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Aliases for LONRF3 Gene

Aliases for LONRF3 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 3 2 3 5
  • Ring Finger Protein 127 2 3
  • RNF127 3 4
  • LON Peptidase N-Terminal Domain And RING Finger Protein 3 3
  • RING Finger Protein 127 4

External Ids for LONRF3 Gene

Previous HGNC Symbols for LONRF3 Gene

  • RNF127

Previous GeneCards Identifiers for LONRF3 Gene

  • GC0XP117891
  • GC0XP117992
  • GC0XP118108
  • GC0XP107601

Summaries for LONRF3 Gene

Entrez Gene Summary for LONRF3 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008]

GeneCards Summary for LONRF3 Gene

LONRF3 (LON Peptidase N-Terminal Domain And Ring Finger 3) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LONRF3 Gene

Genomics for LONRF3 Gene

Regulatory Elements for LONRF3 Gene

Enhancers for LONRF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF119039 1.4 FANTOM5 Ensembl ENCODE 21.7 +66.4 66361 3.1 ELF3 ATF1 THRB RARA ETV6 FOS NR2F2 SMARCA4 PBX2 IKZF1 LONRF3 KIAA1210 LOC727838
GH0XF118519 1.5 FANTOM5 Ensembl ENCODE 19.6 -448.9 -448914 13.0 TBP HDAC1 PKNOX1 ARNT ZNF133 ZBTB40 EGR1 GATA2 FOS ZBTB2 DOCK11 LONRF3 WDR44 IL13RA1 ENSG00000206862 GC0XM118570
GH0XF119014 1.5 FANTOM5 Ensembl ENCODE 19.5 +41.1 41070 2.3 HDAC1 SIN3A BMI1 GATA2 RCOR1 ETV6 FOS CEBPB JUNB ZEB2 LONRF3 LOC727838
GH0XF118723 1.4 FANTOM5 ENCODE 10.3 -247.1 -247140 7.9 PKNOX1 ARID4B SIN3A YY1 FOS KLF13 SP3 SP5 SMARCB1 KAT8 IL13RA1 LONRF3 DOCK11 ZCCHC12 ENSG00000239182
GH0XF118698 0.9 FANTOM5 Ensembl 14.2 -275.8 -275814 1.2 MAFG NFE2 EMSY SPI1 LONRF3 ENSG00000239182 IL13RA1 ZCCHC12 DOCK11 GC0XP118687 PIR32496
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LONRF3 on UCSC Golden Path with GeneCards custom track

Promoters for LONRF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000481532 1186 3601 ARID4B FEZF1 DMAP1 ZNF2 YY1 GLIS2 KLF7 SP3 YY2 SP5

Genomic Location for LONRF3 Gene

118,974,614 bp from pter
119,018,856 bp from pter
44,243 bases
Plus strand

Genomic View for LONRF3 Gene

Genes around LONRF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LONRF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LONRF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF3 Gene

Proteins for LONRF3 Gene

  • Protein details for LONRF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5JPN6
    • Q8NB00
    • Q9H647

    Protein attributes for LONRF3 Gene

    759 amino acids
    Molecular mass:
    84490 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15419.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LONRF3 Gene


neXtProt entry for LONRF3 Gene

Post-translational modifications for LONRF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LONRF3 Gene

Domains & Families for LONRF3 Gene

Gene Families for LONRF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Lon N-terminal domain.
  • Contains 2 RING-type zinc fingers.
  • Contains 1 Lon N-terminal domain.
  • Contains 2 RING-type zinc fingers.
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with LONRF3: view

Function for LONRF3 Gene

Gene Ontology (GO) - Molecular Function for LONRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LONRF3: view
genes like me logo Genes that share phenotypes with LONRF3: view

Animal Models for LONRF3 Gene

MGI Knock Outs for LONRF3:

Animal Model Products

miRNA for LONRF3 Gene

miRTarBase miRNAs that target LONRF3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LONRF3 Gene

Localization for LONRF3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LONRF3 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LONRF3 Gene

Pathways & Interactions for LONRF3 Gene

SuperPathways for LONRF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LONRF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with LONRF3: view

No data available for Pathways by source and SIGNOR curated interactions for LONRF3 Gene

Transcripts for LONRF3 Gene

Unigene Clusters for LONRF3 Gene

LON peptidase N-terminal domain and ring finger 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2: - -
SP3: - - -
SP4: - - - -

Relevant External Links for LONRF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LONRF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LONRF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LONRF3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for LONRF3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.0) and Fetal Brain (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LONRF3 Gene

Protein tissue co-expression partners for LONRF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of LONRF3 Gene:


SOURCE GeneReport for Unigene cluster for LONRF3 Gene:

genes like me logo Genes that share expression patterns with LONRF3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LONRF3 Gene

Orthologs for LONRF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LONRF3 34 35
  • 99.65 (n)
(Bos Taurus)
Mammalia LONRF3 34 35
  • 87.42 (n)
(Canis familiaris)
Mammalia LONRF3 34 35
  • 85.7 (n)
(Rattus norvegicus)
Mammalia Lonrf3 34
  • 83.55 (n)
(Mus musculus)
Mammalia Lonrf3 34 16 35
  • 83.11 (n)
(Ornithorhynchus anatinus)
Mammalia LONRF3 35
  • 62 (a)
(Monodelphis domestica)
Mammalia LONRF3 35
  • 56 (a)
(Gallus gallus)
Aves LONRF3 34 35
  • 66.87 (n)
(Anolis carolinensis)
Reptilia LONRF3 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lonrf3 34
  • 60.71 (n)
(Danio rerio)
Actinopterygii lonrf1 35
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32369 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6568 34
Species where no ortholog for LONRF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LONRF3 Gene

Gene Tree for LONRF3 (if available)
Gene Tree for LONRF3 (if available)

Paralogs for LONRF3 Gene

Paralogs for LONRF3 Gene

(4) SIMAP similar genes for LONRF3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LONRF3: view

Variants for LONRF3 Gene

Sequence variations from dbSNP and Humsavar for LONRF3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs61730253 A breast cancer sample 118,975,145(+) GCTGG(C/G)GCCGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs10127384 -- 119,006,562(+) cgctc(A/G)gctaa intron-variant
rs1031565 -- 118,978,031(-) TAGTG(C/T)CCGGC intron-variant
rs10449105 -- 119,023,140(+) GTGAA(C/T)TGATT downstream-variant-500B
rs10465423 -- 118,989,127(+) TTTTT(A/G)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LONRF3 Gene

Variant ID Type Subtype PubMed ID
esv2740424 CNV deletion 23290073

Variation tolerance for LONRF3 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LONRF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LONRF3 Gene

Disorders for LONRF3 Gene

Relevant External Links for LONRF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LONRF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LONRF3 Gene

Publications for LONRF3 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for LONRF3 Gene

Sources for LONRF3 Gene

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