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LOC100133315 Gene

protein-coding   GIFtS: 23
GCID: GC11M071576

Transient Receptor Potential Cation Channel, Subfamily C,...


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transient Receptor Potential Cation Channel, Subfamily C, Member 2-Like2
TrpC2-Like Protein3

External Ids:    Entrez Gene: 1001333152   Ensembl: ENSG000002544697   UniProtKB: Q6ZNB53   

Export aliases for LOC100133315 gene to outside databases

Previous GC identifers: GC11U900991 GC11M071254


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LOC100133315 Gene:
LOC100133315 is a protein-coding gene. GO annotations related to this gene include damaged DNA binding. An important paralog of this gene is XRCC1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LOC100133315 gene promoter:
         ISGF-3   AML1a   E4BP4   RORalpha2   FOXL1   RORalpha1   IRF-2   COMP1   c-Myb   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LOC100133315


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   

LOC100133315 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LOC100133315 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M071576:  view genomic region     (about GC identifiers)

Start:
71,576,555 bp from pter      End:
71,639,700 bp from pter
Size:
63,146 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for LOC100133315

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRC2L_HUMAN, Q6ZNB5 (See protein sequence)
Recommended Name: Putative short transient receptor potential channel 2-like protein  
Size: 142 amino acids; 15763 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for LOC100133315: NX_Q6ZNB5

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • ENSEMBL proteins: 
     ENSP00000436725   ENSP00000434508   ENSP00000432246   ENSP00000433080   ENSP00000435060  
     ENSP00000435620   ENSP00000436412   ENSP00000435720  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002706 Xrcc1_N
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry Q6ZNB5

    ProtoNet protein and cluster: Q6ZNB5

    UniProtKB/Swiss-Prot: TRC2L_HUMAN, Q6ZNB5
    Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily


    LOC100133315 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding IEA--
         
    LOC100133315 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    LOC100133315 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LOC100133315
    Interactions:

        Search GeneGlobe Interaction Network for LOC100133315

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000012single strand break repair IEA--

    LOC100133315 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LOC100133315 (TRC2L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    Unigene Cluster for LOC100133315:

    Transient receptor potential cation channel, subfamily C, member 2-like
    Hs.150324  [show with all ESTs]
    Unigene Representative Sequence: AK021566
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532852(uc021qmt.1) ENST00000528511 ENST00000528560 ENST00000529844(uc001oqz.2)
    ENST00000529513 ENST00000533047 ENST00000534704 ENST00000528184 ENST00000531488

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    Additional mRNA sequence: 

    AK021566.1 NR_029192.1 

    7 DOTS entries:

    DT.92037249  DT.99928410  DT.40207972  DT.40310681  DT.95141913  DT.40129933  DT.120692977 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LOC100133315 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LOC100133315 Expression
    About this image

    LOC100133315 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.150324
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LOC100133315 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    platypus
    (Ornithorhynchus anatinus)
    Mammalia --
    Uncharacterized protein
    37(a)
    1 ↔ 1
    Contig18845(11912-16299)
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    26(a)
    1 ↔ 1
    1(193362031-193364866) ENSGALG00000017493
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1102246
    zgc:110224
    20(a)
    1 ↔ 1
    21(29484787-29505906) ENSDARG00000032263
    fruit fly
    (Drosophila melanogaster)
    Insecta XRCC16
    XRCC1
    7(a)
    1 → many
    X(5223944-5226468)


    ENSEMBL Gene Tree for LOC100133315 (if available)
    TreeFam Gene Tree for LOC100133315 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LOC100133315 gene
    XRCC12  ENSG000002683612  

    LOC100133315 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LOC100133315 (see all 1483)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17839611,2
    C,F,A--71576095(+) TTATTA/CTCCGT 1 -- int16Minor allele frequency- C:0.12NA WA CSA 251
    rs355626581,2
    C--71576182(+) GAACA-/TTTTTT 1 -- int10--------
    rs1807704921,2
    --71576279(+) GGTTCC/GCGCCA 1 -- int10--------
    rs1117206621,2
    C,F--71576281(+) TTCCCA/GCCATT 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs30162881,2
    C,A--71576304(+) CCTCCC/TAAGTA 1 -- int12Minor allele frequency- T:0.00CSA 2
    rs30162891,2
    C,A--71576365(+) TAGTAC/GAGACG 1 -- int10--------
    rs1899583941,2
    --71576370(+) GAGACA/GGGGTT 1 -- int10--------
    rs29459221,2
    C,A--71576400(-) AGATCA/GAGACA 1 -- int10--------
    rs1825050431,2
    --71576422(+) GATCCA/GCCCAC 1 -- int10--------
    rs1860504051,2
    --71576479(+) TGGACA/GTAACG 1 -- int10--------

    HapMap Linkage Disequilibrium report for LOC100133315 (71576555 - 71639700 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for LOC100133315:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744758CNV Deletion23290073
    dgv223e199CNV Deletion23128226
    esv2744760CNV Deletion23290073
    nsv383CNV Insertion18451855
    nsv509428CNV Insertion20534489
    esv273257CNV Insertion20981092
    esv25167CNV Gain19812545
    dgv1219n71CNV Gain21882294
    nsv428262CNV Gain+Loss18775914
    dgv396e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    LOC100133315 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LOC100133315
    Human Genome Epidemiology (HuGE) Navigator: LOC100133315 (1 document)

    Export disorders for LOC100133315 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LOC100133315 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with LOC100133315)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Characterization of TRPC2, an essential genetic component of VNS chemoreception, provides insights into the evolution of pheromonal olfaction in secondary-adapted marine mammals. (PubMed id 20142439)1 Yu L....Zhang Y.P. (Mol. Biol. Evol. 2010)
    3. TRPC2: molecular biology and functional importance. (PubMed id 17217050)1 Yildirim E. and Birnbaumer L. (Handb Exp Pharmacol 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100133315 Ensembl:ENSG00000254469 euGenes: HUgn100133315

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LOC100133315 gene:
    Search GeneIP for patents involving LOC100133315

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse ESI BIO Cell Lines and PureStem Progenitors for LOC100133315
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for LOC100133315
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     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LOC100133315
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LOC100133315
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     Search LSBio for Antibodies for LOC100133315
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