LNX2 Gene
protein-coding GIFtS: 49
GCID: GC13M028120
|
|
ligand of numb-protein X 2(Previous name: PDZ domain containing ring finger 1 )
(Previous symbol: PDZRN1)
| |
Aliases
for LNX2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ligand Of Numb-Protein X 21 2 | | PDZ Domain-Containing RING Finger Protein 12 3 | | PDZRN11 2 3 5 | | MGC463151 | | PDZ Domain Containing Ring Finger 11 2 | | Ligand Of Numb Protein X 22 | | Numb-Binding Protein 22 3 | | |
Export aliases for LNX2 gene to outside databasesPrevious GC identifers: GC13U990083 GC13M025918 GC13M027018 GC13M008941 |
Summaries
for LNX2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LNX2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LNX2 gene promoter:
HFH-3 FOXI1 AhR Pbx1a Pax-5 Nkx2-2 Lmo2 Msx-1 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for LNX2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LNX2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.2 Ensembl cytogenetic band: 13q12.2 HGNC cytogenetic band: 13q12.2LNX2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M028120: view genomic region
(about GC identifiers)
Start:
|
28,120,050 bp from pter |
End:
|
28,194,720 bp from pter |
Size:
|
74,671 bases |
Orientation:
|
minus strand |
|
Proteins
for LNX2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LNX2_HUMAN, Q8N448 (See
protein sequence)Recommended Name: Ligand of Numb protein X 2 Size: 690 amino acids; 76004 Da
Subunit: Interacts with the phosphotyrosine interaction domain of NUMB (By similarity)
Sequence caution: Sequence=BAD18754.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for LNX2:2VWR (3D)
Secondary accessions: Q5W0P0 Q6ZMH2 Q96SH4Explore the universe of human proteins at neXtProt for LNX2: NX_Q8N448
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N448
LNX2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_699202.1
ENSEMBL proteins: ENSP00000325929
Human Recombinant Protein Products:
LNX2 Antibody Products:
Assay Products for LNX2: |
Protein
Domains /
Families
for LNX2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LNX2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N448ProtoNet protein and cluster: Q8N448 2 Blocks protein families: IPB001478 PDZ/DHR/GLGF domain IPB001841 Zn-finger
UniProtKB/Swiss-Prot: LNX2_HUMAN, Q8N448Domain: The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficientSimilarity: Contains 4 PDZ (DHR) domainsSimilarity: Contains 1 RING-type zinc finger |
Function
for LNX2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LNX2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LNX2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LNX2 (NM_153371) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LNX2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LNX2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LNX2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
LNX2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for LNX2:
|
Pathways & Interactions
for LNX2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LNX2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/24 Interacting proteins for LNX2 (Q8N4481, 2, 3 ENSP000003259294) via UniProtKB, MINT, STRING, and/or I2D (see all 24)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051260 | protein homooligomerization |
IEA | -- |
LNX2 for ontologies About GeneDecksing
|
Drugs & Compounds
for LNX2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LNX2
Search CenterWatch for drugs/clinical trials and news about LNX2
|
Transcripts
for LNX2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LNX2 gene: NM_153371.3 Unigene Cluster for LNX2: Ligand of numb-protein X 2 Hs.132359 [show with all ESTs]Unigene Representative Sequence: NM_1533711 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000316334(uc001url.4 uc001urm.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LNX2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LNX2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LNX2 (NM_153371) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LNX2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LNX2 |
Additional cDNA sequence: AK022995.1 AK095319.1 AK313394.1 BC036755.2 6 DOTS entries: DT.210268 DT.100022102 DT.91698497 DT.120775986 DT.120776034 DT.120776045 24/65 AceView cDNA sequences (see all 65): Z38767 NM_153371 CA432775 BQ017483 BC036755 AI783640 AK095319 BQ721926 BU686432 AA630753 BM800852 BQ109475 AI700820 BM556292 CN479234 BX281727 BM971327 BE265067 CK429277 BU661862 BU662330 AU129153 BX502753 BE264978
GeneLoc Exon Structure
|
Expression
for LNX2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LNX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACAAGTTT
About this image
See LNX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LNX2
SOURCE GeneReport for Unigene cluster: Hs.132359
SABiosciences Custom PCR Arrays for LNX2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LNX2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LNX2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LNX2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LNX2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LNX2 |
Orthologs
for LNX2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for LNX2 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LNX21 |
ligand of numb-protein X 2 |
76.95(n)
84.21(a) |
|
418928 XM_417122.3 XP_417122.2 |
lizard
(Anolis carolinensis) |
Reptilia |
LNX26-- |
-- |
81(a)22(a) |
1 ↔ 1possible ortholog |
GL343306.1(1224935-1241529) 4(100124972-100180124) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BJ032220.12 |
-- |
73.44(n) |
|
BJ032220.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.111172 |
Transcribed sequence with weak similarity to protein more |
74.54(n) |
|
BG307401.1 |
ENSEMBL Gene Tree for LNX2 (if available)
TreeFam Gene Tree for LNX2 (if available) |
Paralogs
for LNX2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LNX2 gene
- PARD3B2 PDZD22 IL162 INADL2 PARD32 MPDZ2 LNX12
1 SIMAP similar gene for LNX2 using alignment to 1 protein entry: LNX2_HUMAN:LNX1
LNX2 for paralogs About GeneDecksing
|
Genomic Variants
for LNX2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LNX2 (28120050 - 28194720 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LNX2: --
Human Gene Mutation Database (HGMD): LNX2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LNX2 |
|
Disorders
/ Diseases
for LNX2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LNX2 for disorders About GeneDecksing
OMIM gene information: 609733
OMIM disorders: --
2  diseases for LNX2: About MalaCardsq fever endocarditis
1 disease from the University of Copenhagen DISEASES database for LNX2:Q fever Human Genome Epidemiology (HuGE) Navigator: LNX2 (1 document)
Export disorders for LNX2 gene to outside databases
|
Publications
for LNX2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LNX2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with LNX2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
- The ligands of Numb proteins X1 and X2 are specific ma rkers for chronic Q fever. (PubMed id 22066909)1 Mehraj V....Ghigo E. (2012)
- Ligand of Numb proteins LNX1p80 and LNX2 interact wit h the human glycoprotein CD8I+ and promote its ubiquitylation and endocytosis. (PubMed id 22045731)1 D'Agostino M....Mottola G. (2011)
- Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Common variants on 14q32 and 13q12 are associated wit h DLBCL susceptibility. (PubMed id 21471979)1 Kumar V....Matsuda K. (2011)
|
External Searches for LNX2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LNX2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LNX2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LNX2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LNX2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LNX2 gene:
Search GeneIP for patents involving LNX2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LNX2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LNX2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LNX2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LNX2 | | | OriGene Protein Over-expression Lysate for LNX2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LNX2 | | OriGene 3'-UTR Clone for LNX2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LNX2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LNX2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LNX2 | | OriGene Custom Protein Services for LNX2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LNX2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LNX2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LNX2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LNX2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LNX2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LNX2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for LNX2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | LNX2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LNX2 |
|  |  |  | | | | Search ThermoFisher Antibodies for LNX2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LNX2 |
|
|
|
|
