Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LMX1A Gene

protein-coding   GIFtS: 50
GCID: GC01M165171

LIM Homeobox Transcription Factor 1, Alpha


(Previous symbol: LMX1)
  See LMX1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
LIM Homeobox Transcription Factor 1, Alpha1 2     LIM Homeobox Transcription Factor 1-Alpha2
LMX11 2 5     LMX-1.13
LIM/Homeobox Protein 1.12 3     LIM/Homeobox Protein LMX1A3
LMX1.12     

External Ids:    HGNC: 66531   Entrez Gene: 40092   Ensembl: ENSG000001627617   OMIM: 6002985   UniProtKB: Q8TE123   

Export aliases for LMX1A gene to outside databases

Previous GC identifers: GC01U990100 GC01M160823 GC01M161868 GC01M162360 GC01M162358 GC01M161902 GC01M163437 GC01M136417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LMX1A Gene:
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor
that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development
of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk
of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. (provided by
RefSeq, Feb 2012)

GeneCards Summary for LMX1A Gene:
LMX1A (LIM homeobox transcription factor 1, alpha) is a protein-coding gene. Diseases associated with LMX1A include ovarian mucinous cystadenocarcinoma, and mucinous cystadenocarcinoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12
Function: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin
gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in
the CNS and developing vertebrae (By similarity)

Gene Wiki entry for LMX1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the LMX1A gene promoter:
         TBP   NRSF form 1   Nkx2-5   Tal-1beta   NRSF form 2   AREB6   CP2   IRF-7A   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLMX1A promoter sequence
   Search Chromatin IP Primers for LMX1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMX1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.1   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q24.1

LMX1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LMX1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M165171:  view genomic region     (about GC identifiers)

Start:
165,171,104 bp from pter      End:
165,325,952 bp from pter
Size:
154,849 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12 (See protein sequence)
Recommended Name: LIM homeobox transcription factor 1-alpha  
Size: 382 amino acids; 42747 Da
Secondary accessions: B3KXP6 Q0VDB5 Q5VWG4 Q8TE11
Alternative splicing: 2 isoforms:  Q8TE12-1   Q8TE12-2   

Explore the universe of human proteins at neXtProt for LMX1A: NX_Q8TE12

Explore proteomics data for LMX1A at MOPED


See LMX1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001167540.1  NP_796372.1  

ENSEMBL proteins: 
 ENSP00000340226   ENSP00000294816   ENSP00000356868  

LMX1A Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for LMX1A
OriGene Custom MassSpec
OriGene Custom Protein Services for LMX1A
GenScript Custom Purified and Recombinant Proteins Services for LMX1A
Novus Biologicals LMX1A Protein
Novus Biologicals LMX1A Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for LMX1A 

LMX1A Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for LMX1A
OriGene Custom Antibody Services for LMX1A
Novus Biologicals LMX1A Antibodies
Abcam antibodies for LMX1A
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for LMX1A
LSBio Antibodies in human, mouse, rat for LMX1A

LMX1A Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for LMX1A
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for LMX1A
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for LMX1A 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
LIM: Homeoboxes / LIM class

4 InterPro protein domains:
 IPR001781 Znf_LIM
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q8TE12

ProtoNet protein and cluster: Q8TE12

1 Blocks protein domain: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12
Similarity: Contains 1 homeobox DNA-binding domain
Similarity: Contains 2 LIM zinc-binding domains


Find genes that share domains with LMX1A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: LMX1A_HUMAN, Q8TE12
Function: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin
gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in
the CNS and developing vertebrae (By similarity)

     Genatlas biochemistry entry for LMX1A:
transcriptional regulator of insulin gene,with the LIM-homeo domain (lmx-1),expressed in pancreatic
islets,expressed in limb mesenchyme through WNT7A induction,involved in dorsoventral polarity of vertebrate limb
(dorsal differentiation)

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0008270zinc ion binding IEA--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with LMX1A           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for LMX1A:
 Decreased viability of wild-ty 

