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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LONRF2 Gene

protein-coding   GIFtS: 46
GCID: GC02M100889

LON Peptidase N-Terminal Domain And Ring Finger 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LON Peptidase N-Terminal Domain And Ring Finger 21 2
Neuroblastoma Apoptosis-Related Protease2 3
RNF1922 3
RING Finger Protein 1922 3
LON Peptidase N-Terminal Domain And RING Finger Protein 22

External Ids:    HGNC: 247881   Entrez Gene: 1648322   Ensembl: ENSG000001705007   UniProtKB: Q1L5Z93   

Export aliases for LONRF2 gene to outside databases

Previous GC identifers: GC02M100359 GC02M100256 GC02M094654


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LONRF2 Gene: 
LONRF2 (LON peptidase N-terminal domain and ring finger 2) is a protein-coding gene. Diseases associated with LONRF2 include neuroblastoma. GO annotations related to this gene include ATP-dependent peptidase activity and zinc ion binding. An important paralog of this gene is LONRF3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LONRF2 gene promoter:
         AhR   p53   Pax-5   NF-E2 p45   FOXL1   AREB6   PPAR-gamma1   PPAR-gamma2   NF-E2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLONRF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for LONRF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LONRF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

LONRF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LONRF2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M100889:  view genomic region     (about GC identifiers)

Start:
100,889,753 bp from pter      End:
100,939,195 bp from pter
Size:
49,443 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LONF2_HUMAN, Q1L5Z9 (See protein sequence)
Recommended Name: LON peptidase N-terminal domain and RING finger protein 2  
Size: 754 amino acids; 83654 Da
Secondary accessions: B9A006 Q6ZSR4
Alternative splicing: 2 isoforms:  Q1L5Z9-1   Q1L5Z9-2   

Explore the universe of human proteins at neXtProt for LONRF2: NX_Q1L5Z9

Explore proteomics data for LONRF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q1L5Z9

  • LONRF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LONRF2 Protein Expression
    REFSEQ proteins: NP_940863.3  
    ENSEMBL proteins: 
     ENSP00000377086   ENSP00000386823  

    Human Recombinant Protein Products for LONRF2: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/8 InterPro protein domains (see all 8):
     IPR015947 PUA-like_domain
     IPR017907 Znf_RING_CS
     IPR011990 TPR-like_helical
     IPR001841 Znf_RING
     IPR003111 Pept_S16_N

    Graphical View of Domain Structure for InterPro Entry Q1L5Z9

    ProtoNet protein and cluster: Q1L5Z9

    UniProtKB/Swiss-Prot: LONF2_HUMAN, Q1L5Z9
    Similarity: Contains 1 Lon domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 6 TPR repeats


    LONRF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004176ATP-dependent peptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    LONRF2 for ontologies           About GeneDecksing


    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LONRF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LONRF2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/16 Interacting proteins for LONRF2 (Q1L5Z93 ENSP000003770864) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OTUD5Q96G743, ENSP000001560844I2D: score=2 STRING: ENSP00000156084
    DTX4Q9Y2E63I2D: score=5 
    NUP88Q995673I2D: score=5 
    RPL4P365783I2D: score=5 
    RPS13P622773I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    LONRF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LONRF2 (LONF2)

    Search CenterWatch for drugs/clinical trials and news about LONRF2 / LONF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LONRF2 gene: 
    NM_198461.3  

    Unigene Cluster for LONRF2:

    LON peptidase N-terminal domain and ring finger 2
    Hs.21380  [show with all ESTs]
    Unigene Representative Sequence: NM_198461
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393437(uc010yvs.2 uc002tal.4) ENST00000409647
    miRNA
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    8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate LONRF2 (see all 64):
    hsa-miR-520e hsa-miR-200a hsa-miR-489 hsa-miR-3148 hsa-miR-520b hsa-miR-3688-3p hsa-miR-130a* hsa-miR-27a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LONRF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LONRF2

    Additional mRNA sequence: 

