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LOX Gene

protein-coding   GIFtS: 66
GCID: GC05M121429

Lysyl Oxidase

  See LOX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lysyl Oxidase1 2 3
EC 1.4.3.133 8
Protein-Lysine 6-Oxidase2

External Ids:    HGNC: 66641   Entrez Gene: 40152   Ensembl: ENSG000001130837   OMIM: 1534555   UniProtKB: P283003   

Export aliases for LOX gene to outside databases

Previous GC identifers: GC05M121103 GC05M121800 GC05M121432 GC05M121478 GC05M116590


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LOX Gene:
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens
and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and
hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular
matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of
autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, May 2010)

GeneCards Summary for LOX Gene:
LOX (lysyl oxidase) is a protein-coding gene. Diseases associated with LOX include oral submucous fibrosis, and occipital horn syndrome. GO annotations related to this gene include protein-lysine 6-oxidase activity and copper ion binding. An important paralog of this gene is LOXL2.

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300
Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors
to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct
role in tumor suppression

Gene Wiki entry for LOX (Lysyl oxidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the LOX gene promoter:
         NF-1   STAT1   AP-1   ATF-2   Nkx2-5   IRF-1   deltaCREB   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLOX promoter sequence
   Search Chromatin IP Primers for LOX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.3-q31.2

LOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOX gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M121429:  view genomic region     (about GC identifiers)

Start:
121,398,890 bp from pter      End:
121,414,055 bp from pter
Size:
15,166 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300 (See protein sequence)
Recommended Name: Protein-lysine 6-oxidase precursor  
Size: 417 amino acids; 46944 Da
Cofactor: Copper
Cofactor: Contains 1 lysine tyrosylquinone (By similarity)
Miscellaneous: The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via
interaction with tropoelastin (By similarity)
Secondary accessions: B2R5Q3 Q5FWF0

Explore the universe of human proteins at neXtProt for LOX: NX_P28300

Explore proteomics data for LOX at MOPED

Post-translational modifications: 

  • The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine
    with a topaquinone produced by oxidation of tyrosine1
  • Proteolytically activated by BMP1 (By similarity)1
  • Glycosylation2 at Asn81, Thr89, Asn97, Thr113, Thr120, Ser130, Thr131, Ser132, Asn144, Thr413
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LOX (P28300) (see all 9)
     QASTYVQ  AAPGAWRQ  PGNYILKV  IQWENNGQV 


    See LOX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171573.1  NP_002308.2  

    ENSEMBL proteins: 
     ENSP00000231004   ENSP00000427538  
    Reactome Protein details: P28300

    LOX Human Recombinant Protein Products:

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    Novus Biologicals LOX Proteins
    Novus Biologicals LOX Lysate
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    Cloud-Clone Corp. Proteins for LOX

     
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    LOX Assay Products:

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    Search eBioscience for ELISAs for LOX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001695 Lysyl_oxidase
     IPR019828 Lysyl_oxidase_CS

    Graphical View of Domain Structure for InterPro Entry P28300

    ProtoNet protein and cluster: P28300

    1 Blocks protein domain: IPB001695 Lysyl oxidase

    UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300
    Similarity: Belongs to the lysyl oxidase family


    Find genes that share domains with LOX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYOX_HUMAN, P28300
    Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors
    to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct
    role in tumor suppression
    Catalytic activity: Peptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2)

         Genatlas biochemistry entry for LOX:
    lysyl oxidase,copper dependent,processed by BMP1 to the mature enzyme necessary for the formation of covalent
    cross-links in collagen and elastic fibers

         Enzyme Number (IUBMB): EC 1.4.3.131 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004720protein-lysine 6-oxidase activity IEA--
    GO:0005507copper ion binding IEA--
    GO:0005515protein binding IPI19570982
    GO:0016641oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor ----
         
    Find genes that share ontologies with LOX           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LOX:
     Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lox):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  integument  mortality/aging 
     muscle  respiratory system 

    Find genes that share phenotypes with LOX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LOX: Loxtm1Soin Loxtm1Ikh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LOX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LOX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LOX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LOX

    miRNA
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    miRTarBase miRNAs that target LOX:
    hsa-mir-335-5p (MIRT018405)

