911CNV Deletion19546169
    esv2733055CNV Deletion23290073
    esv2663797CNV Deletion23128226
    esv2733056CNV Deletion23290073
    esv5050CNV Duplication18987735
    nsv471501CNV Duplication19718026
    nsv5569CNV Insertion18451855
    nsv5568CNV Insertion18451855
    nsv509160CNV Insertion20534489
    nsv5570CNV Insertion18451855

    Human Gene Mutation Database (HGMD): LPA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LPA
    DNA2.0 Custom Variant and Variant Library Synthesis for LPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 152200    OMIM disorders: --

    Selected diseases for LPA (see all 99):    About MalaCards
    peripheral vascular disease    norum disease    hyperlipoproteinemia type iii    familial hdl deficiency
    alagille syndrome    atherosclerosis    coronary artery disease    aneurysm disease
    carotid artery disease    coronary stenosis    lipoprotein lipase deficiency    familial hyperlipidemia
    vascular disease    aortic atherosclerosis    hypobetalipoproteinemia    hypoalphalipoproteinemia
    nephrosclerosis    hypertriglyceridemia    abetalipoproteinemia    xanthomatosis

    10 diseases from the University of Copenhagen DISEASES database for LPA:
    Atherosclerosis     Tangier disease     Coronary heart disease     Diabetes mellitus
    Myocardial infarction     Familial hyperlipidemia     Norum disease     Kidney disease
    Hypertension     Cerebrovascular accident

    LPA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for LPA gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 72.6 59 15631881 (3), 19230958 (2), 12679978 (2), 10984073 (2) (see all 43)
    dyslipoproteinemia 71.1 2 10155712 (1), 8503411 (1)
    hyperlipoproteinemia type iii 69.7 3 15369733 (1), 12929622 (1), 1730728 (1)
    coronary heart disease 65.6 21 10817252 (2), 8989507 (1), 12891257 (1), 16297766 (1) (see all 15)
    hypertriglyceridemia 64.4 5 11740190 (1), 1531990 (1), 9179544 (1)
    endogenous hypertriglyceridemia 62.4 3 12575193 (1), 17680536 (1), 12600077 (1)
    hypercholesterolemia 57.6 6 7826229 (1), 7981178 (1), 12842838 (1), 9179544 (1) (see all 5)
    hyperlipidemia 57.5 1 1731853 (1)
    cardiovascular diseases 56.7 15 7857388 (1), 9693262 (1), 10751199 (1), 1345006 (1) (see all 15)
    coronary artery disease 53.5 16 1531990 (2), 9915664 (1), 1684707 (1), 1527895 (1) (see all 14)

    Genatlas disease: LPA
    coronary atherosclerosis,premature,with high Lpa

    Genetic Association Database (GAD): LPA
    Human Genome Epidemiology (HuGE) Navigator: LPA (128 documents)

    Export disorders for LPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LPA gene, integrated from 10 sources (see all 674):
    (articles sorted by number of sources associating them with LPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. (PubMed id 3670400)1, 2, 3 McLean J.W.... Lawn R.M. (Nature 1987)
    2. Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation. (PubMed id 19636317)1, 4, 9 BrandstAotter A....Kronenberg F. (Int J Obes (Lond) 2009)
    3. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. (PubMed id 19880117)1, 4, 9 Arai K....Tsimikas S. (Atherosclerosis 2010)
    4. Lp(a) and apoE polymorphisms in young South African Indians with myocardial infarction. (PubMed id 15258620)1, 4, 9 Ranjith N....Naidoo D.P. (Cardiovasc J S Afr 2004)
    5. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PubMed id 22331829)1, 4 Chasman D.I....Ridker P.M. (Circ Cardiovasc Genet 2012)
    6. Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). (PubMed id 22368281)1, 4 Deshmukh H.A....Hitman G.A. (J. Lipid Res. 2012)
    7. Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes. (PubMed id 21900290)1, 4 Qi Q....Qi L. (Eur. Heart J. 2012)
    8. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (Nat. Genet. 2011)
    9. Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk. (PubMed id 21127300)1, 4 Ronald J....Jarvik G.P. ( a journal of cerebral circulation 2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4018 HGNC: 6667 AceView: LPA Ensembl:ENSG00000198670 euGenes: HUgn4018
    ECgene: LPA H-InvDB: LPA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LPA Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LPA gene:
    Search GeneIP for patents involving LPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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