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LNX2 Gene

protein-coding   GIFtS: 51
GCID: GC13M028120

Ligand Of Numb-Protein X 2

(Previous name: PDZ domain containing ring finger 1)
(Previous symbol: PDZRN1)
  See LNX2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ligand Of Numb-Protein X 21 2
PDZRN11 2 3 5
PDZ Domain Containing Ring Finger 11 2
Numb-Binding Protein 22 3
PDZ Domain-Containing RING Finger Protein 12 3
Ligand Of Numb Protein X 22

External Ids:    HGNC: 204211   Entrez Gene: 2224842   Ensembl: ENSG000001395177   OMIM: 6097335   UniProtKB: Q8N4483   

Export aliases for LNX2 gene to outside databases

Previous GC identifers: GC13U990083 GC13M025918 GC13M027018 GC13M008941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LNX2 Gene:
LNX2 (ligand of numb-protein X 2) is a protein-coding gene. Diseases associated with LNX2 include q fever. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is PARD3B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LNX2 gene promoter:
         HFH-3   FOXI1   AhR   Pbx1a   Pax-5   Nkx2-2   Lmo2   Msx-1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLNX2 promoter sequence
   Search Chromatin IP Primers for LNX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LNX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.2   Ensembl cytogenetic band:  13q12.2   HGNC cytogenetic band: 13q12.2

LNX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LNX2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M028120:  view genomic region     (about GC identifiers)

Start:
28,120,050 bp from pter      End:
28,194,720 bp from pter
Size:
74,671 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LNX2_HUMAN, Q8N448 (See protein sequence)
Recommended Name: Ligand of Numb protein X 2  
Size: 690 amino acids; 76004 Da
Subunit: Interacts with the phosphotyrosine interaction domain of NUMB (By similarity)
Sequence caution: Sequence=BAD18754.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for LNX2:
2VWR (3D)    
Secondary accessions: Q5W0P0 Q6ZMH2 Q96SH4

Explore the universe of human proteins at neXtProt for LNX2: NX_Q8N448

Explore proteomics data for LNX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LNX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_699202.1  
    ENSEMBL proteins: 
     ENSP00000325929  

    LNX2 Human Recombinant Protein Products:

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    Novus Biologicals LNX2 Protein
    Novus Biologicals LNX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LNX2

     
    Search eBioscience for Proteins for LNX2 

    LNX2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for LNX2

    LNX2 Assay Products:

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    Cloud-Clone Corp. ELISAs for LNX2
    Cloud-Clone Corp. CLIAs for LNX2
    Search eBioscience for ELISAs for LNX2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001478 PDZ
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8N448

    ProtoNet protein and cluster: Q8N448

    2 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: LNX2_HUMAN, Q8N448
    Domain: The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient
    Similarity: Contains 4 PDZ (DHR) domains
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with LNX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0030165PDZ domain binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with LNX2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for LNX2:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LNX2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LNX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LNX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LNX2

    miRNA
    Products:
        
    miRTarBase miRNAs that target LNX2:
    hsa-mir-155-5p (MIRT020558), hsa-mir-124-3p (MIRT022212)

    Block miRNA regulation of human, mouse, rat LNX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LNX2 (see all 31):
    hsa-miR-498 hsa-miR-328 hsa-miR-181c hsa-miR-548v hsa-miR-1271 hsa-miR-1297 hsa-miR-10b* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidLNX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LNX2

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LNX2 (NM_153371)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LNX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LNX2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LNX2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LNX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LNX2
    Interactions:

        GeneGlobe Interaction Network for LNX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for LNX2 (Q8N4481, 2, 3 ENSP000003259294) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E4F1Q66K892, 3, ENSP000003017274MINT-8207368 I2D: score=1 STRING: ENSP00000301727
    LNX1Q8TBB13, ENSP000002639254I2D: score=3 STRING: ENSP00000263925
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    CD8AP017323, ENSP000002836354I2D: score=1 STRING: ENSP00000283635
    NUMBP497573, ENSP000003471694I2D: score=3 STRING: ENSP00000347169
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051260protein homooligomerization IEA--

    Find genes that share ontologies with LNX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LNX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LNX2 gene: 
    NM_153371.3  

    Unigene Cluster for LNX2:

    Ligand of numb-protein X 2
    Hs.132359  [show with all ESTs]
    Unigene Representative Sequence: NM_153371
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000316334(uc001url.4 uc001urm.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LNX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LNX2 (see all 31):
    hsa-miR-498 hsa-miR-328 hsa-miR-181c hsa-miR-548v hsa-miR-1271 hsa-miR-1297 hsa-miR-10b* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidLNX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LNX2
    Predesigned siRNA for gene silencing in human, mouse, rat LNX2
    Clone
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    OriGene clones in human, mouse for LNX2 (see all 6)
    OriGene ORF clones in mouse, rat for LNX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LNX2 (NM_153371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LNX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LNX2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LNX2
    OriGene qSTAR qPCR primer pairs in human, mouse for LNX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LNX2
      QuantiTect SYBR Green Assays in human, mouse, rat LNX2
      QuantiFast Probe-based Assays in human, mouse, rat LNX2

