LOC100133315 Gene
protein-coding GIFtS: 26
GCID: GC11M071576
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LOC100133315
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Aliases
for LOC100133315 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 2
| Aliases |
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| Transient Receptor Potential Cation Channel, Subfamily C, Member 2-Like2 | | TrpC2-Like Protein3 |
| External Ids: | Entrez Gene: 1001333152 | Ensembl: ENSG000002544697 | UniProtKB: Q6ZNB53 | | ORGUL members: | |
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| NONCODE:n408310 | |
Export aliases for LOC100133315 gene to outside databasesPrevious GC identifers: GC11U900991 GC11M071254
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Summaries
for LOC100133315 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LOC100133315 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LOC100133315 gene promoter:
ISGF-3 AML1a E4BP4 RORalpha2 FOXL1 RORalpha1 IRF-2 COMP1 c-Myb Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for LOC100133315
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LOC100133315 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 LOC100133315 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M071576: view genomic region
(about GC identifiers)
Start:
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71,576,555 bp from pter |
End:
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71,639,700 bp from pter |
Size:
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63,146 bases |
Orientation:
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minus strand |
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Proteins
for LOC100133315 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRC2L_HUMAN, Q6ZNB5 (See
protein sequence)Recommended Name: Putative short transient receptor potential channel 2-like protein Size: 142 amino acids; 15763 Da
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for LOC100133315: NX_Q6ZNB5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZNB5
LOC100133315 Protein expression data from MOPED and PaxDb: --
ENSEMBL proteins: ENSP00000436725 ENSP00000434508 ENSP00000432246 ENSP00000433692 ENSP00000433080 ENSP00000435060 ENSP00000435620 ENSP00000436412 ENSP00000435720
Human Recombinant Protein Products for LOC100133315:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
LOC100133315 for ontologies About GeneDecksing
LOC100133315 Antibody Products:
Assay Products for LOC100133315: |
Protein
Domains /
Families
for LOC100133315 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LOC100133315 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZNB5ProtoNet protein and cluster: Q6ZNB5 UniProtKB/Swiss-Prot: TRC2L_HUMAN, Q6ZNB5Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily |
Function
for LOC100133315 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003684 | damaged DNA binding |
IEA | -- |
LOC100133315 for ontologies About GeneDecksing
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOC100133315 |
|
Pathways & Interactions
for LOC100133315 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LOC100133315
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000012 | single strand break repair |
IEA | -- |
LOC100133315 for ontologies About GeneDecksing
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Drugs & Compounds
for LOC100133315 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LOC100133315
Search CenterWatch for drugs/clinical trials and news about LOC100133315 / TRC2L 
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Transcripts
for LOC100133315 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for LOC100133315: Transient receptor potential cation channel, subfamily C, member 2-like Hs.150324 [show with all ESTs]Unigene Representative Sequence: AK02156610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000532852(uc021qmt.1) ENST00000528511 ENST00000528560 ENST00000530333
ENST00000529844(uc001oqz.2) ENST00000529513 ENST00000533047 ENST00000534704
ENST00000528184 ENST00000531488
Additional cDNA sequence: AK021566.1 NR_029192.1 7 DOTS entries: DT.92037249 DT.99928410 DT.40207972 DT.40310681 DT.95141913 DT.40129933 DT.120692977
GeneLoc Exon Structure
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Expression
for LOC100133315 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LOC100133315 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.150324
SABiosciences Custom PCR Arrays for LOC100133315
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat LOC100133315 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LOC100133315 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LOC100133315 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOC100133315 |
Orthologs
for LOC100133315 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for LOC100133315 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1102246 |
zgc:110224 |
20(a) |
1 ↔ 1 |
21(29484787-29505906) |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
6(a) |
1 → many |
Group10.25(207246-208821) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATXRCC16 |
DNA-repair protein XRCC1 |
1(a) |
1 → many |
1(30235164-30238535) |
rice
(Oryza sativa) |
Liliopsida |
-- |
BRCA1 C Terminus domain containing protein, expres... |
2(a) |
1 → many |
6(2328884-2333475) |
ENSEMBL Gene Tree for LOC100133315 (if available)
TreeFam Gene Tree for LOC100133315 (if available) |
Paralogs
for LOC100133315 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LOC100133315 gene
- XRCC12
LOC100133315 for paralogs About GeneDecksing
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Genomic Variants
for LOC100133315 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LOC100133315 (71576555 - 71639700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for LOC100133315
5 CNVs: 35013 3857 85847 71350 71351 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for LOC100133315 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 LOC100133315 for disorders About MalaCards
LOC100133315 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: LOC100133315 (1 document)
Export disorders for LOC100133315 gene to outside databases
|
Publications
for LOC100133315 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LOC100133315 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LOC100133315) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Characterization of TRPC2, an essential genetic compo nent of VNS chemoreception, provides insights into the evolution of pheromonal olfaction in secondary-adapted marine mammals. (PubMed id 20142439)1 Yu L....Zhang Y.P. (2010)
- TRPC2: molecular biology and functional importance. (PubMed id 17217050)1 Yildirim E. and Birnbaumer L. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for LOC100133315 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing LOC100133315 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing LOC100133315 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LOC100133315 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for LOC100133315 gene:
Search GeneIP for patents involving LOC100133315
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LOC100133315 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LOC100133315 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LOC100133315 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LOC100133315 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LOC100133315 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LOC100133315 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LOC100133315 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LOC100133315 |
|  |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LOC100133315 |
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