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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LOXL2 Gene

protein-coding   GIFtS: 69
GCID: GC08M023210

Lysyl Oxidase-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysyl Oxidase-Like 21 2     WS9-142
Lysyl Oxidase-Like Protein 22 3     Lysyl Oxidase Homolog 22
Lysyl Oxidase-Related Protein 22 3     Lysyl Oxidase Related 22
Lysyl Oxidase-Related Protein WS9-142 3     EC 1.4.3.133
LOR22     EC 1.4.38

External Ids:    HGNC: 66661   Entrez Gene: 40172   Ensembl: ENSG000001340137   OMIM: 6066635   UniProtKB: Q9Y4K03   

Export aliases for LOXL2 gene to outside databases

Previous GC identifers: GC08U990046 GC08M023508 GC08M022974 GC08M023176 GC08M021700


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LOXL2 Gene:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to
the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the
first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the
C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain
this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation,
senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. (provided by
RefSeq, Jul 2008)

GeneCards Summary for LOXL2 Gene: 
LOXL2 (lysyl oxidase-like 2) is a protein-coding gene. Diseases associated with LOXL2 include wilson disease, and malignant peripheral nerve sheath tumor, and among its related super-pathways are Collagen formation and Molecules associated with elastic fibres. GO annotations related to this gene include electron carrier activity and chromatin binding. An important paralog of this gene is CD6.

UniProtKB/Swiss-Prot: LOXL2_HUMAN, Q9Y4K0
Function: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to
the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of
extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to
fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV
scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of
trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved
in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of
E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following
hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting
that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by
regulating expression of factors that control chondrocyte differentiation

Gene Wiki entry for LOXL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LOXL2 gene promoter:
         HFH-3   AML1a   FOXD3   RelA   CUTL1   LCR-F1   Tal-1beta   FOXI1   c-Myb   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLOXL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LOXL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LOXL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

LOXL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOXL2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M023210:  view genomic region     (about GC identifiers)

Start:
23,154,410 bp from pter      End:
23,282,841 bp from pter
Size:
128,432 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LOXL2_HUMAN, Q9Y4K0 (See protein sequence)
Recommended Name: Lysyl oxidase homolog 2 precursor  
Size: 774 amino acids; 86725 Da
Cofactor: Copper (By similarity)
Cofactor: Contains 1 lysine tyrosylquinone (By similarity)
Subunit: Component of some chromatin repressor complex. Interacts with SNAI1
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane (By similarity).
Nucleus. Chromosome. Note=Associated with chromatin. It is unclear how LOXL2 is nuclear: it contains a clear
signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed
the intracellular location and its key role in transcription regulation
Miscellaneous: Its overexpression in a number of cancer and its ability to promote epithelial to mesenchymal
transition suggest that LOXL2 might play a role in tumor progression: expression is correlated with metastasis
and decreased survival in patients with aggressive breast cancer (PubMed:21732535). Allosteric inhibition by
AB0023 inhibits formation of the tumor microenvironment and reduces metastatic tumor burden in xenograft models
(PubMed:20818376 and PubMed:21732535). However, inhibiting the enzyme activity of LOXL2 may not be sufficient,
since mutants that lack enzyme activity or inhibition of the activity by AB0023 antibody does not prevent
inhibition of the differentiation of keratinocytes, thereby promoting development of squamous cell carcinomas
(PubMed:22157764)
Sequence caution: Sequence=AAD34343.1; Type=Erroneous termination; Positions=775; Note=Translated as stop;
Secondary accessions: B2R5Q0 Q53HV3 Q9BW70 Q9Y5Y8

Explore the universe of human proteins at neXtProt for LOXL2: NX_Q9Y4K0

Explore proteomics data for LOXL2 at MOPED 

Post-translational modifications:

  • UniProtKB: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine
    with a topaquinone produced by oxidation of tyrosine
  • UniProtKB: N-glycosylated. N-glycosylation on Asn-455 and Asn-644 may be essential for proper folding and secretion; may be
    composed of a fucosylated carbohydrates attached to a trimannose N-linked glycan core
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4K0

  • 4/9 DME Specific Peptides for LOXL2 (Q9Y4K0) (see all 9)
     DAGVRCN  RRLLRFS  YECANFG  CHRHYHS 

    LOXL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LOXL2 Protein Expression
    REFSEQ proteins: NP_002309.1  
    ENSEMBL proteins: 
     ENSP00000373783   ENSP00000473322   ENSP00000427907   ENSP00000427826   ENSP00000427883  
     ENSP00000429778   ENSP00000430519   ENSP00000428497   ENSP00000428933  
    Reactome Protein details: Q9Y4K0
    Human Recombinant Protein Products for LOXL2: 
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    R&D Systems Recombinant & Natural Proteins for LOXL2 (Lysyl Oxidase Homolog 2/LOXL2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for LOXL2
    OriGene Custom MassSpec 
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    Novus Biologicals LOXL2 Protein
    Novus Biologicals LOXL2 Lysate
    Sino Biological Recombinant Protein for LOXL2
    Sino Biological Cell Lysate for LOXL2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LOXL2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane ISS--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus TAS16096638
    GO:0005694chromosome IEA--
    GO:0016020membrane IEA--

    LOXL2 for ontologies           About GeneDecksing



    LOXL2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for LOXL2
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    ThermoFisher Antibodies for LOXL2
    LSBio Antibodies in human, mouse, rat for LOXL2 

    Assay Products for LOXL2: 
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    Cloud-Clone Corp. ELISAs for LOXL2 
    Cloud-Clone Corp. CLIAs for LOXL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001190 Srcr_rcpt
     IPR001695 Lysyl_oxidase
     IPR017448 Srcr_rcpt-rel
     IPR019828 Lysyl_oxidase_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y4K0

    ProtoNet protein and cluster: Q9Y4K0

    2 Blocks protein domains:
    IPB001190 Speract/scavenger receptor
    IPB001695 Lysyl oxidase


    UniProtKB/Swiss-Prot: LOXL2_HUMAN, Q9Y4K0
    Domain: The fourth SRCR domain plays a important role in optimizing the catalytic activity of the lysyl-oxidase
    like (LOX) catalytic domain
    Similarity: Belongs to the lysyl oxidase family
    Similarity: Contains 4 SRCR domains


    LOXL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LOXL2_HUMAN, Q9Y4K0
    Function: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to
    the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of
    extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to
    fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV
    scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of
    trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved
    in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of
    E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following
    hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting
    that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by
    regulating expression of factors that control chondrocyte differentiation
    Catalytic activity: Peptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2)
    Enzyme regulation: According to some reports, it is inhibited by beta-aminopropionitrile (BAPN) (PubMed:20439985
    and PubMed:23319596). According to another report, it is not inhibited by beta-aminopropionitrile (BAPN)
    (PubMed:20306300). Specifically inhibited by a mouse monoclonal antibody AB0023, inhibition occurs in a
    non-competitive manner
    Biophysicochemical properties: Kinetic parameters: KM=1.01 mM for 1,5-diaminopentane; KM=1.05 mM for spermine;
    KM=0.59 uM for tropoelastin (without the first three SRCR domains); KM=0.62 uM for tropoelastin (without all four
    SRCR domains); Note=kcat is 2.04 min(-1) with tropoelastin as substrate (without the first three SRCR domains).
    kcat is 0.62 min(-1) with tropoelastin as substrate (without all four SRCR domains);
    Induction: Strongly induced in hypoxia. Direct transcriptional target of HIF1A

         Genatlas biochemistry entry for LOXL2:
    lysyl oxidase-like 2,extracellular matrix enzyme,widely expressed predominantly in reproductive tissues
    (placenta,uterus,prostate)

