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Aliases for LOC255308 Gene

Aliases for LOC255308 Gene

  • Eukaryotic Translation Initiation Factor 2 Subunit Gamma Pseudogene 3
  • EIF2S3L 4 5
  • Putative Eukaryotic Translation Initiation Factor 2 Subunit 3-Like Protein 5
  • Eukaryotic Translation Initiation Factor 2 Subunit Gamma A 4
  • EIF-2-Gamma A 4
  • EIF-2gA 4

External Ids for LOC255308 Gene

Previous GeneCards Identifiers for LOC255308 Gene

  • GC12P010362
  • GC12P010802
  • GC12P010558
  • GC12P010659

Summaries for LOC255308 Gene

GeneCards Summary for LOC255308 Gene

LOC255308 (Eukaryotic Translation Initiation Factor 2 Subunit Gamma Pseudogene) is a Pseudogene. GO annotations related to this gene include GTP binding and translation initiation factor activity. An important paralog of this gene is EIF2S3.

UniProtKB/Swiss-Prot for LOC255308 Gene

  • As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LOC255308 Gene

Genomics for LOC255308 Gene

Regulatory Elements for LOC255308 Gene


Enhancers around LOC255308 on UCSC Golden Path with GeneCards custom track

Genomic Location for LOC255308 Gene

Chromosome:
12
Start:
10,505,602 bp from pter
End:
10,523,135 bp from pter
Size:
17,534 bases
Orientation:
Plus strand

Genomic View for LOC255308 Gene

Genes around LOC255308 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LOC255308 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LOC255308 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LOC255308 Gene

Proteins for LOC255308 Gene

  • Protein details for LOC255308 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VIR3-IF2GL_HUMAN
    Recommended name:
    Putative eukaryotic translation initiation factor 2 subunit 3-like protein
    Protein Accession:
    Q2VIR3
    Secondary Accessions:
    • Q5I0X0
    • Q6KF84

    Protein attributes for LOC255308 Gene

    Size:
    472 amino acids
    Molecular mass:
    51229 Da
    Quaternary structure:
    • The eukaryotic translation initiation factor 2 complex/eIF2 is a heterotrimer composed of an alpha, a beta and a gamma subunit.
    SequenceCaution:
    • Sequence=ABB92405.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA07331.1; Type=Frameshift; Positions=304; Evidence={ECO:0000305};

    Alternative splice isoforms for LOC255308 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LOC255308 Gene

Post-translational modifications for LOC255308 Gene

No Post-translational modifications

Other Protein References for LOC255308 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for LOC255308 Gene

Domains & Families for LOC255308 Gene

Suggested Antigen Peptide Sequences for LOC255308 Gene

Graphical View of Domain Structure for InterPro Entry

Q2VIR3

UniProtKB/Swiss-Prot:

IF2GL_HUMAN :
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
genes like me logo Genes that share domains with LOC255308: view

No data available for Gene Families for LOC255308 Gene

Function for LOC255308 Gene

Molecular function for LOC255308 Gene

UniProtKB/Swiss-Prot Function:
As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity).

Gene Ontology (GO) - Molecular Function for LOC255308 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 translation initiation factor activity IEA --
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with LOC255308: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LOC255308 Gene

Localization for LOC255308 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LOC255308 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LOC255308 Gene

Pathways & Interactions for LOC255308 Gene

SuperPathways for LOC255308 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LOC255308 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
genes like me logo Genes that share ontologies with LOC255308: view

No data available for Pathways by source and SIGNOR curated interactions for LOC255308 Gene

Drugs & Compounds for LOC255308 Gene

(1) Drugs for LOC255308 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with LOC255308: view

Transcripts for LOC255308 Gene

mRNA/cDNA for LOC255308 Gene

(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for LOC255308 Gene

No ASD Table

Relevant External Links for LOC255308 Gene

GeneLoc Exon Structure for
LOC255308

Expression for LOC255308 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LOC255308 Gene

Protein differential expression in normal tissues from HIPED for LOC255308 Gene

This gene is overexpressed in Breast (22.2), Peripheral blood mononuclear cells (16.0), Cervix (9.9), and Heart (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LOC255308 Gene



Protein tissue co-expression partners for LOC255308 Gene

mRNA Expression by UniProt/SwissProt for LOC255308 Gene:

Q2VIR3-IF2GL_HUMAN
Tissue specificity: Specifically expressed in testis at the mRNA level.
genes like me logo Genes that share expression patterns with LOC255308: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LOC255308 Gene

Orthologs for LOC255308 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LOC255308 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia EIF2S3 35
  • 91 (a)
ManyToMany
-- 35
  • 89 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eif2s3x 35
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves EIF2S3 35
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 90 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii eif2s3 35
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta eIF-2gamma 35
  • 75 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y39G10AR.8 35
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCD11 35
  • 59 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3195 34
rice
(Oryza sativa)
Liliopsida Os.12630 34
wheat
(Triticum aestivum)
Liliopsida Ta.2663 34
corn
(Zea mays)
Liliopsida Zm.6871 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 78 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5353 34
Species where no ortholog for LOC255308 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for LOC255308 Gene

ENSEMBL:
Gene Tree for LOC255308 (if available)
TreeFam:
Gene Tree for LOC255308 (if available)

Paralogs for LOC255308 Gene

Paralogs for LOC255308 Gene

genes like me logo Genes that share paralogs with LOC255308: view

Variants for LOC255308 Gene

Variation tolerance for LOC255308 Gene

Gene Damage Index Score: 8.91; 87.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for LOC255308 Gene

Disorders for LOC255308 Gene

Relevant External Links for LOC255308

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LOC255308

No disorders were found for LOC255308 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LOC255308 Gene

Publications for LOC255308 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  2. Emergence of young human genes after a burst of retroposition in primates. (PMID: 16201836) Marques A.C. … Kaessmann H. (PLoS Biol. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for LOC255308 Gene

Sources for LOC255308 Gene

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