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Aliases for LOXL3 Gene

Aliases for LOXL3 Gene

  • Lysyl Oxidase Like 3 2 3 5
  • Lysyl Oxidase-Like Protein 3 3 4
  • Lysyl Oxidase-Like 3 2 3
  • LOXL 3 4
  • EC 1.4.3.13 63
  • EC 1.4.3.- 4
  • EC 1.4.3 63

External Ids for LOXL3 Gene

Previous GeneCards Identifiers for LOXL3 Gene

  • GC02M074897
  • GC02M074972
  • GC02M074717
  • GC02M074734
  • GC02M074671
  • GC02M074613
  • GC02M074760
  • GC02M074496

Summaries for LOXL3 Gene

Entrez Gene Summary for LOXL3 Gene

  • This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for LOXL3 Gene

LOXL3 (Lysyl Oxidase Like 3) is a Protein Coding gene. Diseases associated with LOXL3 include fibrochondrogenesis 2 and irregular astigmatism. Among its related pathways are Degradation of the extracellular matrix and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include copper ion binding and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. An important paralog of this gene is LOXL1.

UniProtKB/Swiss-Prot for LOXL3 Gene

  • Both isoforms function as amine oxidases toward elastin and different types of collagens. Isoform 1 shows the highest activity toward collagen type VIII, while Isoform 2 presents the highest activity toward collagen type IV.

Gene Wiki entry for LOXL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOXL3 Gene

Genomics for LOXL3 Gene

Regulatory Elements for LOXL3 Gene

Promoters for LOXL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LOXL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LOXL3 Gene

Chromosome:
2
Start:
74,532,258 bp from pter
End:
74,555,887 bp from pter
Size:
23,630 bases
Orientation:
Minus strand

Genomic View for LOXL3 Gene

Genes around LOXL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOXL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOXL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOXL3 Gene

Proteins for LOXL3 Gene

  • Protein details for LOXL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58215-LOXL3_HUMAN
    Recommended name:
    Lysyl oxidase homolog 3
    Protein Accession:
    P58215
    Secondary Accessions:
    • D6W5J1
    • Q2EHP2
    • Q6IPL7
    • Q96RS1

    Protein attributes for LOXL3 Gene

    Size:
    753 amino acids
    Molecular mass:
    83166 Da
    Cofactor:
    Name=Cu cation; Xref=ChEBI:CHEBI:23378;
    Cofactor:
    Name=lysine tyrosylquinone residue; Xref=ChEBI:CHEBI:20489;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LOXL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LOXL3 Gene

Proteomics data for LOXL3 Gene at MOPED

Selected DME Specific Peptides for LOXL3 Gene

Post-translational modifications for LOXL3 Gene

  • The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
  • Glycosylation at Asn 111, Asn 266, Asn 390, Asn 481, and Asn 625
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for LOXL3 Gene

Protein Domains for LOXL3 Gene

Suggested Antigen Peptide Sequences for LOXL3 Gene

Graphical View of Domain Structure for InterPro Entry

P58215

UniProtKB/Swiss-Prot:

LOXL3_HUMAN :
  • Contains 4 SRCR domains.
  • Belongs to the lysyl oxidase family.
Domain:
  • Contains 4 SRCR domains.
Family:
  • Belongs to the lysyl oxidase family.
genes like me logo Genes that share domains with LOXL3: view

No data available for Gene Families for LOXL3 Gene

Function for LOXL3 Gene

Molecular function for LOXL3 Gene

UniProtKB/Swiss-Prot Function:
Both isoforms function as amine oxidases toward elastin and different types of collagens. Isoform 1 shows the highest activity toward collagen type VIII, while Isoform 2 presents the highest activity toward collagen type IV.

Enzyme Numbers (IUBMB) for LOXL3 Gene

Gene Ontology (GO) - Molecular Function for LOXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
GO:0005507 copper ion binding IEA,NAS 11284725
GO:0005515 protein binding IPI 16096638
genes like me logo Genes that share ontologies with LOXL3: view
genes like me logo Genes that share phenotypes with LOXL3: view

Animal Models for LOXL3 Gene

MGI Knock Outs for LOXL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for LOXL3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LOXL3 Gene

Localization for LOXL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LOXL3 Gene

Isoform 1: Secreted, extracellular space.
Isoform 2: Cytoplasm. Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LOXL3 Gene COMPARTMENTS Subcellular localization image for LOXL3 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LOXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LOXL3: view

Pathways & Interactions for LOXL3 Gene

genes like me logo Genes that share pathways with LOXL3: view

Interacting Proteins for LOXL3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264094%0d%0a9606.ENSP00000357644%0d%0a9606.ENSP00000217456%0d%0a
Selected Interacting proteins: ENSP00000264094 P58215-LOXL3_HUMAN for LOXL3 Gene via STRING I2D MINT

Gene Ontology (GO) - Biological Process for LOXL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001837 epithelial to mesenchymal transition IDA 16096638
GO:0045892 negative regulation of transcription, DNA-templated IDA 16096638
genes like me logo Genes that share ontologies with LOXL3: view