    AK056373.1 AK094044.1 AK123836.1 AK124739.1 AK127206.1 AK128715.1 AL157505.1 BC101662.1 
    BC101664.1 BC143468.1 BC143471.1 DQ020495.1 

    4 DOTS entries:

    DT.101980327  DT.414342  DT.95250647  DT.95375042 

    13 AceView cDNA sequences:

    AA399472 BU608207 BM835642 NM_198461 BQ222673 BU101605 BM713232 AK127206 
    H06779 AA293401 BQ719190 H06730 H08893 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LONRF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCTTGTA
    LONRF2 Expression
    About this image


    See LONRF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LONRF2

    SOURCE GeneReport for Unigene cluster: Hs.21380
        SABiosciences Custom PCR Arrays for LONRF2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LONRF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LONRF2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lonrf21 , 5 LON peptidase N-terminal domain and ring finger 21, 5 79(n)1
    79.84(a)1
      1 (17.17 cM)5
    3813381  NM_001029878.11  NP_001025049.11 
     387936695 
    chicken
    (Gallus gallus)
    Aves LONRF21 LON peptidase N-terminal domain and ring finger 2 67.95(n)
    61.02(a)
      418706  XM_416903.3  XP_416903.3 
    lizard
    (Anolis carolinensis)
    Reptilia LONRF26
    LON peptidase N-terminal domain and ring finger 2
    50(a)
    1 ↔ 1
    GL343456.1(570668-614234)
    zebrafish
    (Danio rerio)
    Actinopterygii LONRF26
    LON peptidase N-terminal domain and ring finger 2
    50(a)
    1 ↔ 1
    1(27451830-27533686)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG323696
    --
    19(a)
    1 → many
    3L(7770318-7802925)


    ENSEMBL Gene Tree for LONRF2 (if available)
    TreeFam Gene Tree for LONRF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LONRF2 gene
    LONRF32  LONRF12  
    4 SIMAP similar genes for LONRF2 using alignment to 3 protein entries:     LONF2_HUMAN (see all proteins):
    LONRF1    LONRF3    BRCA1    TRIM39

    LONRF2 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for LONRF2
    PGOHUM00000248498 PGOHUM00000246624 PGOHUM00000246636 PGOHUM00000234878 PGOHUM00000239132


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1155 SNPs in LONRF2 are shown (see all 1155)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359534
    A colorectal cancer sample4--see VAR_0359532 R W mis40--------
    rs1494441651,2
    C--100889369(+) GAATCA/GTTCCA 1 -- int10--------
    rs48512821,2
    C,F,A,H--100889386(+) CACTGT/CGTTGA 1 -- int122Minor allele frequency- C:0.19NS EA WA NA CSA 2349
    rs1118264301,2
    C--100889402(+) GTTCCC/TCTAAA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1837984501,2
    --100889505(+) GGGTGA/GAAGTT 1 -- int10--------
    rs1134460791,2
    C,F--100889617(+) TGCAGC/TCGCTG 1 -- int12Minor allele frequency- T:0.04CSA WA 119
    rs1884337581,2
    --100889619(+) CAGCCA/GCTGGC 1 -- int10--------
    rs1448356011,2
    --100889707(+) AAGCCC/TGGCCC 1 -- int10--------
    rs1156807521,2
    C,F--100889774(+) ATTTAT/CTGTGA 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1930521271,2
    C--100889787(+) AGCCGA/TCAGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LONRF2 (100889753 - 100939195 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LONRF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675961CNV Deletion23128226
    esv2720436CNV Deletion23290073
    dgv652e201CNV Deletion23290073
    esv2053654CNV Deletion18987734
    nsv834311CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for LONRF2:    About MalaCards
    neuroblastoma    


    LONRF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LONRF2
    Human Genome Epidemiology (HuGE) Navigator: LONRF2 (1 document)

    Export disorders for LONRF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LONRF2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with LONRF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 164832 HGNC: 24788 AceView: FLJ45273 Ensembl:ENSG00000170500 euGenes: HUgn164832
    ECgene: LONRF2 H-InvDB: LONRF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LONRF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LONRF2 gene:
    Search GeneIP for patents involving LONRF2

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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