    Additional mRNA sequence: 

    AK022995.1 AK095319.1 AK313394.1 BC036755.2 

    6 DOTS entries:

    DT.210268  DT.100022102  DT.91698497  DT.120775986  DT.120776034  DT.120776045 

    Selected AceView cDNA sequences (see all 65):

    BQ109475 Z38767 BU686432 BE265067 BM800852 BQ017483 CN479234 NM_153371 
    BC036755 CK429277 BQ721926 BM556292 BX281727 AK095319 AI700820 AA630753 
    CA432775 BM971327 AI783640 BU662330 AK022995 BG928554 AU129153 BU676252 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LNX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACAAGTTT
    LNX2 Expression
    About this image

    LNX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LNX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132359
        Custom PCR Arrays for LNX2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LNX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LNX2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lnx21 , 5 ligand of numb-protein X 21, 5 80.9(n)1
    90.52(a)1
      5 (86.69 cM)5
    1408871  NM_080795.41  NP_542985.41 
     1470166555 
    chicken
    (Gallus gallus)
    Aves LNX21 ligand of numb-protein X 2 77(n)
    84.21(a)
      418928  XM_417122.4  XP_417122.2 
    lizard
    (Anolis carolinensis)
    Reptilia LNX26
    ligand of numb-protein X 2
    84(a)
    1 ↔ 1
    GL343306.1(1221541-1324831)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ032220.12   -- 73.44(n)    BJ032220.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.111172 Transcribed sequence with weak similarity to protein more 74.54(n)    BG307401.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta inaD6
    inactivation no afterpotential D
    16(a)
    1 → many
    2R(18743211-18746317)


    ENSEMBL Gene Tree for LNX2 (if available)
    TreeFam Gene Tree for LNX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LNX2 gene
    PARD3B2  IL162  PDZD22  INADL2  PARD32  MPDZ2  LNX12  
    1 SIMAP similar gene for LNX2 using alignment to 1 protein entry:     LNX2_HUMAN:
    LNX1

    Find genes that share paralogs with LNX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LNX2 (see all 1548)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009783801,2
    --28119553(+) GTTAC-/AAATTT 1 -- ds50010--------
    rs1154584991,2
    C,F--28119555(+) TACAAA/TTTTTT 1 -- ds50011Minor allele frequency- T:0.08WA 118
    rs1841021991,2
    --28119609(+) TGGTAA/GCTCAC 1 -- ds50010--------
    rs1417569261,2
    --28119674(+) CAGTTC/TGAGAC 1 -- ds50010--------
    rs1113388241,2
    F--28119817(+) TTGCAA/GTGAGC 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1138222291,2
    C,F--28119940(+) CTGAGG/ATTTCA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1495268771,2
    --28119942(+) GAGGTC/TTCATG 1 -- ds50010--------
    rs1441243151,2
    C--28119951(+) TGCTCA/GGTGCT 1 -- ds50010--------
    rs766540241,2
    C,F--28119973(+) AAGGAC/TAGTGG 1 -- ds50012Minor allele frequency- T:0.06NA 122
    rs10465241,2
    C,H--28120170(-) TAGTTC/TTGATA 1 -- ut314Minor allele frequency- T:0.00MN NS NA 368

    HapMap Linkage Disequilibrium report for LNX2 (28120050 - 28194720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LNX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2048214CNV Deletion18987734
    nsv899952CNV Loss21882294

    Human Gene Mutation Database (HGMD): LNX2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LNX2
    DNA2.0 Custom Variant and Variant Library Synthesis for LNX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609733    OMIM disorders: --

    1 disease for LNX2:    
    About MalaCards
    q fever

    1 disease from the University of Copenhagen DISEASES database for LNX2:
    Q fever

    Find genes that share disorders with LNX2           About GenesLikeMe

    Genetic Association Database (GAD): LNX2
    Human Genome Epidemiology (HuGE) Navigator: LNX2 (1 document)

    Export disorders for LNX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LNX2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with LNX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/I^-catenin pathway in colorectal cancer. (PubMed id 23319804)1 Camps J....Ried T. (Cancer Res. 2013)
    5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    6. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    7. Protein interactions of the transcription factor Hoxa1. (PubMed id 23088713)1 Lambert B....Rezsohazy R. (BMC Dev. Biol. 2012)
    8. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever. (PubMed id 22066909)1 Mehraj V....Ghigo E. (FEMS Immunol. Med. Microbiol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 222484 HGNC: 20421 AceView: LNX2 Ensembl:ENSG00000139517 euGenes: HUgn222484
    ECgene: LNX2 H-InvDB: LNX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LNX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LNX2 gene:
    Search GeneIP for patents involving LNX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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