No data available for SIGNOR curated interactions for LOXL3 Gene

Drugs & Compounds for LOXL3 Gene

(1) Drugs for LOXL3 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Pharma 158

(2) Additional Compounds for LOXL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LOXL3: view

Transcripts for LOXL3 Gene

Unigene Clusters for LOXL3 Gene

Lysyl oxidase-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LOXL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: - - -
SP3: - - - - -
SP4: -
SP5:

Relevant External Links for LOXL3 Gene

GeneLoc Exon Structure for
LOXL3
ECgene alternative splicing isoforms for
LOXL3

Expression for LOXL3 Gene

mRNA expression in normal human tissues for LOXL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LOXL3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.0), Bone marrow mesenchymal stem cell (15.1), Serum (12.2), and Bone (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LOXL3 Gene



SOURCE GeneReport for Unigene cluster for LOXL3 Gene Hs.469045

mRNA Expression by UniProt/SwissProt for LOXL3 Gene

P58215-LOXL3_HUMAN
Tissue specificity: Isoform 1 ia predominantly detected in the heart, placenta, lung, and small intestine, while isoform 2 is more highly detected in the kidney, pancreas, spleen, and thymus, and is absent in lung.
genes like me logo Genes that share expression patterns with LOXL3: view

Protein tissue co-expression partners for LOXL3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LOXL3 Gene

Orthologs for LOXL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LOXL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOXL3 36
  • 99 (a)
OneToOne
LOXL3 35
  • 99.56 (n)
  • 99.34 (a)
cow
(Bos Taurus)
Mammalia LOXL3 36
  • 96 (a)
OneToOne
LOXL3 35
  • 91.67 (n)
  • 96.01 (a)
dog
(Canis familiaris)
Mammalia LOXL3 35
  • 91.24 (n)
  • 95.35 (a)
LOXL3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Loxl3 36
  • 93 (a)
OneToOne
Loxl3 16
Loxl3 35
  • 87.83 (n)
  • 92.56 (a)
oppossum
(Monodelphis domestica)
Mammalia LOXL3 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Loxl3 35
  • 87.78 (n)
  • 92.43 (a)
chicken
(Gallus gallus)
Aves LOXL3 35
  • 72.51 (n)
  • 75.1 (a)
LOXL3 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LOXL3 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13606 35
zebrafish
(Danio rerio)
Actinopterygii loxl3a 35
  • 66.01 (n)
  • 66.85 (a)
loxl3a 36
  • 65 (a)
OneToMany
loxl3b 36
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta lox 37
  • 40 (a)
lox2 37
  • 40 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12248 35
Species with no ortholog for LOXL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LOXL3 Gene

ENSEMBL:
Gene Tree for LOXL3 (if available)
TreeFam:
Gene Tree for LOXL3 (if available)

Paralogs for LOXL3 Gene

Paralogs for LOXL3 Gene

Pseudogenes.org Pseudogenes for LOXL3 Gene

genes like me logo Genes that share paralogs with LOXL3: view

Variants for LOXL3 Gene

Sequence variations from dbSNP and Humsavar for LOXL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17010021 - 74,534,412(+) GAAGA(A/T)GTCCA reference, missense
rs715407 -- 74,538,566(-) CTGGG(A/C)TCCTT intron-variant
rs6707302 -- 74,534,295(+) GTGGT(C/T)CACTT intron-variant
rs12104595 -- 74,541,090(+) ctgta(C/T)tgaac intron-variant
rs11687030 -- 74,544,828(+) AATTG(G/T)ATCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LOXL3 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
dgv4166n71 CNV Loss 21882294

Variation tolerance for LOXL3 Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LOXL3 Gene

HapMap Linkage Disequilibrium report
LOXL3
Human Gene Mutation Database (HGMD)
LOXL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LOXL3 Gene

Disorders for LOXL3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for LOXL3 Gene - From: GeneTests, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search LOXL3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LOXL3

Genetic Association Database (GAD)
LOXL3
Human Genome Epidemiology (HuGE) Navigator
LOXL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LOXL3
genes like me logo Genes that share disorders with LOXL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LOXL3 Gene

Publications for LOXL3 Gene

  1. Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. (PMID: 11386757) Jourdan-Le Saux C. … Csiszar K. (Genomics 2001) 2 3 4 23 67
  2. Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities. (PMID: 19015874) Sebban S. … Reich R. (Virchows Arch. 2009) 3 23
  3. Differential expression of the LOX family genes in human colorectal adenocarcinomas. (PMID: 19724858) Kim Y. … Kim J.C. (Oncol. Rep. 2009) 3 23
  4. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (PMID: 17287949) Akagawa H. … Inoue I. (Hum. Genet. 2007) 3 23
  5. A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity. (PMID: 17018530) Lee J.-E. … Kim Y. (J. Biol. Chem. 2006) 3 23

Products for LOXL3 Gene

Sources for LOXL3 Gene

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