Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LOXL3 Gene

Aliases for LOXL3 Gene

  • Lysyl Oxidase Like 3 2 3 5
  • Lysyl Oxidase-Like Protein 3 3 4
  • EC 1.4.3.13 4 58
  • LOXL 3 4
  • Lysyl Oxidase Homolog 3 3
  • Lysyl Oxidase-Like 3 2
  • EC 1.4.3.- 4
  • EC 1.4.3 58

External Ids for LOXL3 Gene

Previous GeneCards Identifiers for LOXL3 Gene

  • GC02M074897
  • GC02M074972
  • GC02M074717
  • GC02M074734
  • GC02M074671
  • GC02M074613
  • GC02M074760
  • GC02M074496

Summaries for LOXL3 Gene

Entrez Gene Summary for LOXL3 Gene

  • This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016]

GeneCards Summary for LOXL3 Gene

LOXL3 (Lysyl Oxidase Like 3) is a Protein Coding gene. Diseases associated with LOXL3 include Stickler Syndrome and Irregular Astigmatism. Among its related pathways are Elastic fibre formation and Collagen chain trimerization. GO annotations related to this gene include copper ion binding and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. An important paralog of this gene is LOXL2.

UniProtKB/Swiss-Prot for LOXL3 Gene

  • Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600).

  • Isoform 1: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed:17018530).

  • Isoform 2: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530).

Gene Wiki entry for LOXL3 Gene

Additional gene information for LOXL3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOXL3 Gene

Genomics for LOXL3 Gene

Regulatory Elements for LOXL3 Gene

Enhancers for LOXL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H074575 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -21.2 -21202 3 PKNOX1 MAX CEBPG ZBTB40 BATF RAD21 GATA3 POLR2A EED ETV6 DOK1 LOXL3 HTRA2 AUP1 DQX1 TLX2 PCGF1 LBX2 CCDC142 TTC31
GH02H074583 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12 -28.1 -28066 1 MAFG BACH1 JUNB DPF2 BATF JUND ZNF316 POLR2A FOS NFE2 LOXL3 DOK1 HTRA2 AUP1 TLX2 PCGF1 CCDC142 TTC31 DQX1 LBX2
GH02H074528 1.2 ENCODE 11.2 +25.6 25562 4 HDGF FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 ZNF143 LBX2 TTC31 CCDC142 PCGF1 DUSP11 MOB1A AUP1 MOGS MTHFD2 ENSG00000273245
GH02H074487 1.2 ENCODE dbSUPER 10.9 +65.5 65549 4 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 TCF12 ATF7 SP5 LBX2 AUP1 HTRA2 DQX1 MOGS TLX2 WBP1 DOK1 LOXL3 GC02P074500
GH02H074587 1.1 Ensembl ENCODE 11.1 -31.9 -31914 0 HDGF RB1 TBL1XR1 ARID4B ZNF2 RAD21 ZNF143 ATF7 RUNX3 THAP11 LBX2 DOK1 MRPL53 AUP1 HTRA2 PCGF1 DQX1 LOXL3 TTC31 CCDC142
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LOXL3 on UCSC Golden Path with GeneCards custom track

Promoters for LOXL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119187 1187 2201 HDGF PKNOX1 ATF1 YBX1 BRCA1 ZNF766 GLIS2 ELK1 ZNF207 KLF7

Genomic Location for LOXL3 Gene

Chromosome:
2
Start:
74,532,258 bp from pter
End:
74,555,887 bp from pter
Size:
23,630 bases
Orientation:
Minus strand

Genomic View for LOXL3 Gene

Genes around LOXL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOXL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOXL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOXL3 Gene

Proteins for LOXL3 Gene

  • Protein details for LOXL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58215-LOXL3_HUMAN
    Recommended name:
    Lysyl oxidase homolog 3
    Protein Accession:
    P58215
    Secondary Accessions:
    • D6W5J1
    • Q2EHP2
    • Q6IPL7
    • Q96RS1

    Protein attributes for LOXL3 Gene

    Size:
    753 amino acids
    Molecular mass:
    83166 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Cofactor:
    Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489;
    Quaternary structure:
    • Interacts with STAT3 (PubMed:28065600).