    Block miRNA regulation of human, mouse, rat LOX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LOX (see all 55):
    hsa-miR-411* hsa-miR-21* hsa-miR-379* hsa-miR-429 hsa-miR-4272 hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidLOX 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LOX

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOX

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LYOX_HUMAN, P28300: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    chloroplast2
    cytosol2
    mitochondrion2
    nucleus2
    plasma membrane2
    cytoskeleton1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005581collagen IEA--
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with LOX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LOX About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen formation0.75
    Crosslinking of collagen fibrils0.00
    Assembly of collagen fibrils and other multimeric structures0.62
    2Elastic fibre formation
    Elastic fibre formation0.73
    3Degradation of the extracellular matrix
    Extracellular matrix organization0.34


    Find genes that share SuperPaths with LOX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for LOX
        Crosslinking of collagen fibrils
    Elastic fibre formation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including LOX: 
              Fibrosis in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LOX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for LOX (P283001, 3 ENSP000002310044) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELNP155021, 3, ENSP000002520344EBI-3893481,EBI-1222108 I2D: score=2 STRING: ENSP00000252034
    BTKQ061873, ENSP000003081764I2D: score=2 STRING: ENSP00000308176
    DHDDSQ86SQ93, ENSP000003531044I2D: score=2 STRING: ENSP00000353104
    DPTQ075073, ENSP000003567914I2D: score=2 STRING: ENSP00000356791
    EGFL7Q9UHF13, ENSP000003078434I2D: score=1 STRING: ENSP00000307843
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development IEA--
    GO:0006464cellular protein modification process TAS1685472
    GO:0009725response to hormone ----
    GO:0030198extracellular matrix organization TAS--
    GO:0030199collagen fibril organization IEA--

    Find genes that share ontologies with LOX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LOX (LYOX)

    5 HMDB Compounds for LOX    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CopperCu (see all 2)7440-50-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for LOX gene (see all 104)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-aminopropionitrile 92.5 41 19661442 (2), 1358170 (2), 19440335 (2), 14550642 (1) (see all 23)
    ndga 78.8 43 15801029 (2), 10600514 (2), 12929751 (1), 16406549 (1) (see all 26)
    arachidonic acid 78.7 114 8485318 (4), 15801029 (3), 9369949 (3), 9467967 (3) (see all 71)
    desmosine 77.2 6 18158636 (1), 18847364 (1), 12163653 (1)
    hydroxylysine 75.8 13 7902322 (1), 15652501 (1), 19247601 (1), 1685472 (1) (see all 8)
    alpha-aminoadipic semialdehyde 75.3 5 1680355 (1), 16909208 (1), 1357535 (1), 7899140 (1)
    rev 5901 75.2 4 10600514 (2), 16406549 (1), 18927292 (1)
    aa861 74 7 16903934 (2), 16406549 (1), 15931672 (1), 18765235 (1) (see all 6)
    baicalein 71.8 9 10600514 (2), 17164225 (1), 15931672 (1), 12481414 (1) (see all 7)
    topaquinone 70 2 14967060 (1)



    Find genes that share compounds with LOX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LOX gene (2 alternative transcripts): 
    NM_001178102.1  NM_002317.5  

    Unigene Cluster for LOX:

    Lysyl oxidase
    Hs.102267  [show with all ESTs]
    Unigene Representative Sequence: NM_002317
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231004(uc010jcp.3 uc010jcq.3 uc010jcr.3 uc011cwk.2 uc003ksu.3)
    ENST00000513319 ENST00000505593 ENST00000503759 ENST00000508067
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate LOX (see all 55):
    hsa-miR-411* hsa-miR-21* hsa-miR-379* hsa-miR-429 hsa-miR-4272 hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidLOX 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat LOX
      QuantiFast Probe-based Assays in human, mouse, rat LOX

    Additional mRNA sequence: 

    AF039291.1 AK307559.1 AK307732.1 AK311354.1 AK312269.1 AK315873.1 AK316309.1 BC074820.2 
    BC074872.2 BC089436.1 M94054.1 S45875.1 S78694.1 

