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LOX Gene

protein-coding GIFtS: 57

GC05M121429

lysyl oxidase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
lysyl oxidase¹ ² ³
MGC105112²
protein-lysine 6-oxidase²
EC 1.4.3.13³

External Ids:	HGNC: 6664¹	Entrez Gene: 4015²	Ensembl: ENSG00000113083⁷	UniProtKB: P28300³

Search outside databases for aliases for LOX gene

Previous GC identifers: GC05M121103 GC05M121800 GC05M121432 GC05M121478

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LOX:

The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and

elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine

residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the

encoded protein may have a role in tumor suppression. (provided by RefSeq)

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300

Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to

fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in

tumor suppression

Gene Wiki entry for LOX (Lysyl oxidase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LOX gene upstream (promoter) region

:
AP-1 NF-1 Max1 c-Myc CREB deltaCREB c-Fos c-Jun IRF-1 NF-kappaB1

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for LOX:

MePH28510-1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2 Ensembl cytogenetic band: 5q23.2 HGNC cytogenetic band: 5q23.3-q31.2

LOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M121429: view genomic region (about GC identifiers)

Start:	121,398,890 bp from pter
End:	121,414,055 bp from pter
Size:	15,166 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.9 NT_034772.6

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300 (See protein sequence)

Recommended Name: Protein-lysine 6-oxidase precursor

Size: 417 amino acids; 46944 Da

Cofactor: Copper

Cofactor: Contains 1 lysine tyrosylquinone (By similarity)

Subcellular location: Secreted, extracellular space

Miscellaneous: The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via

interaction with tropoelastin (By similarity)

Secondary accessions: B2R5Q3 Q5FWF0

Post-translational modifications:

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a

topaquinone produced by oxidation of tyrosine¹

REFSEQ proteins: NP_002308.2

ENSEMBL proteins:

ENSP00000378862 ENSP00000231004

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abnova for HuPro® and/or Recombinant Proteins
	Origene Purified Recombinant Human Protein: LOX
	Novus Biologicals Protein for LOX
	Novus Biologicals Lysate for LOX
	Browse Sino Biological Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005581	collagen	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005634	nucleus	IEA	--

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Antibodies for LOX:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LOX
	Browse R&D Systems for Antibodies
	Monoclonal and Polyclonal Antibodies from Abnova (LOX)
	Origene Antibodies (see all 3): LOX
	Novus Biologicals Antibodies for LOX
	Browse antibodies at Epitomics

Assays for LOX:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Browse Enzo Life Sciences for kits & assays

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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LOX for domains About GeneDecksing

2 InterPro domains/families:

IPR001695 Lysyl_oxidase

IPR019828 Lysyl_oxidase_CS

Graphical View of Domain Structure for InterPro Entry P28300

ProtoNet protein and cluster: P28300

1 Blocks protein family: IPB001695 Lysyl oxidase

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300

Similarity: Belongs to the lysyl oxidase family

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LOX)
		Origene 29mer shRNA kits in GFP-retroviral vector: LOX Origene shRNA RFP: LOX Origene basic RS shRNA: LOX
		Applied Biosystems Silencer® siRNAs for LOX
		Sigma-Aldrich siRNA Panels and siRNA for LOX Sigma-Aldrich shRNA Panels and shRNA for LOX Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector: LOX Origene Myc/DDK tagged cDNA clones in CMV expression vector: LOX Origene untagged cDNA clones in CMV expression vector: LOX
		Browse Sino Biological Human cDNA Clones

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300

Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to

fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in

tumor suppression

Catalytic activity: Peptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2)

Enzyme Number (IUBMB): EC 1.4.3.13

Genatlas biochemistry entry for LOX:

lysyl oxidase,copper dependent,processed by BMP1 to the mature enzyme necessary for the formation of covalent

cross-links in collagen and elastic fibers

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004720	protein-lysine 6-oxidase activity	IEA	--
GO:0005507	copper ion binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	--	--

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LOX for ontologies About GeneDecksing

Animal Models: 7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lox):

behavior/neurological	cardiovascular system	homeostasis/metabolism	lethality-prenatal/perinatal	muscle
respiratory system	skin/coat/nails

LOX for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LOX

5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001568	blood vessel development	IEA	--
GO:0006464	protein modification process	TAS	1685472
GO:0030199	collagen fibril organization	IEA	--
GO:0030324	lung development	IEA	--
GO:0042060	wound healing	IEA	--

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LOX for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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LOX for compounds About GeneDecksing