         Enzyme Numbers (IUBMB): EC 1.4.3.131 EC 1.4.32

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA--
    GO:0003714transcription corepressor activity IDA--
    GO:0004720protein-lysine 6-oxidase activity IDA--
    GO:0005044scavenger receptor activity IEA--
    GO:0005507copper ion binding IEA--
         
    LOXL2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for LOXL2:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Loxl2 (no phenotypes)

    LOXL2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LOXL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LOXL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LOXL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LOXL2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target LOXL2:
    hsa-mir-192 (MIRT004135)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LOXL2
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate LOXL2 (see all 10):
    hsa-miR-425 hsa-miR-29a hsa-miR-29c hsa-miR-1297 hsa-miR-466 hsa-miR-26a hsa-miR-642b hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmidLOXL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LOXL2
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: LOXL2 (NM_002318)
    Sino Biological Human cDNA Clone for LOXL2
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                         Customized lentivirus expression plasmids for stable overexpression of LOXL2 

    Cell Line
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    Search LifeMap BioReagents cell lines for LOXL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOXL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LOXL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen formation0.74
    Extracellular matrix organization0.39
    Assembly of collagen fibrils and other multimeric structures0.65
    2Elastic fibre formation
    Elastic fibre formation0.84
    3Crosslinking of collagen fibrils
    Crosslinking of collagen fibrils

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5        Reactome Pathways for LOXL2
        Extracellular matrix organization
    Assembly of collagen fibrils and other multimeric structures
    Crosslinking of collagen fibrils
    Elastic fibre formation
    Collagen formation



    LOXL2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LOXL2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for LOXL2 (Q9Y4K02, 3 ENSP000003737834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFL7Q9UHF12, 3, ENSP000003078434MINT-6743620 I2D: score=1 STRING: ENSP00000307843
    PDIA3P301012, 3MINT-4301285 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia ISS--
    GO:0001837epithelial to mesenchymal transition IDA16096638
    GO:0001935endothelial cell proliferation IMP--
    GO:0002040sprouting angiogenesis IMP--
    GO:0006351transcription, DNA-dependent IEA--

    LOXL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LOXL2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LOXL2

    2 HMDB Compounds for LOXL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    Docosanoyl-CoAbehenoyl-CoA (see all 2)----

    5 Novoseek inferred chemical compound relationships for LOXL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-aminopropionitrile 80 2 16023247 (1)
    amine 55.1 5 19724858 (1), 17394133 (1), 18949373 (1), 10212285 (1)
    lysine 34.7 1 16023247 (1)
    copper 33.7 2 12686136 (1), 16023247 (1)
    quinone 32.6 1 12686136 (1)

    Search CenterWatch for drugs/clinical trials and news about LOXL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LOXL2 gene: 
    NM_002318.2  

    Unigene Cluster for LOXL2:

    Lysyl oxidase-like 2
    Hs.626637  [show with all ESTs]
    Unigene Representative Sequence: NM_002318
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389131(uc010lty.1 uc003xdh.1) ENST00000520617 ENST00000523833
    ENST00000520349 ENST00000518878 ENST00000522446 ENST00000519809 ENST00000520925
    ENST00000518472 ENST00000524144 ENST00000520871 ENST00000518083 ENST00000524168
    ENST00000519243 ENST00000524075
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LOXL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LOXL2

    Additional mRNA sequence: 

    AF117949.1 AK098436.1 AK124508.1 AK222477.1 AK293292.1 AK312266.1 BC000594.2 BC020481.1 
    U89942.1 

    22 DOTS entries:

    DT.95310597  DT.455906  DT.100860641  DT.100860643  DT.121471990  DT.101981869  DT.97797797  DT.95310623 
    DT.95310598  DT.75173603  DT.102839062  DT.100044391  DT.100833490  DT.121471952  DT.121472016  DT.95347853 
    DT.121471948  DT.121471991  DT.121472002  DT.100736600  DT.100860655  DT.121472033 

