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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LNPEP Gene

protein-coding GIFtS: 63
GCID: GC05P096272

leucyl/cystinyl aminopeptidase

Explore 28 diseases affiliated with
LNPEP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leucyl/Cystinyl Aminopeptidase¹ ²		AT (4) Receptor²
P-LAP¹ ² ³		Insulin-Regulated Aminopeptidase²
CAP¹ ²		Leucyl-Cystinyl Aminopeptidase²
PLAP¹ ²		Otase¹
Cystinyl Aminopeptidase² ³		Oxytocinase³
Insulin-Regulated Membrane Aminopeptidase² ³		Vasopressinase¹
Insulin-Responsive Aminopeptidase² ³		OTASE³
Placental Leucine Aminopeptidase² ³		OTase³
IRAP² ³		Oxytocinase³
EC 3.4.11.3³ ⁸		EC 3.4.11⁸
Angiotensin IV Receptor²

External Ids:	HGNC: 6656¹	Entrez Gene: 4012²	Ensembl: ENSG00000113441⁷	OMIM: 151300⁵	UniProtKB: Q9UIQ6³

Export aliases for LNPEP gene to outside databases

Previous GC identifers: GC05P095502 GC05P096736 GC05P096300 GC05P096346 GC05P096347 GC05P096297 GC05P091461

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LNPEP:

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin,

dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular

vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The

protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor

for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LCAP_HUMAN, Q9UIQ6

Function: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades

peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during

pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and

dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain

Gene Wiki entry for LNPEP (Cystinyl aminopeptidase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LNPEP gene promoter:
TBP HOXA3 AML1a Sp1 SREBP-1c Egr-4 Meis-1b Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LNPEP promoter sequence

Search SABiosciences Chromatin IP Primers for LNPEP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LNPEP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15 Ensembl cytogenetic band: 5q15 HGNC cytogenetic band: 5q15

LNPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LNPEP gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P096272: view genomic region (about GC identifiers)

Start:	96,271,098 bp from pter	End:	96,373,219 bp from pter
Size:	102,122 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LCAP_HUMAN, Q9UIQ6 (See protein sequence)

Recommended Name: Leucyl-cystinyl aminopeptidase

Size: 1025 amino acids; 117349 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Homodimer. Binds tankyrases 1 and 2

Subcellular location: Cell membrane; Single-pass type II membrane protein. Note=In brain only the membrane-bound form

is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell

surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs,

and/or by interaction with tankyrases

Subcellular location: Leucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted. Note=During pregnancy serum

levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly

after parturition

Sequence caution: Sequence=BAA09436.1; Type=Erroneous initiation; Sequence=BAD92120.1; Type=Frameshift; Positions=405;

Secondary accessions: O00769 Q15145 Q59H76 Q9TNQ2 Q9TNQ3 Q9UIQ7

Alternative splicing: 3 isoforms: Q9UIQ6-1 Q9UIQ6-2 Q9UIQ6-3

Explore the universe of human proteins at neXtProt for LNPEP: NX_Q9UIQ6

Post-translational modifications:

The pregnancy serum form is derived from the membrane-bound form by proteolytic processing¹

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UIQ6

4/11 DME Specific Peptides for LNPEP (Q9UIQ6) (see all 11)

STYLVAF

GYYIVHY

WFGNLVT

WLNEGFA

LNPEP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005566.2 NP_787116.2

ENSEMBL proteins:

ENSP00000231368 ENSP00000379117

Reactome Protein details: Q9UIQ6
Human Recombinant Protein Products for LNPEP:

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	Novus Biologicals LNPEP Proteins Novus Biologicals LNPEP Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LNPEP

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005622	intracellular	IDA	15691326
GO:0005624	membrane fraction	--	--
GO:0005792	microsome	--	--
GO:0005829	cytosol	TAS	--

LNPEP for ontologies About GeneDecksing

LNPEP Antibody Products:

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	Novus Biologicals LNPEP Antibodies
	Abcam antibodies for LNPEP
	Uscn Antibodies for LNPEP
	ThermoFisher Antibody for LNPEP

