LOH12CR1 Gene
protein-coding GIFtS: 45
GCID: GC12P012510
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loss of heterozygosity, 12, chromosomal region 1
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Aliases
for LOH12CR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Loss Of Heterozygosity, 12, Chromosomal Region 11 2 | | LOH1CR121 2 | | Loss Of Heterozygosity 12 Chromosomal Region 1 Protein2 |
Export aliases for LOH12CR1 gene to outside databasesPrevious GC identifers: GC12P012238 GC12P012654 GC12P012410 GC12P012401 GC12P012276 |
Summaries
for LOH12CR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LOH12CR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LOH12CR1 gene promoter:
Sp1 HTF FOXD1 LCR-F1 RORalpha1 FOXJ2 (long isoform) c-Myb FOXJ2 ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for LOH12CR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LOH12CR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p12 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p12LOH12CR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P012510: view genomic region
(about GC identifiers)
Start:
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12,510,013 bp from pter |
End:
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12,619,840 bp from pter |
Size:
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109,828 bases |
Orientation:
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plus strand |
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Proteins
for LOH12CR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: L12R1_HUMAN, Q969J3 (See
protein sequence)Recommended Name: Loss of heterozygosity 12 chromosomal region 1 protein Size: 196 amino acids; 22222 Da
Secondary accessions: Q96QS5Alternative splicing: 2 isoforms: Q969J3-1 Q969J3-2 Explore the universe of human proteins at neXtProt for LOH12CR1: NX_Q969J3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969J3
LOH12CR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_477517.1
ENSEMBL proteins: ENSP00000443023 ENSP00000321546 ENSP00000298571
Human Recombinant Protein Products for LOH12CR1:
LOH12CR1 Antibody Products:
Assay Products for LOH12CR1: |
Protein
Domains /
Families
for LOH12CR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LOH12CR1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969J3ProtoNet protein and cluster: Q969J3 UniProtKB/Swiss-Prot: L12R1_HUMAN, Q969J3Similarity: Belongs to the LOH12CR1 family |
Function
for LOH12CR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LOH12CR1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LOH12CR1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LOH12CR1 (NM_058169) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LOH12CR1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOH12CR1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOH12CR1 |
|
Pathways & Interactions
for LOH12CR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LOH12CR1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/7 Interacting proteins for LOH12CR1 (Q969J32, 3 ENSP000003215464) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
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Drugs & Compounds
for LOH12CR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LOH12CR1
Search CenterWatch for drugs/clinical trials and news about LOH12CR1 / L12R1
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Transcripts
for LOH12CR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LOH12CR1 gene: NM_058169.3 Unigene Cluster for LOH12CR1: Loss of heterozygosity, 12, chromosomal region 1 Hs.720779 [show with all ESTs]Unigene Representative Sequence: NM_0581694 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000542728 ENST00000314565(uc001ral.2 uc009zhu.2) ENST00000543990
ENST00000298571
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LOH12CR1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LOH12CR1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LOH12CR1 (NM_058169) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LOH12CR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOH12CR1 |
Additional cDNA sequence: AK075028.1 AY037865.1 AY037866.1 BC013668.1 4 DOTS entries: DT.91830101 DT.309934 DT.95287987 DT.121114129 24/78 AceView cDNA sequences (see all 78): AY037865 BF346137 BQ690027 AW453026 AA256281 CR626601 AW504388 AW026232 AY037866 AA447954 BI755201 BI561226 BM828171 BE673048 BQ720087 AK075028 BC013668 BQ576126 BG760738 BX477004 BF059392 BU621326 AA459384 BU625021
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for LOH12CR1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for LOH12CR1
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Expression
for LOH12CR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LOH12CR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATCTGAC
About this image
See LOH12CR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LOH12CR1
SOURCE GeneReport for Unigene cluster: Hs.720779
UniProtKB/Swiss-Prot: L12R1_HUMAN, Q969J3Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for LOH12CR1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LOH12CR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LOH12CR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LOH12CR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LOH12CR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOH12CR1 |
Orthologs
for LOH12CR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for LOH12CR1 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for LOH12CR1 (if available)
TreeFam Gene Tree for LOH12CR1 (if available) |
Paralogs
for LOH12CR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for LOH12CR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LOH12CR1 (12510013 - 12619840 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for LOH12CR1
8 CNVs: 10389 48977 53546 10390 38249 86226 48975 48976
1 Indel: 10687
3 Inversions: 29397 103326 59705 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LOH12CR1 |
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Disorders
/ Diseases
for LOH12CR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LOH12CR1 for disorders About GeneDecksing
3  diseases for LOH12CR1: About MalaCardsacute lymphoblastic leukemia lymphoblastic leukemia leukemia
Export disorders for LOH12CR1 gene to outside databases
|
Publications
for LOH12CR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LOH12CR1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with LOH12CR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus. (PubMed id 11896457)1, 2, 3 Montpetit A.... Sinnett D. (2002)
- Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia. (PubMed id 15284860)1, 3 Montpetit A.... Sinnett D. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)1 Teixeira F.R.... Gomes M.D. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)2 Beausoleil S.A.... Gygi S.P. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
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External Searches for LOH12CR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing LOH12CR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LOH12CR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LOH12CR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for LOH12CR1 gene:
Search GeneIP for patents involving LOH12CR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LOH12CR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LOH12CR1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LOH12CR1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LOH12CR1 | | | OriGene Protein Over-expression Lysate for LOH12CR1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LOH12CR1 | | OriGene 3'-UTR Clone for LOH12CR1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LOH12CR1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LOH12CR1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LOH12CR1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LOH12CR1 | | OriGene Custom Protein Services for LOH12CR1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LOH12CR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LOH12CR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LOH12CR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LOH12CR1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LOH12CR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LOH12CR1 |
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 | | | LOH12CR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOH12CR1 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LOH12CR1 |
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