External Ids for LOX Gene
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
GeneCards Summary for LOX Gene
LOX (Lysyl Oxidase) is a Protein Coding gene. Diseases associated with LOX include oral submucous fibrosis and occipital horn syndrome. Among its related pathways are Degradation of the extracellular matrix and Elastic fibre formation. GO annotations related to this gene include copper ion binding and protein-lysine 6-oxidase activity. An important paralog of this gene is LOXL1.
UniProtKB/Swiss-Prot for LOX Gene
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression