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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LOX Gene

protein-coding GIFtS: 63
GCID: GC05M121429

lysyl oxidase

Explore 94 diseases affiliated with
LOX via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lysyl Oxidase¹ ² ³
EC 1.4.3.13³ ⁸
Protein-Lysine 6-Oxidase²

External Ids:	HGNC: 6664¹	Entrez Gene: 4015²	Ensembl: ENSG00000113083⁷	OMIM: 153455⁵	UniProtKB: P28300³

Export aliases for LOX gene to outside databases

Previous GC identifers: GC05M121103 GC05M121800 GC05M121432 GC05M121478 GC05M116590

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LOX:

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and

elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine

residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the

encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis

laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. (provided

by RefSeq, May 2010)

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300

Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to

fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in

tumor suppression

Gene Wiki entry for LOX (Lysyl oxidase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LOX gene promoter:
NF-1 STAT1 AP-1 ATF-2 Nkx2-5 IRF-1 deltaCREB STAT3 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LOX promoter sequence

Search SABiosciences Chromatin IP Primers for LOX

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LOX

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2 Ensembl cytogenetic band: 5q23.2 HGNC cytogenetic band: 5q23.3-q31.2

LOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOX gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M121429: view genomic region (about GC identifiers)

Start:	121,398,890 bp from pter	End:	121,414,055 bp from pter
Size:	15,166 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300 (See protein sequence)

Recommended Name: Protein-lysine 6-oxidase precursor

Size: 417 amino acids; 46944 Da

Cofactor: Copper

Cofactor: Contains 1 lysine tyrosylquinone (By similarity)

Subcellular location: Secreted, extracellular space

Miscellaneous: The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via

interaction with tropoelastin (By similarity)

Secondary accessions: B2R5Q3 Q5FWF0

Explore the universe of human proteins at neXtProt for LOX: NX_P28300

Post-translational modifications:

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a

topaquinone produced by oxidation of tyrosine¹

Proteolytically activated by BMP1 (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P28300

4/9 DME Specific Peptides for LOX (P28300) (see all 9)

QASTYVQ

AAPGAWRQ

PGNYILKV

IQWENNGQV

LOX Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001171573.1 NP_002308.2

ENSEMBL proteins:

ENSP00000231004 ENSP00000427538

Reactome Protein details: P28300
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Proteins (see all 2): LOX OriGene Protein Over-expression Lysate: LOX OriGene Custom Protein Services for LOX
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	Novus Biologicals LOX Protein Novus Biologicals LOX Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LOX

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	--	--
GO:0005581	collagen	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005634	nucleus	IEA	--

LOX for ontologies About GeneDecksing

LOX Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LOX
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	OriGene Antibodies (see all 18): LOX OriGene Custom Antibody Services for LOX
	GenScript Superior Antibodies for LOX
	Novus Biologicals LOX Antibodies
	Abcam antibodies for LOX
	Uscn Antibodies for LOX
	ThermoFisher Antibody for LOX

Assay Products for LOX:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LOX
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LOX

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LOX for domains About GeneDecksing

2 InterPro domains/families:

IPR001695 Lysyl_oxidase

IPR019828 Lysyl_oxidase_CS

Graphical View of Domain Structure for InterPro Entry P28300

ProtoNet protein and cluster: P28300

1 Blocks protein family: IPB001695 Lysyl oxidase

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300

Similarity: Belongs to the lysyl oxidase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300

Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to

fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in

tumor suppression

Catalytic activity: Peptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2)

Genatlas biochemistry entry for LOX:

lysyl oxidase,copper dependent,processed by BMP1 to the mature enzyme necessary for the formation of covalent

cross-links in collagen and elastic fibers

Enzyme Number (IUBMB): EC 1.4.3.13¹ ²

miRNA Products:		OriGene 3'-UTR Clone: LOX Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LOX
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate LOX (see all 55):
		hsa-miR-411* hsa-miR-21* hsa-miR-379* hsa-miR-429 hsa-miR-4272 hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: LOX 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LOX (see all 7) OriGene shRNA RFP: LOX OriGene siRNA: LOX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LOX

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LOX

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: LOX (NM_000697)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOX

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LOX
		Search LifeMap BioReagents cell lines for LOX

