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LNPEP Gene

protein-coding   GIFtS: 68
GCID: GC05P096272

Leucyl/Cystinyl Aminopeptidase

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucyl/Cystinyl Aminopeptidase1 2     AT (4) Receptor2
Cystinyl Aminopeptidase1 2 3     Insulin-Regulated Aminopeptidase2
Placental Leucine Aminopeptidase1 2 3     Leucyl-Cystinyl Aminopeptidase2
Insulin-Regulated Membrane Aminopeptidase2 3     otase2
Insulin-Responsive Aminopeptidase2 3     oxytocinase2
IRAP2 3     vasopressinase2
P-LAP2 3     OTASE3
EC 3.4.11.33 8     OTase3
CAP2     Oxytocinase3
PLAP2     EC 3.4.118
Angiotensin IV Receptor2     

External Ids:    HGNC: 66561   Entrez Gene: 40122   Ensembl: ENSG000001134417   OMIM: 1513005   UniProtKB: Q9UIQ63   

Export aliases for LNPEP gene to outside databases

Previous GC identifers: GC05P095502 GC05P096736 GC05P096300 GC05P096346 GC05P096347 GC05P096297 GC05P091461


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LNPEP Gene:
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin,
met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in
intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane
glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4)
and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different
isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for LNPEP Gene:
LNPEP (leucyl/cystinyl aminopeptidase) is a protein-coding gene. Diseases associated with LNPEP include gestational diabetes insipidus, and epithelioid trophoblastic tumor. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is ENPEP.

UniProtKB/Swiss-Prot: LCAP_HUMAN, Q9UIQ6
Function: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids.
Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining
homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves
Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain

Gene Wiki entry for LNPEP (Cystinyl aminopeptidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the LNPEP gene promoter:
         TBP   HOXA3   AML1a   Sp1   SREBP-1c   Egr-4   Meis-1b   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LNPEP promoter sequence
   Search Chromatin IP Primers for LNPEP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LNPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

LNPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LNPEP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P096272:  view genomic region     (about GC identifiers)

Start:
96,271,098 bp from pter      End:
96,373,219 bp from pter
Size:
102,122 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LCAP_HUMAN, Q9UIQ6 (See protein sequence)
Recommended Name: Leucyl-cystinyl aminopeptidase  
Size: 1025 amino acids; 117349 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer. Binds tankyrases 1 and 2
Sequence caution: Sequence=BAA09436.1; Type=Erroneous initiation; Sequence=BAD92120.1; Type=Frameshift;
Positions=405;
Secondary accessions: O00769 Q15145 Q59H76 Q9TNQ2 Q9TNQ3 Q9UIQ7
Alternative splicing: 3 isoforms:  Q9UIQ6-1   Q9UIQ6-2   Q9UIQ6-3   

Explore the universe of human proteins at neXtProt for LNPEP: NX_Q9UIQ6

Explore proteomics data for LNPEP at MOPED

Post-translational modifications: 

  • The pregnancy serum form is derived from the membrane-bound form by proteolytic processing1
  • N-glycosylated1
  • Ubiquitination2 at Lys75
  • Glycosylation2 at Asn145, Asn184, Asn215, Asn256, Asn266, Asn368, Asn374, Asn448, Asn525, Asn578,
                                 Asn598, Asn664, Asn682, Asn760, Asn834, Asn850, Asn989
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for LNPEP (Q9UIQ6) (see all 11)
     STYLVAF  GYYIVHY  WFGNLVT  WLNEGFA 


    See LNPEP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005566.2  NP_787116.2  

    ENSEMBL proteins: 
     ENSP00000231368   ENSP00000379117  
    Reactome Protein details: Q9UIQ6

    LNPEP Human Recombinant Protein Products:

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    Novus Biologicals LNPEP Proteins
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    Cloud-Clone Corp. Proteins for LNPEP

    LNPEP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LNPEP Assay Products:

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    Cloud-Clone Corp. ELISAs for LNPEP
    Cloud-Clone Corp. CLIAs for LNPEP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Leucyl-cysteinyl aminopeptidase
    Aminopeptidases

    3 InterPro protein domains:
     IPR014782 Peptidase_M1_N
     IPR024571 ERAP1-like_C_dom
     IPR001930 Peptidase_M1

    Graphical View of Domain Structure for InterPro Entry Q9UIQ6

    ProtoNet protein and cluster: Q9UIQ6

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: LCAP_HUMAN, Q9UIQ6
    Similarity: Belongs to the peptidase M1 family