     14 MGI mutant phenotypes (inferred from 18 alleles(MGI details for Lmx1a):
 behavior/neurological  cellular  craniofacial  embryogenesis  growth/size/body 
 hearing/vestibular/ear  integument  limbs/digits/tail  mortality/aging  nervous system 
 no phenotypic analysis  pigmentation  reproductive system  skeleton 

Find genes that share phenotypes with LMX1A           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Lmx1atm1.1Tpe for LMX1A

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMX1A
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMX1A

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LMX1A
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LMX1A

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat LMX1A using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LMX1A (see all 91):
hsa-miR-548j hsa-miR-520e hsa-miR-1224-3p hsa-miR-1258 hsa-miR-374a hsa-miR-519a hsa-miR-342-3p hsa-miR-502-3p
SwitchGear 3'UTR luciferase reporter plasmidLMX1A 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for LMX1A
Predesigned siRNA for gene silencing in human, mouse, rat LMX1A

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for LMX1A

Clone
Products:
     
OriGene clones in human, mouse for LMX1A (see all 11)
OriGene ORF clones in mouse, rat for LMX1A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): LMX1A (NM_177398)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMX1A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMX1A

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for LMX1A
Browse ESI BIO Cell Lines and PureStem Progenitors for LMX1A 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMX1A


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
LMX1A_HUMAN, Q8TE12: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
golgi apparatus2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with LMX1A           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Pathway & Disease-focused RT2 Profiler PCR Array including LMX1A: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for LMX1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for LMX1A (Q8TE123 ENSP000002948164) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
ISL1P613713, ENSP000002306584I2D: score=2 STRING: ENSP00000230658
LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
LDB2O436793, ENSP000003067724I2D: score=1 STRING: ENSP00000306772
LHX3Q9UBR43, ENSP000003608114I2D: score=1 STRING: ENSP00000360811
TCF3P159233, ENSP000002629654I2D: score=1 STRING: ENSP00000262965
About this table

Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001558regulation of cell growth IEA--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007411axon guidance IEA--
GO:0007417central nervous system development ----

Find genes that share ontologies with LMX1A           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for LMX1A



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for LMX1A gene (4 alternative transcripts): 
NM_001033507.1  NM_177399.2  NM_001174069.1  NM_177398.3  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000342310(uc021pdy.1 uc001gcw.2 uc021pdz.1) ENST00000294816(uc001gcz.2)
ENST00000489443 ENST00000367893
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat LMX1A using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate LMX1A (see all 91):
hsa-miR-548j hsa-miR-520e hsa-miR-1224-3p hsa-miR-1258 hsa-miR-374a hsa-miR-519a hsa-miR-342-3p hsa-miR-502-3p
SwitchGear 3'UTR luciferase reporter plasmidLMX1A 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for LMX1A
Predesigned siRNA for gene silencing in human, mouse, rat LMX1A
Clone
Products:
     
OriGene clones in human, mouse for LMX1A (see all 11)
OriGene ORF clones in mouse, rat for LMX1A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): LMX1A (NM_177398)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LMX1A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMX1A
Primer
Products:
    
OriGene qPCR primer pairs and template standards for LMX1A
OriGene qSTAR qPCR primer pairs in human, mouse for LMX1A
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMX1A
  QuantiTect SYBR Green Assays in human, mouse, rat LMX1A
  QuantiFast Probe-based Assays in human, mouse, rat LMX1A

9 AceView cDNA sequences:

AK127724 NM_177398 BM720500 NM_177399 BM678780 AK122800 BC066353 BG722259 
AW117277 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for LMX1A    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:        -                             -     -                 -               
SP2:                                      -     -                 -               
SP3:                                                                              


ECgene alternative splicing isoforms for LMX1A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

LMX1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCCCCTTATG
LMX1A Expression
About this image


LMX1A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 11) fully expand
 
 Brain (Nervous System)    fully expand to see all 15 entries
         Dopaminergic Progenitor Cells Substantia Nigra pars Compacta
         Midbrain tegmentum
         N2/LSB/S/F8/CHIR-induced cells
 
 Neurons
         Dopaminergic Progenitor Cells Substantia Nigra pars Compacta
         Midbrain dopaminergic-like neurons
 