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOX

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004720	protein-lysine 6-oxidase activity	IEA	--
GO:0005507	copper ion binding	IEA	--
GO:0005515	protein binding	IPI	19570982

LOX for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for LOX:

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-outs for LOX: Lox^tm1Soin Lox^tm1Ikh
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Lox):

behavior/neurological	cardiovascular system	homeostasis/metabolism	integument	mortality/aging
muscle	respiratory system

LOX for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Collagen formation

	Collagen formation	1.00			Extracellular matrix organization	0.54
	Assembly of collagen fibrils and other multimeric structures	0.65

Elastic fibre formation

Elastic fibre formation

1.00

Crosslinking of collagen fibrils

Crosslinking of collagen fibrils

1.00

Tropoelastin associates with microfibrils

Elastin cross-linking by lysyl oxidase

0.55

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for LOX (see all 6)

	Extracellular matrix organization
	Assembly of collagen fibrils and other multimeric structures
	Crosslinking of collagen fibrils
	Elastic fibre formation
	Collagen formation

LOX for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LOX

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/13 Interacting proteins for LOX (P28300^{1, 3} ENSP00000231004⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELN	P15502¹^,³, ENSP00000252034⁴	EBI-3893481,EBI-1222108 I2D: score=2 STRING: ENSP00000252034
DHDDS	Q86SQ9³, ENSP00000353104⁴	I2D: score=2 STRING: ENSP00000353104
DPT	Q07507³, ENSP00000356791⁴	I2D: score=2 STRING: ENSP00000356791
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
HIST1H1B	P16401³, ENSP00000330074⁴	I2D: score=1 STRING: ENSP00000330074

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001568	blood vessel development	IEA	--
GO:0006464	cellular protein modification process	TAS	1685472
GO:0009725	response to hormone stimulus	--	--
GO:0030199	collagen fibril organization	IEA	--
GO:0030324	lung development	IEA	--

LOX for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LOX for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LOX

5 HMDB Compounds for LOX About this table

Compound	Synonyms	CAS #	PubMed Ids
Ammonia	NH3 (see all 31)	7664-41-7	--
Copper	Cu (see all 2)	7440-50-8	--
Hydrogen peroxide	Hydrogen peroxide (see all 44)	7722-84-1	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/104 Novoseek chemical compound relationships for LOX gene (see all 104) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
beta-aminopropionitrile	92.5	41	19661442 (2), 1358170 (2), 19440335 (2), 14550642 (1) (see all 23)
ndga	78.8	43	15801029 (2), 10600514 (2), 12929751 (1), 16406549 (1) (see all 26)
arachidonic acid	78.7	114	8485318 (4), 15801029 (3), 9369949 (3), 9467967 (3) (see all 71)
desmosine	77.2	6	18158636 (1), 18847364 (1), 12163653 (1)
hydroxylysine	75.8	13	7902322 (1), 15652501 (1), 19247601 (1), 1685472 (1) (see all 8)
alpha-aminoadipic semialdehyde	75.3	5	1680355 (1), 16909208 (1), 1357535 (1), 7899140 (1)
rev 5901	75.2	4	10600514 (2), 16406549 (1), 18927292 (1)
aa861	74	7	16903934 (2), 16406549 (1), 15931672 (1), 18765235 (1) (see all 6)
baicalein	71.8	9	10600514 (2), 17164225 (1), 15931672 (1), 12481414 (1) (see all 7)
topaquinone	70	2	14967060 (1)

Search CenterWatch for drugs/clinical trials and news about LOX / LYOX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LOX gene (2 alternative transcripts):

NM_001178102.1 NM_002317.5

Unigene Cluster for LOX:

Lysyl oxidase

Hs.102267 [show with all ESTs]

Unigene Representative Sequence: NM_002317

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000231004(uc010jcp.3 uc010jcq.3 uc010jcr.3 uc011cwk.2 uc003ksu.3)

ENST00000513319 ENST00000505593 ENST00000503759 ENST00000508067

miRNA Products:		OriGene 3'-UTR Clone: LOX Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LOX
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate LOX (see all 55):
		hsa-miR-411* hsa-miR-21* hsa-miR-379* hsa-miR-429 hsa-miR-4272 hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: LOX 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LOX (see all 7) OriGene shRNA RFP: LOX OriGene siRNA: LOX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LOX

