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Aliases for LMO7 Gene

Aliases for LMO7 Gene

  • LIM Domain 7 2 3
  • F-Box Only Protein 20 2 3 4
  • FBXO20 3 4
  • FBX20 3 4
  • LMO-7 3 4
  • LOMP 3 4
  • Zinc-Finger Domain-Containing Protein 3
  • LIM Domain Only 7 Protein 3
  • F-Box Protein Fbx20 3
  • LIM Domain Only 7 2
  • KIAA0858 4

External Ids for LMO7 Gene

Previous HGNC Symbols for LMO7 Gene

  • FBXO20

Previous GeneCards Identifiers for LMO7 Gene

  • GC13P074161
  • GC13P070189
  • GC13P075131
  • GC13P073992
  • GC13P075092
  • GC13P076194
  • GC13P056891

Summaries for LMO7 Gene

Entrez Gene Summary for LMO7 Gene

  • This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]

GeneCards Summary for LMO7 Gene

LMO7 (LIM Domain 7) is a Protein Coding gene. Diseases associated with LMO7 include emery-dreifuss muscular dystrophy. Among its related pathways are PAK Pathway and Adherens junction. GO annotations related to this gene include ubiquitin-protein transferase activity and actinin binding. An important paralog of this gene is LIMCH1.

Gene Wiki entry for LMO7 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMO7 Gene

Genomics for LMO7 Gene

Regulatory Elements for LMO7 Gene

Genomic Location for LMO7 Gene

Chromosome:
13
Start:
75,620,434 bp from pter
End:
75,859,870 bp from pter
Size:
239,437 bases
Orientation:
Plus strand

Genomic View for LMO7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LMO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMO7 Gene

Proteins for LMO7 Gene

  • Protein details for LMO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWI1-LMO7_HUMAN
    Recommended name:
    LIM domain only protein 7
    Protein Accession:
    Q8WWI1
    Secondary Accessions:
    • E9PLH4
    • O15462
    • O95346
    • Q5TBK6
    • Q9UKC1
    • Q9UQM5
    • Q9Y6A7

    Protein attributes for LMO7 Gene

    Size:
    1683 amino acids
    Molecular mass:
    192696 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC96299.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC96300.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAD33924.1; Type=Frameshift; Positions=855; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LMO7 Gene

    Alternative splice isoforms for LMO7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LMO7 Gene

Proteomics data for LMO7 Gene at MOPED

Post-translational modifications for LMO7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMO7 Gene

Domains & Families for LMO7 Gene

Suggested Antigen Peptide Sequences for LMO7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWI1

UniProtKB/Swiss-Prot:

LMO7_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with LMO7: view

No data available for Gene Families for LMO7 Gene

Function for LMO7 Gene

Molecular function for LMO7 Gene

GENATLAS Biochemistry:
LIM-only protein 7,expressed in nuclear and cytosolic cell fractions

Gene Ontology (GO) - Molecular Function for LMO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with LMO7: view
genes like me logo Genes that share phenotypes with LMO7: view

Animal Models for LMO7 Gene

MGI Knock Outs for LMO7:

Animal Model Products

miRNA for LMO7 Gene

miRTarBase miRNAs that target LMO7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMO7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for LMO7 Gene

Localization for LMO7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LMO7 Gene COMPARTMENTS Subcellular localization image for LMO7 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for LMO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus TAS 9826547
GO:0005737 cytoplasm TAS 9826547
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with LMO7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LMO7 Gene

Pathways & Interactions for LMO7 Gene

genes like me logo Genes that share pathways with LMO7: view

Pathways by source for LMO7 Gene

1 Qiagen pathway for LMO7 Gene
1 KEGG pathway for LMO7 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for LMO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination NAS 10531035
GO:0023051 regulation of signaling IEA --
GO:0030155 regulation of cell adhesion IEA --
genes like me logo Genes that share ontologies with LMO7: view

No data available for SIGNOR curated interactions for LMO7 Gene

Drugs & Compounds for LMO7 Gene

(1) Drugs for LMO7 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
genes like me logo Genes that share compounds with LMO7: view

Transcripts for LMO7 Gene

Unigene Clusters for LMO7 Gene

LIM domain 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LMO7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMO7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a ·
SP1: -
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:

ExUns: 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for LMO7 Gene

GeneLoc Exon Structure for
LMO7
ECgene alternative splicing isoforms for
LMO7

Expression for LMO7 Gene

mRNA expression in normal human tissues for LMO7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LMO7 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.0) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for LMO7 Gene

This gene is overexpressed in Cervix (18.5), Bone marrow mesenchymal stem cell (16.5), Nasal epithelium (12.1), and Bone marrow stromal cell (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LMO7 Gene



SOURCE GeneReport for Unigene cluster for LMO7 Gene Hs.207631

mRNA Expression by UniProt/SwissProt for LMO7 Gene

Q8WWI1-LMO7_HUMAN
Tissue specificity: Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain.
genes like me logo Genes that share expression patterns with LMO7: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for LMO7 Gene

Orthologs for LMO7 Gene

This gene was present in the common ancestor of animals.

