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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LMX1A Gene

protein-coding   GIFtS: 54
GCID: GC01M165171

LIM Homeobox Transcription Factor 1, Alpha


(Previous symbol: LMX1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LIM Homeobox Transcription Factor 1, Alpha1 2     LIM Homeobox Transcription Factor 1-Alpha2
LMX11 2 5     LMX-1.13
LIM/Homeobox Protein 1.12 3     LIM/Homeobox Protein LMX1A3
LMX1.12     

External Ids:    HGNC: 66531   Entrez Gene: 40092   Ensembl: ENSG000001627617   OMIM: 6002985   UniProtKB: Q8TE123   

Export aliases for LMX1A gene to outside databases

Previous GC identifers: GC01U990100 GC01M160823 GC01M161868 GC01M162360 GC01M162358 GC01M161902 GC01M163437 GC01M136417


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LMX1A Gene:
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor
that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development
of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk
of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. (provided by
RefSeq, Feb 2012)

GeneCards Summary for LMX1A Gene: 
LMX1A (LIM homeobox transcription factor 1, alpha) is a protein-coding gene. Diseases associated with LMX1A include ovarian mucinous cystadenocarcinoma, and mucinous cystadenocarcinoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12
Function: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin
gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in
the CNS and developing vertebrae (By similarity)

Gene Wiki entry for LMX1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LMX1A gene promoter:
         TBP   NRSF form 1   Nkx2-5   Tal-1beta   NRSF form 2   AREB6   CP2   IRF-7A   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMX1A promoter sequence
   Search SABiosciences Chromatin IP Primers for LMX1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LMX1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.1   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q24.1

LMX1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMX1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M165171:  view genomic region     (about GC identifiers)

Start:
165,171,104 bp from pter      End:
165,325,952 bp from pter
Size:
154,849 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12 (See protein sequence)
Recommended Name: LIM homeobox transcription factor 1-alpha  
Size: 382 amino acids; 42747 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B3KXP6 Q0VDB5 Q5VWG4 Q8TE11
Alternative splicing: 2 isoforms:  Q8TE12-1   Q8TE12-2   

Explore the universe of human proteins at neXtProt for LMX1A: NX_Q8TE12

Explore proteomics data for LMX1A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TE12

  • LMX1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LMX1A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001167540.1  NP_796372.1  

    ENSEMBL proteins: 
     ENSP00000340226   ENSP00000294816   ENSP00000356868  

    Human Recombinant Protein Products for LMX1A: 
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    Novus Biologicals LMX1A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    LMX1A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LIM: Homeoboxes / LIM class

    4 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q8TE12

    ProtoNet protein and cluster: Q8TE12

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    LMX1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMX1A_HUMAN, Q8TE12
    Function: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin
    gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in
    the CNS and developing vertebrae (By similarity)

         Genatlas biochemistry entry for LMX1A:
    transcriptional regulator of insulin gene,with the LIM-homeo domain (lmx-1),expressed in pancreatic
    islets,expressed in limb mesenchyme through WNT7A induction,involved in dorsoventral polarity of vertebrate limb
    (dorsal differentiation)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    LMX1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LMX1A:
     Decreased viability of wild-ty 

         14 MGI mutant phenotypes (inferred from 18 alleles(MGI details for Lmx1a):
     behavior/neurological  cellular  craniofacial  embryogenesis  growth/size 
     hearing/vestibular/ear  integument  limbs/digits/tail  mortality/aging  nervous system 
     no phenotypic analysis  pigmentation  reproductive system  skeleton 

    LMX1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lmx1atm1.1Tpe for LMX1A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LMX1A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMX1A 
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    SwitchGear 3'UTR luciferase reporter plasmidLMX1A 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LMX1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for LMX1A (Q8TE123 ENSP000002948164) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ISL1P613713, ENSP000002306584I2D: score=2 STRING: ENSP00000230658
    LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
    LHX3Q9UBR43, ENSP000003608114I2D: score=1 STRING: ENSP00000360811
    TCF3P159233, ENSP000002629654I2D: score=1 STRING: ENSP00000262965
    BMPR2Q138733, ENSP000003637084I2D: score=2 STRING: ENSP00000363708
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007411axon guidance IEA--
    GO:0007417central nervous system development ----