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LOX
10/524 Novoseek chemical compound relationships for LOX gene (see all 524 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
beta-aminopropionitrile	100.00	87	19524603 (3), 18586678 (3), 7544946 (2), 6141164 (2) (see all 71)
arachidonic acid	89.95	157	8485318 (4), 15931672 (4), 11406473 (4), 9467967 (3) (see all 100)
ndga	88.38	64	16118472 (3), 9258337 (2), 18719338 (2), 15801029 (2) (see all 55)
copper	78.58	169	16635319 (9), 9355764 (6), 1674861 (6), 10573541 (6) (see all 96)
amine	52.94	72	2571459 (4), 11642359 (4), 235299 (3), 18835815 (3) (see all 54)
linoleic acid	40.20	58	9693089 (4), 7810887 (3), 17117812 (3), 10574694 (3) (see all 43)
jasmonic acid	37.42	35	16168955 (4), 19522815 (3), 14991649 (3), 9927708 (2) (see all 24)
methyljasmonate	23.91	21	14682619 (4), 12126709 (3), 17611116 (2), 14697246 (2) (see all 13)
desmosine	22.17	15	12918034 (2), 6170751 (1), 6102412 (1), 30449 (1) (see all 14)
hydroxylysine	17.45	13	9681684 (1), 906929 (1), 9031521 (1), 8530522 (1) (see all 13)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LOX)
		Applied Biosystems Silencer® siRNAs: NM_002317
		Origene 29mer shRNA kits in GFP-retroviral vector: LOX Origene shRNA RFP: LOX Origene basic RS shRNA: LOX
		Sigma-Aldrich siRNA Panels and siRNA for LOX Sigma-Aldrich shRNA Panels and shRNA for LOX Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:		1 SABiosciences microRNA that regulate LOX:
		hsa-miR-145

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_002317

Clones:

Origene GFP tagged cDNA clones in CMV expression vector: LOX
Origene Myc/DDK tagged cDNA clones in CMV expression vector: LOX
Origene untagged cDNA clones in CMV expression vector: LOX

Primers:		Origene genome-wide validated SYBR primer pairs: LOX
		SABiosciences RT2 qPCR Primer Assay for LOX: PPH01956A

REFSEQ mRNAs for LOX gene:

NM_002317.4

Additional cDNA sequence:

AF039291.1 AK297709.1 AK298781.1 AK307559.1 AK307732.1 AK311354.1 AK312269.1 AK315873.1

AK316309.1 BC074820.2 BC074872.2 BC089436.1 CR591353.1 M94054.1 S45875.1 S78694.1

14 DOTS entries:

DT.454042 DT.92428708 DT.100019519 DT.95273505 DT.120804894 DT.120804911 DT.120804946 DT.120804902

DT.120804943 DT.92428700 DT.102829366 DT.120804908 DT.95273508 DT.99970925

24/354 AceView cDNA sequences (see all 354 ):

AI343556 AI954506 CA412280 AA599304 AI141565 AI755066 AI831839 AA515402

BF112095 AI924187 CA418190 CA419687 AI752963 CA421542 AL711116 N24205

W70343 AI075382 H99862 AI075456 BU634047 BM997672 W77730 CF264898

highest scoring ESTs for LOX:

AA022565 AA039556 AA194911 AA195621 AA235754 AA235755 AA236779 AA236819 AA334844 AA410518

Unigene Cluster for LOX:

Lysyl oxidase

Hs.102267 [show with all ESTs]

Unigene Representative Sequence: NM_002317

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LOX (see all 6 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	^	10
SP1:					-		-				-						-
SP2:					-		-		-		-
SP3:									-		-						-
SP4:											-						-
SP5:																	-

About this scheme

ECgene alternative splicing isoforms for LOX

2 Ensembl transcripts including schematic representations:

ENST00000395480 ENST00000231004

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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LOX expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LOX

¹ / ² / ³

9 probe-sets matching LOX gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44846_r_at²^{, 3}	U95-B	1	0.88	1.00	0.81	0.89	AI760939	0.40	1.00	0.76	1
38637_at²^{, 3}	U95-A	1	0.75	1.00	0.91	1.16	L16895	0.20	1.00	0.72	1
44845_i_at²^{, 3}	U95-B	1	0.71	1.00	0.91	0.99	AI760939	0.40	1.00	0.76	1
213640_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE503425	0.80	1.00	0.91	1
215446_s_at²^{, 3}	U133-A	1	0.82	1.00	--	--	L16895	0.20	1.00	0.72	1
204298_s_at²^{, 3}	U133-A	1	0.82	1.00	--	--	NM_002317	0.60	1.00	0.82	1
213640_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215446_s_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--
204298_s_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

