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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LOX Gene

protein-coding   GIFtS: 65
GCID: GC05M121429

Lysyl Oxidase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lysyl Oxidase1 2 3
EC 1.4.3.133 8
Protein-Lysine 6-Oxidase2

External Ids:    HGNC: 66641   Entrez Gene: 40152   Ensembl: ENSG000001130837   OMIM: 1534555   UniProtKB: P283003   

Export aliases for LOX gene to outside databases

Previous GC identifers: GC05M121103 GC05M121800 GC05M121432 GC05M121478 GC05M116590


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LOX Gene:
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens
and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and
hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular
matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of
autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, May 2010)

GeneCards Summary for LOX Gene: 
LOX (lysyl oxidase) is a protein-coding gene. Diseases associated with LOX include oral submucous fibrosis, and occipital horn syndrome, and among its related super-pathways are Collagen formation and Molecules associated with elastic fibres. GO annotations related to this gene include protein-lysine 6-oxidase activity and copper ion binding. An important paralog of this gene is LOXL2.

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300
Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors
to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct
role in tumor suppression

Gene Wiki entry for LOX (Lysyl oxidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LOX gene promoter:
         NF-1   STAT1   AP-1   ATF-2   Nkx2-5   IRF-1   deltaCREB   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLOX promoter sequence
   Search SABiosciences Chromatin IP Primers for LOX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.2   Ensembl cytogenetic band:  5q23.2   HGNC cytogenetic band: 5q23.3-q31.2

LOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOX gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M121429:  view genomic region     (about GC identifiers)

Start:
121,398,890 bp from pter      End:
121,414,055 bp from pter
Size:
15,166 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300 (See protein sequence)
Recommended Name: Protein-lysine 6-oxidase precursor  
Size: 417 amino acids; 46944 Da
Cofactor: Copper
Cofactor: Contains 1 lysine tyrosylquinone (By similarity)
Subcellular location: Secreted, extracellular space
Miscellaneous: The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via
interaction with tropoelastin (By similarity)
Secondary accessions: B2R5Q3 Q5FWF0

Explore the universe of human proteins at neXtProt for LOX: NX_P28300

Explore proteomics data for LOX at MOPED 

Post-translational modifications:

  • UniProtKB: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine
    with a topaquinone produced by oxidation of tyrosine
  • UniProtKB: Proteolytically activated by BMP1 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28300

  • 4/9 DME Specific Peptides for LOX (P28300) (see all 9)
     QASTYVQ  AAPGAWRQ  PGNYILKV  IQWENNGQV 

    LOX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LOX Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171573.1  NP_002308.2  

    ENSEMBL proteins: 
     ENSP00000231004   ENSP00000427538  
    Reactome Protein details: P28300
    Human Recombinant Protein Products for LOX: 
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    Novus Biologicals LOX Proteins
    Novus Biologicals LOX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LOX 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005581collagen IEA--
    GO:0005615extracellular space IEA--
    GO:0005634nucleus IEA--

    LOX for ontologies           About GeneDecksing



    LOX Antibody Products: 
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    Cloud-Clone Corp. Antibodies for LOX 
    ThermoFisher Antibody for LOX
    LSBio Antibodies in human, mouse, rat for LOX 

    Assay Products for LOX: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LOX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LOX 
    Cloud-Clone Corp. CLIAs for LOX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001695 Lysyl_oxidase
     IPR019828 Lysyl_oxidase_CS

    Graphical View of Domain Structure for InterPro Entry P28300

    ProtoNet protein and cluster: P28300

    1 Blocks protein domain: IPB001695 Lysyl oxidase

    UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300
    Similarity: Belongs to the lysyl oxidase family


    LOX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LYOX_HUMAN, P28300
    Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors
    to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct
    role in tumor suppression
    Catalytic activity: Peptidyl-L-lysyl-peptide + O(2) + H(2)O = peptidyl-allysyl-peptide + NH(3) + H(2)O(2)

         Genatlas biochemistry entry for LOX:
    lysyl oxidase,copper dependent,processed by BMP1 to the mature enzyme necessary for the formation of covalent
    cross-links in collagen and elastic fibers