    LMX1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LMX1A gene (4 alternative transcripts): 
    NM_001033507.1  NM_177399.2  NM_001174069.1  NM_177398.3  

    Unigene Cluster for LMX1A:

    LIM homeobox transcription factor 1, alpha
    Hs.667312  [show with all ESTs]
    Unigene Representative Sequence: NM_177398
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342310(uc021pdy.1 uc001gcw.2 uc021pdz.1) ENST00000294816(uc001gcz.2)
    ENST00000489443 ENST00000367893

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    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate LMX1A (see all 91):
    hsa-miR-548j hsa-miR-520e hsa-miR-1224-3p hsa-miR-1258 hsa-miR-374a hsa-miR-519a hsa-miR-342-3p hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidLMX1A 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for LMX1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LMX1A
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMX1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMX1A
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    Additional mRNA sequence: 

    AK122800.1 AK127724.1 BC066353.1 BC119743.1 BC119744.1 

    6 DOTS entries:

    DT.91848407  DT.102820696  DT.100703604  DT.101980449  DT.97785790  DT.75100467 

    9 AceView cDNA sequences:

    NM_177399 AK127724 BM720500 BM678780 NM_177398 AK122800 BC066353 AW117277 
    BG722259 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LMX1A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -                             -     -                 -               
    SP2:                                      -     -                 -               
    SP3:                                                                              


    ECgene alternative splicing isoforms for LMX1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LMX1A expression in normal human tissues (normalized intensities)      LMX1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCCTTATG
    LMX1A Expression
    About this image


    LMX1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Dopaminergic Progenitor Cells Substantia Nigra pars Compacta
             Midbrain tegmentum
             N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
             brain/midbrain/lateral wall   
     
     Neural Tube (Nervous System)    fully expand to see all 8 entries
             Meso-diencephalic Dopaminergic Precursor Cells Mesencephalic Ventricular Zone
             Metencephalon
             brain/midbrain/lateral wall   
     
     Testis (Reproductive System)
             sperm   
     
     Bone (Muscoskeletal System)
             sensory organ/ear/inner ear   
     
     Inner Cell Mass (Early Embryonic Tissues)
             440A-3

    See LMX1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LMX1A

    SOURCE GeneReport for Unigene cluster: Hs.667312

    UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12
    Tissue specificity: Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis.
    Relatively highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis

        SABiosciences Expression via Pathway-Focused PCR Array including LMX1A: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMX1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LMX1A gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lmx1a1 , 5 LIM homeobox transcription factor 1 alpha1, 5 90.92(n)1
    97.12(a)1
      1 (75.08 cM)5
    1106481  NM_033652.51  NP_387501.11 
     1676892395 
    chicken
    (Gallus gallus)
    Aves LMX1A1 LIM homeobox transcription factor 1, alpha 80.96(n)
    87.11(a)
      777133  XM_003641657.1  XP_003641705.1 
    lizard
    (Anolis carolinensis)
    Reptilia LMX1A6
    --
    --
    77(a)
    59(a)
    1 ↔ 1
    possible ortholog
    GL344236.1(23522-45390)
    GL343198.1(4362241-4461707)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.124642 Xenopus laevis LIM homeobox protein 1b (Lmx1b) mRNA, more 73.61(n)    AF414086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.139642 Transcribed sequence with weak similarity to protein more 81.1(n)    BI843115.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG43286
    CG321056
    --
    25(a)
    23(a)
    possible ortholog
    1 ↔ many
    3L(12284056-12289223)
    3L(12322332-12329001)
    worm
    (Caenorhabditis elegans)
    Secernentea lim-66
    Protein LIM-6, isoform b
    32(a)
    1 → many
    X(1074224-1079339)


