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Aliases for LOXL4 Gene

Aliases for LOXL4 Gene

  • Lysyl Oxidase Like 4 2 3 5
  • Lysyl Oxidase-Related Protein C 3 4
  • Lysyl Oxidase-Like Protein 4 3 4
  • LOXC 3 4
  • Lysyl Oxidase-Like 4 Pseudogene 3
  • Lysyl Oxidase Homolog 4 3
  • Lysyl Oxidase Related C 3
  • Lysyl Oxidase-Like 4 2
  • EC 1.4.3.- 4
  • EC 1.4.3 61

External Ids for LOXL4 Gene

Previous GeneCards Identifiers for LOXL4 Gene

  • GC10M098900
  • GC10M099241
  • GC10M100138
  • GC10M099672
  • GC10M099997
  • GC10M093632

Summaries for LOXL4 Gene

Entrez Gene Summary for LOXL4 Gene

  • This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LOXL4 Gene

LOXL4 (Lysyl Oxidase Like 4) is a Protein Coding gene. Diseases associated with LOXL4 include Squamous Cell Carcinoma, Head And Neck. Among its related pathways are Elastic fibre formation and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include copper ion binding and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. An important paralog of this gene is LOXL3.

UniProtKB/Swiss-Prot for LOXL4 Gene

  • May modulate the formation of a collagenous extracellular matrix.

Gene Wiki entry for LOXL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOXL4 Gene

Genomics for LOXL4 Gene

Regulatory Elements for LOXL4 Gene

Enhancers for LOXL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F098132 0.5 ENCODE 44.8 +133.8 133788 3.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LOXL4 R3HCC1L MARVELD1 EXOSC1 ENSG00000230928 ENSG00000278752
GH10F098141 0.5 Ensembl 29.2 +126.1 126050 1.6 HDAC1 PKNOX1 ZNF366 THAP11 ZNF362 CEBPB ZEB2 ZNF843 ZFP69B CEBPA LOXL4 ENSG00000230928 R3HCC1L GC10P098173
GH10F098137 0.7 ENCODE 28.7 +130.2 130179 0.9 TCF7 ZBTB40 LOXL4 ENSG00000230928 R3HCC1L GC10P098173
GH10F098168 0.6 Ensembl 28.6 +99.9 99850 0.4 ELF3 SOX13 CEBPG YY1 RARA HNF4G NR2F6 CREM THAP11 MIXL1 LOXL4 ENSG00000230928 GC10P098173 R3HCC1L
GH10F097291 0.6 ENCODE 26.9 +975.6 975620 3.2 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143 LOXL4 ENSG00000230928 SLIT1 ARHGAP19 MARVELD1 RPL13AP5 RPL12P27 ARHGAP19-SLIT1 ENSG00000231398
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LOXL4 on UCSC Golden Path with GeneCards custom track

Promoters for LOXL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000360120 -50 1001 SAP130 ZNF48 HBP1 FOSL1 POLR2A ADNP NFE2 GATAD2A ZNF511 FOXA3

Genomic Location for LOXL4 Gene

Chromosome:
10
Start:
98,247,686 bp from pter
End:
98,268,250 bp from pter
Size:
20,565 bases
Orientation:
Minus strand

Genomic View for LOXL4 Gene

Genes around LOXL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOXL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOXL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOXL4 Gene

Proteins for LOXL4 Gene

  • Protein details for LOXL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JB6-LOXL4_HUMAN
    Recommended name:
    Lysyl oxidase homolog 4
    Protein Accession:
    Q96JB6
    Secondary Accessions:
    • Q5W0B3
    • Q96DY1
    • Q96PC0
    • Q9H6T5

    Protein attributes for LOXL4 Gene

    Size:
    756 amino acids
    Molecular mass:
    84483 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Cofactor:
    Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH07522.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LOXL4 Gene

Selected DME Specific Peptides for LOXL4 Gene

Post-translational modifications for LOXL4 Gene

  • The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
  • Glycosylation at Asn 198 and Asn 629
  • Modification sites at PhosphoSitePlus

Other Protein References for LOXL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for LOXL4 Gene

Suggested Antigen Peptide Sequences for LOXL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JB6

UniProtKB/Swiss-Prot:

LOXL4_HUMAN :
  • Contains 4 SRCR domains.
  • Belongs to the lysyl oxidase family.
Domain:
  • Contains 4 SRCR domains.
Family:
  • Belongs to the lysyl oxidase family.
genes like me logo Genes that share domains with LOXL4: view

No data available for Gene Families for LOXL4 Gene

Function for LOXL4 Gene

Molecular function for LOXL4 Gene

UniProtKB/Swiss-Prot Function:
May modulate the formation of a collagenous extracellular matrix.