Assay Products for LNPEP:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LNPEP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LNPEP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LNPEP for domains About GeneDecksing

3 InterPro domains/families:

IPR014782 Peptidase_M1_N

IPR024571 DUF3358

IPR001930 Peptidase_M1

Graphical View of Domain Structure for InterPro Entry Q9UIQ6

ProtoNet protein and cluster: Q9UIQ6

1 Blocks protein family: IPB001930 Membrane alanyl dipeptidase (M1) family signature

UniProtKB/Swiss-Prot: LCAP_HUMAN, Q9UIQ6

Similarity: Belongs to the peptidase M1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LCAP_HUMAN, Q9UIQ6

Function: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades

peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during

pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and

dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain

Catalytic activity: Release of an N-terminal amino acid, Cys- -Xaa-, in which the half-cystine residue is involved in a

disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that

for the cystinyl derivative, however

Enzyme Numbers (IUBMB): EC 3.4.11.3¹ ² EC 3.4.11²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004177	aminopeptidase activity	TAS	15691326
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0008237	metallopeptidase activity	TAS	9177475
GO:0008270	zinc ion binding	IEA	--

LNPEP for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for LNPEP:

Increased gamma-H2AX phosphory

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Lnpep):

behavior/neurological

cardiovascular system

homeostasis/metabolism

no phenotypic analysis

LNPEP for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for LNPEP: Lnpep^tm1.1Sych Lnpep^tm1Ske

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LNPEP

miRNA Products:		OriGene 3'-UTR Clone (see all 2): LNPEP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LNPEP
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate LNPEP (see all 29):
		hsa-miR-125a-5p hsa-miR-29c hsa-miR-29a hsa-miR-301a hsa-miR-507 hsa-miR-125b hsa-miR-3674 hsa-miR-3119

		SwitchGear 3'UTR luciferase reporter plasmid: LNPEP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LNPEP (see all 7) OriGene shRNA RFP: LNPEP Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LNPEP
		Sirion Biotech Custom design and validation of potent shRNA sequences against LNPEP

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for LNPEP
			Sirion Biotech Customized adenovirus for overexpression of LNPEP Sirion Biotech Customized adenovirus for potent knockdown of LNPEP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LNPEP (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LNPEP (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): LNPEP (NM_175920)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LNPEP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LNPEP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LNPEP
		Search LifeMap BioReagents cell lines for LNPEP
		Sirion Biotech Customized stable knockdown cell line services for LNPEP Sirion Biotech Customized inducible knockdown cell line services for LNPEP Sirion Biotech Customized stable overexpressing cell line services for LNPEP Sirion Biotech Customized inducible overexpressing cell line services for LNPEP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LNPEP

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

Antigen processing: Ubiquitination & Proteasome degradation

1.00

Class I MHC mediated antigen processing & presentation

0.83

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Membrane Trafficking

Membrane Trafficking

1.00

Translocation of GLUT4 to the Plasma Membrane

0.32

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for LNPEP

Glucose / Energy Metabolism

1 BioSystems Pathway for LNPEP

Insulin-mediated glucose transport

5/10 Reactome Pathways for LNPEP (see all 10)

	Endosomal/Vacuolar pathway
	Membrane Trafficking
	Antigen processing-Cross presentation
	Translocation of GLUT4 to the Plasma Membrane
	Adaptive Immune System

1 Kegg Pathway (Kegg details for LNPEP):

Renin-angiotensin system

LNPEP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LNPEP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/79 Interacting proteins for LNPEP (Q9UIQ6³ ENSP00000231368⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FHOD1	Q9Y613³, ENSP00000258201⁴	I2D: score=2 STRING: ENSP00000258201
SLC2A4	P14672³, ENSP00000320935⁴	I2D: score=2 STRING: ENSP00000320935
TNKS2	Q9H2K2³, ENSP00000360689⁴	I2D: score=2 STRING: ENSP00000360689
TNKS	O95271³, ENSP00000311579⁴	I2D: score=4 STRING: ENSP00000311579
SMAD9	O15198³	I2D: score=1

