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Aliases for LMTK3 Gene

Aliases for LMTK3 Gene

  • Lemur Tyrosine Kinase 3 2 3 4 5
  • Protein Phosphatase 1, Regulatory Subunit 101 2 3
  • TYKLM3 3 4
  • Serine/Threonine-Protein Kinase LMTK3 3
  • EC 2.7.11.1 4
  • PPP1R101 3
  • KIAA1883 4
  • LMR3 3

External Ids for LMTK3 Gene

Previous GeneCards Identifiers for LMTK3 Gene

  • GC19M053680
  • GC19M048988
  • GC19M045368

Summaries for LMTK3 Gene

GeneCards Summary for LMTK3 Gene

LMTK3 (Lemur Tyrosine Kinase 3) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AATK.

UniProtKB/Swiss-Prot for LMTK3 Gene

  • Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMTK3 Gene

Genomics for LMTK3 Gene

Regulatory Elements for LMTK3 Gene

Enhancers for LMTK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F048462 0.5 ENCODE 11.6 +51.4 51407 0.2 HDGF ATF1 ARNT CREB3L1 SIN3A DMAP1 ZNF2 ETS1 YY1 ZNF766 ENSG00000269321 GLTSCR1 TEAD2 GRWD1 EHD2 LOC105372430 ELSPBP1 NTF6B NTF6A TPRX2P
GH19F048283 0.6 ENCODE 10.9 +229.5 229523 2.0 HDGF ATF1 CBX3 TBL1XR1 CREB3L1 SIN3A ARID4B NFXL1 ZNF2 ZSCAN9 CCDC114 SYNGR4 TMEM143 LMTK3 IZUMO1 GRIN2D SPHK2 GC19P048288 LOC105372429
GH19F047963 0.6 ENCODE 10.2 +550.6 550557 0.2 CTCF PKNOX1 ZNF384 ZIC2 ZNF2 RAD21 ZEB1 HIC1 ZNF335 GATA3 PLA2G4C BSPH1 ELSPBP1 CABP5 SULT2A1 LMTK3 SYNGR4 TMEM143 SNAR-C1 GC19M047959
GH19F048091 0.2 ENCODE 9.4 +422.4 422367 0.2 ZNF121 ZFHX2 JUND POLR3A BHLHE40 FOS TCF7L2 CABP5 ELSPBP1 BSPH1 NAPA SULT2A1 LMTK3 PLA2G4C PLA2G4C-AS1
GH19F048083 0.3 FANTOM5 2.2 +430.0 429978 0.1 PLA2G4C ELSPBP1 BSPH1 LMTK3 PLA2G4C-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LMTK3 on UCSC Golden Path with GeneCards custom track

Promoters for LMTK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000142765 205 1001 ARID4B SIN3A ZNF2 ETS1 GLIS2 ELK1 ZNF143 SP3 SMARCB1 GLIS1

Genomic Location for LMTK3 Gene

Chromosome:
19
Start:
48,485,271 bp from pter
End:
48,513,905 bp from pter
Size:
28,635 bases
Orientation:
Minus strand

Genomic View for LMTK3 Gene

Genes around LMTK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMTK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMTK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMTK3 Gene

Proteins for LMTK3 Gene

  • Protein details for LMTK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q04-LMTK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LMTK3
    Protein Accession:
    Q96Q04
    Secondary Accessions:
    • Q4G0U1

    Protein attributes for LMTK3 Gene

    Size:
    1460 amino acids
    Molecular mass:
    153661 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with ESR1 (PubMed:21602804). Interacts with AP-2 complex subunit alpha (By similarity).
    SequenceCaution:
    • Sequence=AAH36690.1; Type=Frameshift; Positions=809; Evidence={ECO:0000305}; Sequence=BAB67776.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for LMTK3 Gene

Post-translational modifications for LMTK3 Gene

  • Glycosylation at Asn 1081 and Asn 1405
  • Modification sites at PhosphoSitePlus

Other Protein References for LMTK3 Gene

No data available for DME Specific Peptides for LMTK3 Gene

Domains & Families for LMTK3 Gene

Suggested Antigen Peptide Sequences for LMTK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96Q04

UniProtKB/Swiss-Prot:

LMTK3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with LMTK3: view

Function for LMTK3 Gene

Molecular function for LMTK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).