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Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: TATGTATTTC

SOURCE GeneReport for Unigene cluster: Hs.102267

Expression variation in blood from EXPOLDB for LOX

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300

Tissue specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas

Primers:		Origene genome-wide validated SYBR primer pairs: LOX
		SABiosciences RT2 qPCR Primer Assay for LOX: PPH01956A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for LOX gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOX¹	--	lysyl oxidase	89.54(n) 92.89(a)	481478 XM_538599.2 XP_538599.2
chimpanzee (Pan troglodytes)	LOX¹	--	lysyl oxidase	99.2(n) 99.04(a)	471614 XM_001153015.1 XP_001153015.1
cow (Bos taurus)	LOX¹	--	lysyl oxidase	88.62(n) 90.84(a)	280841 NM_173932.2 NP_776357.1
rat (Rattus norvegicus)	Lox¹	--	lysyl oxidase	82.56(n) 86.37(a)	24914 NM_017061.1 NP_058757.1
mouse (Mus musculus)	Lox^{1, 5}	18 (29.00 cM)⁵	lysyl oxidase^{1, 5}	84.35(n)¹ 87.35(a)¹	16948¹ NM_010728.1¹ NP_034858.1¹ AI893619⁵ AK135213⁵ (see all 27)

About this table Species with no ortholog for LOX

ENSEMBL Gene Tree for LOX

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for LOX gene

LOXL2² MARCO² CD6² LOXL4² CD163L1² CD163² LOXL3² PRSS12²

SSC5D² CD5L² SRCRB4D² LOXL1² MSR1² SCARA5² LOC619207² DMBT1²

LOX for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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2 NCBI SNPs in LOX are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
--	rs840466^1,2	C,F,H	116607498(-)	`TTGGGG/TGACGG`	1	--	ng5¹		4	NA	78
--	rs840467^1,2	C,H	116607476(-)	`GATCCG/ATGTAG`	1	--	ng5¹		3	NA	6

About this table
The following additional 64 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs2979862	rs2913403	rs10519694	rs3792801	rs2914604	rs2956540	rs2731646
rs10054785	rs2913400	rs2914599	rs3805442	rs2979865	rs2914611	rs995689
rs2914600	rs3763024	rs2956537	rs840462	rs17431081	rs10059661	rs2913399
rs3792803	rs17352686	rs2979872	rs995687	rs10519692	rs3853401	rs17352097
rs2913405	rs2979864	rs2979868	rs13173506	rs840460	rs2913407	rs2979867
rs1800449	rs2288393	rs10056720	rs17352083	rs2979860	rs2913406	rs2731647
rs2303656	rs2278226	rs17148773	rs10053942	rs2956538	rs995688	rs2913401
rs35146783	rs34226651	rs2913402	rs864548	rs3805443	rs2979870	rs6879333
rs10519693	rs13184805	rs2956539	rs840464	rs11956933	rs840461	rs2913396
rs10040971

HapMap Linkage Disequilibrium images for LOX (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LOX: --

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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LOX for disorders About GeneDecksing

OMIM: 153455 disorders: 219100

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300

Defects in LOX may be a cause of autosomal recessive cutis laxa type I (CL type I) [MIM:219100]

10/290 Novoseek disease relationships for LOX gene (see all 290 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
menkes	22.19	19	6112984 (5), 17584760 (3), 9556668 (2), 8638917 (2) (see all 10)
oral submucous fibrosis	18.65	15	8537914 (5), 10426196 (4), 18764858 (3), 12101112 (2) (see all 5)
ehlers-danlos syndrome type v	9.00	3	7086195 (1), 240645 (1), 1448 (1)
cutis laxa	8.10	7	953234 (1), 9111998 (1), 7930686 (1), 7508709 (1) (see all 7)
occipital horn syndrome	7.36	4	8638917 (2), 6104292 (1), 11431706 (1)
pelvic organ prolapse	6.02	8	19087518 (5), 16419630 (3)
oropharyngeal squamous cell carcinoma	5.95	5	19816945 (5)
retinal detachment rhegmatogenous	5.04	7	18566459 (4), 19369240 (3)
invasive breast cancer	4.45	9	16357151 (4), 17685448 (3), 17130123 (1), 16440329 (1)
fibrosis liver	3.83	12	26918 (2), 1683640 (2), 8698196 (1), 7899140 (1) (see all 10)