    Alternative splice isoforms for LOXL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LOXL3 Gene

Selected DME Specific Peptides for LOXL3 Gene

P58215:
  • DIDCQWIDITDV
  • ESDFTNN
  • GEGRVEVL
  • IHLSEVRC
  • RRLLRFS
  • YECANFG
  • DAGVRCN
  • NGTKVAEGHKASFCLEDTEC

Post-translational modifications for LOXL3 Gene

  • The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
  • Glycosylation at posLast=111111, Asn266, posLast=390390, posLast=481481, and posLast=625625
  • Modification sites at PhosphoSitePlus

Domains & Families for LOXL3 Gene

Gene Families for LOXL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LOXL3 Gene

Graphical View of Domain Structure for InterPro Entry

P58215

UniProtKB/Swiss-Prot:

LOXL3_HUMAN :
  • Belongs to the lysyl oxidase family.
Family:
  • Belongs to the lysyl oxidase family.
genes like me logo Genes that share domains with LOXL3: view

Function for LOXL3 Gene

Molecular function for LOXL3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.72 uM for STAT3 acetylated at Lys-685 (for deacetylation activity) {ECO:0000269 PubMed:28065600}; KM=1.59 uM for STAT3 acetylated at Lys-685 (for lysine 6- oxidase activity) {ECO:0000269 PubMed:28065600}; Note=kcat is 0.058 sec(-1) with STAT3 acetylated at Lys-685 (for deacetylation activity). kcat is 0.022 sec(-1) with STAT3 acetylated at Lys-685 (for lysine 6-oxidase activity). {ECO:0000269 PubMed:28065600};
UniProtKB/Swiss-Prot CatalyticActivity:
[Protein]-L-lysine + O(2) + H(2)O = [protein]-(S)-2-amino-6-oxohexanoate + NH(3) + H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
[protein]-N(6)-acetyl-L-lysine + O(2) + H(2)O = [protein]-(S)-2-amino-6-oxohexanoate + acetamide + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600).
UniProtKB/Swiss-Prot Function:
Isoform 1: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII (PubMed:17018530).
UniProtKB/Swiss-Prot Function:
Isoform 2: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530).

Enzyme Numbers (IUBMB) for LOXL3 Gene

Gene Ontology (GO) - Molecular Function for LOXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding ISS --
GO:0004720 protein-lysine 6-oxidase activity NAS 11284725
GO:0005044 scavenger receptor activity IEA --
GO:0005507 copper ion binding IEA,NAS 11284725
GO:0005515 protein binding IPI 16096638
genes like me logo Genes that share ontologies with LOXL3: view
genes like me logo Genes that share phenotypes with LOXL3: view

Animal Models for LOXL3 Gene

MGI Knock Outs for LOXL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for LOXL3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LOXL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LOXL3 Gene

Localization for LOXL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LOXL3 Gene

Secreted, extracellular space. Cytoplasm. Nucleus. Note=It is unclear how LOXL3 is both intracellular (cytoplasmic and nuclear) and extracellular: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, the intracellular location is clearly reported and at least another protein of the family (LOXL2) also has intracellular and extracellular localization despite the presence of a signal sequence (PubMed:28065600). {ECO:0000269 PubMed:28065600}.
Isoform 1: Secreted, extracellular space.
Isoform 2: Cytoplasm. Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LOXL3 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LOXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 11284725
GO:0005615 extracellular space ISS --
GO:0005634 nucleus TAS 16096638
GO:0005737 cytoplasm IDA,IEA 28065600
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LOXL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LOXL3 Gene

Pathways & Interactions for LOXL3 Gene

genes like me logo Genes that share pathways with LOXL3: view

Interacting Proteins for LOXL3 Gene

Gene Ontology (GO) - Biological Process for LOXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition IDA 16096638
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006954 inflammatory response ISS --
GO:0018057 peptidyl-lysine oxidation IDA 28065600
GO:0021510 spinal cord development ISS --
genes like me logo Genes that share ontologies with LOXL3: view

No data available for SIGNOR curated interactions for LOXL3 Gene

Drugs & Compounds for LOXL3 Gene

(1) Drugs for LOXL3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved Pharma 188

(2) Additional Compounds for LOXL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LOXL3: view

Transcripts for LOXL3 Gene

Unigene Clusters for LOXL3 Gene

Lysyl oxidase-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LOXL3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LOXL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: - - -
SP3: - - - - -
SP4: -
SP5:

Relevant External Links for LOXL3 Gene

GeneLoc Exon Structure for
LOXL3
ECgene alternative splicing isoforms for
LOXL3

Expression for LOXL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LOXL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LOXL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.0), Bone marrow mesenchymal stem cell (15.1), Serum (12.2), and Bone (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LOXL3 Gene



Protein tissue co-expression partners for LOXL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of LOXL3 Gene:

LOXL3

SOURCE GeneReport for Unigene cluster for LOXL3 Gene:

Hs.469045

mRNA Expression by UniProt/SwissProt for LOXL3 Gene:

P58215-LOXL3_HUMAN
Tissue specificity: Isoform 1: Predominantly detected in the heart, placenta, lung, and small intestine (PubMed:17018530). Isoform 2: Highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung (PubMed:17018530). In eye, present in all layers of corneas as well as in the limbus and conjunctiva (at protein level) (PubMed:26218558).
genes like me logo Genes that share expression patterns with LOXL3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOXL3 Gene

Orthologs for LOXL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LOXL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOXL3 34 33
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOXL3 34 33
  • 91.67 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOXL3 33 34
  • 91.24 (n)
mouse
(Mus musculus)
Mammalia Loxl3 16 34 33
  • 87.83 (n)
rat
(Rattus norvegicus)
Mammalia Loxl3 33
  • 87.78 (n)
oppossum
(Monodelphis domestica)
Mammalia LOXL3 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOXL3 33 34
  • 72.51 (n)
lizard
(Anolis carolinensis)
Reptilia LOXL3 34
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13606 33
zebrafish
(Danio rerio)
Actinopterygii loxl3a 33 34
  • 66.01 (n)
loxl3b 34
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta lox 35
  • 40 (a)
lox2 35
  • 40 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12248 33
Species where no ortholog for LOXL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LOXL3 Gene

ENSEMBL:
Gene Tree for LOXL3 (if available)
TreeFam:
Gene Tree for LOXL3 (if available)

Paralogs for LOXL3 Gene

Paralogs for LOXL3 Gene

Pseudogenes.org Pseudogenes for LOXL3 Gene

genes like me logo Genes that share paralogs with LOXL3: view

Variants for LOXL3 Gene

Sequence variations from dbSNP and Humsavar for LOXL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1057519080 Pathogenic 74,532,924(+) GGCAG(-/TGCAG)ATCCG nc-transcript-variant, downstream-variant-500B, reference, utr-variant-3-prime, frameshift-variant
rs767006508 Pathogenic 74,532,714(+) ACACC(A/G)GTGAG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs114661282 Likely benign 74,533,516(+) TGCTG(A/G)CATGG nc-transcript-variant, utr-variant-3-prime
rs71640295 Likely benign 74,533,369(+) GGGCT(A/C/G)TGGTC nc-transcript-variant, utr-variant-3-prime
rs71640296 Likely benign 74,533,428(+) ACAGA(A/T)ACTGA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LOXL3 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850

Variation tolerance for LOXL3 Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LOXL3 Gene

Human Gene Mutation Database (HGMD)
LOXL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LOXL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LOXL3 Gene

Disorders for LOXL3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for LOXL3 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
stickler syndrome
  • arthroophthalmopathy
irregular astigmatism
pediatric ependymoma
  • childhood ependymoma
autosomal recessive stickler syndrome
myopia
  • near vision
- elite association - COSMIC cancer census association via MalaCards
Search LOXL3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

LOXL3_HUMAN
  • Note=Defects in LOXL3 are found in a family with an autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence and sensorineural deafness (PubMed:25663169). Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate) (PubMed:25663169). The degree of hearing loss varies among affected individuals and may become more severe over time (PubMed:25663169). Syndrome expressivity is variable (PubMed:25663169). Ocular disorders include non-progressive myopia with associated chorioretinal degeneration (PubMed:25663169). Defects in LOXL3 are found in another family with early-onset high myopia (PubMed:26957899). The disease may be caused by mutations affecting the gene represented in this entry (PubMed:25663169, PubMed:26957899). {ECO:0000269 PubMed:25663169, ECO:0000269 PubMed:26957899}.

Relevant External Links for LOXL3

Genetic Association Database (GAD)
LOXL3
Human Genome Epidemiology (HuGE) Navigator
LOXL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LOXL3
genes like me logo Genes that share disorders with LOXL3: view

No data available for Genatlas for LOXL3 Gene

Publications for LOXL3 Gene

  1. Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. (PMID: 11386757) Jourdan-Le Saux C … Csiszar K (Genomics 2001) 2 3 4 22 60
  2. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (PMID: 17287949) Akagawa H … Inoue I (Human genetics 2007) 3 22 45 60
  3. A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity. (PMID: 17018530) Lee JE … Kim Y (The Journal of biological chemistry 2006) 3 4 22 60
  4. Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3). (PMID: 11334717) Huang Y … Mao Y (Matrix biology : journal of the International Society for Matrix Biology 2001) 3 4 22 60
  5. Cloning and characterization of a fourth human lysyl oxidase isoenzyme. (PMID: 11284725) Mäki JM … Kivirikko KI (The Biochemical journal 2001) 3 4 22 60

Products for LOXL3 Gene

Sources for LOXL3 Gene

Content
Loading form....