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000209	protein polyubiquitination	TAS	--
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	TAS	--
GO:0006508	proteolysis	IEA	--
GO:0007267	cell-cell signaling	TAS	8550619

LNPEP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LNPEP for compounds About GeneDecksing

EMD Millipore small molecules for LNPEP:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LNPEP

4 HMDB Compounds for LNPEP About this table

Compound	Synonyms	CAS #	PubMed Ids
Angiotensin IV	Nle-angiv (see all 13)	12676-15-2	--
Oxytocin	(Arg8)-Vasopressin (see all 22)	50-56-6	--
Vasopressin	3-(Phenylalanine)-8-lysine oxytocin (see all 8)	11000-17-2	--
Zinc	Zinc (see all 2)	7440-66-6	--

10/28 Novoseek chemical compound relationships for LNPEP gene (see all 28) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine-beta-naphthylamide	88.3	1	12649370 (1)
leucine	75.1	195	8235062 (3), 8790909 (3), 12569180 (2), 15218296 (2) (see all 52)
desmopressin	72.7	10	8447444 (2), 15251517 (1), 9578279 (1), 15863571 (1) (see all 8)
cystine	64	30	9013800 (2), 12569180 (1), 1731608 (1), 10448104 (1) (see all 13)
amastatin	58.6	2	15702431 (1)
bestatin	53	1	8577942 (1)
kallidin	52.6	1	14691298 (1)
glucose	41.1	23	10842659 (1), 11981039 (1), 18536739 (1), 7658166 (1) (see all 17)
arginine	29.6	9	9733056 (1), 20500966 (1), 12361682 (1), 8577942 (1) (see all 6)
mannose 6-phosphate	21.8	4	10827003 (1), 11394907 (1)

Search CenterWatch for drugs/clinical trials and news about LNPEP / LCAP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LNPEP gene (2 alternative transcripts):

NM_005575.2 NM_175920.3

Unigene Clusters for LNPEP:

Leucyl/cystinyl aminopeptidase

Hs.527199 [show with all ESTs], Hs.656905 [show with all ESTs]

Unigene Representative Sequences: AK096804, AB208883

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000395784 ENST00000231368(uc003kmv.1 uc003kmw.1) ENST00000395770

ENST00000474122 ENST00000473914

miRNA Products:		OriGene 3'-UTR Clone (see all 2): LNPEP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LNPEP
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate LNPEP (see all 29):
		hsa-miR-125a-5p hsa-miR-29c hsa-miR-29a hsa-miR-301a hsa-miR-507 hsa-miR-125b hsa-miR-3674 hsa-miR-3119

		SwitchGear 3'UTR luciferase reporter plasmid: LNPEP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LNPEP (see all 7) OriGene shRNA RFP: LNPEP Browse OriGene siRNA
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		Sirion Biotech Custom design and validation of potent shRNA sequences against LNPEP

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		GenScript: all cDNA clones in your preferred vector (see all 2): LNPEP (NM_175920)
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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LNPEP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LNPEP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LNPEP

Additional cDNA sequence:

AB208883.1 AK023633.1 AK314226.1 BC028692.1 BC111718.1 BC113117.1 D50810.1 U62768.1

U62769.1

12 DOTS entries:

DT.95122224 DT.305781 DT.455125 DT.95264392 DT.86854391 DT.40235268 DT.65285650 DT.120835213

DT.95272490 DT.97788808 DT.313013 DT.91879191

24/123 AceView cDNA sequences (see all 123):

AA890071 BU075720 BM722799 AK096804 AA332531 BM803696 AI651293 CF529836

AA747425 AW593412 NM_175920 AA767440 BQ015613 AW293768 BF115625 BI909609

AA932506 BC028692 BG760930 AA628943 NM_005575 AI215565 AA932512 BG765528

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LNPEP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTGTAAGA

About this image

LNPEP expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

White adipocyte-like cells (Differentiation of ...)