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LOX (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LOX (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LOX (NM_000697)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LOX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LOX

Additional cDNA sequence:

AF039291.1 AK307559.1 AK307732.1 AK311354.1 AK312269.1 AK315873.1 AK316309.1 BC074820.2

BC074872.2 BC089436.1 M94054.1 S45875.1 S78694.1

15 DOTS entries:

DT.454042 DT.102829366 DT.100019519 DT.92428708 DT.120804946 DT.95273505 DT.120804894 DT.120804911

DT.120804882 DT.120804902 DT.120804908 DT.120804943 DT.121636432 DT.92428700 DT.99970925

24/354 AceView cDNA sequences (see all 354):

CA417659 CB853038 AI755200 BF732817 AU102655 CA445395 H84472 BU620545

W70343 AW206041 AW137928 CA389459 BU615699 AW003727 H98150 NM_002317

AI038338 CR591353 AI080357 AI831839 BX436921 CA441767 BM676929 BP336740

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LOX (see all 6) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	^	10
SP1:					-		-				-						-
SP2:					-		-		-		-
SP3:									-		-						-
SP4:											-						-
SP5:																	-

ECgene alternative splicing isoforms for LOX

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LOX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTATTTC

About this image

LOX expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Cumulus Cells

Ovary

Heart

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Adult human kidney epithelial cells (Primary Cell)

Kidney

Definitive endoderm-like cells (A scalable, suspensi...)

Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)

Cartilage

See LOX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LOX

SOURCE GeneReport for Unigene cluster: Hs.102267

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300

Tissue specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas

SABiosciences Expression via Pathway-Focused PCR Arrays including LOX:

Fibrosis in human mouse rat

Polycomb & Trithorax Target Genes in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LOX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LOX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LOX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LOX

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOX

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LOX gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lox^{1 , 5}	lysyl oxidase^{1, 5}	84.43(n)¹ 87.59(a)¹		18 (28.22 cM)⁵ 16948¹ NM_010728.2¹ NP_034858.2¹ 52517238⁵
chicken (Gallus gallus)	Aves	LOX¹	lysyl oxidase	73.8(n) 77.83(a)		396474 NM_205481.1 NP_990812.1
lizard (Anolis carolinensis)	Reptilia	LOX⁶	--	69(a)	1 ↔ 1	GL343193.1(11733638-11748190)
zebrafish (Danio rerio)	Actinopterygii	Dr.11427²	Transcribed sequence with moderate similarity to protein more	73.52(n)		BG302899.1
fruit fly (Drosophila melanogaster)	Insecta	lox⁶	lysyl oxidase-like	23(a)	possible ortholog	3R(27284102-27285591)

ENSEMBL Gene Tree for LOX (if available)
TreeFam Gene Tree for LOX (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LOX gene

LOXL2² CD6² CD163L1² LOXL4² LOXL3² CD163² SSC5D² PRSS12²

CD5L² SRCRB4D² LOC619207² LOXL1²

2 SIMAP similar genes for LOX using alignment to 4 protein entries: LYOX_HUMAN (see all proteins):

LOXL1 LOXL3

LOX for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112770585^1,2		--	116590147(+)	`TGTGTG/ATATGT`	2	--	ds500¹		2	CSA WA	120
rs73795215^1,2	C,	--	116591200(+)	`AATAAG/AGTTAT`	2	--	ut3¹		1	WA	2
rs10519693^1,2	C,F,H,	--	116591249(+)	`TGTATT/ACTCAT`	2	--	ut3¹		91	NS EA PA EU CA WA NA CSA	4838
rs74536753^1,2		--	116591555(+)	`CGGCAG/CTTATT`	2	--	ut3¹		1	WA	118
rs79432032^1,2	F,	--	116591848(+)	`TTTTAA/GAAATA`	2	--	ut3¹		1	EA	120
rs79582421^1,2	F,	--	116592121(+)	`TGATGA/TTATTG`	2	--	ut3¹		1	WA	118
rs78701393^1,2	F,	--	116592130(+)	`TGCCTA/GGTTTT`	2	--	ut3¹		1	WA	118
rs2913398^1,2	C	--	116592421(-)	`ATCCTT/GAGCCA`	2	--	ut3¹		1	NA	2
rs17148765^1,2	C,F,	--	116592640(+)	`TTAATA/GTAGGA`	2	--	ut3¹		8	NA CSA WA EA	504
rs41367345^1,2	C,	--	116593211(-)	`TGGGAC/TTGGTA`	2	--	ut3¹		2	NA	122

