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LOXL3 Gene

protein-coding   GIFtS: 60
GCID: GC02M074760

Lysyl Oxidase-Like 3

  Search for LOXL3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysyl Oxidase-Like 31 2     EC 1.4.3.-3
Lysyl Oxidase-Like Protein 32 3     EC 1.4.38
LOXL2 3     EC 1.4.3.138
Lysyl Oxidase Homolog 32     

External Ids:    HGNC: 138691   Entrez Gene: 846952   Ensembl: ENSG000001153187   OMIM: 6071635   UniProtKB: P582153   

Export aliases for LOXL3 gene to outside databases

Previous GC identifers: GC02M074897 GC02M074972 GC02M074717 GC02M074734 GC02M074671 GC02M074613 GC02M074496


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LOXL3 Gene:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to
the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the
first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the
C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain
this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation,
senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively
spliced transcript variants of this gene have been reported but their full-length nature has not been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for LOXL3 Gene:
LOXL3 (lysyl oxidase-like 3) is a protein-coding gene. GO annotations related to this gene include protein-lysine 6-oxidase activity and copper ion binding. An important paralog of this gene is LOXL2.

Gene Wiki entry for LOXL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the LOXL3 gene promoter:
         c-Fos   STAT1   AP-1   ATF-2   Nkx2-5   c-Jun   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLOXL3 promoter sequence
   Search Chromatin IP Primers for LOXL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LOXL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13

LOXL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOXL3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M074760:  view genomic region     (about GC identifiers)

Start:
74,759,541 bp from pter      End:
74,782,817 bp from pter
Size:
23,277 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LOXL3_HUMAN, P58215 (See protein sequence)
Recommended Name: Lysyl oxidase homolog 3 precursor  
Size: 753 amino acids; 83166 Da
Cofactor: Copper (By similarity)
Cofactor: Contains 1 lysine tyrosylquinone (By similarity)
Secondary accessions: D6W5J1 Q96RS1

Explore the universe of human proteins at neXtProt for LOXL3: NX_P58215

Explore proteomics data for LOXL3 at MOPED

Post-translational modifications: 

  • The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine
    with a topaquinone produced by oxidation of tyrosine1
  • Glycosylation2 at Asn111, Asn266, Asn390, Asn481, Asn625
  • Selected DME Specific Peptides for LOXL3 (P58215) (see all 8)
     RRLLRFS  ESDFTNN  YECANFG  DAGVRCN 


    See LOXL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276093.1  NP_001276094.1  NP_115992.1  

    ENSEMBL proteins: 
     ENSP00000264094   ENSP00000387103   ENSP00000377512   ENSP00000386696   ENSP00000386545  
     ENSP00000404026   ENSP00000398260  
    Reactome Protein details: P58215

    LOXL3 Human Recombinant Protein Products:

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    Novus Biologicals LOXL3 Protein
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    Cloud-Clone Corp. Proteins for LOXL3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001190 SRCR
     IPR001695 Lysyl_oxidase
     IPR017448 Srcr_rcpt-rel
     IPR019828 Lysyl_oxidase_CS

    Graphical View of Domain Structure for InterPro Entry P58215

    ProtoNet protein and cluster: P58215

    2 Blocks protein domains:
    IPB001190 Speract/scavenger receptor
    IPB001695 Lysyl oxidase


    UniProtKB/Swiss-Prot: LOXL3_HUMAN, P58215
    Similarity: Belongs to the lysyl oxidase family
    Similarity: Contains 4 SRCR domains


    Find genes that share domains with LOXL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 1.4.3.-1 EC 1.4.3.132 EC 1.4.32

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004720protein-lysine 6-oxidase activity NAS11284725
    GO:0005044scavenger receptor activity IEA--
    GO:0005507copper ion binding NAS11284725
    GO:0005515protein binding IPI16096638
    GO:0016641oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor ----
         
    Find genes that share ontologies with LOXL3           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for LOXL3:
     Decreased BPV1 E2 protein expr  Increased 8N DNA content  Increased HPV18 LCR reporter a  Increased cell number in G2M,  
     Increased circadian rhythm amp 

    Animal Models:
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    miRNA
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    hsa-miR-320a hsa-miR-3678-3p hsa-let-7d hsa-miR-875-5p hsa-miR-202 hsa-miR-486-3p hsa-let-7c hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidLOXL3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: LOXL3 (NM_032603)
    Sino Biological Human cDNA Clone for LOXL3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOXL3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LOXL3_HUMAN, P58215: Secreted, extracellular space (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    endoplasmic reticulum1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA11284725
    GO:0005615extracellular space IEA--
    GO:0005634nucleus TAS16096638
    GO:0016020membrane IEA--

