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Aliases for LOH12CR1 Gene

Aliases for LOH12CR1 Gene

  • Loss Of Heterozygosity, 12, Chromosomal Region 1 2 3
  • Loss Of Heterozygosity 12 Chromosomal Region 1 Protein 3
  • LOH1CR12 3

External Ids for LOH12CR1 Gene

Previous GeneCards Identifiers for LOH12CR1 Gene

  • GC12P012238
  • GC12P012654
  • GC12P012410
  • GC12P012401
  • GC12P012510
  • GC12P012276

Summaries for LOH12CR1 Gene

GeneCards Summary for LOH12CR1 Gene

LOH12CR1 (Loss Of Heterozygosity, 12, Chromosomal Region 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOH12CR1 Gene

Genomics for LOH12CR1 Gene

Regulatory Elements for LOH12CR1 Gene

Genomic Location for LOH12CR1 Gene

Start:
12,357,033 bp from pter
End:
12,484,653 bp from pter
Size:
127,621 bases
Orientation:
Plus strand

Genomic View for LOH12CR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LOH12CR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOH12CR1 Gene

Proteins for LOH12CR1 Gene

  • Protein details for LOH12CR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969J3-L12R1_HUMAN
    Recommended name:
    Loss of heterozygosity 12 chromosomal region 1 protein
    Protein Accession:
    Q969J3
    Secondary Accessions:
    • Q96QS5

    Protein attributes for LOH12CR1 Gene

    Size:
    196 amino acids
    Molecular mass:
    22222 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LOH12CR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LOH12CR1 Gene

Proteomics data for LOH12CR1 Gene at MOPED

Post-translational modifications for LOH12CR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LOH12CR1 Gene

Antibody Products

No data available for DME Specific Peptides for LOH12CR1 Gene

Domains for LOH12CR1 Gene

Protein Domains for LOH12CR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LOH12CR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969J3

UniProtKB/Swiss-Prot:

L12R1_HUMAN :
  • Q969J3
Family:
  • Belongs to the LOH12CR1 family.
genes like me logo Genes that share domains with LOH12CR1: view

No data available for Gene Families for LOH12CR1 Gene

Function for LOH12CR1 Gene

Gene Ontology (GO) - Molecular Function for LOH12CR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with LOH12CR1: view

Animal Model Products

CRISPR Products

miRNA for LOH12CR1 Gene

miRTarBase miRNAs that target LOH12CR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LOH12CR1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LOH12CR1 Gene

Localization for LOH12CR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LOH12CR1 Gene COMPARTMENTS Subcellular localization image for LOH12CR1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LOH12CR1 Gene

Pathways for LOH12CR1 Gene

SuperPathways for LOH12CR1 Gene

No Data Available

Interacting Proteins for LOH12CR1 Gene

Gene Ontology (GO) - Biological Process for LOH12CR1 Gene

None

No data available for Pathways by source for LOH12CR1 Gene

Transcripts for LOH12CR1 Gene

Unigene Clusters for LOH12CR1 Gene

Loss of heterozygosity, 12, chromosomal region 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LOH12CR1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LOH12CR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LOH12CR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for LOH12CR1 Gene

GeneLoc Exon Structure for
LOH12CR1
ECgene alternative splicing isoforms for
LOH12CR1

Expression for LOH12CR1 Gene

mRNA expression in normal human tissues for LOH12CR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LOH12CR1 Gene

SOURCE GeneReport for Unigene cluster for LOH12CR1 Gene Hs.720779

mRNA Expression by UniProt/SwissProt for LOH12CR1 Gene

Q969J3-L12R1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with LOH12CR1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LOH12CR1 Gene

Orthologs for LOH12CR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LOH12CR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOH12CR1 35
  • 99.49 (n)
  • 99.49 (a)
LOH12CR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOH12CR1 35
  • 91.5 (n)
  • 97.96 (a)
LOH12CR1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOH12CR1 35
  • 92.69 (n)
  • 95.92 (a)
LOH12CR1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Loh12cr1 35
  • 87.91 (n)
  • 95.85 (a)
Loh12cr1 16
Loh12cr1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LOH12CR1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LOH12CR1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Loh12cr1 35
  • 87.91 (n)
  • 94.82 (a)
chicken
(Gallus gallus)
Aves LOH12CR1 35
  • 80.63 (n)
  • 89.39 (a)
LOH12CR1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LOH12CR1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia loh12cr1 35
  • 74.78 (n)
  • 82.38 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18715 35
loh12cr1 35
  • 72.96 (n)
  • 82.78 (a)
loh12cr1 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009657 35
  • 46.63 (n)
  • 32.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11802 35
  • 49.26 (n)
  • 37.78 (a)
CG11802 36
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F59E12.11 36
  • 19 (a)
OneToOne
Species with no ortholog for LOH12CR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LOH12CR1 Gene

ENSEMBL:
Gene Tree for LOH12CR1 (if available)
TreeFam:
Gene Tree for LOH12CR1 (if available)

Paralogs for LOH12CR1 Gene

No data available for Paralogs for LOH12CR1 Gene

Variants for LOH12CR1 Gene

Sequence variations from dbSNP and Humsavar for LOH12CR1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9412 -- 12,465,963(+) TTCCC(A/G)GTGTG utr-variant-3-prime, intron-variant
rs714480 -- 12,399,448(-) TCTAC(A/C)TTACC intron-variant
rs879445 -- 12,441,740(+) AGCCC(A/C)CTGTG intron-variant
rs888198 -- 12,396,569(+) TCACC(A/G)TACTG intron-variant
rs888199 -- 12,402,311(+) AGAGT(C/T)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LOH12CR1 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv898808 CNV Gain 21882294
nsv818893 CNV Loss 17921354
esv2745568 CNV Deletion 23290073
dgv15n64 CNV Loss 17921354
nsv437141 CNV Loss 16327808
dgv269e199 CNV Deletion 23128226
dgv187n27 CNV Loss 19166990
esv2421794 CNV Deletion 20811451
nsv517152 CNV Loss 19592680
nsv442636 CNV CNV 18776908
nsv514649 CNV Loss 21397061
esv2673347 CNV Deletion 23128226
nsv513696 OTHER Inversion 21212237
esv994164 OTHER Inversion 20482838
nsv436659 OTHER Inversion 17901297
esv2506365 OTHER Inversion 19546169
nsv513697 OTHER Inversion 21212237
esv1628398 OTHER Inversion 17803354
esv5706 OTHER Inversion 19470904
esv2662165 CNV Deletion 23128226
nsv898810 CNV Loss 21882294
esv271155 CNV Insertion 20981092
esv274447 CNV Insertion 20981092

Relevant External Links for LOH12CR1 Gene

HapMap Linkage Disequilibrium report
LOH12CR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LOH12CR1 Gene

Disorders for LOH12CR1 Gene

Relevant External Links for LOH12CR1

Genetic Association Database (GAD)
LOH12CR1
genes like me logo Genes that share disorders with LOH12CR1: view

No data available for UniProtKB/Swiss-Prot for LOH12CR1 Gene

Publications for LOH12CR1 Gene

  1. A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus. (PMID: 11896457) Montpetit A. … Sinnett D. (Eur. J. Hum. Genet. 2002) 2 3 4
  2. Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia. (PMID: 15284860) Montpetit A. … Sinnett D. (Leukemia 2004) 2 3
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PMID: 20473970) Teixeira F.R. … Gomes M.D. (Proteomics 2010) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for LOH12CR1 Gene

Sources for LOH12CR1 Gene

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