 Neural Tube (Nervous System)    fully expand to see all 8 entries
         Meso-diencephalic Dopaminergic Precursor Cells Diencephalic Ventricular Zone
         Mesencephalic Floor Plate
         Floor plate-like cells
 
 Pancreas (Endocrine System)
         Mature Beta Cells Islets of Langerhans
 
 Dopaminergic Neurons (Nervous System)    fully expand to see all 3 entries
         Dopaminergic neuron-like cells
LMX1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

LMX1A Protein Expression

UniProtKB/Swiss-Prot: LMX1A_HUMAN, Q8TE12
Tissue specificity: Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis.
Relatively highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis

    Pathway & Disease-focused RT2 Profiler PCR Array including LMX1A: 
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for LMX1A
OriGene qSTAR qPCR primer pairs in human, mouse for LMX1A
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMX1A
QuantiTect SYBR Green Assays in human, mouse, rat LMX1A
QuantiFast Probe-based Assays in human, mouse, rat LMX1A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMX1A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for LMX1A gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lmx1a1 , 5 LIM homeobox transcription factor 1 alpha1, 5 90.92(n)1
97.12(a)1
  1 (75.08 cM)5
1106481  NM_033652.51  NP_387501.11 
 1676892395 
chicken
(Gallus gallus)
Aves LMX1A1 LIM homeobox transcription factor 1, alpha 80.96(n)
87.11(a)
  777133  NM_001257388.1  NP_001244317.1 
lizard
(Anolis carolinensis)
Reptilia LMX1A6
LIM homeobox transcription factor 1, alpha
77(a)
1 ↔ 1
GL344236.1(23522-45390)
African clawed frog
(Xenopus laevis)
Amphibia Xl.124642 Xenopus laevis LIM homeobox protein 1b (Lmx1b) mRNA, more 73.61(n)    AF414086.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.139642 Transcribed sequence with weak similarity to protein more 81.1(n)    BI843115.1 
fruit fly
(Drosophila melanogaster)
Insecta CG43286
CG321056
--
26(a)
25(a)
many ↔ many
many ↔ many
3L(12284056-12289223)
3L(12322332-12329001)
worm
(Caenorhabditis elegans)
Secernentea lim-66
Protein LIM-6, isoform b
37(a)
1 → many
X(1074224-1079339) WBGene00002988


ENSEMBL Gene Tree for LMX1A (if available)
TreeFam Gene Tree for LMX1A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for LMX1A gene
ISL12  LHX22  LHX92  LMX1B2  LHX52  LHX62  LHX12  LHX42  
LHX32  LHX82  ISL22  
11 SIMAP similar genes for LMX1A using alignment to 2 protein entries:     LMX1A_HUMAN (see all proteins):
LMX1B    LMO3    LMO4    LMO2    ISL1    ISL2
LHX1    LHX4    LHX5    LHX3    LHX8

Find genes that share paralogs with LMX1A           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for LMX1A (see all 3208)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs30380761,2
C--136438058(+) acaca-/CA/   
  CACACA
cgcac
4 -- int1 cds12NA 4
rs666870721,2
C--136461003(+) AAAAA-/A/AA  
        
TCATC
2 -- int11NA 2
rs1866611151,2
--165170712(+) TCAGGA/GAGCCA 2 -- int10--------
rs1925885751,2
--165170713(+) CAGGGA/GGCCAC 2 -- int10--------
rs1450065221,2
--165170718(+) AGCCAC/TGATCT 2 -- int10--------
rs120237091,2
C,F,A,H--165170720(+) CCACGA/GTCTGC 2 -- int123Minor allele frequency- G:0.28NS EA NA WA 2554
rs1847374441,2
--165170729(+) GCTGCC/TTGGCT 2 -- int10--------
rs1491033761,2
C--165170771(+) CCTGCA/CTGAGA 2 -- int10--------
rs1431978831,2
--165170822(+) CAAATA/GTTCCC 2 -- int10--------
rs730272621,2
C,F--165170835(+) ATCACG/ATATCA 2 -- int12Minor allele frequency- A:0.14WA 120