    LNPEP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LCAP_HUMAN, Q9UIQ6
    Function: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids.
    Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining
    homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves
    Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain
    Catalytic activity: Release of an N-terminal amino acid, Cys- -Xaa-, in which the half-cystine residue is involved
    in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides
    exceed that for the cystinyl derivative, however

         Enzyme Numbers (IUBMB): EC 3.4.11.31 2 EC 3.4.112

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity TAS15691326
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    LNPEP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LNPEP:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lnpep):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  no phenotypic analysis 

    LNPEP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LNPEP: Lnpeptm1.1Sych Lnpeptm1Ske

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LNPEP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LNPEP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LNPEP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LNPEP

    miRNA
    Products:
        
    miRTarBase miRNAs that target LNPEP:
    hsa-mir-361-5p (MIRT044081), hsa-mir-877-5p (MIRT037306), hsa-mir-1 (MIRT023791), hsa-mir-30e-3p (MIRT044123), hsa-mir-744-5p (MIRT037514), hsa-mir-18a-3p (MIRT040837)

    Block miRNA regulation of human, mouse, rat LNPEP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LNPEP (see all 29):
    hsa-miR-125a-5p hsa-miR-29c hsa-miR-29a hsa-miR-301a hsa-miR-507 hsa-miR-125b hsa-miR-3674 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidLNPEP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LNPEP
    Predesigned siRNA for gene silencing in human, mouse, rat LNPEP

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for LNPEP (see all 13)
    OriGene ORF clones in mouse, rat for LNPEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LNPEP (NM_175920)
    Sino Biological Human cDNA Clone for LNPEP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LNPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LNPEP

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LNPEP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LNPEP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LCAP_HUMAN, Q9UIQ6: Cell membrane; Single-pass type II membrane protein. Note=In brain only the membrane-bound
    form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the
    cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization
    motifs, and/or by interaction with tankyrases
    LCAP_HUMAN, Q9UIQ6: Leucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted. Note=During pregnancy serum
    levels are low in the first trimester, rise progressively during the second and third trimester and decrease
    rapidly after parturition
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol4
    endosome4
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005622intracellular IDA15691326
    GO:0005765lysosomal membrane IDA17897319
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS9177475

    LNPEP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LNPEP About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    2CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    4Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Renin-angiotensin system0.37
    5Insulin-mediated glucose transport
    Insulin-mediated glucose transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LNPEP
        EphB-EphrinB Signaling
    Ephrin-Eph Signaling
    Insulin Receptor Pathway

    1 Cell Signaling Technology (CST) Pathway for LNPEP
        Glucose / Energy Metabolism

    1 BioSystems Pathway for LNPEP
        Insulin-mediated glucose transport


    3 Reactome Pathways for LNPEP
        Endosomal/Vacuolar pathway
    Antigen processing: Ubiquitination & Proteasome degradation
    Translocation of GLUT4 to the plasma membrane


    1 Kegg Pathway  (Kegg details for LNPEP):
        Renin-angiotensin system


    LNPEP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LNPEP
    Interactions:

        GeneGlobe Interaction Network for LNPEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LNPEP (Q9UIQ63 ENSP000002313684) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHOD1Q9Y6133, ENSP000002582014I2D: score=2 STRING: ENSP00000258201
    SLC2A4P146723, ENSP000003209354I2D: score=2 STRING: ENSP00000320935
    TNKS2Q9H2K23, ENSP000003606894I2D: score=2 STRING: ENSP00000360689
    TNKSO952713, ENSP000003115794I2D: score=4 STRING: ENSP00000311579
    SMAD9O151983I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0006508proteolysis TAS8550619
    GO:0007267cell-cell signaling TAS8550619

    LNPEP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LNPEP (LCAP)

    4 HMDB Compounds for LNPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Angiotensin IVNle-angiv (see all 13)12676-15-2--
    Oxytocin(Arg8)-Vasopressin (see all 22)50-56-6--
    Vasopressin3-(Phenylalanine)-8-lysine oxytocin (see all 8)11000-17-2--
    ZincZinc (see all 2)7440-66-6--

    Selected Novoseek inferred chemical compound relationships for LNPEP gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine-beta-naphthylamide 88.3 1 12649370 (1)
    leucine 75.1 195 8235062 (3), 8790909 (3), 12569180 (2), 15218296 (2) (see all 52)
    desmopressin 72.7 10 8447444 (2), 15251517 (1), 9578279 (1), 15863571 (1) (see all 8)
    cystine 64 30 9013800 (2), 12569180 (1), 1731608 (1), 10448104 (1) (see all 13)
    amastatin 58.6 2 15702431 (1)
    bestatin 53 1 8577942 (1)
    kallidin 52.6 1 14691298 (1)
    glucose 41.1 23 10842659 (1), 11981039 (1), 18536739 (1), 7658166 (1) (see all 17)
    arginine 29.6 9 9733056 (1), 20500966 (1), 12361682 (1), 8577942 (1) (see all 6)
    mannose 6-phosphate 21.8 4 10827003 (1), 11394907 (1)



