Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LONRF1 Gene

Aliases for LONRF1 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 1 2 3
  • RING Finger Protein 191 3 4
  • RNF191 3 4
  • LON Peptidase N-Terminal Domain And RING Finger Protein 1 3

External Ids for LONRF1 Gene

Summaries for LONRF1 Gene

GeneCards Summary for LONRF1 Gene

LONRF1 (LON Peptidase N-Terminal Domain And Ring Finger 1) is a Protein Coding gene. GO annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LONRF1 Gene

Genomics for LONRF1 Gene

Genomic Location for LONRF1 Gene

Start:
12,721,894 bp from pter
End:
12,756,073 bp from pter
Size:
34,180 bases
Orientation:
Minus strand

Genomic View for LONRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LONRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF1 Gene

Regulatory Elements for LONRF1 Gene

Proteins for LONRF1 Gene

  • Protein details for LONRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RB8-LONF1_HUMAN
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 1
    Protein Accession:
    Q17RB8
    Secondary Accessions:
    • B4DM29
    • B4DU84
    • Q8TEA0
    • Q9BSV1

    Protein attributes for LONRF1 Gene

    Size:
    773 amino acids
    Molecular mass:
    86725 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17382.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI17386.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85052.1; Type=Frameshift; Positions=463; Evidence={ECO:0000305}; Sequence=BAG59741.1; Type=Frameshift; Positions=293; Evidence={ECO:0000305}; Sequence=BAG62246.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LONRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LONRF1 Gene

Proteomics data for LONRF1 Gene at MOPED

Post-translational modifications for LONRF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LONRF1 Gene

No data available for DME Specific Peptides for LONRF1 Gene

Domains for LONRF1 Gene

Gene Families for LONRF1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Suggested Antigen Peptide Sequences for LONRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17RB8

UniProtKB/Swiss-Prot:

LONF1_HUMAN
Domain:
  • Contains 1 Lon domain.:
    • Q17RB8
Similarity:
  • Contains 2 RING-type zinc fingers.:
    • Q17RB8
  • Contains 4 TPR repeats.:
    • Q17RB8
genes like me logo Genes that share domains with LONRF1: view

Function for LONRF1 Gene

Gene Ontology (GO) - Molecular Function for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004176 ATP-dependent peptidase activity IEA --
GO:0005515 protein binding IPI 19549727
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with LONRF1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LONRF1 Gene

Localization for LONRF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LONRF1 Gene COMPARTMENTS Subcellular localization image for LONRF1 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LONRF1 Gene

Pathways for LONRF1 Gene

SuperPathways for LONRF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with LONRF1: view

No data available for Pathways by source for LONRF1 Gene

Transcripts for LONRF1 Gene

Unigene Clusters for LONRF1 Gene

LON peptidase N-terminal domain and ring finger 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: -
SP3:

Relevant External Links for LONRF1 Gene

GeneLoc Exon Structure for
LONRF1
ECgene alternative splicing isoforms for
LONRF1

Expression for LONRF1 Gene

mRNA expression in normal human tissues for LONRF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LONRF1 Gene

SOURCE GeneReport for Unigene cluster for LONRF1 Gene Hs.180178

genes like me logo Genes that share expressions with LONRF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LONRF1 Gene

Orthologs for LONRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LONRF1 35
  • 99.48 (n)
  • 99.61 (a)
LONRF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LONRF1 35
  • 91.59 (n)
  • 92.16 (a)
LONRF1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LONRF1 35
  • 92.85 (n)
  • 92.13 (a)
LONRF1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lonrf1 35
  • 84.82 (n)
  • 88.19 (a)
Lonrf1 16
Lonrf1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LONRF1 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lonrf1 35
  • 85.6 (n)
  • 89.37 (a)
chicken
(Gallus gallus)
Aves LONRF1 35
  • 75.12 (n)
  • 73.44 (a)
LONRF1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LONRF1 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1931 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lonrf1 35
  • 63.26 (n)
  • 60.82 (a)
zebrafish
(Danio rerio)
Actinopterygii lonrf1l 35
  • 55.14 (n)
  • 53.56 (a)
lonrf1l 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32369 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4463 36
  • 38 (a)
ManyToMany
Species with no ortholog for LONRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LONRF1 Gene

ENSEMBL:
Gene Tree for LONRF1 (if available)
TreeFam:
Gene Tree for LONRF1 (if available)

Paralogs for LONRF1 Gene

Paralogs for LONRF1 Gene

Selected SIMAP similar genes for LONRF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LONRF1: view

Variants for LONRF1 Gene

Sequence variations from dbSNP and Humsavar for LONRF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1018855 -- 12,721,939(+) TAAAT(A/T)AGCAA utr-variant-3-prime
rs1018856 -- 12,721,973(+) TACAA(A/G)TTACT utr-variant-3-prime
rs1139354 - 12,743,211(+) TTCTA(A/T)GGCTG reference, missense
rs3802267 -- 12,722,783(+) ACGCA(C/G)GCACA utr-variant-3-prime
rs3802269 -- 12,731,670(+) GCTTG(A/C)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LONRF1 Gene

Variant ID Type Subtype PubMed ID
dgv2199e1 CNV Complex 17122850
dgv2200e1 CNV Complex 17122850
dgv244e55 CNV Gain 17911159
dgv2204e1 CNV Complex 17122850
dgv246e55 CNV Gain 17911159
dgv2212e1 CNV Complex 17122850

Relevant External Links for LONRF1 Gene

HapMap Linkage Disequilibrium report
LONRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LONRF1 Gene

Disorders for LONRF1 Gene

Relevant External Links for LONRF1

Genetic Association Database (GAD)
LONRF1
genes like me logo Genes that share disorders with LONRF1: view

No data available for UniProtKB/Swiss-Prot for LONRF1 Gene

Publications for LONRF1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Comparative FISH-mapping of twelve loci in river buffalo and sheep chromosomes: comparison with HSA8p and HSA4q. (PMID: 18253036) Perucatti A. … Iannuzzi L. (Cytogenet. Genome Res. 2007) 2 3
  4. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3
  5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3

Products for LONRF1 Gene

Sources for LONRF1 Gene

Back to Top

Content