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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LMX1A Gene

protein-coding GIFtS: 54
GCID: GC01M165171

LIM homeobox transcription factor 1, alpha

(Previous symbol: LMX1)

Explore 13 diseases affiliated with
LMX1A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
LIM Homeobox Transcription Factor 1, Alpha¹ ²		LIM Homeobox Transcription Factor 1-Alpha²
LMX1¹ ² ⁵		LMX-1.1³
LMX1.1¹ ²		LIM/Homeobox Protein LMX1A³
LIM/Homeobox Protein 1.1² ³

External Ids:	HGNC: 6653¹	Entrez Gene: 4009²	Ensembl: ENSG00000162761⁷	OMIM: 600298⁵	UniProtKB: Q8TE12³

Export aliases for LMX1A gene to outside databases

Previous GC identifers: GC01U990100 GC01M160823 GC01M161868 GC01M162360 GC01M162358 GC01M161902 GC01M163437 GC01M136417

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LMX1A:

This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that

acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine

producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing

Parkinson's disease. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12

Function: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene

promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS

and developing vertebrae (By similarity)

Gene Wiki entry for LMX1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LMX1A gene promoter:
TBP NRSF form 1 Nkx2-5 Tal-1beta NRSF form 2 AREB6 CP2 IRF-7A ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LMX1A promoter sequence

Search SABiosciences Chromatin IP Primers for LMX1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMX1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.1 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q24.1

LMX1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMX1A gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M165171: view genomic region (about GC identifiers)

Start:	165,171,104 bp from pter	End:	165,325,952 bp from pter
Size:	154,849 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12 (See protein sequence)

Recommended Name: LIM homeobox transcription factor 1-alpha

Size: 382 amino acids; 42747 Da

Subcellular location: Nucleus (By similarity)

Secondary accessions: B3KXP6 Q0VDB5 Q5VWG4 Q8TE11

Alternative splicing: 2 isoforms: Q8TE12-1 Q8TE12-2

Explore the universe of human proteins at neXtProt for LMX1A: NX_Q8TE12

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TE12

LMX1A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001167540.1 NP_796372.1

ENSEMBL proteins:

ENSP00000340226 ENSP00000294816 ENSP00000356868

Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

LMX1A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LMX1A for domains About GeneDecksing

4 InterPro domains/families:

IPR001781 Znf_LIM

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q8TE12

ProtoNet protein and cluster: Q8TE12

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 2 LIM zinc-binding domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12

Function: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene

promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS

and developing vertebrae (By similarity)

Genatlas biochemistry entry for LMX1A:

transcriptional regulator of insulin gene,with the LIM-homeo domain (lmx-1),expressed in pancreatic islets,expressed in

limb mesenchyme through WNT7A induction,involved in dorsoventral polarity of vertebrate limb (dorsal differentiation)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMX1A
		8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate LMX1A (see all 91):
		hsa-miR-548j hsa-miR-520e hsa-miR-1224-3p hsa-miR-1258 hsa-miR-374a hsa-miR-519a hsa-miR-342-3p hsa-miR-502-3p

		SwitchGear 3'UTR luciferase reporter plasmid: LMX1A 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMX1A

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

LMX1A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for LMX1A:

Decreased viability of wild-ty

Animal Models:
Mouse knock-out Lmx1a^tm1.1Tpe for LMX1A
14 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Lmx1a):

behavior/neurological	cellular	craniofacial	embryogenesis	growth/size
hearing/vestibular/ear	integument	limbs/digits/tail	mortality/aging	nervous system
no phenotypic analysis	pigmentation	reproductive system	skeleton

LMX1A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LMX1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/9 Interacting proteins for LMX1A (Q8TE12³ ENSP00000294816⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ISL1	P61371³, ENSP00000230658⁴	I2D: score=2 STRING: ENSP00000230658
LDB1	Q86U70³, ENSP00000392466⁴	I2D: score=2 STRING: ENSP00000392466
LHX3	Q9UBR4³, ENSP00000360811⁴	I2D: score=1 STRING: ENSP00000360811
TCF3	P15923³, ENSP00000262965⁴	I2D: score=1 STRING: ENSP00000262965
BMPR2	Q13873³, ENSP00000363708⁴	I2D: score=2 STRING: ENSP00000363708

