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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LOC81691 Gene

protein-coding   GIFtS: 40
GCID: GC16P020817

LOC81691


  Search for LOC81691
in our new
 Human Malady Compendium 
Biological research products
for LOC81691
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Exonuclease NEF-Sp2
Putative RNA Exonuclease NEF-Sp2
EC 3.1.-.-3

External Ids:    Entrez Gene: 816912   Ensembl: ENSG000000051897   UniProtKB: Q96IC23   

Export aliases for LOC81691 gene to outside databases

Previous GC identifers: GC16P020226 GC16P020826 GC16P020785 GC16P020786 GC16P020725 GC16P019353


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for LOC81691


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LOC81691 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Nkx2-5   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for LOC81691

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LOC81691


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   

LOC81691 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOC81691 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P020817:  view genomic region     (about GC identifiers)

Start:
20,817,751 bp from pter      End:
20,860,990 bp from pter
Size:
43,240 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: REXON_HUMAN, Q96IC2 (See protein sequence)
Recommended Name: Putative RNA exonuclease NEF-sp  
Size: 774 amino acids; 86886 Da
Sequence caution: Sequence=AAC31668.1; Type=Erroneous gene model prediction;
Secondary accessions: B2RB19 O60364 Q96MB1 Q9BXH9 Q9H0K2 Q9NSM2
Alternative splicing: 2 isoforms:  Q96IC2-1   Q96IC2-2   

Explore the universe of human proteins at neXtProt for LOC81691: NX_Q96IC2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96IC2

  • LOC81691 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138396.1  NP_001185982.1  NP_112203.2  

    ENSEMBL proteins: 
     ENSP00000457789   ENSP00000455233   ENSP00000456227   ENSP00000261377   ENSP00000261378  
     ENSP00000456643   ENSP00000454262   ENSP00000455677   ENSP00000456030   ENSP00000456182  
     ENSP00000457616   ENSP00000456666   ENSP00000455139   ENSP00000458004   ENSP00000455867  

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    Novus Biologicals LOC81691 Protein
    Novus Biologicals LOC81691 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005730nucleolus IDA--


    LOC81691 for ontologies           About GeneDecksing



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    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    LOC81691 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR006055 Exonuclease
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR012337 RNaseH-like_dom
     IPR013520 Exonuclease_RNaseT/DNA_pol3

    Graphical View of Domain Structure for InterPro Entry Q96IC2

    ProtoNet protein and cluster: Q96IC2

    3 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB006055 Exonuclease
    IPB013520 Exonuclease


    UniProtKB/Swiss-Prot: REXON_HUMAN, Q96IC2
    Similarity: Contains 1 exonuclease domain
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Enzyme Number (IUBMB): EC 3.1.-.-1

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004527exonuclease activity IEA--


    LOC81691 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LOC81691

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for LOC81691 (ENSP000002613774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGBP1ENSP000003487844STRING: ENSP00000348784
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LOC81691
    Search CenterWatch for drugs/clinical trials and news about LOC81691 / REXON 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LOC81691 gene (3 alternative transcripts): 
    NM_001144924.1  NM_001199053.1  NM_030941.2  

    Unigene Cluster for LOC81691:

    Exonuclease NEF-sp
    Hs.177926  [show with all ESTs]
    Unigene Representative Sequence: NM_001199053
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000568894 ENST00000568046 ENST00000566993 ENST00000261377(uc002dhy.4 uc002dhv.3 uc002dhx.3)
    ENST00000348433 ENST00000568501 ENST00000566276 ENST00000568476 ENST00000565340
    ENST00000568647 ENST00000566518 ENST00000564274 ENST00000563068 ENST00000567297
    ENST00000564687 ENST00000563617 ENST00000564200 ENST00000563045

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF332193.1 AK314458.1 AL136763.2 AL162035.1 BC007646.1 BC068503.1 

    20 DOTS entries:

    DT.316850  DT.92425131  DT.95157822  DT.120704377  DT.100708036  DT.92425136  DT.92425140  DT.70104805 
    DT.100838282  DT.101969871  DT.95100440  DT.100762557  DT.95157817  DT.95157821  DT.102831033  DT.120704284 
    DT.120704364  DT.120704395  DT.75103588  DT.95192645 

    24/206 AceView cDNA sequences (see all 206):

    BM783610 AA947564 BM742833 BM753792 BM750622 BM742818 AA334475 AI242900 
    AW651730 BP371662 BM704533 AI198356 AL136763 BP371661 BM784394 AI167897 
    AI240583 CD244382 BM783371 BM742303 BI828580 AI967994 BM743018 BX115403 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LOC81691    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:              -                                 
    SP2:                                                



    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LOC81691 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATAAGTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    LOC81691 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)Bone, Cartilage, Limb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LOC81691 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LOC81691

    SOURCE GeneReport for Unigene cluster: Hs.177926
        SABiosciences Custom PCR Arrays for LOC81691
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOC81691

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LOC81691 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC4270011 exonuclease NEF-sp 59.56(n)
    51.25(a)
      427001  NM_001006573.1  NP_001006573.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    38(a)
    1 ↔ 1
    GL343402.1(793954-806161)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83683   -- 35(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C05C8.53   -- 44(a)   V(7235337-7237413)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SDN36
    AT5G258006
    (see all 5)
    small RNA degrading nuclease 5
    (see all 5)
    9(a)
    20(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    5(26824236-26828171)
    5(8979622-8982873)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    exonuclease, putative, expressed
    19(a)
    17(a)
    possible ortholog
    possible ortholog
    4(32964319-32968180)
    12(4468455-4474419)


    ENSEMBL Gene Tree for LOC81691 (if available)
    TreeFam Gene Tree for LOC81691 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LOC81691 gene
    REXO1L2P2  REXO1L11P2  REXO1L12  REXO12  
    1 SIMAP similar gene for LOC81691 using alignment to 11 protein entries:     H3BM72_HUMAN (see all proteins):
    ISG20

    LOC81691 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/638 NCBI SNPs in LOC81691 are shown (see all 638    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887920681,2
    --20815777(+) AGCTCC/TGGAGT 5 -- us2k1 int10--------
    rs1932140771,2
    --20815784(+) GAGTTC/TGAGAC 5 -- int1 us2k10--------
    rs340822071,2
    C,F,--20815913(+) AGCCCA/GGGAGG 5 -- us2k1 int15Minor allele frequency- G:0.40NA WA 10
    rs1845135891,2
    --20816408(+) CACAGA/CGCATC 5 -- int1 us2k10--------
    rs740118751,2
    C,--20816434(+) ACACAA/GTAATT 5 -- int1 us2k12Minor allele frequency- G:0.14WA 120
    rs1881539061,2
    --20816459(+) AAAGGA/CTCACT 5 -- int1 us2k10--------
    rs1455125921,2
    --20816476(+) GGCACC/TGTGGC 5 -- int1 us2k10--------
    rs1488392991,2
    --20816477(+) GCACCA/GTGGCT 5 -- int1 us2k10--------
    rs1918100791,2
    --20816518(+) TGAGGC/TGGGTG 5 -- us2k1 int10--------
    rs1434531481,2
    --20816546(+) AGTTCA/GAGAAC 5 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for LOC81691 (20817751 - 20860990 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LOC81691: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LOC81691 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with LOC81691)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81691 AceView: LOC81691 Ensembl:ENSG00000005189 euGenes: HUgn81691

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LOC81691 gene:
    Search GeneIP for patents involving LOC81691

    GeneCards and IP:
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