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LOXL4 Gene

protein-coding   GIFtS: 63
GCID: GC10M099997

Lysyl Oxidase-Like 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysyl Oxidase-Like 41 2     Lysyl Oxidase Related C2
Lysyl Oxidase-Like Protein 42 3     Lysyl Oxidase-Like 4 Pseudogene2
Lysyl Oxidase-Related Protein C2 3     EC 1.4.3.-3
LOXC2 3     EC 1.4.38
Lysyl Oxidase Homolog 42     

External Ids:    HGNC: 171711   Entrez Gene: 841712   Ensembl: ENSG000001381317   OMIM: 6073185   UniProtKB: Q96JB63   

Export aliases for LOXL4 gene to outside databases

Previous GC identifers: GC10M098900 GC10M099241 GC10M100138 GC10M099672 GC10M093632


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LOXL4 Gene:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to
the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the
first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the
C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain
this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation,
senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. (provided by
RefSeq, Jul 2008)

GeneCards Summary for LOXL4 Gene:
LOXL4 (lysyl oxidase-like 4) is a protein-coding gene. Diseases associated with LOXL4 include intracranial aneurysm, and endometriosis. GO annotations related to this gene include protein-lysine 6-oxidase activity and copper ion binding. An important paralog of this gene is LOXL2.

UniProtKB/Swiss-Prot: LOXL4_HUMAN, Q96JB6
Function: May modulate the formation of a collagenous extracellular matrix

Gene Wiki entry for LOXL4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LOXL4 gene promoter:
         GR   RelA   NF-kappaB   Tal-1beta   NF-AT   Evi-1   STAT3   GR-alpha   ITF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LOXL4 promoter sequence
   Search Chromatin IP Primers for LOXL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LOXL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24

LOXL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOXL4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M099997:  view genomic region     (about GC identifiers)

Start:
100,007,443 bp from pter      End:
100,028,007 bp from pter
Size:
20,565 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LOXL4_HUMAN, Q96JB6 (See protein sequence)
Recommended Name: Lysyl oxidase homolog 4 precursor  
Size: 756 amino acids; 84483 Da
Cofactor: Copper (By similarity)
Cofactor: Contains 1 lysine tyrosylquinone (By similarity)
Sequence caution: Sequence=AAH07522.1; Type=Erroneous initiation;
Secondary accessions: Q5W0B3 Q96DY1 Q96PC0 Q9H6T5

Explore the universe of human proteins at neXtProt for LOXL4: NX_Q96JB6

Explore proteomics data for LOXL4 at MOPED

Post-translational modifications: 

  • The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine
    with a topaquinone produced by oxidation of tyrosine1
  • Glycosylation2 at Asn198, Asn629
  • Selected DME Specific Peptides for LOXL4 (Q96JB6) (see all 8)
     ESDFSNN  RRLLRFS  CHRHYHS  IHLSEVRC 


    See LOXL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115587.6  
    ENSEMBL proteins: 
     ENSP00000260702  
    Reactome Protein details: Q96JB6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001190 SRCR
     IPR001695 Lysyl_oxidase
     IPR017448 Srcr_rcpt-rel
     IPR019828 Lysyl_oxidase_CS

    Graphical View of Domain Structure for InterPro Entry Q96JB6

    ProtoNet protein and cluster: Q96JB6

    2 Blocks protein domains:
    IPB001190 Speract/scavenger receptor
    IPB001695 Lysyl oxidase


    UniProtKB/Swiss-Prot: LOXL4_HUMAN, Q96JB6
    Similarity: Belongs to the lysyl oxidase family
    Similarity: Contains 4 SRCR domains


    LOXL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LOXL4_HUMAN, Q96JB6
    Function: May modulate the formation of a collagenous extracellular matrix

         Enzyme Numbers (IUBMB): EC 1.4.3.-1 EC 1.4.32

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004720protein-lysine 6-oxidase activity IEA--
    GO:0005044scavenger receptor activity IEA--
    GO:0005507copper ion binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0016641oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor ----
         
    LOXL4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LOXL4
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    hsa-mir-124-3p (MIRT022543), hsa-mir-335-5p (MIRT017606)