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Human Gene Mutation Database: LOX
Genetic Association Database: LOX
Human Genome Epidemiology Navigator: LOX (10 documents)

(Possibly Related Articles in Doctor's Guide)
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EULAR: New Anti-inflammatory, Licofelone, Shows Similar Efficacy and Possibly Better Safety than Other NSAIDs

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/556 PubMed articles for LOX gene (see all 556 ):

Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2. (PubMed id 1685472)^{1, 2, 3, 4} Haemaelaeinen E.-R.... Kivirikko K.I. (1991)
Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene. (PubMed id 10391127)^{1, 3, 4} Contente S.... Friedman R.M. (1999)
Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. (PubMed id 12750963)^{1, 3, 6} Yoneyama T....Inoue I. (2003)
Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. (PubMed id 12101112)^{1, 3, 6} Chiu C.J....Chen C.J. (2002)
Congenital cutis laxa and lysyl oxidase deficiency. (PubMed id 9111998)^{1, 3, 4} Khakoo A.... Pope F.M. (1997)
Mutations in the lysyl oxidase gene are not associated with amyotrophic lateral sclerosis. (PubMed id 11675877)^{1, 3, 6} Chioza B.A....Radunovic A. (2001)
A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene. (PubMed id 8100215)^{1, 3, 4} Csiszar K.... Boyd C.D. (1993)
Structure of the human lysyl oxidase gene. (PubMed id 7902322)^{1, 3, 4} Haemaelaeinen E.-R.... Kivirikko K.I. (1993)
The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene). (PubMed id 1357535)^{1, 3, 4} Mariani T.J.... Deak S.B. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4015	HGNC: 6664	AceView: LOX	Ensembl:ENSG00000113083	euGenes: HUgn4015
ECgene: LOX	H-InvDB: LOX

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for LOX	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LOX gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for LOX gene:

Search GeneIP for patents involving LOX

GeneCards and IP:

Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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Products for LOX:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LOX		Antibodies for LOX
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LOX		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		Browse ELISAs at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search for Antibodies & Assays

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	Custom immunoassay development

Search Tocris compounds for LOX

	Regulatory tfbs in LOX upstream (promoter) region
	Search Chromatin IP Primers for LOX
	DNA Methylation qPCR Primer Assays for LOX
	RT2 qPCR Primer Assay for LOX
	GNC Network for LOX
	microRNAs that regulate LOX

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for LOX
	Proteins for LOX
	Lysates for LOX

Browse antibodies at Epitomics

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

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GeneCards Homepage - Last full update: 21 May 2010 - Incremental updates: 24 May 2010 , 20 Jun 2010

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Category			ACSF3 acyl-CoA synthetase family member 3
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

LOX gene at Home site.