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0007411	axon guidance	IEA	--
GO:0007417	central nervous system development	--	--
GO:0010468	regulation of gene expression	--	--

LMX1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LMX1A
Search CenterWatch for drugs/clinical trials and news about LMX1A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LMX1A gene (4 alternative transcripts):

NM_001033507.1 NM_177399.2 NM_001174069.1 NM_177398.3

Unigene Cluster for LMX1A:

LIM homeobox transcription factor 1, alpha

Hs.667312 [show with all ESTs]

Unigene Representative Sequence: NM_177398

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000342310(uc021pdy.1 uc001gcw.2 uc021pdz.1) ENST00000294816(uc001gcz.2)

ENST00000489443 ENST00000367893

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LMX1A
		8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate LMX1A (see all 91):
		hsa-miR-548j hsa-miR-520e hsa-miR-1224-3p hsa-miR-1258 hsa-miR-374a hsa-miR-519a hsa-miR-342-3p hsa-miR-502-3p

		SwitchGear 3'UTR luciferase reporter plasmid: LMX1A 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LMX1A

Additional cDNA sequence:

AK122800.1 AK127724.1 BC066353.1 BC119743.1 BC119744.1

6 DOTS entries:

DT.91848407 DT.102820696 DT.100703604 DT.101980449 DT.97785790 DT.75100467

9 AceView cDNA sequences:

BM720500 BM678780 NM_177398 NM_177399 AK127724 BC066353 BG722259 AW117277

AK122800

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for LMX1A About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:			-										-		-						-
SP2:													-		-						-
SP3:

ECgene alternative splicing isoforms for LMX1A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LMX1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCCTTATG

About this image

LMX1A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Choroid Plexus Progenitor Cells

Choroid Plexus

Neural Tube

Diencephalic Ventricular Zone

Meso-diencephalic Dopaminergic Precursor Cells

Dopaminergic neurons

Neural Tube

Mesencephalic Ventricular Zone

Meso-diencephalic Dopaminergic Precursor Cells

Dopaminergic neurons

Neural Tube

Rhombencephalon

Lateral Rhombic Lip Progenitor Cells

Choroid Plexus

Brain

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

N2/LSB induced-cells (Generation of midbra...)

Midbrain dopaminergic-like neurons (Generation of midbra...)

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

N2/LSB/S/F8-induced cells (Generation of midbra...)

CPEC (Generation of choroi...)

Definitive endoderm-like cells (Generation of mesend...)

See LMX1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LMX1A

SOURCE GeneReport for Unigene cluster: Hs.667312

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12

Tissue specificity: Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively

highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis

SABiosciences Expression via Pathway-Focused PCR Array including LMX1A:

Homeobox (HOX) Genes in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LMX1A gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LMX1A¹	LIM homeobox transcription factor 1, alpha	80.96(n) 87.11(a)		777133 XM_003641657.1 XP_003641705.1
lizard (Anolis carolinensis)	Reptilia	LMX1A⁶	--	76(a)	1 ↔ 1	GL344236.1(25092-38352)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12464²	Xenopus laevis LIM homeobox protein 1b (Lmx1b) mRNA, more	73.61(n)		AF414086.1
zebrafish (Danio rerio)	Actinopterygii	Dr.13964²	Transcribed sequence with weak similarity to protein more	81.1(n)		BI843115.1
fruit fly (Drosophila melanogaster)	Insecta	CG4328⁶ CG32105⁶	--	24(a) 23(a)	many ↔ many many ↔ many	3L(12284056-12289223) 3L(12322332-12329001)
worm (Caenorhabditis elegans)	Secernentea	lim-6⁶	LIM domain family member (lim-6)	30(a)	possible ortholog	X(1074221-1079336)

ENSEMBL Gene Tree for LMX1A (if available)
TreeFam Gene Tree for LMX1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LMX1A gene