    Block miRNA regulation of human, mouse, rat LOXL4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LOXL4 (see all 43):
    hsa-miR-193a-3p hsa-let-7d hsa-miR-29a hsa-let-7g hsa-miR-133a hsa-let-7a hsa-miR-330-3p hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmidLOXL4 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOXL4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOXL4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LOXL4_HUMAN, Q96JB6: Secreted, extracellular space (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0016020membrane IEA--
    GO:0043235receptor complex IDA--
    GO:0070062extracellular vesicular exosome IDA19199708

    LOXL4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LOXL4 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen formation0.75
    Crosslinking of collagen fibrils0.00
    Assembly of collagen fibrils and other multimeric structures0.62
    2Elastic fibre formation
    Elastic fibre formation0.73
    3Degradation of the extracellular matrix
    Extracellular matrix organization0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for LOXL4
        Crosslinking of collagen fibrils
    Elastic fibre formation



    LOXL4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LOXL4
    Interactions:

        Search GeneGlobe Interaction Network for LOXL4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for LOXL4 (Q96JB61, 2, 3 ENSP000002607024) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156451, 2, 3, ENSP000001663454EBI-749562,EBI-358993 MINT-67547 I2D: score=5 STRING: ENSP00000166345
    EGFL7Q9UHF13, ENSP000003078434I2D: score=1 STRING: ENSP00000307843
    COL2A1P024583, ENSP000003698894I2D: score=1 STRING: ENSP00000369889
    APOEP026493I2D: score=1 
    CDC37Q165433I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    LOXL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LOXL4

    1 HMDB Compound for LOXL4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--

    3 Novoseek inferred chemical compound relationships for LOXL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amine 61.7 7 14551188 (4), 19724858 (1), 18949373 (1)
    copper 31.6 1 12686136 (1)
    cysteine 16.4 3 14551188 (2), 11691588 (1)



    LOXL4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LOXL4 gene: 
    NM_032211.6  

    Unigene Cluster for LOXL4:

    Lysyl oxidase-like 4
    Hs.306814  [show with all ESTs]
    Unigene Representative Sequence: BC013153
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260702(uc001kpa.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate LOXL4 (see all 43):
    hsa-miR-193a-3p hsa-let-7d hsa-miR-29a hsa-let-7g hsa-miR-133a hsa-let-7a hsa-miR-330-3p hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmidLOXL4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat LOXL4
      QuantiFast Probe-based Assays in human, mouse, rat LOXL4

    Additional mRNA sequence: 

    AF338441.1 AF395336.1 AK025542.1 AK172781.1 AY036093.1 BC007522.1 BC013153.1 BC035470.1 

    7 DOTS entries:

    DT.412273  DT.100688750  DT.75179047  DT.121282903  DT.121282907  DT.95119001  DT.121282906 

    2 AceView cDNA sequences:

    BG761124 BC015656 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LOXL4    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                          -                                                                                                                     
    SP2:                          -           -     -     -                                                                                             
    SP3:                                                                                                                                                
    SP4:        -     -     -     -                                                                                                                     
    SP5:                                                                          -                                                                     


    ECgene alternative splicing isoforms for LOXL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LOXL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTTCTTGA
    LOXL4 Expression
    About this image


    LOXL4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Eye (Sensory Organs)
             Retina
    LOXL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LOXL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306814

    UniProtKB/Swiss-Prot: LOXL4_HUMAN, Q96JB6
    Tissue specificity: Expressed in many tissues, the highest levels among the tissues studied being in the skeletal
    muscle, testis and pancreas. Expressed in cartilage

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    QuantiFast Probe-based Assays in human, mouse, rat LOXL4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOXL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LOXL4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Loxl41 , 5 lysyl oxidase-like 41, 5 85.36(n)1
    86.9(a)1
      19 (36.56 cM)5
    675731  NM_001164311.11  NP_001157783.11 
     425939825 
    chicken
    (Gallus gallus)
    Aves LOXL41 lysyl oxidase-like 4 71.99(n)
    68.49(a)
      769927  XM_004942178.1  XP_004942235.1 
    lizard
    (Anolis carolinensis)
    Reptilia LOXL46
    lysyl oxidase-like 4
    66(a)
    1 ↔ 1
    3(38824577-38834920)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia loxl41 lysyl oxidase-like 4 65.42(n)
    65.79(a)
      100494701  XM_002936440.2  XP_002936486.1 
    zebrafish
    (Danio rerio)
    Actinopterygii loxl41 lysyl oxidase-like 4 62.54(n)
    60.25(a)
      100320658  XM_002664212.3  XP_002664258.3 


