External Ids for LOX Gene
Previous GeneCards Identifiers for LOX Gene
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. [provided by RefSeq, Nov 2015]
GeneCards Summary for LOX Gene
LOX (Lysyl Oxidase) is a Protein Coding gene. Diseases associated with LOX include Oral Submucous Fibrosis and Occipital Horn Syndrome. Among its related pathways are Collagen biosynthesis and modifying enzymes and Degradation of the extracellular matrix. GO annotations related to this gene include copper ion binding and protein-lysine 6-oxidase activity. An important paralog of this gene is LOXL1.
UniProtKB/Swiss-Prot for LOX Gene
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.