         Enzyme Number (IUBMB): EC 1.4.3.131 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004720protein-lysine 6-oxidase activity IEA--
    GO:0005507copper ion binding IEA--
    GO:0005515protein binding IPI19570982
    GO:0016641oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor ----
         
    LOX for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LOX:
     Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lox):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  integument  mortality/aging 
     muscle  respiratory system 

    LOX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LOX: Loxtm1Soin Loxtm1Ikh

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LOX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LOX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LOX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LOX 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LOX
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate LOX (see all 55):
    hsa-miR-411* hsa-miR-21* hsa-miR-379* hsa-miR-429 hsa-miR-4272 hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidLOX 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of LOX

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    GenScript: all cDNA clones in your preferred vector: LOX (NM_000697)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOX
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                         Customized lentivirus expression plasmids for stable overexpression of LOX 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LOX About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen formation0.74
    Extracellular matrix organization0.39
    Assembly of collagen fibrils and other multimeric structures0.65
    2Elastic fibre formation
    Elastic fibre formation0.84
    3Crosslinking of collagen fibrils
    Crosslinking of collagen fibrils

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for LOX
        Extracellular matrix organization
    Assembly of collagen fibrils and other multimeric structures
    Crosslinking of collagen fibrils
    Elastic fibre formation
    Collagen formation



    LOX for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LOX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/13 Interacting proteins for LOX (P283001, 3 ENSP000002310044) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELNP155021, 3, ENSP000002520344EBI-3893481,EBI-1222108 I2D: score=2 STRING: ENSP00000252034
    DHDDSQ86SQ93, ENSP000003531044I2D: score=2 STRING: ENSP00000353104
    DPTQ075073, ENSP000003567914I2D: score=2 STRING: ENSP00000356791
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    HIST1H1BP164013, ENSP000003300744I2D: score=1 STRING: ENSP00000330074
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568blood vessel development IEA--
    GO:0006464cellular protein modification process TAS1685472
    GO:0009725response to hormone stimulus ----
    GO:0030198extracellular matrix organization TAS--
    GO:0030199collagen fibril organization IEA--

    LOX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LOX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LOX (LYOX)

    5 HMDB Compounds for LOX    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    CopperCu (see all 2)7440-50-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/104 Novoseek inferred chemical compound relationships for LOX gene (see all 104)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-aminopropionitrile 92.5 41 19661442 (2), 1358170 (2), 19440335 (2), 14550642 (1) (see all 23)
    ndga 78.8 43 15801029 (2), 10600514 (2), 12929751 (1), 16406549 (1) (see all 26)
    arachidonic acid 78.7 114 8485318 (4), 15801029 (3), 9369949 (3), 9467967 (3) (see all 71)
    desmosine 77.2 6 18158636 (1), 18847364 (1), 12163653 (1)
    hydroxylysine 75.8 13 7902322 (1), 15652501 (1), 19247601 (1), 1685472 (1) (see all 8)
    alpha-aminoadipic semialdehyde 75.3 5 1680355 (1), 16909208 (1), 1357535 (1), 7899140 (1)
    rev 5901 75.2 4 10600514 (2), 16406549 (1), 18927292 (1)
    aa861 74 7 16903934 (2), 16406549 (1), 15931672 (1), 18765235 (1) (see all 6)
    baicalein 71.8 9 10600514 (2), 17164225 (1), 15931672 (1), 12481414 (1) (see all 7)
    topaquinone 70 2 14967060 (1)

    Search CenterWatch for drugs/clinical trials and news about LOX / LYOX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LOX gene (2 alternative transcripts): 
    NM_001178102.1  NM_002317.5  

    Unigene Cluster for LOX:

    Lysyl oxidase
    Hs.102267  [show with all ESTs]
    Unigene Representative Sequence: NM_002317
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231004(uc010jcp.3 uc010jcq.3 uc010jcr.3 uc011cwk.2 uc003ksu.3)
    ENST00000513319 ENST00000505593 ENST00000503759 ENST00000508067

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate LOX (see all 55):
    hsa-miR-411* hsa-miR-21* hsa-miR-379* hsa-miR-429 hsa-miR-4272 hsa-miR-199a-3p hsa-miR-513a-5p hsa-miR-128
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    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: LOX (NM_000697)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOX
    Sirion Biotech Customized lentivirus for stable overexpression of LOX 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LOX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LOX

