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Aliases for LOC81691 Gene

Aliases for LOC81691 Gene

  • Exonuclease NEF-Sp 3
  • Putative RNA Exonuclease NEF-Sp 5
  • AC004381.6 5
  • EC 3.1.-.- 4

External Ids for LOC81691 Gene

Previous GeneCards Identifiers for LOC81691 Gene

  • GC16P020226
  • GC16P020826
  • GC16P020785
  • GC16P020786
  • GC16P020725
  • GC16P019353

Summaries for LOC81691 Gene

GeneCards Summary for LOC81691 Gene

LOC81691 (Exonuclease NEF-Sp) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is REXO1.

Gene Wiki entry for LOC81691 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOC81691 Gene

Genomics for LOC81691 Gene

Regulatory Elements for LOC81691 Gene

Enhancers for LOC81691 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LOC81691 on UCSC Golden Path with GeneCards custom track

Promoters for LOC81691 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LOC81691 on UCSC Golden Path with GeneCards custom track

Genomic Location for LOC81691 Gene

20,806,429 bp from pter
20,849,668 bp from pter
43,240 bases
Plus strand

Genomic View for LOC81691 Gene

Genes around LOC81691 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOC81691 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOC81691 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOC81691 Gene

Proteins for LOC81691 Gene

  • Protein details for LOC81691 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative RNA exonuclease NEF-sp
    Protein Accession:
    Secondary Accessions:
    • B2RB19
    • O60364
    • Q96MB1
    • Q9BXH9
    • Q9H0K2
    • Q9NSM2

    Protein attributes for LOC81691 Gene

    774 amino acids
    Molecular mass:
    86886 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC31668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LOC81691 Gene


neXtProt entry for LOC81691 Gene

Proteomics data for LOC81691 Gene at MOPED

Post-translational modifications for LOC81691 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LOC81691 Gene

Domains & Families for LOC81691 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 exonuclease domain.
  • Contains 1 exonuclease domain.
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with LOC81691: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for LOC81691 Gene

Function for LOC81691 Gene

Enzyme Numbers (IUBMB) for LOC81691 Gene

Gene Ontology (GO) - Molecular Function for LOC81691 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with LOC81691: view

Phenotypes for LOC81691 Gene

GenomeRNAi human phenotypes for LOC81691:
genes like me logo Genes that share phenotypes with LOC81691: view

Animal Model Products

CRISPR Products

miRNA for LOC81691 Gene

miRTarBase miRNAs that target LOC81691

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LOC81691 Gene

Localization for LOC81691 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LOC81691 Gene

Pathways & Interactions for LOC81691 Gene

genes like me logo Genes that share pathways with LOC81691: view

Pathways by source for LOC81691 Gene

1 KEGG pathway for LOC81691 Gene

Interacting Proteins for LOC81691 Gene

Gene Ontology (GO) - Biological Process for LOC81691 Gene


No data available for SIGNOR curated interactions for LOC81691 Gene

Drugs & Compounds for LOC81691 Gene

No Compound Related Data Available

Transcripts for LOC81691 Gene

Unigene Clusters for LOC81691 Gene

Exonuclease NEF-sp:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LOC81691 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -

Relevant External Links for LOC81691 Gene

GeneLoc Exon Structure for

Expression for LOC81691 Gene

mRNA expression in normal human tissues for LOC81691 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LOC81691 Gene

This gene is overexpressed in Testis (38.0) and Ovary (30.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LOC81691 Gene

SOURCE GeneReport for Unigene cluster for LOC81691 Gene Hs.177926

genes like me logo Genes that share expression patterns with LOC81691: view

Protein tissue co-expression partners for LOC81691 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LOC81691 Gene

Orthologs for LOC81691 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LOC81691 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MGC134577 35
  • 87.02 (n)
  • 83.33 (a)
-- 36
  • 81 (a)
(Canis familiaris)
Mammalia LOC479820 35
  • 89.18 (n)
  • 84.99 (a)
-- 36
  • 84 (a)
(Mus musculus)
Mammalia 2610020H08Rik 35
  • 73.35 (n)
  • 61.67 (a)
2610020H08Rik 16
2610020H08Rik 36
  • 59 (a)
(Pan troglodytes)
Mammalia LOC453977 35
  • 99.27 (n)
  • 99.22 (a)
-- 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Exnef 35
  • 79.69 (n)
  • 71.02 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
(Gallus gallus)
Aves LOC427001 35
  • 59.21 (n)
  • 50.56 (a)
-- 36
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158551 35
  • 57.18 (n)
  • 48.93 (a)
(Danio rerio)
Actinopterygii zgc:152968 36
  • 6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8368 37
  • 35 (a)
CG8368 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea C05C8.5 37
  • 44 (a)
C05C8.5 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNH70 36
  • 20 (a)
Species with no ortholog for LOC81691:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LOC81691 Gene

Gene Tree for LOC81691 (if available)
Gene Tree for LOC81691 (if available)

Paralogs for LOC81691 Gene

Paralogs for LOC81691 Gene

genes like me logo Genes that share paralogs with LOC81691: view

Variants for LOC81691 Gene

Sequence variations from dbSNP and Humsavar for LOC81691 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs6654 -- 20,849,575(-) ATAAA(A/G)CTGTC utr-variant-3-prime
rs14557 -- 20,849,473(-) ACGAA(A/C)ACAGG reference, missense
rs13337246 -- 20,826,700(+) actct(A/G)taacc intron-variant
rs9925428 -- 20,847,607(+) AGAAC(C/T)GCTTT intron-variant
rs4783506 -- 20,811,745(+) TGTTT(C/T)GCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LOC81691 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833165 CNV Loss 17160897

Variation tolerance for LOC81691 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LOC81691 Gene

Disorders for LOC81691 Gene

No disorders were found for LOC81691 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for LOC81691 Gene

Publications for LOC81691 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for LOC81691 Gene

Sources for LOC81691 Gene