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Aliases for LONRF1 Gene

Aliases for LONRF1 Gene

  • LON Peptidase N-Terminal Domain And Ring Finger 1 2 3 5
  • RING Finger Protein 191 3 4
  • RNF191 3 4
  • LON Peptidase N-Terminal Domain And RING Finger Protein 1 3

External Ids for LONRF1 Gene

Previous GeneCards Identifiers for LONRF1 Gene

  • GC08M012624
  • GC08M011121
  • GC08M012579

Summaries for LONRF1 Gene

GeneCards Summary for LONRF1 Gene

LONRF1 (LON Peptidase N-Terminal Domain And Ring Finger 1) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ATP-dependent peptidase activity. An important paralog of this gene is LONRF2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LONRF1 Gene

Genomics for LONRF1 Gene

Regulatory Elements for LONRF1 Gene

Enhancers for LONRF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F012725 1.2 Ensembl ENCODE 16.6 +29.4 29397 2.5 ELF3 ZFP64 RARA ZNF366 FOS EGR2 MIXL1 ZNF362 JUNB CEBPB LONRF1 MIR3926-2 MIR5692A2
GH08F012764 1.4 FANTOM5 Ensembl ENCODE 9.4 -10.1 -10098 3.3 HDGF TBP PKNOX1 TBL1XR1 ASH2L MAX RELA ELK1 POLR2A CBX5 LONRF1 LINC00681 DLC1 GC08P012767
GH08F013120 1.6 FANTOM5 Ensembl ENCODE 5.6 -371.7 -371742 14.7 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF263 SP3 MXD4 REST RNU6-842P RPS3AP34 ENSG00000255122 DLC1 ALG1L12P LONRF1 KIAA1456 LOC100421094 GC08P013101 GC08P013155
GH08F012840 0.7 ENCODE 11.8 -84.8 -84774 0.2 CTCF MAX RAD21 RFX5 TEAD3 SCRT2 ZNF26 ZNF143 SMC3 MAFK LONRF1 RPS3AP34 ENSG00000255122 KIAA1456 GC08P012821 PIR55936
GH08F012795 0.6 FANTOM5 11.5 -39.2 -39221 0.2 ELF3 HLF CEBPA CEBPB FOXP2 CEBPG LONRF1 LINC00681 LOC340357
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LONRF1 on UCSC Golden Path with GeneCards custom track

Promoters for LONRF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001438996 1073 3201 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 KLF13 SP3 SP5 NFYC

Genomic Location for LONRF1 Gene

Chromosome:
8
Start:
12,721,894 bp from pter
End:
12,756,073 bp from pter
Size:
34,180 bases
Orientation:
Minus strand

Genomic View for LONRF1 Gene

Genes around LONRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LONRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LONRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LONRF1 Gene

Proteins for LONRF1 Gene

  • Protein details for LONRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RB8-LONF1_HUMAN
    Recommended name:
    LON peptidase N-terminal domain and RING finger protein 1
    Protein Accession:
    Q17RB8
    Secondary Accessions:
    • B4DM29
    • B4DU84
    • Q8TEA0
    • Q9BSV1

    Protein attributes for LONRF1 Gene

    Size:
    773 amino acids
    Molecular mass:
    86725 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17382.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI17386.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85052.1; Type=Frameshift; Positions=463; Evidence={ECO:0000305}; Sequence=BAG59741.1; Type=Frameshift; Positions=293; Evidence={ECO:0000305}; Sequence=BAG62246.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LONRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LONRF1 Gene

Post-translational modifications for LONRF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LONRF1 Gene

Domains & Families for LONRF1 Gene

Gene Families for LONRF1 Gene

Suggested Antigen Peptide Sequences for LONRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q17RB8

UniProtKB/Swiss-Prot:

LONF1_HUMAN :
  • Contains 1 Lon N-terminal domain.
  • Contains 2 RING-type zinc fingers.
Domain:
  • Contains 1 Lon N-terminal domain.
Similarity:
  • Contains 2 RING-type zinc fingers.
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with LONRF1: view