    ENSEMBL Gene Tree for LOXL4 (if available)
    TreeFam Gene Tree for LOXL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LOXL4 gene
    LOXL22  CD62  CD163L12  CD1632  LOXL32  SSC5D2  PRSS122  CD5L2  
    LOX2  SRCRB4D2  LOXL12  DMBT12  
    2 SIMAP similar genes for LOXL4 using alignment to 1 protein entry:     LOXL4_HUMAN:
    LOXL2    LOXL3

    LOXL4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LOXL4
    PGOHUM00000238604


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LOXL4 (see all 653)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408270261,2
    --100006972(+) GCTCCC/GTCTGC 1 -- ds50010--------
    rs1925177391,2
    --100006987(+) TGAAGC/GAGATG 1 -- ds50010--------
    rs1501505361,2
    --100007062(+) TTCCCC/TGGAAC 1 -- ds50010--------
    rs1855139961,2
    --100007063(+) TCCCCA/GGAACA 1 -- ds50010--------
    rs1154700631,2
    C,F--100007123(+) TCTTGT/CGATGT 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1384327651,2
    --100007185(+) GCTTCA/GCAGCC 1 -- ds50010--------
    rs49191891,2
    C,F,H--100007243(+) TCCTTC/TACCCC 1 -- ds500117Minor allele frequency- T:0.12NS NA WA CSA EA 1266
    rs118169981,2
    C,F,H--100007362(+) GCCCTG/CTGTAT 1 -- ds50015Minor allele frequency- C:0.22NA WA 244
    rs1893702611,2
    --100007381(+) CTGGCC/TCCATG 1 -- ds50010--------
    rs1492778351,2
    --100007433(+) AATCAC/GAGCTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for LOXL4 (100007443 - 100028007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LOXL4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739962CNV Deletion23290073
    esv2676146CNV Deletion23128226
    nsv831954CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607318    OMIM disorders: --

    8 diseases for LOXL4:    
    About MalaCards
    intracranial aneurysm    endometriosis    infertility    alzheimer's disease
    squamous cell carcinoma    adenocarcinoma    retinitis    breast cancer


    LOXL4 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for LOXL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hnscc 64.9 9 18949373 (3), 17354256 (3)
    carcinoma squamous cell 26.7 6 18949373 (2), 17354256 (2)
    carcinoma 14.2 3 12894545 (1), 17354256 (1)
    tumors 6.59 4 19015874 (1), 19724858 (1), 18949373 (1)
    cancer 0 2 19015874 (1), 18202753 (1)

    Genetic Association Database (GAD): LOXL4
    Human Genome Epidemiology (HuGE) Navigator: LOXL4 (2 documents)

    Export disorders for LOXL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LOXL4 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with LOXL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and biological activity of a novel lysyl oxidase- related gene expressed in cartilage. (PubMed id 11292829)1, 2, 3 Ito H....Nakamura T. (J. Biol. Chem. 2001)
    2. A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain. (PubMed id 11691588)1, 2, 9 Asuncion L....Csiszar K. (Matrix Biol. 2001)
    3. Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. (PubMed id 11691589)1, 2, 9 Maeki J.M.... Kivirikko K.I. (Matrix Biol. 2001)
    4. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (PubMed id 17287949)1, 4, 9 Akagawa H....Inoue I. (Hum. Genet. 2007)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer. (PubMed id 18202753)1, 9 Weise J.B....GAPrAPgh T. (Int. J. Oncol. 2008)
    9. Lysyl oxidase like 4, a novel target gene of TGF-beta1 signaling, can negatively regulate TGF-beta1-induced cell motility in PLC/PRF/5 hepatoma cells. (PubMed id 18586005)1, 9 Kim D.J....Yeom Y.I. (Biochem. Biophys. Res. Commun. 2008)
    10. Functional analysis of the 5' flanking domain of the LOXL4 gene in head and neck squamous cell carcinoma cells. (PubMed id 18949373)1, 9 GAPrAPgh T....Csiszar K. (Int. J. Oncol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84171 HGNC: 17171 AceView: LOXL4.1 Ensembl:ENSG00000138131 euGenes: HUgn84171
    ECgene: LOXL4 H-InvDB: LOXL4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LOXL4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LOXL4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LOXL4 gene:
    Search GeneIP for patents involving LOXL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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