Enzyme Numbers (IUBMB) for LOXL4 Gene

Gene Ontology (GO) - Molecular Function for LOXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005507 copper ion binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity IEA --
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA --
genes like me logo Genes that share ontologies with LOXL4: view
genes like me logo Genes that share phenotypes with LOXL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LOXL4

miRNA for LOXL4 Gene

miRTarBase miRNAs that target LOXL4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LOXL4 Gene

Localization for LOXL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LOXL4 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LOXL4 Gene COMPARTMENTS Subcellular localization image for LOXL4 gene
Compartment Confidence
extracellular 5
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LOXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0043235 receptor complex IDA 23382219
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with LOXL4: view

Pathways & Interactions for LOXL4 Gene

genes like me logo Genes that share pathways with LOXL4: view

Gene Ontology (GO) - Biological Process for LOXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LOXL4: view

No data available for SIGNOR curated interactions for LOXL4 Gene

Drugs & Compounds for LOXL4 Gene

(2) Drugs for LOXL4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved Pharma 172

(1) Additional Compounds for LOXL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LOXL4: view

Transcripts for LOXL4 Gene

mRNA/cDNA for LOXL4 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LOXL4 Gene

Lysyl oxidase-like 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LOXL4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: - - - -
SP3:
SP4: - - - -
SP5: -

Relevant External Links for LOXL4 Gene

GeneLoc Exon Structure for
LOXL4
ECgene alternative splicing isoforms for
LOXL4

Expression for LOXL4 Gene

mRNA expression in normal human tissues for LOXL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LOXL4 Gene

This gene is overexpressed in Islet of Langerhans (36.2) and Bone marrow mesenchymal stem cell (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LOXL4 Gene



Protein tissue co-expression partners for LOXL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of LOXL4 Gene:

LOXL4

SOURCE GeneReport for Unigene cluster for LOXL4 Gene:

Hs.306814

mRNA Expression by UniProt/SwissProt for LOXL4 Gene:

Q96JB6-LOXL4_HUMAN
Tissue specificity: Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.
genes like me logo Genes that share expression patterns with LOXL4: view

Primer Products

No data available for mRNA differential expression in normal tissues for LOXL4 Gene

Orthologs for LOXL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LOXL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOXL4 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia LOXL4 34 35
  • 88.83 (n)
cow
(Bos Taurus)
Mammalia LOXL4 34 35
  • 88.53 (n)
rat
(Rattus norvegicus)
Mammalia Loxl4 34
  • 85.54 (n)
mouse
(Mus musculus)
Mammalia Loxl4 34 16 35
  • 85.36 (n)
oppossum
(Monodelphis domestica)
Mammalia LOXL4 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LOXL4 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOXL4 34 35
  • 71.99 (n)
lizard
(Anolis carolinensis)
Reptilia LOXL4 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia loxl4 34
  • 65.42 (n)
zebrafish
(Danio rerio)
Actinopterygii loxl4 34 35
  • 62.54 (n)
LOXL4 (2 of 2) 35
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta lox 36
  • 42 (a)
lox2 36
  • 40 (a)
Species where no ortholog for LOXL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LOXL4 Gene

ENSEMBL:
Gene Tree for LOXL4 (if available)
TreeFam:
Gene Tree for LOXL4 (if available)

Paralogs for LOXL4 Gene

Paralogs for LOXL4 Gene

(2) SIMAP similar genes for LOXL4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for LOXL4 Gene

genes like me logo Genes that share paralogs with LOXL4: view

Variants for LOXL4 Gene

Sequence variations from dbSNP and Humsavar for LOXL4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10736124 -- 98,249,752(+) GATTC(C/T)AGCAT intron-variant
rs10736125 -- 98,262,689(+) AGCCC(A/G)AGAAG intron-variant
rs10736126 -- 98,266,167(+) GACAG(A/G)TCGGC intron-variant
rs10748722 -- 98,252,254(+) GTGCC(C/T)TGGGC intron-variant
rs10748723 -- 98,266,059(+) GCAGA(A/G)TGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LOXL4 Gene

Variant ID Type Subtype PubMed ID
esv2676146 CNV deletion 23128226
esv2739962 CNV deletion 23290073
esv3261051 CNV deletion 24192839
esv3546734 CNV deletion 23714750
esv3624332 CNV loss 21293372
nsv1069959 CNV deletion 25765185
nsv1152838 CNV deletion 26484159
nsv831954 CNV loss 17160897

Variation tolerance for LOXL4 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.15; 95.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LOXL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LOXL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LOXL4 Gene

Disorders for LOXL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LOXL4 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • squamous cell carcinoma, head and neck, somatic
- elite association - COSMIC cancer census association via MalaCards
Search LOXL4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LOXL4

Genetic Association Database (GAD)
LOXL4
Human Genome Epidemiology (HuGE) Navigator
LOXL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LOXL4
genes like me logo Genes that share disorders with LOXL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LOXL4 Gene

Publications for LOXL4 Gene

  1. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (PMID: 17287949) Akagawa H. … Inoue I. (Hum. Genet. 2007) 3 22 46 64
  2. A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain. (PMID: 11691588) Asuncion L. … Csiszar K. (Matrix Biol. 2001) 3 4 22 64
  3. Molecular cloning and biological activity of a novel lysyl oxidase- related gene expressed in cartilage. (PMID: 11292829) Ito H. … Nakamura T. (J. Biol. Chem. 2001) 2 3 4 64
  4. Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. (PMID: 11691589) Maeki J.M. … Kivirikko K.I. (Matrix Biol. 2001) 3 4 22 64
  5. Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities. (PMID: 19015874) Sebban S. … Reich R. (Virchows Arch. 2009) 3 22 64

Products for LOXL4 Gene

Sources for LOXL4 Gene

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