    ENSEMBL Gene Tree for LMX1A (if available)
    TreeFam Gene Tree for LMX1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LMX1A gene
    ISL12  LMO22  LHX22  LHX92  LMX1B2  LHX52  LMO12  LHX62  
    LMO42  LHX12  LMO32  LHX32  LHX42  LHX82  ISL22  
    11 SIMAP similar genes for LMX1A using alignment to 2 protein entries:     LMX1A_HUMAN (see all proteins):
    LMX1B    LMO3    LMO4    LMO2    ISL1    ISL2
    LHX1    LHX4    LHX5    LHX3    LHX8

    LMX1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3208 SNPs in LMX1A are shown (see all 3208)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30380761,2
    C--136438058(+) acaca-/CA/   
      CACACA
    cgcac
    4 -- int1 cds12NA 4
    rs666870721,2
    C--136461003(+) AAAAA-/A/AA  
            
    TCATC
    2 -- int11NA 2
    rs1866611151,2
    --165170712(+) TCAGGA/GAGCCA 2 -- int10--------
    rs1925885751,2
    --165170713(+) CAGGGA/GGCCAC 2 -- int10--------
    rs1450065221,2
    --165170718(+) AGCCAC/TGATCT 2 -- int10--------
    rs120237091,2
    C,F,A,H--165170720(+) CCACGA/GTCTGC 2 -- int123Minor allele frequency- G:0.28NS EA NA WA 2554
    rs1847374441,2
    --165170729(+) GCTGCC/TTGGCT 2 -- int10--------
    rs1491033761,2
    C--165170771(+) CCTGCA/CTGAGA 2 -- int10--------
    rs1431978831,2
    --165170822(+) CAAATA/GTTCCC 2 -- int10--------
    rs730272621,2
    C,F--165170835(+) ATCACG/ATATCA 2 -- int12Minor allele frequency- A:0.14WA 120

    HapMap Linkage Disequilibrium report for LMX1A (165171104 - 165325952 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LMX1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719084CNV Deletion23290073
    esv1005410CNV Deletion20482838
    esv2678124CNV Deletion23128226
    esv1310421CNV Deletion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600298    OMIM disorders: --

    13 diseases for LMX1A:    About MalaCards
    ovarian mucinous cystadenocarcinoma    mucinous cystadenocarcinoma    cystadenocarcinoma    parkinson's disease
    essential hypertension    hypertension    t-cell leukemia    cervical cancer
    cervicitis    gastric cancer    neuronitis    pancreatitis
    leukemia

    2 diseases from the University of Copenhagen DISEASES database for LMX1A:
    Ovarian mucinous cystadenocarcinoma     Parkinson's disease

    LMX1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): LMX1A
    Human Genome Epidemiology (HuGE) Navigator: LMX1A (6 documents)

    Export disorders for LMX1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LMX1A gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with LMX1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians. (PubMed id 12062816)1, 2, 4 Thameem F....Prochazka M. (2002)
    2. Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. (PubMed id 21177773)1, 4 Moyer A.M....Weinshilboum R.M. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Preliminary evidence that polymorphisms in dopamine-r elated transcription factors LMX1A, LMX1B and PITX3 are associated with schizop hrenia. (PubMed id 20570600)1, 4 Bergman O....Eriksson E. (2010)
    5. Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease? (PubMed id 19189040)1, 4 Bergman O....Nissbrandt H. (2009)
    6. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (2009)
    7. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (2009)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13. (PubMed id 7698771)1, 3 German M.S....Bell G.I. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4009 HGNC: 6653 AceView: LMX1A Ensembl:ENSG00000162761 euGenes: HUgn4009
    ECgene: LMX1A H-InvDB: LMX1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LMX1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LMX1A gene:
    Search GeneIP for patents involving LMX1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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