Function for LONRF1 Gene

Gene Ontology (GO) - Molecular Function for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004176 ATP-dependent peptidase activity IEA --
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 19549727
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LONRF1: view

Phenotypes for LONRF1 Gene

genes like me logo Genes that share phenotypes with LONRF1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LONRF1 Gene

Localization for LONRF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LONRF1 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LONRF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LONRF1 Gene

Pathways & Interactions for LONRF1 Gene

genes like me logo Genes that share pathways with LONRF1: view

Gene Ontology (GO) - Biological Process for LONRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with LONRF1: view

No data available for SIGNOR curated interactions for LONRF1 Gene

Transcripts for LONRF1 Gene

Unigene Clusters for LONRF1 Gene

LON peptidase N-terminal domain and ring finger 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LONRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: -
SP3:

Relevant External Links for LONRF1 Gene

GeneLoc Exon Structure for
LONRF1
ECgene alternative splicing isoforms for
LONRF1

Expression for LONRF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LONRF1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LONRF1 Gene



Protein tissue co-expression partners for LONRF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of LONRF1 Gene:

LONRF1

SOURCE GeneReport for Unigene cluster for LONRF1 Gene:

Hs.180178
genes like me logo Genes that share expression patterns with LONRF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LONRF1 Gene

Orthologs for LONRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LONRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LONRF1 34 35
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia LONRF1 34 35
  • 92.85 (n)
cow
(Bos Taurus)
Mammalia LONRF1 34 35
  • 91.59 (n)
rat
(Rattus norvegicus)
Mammalia Lonrf1 34
  • 85.6 (n)
mouse
(Mus musculus)
Mammalia Lonrf1 34 16 35
  • 84.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LONRF1 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves LONRF1 34 35
  • 75.12 (n)
lizard
(Anolis carolinensis)
Reptilia LONRF1 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lonrf1 34
  • 63.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1931 34
zebrafish
(Danio rerio)
Actinopterygii lonrf1l 34 35
  • 55.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32369 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4463 35
  • 38 (a)
ManyToMany
Species where no ortholog for LONRF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LONRF1 Gene

ENSEMBL:
Gene Tree for LONRF1 (if available)
TreeFam:
Gene Tree for LONRF1 (if available)

Paralogs for LONRF1 Gene

Paralogs for LONRF1 Gene

(9) SIMAP similar genes for LONRF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LONRF1: view

Variants for LONRF1 Gene

Sequence variations from dbSNP and Humsavar for LONRF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10087856 -- 12,733,015(+) aagtt(C/T)agcat intron-variant
rs10095845 -- 12,727,150(+) CTGCT(C/T)TGCAC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs10098478 -- 12,741,533(+) CACCA(A/T)GTCAG intron-variant
rs10098734 -- 12,741,762(+) CCATG(A/C)AATTT intron-variant
rs10100866 -- 12,726,145(+) AGCCC(C/T)CAAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LONRF1 Gene

Variant ID Type Subtype PubMed ID
nsv1077019 CNV deletion 25765185
nsv1029648 CNV gain 25217958
esv3616292 CNV loss 21293372
esv2759593 CNV gain+loss 17122850
dgv246e55 CNV gain 17911159
dgv244e55 CNV gain 17911159

Variation tolerance for LONRF1 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LONRF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LONRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LONRF1 Gene

Disorders for LONRF1 Gene

Relevant External Links for LONRF1

Genetic Association Database (GAD)
LONRF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LONRF1

No disorders were found for LONRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LONRF1 Gene

Publications for LONRF1 Gene

  1. Comparative FISH-mapping of twelve loci in river buffalo and sheep chromosomes: comparison with HSA8p and HSA4q. (PMID: 18253036) Perucatti A. … Iannuzzi L. (Cytogenet. Genome Res. 2007) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genome-wide diet-gene interaction analyses for risk of colorectal cancer. (PMID: 24743840) Figueiredo J.C. … . (PLoS Genet. 2014) 3 64
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64

Products for LONRF1 Gene

Sources for LONRF1 Gene

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