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Aliases for LMO7 Gene

Aliases for LMO7 Gene

  • LIM Domain 7 2 3 5
  • F-Box Only Protein 20 2 3 4
  • FBXO20 3 4
  • FBX20 3 4
  • LMO-7 3 4
  • LOMP 3 4
  • Zinc-Finger Domain-Containing Protein 3
  • LIM Domain Only 7 Protein 3
  • LIM Domain Only Protein 7 3
  • F-Box Protein Fbx20 3
  • LIM Domain Only 7 2
  • KIAA0858 4

External Ids for LMO7 Gene

Previous HGNC Symbols for LMO7 Gene

  • FBXO20

Previous GeneCards Identifiers for LMO7 Gene

  • GC13P074161
  • GC13P070189
  • GC13P075131
  • GC13P073992
  • GC13P075092
  • GC13P076194
  • GC13P056891

Summaries for LMO7 Gene

Entrez Gene Summary for LMO7 Gene

  • This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]

GeneCards Summary for LMO7 Gene

LMO7 (LIM Domain 7) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and actinin binding. An important paralog of this gene is LIMCH1.

Gene Wiki entry for LMO7 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LMO7 Gene

Genomics for LMO7 Gene

Regulatory Elements for LMO7 Gene

Enhancers for LMO7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F075758 1.3 FANTOM5 Ensembl ENCODE 8.2 +141.4 141413 5.9 PKNOX1 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 CBX5 DEK SP5 LMO7DN LMO7 LMO7-AS1 COMMD6 GC13M075699 GC13M075860
GH13F075724 0.6 ENCODE 5.4 +104.8 104795 2.1 TBP PKNOX1 JUN CEBPB ZNF384 EP300 BRCA1 HIC1 JUND CTBP1 LMO7 GC13M075699 GC13M075860
GH13F075715 1 FANTOM5 Ensembl ENCODE 4.6 +96.2 96192 2.8 TBP KLF17 FEZF1 RAD21 BRCA1 RFX5 GTF3C2 POLR3A FOS CREM LMO7DN LMO7 GC13M075699 GC13M075860
GH13F076020 0.2 ENCODE 4.4 +399.2 399186 0.2 CTCF ZNF654 ZNF143 ZBTB33 RAD21 ZBTB20 TRIM28 LMO7DN LMO7 LINC01034 RN7SL571P
GH13F075703 0.8 FANTOM5 Ensembl ENCODE 1.6 +84.8 84750 3.6 TBP PKNOX1 KLF17 FEZF1 BRCA1 RAD21 FOS ZNF362 CEBPB TSHZ1 LMO7 GC13M075699 FAM204CP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LMO7 on UCSC Golden Path with GeneCards custom track

Genomic Location for LMO7 Gene

75,620,434 bp from pter
75,859,870 bp from pter
239,437 bases
Plus strand

Genomic View for LMO7 Gene

Genes around LMO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LMO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LMO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LMO7 Gene

Proteins for LMO7 Gene

  • Protein details for LMO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LIM domain only protein 7
    Protein Accession:
    Secondary Accessions:
    • E9PLH4
    • O15462
    • O95346
    • Q5TBK6
    • Q9UKC1
    • Q9UQM5
    • Q9Y6A7

    Protein attributes for LMO7 Gene

    1683 amino acids
    Molecular mass:
    192696 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC96299.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC96300.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAD33924.1; Type=Frameshift; Positions=855; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LMO7 Gene

    Alternative splice isoforms for LMO7 Gene


neXtProt entry for LMO7 Gene

Post-translational modifications for LMO7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LMO7 Gene

Domains & Families for LMO7 Gene

Suggested Antigen Peptide Sequences for LMO7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 LIM zinc-binding domain.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with LMO7: view

Function for LMO7 Gene

Molecular function for LMO7 Gene

GENATLAS Biochemistry:
LIM-only protein 7,expressed in nuclear and cytosolic cell fractions

Gene Ontology (GO) - Molecular Function for LMO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0008022 protein C-terminus binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0042805 actinin binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LMO7: view
genes like me logo Genes that share phenotypes with LMO7: view

Animal Models for LMO7 Gene

MGI Knock Outs for LMO7:

Animal Model Products

miRNA for LMO7 Gene

miRTarBase miRNAs that target LMO7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LMO7 Gene

Localization for LMO7 Gene

Subcellular locations from

Jensen Localization Image for LMO7 Gene COMPARTMENTS Subcellular localization image for LMO7 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for LMO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005634 nucleus TAS 9826547
GO:0005737 cytoplasm TAS 9826547
GO:0005913 cell-cell adherens junction IEA --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with LMO7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LMO7 Gene

Pathways & Interactions for LMO7 Gene

genes like me logo Genes that share pathways with LMO7: view

Pathways by source for LMO7 Gene

Gene Ontology (GO) - Biological Process for LMO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0016567 protein ubiquitination NAS 10531035
GO:0023051 regulation of signaling IEA --
GO:0030155 regulation of cell adhesion IEA --
genes like me logo Genes that share ontologies with LMO7: view

