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Aliases for LNX2 Gene

Aliases for LNX2 Gene

  • Ligand Of Numb-Protein X 2 2 3
  • PDZRN1 3 4 6
  • PDZ Domain-Containing RING Finger Protein 1 3 4
  • PDZ Domain Containing Ring Finger 1 2 3
  • Numb-Binding Protein 2 3 4
  • Ligand Of Numb Protein X 2 3

External Ids for LNX2 Gene

Previous Symbols for LNX2 Gene

  • PDZRN1

Summaries for LNX2 Gene

GeneCards Summary for LNX2 Gene

LNX2 (Ligand Of Numb-Protein X 2) is a Protein Coding gene. Diseases associated with LNX2 include q fever. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is PARD3B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LNX2 Gene

Genomics for LNX2 Gene

Genomic Location for LNX2 Gene

Start:
27,545,911 bp from pter
End:
27,620,583 bp from pter
Size:
74,673 bases
Orientation:
Minus strand

Genomic View for LNX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LNX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LNX2 Gene

Regulatory Elements for LNX2 Gene

Proteins for LNX2 Gene

  • Protein details for LNX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N448-LNX2_HUMAN
    Recommended name:
    Ligand of Numb protein X 2
    Protein Accession:
    Q8N448
    Secondary Accessions:
    • Q5W0P0
    • Q6ZMH2
    • Q96SH4

    Protein attributes for LNX2 Gene

    Size:
    690 amino acids
    Molecular mass:
    76004 Da
    Quaternary structure:
    • Interacts with the phosphotyrosine interaction domain of NUMB.
    SequenceCaution:
    • Sequence=BAD18754.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LNX2 Gene

neXtProt entry for LNX2 Gene

Proteomics data for LNX2 Gene at MOPED

Post-translational modifications for LNX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LNX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LNX2 Gene

Domains for LNX2 Gene

Gene Families for LNX2 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for LNX2 Gene

UniProtKB/Swiss-Prot:

LNX2_HUMAN
Domain:
  • The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient:
    • Q8N448
  • Contains 4 PDZ (DHR) domains.:
    • Q8N448
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8N448
genes like me logo Genes that share domains with LNX2: view

Function for LNX2 Gene

Gene Ontology (GO) - Molecular Function for LNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
GO:0008270 zinc ion binding IEA --
GO:0030165 PDZ domain binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with LNX2: view
genes like me logo Genes that share phenotypes with LNX2: view

miRNA for LNX2 Gene

miRTarBase miRNAs that target LNX2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LNX2 Gene

Localization for LNX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LNX2 Gene COMPARTMENTS Subcellular localization image for LNX2 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for LNX2 Gene

Pathways for LNX2 Gene

SuperPathways for LNX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with LNX2: view

No data available for Pathways by source for LNX2 Gene

Transcripts for LNX2 Gene

mRNA/cDNA for LNX2 Gene

Unigene Clusters for LNX2 Gene

Ligand of numb-protein X 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LNX2 Gene

No ASD Table

Relevant External Links for LNX2 Gene

GeneLoc Exon Structure for
LNX2
ECgene alternative splicing isoforms for
LNX2

Expression for LNX2 Gene

mRNA expression in normal human tissues for LNX2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LNX2 Gene

SOURCE GeneReport for Unigene cluster for LNX2 Gene Hs.132359

genes like me logo Genes that share expressions with LNX2: view

Orthologs for LNX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LNX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LNX2 36
  • 99.37 (n)
  • 99.57 (a)
LNX2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LNX2 36
  • 83.33 (n)
  • 89.15 (a)
LNX2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LNX2 36
  • 87.95 (n)
  • 91.44 (a)
LNX2 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lnx2 36
  • 80.9 (n)
  • 90.52 (a)
Lnx2 16
Lnx2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LNX2 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LNX2 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lnx2 36
  • 81.8 (n)
  • 89.2 (a)
chicken
(Gallus gallus)
Aves LNX2 36
  • 77 (n)
  • 84.21 (a)
LNX2 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LNX2 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lnx2 36
  • 73.58 (n)
  • 80.44 (a)
Str.16970 36
zebrafish
(Danio rerio)
Actinopterygii Dr.11117 36
lnx2a 36
  • 63.75 (n)
  • 69.14 (a)
lnx2a 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta inaD 37
  • 16 (a)
OneToMany
Species with no ortholog for LNX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LNX2 Gene

ENSEMBL:
Gene Tree for LNX2 (if available)
TreeFam:
Gene Tree for LNX2 (if available)

Paralogs for LNX2 Gene

Paralogs for LNX2 Gene

Selected SIMAP similar genes for LNX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LNX2: view

Variants for LNX2 Gene

Sequence variations from dbSNP and Humsavar for LNX2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs482704 -- 27,603,729(+) TCTTC(C/T)ACACA intron-variant
rs498432 -- 27,617,758(-) GATGC(A/G)GTTGT intron-variant
rs506717 -- 27,604,020(+) GAGGC(C/T)GAGGC intron-variant
rs510342 -- 27,604,388(+) GCTAT(C/T)GAGCA intron-variant
rs511644 -- 27,613,210(-) TTAAA(C/T)ACCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LNX2 Gene

Variant ID Type Subtype PubMed ID
nsv899952 CNV Loss 21882294
esv2048214 CNV Deletion 18987734

Relevant External Links for LNX2 Gene

HapMap Linkage Disequilibrium report
LNX2
Human Gene Mutation Database (HGMD)
LNX2

Disorders for LNX2 Gene

(1) MalaCards Diseases for LNX2 Gene

Search for LNX2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for LNX2 Gene

Relevant External Links for LNX2

Genetic Association Database (GAD)
LNX2
Human Genome Epidemiology (HuGE) Navigator
LNX2
genes like me logo Genes that share disorders with LNX2: view

No data available for UniProtKB/Swiss-Prot for LNX2 Gene

Publications for LNX2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4. (PMID: 16832352) Kansaku A. … Hata Y. (Oncogene 2006) 3

Products for LNX2 Gene

Sources for LNX2 Gene

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