Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LONRF2 Gene

Aliases for LONRF2 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 2 2 3 5
  • Neuroblastoma Apoptosis-Related Protease 3 4
  • RING Finger Protein 192 3 4
  • RNF192 3 4

External Ids for LONRF2 Gene

Previous GeneCards Identifiers for LONRF2 Gene

  • GC02M100359
  • GC02M100889
  • GC02M094654

Summaries for LONRF2 Gene

GeneCards Summary for LONRF2 Gene

LONRF2 (LON Peptidase N-Terminal Domain And Ring Finger 2) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LONRF2 Gene

Genomics for LONRF2 Gene

Regulatory Elements for LONRF2 Gene

Enhancers for LONRF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LONRF2 on UCSC Golden Path with GeneCards custom track

Promoters for LONRF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LONRF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LONRF2 Gene

100,273,291 bp from pter
100,322,733 bp from pter
49,443 bases
Minus strand

Genomic View for LONRF2 Gene

Genes around LONRF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LONRF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LONRF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF2 Gene

Proteins for LONRF2 Gene

  • Protein details for LONRF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 2
    Protein Accession:
    Secondary Accessions:
    • B9A006
    • Q6ZSR4

    Protein attributes for LONRF2 Gene

    754 amino acids
    Molecular mass:
    83654 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LONRF2 Gene


neXtProt entry for LONRF2 Gene

Proteomics data for LONRF2 Gene at MOPED

Post-translational modifications for LONRF2 Gene

  • Ubiquitination at Lys 489
  • Modification sites at PhosphoSitePlus

Other Protein References for LONRF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LONRF2 Gene

Domains & Families for LONRF2 Gene

Gene Families for LONRF2 Gene

Suggested Antigen Peptide Sequences for LONRF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Lon N-terminal domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 Lon N-terminal domain.
  • Contains 1 RING-type zinc finger.
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with LONRF2: view

Function for LONRF2 Gene

Gene Ontology (GO) - Molecular Function for LONRF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with LONRF2: view

Phenotypes for LONRF2 Gene

GenomeRNAi human phenotypes for LONRF2:
genes like me logo Genes that share phenotypes with LONRF2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LONRF2

miRNA for LONRF2 Gene

miRTarBase miRNAs that target LONRF2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LONRF2 Gene

Localization for LONRF2 Gene

Subcellular locations from

Jensen Localization Image for LONRF2 Gene COMPARTMENTS Subcellular localization image for LONRF2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LONRF2 Gene

Pathways & Interactions for LONRF2 Gene

SuperPathways for LONRF2 Gene

No Data Available

Interacting Proteins for LONRF2 Gene

Gene Ontology (GO) - Biological Process for LONRF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for LONRF2 Gene

Drugs & Compounds for LONRF2 Gene

No Compound Related Data Available

Transcripts for LONRF2 Gene

mRNA/cDNA for LONRF2 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LONRF2 Gene

LON peptidase N-terminal domain and ring finger 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF2 Gene

No ASD Table

Relevant External Links for LONRF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LONRF2 Gene

mRNA expression in normal human tissues for LONRF2 Gene

mRNA differential expression in normal tissues according to GTEx for LONRF2 Gene

This gene is overexpressed in Fallopian Tube (x4.6).

Protein differential expression in normal tissues from HIPED for LONRF2 Gene

This gene is overexpressed in Islet of Langerhans (26.4), Heart (16.0), Platelet (10.9), and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LONRF2 Gene

SOURCE GeneReport for Unigene cluster for LONRF2 Gene Hs.21380

genes like me logo Genes that share expression patterns with LONRF2: view

Protein tissue co-expression partners for LONRF2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LONRF2 Gene

Orthologs for LONRF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LONRF2 35
  • 79.37 (n)
  • 73.88 (a)
  • 55 (a)
(Canis familiaris)
Mammalia LONRF2 35
  • 85.32 (n)
  • 85.23 (a)
  • 74 (a)
(Mus musculus)
Mammalia Lonrf2 35
  • 79.41 (n)
  • 80.2 (a)
Lonrf2 16
Lonrf2 36
  • 78 (a)
(Pan troglodytes)
Mammalia LONRF2 35
  • 99.41 (n)
  • 99.61 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Lonrf2 35
  • 80.19 (n)
  • 80.06 (a)
(Monodelphis domestica)
Mammalia LONRF2 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia LONRF2 36
  • 57 (a)
(Gallus gallus)
Aves LONRF2 35
  • 69.49 (n)
  • 63.19 (a)
  • 49 (a)
(Anolis carolinensis)
Reptilia LONRF2 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lonrf2 35
  • 59.36 (n)
  • 53.89 (a)
(Danio rerio)
Actinopterygii si:ch1073-440b2.1 35
  • 58.28 (n)
  • 54.3 (a)
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32369 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
Species with no ortholog for LONRF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LONRF2 Gene

Gene Tree for LONRF2 (if available)
Gene Tree for LONRF2 (if available)

Paralogs for LONRF2 Gene

Paralogs for LONRF2 Gene

(3) SIMAP similar genes for LONRF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LONRF2: view

Variants for LONRF2 Gene

Sequence variations from dbSNP and Humsavar for LONRF2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs4851287 -, - 100,299,310(+) TTTGA(A/G)GTGAG reference, missense
VAR_035953 A colorectal cancer sample
rs764828 -- 100,292,172(-) GCGCC(G/T)CCAGT intron-variant
rs764829 -- 100,292,046(-) GGGGA(C/T)GTGTA intron-variant
rs1866198 -- 100,301,277(-) CCAAT(G/T)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LONRF2 Gene

Variant ID Type Subtype PubMed ID
nsv834311 CNV Gain+Loss 17160897
esv2675961 CNV Deletion 23128226
esv2053654 CNV Deletion 18987734
dgv652e201 CNV Deletion 23290073
esv2720436 CNV Deletion 23290073

Variation tolerance for LONRF2 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.09; 92.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LONRF2 Gene

Disorders for LONRF2 Gene

Relevant External Links for LONRF2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LONRF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LONRF2 Gene

Publications for LONRF2 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for LONRF2 Gene

Sources for LONRF2 Gene