Enzyme Numbers (IUBMB) for LMTK3 Gene

Gene Ontology (GO) - Molecular Function for LMTK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003674 molecular_function ND --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with LMTK3: view
genes like me logo Genes that share phenotypes with LMTK3: view

Animal Models for LMTK3 Gene

MGI Knock Outs for LMTK3:

Animal Model Products

miRNA for LMTK3 Gene

miRTarBase miRNAs that target LMTK3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LMTK3 Gene

Localization for LMTK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LMTK3 Gene

Membrane; Single-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Note=Punctate pattern in cell projections.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMTK3 Gene COMPARTMENTS Subcellular localization image for LMTK3 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LMTK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005575 cellular_component ND --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LMTK3: view

Pathways & Interactions for LMTK3 Gene

genes like me logo Genes that share pathways with LMTK3: view

Interacting Proteins for LMTK3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000270238%0d%0a9606.ENSP00000326031%0d%0a
Selected Interacting proteins: Q96Q04-LMTK3_HUMAN ENSP00000270238 for LMTK3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for LMTK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with LMTK3: view

No data available for SIGNOR curated interactions for LMTK3 Gene

Drugs & Compounds for LMTK3 Gene

(2) Drugs for LMTK3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for LMTK3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LMTK3: view

Transcripts for LMTK3 Gene

mRNA/cDNA for LMTK3 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LMTK3 Gene

Lemur tyrosine kinase 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMTK3 Gene

No ASD Table

Relevant External Links for LMTK3 Gene

GeneLoc Exon Structure for
LMTK3
ECgene alternative splicing isoforms for
LMTK3

Expression for LMTK3 Gene

mRNA expression in normal human tissues for LMTK3 Gene

mRNA differential expression in normal tissues according to GTEx for LMTK3 Gene

This gene is overexpressed in Brain - Cortex (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.1), Brain - Putamen (basal ganglia) (x4.6), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for LMTK3 Gene

This gene is overexpressed in Fetal Brain (30.3), Serum (22.6), and Frontal cortex (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LMTK3 Gene



Protein tissue co-expression partners for LMTK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LMTK3 Gene:

LMTK3

SOURCE GeneReport for Unigene cluster for LMTK3 Gene:

Hs.207426
genes like me logo Genes that share expression patterns with LMTK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LMTK3 Gene

Orthologs for LMTK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LMTK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LMTK3 34 35
  • 96.69 (n)
dog
(Canis familiaris)
Mammalia LMTK3 34 35
  • 92.07 (n)
cow
(Bos Taurus)
Mammalia LMTK3 34 35
  • 91.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LMTK3 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmtk3 34 16 35
  • 86.94 (n)
rat
(Rattus norvegicus)
Mammalia LOC691056 34
  • 86.82 (n)
lizard
(Anolis carolinensis)
Reptilia LMTK3 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmtk3 34
  • 61.47 (n)
zebrafish
(Danio rerio)
Actinopterygii LMTK3 35
  • 15 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.46789 34
Species where no ortholog for LMTK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LMTK3 Gene

ENSEMBL:
Gene Tree for LMTK3 (if available)
TreeFam:
Gene Tree for LMTK3 (if available)

Paralogs for LMTK3 Gene

Paralogs for LMTK3 Gene

(6) SIMAP similar genes for LMTK3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LMTK3: view

Variants for LMTK3 Gene

Sequence variations from dbSNP and Humsavar for LMTK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401474 -- 48,495,745(+) GGACC(C/T)AGCCA intron-variant
rs10408497 -- 48,496,593(+) ccacc(A/G)tgccc intron-variant
rs10409417 -- 48,502,194(+) ccctt(C/T)tcctc intron-variant
rs10410083 -- 48,497,251(+) agcca(C/G)gatgt intron-variant
rs10415669 -- 48,502,674(+) CTGGG(C/T)AGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMTK3 Gene

Variant ID Type Subtype PubMed ID
nsv1057580 CNV gain 25217958
nsv518578 CNV loss 19592680
nsv817853 CNV loss 17921354
nsv828572 CNV loss 20364138
nsv9739 CNV gain+loss 18304495

Variation tolerance for LMTK3 Gene

Gene Damage Index Score: 2.92; 49.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMTK3 Gene

Human Gene Mutation Database (HGMD)
LMTK3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LMTK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMTK3 Gene

Disorders for LMTK3 Gene

Relevant External Links for LMTK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMTK3

No disorders were found for LMTK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMTK3 Gene

Publications for LMTK3 Gene

  1. Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. (PMID: 21602804) Giamas G. … Stebbing J. (Nat. Med. 2011) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64
  4. LMTK3 escapes tumour suppressor miRNAs via sequestration of DDX5. (PMID: 26739063) Jacob J. … Giamas G. (Cancer Lett. 2016) 3 64
  5. Serum lemur tyrosine kinase-3: a novel biomarker for screening primary non-small cell lung cancer and predicting cancer progression. (PMID: 25755755) Zhang K. … Wang Z. (Int J Clin Exp Pathol 2015) 3 64

Products for LMTK3 Gene

Sources for LMTK3 Gene

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