HapMap Linkage Disequilibrium report for LMX1A (165171104 - 165325952 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for LMX1A:    About this table    
Variant IDTypeSubtypePubMed ID
esv2719084CNV Deletion23290073
esv1005410CNV Deletion20482838
esv2678124CNV Deletion23128226
esv1310421CNV Deletion17803354

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing LMX1A
DNA2.0 Custom Variant and Variant Library Synthesis for LMX1A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 600298    OMIM disorders: --

2 diseases for LMX1A:    
About MalaCards
ovarian mucinous cystadenocarcinoma    mucinous cystadenocarcinoma

2 diseases from the University of Copenhagen DISEASES database for LMX1A:
Ovarian mucinous cystadenocarcinoma     Parkinson's disease

Find genes that share disorders with LMX1A           About GenesLikeMe

Genetic Association Database (GAD): LMX1A
Human Genome Epidemiology (HuGE) Navigator: LMX1A (6 documents)

Export disorders for LMX1A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for LMX1A gene, integrated from 10 sources (see all 37):
(articles sorted by number of sources associating them with LMX1A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians. (PubMed id 12062816)1, 2, 4 Thameem F....Prochazka M. (Gene 2002)
  2. Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study. (PubMed id 21177773)1, 4 Moyer A.M....Weinshilboum R.M. (Toxicol. Sci. 2011)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  4. Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia. (PubMed id 20570600)1, 4 Bergman O....Eriksson E. (amp 2010)
  5. Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease? (PubMed id 19189040)1, 4 Bergman O....Nissbrandt H. (J Neural Transm 2009)
  6. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
  7. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PubMed id 19064610)1, 4 Cheung C.L....Kung A.W. (Hum. Mol. Genet. 2009)
  8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  10. Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13. (PubMed id 7698771)1, 3 German M.S....Bell G.I. (Genomics 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 4009 HGNC: 6653 AceView: LMX1A Ensembl:ENSG00000162761 euGenes: HUgn4009
ECgene: LMX1A H-InvDB: LMX1A

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for LMX1A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for LMX1A gene:
Search GeneIP for patents involving LMX1A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for LMX1A   OriGene RNAi products in human, mouse, rat for LMX1A  
 OriGene qPCR primer pairs and template standards for LMX1A   OriGene Protein Over-expression Lysate for LMX1A  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for LMX1A  
 OriGene qSTAR qPCR primer pairs in human, mouse for LMX1A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for LMX1A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for LMX1A   OriGene Custom Protein Services for LMX1A  

 
 
 Block miRNA regulation of human, mouse, rat LMX1A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LMX1A
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LMX1A Predesigned siRNA for gene silencing in human, mouse, rat LMX1A
 QuantiFast Probe-based Assays in human, mouse, rat LMX1A QuantiTect SYBR Green Assays in human, mouse, rat LMX1A
 PCR Arrays including human, mouse, rat LMX1A Search Chromatin IP Primers for LMX1A
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LMX1A  GeneGlobe Interaction Network for LMX1A
 Regulatory tfbs in LMX1A promoter
 GenScript Custom Purified and Recombinant Proteins Services for LMX1A GenScript cDNA clones with any tag delivered in your preferred vector for LMX1A
 GenScript Custom Assay Services for LMX1A GenScript Custom overexpressing Cell Line Services for LMX1A
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for LMX1A
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 LMX1A antibodies
 LMX1A proteins
 LMX1A lysates
 Antibodies for LMX1A
 See all of Abcam's Antibodies, Kits and Proteins for LMX1A
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for LMX1A
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LMX1A
 SwitchGear 3'UTR luciferase reporter plasmids for LMX1A
 SwitchGear Promoter luciferase reporter plasmids for LMX1A
 ThermoFisher Antibodies for LMX1A
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LMX1A
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LMX1A
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LMX1A
 LSBio Antibodies in human, mouse, rat for LMX1A
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for LMX1A
  Search eBioscience for proteins for LMX1A
  Search eBioscience for elisas for LMX1A
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      LMX1A gene at Home site.
Version: 3.12.202 14 Sep 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4