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Aliases for LONRF2 Gene

Aliases for LONRF2 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 2 2 3 5
  • Neuroblastoma Apoptosis-Related Protease 3 4
  • RING Finger Protein 192 3 4
  • RNF192 3 4
  • LON Peptidase N-Terminal Domain And RING Finger Protein 2 3

External Ids for LONRF2 Gene

Previous GeneCards Identifiers for LONRF2 Gene

  • GC02M100359
  • GC02M100889
  • GC02M094654

Summaries for LONRF2 Gene

GeneCards Summary for LONRF2 Gene

LONRF2 (LON Peptidase N-Terminal Domain And Ring Finger 2) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LONRF2 Gene

Genomics for LONRF2 Gene

Regulatory Elements for LONRF2 Gene

Enhancers for LONRF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F100287 1.7 FANTOM5 Ensembl ENCODE 21.7 +31.6 31619 7.1 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 FOS ZNF263 JUNB ZHX2 LONRF2 REV1 CHST10 LINC01104
GH02F100283 1.3 Ensembl ENCODE 19.3 +37.7 37665 4.1 SIN3A FEZF1 YY1 SLC30A9 GLIS2 FOS SP3 TSHZ1 MAFF SMARCA4 LONRF2 LINC01104
GH02F100320 1.3 FANTOM5 ENCODE 15.3 +1.1 1103 2.7 SIN3A ZNF2 GLIS2 SCRT2 EGR2 CEBPB ZNF843 TFDP1 ZFP69B ZNF341 LONRF2 CHST10 LINC01104
GH02F100262 1 Ensembl ENCODE 16 +59.8 59816 0.7 CTCF SUZ12 WRNIP1 ZNF133 RAD21 RFX5 TEAD3 GATA3 ZNF366 ZNF143 LONRF2 LINC01104
GH02F100411 0.6 ENCODE 18.8 -89.9 -89887 2.4 PAF1 JUND SMARCA4 POLR2A SCRT2 MAFK LONRF2 CHST10 ENSG00000270699
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LONRF2 on UCSC Golden Path with GeneCards custom track

Promoters for LONRF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000123296 933 1601 RAD21 ZNF2 GLIS2 SCRT2 EGR2 ZNF843 ZFP69B ZNF341 GLIS1 MYC

Genomic Location for LONRF2 Gene

100,273,291 bp from pter
100,322,733 bp from pter
49,443 bases
Minus strand

Genomic View for LONRF2 Gene

Genes around LONRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LONRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LONRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF2 Gene

Proteins for LONRF2 Gene

  • Protein details for LONRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 2
    Protein Accession:
    Secondary Accessions:
    • B9A006
    • Q6ZSR4

    Protein attributes for LONRF2 Gene

    754 amino acids
    Molecular mass:
    83654 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LONRF2 Gene


neXtProt entry for LONRF2 Gene

Post-translational modifications for LONRF2 Gene

  • Ubiquitination at Lys 489
  • Modification sites at PhosphoSitePlus

Other Protein References for LONRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LONRF2 Gene

Domains & Families for LONRF2 Gene

Gene Families for LONRF2 Gene

Suggested Antigen Peptide Sequences for LONRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Lon N-terminal domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 Lon N-terminal domain.
  • Contains 1 RING-type zinc finger.
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with LONRF2: view

Function for LONRF2 Gene

Gene Ontology (GO) - Molecular Function for LONRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LONRF2: view

Phenotypes for LONRF2 Gene

GenomeRNAi human phenotypes for LONRF2:
genes like me logo Genes that share phenotypes with LONRF2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LONRF2

miRNA for LONRF2 Gene

miRTarBase miRNAs that target LONRF2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LONRF2 Gene

Localization for LONRF2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LONRF2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LONRF2 Gene