    Additional mRNA sequence: 

    AF039291.1 AK307559.1 AK307732.1 AK311354.1 AK312269.1 AK315873.1 AK316309.1 BC074820.2 
    BC074872.2 BC089436.1 M94054.1 S45875.1 S78694.1 

    15 DOTS entries:

    DT.454042  DT.102829366  DT.100019519  DT.92428708  DT.120804946  DT.95273505  DT.120804894  DT.120804911 
    DT.120804882  DT.120804902  DT.120804908  DT.120804943  DT.121636432  DT.92428700  DT.99970925 

    24/354 AceView cDNA sequences (see all 354):

    AI376052 BM676929 AI829648 BQ447108 BU634047 CA417519 BQ774743 H98150 
    BU615699 CA445466 CA843026 AI435851 AI752963 CA419687 BC074820 W77730 
    AI075456 BQ774715 AI075382 CA414453 BM669852 CF131327 CA425702 AU102655 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LOX (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10
    SP1:              -     -           -                 -                                                   
    SP2:              -     -     -     -                                                                     
    SP3:                          -     -                 -                                                   
    SP4:                                -                 -                                                   
    SP5:                                                  -                                                   


    ECgene alternative splicing isoforms for LOX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LOX expression in normal human tissues (normalized intensities)      LOX embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTATTTC
    LOX Expression
    About this image


    LOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Atrioventricular Node Cells Atrioventricular Node
             heart/atrium   
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Human umbilical vein endothelial cells (HUVEC)
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Fibroblast
             Detroit 551
             X-gene Foreskin Fibroblasts   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Foregut
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   

    See LOX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LOX

    SOURCE GeneReport for Unigene cluster: Hs.102267

    UniProtKB/Swiss-Prot: LYOX_HUMAN, P28300
    Tissue specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including LOX: 
              Fibrosis in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for LOX gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lox1 , 5 lysyl oxidase1, 5 84.43(n)1
    87.59(a)1
      18 (28.22 cM)5
    169481  NM_010728.21  NP_034858.21 
     525172385 
    chicken
    (Gallus gallus)
    Aves LOX1 lysyl oxidase 73.8(n)
    77.83(a)
      396474  NM_205481.1  NP_990812.1 
    lizard
    (Anolis carolinensis)
    Reptilia LOX6
    lysyl oxidase
    71(a)
    1 ↔ 1
    GL343193.1(11729840-11748537)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.114272 Transcribed sequence with moderate similarity to protein more 73.52(n)    BG302899.1 


    ENSEMBL Gene Tree for LOX (if available)
    TreeFam Gene Tree for LOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LOX gene
    LOXL22  CD62  CD163L12  LOXL42  CD1632  LOXL32  SSC5D2  PRSS122  
    CD5L2  SRCRB4D2  LOXL12  DMBT12  
    2 SIMAP similar genes for LOX using alignment to 4 protein entries:     LYOX_HUMAN (see all proteins):
    LOXL1    LOXL3

    LOX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/334 SNPs in LOX are shown (see all 334)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18004491,2,4
    C,F,A,Hnon-pathogenic1121689882(-) CCTGCG/AGCCGC 4 /Q /R mis1 us2k1 ese321Minor allele frequency- A:0.17NS EA NA CSA WA EU 7283
    rs106502871,2
    C--121403870(+) aaaaa-/A/AA  
            
    aaaaa
    2 -- int1 trp31NA 2
    rs1128060351,2
    C--121404626(+) GGCGG-/CGGTGGGG 2 -- cds11Minor allele frequency- CGG:0.50CSA 2
    rs38348241,2
    C--121414817(+) GATTT-/A/TAAAAA 2 -- us2k1 tfbs33MN EA CSA 358
    rs732857781,2
    C,F--121415734(+) TGGAGG/ACTGAG 1 -- us2k12Minor allele frequency- A:0.08WA 120
    rs1892811371,2
    --121675226(+) GCTAGA/CATTAG 2 -- ds50010--------
    rs1127705851,2
    C,F--121675244(+) TGTGTG/ATATGT 2 -- ds50012Minor allele frequency- A:0.14CSA WA 120
    rs1820359151,2
    --121675266(+) TCTATA/GGTCAG 2 -- ds50010--------
    rs1850040121,2
    --121675309(+) GTGATG/TGTTCT 2 -- ds50010--------
    rs1909262431,2
    C--121675776(+) CCAAAA/TGACAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LOX (121398890 - 121414055 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LOX: --