    LNPEP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for LNPEP gene (2 alternative transcripts): 
    NM_005575.2  NM_175920.3  

    Unigene Clusters for LNPEP:

    Leucyl/cystinyl aminopeptidase
    Hs.527199  [show with all ESTs], Hs.656905  [show with all ESTs]
    Unigene Representative Sequences: AK096804, AB208883
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395784 ENST00000231368(uc003kmv.1 uc003kmw.1) ENST00000395770
    ENST00000474122 ENST00000473914
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate LNPEP (see all 29):
    hsa-miR-125a-5p hsa-miR-29c hsa-miR-29a hsa-miR-301a hsa-miR-507 hsa-miR-125b hsa-miR-3674 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidLNPEP 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): LNPEP (NM_175920)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LNPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LNPEP
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LNPEP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LNPEP
      QuantiTect SYBR Green Assays in human, mouse, rat LNPEP
      QuantiFast Probe-based Assays in human, mouse, rat LNPEP

    Additional mRNA sequence: 

    AB208883.1 AK023633.1 AK314226.1 BC028692.1 BC111718.1 BC113117.1 D50810.1 U62768.1 
    U62769.1 

    12 DOTS entries:

    DT.95122224  DT.305781  DT.455125  DT.95264392  DT.86854391  DT.40235268  DT.65285650  DT.120835213 
    DT.95272490  DT.97788808  DT.313013  DT.91879191 

    Selected AceView cDNA sequences (see all 123):

    BM803696 AI651293 BU075720 BM722799 AK096804 AA747425 CF529836 AW593412 
    BF115625 BC028692 AA332531 AA890071 AA932506 NM_175920 BQ015613 AW293768 
    AA767440 BI909609 BG764975 AA188721 NM_005575 CF135950 BG622952 AI472924 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LNPEP expression in normal human tissues (normalized intensities)      LNPEP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTGTAAGA
    LNPEP Expression
    About this image


    LNPEP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    LNPEP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LNPEP Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.527199 Hs.656905

    UniProtKB/Swiss-Prot: LCAP_HUMAN, Q9UIQ6
    Tissue specificity: Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in
    neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon

        Custom PCR Arrays for LNPEP
    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LNPEP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lnpep1 , 5 leucyl/cystinyl aminopeptidase1, 5 87.19(n)1
    87.8(a)1
      17 (9.77 cM)5
    2400281  NM_172827.31  NP_766415.11 
     175277235 
    chicken
    (Gallus gallus)
    Aves LNPEP1 leucyl/cystinyl aminopeptidase 70.18(n)
    67.19(a)
      427279  XM_424862.4  XP_424862.3 
    lizard
    (Anolis carolinensis)
    Reptilia LNPEP6
    leucyl/cystinyl aminopeptidase
    63(a)
    1 ↔ 1
    2(26543961-26605860)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690842 hypothetical protein MGC69084 76.6(n)    BC059334.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb73h122 wufb73h12 76.12(n)   322814  BC058317.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119513 membrane alanyl aminopeptidase 39(a)
    (best of 8)
      99A4   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y67D8C.93   -- 34(a)
    (best of 7)
      IV(3077664-3086852)   --


    ENSEMBL Gene Tree for LNPEP (if available)
    TreeFam Gene Tree for LNPEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LNPEP gene
    ENPEP2  TRHDE2  NPEPPS2  AQPEP2  ANPEP2  ERAP12  LOC1010602122  ERAP22  
    9 SIMAP similar genes for LNPEP using alignment to 1 protein entry:     LCAP_HUMAN:
    CD13    ERAP1    ERAP2    TRHDE    ANPEP    NPEPPS
    ENPEP    AQPEP    FLJ90650

