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LOC728763 Gene

protein-coding   GIFtS: 21
GCID: GC02P241868          (predicted)

Rootletin-Like


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
rootletin-like2

External Ids:    Entrez Gene: 7287632   Ensembl: ENSG000002263217   UniProtKB: H0YGE44   UniProtKB: H7BZ684   UniProtKB: H7C0M94   
UniProtKB: H7C1104   UniProtKB: H7C1174   UniProtKB: H7C1824   

Export aliases for LOC728763 gene to outside databases

Previous GC identifers: GC02P241517 GC02P241847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LOC728763 Gene:
LOC728763 is a protein-coding gene. An important paralog of this gene is CROCC.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LOC728763 gene promoter:
         NF-1   AML1a   p300   CUTL1   HNF-1A   YY1   HEN1   HNF-1   Zic1   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LOC728763


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   

LOC728763 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOC728763 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P241868:  view genomic region     (about GC identifiers)

Start:
241,858,202 bp from pter      End:
241,932,728 bp from pter
Size:
74,527 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/TrEMBL: H0YGE4 (See protein sequence)
Recommended Name: Protein LOC728763  
Size: 268 amino acids; 30188 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H7BZ68 (See protein sequence)

Recommended Name: Protein LOC728763  
Size: 163 amino acids; 18728 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H7C0M9 (See protein sequence)

Recommended Name: Protein LOC728763  
Size: 186 amino acids; 20758 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H7C110 (See protein sequence)

Recommended Name: Protein LOC728763  
Size: 250 amino acids; 28199 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H7C117 (See protein sequence)

Recommended Name: Protein LOC728763  
Size: 242 amino acids; 27831 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H7C182 (See protein sequence)

Recommended Name: Protein LOC728763  
Size: 270 amino acids; 29758 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

Explore proteomics data for LOC728763 at MOPED


See LOC728763 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000398937   ENSP00000442937   ENSP00000395829   ENSP00000388085   ENSP00000397844  
 ENSP00000397968   ENSP00000387851  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR026733 Rootletin

Graphical View of Domain Structure for InterPro Entry H0YGE4
Graphical View of Domain Structure for InterPro Entry H7BZ68
Graphical View of Domain Structure for InterPro Entry H7C0M9
Graphical View of Domain Structure for InterPro Entry H7C110
Graphical View of Domain Structure for InterPro Entry H7C117
Graphical View of Domain Structure for InterPro Entry H7C182

ProtoNet protein and cluster: H0YGE4


Find genes that share domains with LOC728763           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for LOC728763

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0035253ciliary rootlet ----

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LOC728763
Interactions:

    Search GeneGlobe Interaction Network for LOC728763

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

Selected Interacting proteins for LOC728763 (ENSP000003878514) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
InteractantInteraction Details
GeneCardExternal ID(s)
TBCDENSP000003477194STRING: ENSP00000347719
PRC1ENSP000003777934STRING: ENSP00000377793
VBP1ENSP000002864284STRING: ENSP00000286428
MAPRE1ENSP000003647214STRING: ENSP00000364721
MAPRE3ENSP000002331214STRING: ENSP00000233121
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0051297centrosome organization ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for LOC728763



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for LOC728763:

Rootletin-like
Hs.647892  [show with all ESTs]
Unigene Representative Sequence: XM_003118518
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000427156 ENST00000545144 ENST00000477311 ENST00000440780 ENST00000420530
ENST00000480779 ENST00000442811 ENST00000443866 ENST00000430980
miRNA
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Inhib. RNA
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Primer
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Additional mRNA sequence: XM_003118518.1 

7 DOTS entries:

DT.121033310  DT.120943472  DT.120943471  DT.121011394  DT.121011395  DT.121011396  DT.91681226 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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LOC728763 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
LOC728763 Expression
About this image

LOC728763 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LOC728763 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.647892
    Custom PCR Arrays for LOC728763
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for LOC728763 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia E030010N08Rik1 RIKEN cDNA E030010N08 gene 70.45(n)
62.69(a)
  381284  XM_006529984.1  XP_006530047.1 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
10(a)
many ↔ many
20(1293307-1299162) ENSGALG00000026151
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
24(a)
1 ↔ 1
3(29896944-29991587)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-95g8.16
si:ch211-95g8.1
17(a)
1 ↔ 1
6(27070206-27158732) ENSDARG00000017425
fruit fly
(Drosophila melanogaster)
Insecta Rootletin6
Rootletin
9(a)
1 → many
3R(19939317-19953915)


ENSEMBL Gene Tree for LOC728763 (if available)
TreeFam Gene Tree for LOC728763 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for LOC728763 gene
CROCC2  CEP2502  
2 SIMAP similar genes for LOC728763 using alignment to 6 protein entries:     H0YGE4_HUMAN (see all proteins):
CROCCP2    CROCC

Find genes that share paralogs with LOC728763           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for LOC728763 (see all 923)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs740001381,2
C,F--241229581(+) ATCGAA/GGTAAC 1 -- us2k12Minor allele frequency- G:0.03WA 120
rs740001391,2
C,F--241229587(+) GTAACG/ATGTCT 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1872691391,2
--241229682(+) TTATCA/CCGCTT 1 -- us2k10--------
rs1901632661,2
--241229698(+) TTCGCA/GGAACC 1 -- us2k10--------
rs1380937511,2
--241229753(+) TTGCCA/GGGGCT 1 -- us2k10--------
rs1831010951,2
--241229787(+) AGCTCA/CGGCTA 1 -- us2k10--------
rs582864641,2
C,F--241229861(+) ACCCTA/CGACTA 1 -- us2k11Minor allele frequency- C:0.17EA 120
rs67451711,2
C,H--241229899(+) tttccA/G/Tgtcca 1 -- us2k114NA WA CSA EA 377
rs1494986161,2
--241230004(+) ATTCTC/TTCCCA 1 -- us2k10--------
rs607987241,2
C,F--241230034(+) TTAACT/CCACAT 1 -- us2k11Minor allele frequency- C:0.17EA 120

HapMap Linkage Disequilibrium report for LOC728763 (241858202 - 241932728 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for LOC728763: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing LOC728763
DNA2.0 Custom Variant and Variant Library Synthesis for LOC728763

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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  --

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 728763 Ensembl:ENSG00000226321 euGenes: HUgn728763

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LOC728763 gene:
Search GeneIP for patents involving LOC728763

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      LOC728763 gene at Home site.
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