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Aliases for LNX2 Gene

Aliases for LNX2 Gene

  • Ligand Of Numb-Protein X 2 2 3
  • PDZ Domain-Containing RING Finger Protein 1 3 4
  • PDZ Domain Containing Ring Finger 1 2 3
  • Numb-Binding Protein 2 3 4
  • PDZRN1 3 4

External Ids for LNX2 Gene

Previous HGNC Symbols for LNX2 Gene

  • PDZRN1

Previous GeneCards Identifiers for LNX2 Gene

  • GC13U990083
  • GC13M025918
  • GC13M027018
  • GC13M028120
  • GC13M008941

Summaries for LNX2 Gene

GeneCards Summary for LNX2 Gene

LNX2 (Ligand Of Numb-Protein X 2) is a Protein Coding gene. Diseases associated with LNX2 include q fever. GO annotations related to this gene include PDZ domain binding. An important paralog of this gene is PARD3B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LNX2 Gene

Genomics for LNX2 Gene

Regulatory Elements for LNX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LNX2 Gene

Chromosome:
13
Start:
27,545,911 bp from pter
End:
27,620,583 bp from pter
Size:
74,673 bases
Orientation:
Minus strand

Genomic View for LNX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LNX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LNX2 Gene

Proteins for LNX2 Gene

  • Protein details for LNX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N448-LNX2_HUMAN
    Recommended name:
    Ligand of Numb protein X 2
    Protein Accession:
    Q8N448
    Secondary Accessions:
    • Q5W0P0
    • Q6ZMH2
    • Q96SH4

    Protein attributes for LNX2 Gene

    Size:
    690 amino acids
    Molecular mass:
    76004 Da
    Quaternary structure:
    • Interacts with the phosphotyrosine interaction domain of NUMB.
    SequenceCaution:
    • Sequence=BAD18754.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LNX2 Gene

neXtProt entry for LNX2 Gene

Proteomics data for LNX2 Gene at MOPED

Post-translational modifications for LNX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LNX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LNX2 Gene

Domains & Families for LNX2 Gene

Gene Families for LNX2 Gene

Protein Domains for LNX2 Gene

Suggested Antigen Peptide Sequences for LNX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N448

UniProtKB/Swiss-Prot:

LNX2_HUMAN :
  • The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient
  • Contains 1 RING-type zinc finger.
Domain:
  • The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient
  • Contains 4 PDZ (DHR) domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with LNX2: view

Function for LNX2 Gene

Gene Ontology (GO) - Molecular Function for LNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
GO:0008270 zinc ion binding IEA --
GO:0030165 PDZ domain binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with LNX2: view
genes like me logo Genes that share phenotypes with LNX2: view

Animal Model Products

miRNA for LNX2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LNX2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LNX2 Gene

Localization for LNX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LNX2 Gene COMPARTMENTS Subcellular localization image for LNX2 gene
Compartment Confidence
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LNX2 Gene

Pathways & Interactions for LNX2 Gene

SuperPathways for LNX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LNX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with LNX2: view

No data available for Pathways by source and SIGNOR curated interactions for LNX2 Gene

Drugs & Compounds for LNX2 Gene

No Compound Related Data Available

Transcripts for LNX2 Gene

mRNA/cDNA for LNX2 Gene

Unigene Clusters for LNX2 Gene

Ligand of numb-protein X 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LNX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LNX2 Gene

No ASD Table

Relevant External Links for LNX2 Gene

GeneLoc Exon Structure for
LNX2
ECgene alternative splicing isoforms for
LNX2

Expression for LNX2 Gene

mRNA expression in normal human tissues for LNX2 Gene

Protein differential expression in normal tissues from HIPED for LNX2 Gene

This gene is overexpressed in Serum (35.5), Placenta (26.4), and Fetal heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LNX2 Gene



SOURCE GeneReport for Unigene cluster for LNX2 Gene Hs.132359

genes like me logo Genes that share expression patterns with LNX2: view

Protein tissue co-expression partners for LNX2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LNX2 Gene

Orthologs for LNX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for LNX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LNX2 35
  • 83.33 (n)
  • 89.15 (a)
LNX2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LNX2 35
  • 87.95 (n)
  • 91.44 (a)
LNX2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lnx2 35
  • 80.9 (n)
  • 90.52 (a)
Lnx2 16
Lnx2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LNX2 35
  • 99.37 (n)
  • 99.57 (a)
LNX2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lnx2 35
  • 81.8 (n)
  • 89.2 (a)
oppossum
(Monodelphis domestica)
Mammalia LNX2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LNX2 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves LNX2 35
  • 77 (n)
  • 84.21 (a)
LNX2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LNX2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lnx2 35
  • 73.58 (n)
  • 80.44 (a)
Str.16970 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11117 35
lnx2a 35
  • 63.75 (n)
  • 69.14 (a)
lnx2a 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta inaD 36
  • 16 (a)
OneToMany
Species with no ortholog for LNX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LNX2 Gene

ENSEMBL:
Gene Tree for LNX2 (if available)
TreeFam:
Gene Tree for LNX2 (if available)

Paralogs for LNX2 Gene

Paralogs for LNX2 Gene

(1) SIMAP similar genes for LNX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LNX2: view

Variants for LNX2 Gene

Sequence variations from dbSNP and Humsavar for LNX2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_024612 -

Structural Variations from Database of Genomic Variants (DGV) for LNX2 Gene

Variant ID Type Subtype PubMed ID
nsv899952 CNV Loss 21882294
esv2048214 CNV Deletion 18987734

Variation tolerance for LNX2 Gene

Residual Variation Intolerance Score: 37.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LNX2 Gene

HapMap Linkage Disequilibrium report
LNX2
Human Gene Mutation Database (HGMD)
LNX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LNX2 Gene

Disorders for LNX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LNX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
q fever
  • infection due to coxiella burnetii
- elite association
Search LNX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LNX2

Genetic Association Database (GAD)
LNX2
Human Genome Epidemiology (HuGE) Navigator
LNX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LNX2
genes like me logo Genes that share disorders with LNX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LNX2 Gene

Publications for LNX2 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  2. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 67
  3. Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/I^-catenin pathway in colorectal cancer. (PMID: 23319804) Camps J. … Ried T. (Cancer Res. 2013) 67
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 67
  5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 67

Products for LNX2 Gene

Sources for LNX2 Gene

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