    Find genes that share ontologies with LOXL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LOXL3 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen formation0.75
    Crosslinking of collagen fibrils0.00
    Assembly of collagen fibrils and other multimeric structures0.62
    2Elastic fibre formation
    Elastic fibre formation0.73
    3Degradation of the extracellular matrix
    Extracellular matrix organization0.34


    Find genes that share SuperPaths with LOXL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for LOXL3
        Crosslinking of collagen fibrils
    Elastic fibre formation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LOXL3
    Interactions:

        Search GeneGlobe Interaction Network for LOXL3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for LOXL3 (P582152, 3 ENSP000002640944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APMAPQ9HDC92, 3, ENSP000002174564MINT-65567 I2D: score=4 STRING: ENSP00000217456
    EGFL7Q9UHF13, ENSP000003078434I2D: score=1 STRING: ENSP00000307843
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001837epithelial to mesenchymal transition IDA16096638
    GO:0045892negative regulation of transcription, DNA-templated IDA16096638
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with LOXL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LOXL3

    1 HMDB Compound for LOXL3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--

    3 Novoseek inferred chemical compound relationships for LOXL3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amine 62.1 10 17018530 (3), 19724858 (1), 18949373 (1)
    quinone 41.1 2 12686136 (1)
    copper 36 5 17018530 (2), 12686136 (1)



    Find genes that share compounds with LOXL3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LOXL3 gene (3 alternative transcripts): 
    NM_001289164.1  NM_001289165.1  NM_032603.3  

    Unigene Cluster for LOXL3:

    Lysyl oxidase-like 3
    Hs.469045  [show with all ESTs]
    Unigene Representative Sequence: NM_032603
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470907(uc002smo.1) ENST00000264094(uc002smp.1 uc002smq.1)
    ENST00000409249 ENST00000393937 ENST00000409549(uc010ffm.1) ENST00000409986(uc010ffn.1)
    ENST00000481835 ENST00000420535 ENST00000413469 ENST00000484369
    miRNA
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    Block miRNA regulation of human, mouse, rat LOXL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LOXL3 (see all 28):
    hsa-miR-320a hsa-miR-3678-3p hsa-let-7d hsa-miR-875-5p hsa-miR-202 hsa-miR-486-3p hsa-let-7c hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidLOXL3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat LOXL3
      QuantiFast Probe-based Assays in human, mouse, rat LOXL3

    Additional mRNA sequence: 

    AF282619.1 AF284815.1 AF311313.1 AK309474.1 AK309478.1 BC033130.1 BC071865.1 DQ378059.1 

    17 DOTS entries:

    DT.95308530  DT.102843288  DT.100820650  DT.449699  DT.100820649  DT.100772913  DT.100037384  DT.91711475 
    DT.100757892  DT.100820656  DT.102843287  DT.87079417  DT.92040177  DT.99968275  DT.120975020  DT.120975094 
    DT.95148387 

    Selected AceView cDNA sequences (see all 73):

    AF284815 BX281893 AI567791 BQ774385 AA530866 AI611786 CA418900 BF592916 
    BQ772795 NM_032603 BC033130 BQ004230 AF311313 AF282619 BQ013587 CA423687 
    CA429334 BF114880 AI752772 CA449098 BE731785 AA625414 BX365178 BM989003 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LOXL3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
    SP1:        -                                                                                                         
    SP2:                                            -                 -     -                                             
    SP3:        -                 -     -     -     -                                                                     
    SP4:                                            -                                                                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for LOXL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LOXL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LOXL3 Expression
    About this image


    LOXL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Endochondral Facial Bones
     
     Limb (Muscoskeletal System)
             Autopod
    LOXL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LOXL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469045

    UniProtKB/Swiss-Prot: LOXL3_HUMAN, P58215
    Tissue specificity: Expressed in many tissues, the highest levels among the tissues studied being seen in the
    placenta, heart, ovary, testis, small intestine and spleen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOXL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LOXL3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Loxl31 , 5 lysyl oxidase-like 31, 5 87.83(n)1
    92.56(a)1
      6 (35.94 cM)5
    169501  NM_013586.41  NP_038614.21 
     830341735 
    chicken
    (Gallus gallus)
    Aves LOXL31 lysyl oxidase-like 3 72.51(n)
    75.1(a)
      425986  XM_423667.4  XP_423667.4 
    lizard
    (Anolis carolinensis)
    Reptilia LOXL36
    lysyl oxidase-like 3
    71(a)
    1 ↔ 1
    GL343867.1(70080-123318)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136062 Xenopus laevis transcribed sequence with weak similarity more 73.88(n)    BJ065778.1 
    zebrafish
    (Danio rerio)
    Actinopterygii loxl3a1 lysyl oxidase-like 3a 66.01(n)
    66.85(a)
      568839  NM_001199870.1  NP_001186799.1 


