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Aliases for LMTK3 Gene

Aliases for LMTK3 Gene

  • Lemur Tyrosine Kinase 3 2 3 4 5
  • TYKLM3 3 4
  • Protein Phosphatase 1, Regulatory Subunit 101 3
  • Regulatory Subunit 101 2
  • Protein Phosphatase 1 2
  • EC 2.7.11.1 4
  • PPP1R101 3
  • KIAA1883 4
  • LMR3 3

External Ids for LMTK3 Gene

Previous GeneCards Identifiers for LMTK3 Gene

  • GC19M053680
  • GC19M048988
  • GC19M045368

Summaries for LMTK3 Gene

GeneCards Summary for LMTK3 Gene

LMTK3 (Lemur Tyrosine Kinase 3) is a Protein Coding gene. Among its related pathways are ERK Signaling and Akt Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.

UniProtKB/Swiss-Prot for LMTK3 Gene

  • Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMTK3 Gene

Genomics for LMTK3 Gene

Regulatory Elements for LMTK3 Gene

Promoters for LMTK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LMTK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LMTK3 Gene

Chromosome:
19
Start:
48,485,271 bp from pter
End:
48,513,905 bp from pter
Size:
28,635 bases
Orientation:
Minus strand

Genomic View for LMTK3 Gene

Genes around LMTK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMTK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMTK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMTK3 Gene

Proteins for LMTK3 Gene

  • Protein details for LMTK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q04-LMTK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LMTK3
    Protein Accession:
    Q96Q04
    Secondary Accessions:
    • Q4G0U1

    Protein attributes for LMTK3 Gene

    Size:
    1460 amino acids
    Molecular mass:
    153661 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with ESR1 (PubMed:21602804). Interacts with AP-2 complex subunit alpha (By similarity).
    SequenceCaution:
    • Sequence=AAH36690.1; Type=Frameshift; Positions=809; Evidence={ECO:0000305}; Sequence=BAB67776.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for LMTK3 Gene

Proteomics data for LMTK3 Gene at MOPED

Post-translational modifications for LMTK3 Gene

  • Glycosylation at Asn 1081 and Asn 1405
  • Modification sites at PhosphoSitePlus

Other Protein References for LMTK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LMTK3 Gene

Domains & Families for LMTK3 Gene

Suggested Antigen Peptide Sequences for LMTK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96Q04

UniProtKB/Swiss-Prot:

LMTK3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with LMTK3: view

Function for LMTK3 Gene

Molecular function for LMTK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

Enzyme Numbers (IUBMB) for LMTK3 Gene

Gene Ontology (GO) - Molecular Function for LMTK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with LMTK3: view
genes like me logo Genes that share phenotypes with LMTK3: view

Animal Models for LMTK3 Gene

MGI Knock Outs for LMTK3:

Animal Model Products

miRNA for LMTK3 Gene

miRTarBase miRNAs that target LMTK3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LMTK3 Gene

Localization for LMTK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMTK3 Gene

Membrane; Single-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMTK3 Gene COMPARTMENTS Subcellular localization image for LMTK3 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LMTK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0030424 axon IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with LMTK3: view

Pathways & Interactions for LMTK3 Gene

genes like me logo Genes that share pathways with LMTK3: view

Pathways by source for LMTK3 Gene

Interacting Proteins for LMTK3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000270238%0d%0a9606.ENSP00000326031%0d%0a
Selected Interacting proteins: ENSP00000270238 Q96Q04-LMTK3_HUMAN for LMTK3 Gene via STRING I2D MINT

Gene Ontology (GO) - Biological Process for LMTK3 Gene

None

No data available for SIGNOR curated interactions for LMTK3 Gene

Drugs & Compounds for LMTK3 Gene

(2) Drugs for LMTK3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for LMTK3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LMTK3: view

Transcripts for LMTK3 Gene

mRNA/cDNA for LMTK3 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LMTK3 Gene

