LOC81691 Gene
protein-coding GIFtS : 40
GCID: GC16 P020817
LOC81691
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Aliasesfor LOC81691 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Exonuclease NEF-Sp2 Putative RNA Exonuclease NEF-Sp2 EC 3.1.-.-3
Export aliases for LOC81691 gene to outside databases Previous GC identifers: GC16P020226 GC16P020826 GC16P020785 GC16P020786 GC16P020725 GC16P019353
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Summariesfor LOC81691 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for LOC81691
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Genomic Viewsfor LOC81691 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010393.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the LOC81691 gene promoter: POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 Nkx2-5 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B Other transcription factors Search SABiosciences Chromatin IP Primers for LOC81691 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat LOC81691
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16p12.3 Ensembl cytogenetic band: 16p12.3 LOC81691 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P020817: view genomic region
(about GC identifiers )
Start:
20,817,751 bp from pter
End:
20,860,990 bp from pter
Size:
43,240 bases
Orientation:
plus strand
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Proteinsfor LOC81691 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: REXON_HUMAN, Q96IC2 (See
protein sequence )Recommended Name: Putative RNA exonuclease NEF-sp Size : 774 amino acids; 86886 Da
Sequence caution : Sequence=AAC31668.1; Type=Erroneous gene model prediction;
Secondary accessions : B2RB19 O60364 Q96MB1 Q9BXH9 Q9H0K2 Q9NSM2Alternative splicing : 2 isoforms : Q96IC2-1 Q96IC2-2 Explore the universe of human proteins at neXtProt for LOC81691: NX_Q96IC2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96IC2 LOC81691 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001138396.1 NP_001185982.1 NP_112203.2 ENSEMBL proteins: ENSP00000457789 ENSP00000455233 ENSP00000456227 ENSP00000261377 ENSP00000261378 ENSP00000456643 ENSP00000454262 ENSP00000455677 ENSP00000456030 ENSP00000456182 ENSP00000457616 ENSP00000456666 ENSP00000455139 ENSP00000458004 ENSP00000455867 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
LOC81691 for ontologies About GeneDecksing LOC81691 Antibody Products: Assay Products for LOC81691:
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Protein
Domains / Familiesfor LOC81691 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
LOC81691 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96IC2 ProtoNet protein and cluster: Q96IC2
3 Blocks protein families : IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB006055 Exonuclease IPB013520 Exonuclease UniProtKB/Swiss-Prot: REXON_HUMAN, Q96IC2 Similarity : Contains 1 exonuclease domainSimilarity : Contains 2 RRM (RNA recognition motif) domains
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Functionfor LOC81691 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Enzyme Number (IUBMB): EC 3.1.-.- 1 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for LOC81691 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for LOC81691 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): LOC81691 (NM_001199053 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LOC81691 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat LOC81691
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOC81691
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
LOC81691 for ontologies About GeneDecksing
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Pathways & Interactionsfor LOC81691 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LOC81691 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for LOC81691 (ENSP00000261377 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor LOC81691 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for LOC81691 Search CenterWatch for drugs/clinical trials and news about LOC81691 / REXON
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Transcriptsfor LOC81691 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for LOC81691 gene (3 alternative transcripts): NM_001144924.1 NM_001199053.1 NM_030941.2 Unigene Cluster for LOC81691:
Exonuclease NEF-sp Hs.177926 [show with all ESTs ] Unigene Representative Sequence: NM_001199053 18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20 ): ENST00000568894 ENST00000568046 ENST00000566993 ENST00000261377 (uc002dhy.4 uc002dhv.3 uc002dhx.3 )ENST00000348433 ENST00000568501 ENST00000566276 ENST00000568476 ENST00000565340 ENST00000568647 ENST00000566518 ENST00000564274 ENST00000563068 ENST00000567297 ENST00000564687 ENST00000563617 ENST00000564200 ENST00000563045 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for LOC81691 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for LOC81691 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): LOC81691 (NM_001199053 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LOC81691 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat LOC81691
Additional cDNA sequence: AF332193.1 AK314458.1 AL136763.2 AL162035.1 BC007646.1 BC068503.1
20 DOTS entries : DT.316850 DT.92425131
DT.95157822 DT.120704377 DT.100708036 DT.92425136 DT.92425140 DT.70104805 DT.100838282 DT.101969871 DT.95100440 DT.100762557 DT.95157817 DT.95157821 DT.102831033 DT.120704284 DT.120704364 DT.120704395 DT.75103588 DT.95192645 24/206 AceView cDNA sequences (see all 206 ):
BM783610 AA947564 BM742833 BM753792 BM750622 BM742818 AA334475 AI242900 AW651730 BP371662 BM704533 AI198356 AL136763 BP371661 BM784394 AI167897 AI240583 CD244382 BM783371 BM742303 BI828580 AI967994 BM743018 BX115403 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for LOC81691 About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 SP1 :     -             SP2 :                
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Expression for LOC81691 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section LOC81691 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATAAGTTTT
About this image LOC81691 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)Bone, Cartilage, Limb Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See LOC81691 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for LOC81691 SOURCE GeneReport for Unigene cluster: Hs.177926 SABiosciences Custom PCR Arrays for LOC81691 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for LOC81691Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat LOC81691 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat LOC81691 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat LOC81691 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOC81691
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Orthologsfor LOC81691 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for LOC81691 gene from 6/23 species (see all 23 ) About this table
ENSEMBL Gene Tree for LOC81691 (if available)TreeFam Gene Tree for LOC81691 (if available)
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Paralogsfor LOC81691 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for LOC81691 gene REXO1L2P 2 REXO1L11P 2 REXO1L1 2 REXO1 2 1 SIMAP similar gene for LOC81691 using alignment to 11 protein entries: H3BM72_HUMAN (see all proteins ):ISG20
LOC81691 for paralogs About GeneDecksing
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Genomic Variantsfor LOC81691 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for LOC81691 (20817751 - 20860990 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for LOC81691: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing LOC81691
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Disorders
/ Diseasesfor LOC81691 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor LOC81691 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for LOC81691 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with LOC81691) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 Wiemann S.... Poustka A. (2001) Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829) 1 , 2 Loftus B.J.... Adams M.D. (1999) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) The LIFEdb database in 2006. (PubMed id 16381901) 1 Mehrle A....Wiemann S. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336) 1 Wiemann S....Poustka A. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for LOC81691 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing LOC81691 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing LOC81691 gene
(According to HUGE )
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Specialized Databases showing LOC81691 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for LOC81691 gene: Search GeneIP for patents involving LOC81691 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor LOC81691 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for LOC81691 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for LOC81691 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for LOC81691 OriGene Protein Over-expression Lysate for LOC81691 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for LOC81691 OriGene 3'-UTR Clone for LOC81691 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for LOC81691 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for LOC81691 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for LOC81691 OriGene Custom Protein Services for LOC81691 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LOC81691 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing LOC81691 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat LOC81691 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat LOC81691 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat LOC81691 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat LOC81691
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOC81691
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat LOC81691
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Aliases for LOC81691
Databases for LOC81691
Disorders / Diseases for LOC81691
Domains / Families for LOC81691
Drugs / Compounds for LOC81691
Expression for LOC81691
Function for LOC81691
Genomic Views for LOC81691
Intellectual Property for LOC81691
Orthologs for LOC81691
Paralogs for LOC81691
Pathways / Interactions for LOC81691
Products for LOC81691
Proteins for LOC81691
Publications for LOC81691
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Summaries for LOC81691
Transcripts for LOC81691
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