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Aliases for LONRF2 Gene

Aliases for LONRF2 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 2 2 3 5
  • Neuroblastoma Apoptosis-Related Protease 3 4
  • RING Finger Protein 192 3 4
  • RNF192 3 4
  • LON Peptidase N-Terminal Domain And RING Finger Protein 2 3

External Ids for LONRF2 Gene

Previous GeneCards Identifiers for LONRF2 Gene

  • GC02M100359
  • GC02M100889
  • GC02M094654

Summaries for LONRF2 Gene

GeneCards Summary for LONRF2 Gene

LONRF2 (LON Peptidase N-Terminal Domain And Ring Finger 2) is a Protein Coding gene. Diseases associated with LONRF2 include Rectum Adenocarcinoma. GO annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF3.

Additional gene information for LONRF2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LONRF2 Gene

Genomics for LONRF2 Gene

Regulatory Elements for LONRF2 Gene

Enhancers for LONRF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H100287 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.8 +31.6 31619 7.1 HDGF PKNOX1 ARNT SIN3A ZNF766 CBX5 FOS REST SMARCB1 ZNF592 LONRF2 REV1 ENSG00000273306 CHST10 LINC01104
GH02H100283 1.3 Ensembl ENCODE dbSUPER 19.3 +37.7 37665 4.1 FOXA2 RAD21 YY1 TCF12 FOS ZBTB11 CEBPB ZEB2 REST ZNF592 LONRF2 LINC01104
GH02H100320 1.3 FANTOM5 ENCODE 15.3 +1.1 1103 2.7 RB1 SIN3A BMI1 ZNF2 GLIS2 EGR1 SCRT2 EGR2 CEBPB ZNF843 LONRF2 CHST10 LINC01104
GH02H100262 1.1 Ensembl ENCODE 16 +59.8 59820 0.4 CTCF RB1 ARNT ZNF133 RAD21 RFX5 TEAD3 CC2D1A MTA3 GATA3 LONRF2 LINC01104
GH02H100281 0.9 ENCODE dbSUPER 18.5 +40.8 40780 1.1 L3MBTL2 DPF2 ZFHX2 NFIC CTBP1 HDAC2 EGR1 SMARCA4 IKZF1 SCRT2 LONRF2 LINC01104
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LONRF2 on UCSC Golden Path with GeneCards custom track

Promoters for LONRF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000120672 733 801 RB1 SIN3A BMI1 GLIS2 EGR1 SCRT2 EGR2 ZNF843 MTA1 ZBTB26

Genomic Locations for LONRF2 Gene

Genomic Locations for LONRF2 Gene
49,443 bases
Minus strand

Genomic View for LONRF2 Gene

Genes around LONRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LONRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LONRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF2 Gene

Proteins for LONRF2 Gene

  • Protein details for LONRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 2
    Protein Accession:
    Secondary Accessions:
    • B9A006
    • Q6ZSR4

    Protein attributes for LONRF2 Gene

    754 amino acids
    Molecular mass:
    83654 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LONRF2 Gene


neXtProt entry for LONRF2 Gene

Post-translational modifications for LONRF2 Gene

  • Ubiquitination at posLast=489489
  • Modification sites at PhosphoSitePlus

Other Protein References for LONRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LONRF2 Gene

Domains & Families for LONRF2 Gene

Gene Families for LONRF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for LONRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LONRF2: view

No data available for UniProtKB/Swiss-Prot for LONRF2 Gene

Function for LONRF2 Gene

Phenotypes From GWAS Catalog for LONRF2 Gene

Gene Ontology (GO) - Molecular Function for LONRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with LONRF2: view

Phenotypes for LONRF2 Gene

GenomeRNAi human phenotypes for LONRF2:
genes like me logo Genes that share phenotypes with LONRF2: view

miRNA for LONRF2 Gene

miRTarBase miRNAs that target LONRF2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LONRF2 Gene

Localization for LONRF2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LONRF2 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LONRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with LONRF2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LONRF2 Gene