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LNPEP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LNPEP

SOURCE GeneReport for Unigene clusters: Hs.527199 Hs.656905

UniProtKB/Swiss-Prot: LCAP_HUMAN, Q9UIQ6

Tissue specificity: Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in

neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon

SABiosciences Custom PCR Arrays for LNPEP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LNPEP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LNPEP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LNPEP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LNPEP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LNPEP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LNPEP gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LNPEP¹	leucyl/cystinyl aminopeptidase	70.18(n) 67.19(a)		427279 XM_424862.3 XP_424862.3
lizard (Anolis carolinensis)	Reptilia	LNPEP⁶	--	63(a)	1 ↔ 1	2(26565157-26605860)
African clawed frog (Xenopus laevis)	Amphibia	MGC69084²	hypothetical protein MGC69084	76.6(n)		BC059334.1
zebrafish (Danio rerio)	Actinopterygii	wufb73h12²	wufb73h12	76.12(n)		322814 BC058317.1
honey bee (Apis mellifera)	Insecta	-- --	--	30(a) 28(a)	possible ortholog possible ortholog	GroupUn.6298(9080-17993) Group4.16(111874-116967)
worm (Caenorhabditis elegans)	Secernentea	Y67D8C.9³	--	34(a) (best of 7)		IV(3077664-3086852) --

ENSEMBL Gene Tree for LNPEP (if available)
TreeFam Gene Tree for LNPEP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LNPEP gene

ENPEP² TRHDE² AQPEP² NPEPPS² ENSG00000174093² ANPEP² ERAP1² ERAP2²

8 SIMAP similar genes for LNPEP using alignment to 1 protein entry: LCAP_HUMAN:

ERAP1 ERAP2 TRHDE ANPEP NPEPPS ENPEP

AQPEP FLJ90650

LNPEP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs173732^1,2	C	--	91514826(+)	`atattA/G/Ttatat`	1	--	int¹		2		NA	4
rs17487596^1,2	C,F,H	--	96269407(+)	`TTTAAA/GTATCT`	1	--	us2k¹		8		NA NS EA	668
rs74789684^1,2	C,F	--	96269485(+)	`AGAGCG/ATCTTA`	1	--	us2k¹		4		CSA WA EA	242
rs77229111^1,2	C,F	--	96269540(+)	`TGCGTG/ATACTA`	1	--	us2k¹		4		CSA WA EA	242
rs188626282^1,2		--	96269589(+)	`CACTAC/TTTTTG`	1	--	us2k¹		0	--	--	--	--
rs144725746^1,2		--	96269738(+)	`ATTAAC/TTGGAA`	1	--	us2k¹		0	--	--	--	--
rs116230349^1,2	C,F	--	96269779(+)	`CACCAC/TTATGT`	1	--	us2k¹		1		WA	118
rs145741306^1,2		--	96269994(+)	`GTTTGA/TGGCTA`	1	--	us2k¹		0	--	--	--	--
rs78610773^1,2	C,F	--	96270091(+)	`GCACTA/GAGCAG`	1	--	us2k¹		5		CSA WA NA EA	362
rs113919969^1,2	C	--	96270191(+)	`CTTTGT/ATACCA`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for LNPEP (96271098 - 96373219 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LNPEP
1 CNV: 59280

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LNPEP

DNA2.0 Custom Variant and Variant Library Synthesis for LNPEP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LNPEP for disorders           About GeneDecksing

OMIM gene information: 151300    OMIM disorders: --

20/28 diseases for LNPEP (see all 28):    About MalaCards

diabetes insipidus androgen insensitivity syndrome epithelioid trophoblastic tumor gestational diabetes insipidus

pre-eclampsia placental abruption ectopic pregnancy type 2 diabetes mellitus

placental insufficiency gestational diabetes spontaneous abortion sheehan syndrome

testicular neoplasm pineoblastoma diabetes mellitus seminoma

endometrial carcinoma eclampsia choriocarcinoma pituitary tumor

1 disease from the University of Copenhagen DISEASES database for LNPEP:

pre-eclampsia

10/20 Novoseek disease relationships for LNPEP gene (see all 20) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma	71.2	25	12569180 (2), 8703954 (2), 14691298 (2), 14749039 (2) (see all 12)
central diabetes insipidus	60	1	9201003 (1)
trophoblastic tumor placental site	59.1	1	14691298 (1)
trophoblastic tumor	56.3	1	14691298 (1)
preeclampsia	55.7	18	20150869 (4), 8235062 (3), 7889632 (2), 15894523 (1) (see all 8)
diabetes insipidus nephrogenic	46.6	1	9201003 (1)
abortion threatened	45.6	3	1862862 (2)
hydatidiform mole	44	7	8906012 (3), 12361682 (2)
preterm delivery	36.1	9	11376666 (4), 12569180 (1), 16969009 (1), 15894523 (1) (see all 5)
endometrial carcinoma	23.9	23	15491750 (5), 12684429 (4), 15218296 (3), 16187279 (3)

Human Genome Epidemiology (HuGE) Navigator: LNPEP (3 documents)

Export disorders for LNPEP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LNPEP gene, integrated from 9 sources (see all 220):
(articles sorted by number of sources associating them with LNPEP)

Utopia: connect your pdf to the dynamic
world of online information

Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family. (PubMed id 8550619)^{1, 2, 3, 9} Rogi T.... Tomoda Y. (1996)
Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides. (PubMed id 11389728)^{1, 2, 9} Matsumoto H.... Tsujimoto M. (2001)
Identification of human placental leucine aminopeptidase as oxytocinase. (PubMed id 1731608)^{1, 2, 9} Tsujimoto M....Tomoda Y. (1992)
Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21. (PubMed id 10759854)^{1, 2, 9} Rasmussen T.E.... Kristensen T. (2000)
Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. (PubMed id 11707427)^{1, 2, 9} Albiston A.L....Chai S.Y. (2001)
The complete amino acid sequence of human placental oxytocinase. (PubMed id 9177475)^{1, 2, 9} Laustsen P.G.... Kristensen T. (1997)
Interleukin-1beta stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells. (PubMed id 12569180)^{1, 9} Ikoma Y....Mizutani S. (2003)
Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy. (PubMed id 15894523)^{1, 9} Nomura S....Mizutani S. (2005)
Role of the insulin-regulated aminopeptidase IRAP in insulin action and diabetes. (PubMed id 15187412)^{1, 9} Keller S.R. (2004)
Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta. (PubMed id 10985965)^{1, 9} Nakanishi Y....Mizutani S. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4012	HGNC: 6656	AceView: LNPEP	Ensembl:ENSG00000113441	euGenes: HUgn4012
ECgene: LNPEP	Kegg: 4012	H-InvDB: LNPEP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LNPEP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LNPEP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LNPEP gene:
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GeneCards and IP:
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LNPEP Gene

leucyl/cystinyl aminopeptidase

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LNPEP (Gene Symbol)
Leucyl/Cystinyl Aminopeptidase
P-LAP
CAP
PLAP
Cystinyl Aminopeptidase
Insulin-Regulated Membrane Aminopeptidase
Insulin-Responsive Aminopeptidase
Placental Leucine Aminopeptidase
IRAP
EC 3.4.11.3
Angiotensin IV Receptor
AT (4) Receptor
Insulin-Regulated Aminopeptidase
Leucyl-Cystinyl Aminopeptidase
Otase
Oxytocinase
Vasopressinase
OTASE
OTase
Oxytocinase
EC 3.4.11

Central Diabetes Insipidus
preterm delivery
Infertility
Ovarian Cancer
Carcinoma
Trophoblastic Tumor Placental Site
insulin sensitivity
Hydatidiform Mole
ENDOMETRIAL CARCINOMA
Breast Cancer
Tumors
Trophoblastic Tumor
Adenocarcinoma
Diabetes Insipidus Nephrogenic
Seminoma
NIDDM
Cancer
Preeclampsia
Abortion Threatened
Choriocarcinoma

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LNPEP Gene

leucyl/cystinyl aminopeptidase

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