No data available for SIGNOR curated interactions for LMO7 Gene

Drugs & Compounds for LMO7 Gene

(1) Drugs for LMO7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with LMO7: view

Transcripts for LMO7 Gene

Unigene Clusters for LMO7 Gene

LIM domain 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LMO7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a ·
SP1: -
SP3: -
SP4: -
SP7: -

ExUns: 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b ^ 31
SP1: - -

Relevant External Links for LMO7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LMO7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LMO7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LMO7 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.0) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for LMO7 Gene

This gene is overexpressed in Cervix (18.5), Bone marrow mesenchymal stem cell (16.5), Nasal epithelium (12.1), and Bone marrow stromal cell (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LMO7 Gene

NURSA nuclear receptor signaling pathways regulating expression of LMO7 Gene:


SOURCE GeneReport for Unigene cluster for LMO7 Gene:


mRNA Expression by UniProt/SwissProt for LMO7 Gene:

Tissue specificity: Widely expressed. Isoform 2 and isoform 4 are predominantly expressed in brain.
genes like me logo Genes that share expression patterns with LMO7: view

Primer Products

No data available for Protein tissue co-expression partners for LMO7 Gene

Orthologs for LMO7 Gene

This gene was present in the common ancestor of animals.

Orthologs for LMO7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LMO7 34 35
  • 99.62 (n)
(Bos Taurus)
Mammalia LMO7 34 35
  • 84.82 (n)
(Canis familiaris)
Mammalia LMO7 34 35
  • 84.73 (n)
(Mus musculus)
Mammalia Lmo7 34 16 35
  • 81.49 (n)
(Rattus norvegicus)
Mammalia Lmo7 34
  • 79.55 (n)
(Monodelphis domestica)
Mammalia LMO7 35
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia LMO7 35
  • 35 (a)
(Gallus gallus)
Aves LMO7 34 35
  • 63.99 (n)
(Anolis carolinensis)
Reptilia LMO7 35
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lmo7 34
  • 54.63 (n)
Str.2601 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1558 34
(Danio rerio)
Actinopterygii lmo7a 34 35
  • 51.37 (n)
lmo7b 35
  • 20 (a)
wufc03h03 34
fruit fly
(Drosophila melanogaster)
Insecta CG43427 35
  • 3 (a)
(Caenorhabditis elegans)
Secernentea lim-8 35
  • 10 (a)
Species where no ortholog for LMO7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LMO7 Gene

Gene Tree for LMO7 (if available)
Gene Tree for LMO7 (if available)

Paralogs for LMO7 Gene

Variants for LMO7 Gene

Sequence variations from dbSNP and Humsavar for LMO7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_036189 A colorectal cancer sample
VAR_036190 A colorectal cancer sample
rs1001034 -- 75,633,429(-) CCGTA(C/T)TGGGG intron-variant
rs1006408 -- 75,642,414(+) AGCCT(A/G)GTCAA intron-variant
rs1006412 -- 75,643,940(-) ACAGA(A/G)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LMO7 Gene

Variant ID Type Subtype PubMed ID
dgv3257n54 CNV gain 21841781
dgv3258n54 CNV loss 21841781
dgv3259n54 CNV loss 21841781
dgv3260n54 CNV loss 21841781
esv2083461 CNV deletion 18987734
esv22314 CNV loss 19812545
esv2660640 CNV deletion 23128226
esv2666134 CNV deletion 23128226
esv2747675 CNV deletion 23290073
esv2747676 CNV deletion 23290073
esv2751152 CNV loss 17911159
esv2759950 CNV loss 17122850
esv3304937 CNV mobile element insertion 20981092
esv3308356 CNV mobile element insertion 20981092
esv3335407 CNV insertion 20981092
esv3408857 CNV insertion 20981092
esv3428325 CNV insertion 20981092
esv3632750 CNV loss 21293372
esv3632754 CNV loss 21293372
esv3632755 CNV loss 21293372
nsv1070182 CNV deletion 25765185
nsv1091 CNV deletion 18451855
nsv1127344 CNV deletion 24896259
nsv472396 CNV novel sequence insertion 20440878
nsv521444 CNV gain 19592680
nsv562348 CNV gain+loss 21841781
nsv562359 CNV gain 21841781
nsv819632 CNV loss 19587683
nsv832646 CNV gain 17160897
nsv832649 CNV loss 17160897
nsv976261 CNV duplication 23825009

Variation tolerance for LMO7 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.01; 95.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LMO7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LMO7 Gene

Disorders for LMO7 Gene

Relevant External Links for LMO7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LMO7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LMO7 Gene

Publications for LMO7 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C. … Pagano M. (Curr. Biol. 1999) 2 3 4 64
  2. Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain. (PMID: 9826547) Putilina T. … Wong P. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  3. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield J.P. … Hakonarson H. (PLoS Genet. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for LMO7 Gene

Sources for LMO7 Gene

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