Pathways & Interactions for LONRF2 Gene

SuperPathways for LONRF2 Gene

No Data Available

Interacting Proteins for LONRF2 Gene

Gene Ontology (GO) - Biological Process for LONRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with LONRF2: view

No data available for Pathways by source and SIGNOR curated interactions for LONRF2 Gene

Transcripts for LONRF2 Gene

mRNA/cDNA for LONRF2 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LONRF2 Gene

LON peptidase N-terminal domain and ring finger 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF2 Gene

No ASD Table

Relevant External Links for LONRF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LONRF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LONRF2 Gene

mRNA differential expression in normal tissues according to GTEx for LONRF2 Gene

This gene is overexpressed in Fallopian Tube (x4.6).

Protein differential expression in normal tissues from HIPED for LONRF2 Gene

This gene is overexpressed in Islet of Langerhans (26.4), Heart (16.0), Platelet (10.9), and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LONRF2 Gene

Protein tissue co-expression partners for LONRF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of LONRF2 Gene:


SOURCE GeneReport for Unigene cluster for LONRF2 Gene:

genes like me logo Genes that share expression patterns with LONRF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LONRF2 Gene

Orthologs for LONRF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LONRF2 34 35
  • 99.41 (n)
(Canis familiaris)
Mammalia LONRF2 34 35
  • 85.32 (n)
(Rattus norvegicus)
Mammalia Lonrf2 34
  • 80.19 (n)
(Mus musculus)
Mammalia Lonrf2 34 16 35
  • 79.41 (n)
(Bos Taurus)
Mammalia LONRF2 34 35
  • 79.37 (n)
(Ornithorhynchus anatinus)
Mammalia LONRF2 35
  • 57 (a)
(Monodelphis domestica)
Mammalia LONRF2 35
  • 56 (a)
(Gallus gallus)
Aves LONRF2 34 35
  • 69.49 (n)
(Anolis carolinensis)
Reptilia LONRF2 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lonrf2 34
  • 59.36 (n)
(Danio rerio)
Actinopterygii si:ch1073-440b2.1 34
  • 58.28 (n)
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32369 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
Species where no ortholog for LONRF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LONRF2 Gene

Gene Tree for LONRF2 (if available)
Gene Tree for LONRF2 (if available)

Paralogs for LONRF2 Gene

Paralogs for LONRF2 Gene

(3) SIMAP similar genes for LONRF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LONRF2: view

Variants for LONRF2 Gene

Sequence variations from dbSNP and Humsavar for LONRF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs773205136 A colorectal cancer sample 100,294,302(+) AAGCC(A/G)ATAGC reference, missense
rs10048665 -- 100,316,623(+) aggcc(A/G)actcc intron-variant
rs10166685 -- 100,306,196(+) ggtgt(A/C/G)agcca intron-variant
rs10169580 -- 100,306,653(+) AAAGG(A/G)CAGTT intron-variant
rs10170109 -- 100,307,179(+) CCTCC(C/G)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LONRF2 Gene

Variant ID Type Subtype PubMed ID
dgv1157e212 CNV loss 25503493
dgv609e201 CNV deletion 23290073
esv2053654 CNV deletion 18987734
esv2675961 CNV deletion 23128226
esv2720436 CNV deletion 23290073
esv3583986 CNV loss 25503493
esv3591751 CNV loss 21293372
esv3591752 CNV loss 21293372
esv7741 CNV gain 19470904
nsv1072959 CNV deletion 25765185
nsv1123362 CNV deletion 24896259
nsv1136389 CNV deletion 24896259
nsv582531 CNV gain 21841781
nsv834311 CNV gain+loss 17160897
nsv953495 CNV deletion 24416366

Variation tolerance for LONRF2 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.09; 92.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LONRF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LONRF2 Gene

Disorders for LONRF2 Gene

Relevant External Links for LONRF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LONRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LONRF2 Gene

Publications for LONRF2 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3 64

Products for LONRF2 Gene

Sources for LONRF2 Gene

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