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Aliases for LOXL4 Gene

Aliases for LOXL4 Gene

  • Lysyl Oxidase-Like 4 2 3
  • Lysyl Oxidase-Related Protein C 3 4
  • Lysyl Oxidase-Like Protein 4 3 4
  • LOXC 3 4
  • Lysyl Oxidase-Like 4 Pseudogene 3
  • Lysyl Oxidase Homolog 4 3
  • Lysyl Oxidase Related C 3
  • EC 1.4.3.- 4
  • EC 1.4.3 63

External Ids for LOXL4 Gene

Previous GeneCards Identifiers for LOXL4 Gene

  • GC10M098900
  • GC10M099241
  • GC10M100138
  • GC10M099672
  • GC10M099997
  • GC10M093632

Summaries for LOXL4 Gene

Entrez Gene Summary for LOXL4 Gene

  • This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

GeneCards Summary for LOXL4 Gene

LOXL4 (Lysyl Oxidase-Like 4) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Elastic fibre formation. GO annotations related to this gene include copper ion binding and protein-lysine 6-oxidase activity. An important paralog of this gene is LOXL1.

UniProtKB/Swiss-Prot for LOXL4 Gene

  • May modulate the formation of a collagenous extracellular matrix

Gene Wiki entry for LOXL4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOXL4 Gene

Genomics for LOXL4 Gene

Regulatory Elements for LOXL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LOXL4 Gene

98,247,686 bp from pter
98,268,250 bp from pter
20,565 bases
Minus strand

Genomic View for LOXL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LOXL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOXL4 Gene

Proteins for LOXL4 Gene

  • Protein details for LOXL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysyl oxidase homolog 4
    Protein Accession:
    Secondary Accessions:
    • Q5W0B3
    • Q96DY1
    • Q96PC0
    • Q9H6T5

    Protein attributes for LOXL4 Gene

    756 amino acids
    Molecular mass:
    84483 Da
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489; Note=Contains 1 lysine tyrosylquinone.;
    Quaternary structure:
    No Data Available
    • Sequence=AAH07522.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LOXL4 Gene

Proteomics data for LOXL4 Gene at MOPED

Selected DME Specific Peptides for LOXL4 Gene

Post-translational modifications for LOXL4 Gene

  • The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine
  • Glycosylation at Asn198 and Asn629
  • Modification sites at PhosphoSitePlus

Other Protein References for LOXL4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for LOXL4 Gene

Protein Domains for LOXL4 Gene

Suggested Antigen Peptide Sequences for LOXL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 SRCR domains.
  • Belongs to the lysyl oxidase family.
  • Contains 4 SRCR domains.
  • Belongs to the lysyl oxidase family.
genes like me logo Genes that share domains with LOXL4: view

No data available for Gene Families for LOXL4 Gene

Function for LOXL4 Gene

Molecular function for LOXL4 Gene

UniProtKB/Swiss-Prot Function:
May modulate the formation of a collagenous extracellular matrix

Enzyme Numbers (IUBMB) for LOXL4 Gene

Gene Ontology (GO) - Molecular Function for LOXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004720 protein-lysine 6-oxidase activity IEA --
GO:0005044 scavenger receptor activity IEA --
GO:0005507 copper ion binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor --
genes like me logo Genes that share ontologies with LOXL4: view

Animal Model Products

miRNA for LOXL4 Gene

miRTarBase miRNAs that target LOXL4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LOXL4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for LOXL4 Gene

Localization for LOXL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LOXL4 Gene

Secreted, extracellular space.

Subcellular locations from

Jensen Localization Image for LOXL4 Gene COMPARTMENTS Subcellular localization image for LOXL4 gene
Compartment Confidence
extracellular 3
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LOXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0043235 receptor complex IDA 23382219
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with LOXL4: view

Pathways for LOXL4 Gene

genes like me logo Genes that share pathways with LOXL4: view

Gene Ontology (GO) - Biological Process for LOXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with LOXL4: view

Drugs for LOXL4 Gene

(1) HMDB Compounds for LOXL4 Gene

Compound Synonyms Cas Number PubMed IDs
  • Copper

(3) Novoseek inferred chemical compound relationships for LOXL4 Gene

Compound -log(P) Hits PubMed IDs
amine 61.7 6
copper 31.6 1
cysteine 16.4 3
genes like me logo Genes that share compounds with LOXL4: view

Transcripts for LOXL4 Gene

mRNA/cDNA for LOXL4 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LOXL4 Gene

Lysyl oxidase-like 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LOXL4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LOXL4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2: - - - -
SP4: - - - -
SP5: -

