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Aliases for LNPK Gene

Aliases for LNPK Gene

  • Lunapark, ER Junction Formation Factor 2 3 5
  • KIAA1715 2 3 4
  • Limb And Neural Patterns 2 3
  • LNP 3 4
  • Protein Lunapark 3
  • 2310011O18Rik 3
  • 4921514L11Rik 3
  • Ulnaless 3
  • LNP1 3
  • Ul 3

External Ids for LNPK Gene

Previous HGNC Symbols for LNPK Gene

  • KIAA1715

Summaries for LNPK Gene

GeneCards Summary for LNPK Gene

LNPK (Lunapark, ER Junction Formation Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LNPK Gene

  • Plays a role in tubular endoplasmic reticulum network formation and maintenance. May be involved in limb and central nervous system development.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LNPK Gene

Genomics for LNPK Gene

Regulatory Elements for LNPK Gene

Enhancers for LNPK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G176000 1.4 FANTOM5 ENCODE 13.1 +3.4 3411 2.4 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZBTB7B LNPK HAGLROS GC02M175980
GH02G176075 1.9 VISTA 8.1 -70.6 -70625 1.3 SUZ12 RNF2 TEAD4 CBX2 ZNF407 CEBPG BMI1 CBX8 POLR2A SMARCA4 LNPK EVX2 GC02M176020
GH02G175931 0.5 ENCODE 27.4 +73.4 73431 0.7 TFDP1 FOXA2 JUND EGR2 FOXA1 LNPK ENSG00000229779 GC02M175980
GH02G175852 1.9 Ensembl ENCODE 5.1 +150.4 150380 4.3 ZSCAN4 MAFG MNT RAD21 JUND ZNF316 POLR2A SMARCA4 EMSY MAFK LNPK GC02P175853 GC02P175890
GH02G175999 0.5 Ensembl 18 +5.5 5488 0.2 PKNOX1 PBX2 KDM1A LNPK GC02M175980
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LNPK on UCSC Golden Path with GeneCards custom track

Genomic Location for LNPK Gene

Chromosome:
2
Start:
175,923,862 bp from pter
End:
176,005,388 bp from pter
Size:
81,527 bases
Orientation:
Minus strand

Genomic View for LNPK Gene

Genes around LNPK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LNPK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LNPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LNPK Gene

Proteins for LNPK Gene

  • Protein details for LNPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0E8-LNP_HUMAN
    Recommended name:
    Protein lunapark
    Protein Accession:
    Q9C0E8
    Secondary Accessions:
    • B7ZLA8
    • Q2M2V8
    • Q2YD99
    • Q658W8
    • Q8N5V9
    • Q96MS5

    Protein attributes for LNPK Gene

    Size:
    428 amino acids
    Molecular mass:
    47740 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21806.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LNPK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LNPK Gene

Post-translational modifications for LNPK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LNPK Gene

Domains & Families for LNPK Gene

Protein Domains for LNPK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LNPK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0E8

UniProtKB/Swiss-Prot:

LNP_HUMAN :
  • Belongs to the lunapark family.
Family:
  • Belongs to the lunapark family.
genes like me logo Genes that share domains with LNPK: view

No data available for Gene Families for LNPK Gene

Function for LNPK Gene

Molecular function for LNPK Gene

UniProtKB/Swiss-Prot Function:
Plays a role in tubular endoplasmic reticulum network formation and maintenance. May be involved in limb and central nervous system development.

Gene Ontology (GO) - Molecular Function for LNPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LNPK: view
genes like me logo Genes that share phenotypes with LNPK: view

Animal Model Products

miRNA for LNPK Gene

miRTarBase miRNAs that target LNPK

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LNPK

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LNPK Gene

Localization for LNPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for LNPK Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes to three-way ER tubule junctions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LNPK gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
cytosol 2

Gene Ontology (GO) - Cellular Components for LNPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IDA 24223779
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 12732147
genes like me logo Genes that share ontologies with LNPK: view

Pathways & Interactions for LNPK Gene

No Data Available

Gene Ontology (GO) - Biological Process for LNPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007596 blood coagulation IEA --
GO:0032330 regulation of chondrocyte differentiation IEA --
GO:0035115 embryonic forelimb morphogenesis IEA --
GO:0042733 embryonic digit morphogenesis IEA --
genes like me logo Genes that share ontologies with LNPK: view

No data available for Pathways by source and SIGNOR curated interactions for LNPK Gene

Transcripts for LNPK Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for LNPK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LNPK Gene

No ASD Table

Relevant External Links for LNPK Gene

GeneLoc Exon Structure for
LNPK
ECgene alternative splicing isoforms for
LNPK

Expression for LNPK Gene

NURSA nuclear receptor signaling pathways regulating expression of LNPK Gene:

LNPK

Evidence on tissue expression from TISSUES for LNPK Gene

  • Nervous system(4.6)
  • Adrenal gland(4.2)
  • Liver(4.2)
  • Stomach(4.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LNPK Gene

Orthologs for LNPK Gene

This gene was present in the common ancestor of animals.

Orthologs for LNPK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1715 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia KIAA1715 34 35
  • 92.81 (n)
rat
(Rattus norvegicus)
Mammalia Lnp 34
  • 90.85 (n)
cow
(Bos Taurus)
Mammalia KIAA1715 34 35
  • 90.61 (n)
mouse
(Mus musculus)
Mammalia Lnp 34 35
  • 88.73 (n)
Lnpk 16
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1715 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1715 34 35
  • 76.1 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1715 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1715 34
  • 69.66 (n)
Str.3943 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23923 34
zebrafish
(Danio rerio)
Actinopterygii lnpa 34 35
  • 63.09 (n)
lnpb 35
  • 56 (a)
OneToMany
lnp 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4759 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007983 34
  • 48.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8735 34 35
  • 44.48 (n)
worm
(Caenorhabditis elegans)
Secernentea lnp-1 34 35
  • 42.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8149 35
  • 40 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14484 34
Species where no ortholog for LNPK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LNPK Gene

ENSEMBL:
Gene Tree for LNPK (if available)
TreeFam:
Gene Tree for LNPK (if available)

Paralogs for LNPK Gene

No data available for Paralogs for LNPK Gene

Variants for LNPK Gene

Sequence variations from dbSNP and Humsavar for LNPK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000004733 -- 175,937,377(+) CACAC(C/T)TCCTG nc-transcript-variant, reference, missense
rs1000010144 -- 175,943,494(+) TAATG(A/C)GTATT intron-variant
rs1000020963 -- 175,976,855(+) TAACT(A/G)CAGAT intron-variant
rs1000035682 -- 175,931,838(+) TTTCT(A/G)CTACA intron-variant
rs1000107149 -- 175,951,021(+) TAAAT(C/G)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LNPK Gene

Variant ID Type Subtype PubMed ID
nsv1001873 CNV loss 25217958
nsv1015032 CNV loss 25217958
nsv508120 OTHER sequence alteration 20534489
nsv521343 CNV loss 19592680
nsv953524 CNV duplication 24416366

Variation tolerance for LNPK Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LNPK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LNPK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LNPK Gene

Disorders for LNPK Gene

Relevant External Links for LNPK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LNPK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LNPK

No disorders were found for LNPK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LNPK Gene

Publications for LNPK Gene

  1. ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p. (PMID: 22729086) Chen S. … Ferro-Novick S. (Nat. Cell Biol. 2012) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. (PMID: 25548161) Chen S. … Ferro-Novick S. (Proc. Natl. Acad. Sci. U.S.A. 2015) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for LNPK Gene

Sources for LNPK Gene

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