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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LOXL4 Gene

protein-coding   GIFtS: 57
GCID: GC10M099997

lysyl oxidase-like 4
 Explore 9 diseases affiliated with
LOXL4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LOXL4    

Aliases
for LOXL4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Lysyl Oxidase-Like 41 2     Lysyl Oxidase Homolog 42
LOXC1 2 3     Lysyl Oxidase Related C2
Lysyl Oxidase-Like Protein 42 3     Lysyl Oxidase-Like 4 Pseudogene2
Lysyl Oxidase-Related Protein C2 3     EC 1.4.3.-3
FLJ218891     EC 1.4.38

External Ids:    HGNC: 171711   Entrez Gene: 841712   Ensembl: ENSG000001381317   OMIM: 6073185   UniProtKB: Q96JB63   

Export aliases for LOXL4 gene to outside databases

Previous GC identifers: GC10M098900 GC10M099241 GC10M100138 GC10M099672 GC10M093632


Summaries
for LOXL4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for LOXL4:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the
biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first
step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus
end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.
The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor
suppression, cell growth control, and chemotaxis to each member of the family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LOXL4_HUMAN, Q96JB6
Function: May modulate the formation of a collagenous extracellular matrix

Gene Wiki entry for LOXL4


Genomic Views
for LOXL4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LOXL4 gene promoter:
         GR   RelA   NF-kappaB   Tal-1beta   NF-AT   Evi-1   STAT3   GR-alpha   ITF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LOXL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for LOXL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LOXL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24

LOXL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOXL4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M099997:  view genomic region     (about GC identifiers)

Start:
 100,007,443 bp from pter      End:
 100,028,007 bp from pter
Size:
 20,565 bases      Orientation:
 minus strand

Proteins
for LOXL4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LOXL4_HUMAN, Q96JB6 (See protein sequence)
Recommended Name: Lysyl oxidase homolog 4 precursor  
Size: 756 amino acids; 84483 Da
Cofactor: Copper (By similarity)
Cofactor: Contains 1 lysine tyrosylquinone (By similarity)
Subcellular location: Secreted, extracellular space (Potential)
Sequence caution: Sequence=AAH07522.1; Type=Erroneous initiation;
Secondary accessions: Q5W0B3 Q96DY1 Q96PC0 Q9H6T5

Explore the universe of human proteins at neXtProt for LOXL4: NX_Q96JB6

Post-translational modifications:

  • The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a
    • topaquinone produced by oxidation of tyrosine1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96JB6

    • 4/8 DME Specific Peptides for LOXL4 (Q96JB6) (see all 8)
     ESDFSNN  RRLLRFS  CHRHYHS  IHLSEVRC 

    LOXL4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_115587.6  
    ENSEMBL proteins: 
     ENSP00000260702  
    Reactome Protein details: Q96JB6
    Human Recombinant Protein Products: 
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    Novus Biologicals LOXL4 Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for LOXL4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--
    GO:0016020membrane IEA--


    LOXL4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for LOXL4

    Protein Domains /
    Families
    for LOXL4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LOXL4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001190 Srcr_rcpt
     IPR001695 Lysyl_oxidase
     IPR017448 Srcr_rcpt-rel
     IPR019828 Lysyl_oxidase_CS

    Graphical View of Domain Structure for InterPro Entry Q96JB6

    ProtoNet protein and cluster: Q96JB6

    2 Blocks protein families:
    IPB001190 Speract/scavenger receptor
    IPB001695 Lysyl oxidase


    UniProtKB/Swiss-Prot: LOXL4_HUMAN, Q96JB6
    Similarity: Belongs to the lysyl oxidase family
    Similarity: Contains 4 SRCR domains


    Function
    for LOXL4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LOXL4_HUMAN, Q96JB6
    Function: May modulate the formation of a collagenous extracellular matrix

    Enzyme Numbers (IUBMB): EC 1.4.3.-1 EC 1.4.32

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LOXL4
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate LOXL4 (see all 43):
    hsa-miR-193a-3p hsa-let-7d hsa-miR-29a hsa-let-7g hsa-miR-133a hsa-let-7a hsa-miR-330-3p hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmid: LOXL4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LOXL4 (see all 7)
    OriGene shRNA RFP: LOXL4
    OriGene siRNA: LOXL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LOXL4

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOXL4 

    Cell Line
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    Search LifeMap BioReagents cell lines for LOXL4

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004720protein-lysine 6-oxidase activity IEA--
    GO:0005044scavenger receptor activity IEA--
    GO:0005507copper ion binding IEA--
    GO:0005515protein binding IPI19060904