Relevant External Links for LOXL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LOXL4 Gene

mRNA expression in normal human tissues for LOXL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for LOXL4 Gene

This gene is overexpressed in Islet of Langerhans (36.2) and Bone marrow mesenchymal stem cell (18.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LOXL4 Gene

SOURCE GeneReport for Unigene cluster for LOXL4 Gene Hs.306814

mRNA Expression by UniProt/SwissProt for LOXL4 Gene

Tissue specificity: Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage
genes like me logo Genes that share expressions with LOXL4: view

Expression partners for LOXL4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LOXL4 Gene

Orthologs for LOXL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for LOXL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOXL4 35
  • 88.53 (n)
  • 88.57 (a)
LOXL4 36
  • 88 (a)
(Canis familiaris)
Mammalia LOXL4 35
  • 88.83 (n)
  • 89.1 (a)
LOXL4 36
  • 88 (a)
(Mus musculus)
Mammalia Loxl4 35
  • 85.36 (n)
  • 86.9 (a)
Loxl4 16
Loxl4 36
  • 87 (a)
(Pan troglodytes)
Mammalia LOXL4 35
  • 99.69 (n)
  • 99.74 (a)
LOXL4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Loxl4 35
  • 85.54 (n)
  • 85.98 (a)
(Monodelphis domestica)
Mammalia LOXL4 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia LOXL4 36
  • 63 (a)
(Gallus gallus)
Aves LOXL4 35
  • 71.99 (n)
  • 68.49 (a)
LOXL4 36
  • 66 (a)
(Anolis carolinensis)
Reptilia LOXL4 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia loxl4 35
  • 65.42 (n)
  • 65.79 (a)
(Danio rerio)
Actinopterygii loxl4 35
  • 62.54 (n)
  • 60.25 (a)
loxl4 36
  • 51 (a)
LOXL4 (2 of 2) 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta lox 37
  • 42 (a)
lox2 37
  • 40 (a)
Species with no ortholog for LOXL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LOXL4 Gene

Gene Tree for LOXL4 (if available)
Gene Tree for LOXL4 (if available)

Paralogs for LOXL4 Gene

Paralogs for LOXL4 Gene

(2) SIMAP similar genes for LOXL4 Gene using alignment to 1 proteins: Pseudogenes for LOXL4 Gene

genes like me logo Genes that share paralogs with LOXL4: view

Variants for LOXL4 Gene

Sequence variations from dbSNP and Humsavar for LOXL4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs729312 -- 98,258,993(-) GGCAT(C/T)CTGCA intron-variant
rs735116 -- 98,261,776(+) ACCCA(A/G)TGCTG intron-variant
rs746257 -- 98,262,226(-) ATCAC(C/T)TCCAC intron-variant
rs746969 -- 98,258,873(-) CAGAA(C/T)TGTAG intron-variant
rs912808 -- 98,269,688(-) CATGA(A/G)AGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LOXL4 Gene

Variant ID Type Subtype PubMed ID
nsv831954 CNV Loss 17160897
esv2739962 CNV Deletion 23290073
esv2676146 CNV Deletion 23128226

Relevant External Links for LOXL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LOXL4 Gene

Disorders for LOXL4 Gene

(5) Novoseek inferred disease relationships for LOXL4 Gene

Disease -log(P) Hits PubMed IDs
hnscc 64.9 6
carcinoma squamous cell 26.7 4
carcinoma 14.2 2
tumors 6.59 3
cancer 0 2

Relevant External Links for LOXL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LOXL4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for LOXL4 Gene

Publications for LOXL4 Gene

  1. A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain. (PMID: 11691588) Asuncion L. … Csiszar K. (Matrix Biol. 2001) 3 4 23
  2. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (PMID: 17287949) Akagawa H. … Inoue I. (Hum. Genet. 2007) 3 23 48
  3. Molecular cloning and biological activity of a novel lysyl oxidase- related gene expressed in cartilage. (PMID: 11292829) Ito H. … Nakamura T. (J. Biol. Chem. 2001) 2 3 4
  4. Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. (PMID: 11691589) Maeki J.M. … Kivirikko K.I. (Matrix Biol. 2001) 3 4 23
  5. Lysyl oxidase like 4, a novel target gene of TGF-beta1 signaling, can negatively regulate TGF-beta1-induced cell motility in PLC/PRF/5 hepatoma cells. (PMID: 18586005) Kim D.J. … Yeom Y.I. (Biochem. Biophys. Res. Commun. 2008) 3 23

Products for LOXL4 Gene

Sources for LOXL4 Gene

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