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Aliases for LONRF3 Gene

Aliases for LONRF3 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 3 2 3
  • Ring Finger Protein 127 2 3
  • RNF127 3 4
  • LON Peptidase N-Terminal Domain And RING Finger Protein 3 3
  • RING Finger Protein 127 4

External Ids for LONRF3 Gene

Previous Symbols for LONRF3 Gene

  • RNF127

Summaries for LONRF3 Gene

Entrez Gene Summary for LONRF3 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008]

GeneCards Summary for LONRF3 Gene

LONRF3 (LON Peptidase N-Terminal Domain And Ring Finger 3) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LONRF3 Gene

Genomics for LONRF3 Gene

Genomic Location for LONRF3 Gene

Start:
118,974,614 bp from pter
End:
119,018,355 bp from pter
Size:
43,742 bases
Orientation:
Plus strand

Genomic View for LONRF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LONRF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF3 Gene

Regulatory Elements for LONRF3 Gene

Proteins for LONRF3 Gene

  • Protein details for LONRF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q496Y0-LONF3_HUMAN
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 3
    Protein Accession:
    Q496Y0
    Secondary Accessions:
    • Q5JPN6
    • Q8NB00
    • Q9H647

    Protein attributes for LONRF3 Gene

    Size:
    759 amino acids
    Molecular mass:
    84490 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15419.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LONRF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LONRF3 Gene

Proteomics data for LONRF3 Gene at MOPED

Post-translational modifications for LONRF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LONRF3 Gene

No data available for DME Specific Peptides for LONRF3 Gene

Domains for LONRF3 Gene

Gene Families for LONRF3 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

UniProtKB/Swiss-Prot:

LONF3_HUMAN
Domain:
  • Contains 1 Lon domain.:
    • Q496Y0
Similarity:
  • Contains 2 RING-type zinc fingers.:
    • Q496Y0
  • Contains 4 TPR repeats.:
    • Q496Y0
genes like me logo Genes that share domains with LONRF3: view

Function for LONRF3 Gene

Gene Ontology (GO) - Molecular Function for LONRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004176 ATP-dependent peptidase activity IEA --
GO:0005515 protein binding IPI 20195357
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with LONRF3: view
genes like me logo Genes that share phenotypes with LONRF3: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LONRF3 Gene

Localization for LONRF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LONRF3 Gene COMPARTMENTS Subcellular localization image for LONRF3 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for LONRF3 Gene

Pathways for LONRF3 Gene

SuperPathways for LONRF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LONRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with LONRF3: view

No data available for Pathways by source for LONRF3 Gene

Transcripts for LONRF3 Gene

Unigene Clusters for LONRF3 Gene

LON peptidase N-terminal domain and ring finger 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - -
SP3: - - -
SP4: - - - -

Relevant External Links for LONRF3 Gene

GeneLoc Exon Structure for
LONRF3
ECgene alternative splicing isoforms for
LONRF3

Expression for LONRF3 Gene

mRNA expression in normal human tissues for LONRF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LONRF3 Gene

This gene is overexpressed in Muscle - Skeletal (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LONRF3 Gene

SOURCE GeneReport for Unigene cluster for LONRF3 Gene Hs.144266

genes like me logo Genes that share expressions with LONRF3: view

Orthologs for LONRF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LONRF3 36
  • 99.65 (n)
  • 99.34 (a)
LONRF3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LONRF3 36
  • 87.42 (n)
  • 87.47 (a)
LONRF3 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LONRF3 36
  • 85.7 (n)
  • 85.83 (a)
LONRF3 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lonrf3 36
  • 83.11 (n)
  • 81.55 (a)
Lonrf3 16
Lonrf3 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LONRF3 37
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LONRF3 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lonrf3 36
  • 83.55 (n)
  • 82.71 (a)
chicken
(Gallus gallus)
Aves LONRF3 36
  • 66.87 (n)
  • 64.76 (a)
LONRF3 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LONRF3 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lonrf3 36
  • 60.71 (n)
  • 57.1 (a)
zebrafish
(Danio rerio)
Actinopterygii lonrf1 37
  • 36 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32369 37
  • 19 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6568 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 17 (a)
OneToMany
Species with no ortholog for LONRF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LONRF3 Gene

ENSEMBL:
Gene Tree for LONRF3 (if available)
TreeFam:
Gene Tree for LONRF3 (if available)

Paralogs for LONRF3 Gene

Paralogs for LONRF3 Gene

Selected SIMAP similar genes for LONRF3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LONRF3: view

Variants for LONRF3 Gene

Sequence variations from dbSNP and Humsavar for LONRF3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs729496 -- 118,974,350(-) CTTCT(C/G)AGTCT upstream-variant-2KB
rs907797 -- 118,983,549(+) GTGGT(A/G)GTTAT intron-variant
rs907798 -- 118,983,843(+) AGTTA(A/G)CAAAA intron-variant
rs1031565 -- 118,978,031(-) TAGTG(C/T)CCGGC intron-variant
rs1398869 -- 118,977,378(+) CTGGA(A/G)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LONRF3 Gene

Variant ID Type Subtype PubMed ID
esv2740424 CNV Deletion 23290073

Relevant External Links for LONRF3 Gene

HapMap Linkage Disequilibrium report
LONRF3
Locus Specific Mutation Databases (LSDB)
LONRF3

Disorders for LONRF3 Gene

No disorders were found for LONRF3 Gene.

No data available for UniProtKB/Swiss-Prot for LONRF3 Gene

Publications for LONRF3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PMID: 20195357) Miyamoto-Sato E. … Yanagawa H. (PLoS ONE 2010) 3
  5. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. (PMID: 23898208) Johnson T.P. … Nath A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for LONRF3 Gene

Sources for LONRF3 Gene

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