    15 DOTS entries:

    DT.454042  DT.102829366  DT.100019519  DT.92428708  DT.120804946  DT.95273505  DT.120804894  DT.120804911 
    DT.120804882  DT.120804902  DT.120804908  DT.120804943  DT.121636432  DT.92428700  DT.99970925 

    Selected AceView cDNA sequences (see all 354):

    AI521206 AI217454 BU630325 AU280695 AI753751 CA412280 CA414453 BU627521 
    AI240191 AI343556 BF589427 AI755066 AI091488 CA445706 BE876274 BM676929 
    CF264898 AI824188 BX097300 CA412131 AL711116 AI755200 BM720822 CA441767 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LOX (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10
    SP1:              -     -           -                 -                                                   
    SP2:              -     -     -     -                                                                     
    SP3:                          -     -                 -                                                   
    SP4:                                -                 -                                                   
    SP5:                                                  -                                                   


    ECgene alternative splicing isoforms for LOX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    LOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTATTTC
    LOX Expression
    About this image


    LOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     NULL (Uncategorized)    fully expand to see all 4 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Peripheral Nervous System (Nervous System)
             Immature Schwann Cells Peripheral Nerve Domain
     
     Kidney (Urinary System)
             Metanephros
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    LOX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LOX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.102267

    UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300
    Tissue specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LOX: 
              Fibrosis in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat LOX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LOX gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lox1 , 5 lysyl oxidase1, 5 84.43(n)1
    87.59(a)1
      18 (28.22 cM)5
    169481  NM_001286182.11  NP_001273111.11 
     525172385 
    chicken
    (Gallus gallus)
    Aves LOX1 lysyl oxidase 74.85(n)
    78.01(a)
      396474  NM_205481.1  NP_990812.1 
    lizard
    (Anolis carolinensis)
    Reptilia LOX6
    lysyl oxidase
    72(a)
    1 ↔ 1
    GL343193.1(11729840-11748537)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lox1 lysyl oxidase 70.16(n)
    73.3(a)
      780067  NM_001079143.1  NP_001072611.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.114272 Transcribed sequence with moderate similarity to protein more 73.52(n)    BG302899.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lox6
    lox26
    lysyl oxidase-like 2
    28(a)
    23(a)
    many ↔ many
    many ↔ many
    3R(27284102-27285591)
    2R(17677121-17679160)


    ENSEMBL Gene Tree for LOX (if available)
    TreeFam Gene Tree for LOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LOX gene
    LOXL22  CD62  CD163L12  LOXL42  CD1632  LOXL32  SSC5D2  PRSS122  
    CD5L2  SRCRB4D2  LOXL12  DMBT12  
    2 SIMAP similar genes for LOX using alignment to 4 protein entries:     LYOX_HUMAN (see all proteins):
    LOXL1    LOXL3

    Find genes that share paralogs with LOX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LOX (see all 334)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18004491,2,,4
    C,F,A,Hnon-pathogenic1121689882(-) CCTGCG/AGCCGC 4 /Q /R mis1 us2k1 ese321Minor allele frequency- A:0.17NS EA NA CSA WA EU 7283
    rs106502871,2
    C--121403870(+) aaaaa-/A/AA  
            
    aaaaa
    2 -- int1 trp31NA 2
    rs1128060351,2
    C--121404626(+) GGCGG-/CGGTGGGG 2 -- cds11Minor allele frequency- CGG:0.50CSA 2
    rs38348241,2
    C--121414817(+) GATTT-/A/TAAAAA 2 -- us2k1 tfbs33MN EA CSA 358
    rs732857781,2
    C,F--121415734(+) TGGAGG/ACTGAG 1 -- us2k12Minor allele frequency- A:0.08WA 120
    rs1892811371,2
    --121675226(+) GCTAGA/CATTAG 2 -- ds50010--------
    rs1127705851,2
    C,F--121675244(+) TGTGTG/ATATGT 2 -- ds50012Minor allele frequency- A:0.14CSA WA 120
    rs1820359151,2
    --121675266(+) TCTATA/GGTCAG 2 -- ds50010--------
    rs1850040121,2
    --121675309(+) GTGATG/TGTTCT 2 -- ds50010--------
    rs1909262431,2
    C--121675776(+) CCAAAA/TGACAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LOX (121398890 - 121414055 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LOX: --
    Human Gene Mutation Database (HGMD): LOX
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LOX
    DNA2.0 Custom Variant and Variant Library Synthesis for LOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153455    OMIM disorders: --

    9 diseases for LOX:    
    About MalaCards
    oral submucous fibrosis    occipital horn syndrome    intracranial aneurysm    menkes disease
    bronchogenic carcinoma    gingival overgrowth    hereditary cerebral hemorrhage with amyloidosis    amyotrophic lateral sclerosis
    pancreatic cancer

    4 diseases from the University of Copenhagen DISEASES database for LOX:
    Melanoma     Cutis laxa     Menkes disease     Atherosclerosis

    Find genes that share disorders with LOX           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LOX gene (see all 70)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    occipital horn syndrome 72.6 1 8638917 (1)
    menkes disease 70.3 3 1975662 (1), 8980283 (1), 12838205 (1)
    oral submucous fibrosis 60.6 6 8537914 (3), 10426196 (1), 18764858 (1)
    cutis laxa 55.5 2 9111998 (2)
    oxidase deficiency 48.7 2 9111998 (1), 15831618 (1)
    tumors 39.4 125 1737396 (5), 8137286 (3), 17685448 (3), 15374948 (3) (see all 62)
    cancer 37 47 17471532 (3), 11201293 (2), 17943411 (2), 8564968 (1) (see all 33)
    collagen fibril 36.5 4 8989253 (1), 16341622 (1), 17071617 (1), 7915281 (1)
    metastasis 31.9 53 19816945 (3), 16642001 (3), 19526206 (3), 17079439 (3) (see all 23)
    colon adenocarcinoma 28.9 1 16545574 (1)

    Genetic Association Database (GAD): LOX
    Human Genome Epidemiology (HuGE) Navigator: LOX (13 documents)

    Export disorders for LOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LOX gene, integrated from 10 sources (see all 576):
    (articles sorted by number of sources associating them with LOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2. (PubMed id 1685472)1, 2, 3, 9 Haemaelaeinen E.-R.... Kivirikko K.I. (Genomics 1991)
    2. Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene. (PubMed id 10391127)1, 2, 9 Contente S.... Friedman R.M. (Mol. Cell. Biochem. 1999)
    3. The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene). (PubMed id 1357535)1, 2, 9 Mariani T.J.... Deak S.B. (Matrix 1992)
    4. Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. (PubMed id 12750963)1, 4, 9 Yoneyama T....Inoue I. (J. Hum. Genet. 2003)
    5. Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers. (PubMed id 18764858)1, 4, 9 Shieh T.M....Liu C.J. (amp 2009)
    6. Mutations in the lysyl oxidase gene are not associated with amyotrophic lateral sclerosis. (PubMed id 11675877)1, 4, 9 Chioza B.A....RadunoviA8 A. (Amyotroph. Lateral Scler. Other Motor Neuron Disord. 2001)
    7. Structure of the human lysyl oxidase gene. (PubMed id 7902322)1, 2, 9 Haemaelaeinen E.-R.... Kivirikko K.I. (Genomics 1993)
    8. Characterization of the human lysyl oxidase gene locus. (PubMed id 1352776)1, 2, 9 Svinarich D.M....Krawetz S.A. (J. Biol. Chem. 1992)
    9. Lysyl oxidase 473 G&gt;A polymorphism and breast cancer susceptibility in Chinese Han population. (PubMed id 20929399)1, 4 Ren J....Huang T. (DNA Cell Biol. 2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4015 HGNC: 6664 AceView: LOX Ensembl:ENSG00000113083 euGenes: HUgn4015
    ECgene: LOX H-InvDB: LOX

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LOX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LOX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LOX gene:
    Search GeneIP for patents involving LOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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