LMO2² ISL1² LHX2² LHX9² LMX1B² LMO1² LHX5² LMO4²

LHX6² LHX1² LMO3² LHX4² LHX3² LHX8² ISL2²

12 SIMAP similar genes for LMX1A using alignment to 2 protein entries: LMX1A_HUMAN (see all proteins):

LMX1B LMO3 LMO4 LMO2 ISL1 ISL2

LHX1 LHX4 LHX5 LHX3 LHX8 LHX6

LMX1A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186661115^1,2		--	165170712(+)	`TCAGGA/GAGCCA`	2	--	int¹		0	--	--	--	--
rs192588575^1,2		--	165170713(+)	`CAGGGA/GGCCAC`	2	--	int¹		0	--	--	--	--
rs145006522^1,2		--	165170718(+)	`AGCCAC/TGATCT`	2	--	int¹		0	--	--	--	--
rs12023709^1,2	C,F,A,H,	--	165170720(+)	`CCACGA/GTCTGC`	2	--	int¹		23		NS EA NA WA	2554
rs184737444^1,2		--	165170729(+)	`GCTGCC/TTGGCT`	2	--	int¹		0	--	--	--	--
rs149103376^1,2		--	165170771(+)	`CCTGCA/CTGAGA`	2	--	int¹		0	--	--	--	--
rs143197883^1,2		--	165170822(+)	`CAAATA/GTTCCC`	2	--	int¹		0	--	--	--	--
rs73027262^1,2	C,	--	165170835(+)	`ATCACG/ATATCA`	2	--	int¹		2		WA	120
rs190282689^1,2		--	165170864(+)	`GGGAAC/GTTGAC`	2	--	int¹		0	--	--	--	--
rs181886814^1,2		--	165170870(+)	`TTGACA/GGTGGT`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LMX1A (165171104 - 165325952 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for LMX1A
2 CNVs: 84632 84631

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LMX1A

DNA2.0 Custom Variant and Variant Library Synthesis for LMX1A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LMX1A for disorders           About GeneDecksing

OMIM gene information: 600298    OMIM disorders: --

13 diseases for LMX1A:    About MalaCards

parkinson's disease ovarian mucinous cystadenocarcinoma mucinous cystadenocarcinoma neuronitis

essential hypertension cystadenocarcinoma hypertension cervical cancer

t-cell leukemia cervicitis gastric cancer leukemia

pancreatitis

2 diseases from the University of Copenhagen DISEASES database for LMX1A:

Ovarian mucinous cystadenocarcinoma Parkinson's disease

Genetic Association Database (GAD): LMX1A
Human Genome Epidemiology (HuGE) Navigator: LMX1A (6 documents)

Export disorders for LMX1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LMX1A gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with LMX1A)

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Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians. (PubMed id 12062816)^{1, 2, 4} Thameem F....Prochazka M. (2002)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13. (PubMed id 7698771)^{1, 3} German M.S....Bell G.I. (1994)
Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue- specific expression and linkage mapping on chromosome 9. (PubMed id 9441763)^{1, 9} Iannotti C.A.... Permutt M.A. (1997)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Hypermethylation-mediated reduction of LMX1A expressi on in gastric cancer. (PubMed id 21159062)¹ Dong W....Wu Y. (2011)
Preliminary evidence that allelic variation in the LM X1A gene influences training-related working memory improvement. (PubMed id 21435346)¹ Bellander M....BAockman L. (2011)
Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. (PubMed id 21177773)¹ Moyer A.M....Weinshilboum R.M. (2011)
Transcription factor-induced lineage selection of stem -cell-derived neural progenitor cells. (PubMed id 21624811)¹ Panman L....Perlmann T. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4009	HGNC: 6653	AceView: LMX1A	Ensembl:ENSG00000162761	euGenes: HUgn4009
ECgene: LMX1A	H-InvDB: LMX1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LMX1A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LMX1A gene
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Patent Information for LMX1A gene:
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LIM homeobox transcription factor 1, alpha

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LIM homeobox transcription factor 1, alpha

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