    24/454 AceView cDNA sequences (see all 454):

    BF941895 BQ888079 AI419432 BU849963 BU502721 AI246352 BX365591 BX352733 
    AL701581 BU849698 BQ962783 BP346677 BX355054 CA866628 BI768284 AW302580 
    BX388123 BQ945043 BQ719743 BX401087 AW151120 BU859442 BM760148 BX331894 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LOXL2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
    SP1:              -     -                                               -                                         -           -                           
    SP2:                                                                                                              -           -                 -         
    SP3:                                                                                                                                                      
    SP4:                    -                                                                                                                                 
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for LOXL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LOXL2 expression in normal human tissues (normalized intensities)      LOXL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCATCACA
    LOXL2 Expression
    About this image


    LOXL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Node Cells Atrioventricular Node
             Cardiac Myocytes   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             reticulocytes   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   
     
     Chorion (Extraembryonic Tissues)
             chorion villus cells   
     
     Cartilage (Muscoskeletal System)
             fetal cartilage   

    See LOXL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LOXL2

    SOURCE GeneReport for Unigene cluster: Hs.626637

    UniProtKB/Swiss-Prot: LOXL2_HUMAN, Q9Y4K0
    Tissue specificity: Expressed in many tissues. Highest expression in reproductive tissues, placenta, uterus and
    prostate. Up-regulated in a number of cancers cells and tissues

        SABiosciences Custom PCR Arrays for LOXL2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LOXL2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Loxl21 , 5 lysyl oxidase-like 21, 5 84.65(n)1
    86.55(a)1
      14 (36.06 cM)5
    943521  NM_033325.21  NP_201582.21 
     696094765 
    chicken
    (Gallus gallus)
    Aves LOXL21 lysyl oxidase-like 2 77.19(n)
    81.05(a)
      419533  XM_003642546.1  XP_003642594.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119182 Transcribed sequence with moderate similarity to protein more 78.98(n)    CF225328.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.7152 Transcribed sequences 97.22(n)    57034883 
    fruit fly
    (Drosophila melanogaster)
    Insecta lox21 , 3 protein-lysine 6-oxidase3
    lysyl oxidase-like 21
    42(a)
    (best of 2)3
    54.22(n)1
    46.17(a)1
      58A13
    374851  NM_079082.31  NP_523806.21 


    ENSEMBL Gene Tree for LOXL2 (if available)
    TreeFam Gene Tree for LOXL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LOXL2 gene
    CD62  CD163L12  LOXL42  CD1632  LOXL32  SSC5D2  PRSS122  CD5L2  
    LOX2  SRCRB4D2  LOXL12  DMBT12  
    9 SIMAP similar genes for LOXL2 using alignment to 9 protein entries:     LOXL2_HUMAN (see all proteins):
    LOXL4    LGALS3BP    HHIPL1    SSC5D    LOXL3    CD163
    CD163L1    CD6    DMBT1

    LOXL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2178 SNPs in LOXL2 are shown (see all 2178)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792407121,2
    C--23154354(+) GTGGC-/TGTTGTTT 1 -- ds50011Minor allele frequency- TGT:0.00CSA 2
    rs1885789991,2
    --23154375(+) ACTTCC/TCATCC 1 -- ds50010--------
    rs1404897341,2
    --23154388(+) CCCTCA/GCACAA 1 -- ds50010--------
    rs1914630611,2
    --23154426(+) AAAAAC/TCACAG 1 -- ut310--------
    rs78464331,2
    C,F,H--23154444(+) AGAAAG/TATTAT 1 -- ut316Minor allele frequency- T:0.03NS EA WA NA 658
    rs78346411,2
    C,F,A,H--23154486(+) TTAGAC/TTGCTT 1 -- ut31105Minor allele frequency- N:0.00EA NS NA PA EU CA WA CSA 6452
    rs795749901,2
    C,F--23154575(+) CTGAGG/AACCCA 1 -- ut311Minor allele frequency- A:0.04WA 118
    rs78133491,2
    C,F,A,H--23154600(+) AACCAT/CGAATG 1 -- ut3125Minor allele frequency- C:0.39NS EA NA CSA WA 2341
    rs1821453451,2
    --23154601(+) ACCACC/GAATGT 1 -- ut310--------
    rs1872470761,2
    --23154626(+) TTCTGG/TCCACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LOXL2 (23154410 - 23282841 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for LOXL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6118CNV Insertion18451855
    nsv890680CNV Loss21882294
    esv25599CNV Loss19812545
    nsv890681CNV Loss21882294
    nsv470206CNV Gain18288195
    nsv831268CNV Gain17160897