    Human Gene Mutation Database (HGMD): LOX
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LOX
    DNA2.0 Custom Variant and Variant Library Synthesis for LOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 153455    OMIM disorders: --

    20/88 diseases for LOX (see all 88):    About MalaCards
    oral submucous fibrosis    occipital horn syndrome    menkes disease    bronchogenic carcinoma
    intracranial aneurysm    gingival overgrowth    wilson disease    cutis laxa
    marfan syndrome    exfoliation syndrome    keloids    alk-positive anaplastic large cell lymphoma
    congenital ichthyosiform erythroderma    colonic polyps    retinal detachment    gingivitis
    ischemic heart disease    homocystinuria    eye disease    ehlers-danlos syndrome

    4 diseases from the University of Copenhagen DISEASES database for LOX:
    Melanoma     Cutis laxa     Menkes disease     Atherosclerosis

    LOX for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/70 Novoseek inferred disease relationships for LOX gene (see all 70)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    occipital horn syndrome 72.6 1 8638917 (1)
    menkes disease 70.3 3 1975662 (1), 8980283 (1), 12838205 (1)
    oral submucous fibrosis 60.6 6 8537914 (3), 10426196 (1), 18764858 (1)
    cutis laxa 55.5 2 9111998 (2)
    oxidase deficiency 48.7 2 9111998 (1), 15831618 (1)
    tumors 39.4 125 1737396 (5), 8137286 (3), 17685448 (3), 15374948 (3) (see all 62)
    cancer 37 47 17471532 (3), 11201293 (2), 17943411 (2), 8564968 (1) (see all 33)
    collagen fibril 36.5 4 8989253 (1), 16341622 (1), 17071617 (1), 7915281 (1)
    metastasis 31.9 53 19816945 (3), 16642001 (3), 19526206 (3), 17079439 (3) (see all 23)
    colon adenocarcinoma 28.9 1 16545574 (1)

    Genetic Association Database (GAD): LOX
    Human Genome Epidemiology (HuGE) Navigator: LOX (13 documents)

    Export disorders for LOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LOX gene, integrated from 9 sources (see all 568):
    (articles sorted by number of sources associating them with LOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2. (PubMed id 1685472)1, 2, 3, 9 Haemaelaeinen E.-R.... Kivirikko K.I. (1991)
    2. Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene. (PubMed id 10391127)1, 2, 9 Contente S.... Friedman R.M. (1999)
    3. The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene). (PubMed id 1357535)1, 2, 9 Mariani T.J.... Deak S.B. (1992)
    4. Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. (PubMed id 12750963)1, 4, 9 Yoneyama T....Inoue I. (2003)
    5. Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers. (PubMed id 18764858)1, 4, 9 Shieh T.M....Liu C.J. (2008)
    6. Mutations in the lysyl oxidase gene are not associated with amyotrophic lateral sclerosis. (PubMed id 11675877)1, 4, 9 Chioza B.A....Radunovic A. (2001)
    7. Structure of the human lysyl oxidase gene. (PubMed id 7902322)1, 2, 9 Haemaelaeinen E.-R.... Kivirikko K.I. (1993)
    8. Characterization of the human lysyl oxidase gene locus. (PubMed id 1352776)1, 2, 9 Svinarich D.M....Krawetz S.A. (1992)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    10. Lysyl Oxidase 473 G>A Polymorphism and Breast Canc er Susceptibility in Chinese Han Population. (PubMed id 20929399)1, 4 Ren J....Huang T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4015 HGNC: 6664 AceView: LOX Ensembl:ENSG00000113083 euGenes: HUgn4015
    ECgene: LOX H-InvDB: LOX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LOX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LOX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LOX gene:
    Search GeneIP for patents involving LOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Regulatory tfbs in LOX promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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