    LOXL4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for LOXL4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Collagen formation
    		Collagen formation1.00
    		Extracellular matrix organization0.54
    		Assembly of collagen fibrils and other multimeric structures0.65
    2Elastic fibre formation
    		Elastic fibre formation1.00
    3Crosslinking of collagen fibrils
    		Crosslinking of collagen fibrils1.00
    4Tropoelastin associates with microfibrils
    		Elastin cross-linking by lysyl oxidase0.55

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for LOXL4 (see all 6)
        Extracellular matrix organization
    Assembly of collagen fibrils and other multimeric structures
    Crosslinking of collagen fibrils
    Elastic fibre formation
    Collagen formation



    LOXL4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LOXL4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/10 Interacting proteins for LOXL4 (Q96JB61, 2, 3 ENSP000002607024) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156451, 2, 3, ENSP000001663454EBI-749562,EBI-358993 MINT-67547 I2D: score=5 STRING: ENSP00000166345
    COL2A1P024583, ENSP000003698894I2D: score=1 STRING: ENSP00000369889
    APOEP026493I2D: score=1 
    CDC37Q165433I2D: score=1 
    ECSITQ9BQ953I2D: score=1 
    About this table

    Drugs & Compounds
    for LOXL4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LOXL4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LOXL4

    1 HMDB Compound for LOXL4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    3 Novoseek chemical compound relationships for LOXL4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amine 61.7 7 14551188 (4), 19724858 (1), 18949373 (1)
    copper 31.6 1 12686136 (1)
    cysteine 16.4 3 14551188 (2), 11691588 (1)

    Search CenterWatch for drugs/clinical trials and news about LOXL4 

    Transcripts
    for LOXL4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LOXL4 gene: 
    NM_032211.6  

    Unigene Clusters for LOXL4:

    Lysyl oxidase-like 4
    Hs.306814  [show with all ESTs], Hs.671890  [show with all ESTs]
    Unigene Representative Sequences: BC013153, BC015656
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260702(uc001kpa.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: LOXL4
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LOXL4
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate LOXL4 (see all 43):
    hsa-miR-193a-3p hsa-let-7d hsa-miR-29a hsa-let-7g hsa-miR-133a hsa-let-7a hsa-miR-330-3p hsa-miR-223*
    SwitchGear 3'UTR luciferase reporter plasmid: LOXL4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LOXL4 (see all 7)
    OriGene shRNA RFP: LOXL4
    OriGene siRNA: LOXL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LOXL4
    Clone
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    GenScript: all cDNA clones in your preferred vector: LOXL4 (NM_032211)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LOXL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LOXL4

    Additional cDNA sequence: BC015656.2 

    8 DOTS entries:

    DT.412273  DT.100688750  DT.101967422  DT.75179047  DT.121282903  DT.121282906  DT.121282907  DT.95119001 

    2 AceView cDNA sequences:

    BG761124 BC015656 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LOXL4    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                          -                                                                                                                     
    SP2:                          -           -     -     -                                                                                             
    SP3:                                                                                                                                                
    SP4:        -     -     -     -                                                                                                                     
    SP5:                                                                          -                                                                     


    ECgene alternative splicing isoforms for LOXL4

    Expression
    for LOXL4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LOXL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTTCTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    LOXL4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungTracheaBasal CellsLung
    BoneThoracic RibBone
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See LOXL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LOXL4

    SOURCE GeneReport for Unigene clusters: Hs.306814 Hs.671890

    UniProtKB/Swiss-Prot: LOXL4_HUMAN, Q96JB6
    Tissue specificity: Expressed in many tissues, the highest levels among the tissues studied being in the skeletal
    muscle, testis and pancreas. Expressed in cartilage

        SABiosciences Custom PCR Arrays for LOXL4
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    In Situ
    Assay Products:     
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    Orthologs
    for LOXL4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LOXL4 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOXL41 lysyl oxidase-like 4 71.81(n)
    68.19(a)    		   769927  XM_001233239.2  XP_001233240.2 
    lizard
    (Anolis carolinensis)    		 Reptilia LOXL46
    LOXL26
    		 --
    		 66(a)
    49(a)
    		 1 ↔ 1
    possible ortholog
    		 3(38824602-38834920)
    GL343754.1(4719-48387)
    zebrafish
    (Danio rerio)    		 Actinopterygii loxl41 lysyl oxidase-like 4 62.08(n)
    59.7(a)    		   100320658  XM_002664212.2  XP_002664258.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta lox3 protein-lysine 6-oxidase 42(a)
    (best of 2)    		   100C4   --