    LNPEP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LNPEP (see all 1930)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs174875961,2
    C,F,H--96269407(+) TTTAAA/GTATCT 1 -- us2k18Minor allele frequency- G:0.02NA NS EA 668
    rs747896841,2
    C,F--96269485(+) AGAGCG/ATCTTA 1 -- us2k14Minor allele frequency- A:0.09CSA WA EA 242
    rs772291111,2
    C,F--96269540(+) TGCGTG/ATACTA 1 -- us2k14Minor allele frequency- A:0.09CSA WA EA 242
    rs1886262821,2
    --96269589(+) CACTAC/TTTTTG 1 -- us2k10--------
    rs1447257461,2
    --96269738(+) ATTAAC/TTGGAA 1 -- us2k10--------
    rs1162303491,2
    C,F--96269779(+) CACCAC/TTATGT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1457413061,2
    --96269994(+) GTTTGA/TGGCTA 1 -- us2k10--------
    rs786107731,2
    C,F--96270091(+) GCACTA/GAGCAG 1 -- us2k15Minor allele frequency- G:0.07CSA WA NA EA 362
    rs1139199691,2
    C,F--96270191(+) CTTTGT/ATACCA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1428436141,2
    --96270200(+) CAAAAC/TATGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LNPEP (96271098 - 96373219 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LNPEP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740869CNV Deletion23290073
    esv2730490CNV Deletion23290073
    esv2730489CNV Deletion23290073
    nsv507276CNV Insertion20534489
    nsv819519CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LNPEP
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 151300    OMIM disorders: --

    Selected diseases for LNPEP (see all 30):    About MalaCards
    gestational diabetes insipidus    epithelioid trophoblastic tumor    sheehan syndrome    gestational diabetes
    pineoblastoma    diabetes insipidus    androgen insensitivity syndrome    placental insufficiency
    ectopic pregnancy    placental abruption    choriocarcinoma    seminoma
    endometrial carcinoma    endometrial adenocarcinoma    septic shock    pituitary tumors
    eclampsia    pre-eclampsia    infertility    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for LNPEP:
    pre-eclampsia

    LNPEP for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for LNPEP gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 71.2 25 12569180 (2), 8703954 (2), 14691298 (2), 14749039 (2) (see all 12)
    central diabetes insipidus 60 1 9201003 (1)
    trophoblastic tumor placental site 59.1 1 14691298 (1)
    trophoblastic tumor 56.3 1 14691298 (1)
    preeclampsia 55.7 18 20150869 (4), 8235062 (3), 7889632 (2), 15894523 (1) (see all 8)
    diabetes insipidus nephrogenic 46.6 1 9201003 (1)
    abortion threatened 45.6 3 1862862 (2)
    hydatidiform mole 44 7 8906012 (3), 12361682 (2)
    preterm delivery 36.1 9 11376666 (4), 12569180 (1), 16969009 (1), 15894523 (1) (see all 5)
    endometrial carcinoma 23.9 23 15491750 (5), 12684429 (4), 15218296 (3), 16187279 (3)

    Genetic Association Database (GAD): LNPEP
    Human Genome Epidemiology (HuGE) Navigator: LNPEP (3 documents)

    Export disorders for LNPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LNPEP gene, integrated from 10 sources (see all 227):
    (articles sorted by number of sources associating them with LNPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family. (PubMed id 8550619)1, 2, 3, 9 Rogi T.... Tomoda Y. (J. Biol. Chem. 1996)
    2. Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides. (PubMed id 11389728)1, 2, 9 Matsumoto H.... Tsujimoto M. (Eur. J. Biochem. 2001)
    3. Identification of human placental leucine aminopeptidase as oxytocinase. (PubMed id 1731608)1, 2, 9 Tsujimoto M....Tomoda Y. (Arch. Biochem. Biophys. 1992)
    4. Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21. (PubMed id 10759854)1, 2, 9 Rasmussen T.E.... Kristensen T. (Eur. J. Biochem. 2000)
    5. Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase. (PubMed id 11707427)1, 2, 9 Albiston A.L....Chai S.Y. (J. Biol. Chem. 2001)
    6. The complete amino acid sequence of human placental oxytocinase. (PubMed id 9177475)1, 2, 9 Laustsen P.G.... Kristensen T. (Biochim. Biophys. Acta 1997)
    7. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PubMed id 19578876)1, 4 Johnson M.P....Moses E.K. (Hum. Genet. 2009)
    8. Interleukin-1beta stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells. (PubMed id 12569180)1, 9 Ikoma Y....Mizutani S. (Mol. Hum. Reprod. 2003)
    9. Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy. (PubMed id 15894523)1, 9 Nomura S....Mizutani S. (Biochim. Biophys. Acta 2005)
    10. Role of the insulin-regulated aminopeptidase IRAP in insulin action and diabetes. (PubMed id 15187412)1, 9 Keller S.R. (amp 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4012 HGNC: 6656 AceView: LNPEP Ensembl:ENSG00000113441 euGenes: HUgn4012
    ECgene: LNPEP Kegg: 4012 H-InvDB: LNPEP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LNPEP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LNPEP gene:
    Search GeneIP for patents involving LNPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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