HapMap Linkage Disequilibrium report for LOX (121398890 - 121414055 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LOX: --
Human Gene Mutation Database (HGMD): LOX

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LOX

DNA2.0 Custom Variant and Variant Library Synthesis for LOX

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LOX for disorders           About GeneDecksing

OMIM gene information: 153455    OMIM disorders: --

20/94 diseases for LOX (see all 94):    About MalaCards

cutis laxa occipital horn syndrome ehlers-danlos syndrome oral submucous fibrosis

congenital ichthyosiform erythroderma connective tissue disease amyotrophic lateral sclerosis gingival overgrowth

intracranial aneurysm osteogenesis imperfecta anaplastic large cell lymphoma duchenne muscular dystrophy

clear cell renal cell carcinoma proliferative diabetic retinopathy marfan syndrome lateral sclerosis

menkes disease bronchiolitis obliterans muscular dystrophy wilson disease

1 disease from the University of Copenhagen DISEASES database for LOX:

Melanoma

10/70 Novoseek disease relationships for LOX gene (see all 70) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
occipital horn syndrome	72.6	1	8638917 (1)
menkes disease	70.3	3	1975662 (1), 8980283 (1), 12838205 (1)
oral submucous fibrosis	60.6	6	8537914 (3), 10426196 (1), 18764858 (1)
cutis laxa	55.5	2	9111998 (2)
oxidase deficiency	48.7	2	9111998 (1), 15831618 (1)
tumors	39.4	125	1737396 (5), 8137286 (3), 17685448 (3), 15374948 (3) (see all 62)
cancer	37	47	17471532 (3), 11201293 (2), 17943411 (2), 8564968 (1) (see all 33)
collagen fibril	36.5	4	8989253 (1), 16341622 (1), 17071617 (1), 7915281 (1)
metastasis	31.9	53	19816945 (3), 16642001 (3), 19526206 (3), 17079439 (3) (see all 23)
colon adenocarcinoma	28.9	1	16545574 (1)

Genetic Association Database (GAD): LOX
Human Genome Epidemiology (HuGE) Navigator: LOX (13 documents)

Export disorders for LOX gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LOX gene, integrated from 9 sources (see all 554):
(articles sorted by number of sources associating them with LOX)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2. (PubMed id 1685472)^{1, 2, 3, 9} Haemaelaeinen E.-R.... Kivirikko K.I. (1991)
Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene. (PubMed id 10391127)^{1, 2, 9} Contente S.... Friedman R.M. (1999)
The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene). (PubMed id 1357535)^{1, 2, 9} Mariani T.J.... Deak S.B. (1992)
Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. (PubMed id 12750963)^{1, 4, 9} Yoneyama T....Inoue I. (2003)
Mutations in the lysyl oxidase gene are not associated with amyotrophic lateral sclerosis. (PubMed id 11675877)^{1, 4, 9} Chioza B.A....Radunovic A. (2001)
Structure of the human lysyl oxidase gene. (PubMed id 7902322)^{1, 2, 9} Haemaelaeinen E.-R.... Kivirikko K.I. (1993)
Characterization of the human lysyl oxidase gene locus. (PubMed id 1352776)^{1, 2, 9} Svinarich D.M....Krawetz S.A. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. (PubMed id 12101112)^{1, 4} Chiu C.J....Chen C.J. (2002)
A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase. (PubMed id 7706256)^{1, 2} Kim Y.... Csiszar K. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4015	HGNC: 6664	AceView: LOX	Ensembl:ENSG00000113083	euGenes: HUgn4015
ECgene: LOX	H-InvDB: LOX

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LOX	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LOX	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LOX gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LOX gene:
Search GeneIP for patents involving LOX

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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WILSON DISEASE
LUNG TUMOR
Cutis Laxa
Oral Submucous Fibrosis
COLON CARCINOMA
OXIDASE DEFICIENCY
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LOX Gene

lysyl oxidase

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