hostname: server4.xennexinc.com db build: 72 index build: 72d solr: 1.4

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LOX Gene

protein-coding GIFtS: 57

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aspergillus flavus infection
bronchogenic carcinoma
malformation
lung tumor
leydig cell hyperplasia
k deficiency
myelofibrosis
h pylori infection
cutis laxa
bronchioloalveolar carcinoma
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arteriopathy
atherosclerosis
nonsense mutation
colorectal adenocarcinoma
neuroblastoma
malignant disease
diabetes mellitus insulin-dependent
disease; liver
failure heart
ovarian cancer
cirrhosis (liver)
depigmentation
large cell carcinoma
diabetic complication
atherogenesis
sclerosis; systemic
abdominal aortic aneurysm
exostoses
fibrosis liver
psoriasis
dupuytren
sclc
metabolic syndrome
retinal detachment rhegmatogenous
connective tissue defect
metastasis
cell injury
necrosis
acidosis
copper deficiency
direct hernia
lymph node metastasis
neoplastic transformation
infection induced
chronic disease
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colon cancer
disease; eye
desmoplasia
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exfoliation syndrome
disease; wilsons
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escc
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aneurysm intracranial
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damage liver
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growth suppression
benign prostatic hypertrophy
distortion
heritable connective tissue disorder
hepatic granuloma
inflammatory disease
diabetic retinopathy proliferative
multiple disorders
lung cancer
autoimmune disease
breast cancer
infarction; myocardial
hypercholesterolemia
emphysema
tumor promotion
mitochondrial dna deletion
internal jugular phlebectasia
carcinosarcoma
colonic adenoma
somatic mutation
shock
colon adenocarcinoma
osteogenesis imperfecta, perinatal lethal
colorectal cancer
dominant-negative mutant
healing ulcer
hnscc
hypertension
CHF
cysts
hepatitis
oral cancer
hyperglycemia
cancer other
occipital horn syndrome
diastolic dysfunction
thrombosis
extravasation
innate immune response
cardiovascular disease
breast cancer metastatic
colon tumor
huntington disease
gastric cancer
melanoma
glaucoma
tumor progression
keloids
bone tumor
carcinoma; renal cell
hepatitis chronic acute
disease parkinsons
aneurysm; arterial
disease; inflammatory bowel
fibrosis pulmonary
photosensitized
ichthyosis
ehlers-danlos syndrome type v
schistosomiasis
kearns-sayre syndrome
ovary; polycystic (syndrome)
choroidal melanoma
aneurysm aortic
pelvic organ prolapse
solid tumor
osteogenesis imperfecta
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amelanotic melanoma
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aortic regurgitation
obstruction
cancer
tumor necrosis
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hypertension pulmonary
aneurysm
dermatosparaxis
growth arrest
ehlers-danlos syndrome type vi
cell transformation
ulcer
precancerous lesions
subfertility
colorectal adenoma
alveolar echinococcosis
cardiomyopathy dilated
corneal dystrophy, granular type
arterial restenosis
endothelial dysfunction
bladder transitional cell carcinoma
aneurysm, thoracic
fibrosarcoma
chronic osteoarthritis
meningeal tumor
skin tumor
hyperplasia
connective tissue disease
atherosclerotic plaque
RA
infarct
igg myeloma
hyperparathyroidism
estrogen deficiency
squamous cell carcinoma
leukemia
paraplegia
oropharyngeal squamous cell carcinoma
arteriosclerosis
pancreatic cancer
pregnancy early
nonalcoholic steatohepatitis
chronic renal failure
hypertrophies
colorectal tumor
contracture flexion
ischemic stroke
CAD
deficiency; protein
fungal infection
malignant transformation
dcis
inflammatory response
skin carcinogenesis
tumor angiogenesis
corneal disease
osteochondrosis
urological cancer
sclerosis
hypoxic
oral submucous fibrosis
diabetes; type 2
cancer cell growth
asthma
adenocarcinoma
spontaneous rupture
bronchopulmonary dysplasia
fracture pathological
anabolic steroids
scleroderma
ehrlich ascites tumor
deficiency; pyridoxine
bone lesion
inflammation
tracheobronchomegalies
pseudoxanthoma elasticum
hyperhomocysteinemia
hepatitis b
vascular calcification
hypofunction
prostate cancer
carcinoma hepatocellular
sarcoma
disease; ischemic heart
adjuvant arthritis
carpal tunnel syndrome
disease; skin
dwarf
marfan syndrome
bronchiolitis; obliterative
alcohol; liver
bladder cancer
invasive carcinoma
mammary adenocarcinoma
chronic persistent hepatitis
osteoarthritis
neurodegeneration
breast tumor
calcification
artery dissection
invasive ductal carcinoma
ALS
tumorigenicity
skin cancer
blight
AD
pathological angiogenesis
homocystinuria
nephropathies
restenosis
cardiac hypertrophy
allelic imbalance
stroke
infection; intrauterine
infectious
chronic liver disease
congenital cutis laxa
genetic disorder
dystrophy (muscular)
bone metastases
arthritis

Advanced Search (alpha)

LOX Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor LOX gene

Summariesfor LOX gene

Genomic Viewsfor LOX gene

Proteinsfor LOX gene

Protein Domains/Familiesfor LOX gene

Gene Functionfor LOX gene

Pathways & Interactionsfor LOX gene

Drugs & Compoundsfor LOX gene

Transcriptsfor LOX gene

Expression for LOX gene

Orthologsfor LOX gene

Paralogsfor LOX gene

Genomic Variantsfor LOX gene

Disorders & Mutationsfor LOX gene

Medical Newsfor LOX gene

Publicationsfor LOX gene

Search for LOX gene

Genome Databases showing LOX gene

Other Databases showing LOX gene

Specialized Databases showing LOX gene

Intellectual Propertyfor LOX gene

Servicesfor LOX gene

View Random Gene

Aliases &
Descriptions
for LOX gene

Summaries
for LOX gene

Genomic Views
for LOX gene

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Families
for LOX gene

Gene Function
for LOX gene

Pathways & Interactions
for LOX gene

Drugs & Compounds
for LOX gene

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for LOX gene

Expression
for LOX gene

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Medical News
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