    Human Gene Mutation Database (HGMD): LOXL2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606663    OMIM disorders: --

    18 diseases for LOXL2:    About MalaCards
    wilson disease    malignant peripheral nerve sheath tumor    intracranial aneurysm    scoliosis
    esophageal squamous cell carcinoma    glaucoma    lung adenocarcinoma    squamous cell carcinoma
    esophagitis    hypoxia    gastric cancer    breast cancer
    pancreatitis    colorectal cancer    endotheliitis    adenocarcinoma
    prostatitis    prostate cancer


    LOXL2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for LOXL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 28.7 6 18559498 (4), 12820424 (1), 17394133 (1)
    tumors 27.8 25 19625348 (4), 19330836 (3), 17394133 (2), 16096638 (2) (see all 9)
    breast cancer 13.2 13 19330836 (3), 17394133 (1), 12154058 (1)
    metastasis 9.01 1 19625348 (7), 20012301 (1)
    cancer 2.15 5 19015874 (1), 19625348 (1), 17394133 (1)

    Genetic Association Database (GAD): LOXL2
    Human Genome Epidemiology (HuGE) Navigator: LOXL2 (3 documents)

    Export disorders for LOXL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LOXL2 gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with LOXL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms. (PubMed id 17287949)1, 4, 9 Akagawa H....Inoue I. (2007)
    2. The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues. (PubMed id 10212285)1, 2, 9 Jourdan-Le Saux C.... Csiszar K. (1999)
    3. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. (PubMed id 16096638)1, 2, 9 Peinado H....Portillo F. (2005)
    4. The lysyl oxidases LOX and LOXL2 are necessary and su fficient to repress E-cadherin in hypoxia: insights into cellular transformatio n processes mediated by HIF-1. (PubMed id 20026874)1, 2, 9 Schietke R....Wiesener M.S. (2010)
    5. The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3. (PubMed id 9722957)1, 3, 9 Jourdan-Le Saux C....Csiszar K. (1998)
    6. Post-translational Modifications of Recombinant Human Lysyl Oxidase- like 2 (rhLOXL2) Secreted from Drosophila S2 Cells. (PubMed id 23319596)1, 2 Xu L....Mure M. (2013)
    7. Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. (PubMed id 22483618)1, 2 Herranz N.... Peiro S. (2012)
    8. LOXL2-mediated matrix remodeling in metastasis and ma mmary gland involution. (PubMed id 21233336)1, 2 Barker H.E....Erler J.T. (2011)
    9. Lysyl oxidase-like protein-2 regulates sprouting angi ogenesis and type IV collagen assembly in the endothelial basement membrane. (PubMed id 21835952)1, 2 Bignon M....Germain S. (2011)
    10. The human lysyl oxidase-like 2 protein functions as a n amine oxidase toward collagen and elastin. (PubMed id 20306300)1, 2 Kim Y.M....Kim Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4017 HGNC: 6666 AceView: LOXL2andENTPD4 Ensembl:ENSG00000134013 euGenes: HUgn4017
    ECgene: LOXL2 H-InvDB: LOXL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LOXL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LOXL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LOXL2 gene:
    Search GeneIP for patents involving LOXL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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