    ENSEMBL Gene Tree for LOXL3 (if available)
    TreeFam Gene Tree for LOXL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LOXL3 gene
    LOXL22  CD62  CD163L12  LOXL42  CD1632  SSC5D2  PRSS122  CD5L2  
    LOX2  SRCRB4D2  LOXL12  DMBT12  
    8 SIMAP similar genes for LOXL3 using alignment to 10 protein entries:     LOXL3_HUMAN (see all proteins):
    LOXL2    HHIPL1    LOXL4    LOX    CD6    LGALS3BP
    DMBT1    SSC5D

    Find genes that share paralogs with LOXL3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LOXL3
    PGOHUM00000234958


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LOXL3 (see all 533)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925837711,2
    --74630737(+) GTATTC/TTAGAA 1 -- ds50010--------
    rs1379801731,2
    --74630768(+) TAACAC/TTGTTT 1 -- ds50010--------
    rs1828981481,2
    --74630804(+) ACATCC/TTTTAT 1 -- ds50010--------
    rs792017921,2
    C,F--74630962(+) GCTAAT/CAGGGT 1 -- ds50011Minor allele frequency- C:0.08WA 118
    rs1874491051,2
    C--74630973(+) GATCTA/GTGTAC 1 -- ds50010--------
    rs1503574861,2
    C,F--74631024(+) TTTCCC/TGATGT 1 -- ds50011Minor allele frequency- T:0.00NA 4552
    rs1846767431,2
    C--74631125(+) GTGTGC/TATGTG 1 -- ds50010--------
    rs2003017641,2
    --74631151(+) TTGTAC/TTCCTT 1 -- ds50010--------
    rs1890645001,2
    C--74631158(+) CCTTCC/TTTTCT 1 -- ds50010--------
    rs1997962881,2
    C--74631169(+) CTCTGC/TCCATT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for LOXL3 (74759541 - 74782817 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LOXL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4166n71CNV Loss21882294
    dgv1199e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing LOXL3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607163    OMIM disorders: --


    Find genes that share disorders with LOXL3           About GenesLikeMe

    1 Novoseek inferred disease relationship for LOXL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.976 3 19015874 (1), 18949373 (1), 16096638 (1)

    Genetic Association Database (GAD): LOXL3
    Human Genome Epidemiology (HuGE) Navigator: LOXL3 (2 documents)

    Export disorders for LOXL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LOXL3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with LOXL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. (PubMed id 11386757)1, 2, 3, 9 Jourdan-Le Saux C.... Csiszar K. (Genomics 2001)
    2. Cloning and characterization of a fourth human lysyl oxidase isoenzyme. (PubMed id 11284725)1, 2, 9 Maki J.M. and Kivirikko K.I. (Biochem. J. 2001)
    3. Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3). (PubMed id 11334717)1, 2, 9 Huang Y....Mao Y. (Matrix Biol. 2001)
    4. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (PubMed id 17287949)1, 4, 9 Akagawa H....Inoue I. (Hum. Genet. 2007)
    5. A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity. (PubMed id 17018530)1, 9 Lee J.-E. and Kim Y. (J. Biol. Chem. 2006)
    6. Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities. (PubMed id 19015874)1, 9 Sebban S....Reich R. (Virchows Arch. 2009)
    7. Structural and functional diversity of lysyl oxidase and the LOX-like proteins. (PubMed id 12686136)1, 9 Molnar J....Csiszar K. (Biochim. Biophys. Acta 2003)
    8. Differential expression of the LOX family genes in human colorectal adenocarcinomas. (PubMed id 19724858)1, 9 Kim Y....Kim J.C. (Oncol. Rep. 2009)
    9. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. (PubMed id 16096638)1, 9 Peinado H.... Portillo F. (EMBO J. 2005)
    10. TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury. (PubMed id 23357697)1 Xie J....Zhao H. (J Biomech 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84695 HGNC: 13869 AceView: LOXL3 Ensembl:ENSG00000115318 euGenes: HUgn84695
    ECgene: LOXL3 H-InvDB: LOXL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LOXL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LOXL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LOXL3 gene:
    Search GeneIP for patents involving LOXL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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