Lemur tyrosine kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LMTK3 Gene

No ASD Table

Relevant External Links for LMTK3 Gene

GeneLoc Exon Structure for
LMTK3
ECgene alternative splicing isoforms for
LMTK3

Expression for LMTK3 Gene

mRNA expression in normal human tissues for LMTK3 Gene

mRNA differential expression in normal tissues according to GTEx for LMTK3 Gene

This gene is overexpressed in Brain - Cortex (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.1), Brain - Putamen (basal ganglia) (x4.6), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for LMTK3 Gene

This gene is overexpressed in Fetal Brain (30.3), Serum (22.6), and Frontal cortex (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LMTK3 Gene



SOURCE GeneReport for Unigene cluster for LMTK3 Gene Hs.207426

genes like me logo Genes that share expression patterns with LMTK3: view

Protein tissue co-expression partners for LMTK3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LMTK3 Gene

Orthologs for LMTK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LMTK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMTK3 35
  • 91.22 (n)
  • 92.76 (a)
LMTK3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LMTK3 35
  • 92.07 (n)
  • 90.91 (a)
LMTK3 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmtk3 35
  • 86.94 (n)
  • 89.19 (a)
Lmtk3 16
Lmtk3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LMTK3 35
  • 96.69 (n)
  • 95.43 (a)
LMTK3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691056 35
  • 86.82 (n)
  • 88.96 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia LMTK3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMTK3 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmtk3 35
  • 61.47 (n)
  • 64.07 (a)
zebrafish
(Danio rerio)
Actinopterygii LMTK3 36
  • 15 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.46789 35
Species with no ortholog for LMTK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMTK3 Gene

ENSEMBL:
Gene Tree for LMTK3 (if available)
TreeFam:
Gene Tree for LMTK3 (if available)

Paralogs for LMTK3 Gene

Paralogs for LMTK3 Gene

(6) SIMAP similar genes for LMTK3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LMTK3: view

Variants for LMTK3 Gene

Sequence variations from dbSNP and Humsavar for LMTK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1643478 -, - 48,498,371(-) AGAAA(C/G/T)TCCCG reference, missense
rs1799285 -- 48,498,270(-) GGGGA(C/T)CAGAG reference, synonymous-codon
rs1643477 -- 48,504,249(-) GGAGA(A/C/T)GATGT intron-variant
rs1643479 -- 48,489,650(-) cctcc(C/T)gagta intron-variant
rs1320401 -- 48,511,372(-) CAGGG(A/C)CCGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMTK3 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv912219 CNV Loss 21882294
nsv828572 CNV Loss 20364138
nsv912222 CNV Loss 21882294
nsv912223 CNV Loss 21882294
nsv518578 CNV Loss 19592680
nsv817853 CNV Loss 17921354

Variation tolerance for LMTK3 Gene

Gene Damage Index Score: 2.92; 49.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMTK3 Gene

HapMap Linkage Disequilibrium report
LMTK3
Human Gene Mutation Database (HGMD)
LMTK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMTK3 Gene

Disorders for LMTK3 Gene

Relevant External Links for LMTK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMTK3

No disorders were found for LMTK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMTK3 Gene

Publications for LMTK3 Gene

  1. Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. (PMID: 21602804) Giamas G. … Stebbing J. (Nat. Med. 2011) 3 4 67
  2. Lemur tyrosine kinase-3 is a significant prognostic marker for patients with colorectal cancer. (PMID: 24695631) Shi H. … Jiang J. (Int J Clin Exp Pathol 2014) 3
  3. High expression of LMTK3 is an independent factor indicating a poor prognosis in estrogen receptor I+-positive breast cancer patients. (PMID: 25163465) Asano T. … Toyama T. (Jpn. J. Clin. Oncol. 2014) 3
  4. Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening. (PMID: 25495526) Zhou Z. … Liu J. (BMC Cancer 2014) 3
  5. The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin I^a88. (PMID: 24939894) Xu Y. … Giamas G. (Sci Signal 2014) 3

Products for LMTK3 Gene

Sources for LMTK3 Gene

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