    ENSEMBL Gene Tree for LOXL4 (if available)
    TreeFam Gene Tree for LOXL4 (if available) 

    Paralogs
    for LOXL4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LOXL4 gene
    LOXL22  CD62  CD163L12  LOXL32  CD1632  SSC5D2  PRSS122  CD5L2  
    LOX2  SRCRB4D2  LOC6192072  LOXL12  
    2 SIMAP similar genes for LOXL4 using alignment to 1 protein entry:     LOXL4_HUMAN:
    LOXL2    LOXL3

    LOXL4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LOXL4
    PGOHUM00000238604


    Genomic Variants
    for LOXL4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/478 NCBI SNPs in LOXL4 are shown (see all 478)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1408270261,2
    		--100006972(+) GCTCCC/GTCTGC 1 -- ds50010--------
    rs1925177391,2
    		--100006987(+) TGAAGC/GAGATG 1 -- ds50010--------
    rs1501505361,2
    		--100007062(+) TTCCCC/TGGAAC 1 -- ds50010--------
    rs1855139961,2
    		--100007063(+) TCCCCA/GGAACA 1 -- ds50010--------
    rs1154700631,2
    		F,--100007123(+) TCTTGT/CGATGT 1 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1384327651,2
    		--100007185(+) GCTTCA/GCAGCC 1 -- ds50010--------
    rs49191891,2
    		C,F,H,--100007243(+) TCCTTC/TACCCC 1 -- ds500117Minor allele frequency- T:0.12NS NA WA CSA EA 1266
    rs118169981,2
    		C,F,H,--100007362(+) GCCCTG/CTGTAT 1 -- ds50015Minor allele frequency- C:0.22NA WA 244
    rs1893702611,2
    		--100007381(+) CTGGCC/TCCATG 1 -- ds50010--------
    rs1492778351,2
    		--100007433(+) AATCAC/GAGCTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for LOXL4 (100007443 - 100028007 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LOXL4: --

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    Disorders / Diseases
    for LOXL4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LOXL4 for disorders           About GeneDecksing

    OMIM gene information: 607318    OMIM disorders: --

    9 diseases for LOXL4:    About MalaCards
    intracranial aneurysm    squamous cell carcinoma    scoliosis    alzheimer's disease
    endometriosis    infertility    carcinoma    breast cancer
    adenocarcinoma

    5 Novoseek disease relationships for LOXL4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hnscc 64.9 9 18949373 (3), 17354256 (3)
    carcinoma squamous cell 26.7 6 18949373 (2), 17354256 (2)
    carcinoma 14.2 3 12894545 (1), 17354256 (1)
    tumors 6.59 4 19015874 (1), 19724858 (1), 18949373 (1)
    cancer 0 2 19015874 (1), 18202753 (1)

    Human Genome Epidemiology (HuGE) Navigator: LOXL4 (2 documents)

    Export disorders for LOXL4 gene to outside databases

    Publications
    for LOXL4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LOXL4 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with LOXL4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and biological activity of a novel lysyl oxidase- related gene expressed in cartilage. (PubMed id 11292829)1, 2, 3 Ito H....Nakamura T. (2001)
    2. A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain. (PubMed id 11691588)1, 2, 9 Asuncion L....Csiszar K. (2001)
    3. Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. (PubMed id 11691589)1, 2, 9 Maeki J.M.... Kivirikko K.I. (2001)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer. (PubMed id 18202753)1, 9 Weise J.B....Gorogh T. (2008)
    7. Lysyl oxidase like 4, a novel target gene of TGF-beta1 signaling, can negatively regulate TGF-beta1-induced cell motility in PLC/PRF/5 hepatoma cells. (PubMed id 18586005)1, 9 Kim D.J....Yeom Y.I. (2008)
    8. Functional analysis of the 5' flanking domain of the LOXL4 gene in head and neck squamous cell carcinoma cells. (PubMed id 18949373)1, 9 Gorogh T....Csiszar K. (2008)
    9. Expression and purification of enzymatically active forms of the human lysyl oxidase-like protein 4. (PubMed id 14551188)1, 9 Kim M.S....Kim Y. (2003)
    10. Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities. (PubMed id 19015874)1, 9 Sebban S....Reich R. (2009)

    External Searches for LOXL4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LOXL4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84171 HGNC: 17171 AceView: LOXL4.1 Ensembl:ENSG00000138131 euGenes: HUgn84171
    ECgene: LOXL4 H-InvDB: LOXL4

    Other Databases showing LOXL4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LOXL4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LOXL4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LOXL4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for LOXL4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LOXL4 gene:
    Search GeneIP for patents involving LOXL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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