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Aliases for LOC81691 Gene

Aliases for LOC81691 Gene

  • Exonuclease NEF-Sp 3
  • Putative RNA Exonuclease NEF-Sp 5
  • AC004381.6 5
  • EC 3.1.-.- 4

External Ids for LOC81691 Gene

Previous GeneCards Identifiers for LOC81691 Gene

  • GC16P020226
  • GC16P020826
  • GC16P020785
  • GC16P020786
  • GC16P020725
  • GC16P019353

Summaries for LOC81691 Gene

GeneCards Summary for LOC81691 Gene

LOC81691 (Exonuclease NEF-Sp) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is MIR1909.

Gene Wiki entry for LOC81691 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOC81691 Gene

Genomics for LOC81691 Gene

Regulatory Elements for LOC81691 Gene

Enhancers for LOC81691 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F021505 1.4 Ensembl ENCODE 11.4 +703.6 703621 9.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC NPIPB5 THUMPD1 LOC646828 LOC342293 ENSG00000260306 LOC81691 C16orf52 RRN3P1 SMG1P1 PIR36552
GH16F020743 1.3 Ensembl ENCODE 11.9 -60.3 -60345 4.3 HDGF PKNOX1 ATF1 ARNT CREB3L1 ELK1 GATA2 CBX5 FOS KLF13 THUMPD1 ACSM3 LOC81691 ERI2 GC16P020744 ENSG00000260510
GH16F021501 1.2 ENCODE 11.4 +696.1 696101 2.5 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 THUMPD1 NPIPB5 ENSG00000260635 SMG1P1 SMG1P4 MFSD13B RRN3P1 EEF2K ENSG00000260306 DCUN1D3
GH16F021515 1.2 Ensembl ENCODE 11.4 +709.3 709267 0.6 PKNOX1 MLX ARID4B FEZF1 ZNF121 GLIS2 KLF7 MIER2 TSHZ1 PPARG LOC646828 LOC342293 LOC81691 SLC7A5P2 PIR36552 SMG1P3
GH16F021517 1.1 ENCODE 11.4 +713.8 713800 4.7 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 THUMPD1 LOC646828 LOC342293 LOC81691 RRN3P1 METTL9 SMG1P1 SMG1P4 NPIPB5 SLC7A5P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LOC81691 on UCSC Golden Path with GeneCards custom track

Promoters for LOC81691 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001504193 171 2401 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13

Genomic Location for LOC81691 Gene

20,806,429 bp from pter
20,849,668 bp from pter
43,240 bases
Plus strand

Genomic View for LOC81691 Gene

Genes around LOC81691 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOC81691 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOC81691 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOC81691 Gene

Proteins for LOC81691 Gene

  • Protein details for LOC81691 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative RNA exonuclease NEF-sp
    Protein Accession:
    Secondary Accessions:
    • B2RB19
    • O60364
    • Q96MB1
    • Q9BXH9
    • Q9H0K2
    • Q9NSM2

    Protein attributes for LOC81691 Gene

    774 amino acids
    Molecular mass:
    86886 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC31668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LOC81691 Gene


neXtProt entry for LOC81691 Gene

Post-translational modifications for LOC81691 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LOC81691 Gene

Domains & Families for LOC81691 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 exonuclease domain.
  • Contains 1 exonuclease domain.
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with LOC81691: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for LOC81691 Gene

Function for LOC81691 Gene

Enzyme Numbers (IUBMB) for LOC81691 Gene

Gene Ontology (GO) - Molecular Function for LOC81691 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with LOC81691: view

Phenotypes for LOC81691 Gene

genes like me logo Genes that share phenotypes with LOC81691: view

Animal Model Products

miRNA for LOC81691 Gene

miRTarBase miRNAs that target LOC81691

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LOC81691 Gene

Localization for LOC81691 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LOC81691 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for LOC81691 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LOC81691: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LOC81691 Gene

Pathways & Interactions for LOC81691 Gene

genes like me logo Genes that share pathways with LOC81691: view

Pathways by source for LOC81691 Gene

1 KEGG pathway for LOC81691 Gene

Gene Ontology (GO) - Biological Process for LOC81691 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with LOC81691: view

No data available for SIGNOR curated interactions for LOC81691 Gene

Transcripts for LOC81691 Gene

Unigene Clusters for LOC81691 Gene

Exonuclease NEF-sp:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LOC81691 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -

Relevant External Links for LOC81691 Gene

GeneLoc Exon Structure for

Expression for LOC81691 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LOC81691 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LOC81691 Gene

This gene is overexpressed in Testis (38.0) and Ovary (30.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LOC81691 Gene

Protein tissue co-expression partners for LOC81691 Gene

SOURCE GeneReport for Unigene cluster for LOC81691 Gene:

genes like me logo Genes that share expression patterns with LOC81691: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LOC81691 Gene

Orthologs for LOC81691 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LOC81691 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC453977 34
  • 99.27 (n)
-- 35
  • 97 (a)
(Canis familiaris)
Mammalia LOC479820 34
  • 89.18 (n)
-- 35
  • 84 (a)
(Bos Taurus)
Mammalia MGC134577 34
  • 87.02 (n)
-- 35
  • 81 (a)
(Rattus norvegicus)
Mammalia Exnef 34
  • 79.69 (n)
(Mus musculus)
Mammalia 2610020H08Rik 34 16 35
  • 73.35 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 49 (a)
(Gallus gallus)
Aves LOC427001 34
  • 59.21 (n)
-- 35
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158551 34
  • 57.18 (n)
(Danio rerio)
Actinopterygii zgc:152968 35
  • 6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8368 36 35
  • 35 (a)
(Caenorhabditis elegans)
Secernentea C05C8.5 36 35
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNH70 35
  • 20 (a)
Species where no ortholog for LOC81691 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LOC81691 Gene

Gene Tree for LOC81691 (if available)
Gene Tree for LOC81691 (if available)

Paralogs for LOC81691 Gene

Paralogs for LOC81691 Gene

genes like me logo Genes that share paralogs with LOC81691: view

Variants for LOC81691 Gene

Sequence variations from dbSNP and Humsavar for LOC81691 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111309156 -- 20,833,330(+) CCCAG(A/C)AGGCC intron-variant
rs111356370 -- 20,840,465(+) ACCCG(C/T)CAGGT nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs111418107 -- 20,835,428(+) CTAAA(C/T)CATTC intron-variant
rs111542868 -- 20,813,153(+) ATAAC(A/C)AATAA intron-variant
rs111752290 -- 20,818,599(+) CTGAG(G/T)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LOC81691 Gene

Variant ID Type Subtype PubMed ID
esv3638158 CNV loss 21293372
nsv1050009 CNV loss 25217958
nsv436835 CNV insertion 17901297
nsv833165 CNV loss 17160897

Variation tolerance for LOC81691 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LOC81691 Gene

Disorders for LOC81691 Gene

Relevant External Links for LOC81691

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LOC81691 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LOC81691 Gene

Publications for LOC81691 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64

Products for LOC81691 Gene

Sources for LOC81691 Gene

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