Orthologs for LMO7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMO7 35
  • 84.82 (n)
  • 81.5 (a)
LMO7 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LMO7 35
  • 84.73 (n)
  • 80.89 (a)
LMO7 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lmo7 35
  • 81.49 (n)
  • 79.37 (a)
Lmo7 16
Lmo7 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LMO7 35
  • 99.62 (n)
  • 99.62 (a)
LMO7 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lmo7 35
  • 79.55 (n)
  • 76.89 (a)
oppossum
(Monodelphis domestica)
Mammalia LMO7 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LMO7 36
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves LMO7 35
  • 63.99 (n)
  • 54.13 (a)
LMO7 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LMO7 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lmo7 35
  • 54.63 (n)
  • 43.47 (a)
Str.2601 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1558 35
zebrafish
(Danio rerio)
Actinopterygii lmo7a 35
  • 51.37 (n)
  • 44.4 (a)
wufc03h03 35
lmo7a 36
  • 26 (a)
OneToMany
lmo7b 36
  • 20 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43427 36
  • 3 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lim-8 36
  • 10 (a)
OneToMany
Species with no ortholog for LMO7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LMO7 Gene

ENSEMBL:
Gene Tree for LMO7 (if available)
TreeFam:
Gene Tree for LMO7 (if available)

Paralogs for LMO7 Gene

Paralogs for LMO7 Gene

genes like me logo Genes that share paralogs with LMO7: view

Variants for LMO7 Gene

Sequence variations from dbSNP and Humsavar for LMO7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_036189 A colorectal cancer sample
VAR_036190 A colorectal cancer sample
VAR_056163 -

Structural Variations from Database of Genomic Variants (DGV) for LMO7 Gene

Variant ID Type Subtype PubMed ID
nsv521444 CNV Gain 19592680
dgv1695n71 CNV Loss 21882294
esv2751152 CNV Loss 17911159
nsv819632 CNV Loss 19587683
esv2747675 CNV Deletion 23290073
esv22314 CNV Loss 19812545
nsv900579 CNV Loss 21882294
esv2083461 CNV Deletion 18987734
esv2747676 CNV Deletion 23290073
esv272630 CNV Insertion 20981092
esv269215 CNV Insertion 20981092
nsv1091 CNV Loss 18451855
nsv832646 CNV Gain 17160897
dgv574e1 CNV Complex 17122850
esv2660640 CNV Deletion 23128226
esv2666134 CNV Deletion 23128226
nsv832649 CNV Loss 17160897

Variation tolerance for LMO7 Gene

Residual Variation Intolerance Score: 78.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.01; 95.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMO7 Gene

HapMap Linkage Disequilibrium report
LMO7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMO7 Gene

Disorders for LMO7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LMO7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
emery-dreifuss muscular dystrophy
  • edmd
- elite association
Search LMO7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LMO7

Genetic Association Database (GAD)
LMO7
Human Genome Epidemiology (HuGE) Navigator
LMO7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LMO7
genes like me logo Genes that share disorders with LMO7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LMO7 Gene

Publications for LMO7 Gene

  1. Alternative splicing for members of human mosaic domain superfamilies. I. The CH and LIM domains containing group of proteins. (PMID: 18553215) Friedberg F. (Mol. Biol. Rep. 2009) 23 67
  2. Protease activity, secretion, cell entry, cytotoxicity, and cellular targets of secreted autotransporter toxin of uropathogenic Escherichia coli. (PMID: 16954394) Maroncle N.M. … Mobley H.L. (Infect. Immun. 2006) 23 67
  3. DNA-binding properties of poly(ADP-ribose) polymerase: a target for anticancer therapy. (PMID: 15134218) Soldatenkov V.A. … Potaman V.N. (Curr Drug Targets 2004) 23 67
  4. Direct association of tristetraprolin with the nucleoporin CAN/Nup214. (PMID: 14766228) Carman J.A. … Nadler S.G. (Biochem. Biophys. Res. Commun. 2004) 23 67
  5. The p75NTR-interacting protein SC1 inhibits cell cycle progression by transcriptional repression of cyclin E. (PMID: 15051733) Chittka A. … Sendtner M. (J. Cell Biol. 2004) 23 67

Products for LMO7 Gene

Sources for LMO7 Gene

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