Pathways & Interactions for LONRF2 Gene

SuperPathways for LONRF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LONRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with LONRF2: view

No data available for Pathways by source and SIGNOR curated interactions for LONRF2 Gene

Drugs & Compounds for LONRF2 Gene

No Compound Related Data Available

Transcripts for LONRF2 Gene

mRNA/cDNA for LONRF2 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LONRF2 Gene

LON peptidase N-terminal domain and ring finger 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF2 Gene

No ASD Table

Relevant External Links for LONRF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LONRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LONRF2 Gene

mRNA differential expression in normal tissues according to GTEx for LONRF2 Gene

This gene is overexpressed in Fallopian Tube (x4.6).

Protein differential expression in normal tissues from HIPED for LONRF2 Gene

This gene is overexpressed in Islet of Langerhans (26.4), Heart (16.0), Platelet (10.9), and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LONRF2 Gene

Protein tissue co-expression partners for LONRF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LONRF2 Gene:


SOURCE GeneReport for Unigene cluster for LONRF2 Gene:


Evidence on tissue expression from TISSUES for LONRF2 Gene

  • Nervous system(4.8)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with LONRF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LONRF2 Gene

Orthologs for LONRF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LONRF2 34 33
  • 99.41 (n)
(Canis familiaris)
Mammalia LONRF2 33 34
  • 85.32 (n)
(Rattus norvegicus)
Mammalia Lonrf2 33
  • 80.19 (n)
(Mus musculus)
Mammalia Lonrf2 33 16 34
  • 79.41 (n)
(Bos Taurus)
Mammalia LONRF2 34 33
  • 79.37 (n)
(Ornithorhynchus anatinus)
Mammalia LONRF2 34
  • 57 (a)
(Monodelphis domestica)
Mammalia LONRF2 34
  • 56 (a)
(Gallus gallus)
Aves LONRF2 33 34
  • 69.49 (n)
(Anolis carolinensis)
Reptilia LONRF2 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lonrf2 33
  • 59.36 (n)
(Danio rerio)
Actinopterygii si:ch1073-440b2.1 33
  • 58.28 (n)
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32369 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
Species where no ortholog for LONRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LONRF2 Gene

Gene Tree for LONRF2 (if available)
Gene Tree for LONRF2 (if available)

Paralogs for LONRF2 Gene

Paralogs for LONRF2 Gene

(3) SIMAP similar genes for LONRF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LONRF2: view

Variants for LONRF2 Gene

Sequence variations from dbSNP and Humsavar for LONRF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs773205136 A colorectal cancer sample 100,294,302(+) AAGCC(A/G)ATAGC reference, missense
rs1000062968 -- 100,273,765(+) AAACA(C/G)AAAAA utr-variant-3-prime
rs1000112383 -- 100,314,897(+) AGTAA(A/G)TATTG intron-variant
rs1000147394 -- 100,303,962(+) CATAT(C/T)GTCCC intron-variant
rs1000246426 -- 100,290,553(+) GCAAG(A/G)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LONRF2 Gene

Variant ID Type Subtype PubMed ID
nsv953495 CNV deletion 24416366
nsv834311 CNV gain+loss 17160897
nsv582531 CNV gain 21841781
nsv1136389 CNV deletion 24896259
nsv1123362 CNV deletion 24896259
nsv1072959 CNV deletion 25765185
esv7741 CNV gain 19470904
esv3591752 CNV loss 21293372
esv3591751 CNV loss 21293372
esv3583986 CNV loss 25503493
esv2720436 CNV deletion 23290073
esv2675961 CNV deletion 23128226
esv2053654 CNV deletion 18987734
dgv609e201 CNV deletion 23290073
dgv1157e212 CNV loss 25503493

Variation tolerance for LONRF2 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.09; 92.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LONRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LONRF2 Gene

Disorders for LONRF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LONRF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rectum adenocarcinoma
  • adenocarcinoma of rectum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LONRF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LONRF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LONRF2 Gene

Publications for LONRF2 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for LONRF2 Gene

Sources for LONRF2 Gene

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